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Littérature scientifique sur le sujet « AMCase »

Auteur : Grafiati

Publié le 14 mars 2023

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Articles de revues sur le sujet "AMCase"

Ramanathan, Murugappan, Won-Kyung Lee et Andrew P. Lane. « Increased Expression of Acidic Mammalian Chitinase in Chronic Rhinosinusitis with Nasal Polyps ». American Journal of Rhinology 20, n^o 3 (mai 2006) : 330–35. http://dx.doi.org/10.2500/ajr.2006.20.2869.

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Background Chitin is an abundant polysaccharide found in fungi, insects, and parasitic nematodes. Innate immune host defense against chitin-containing pathogens include production of chitinases. In human lower airways, acidic mammalian chitinase (AMCase) is produced in epithelial cells via a Th2-specific, IL-13–dependent pathway, and may act as an inflammatory mediator in asthma. The role of AMCase in chronic rhinosinusitis (CRS) has not been studied previously. Methods Eleven controls and 22 subjects with medically recalcitrant CRS were prospectively enrolled before undergoing endoscopic sinus surgery. RNA was extracted from surgically obtained ethmoid mucosa, and real-time PCR was used to determine expression of AMCase, eotaxin, and IL-13. Subjects were followed for at least 6 months postoperatively to assess for polyp recurrence. Based on the presence or absence of polyps, the subjects were classified as either recalcitrant or responsive to therapy. Results AMCase mRNA was detected in the sinus mucosa of 72% of control subjects and in 72% of patients with eosinophilic CRS with nasal polyps (CRSwNP). The expression of AMCase was significantly greater in recalcitrant CRSwNP than it was in treatment-responsive CRSwNP. There was no significant difference in IL-13 expression between these two groups. Conclusion AMCase may be an important mediator in the pathogenesis of Th2 inflammatory diseases of the respiratory tract. Failure of medical and surgical therapy in CRSwNP is associated with significantly increased expression of AMCase, but not the Th2 cytokines IL-13 and eotaxin. Additional studies are needed to determine the potential of AMCase as a therapeutic target in CRSwNP.

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Yang, Ming, Yunjo Soh et Seok-Mo Heo. « Characterization of Acidic Mammalian Chitinase as a Novel Biomarker for Severe Periodontitis (Stage III/IV) : A Pilot Study ». International Journal of Environmental Research and Public Health 19, n^o 7 (30 mars 2022) : 4113. http://dx.doi.org/10.3390/ijerph19074113.

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Periodontitis is a chronic inflammatory condition characterized by gingival infection, periodontal pocket formation, and alveolar bone loss. Acidic mammalian chitinase (AMCase), an active chitinase enzyme, increased its expression under severe inflammation and related systemic disorders. However, AMCase expression and molecular mechanism in periodontal inflammation, have not been elucidated yet. This study was aimed to characterize AMCase in severe periodontitis patients compare to those in periodontally healthy subjects. In total, 15 periodontally healthy subjects and 15 severe (stage III/IV) periodontitis patients were enrolled with their informed consent. Tissue samples were collected and analyzed using Western blot and enzyme-linked immunosorbent assay (ELISA). AMCase protein expressions in periodontal patients were significantly more increased than those of periodontally healthy individuals. ELISA resulted in median values (first quartile to third quartile) of the periodontally healthy group 0.654 ng/mL (range, 0.644–0.827 ng/mL) and the periodontitis group 0.965 ng/mL (range, 0.886–1.165 ng/mL). AMCase was expressed significantly higher levels in periodontitis patients than in periodontally healthy individuals (p < 0.05). This suggests that AMCase may play a potential role as a biomarker for the screening and early diagnosis of severe periodontitis.

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Mackel, Joseph J., Jaleesa M. Garth, Kristen M. Reeder, Jonathan Blackburn et Chad Steele. « The contribution of acidic mammalian chitinase to disease severity in experimental fungal asthma ». Journal of Immunology 198, n^o 1_Supplement (1 mai 2017) : 135.3. http://dx.doi.org/10.4049/jimmunol.198.supp.135.3.

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Abstract Chitin is a polysaccharide that provides structure and rigidity to the fungal cell wall. Exposure to A. fumigatus cell wall moieties such as chitin has been linked to fungal sensitization and allergic inflammation. Chitin is not present in mammals, however, mammals possess enzymes that function to degrade chitin known as chitinases. Mammals possess two functional chitinases, acidic mammalian chitinase (AMCase) and chitotriosidase. Although chitinase expression has been linked to Th2 respiratory disorders, their exact role in fungal sensitization and fungal asthma has not been determined. In an allergic asthma model associated with chronic A. fumigatus exposure, mice deficient in AMCase displayed attenuated levels of the proallergic/pro-type 2 factors CCL22, CCL17, and IL-33. Furthermore, a deficiency in AMCase led to improved total lung function. Surprisingly, examination of inflammatory responses revealed attenuated IL-17 and IL-22 responses, but not type 2 responses (IL-4, IL-5, IL-13), in the absence of AMCase. Collectively, these data suggest that expression of AMCase during allergic fungal asthma is associated with increased severity that is putatively associated with IL-17A and IL-22 responses.

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Homer, Robert J., Zhou Zhu, Lauren Cohn, Chun Gun Lee, Wendy I. White, Suping Chen et Jack A. Elias. « Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation ». American Journal of Physiology-Lung Cellular and Molecular Physiology 291, n^o 3 (septembre 2006) : L502—L511. http://dx.doi.org/10.1152/ajplung.00364.2005.

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The mammalian chitinase family includes members both with and without enzymatic activity against chitin, a product of fungal cell walls, exoskeletons of crustaceans and insects, and the microfilarial sheaths of parasitic nematodes. Two members of that family, Ym1 and acidic mammalian chitinase (AMCase), are strongly upregulated in pulmonary T helper (Th) 2 inflammation but not in Th1 inflammation. The sites of expression of these products are incompletely known. We show here that, in two different models of Th2 inflammation, Ym1 and AMCase are mutually exclusively expressed in proximal vs. distal airway epithelium, respectively, whereas both are expressed in alveolar macrophages. This regional difference along the airway corresponds to the previously noted distinction between mucus positive proximal cells and mucus negative distal cells under the same conditions. Among distal cells, AMCase colocalizes with epithelial cells expressing the Clara cell marker Clara cell secretory protein. These AMCase-expressing cells retain expression of FOXA2, a transcription factor whose downregulation in association with IL-13 signaling has previously been associated with production of mucus in proximal airway epithelial cells. These results provide evidence that secretory cells of proximal and distal airways undergo fundamentally different gene expression programs in response to allergic inflammation. Furthermore, AMCase provides the first positive molecular marker of distal Clara cell secretory protein-expressing cells under these conditions.

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Worth, Danielle, John Philip Nance, Jessica Jang, Clement David, Meera Nair et Emma Wilson. « A role for dectin-1 in the CNS during chronic Toxoplasma gondii infection (MPF5P.739) ». Journal of Immunology 194, n^o 1_Supplement (1 mai 2015) : 137.2. http://dx.doi.org/10.4049/jimmunol.194.supp.137.2.

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Abstract The latent stage of T.gondii infection is characterized by the formation of tissue cysts within the CNS. These tissue cysts are formed by manipulation of the parasitophorous vacuole, and chitin is a structural component of the cyst wall. Our lab has shown that Toxoplasma cysts induce an M2 phenotype in macrophages in a contact-dependent manner. Upon contact, these macrophages actively secrete the mammalian chitinase, AMCase, to break down the cyst wall. We have previously demonstrated that AMCase production by macrophages is essential for control of cyst burden in the brain during T. gondii infection. The molecular interactions involved in macrophage-cyst recognition, and the signaling pathway for AMCase production are as yet unknown. Although chitin recognition has been poorly defined, studies suggest dectin-1 may be a receptor. Here, we present data on a role for dectin-1 during T. gondii infection. Dectin-1 is upregulated in the brain in response to infection and is expressed on arginase-1+, M2 macrophages. Consistent with dectin-1 expression on M2 macrophages, dectin-1 is not required to control parasite burden or induce an inflammatory immune response in vivo. However, dectin-1 deficient mice do exhibit trends towards decreased cyst numbers in the brain and a concomitant increase in AMCase transcripts and AMCase activity ex vivo. Thus, this data suggests that dectin-1 is modulating the immune response and chitinase production during chronic Toxoplasma infection.

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Boot, Rolf G., Anton P. Bussink, Marri Verhoek, Piet A. J. de Boer, Antoon F. M. Moorman et Johannes M. F. G. Aerts. « Marked Differences in Tissue-specific Expression of Chitinases in Mouse and Man ». Journal of Histochemistry & ; Cytochemistry 53, n^o 10 (27 juin 2005) : 1283–92. http://dx.doi.org/10.1369/jhc.4a6547.2005.

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Two distinct chitinases have been identified in mammals: a phagocyte-specific enzyme named chitotriosidase and an acidic mammalian chitinase (AMCase) expressed in the lungs and gastrointestinal tract. Increased expression of both chitinases has been observed in different pathological conditions: chitotriosidase in lysosomal lipid storage disorders like Gaucher disease and AMCase in asthmatic lung disease. Recently, it was reported that AMCase activity is involved in the pathogenesis of asthma in an induced mouse model. Inhibition of chitinase activity was found to alleviate the inflammation-driven pathology. We studied the tissue-specific expression of both chitinases in mice and compared it to the situation in man. In both species AMCase is expressed in alveolar macrophages and in the gastrointestinal tract. In mice, chitotriosidase is expressed only in the gastrointestinal tract, the tongue, fore-stomach, and Paneth cells in the small intestine, whereas in man the enzyme is expressed exclusively by professional phagocytes. This species difference seems to be mediated by distinct promoter usage. In conclusion, the pattern of expression of chitinases in the lung differs between mouse and man. The implications for the development of anti-asthma drugs with chitinases as targets are discussed.

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Kim, Lark Kyun, Rimpei Morita, Yasushi Kobayashi, Stephanie C. Eisenbarth, Chun Geun Lee, Jack Elias, Elizabeth E. Eynon et Richard A. Flavell. « AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites ». Proceedings of the National Academy of Sciences 112, n^o 22 (18 mai 2015) : E2891—E2899. http://dx.doi.org/10.1073/pnas.1507393112.

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Chitinases are enzymes that cleave chitin, a component of the exoskeleton of many organisms including the house dust mite (HDM). Here we show that knockin mice expressing an enzymatically inactive acidic mammalian chitinase (AMCase), the dominant true chitinase in mouse lung, showed enhanced type 2 immune responses to inhaled HDM. We found that uncleaved chitin promoted the release of IL-33, whereas cleaved chitin could be phagocytosed and could induce the activation of caspase-1 and subsequent activation of caspase-7; this results in the resolution of type 2 immune responses, probably by promoting the inactivation of IL-33. These data suggest that AMCase is a crucial regulator of type 2 immune responses to inhaled chitin-containing aeroallergens.

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Mazur, Marzena, Jakub Włodarczyk, Mikołaj Świerczyński, Radzisław Kordek, Marcin M. Grzybowski, Jacek Olczak et Jakub Fichna. « The Anti-Inflammatory Effect of Acidic Mammalian Chitinase Inhibitor OAT-177 in DSS-Induced Mouse Model of Colitis ». International Journal of Molecular Sciences 23, n^o 4 (15 février 2022) : 2159. http://dx.doi.org/10.3390/ijms23042159.

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Inflammatory bowel diseases (IBD) are chronic and relapsing gastrointestinal disorders, where a significant proportion of patients are unresponsive or lose response to traditional and currently used therapies. In the current study, we propose a new concept for anti-inflammatory treatment based on a selective acidic mammalian chitinase (AMCase) inhibitor. The functions of chitinases remain unclear, but they have been shown to be implicated in the pathology of various inflammatory disorders regarding the lung (asthma, idiopathic pulmonary fibrosis) and gastrointestinal tract (IBD and colon cancer). The aim of the study is to investigate the impact of AMCase inhibitor (OAT-177) on the dextran sulfate sodium (DSS)-induced models of colitis. In the short-term therapeutic protocol, OAT-177 given intragastrically in a 30 mg/kg dose, twice daily, produced a significant (p < 0.001) anti-inflammatory effect, as shown by the macroscopic score. Additionally, OAT-177 significantly decreased TNF-α mRNA levels and MPO activity compared to DSS-only treated mice. Intraperitoneal administration of OAT-177 at a dose of 50 mg/kg caused statistically relevant reduction of the colon length. In the long-term therapeutic protocol, OAT-177 given intragastrically in a dose of 30 mg/kg, twice daily, significantly improved colon length and body weight compared to DSS-induced colitis. This is the first study proving that AMCase inhibitors may have therapeutic potential in the treatment of IBD.

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Kzhyshkowska, Julia, Alexei Gratchev et Sergij Goerdt. « Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer ». Biomarker Insights 2 (janvier 2007) : 117727190700200. http://dx.doi.org/10.1177/117727190700200023.

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Human Glyco_18 domain-containing proteins constitute a family of chitinases and chitinase-like proteins. Chitotriosidase and AMCase are true enzymes which hydrolyse chitin and have a C-terminal chitin-binding domain. YKL-40, YKL-39, SI-CLP and murine YM1/2 proteins possess solely Glyco_18 domain and do not have the hydrolytic activity. The major sources of Glyco_18 containing proteins are macrophages, neutrophils, epithelial cells, chondrocytes, synovial cells, and cancer cells. Both macrophages and neutrophils use the regulated secretory mechanism for the release of Glyco_18 containing proteins. Glyco_18 containing proteins are established biomarkers for human diseases. Chitotriosidase is overproduced by lipid-laden macrophages and is a major marker for the inherited lysosomal storage Gaucher disease. AMCase and murine lectin YM1 are upregulated in Th2-environment, and enzymatic activity of AMCase contributes to asthma pathogenesis. YKL proteins act as soluble mediators for the cell proliferation and migration, and are also involved in rheumatoid arthritis, inflammatory bowel disease, hepatic fibrosis and cirrhosis. Chitotriosidase and YKL-40 reflect the macrophage activation in atherosclerotic plaques. Serum level of YKL-40 is a diagnostic and prognostic marker for numerous types of solid tumors. YKL-39 is a marker for the activation of chondrocytes and the progression of the osteoarthritis in human. Recently identified SI-CLP is upregulated by Th2 cytokine IL-4 as well as by glucocorticoids. This unique feature of SI-CLP makes it an attractive candidate for the examination of individual sensitivity of patients to glucocorticoid treatment and prediction of side effects of glucocorticoid therapy. Human chitinases and chitinase-like proteins are found in tissues and circulation, and can be detected by non-invasive technologies.

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Musumeci, M., C. Bucolo, F. Drago et S. Musumeci. « Acidic mammalian chitinase (AMCase) : A new target for ocular diseases ». Drugs of the Future 36, n^o 2 (2011) : 141. http://dx.doi.org/10.1358/dof.2011.036.02.1534822.

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Thèses sur le sujet "AMCase"

Fiorucci. « On the Chitinase target evolution, from fungi to humans ». Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1048358.

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Chitinase proteins are expressed in most of reigns, from fungi to mammals. This kind of proteins can cleave the chitin, the second most abundant polysaccharide in nature. Mammals do not synthesize nor are able to use it, but they express Chitinase proteins. It has been proved that this kind of proteins are involved in several pathologies. Human Acidic Mammalian Chitinase is involved in the development of pathologies related to the Th2 inflammation. It has been discovered that the inhibition of this protein allowed the reduction of the inflammation. This effect makes this protein a very interesting target for the treatment of this kind of pathologies. In this PhD thesis, the first subject is the target fishing procedure applied to a series of macrocyclic compounds endowed with antifungal activity. The result of the target fishing has been the chitinase protein, and it has been rationally designed a new derivative able to inhibit the chitinase protein with higher potency. The second theme of this work has been the computational study the complex between the rationally designed chitinase inhibitor and the human Acidic Mammalian Chitinase, to identify the most reliable binding mode of the compound inside the binding pocket. The identification of the binding mode has been followed by the design of a library of derivatives, using the information acquired after the study, to improve the activity of the series of compounds towards the Acidic Mammalian Chitinase. The last topic has been the Structure Based Virtual Screening on the Acidic Mammalian Chitinase to find novel scaffolds active as AMCase inhibitor. A first screening based on pharmacophoric filtration and docking calculations has been done, identifying a preliminary hit, on which it has been performed a substructure search, that allowed the discovery of a more active derivative. This molecule has been examined with Molecular Dynamics simulations observing modification in the binding mode during each replica. It has been done a cluster analysis used for the generation of a new pharmacophoric model. The selected cluster representatives have been used as receptors for an ensemble docking calculation that allowed the identification of a third molecule biologically active as AMCase inhibitor.

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G, Truglio. « Synthesis and biological evaluation of hAMCase inhibitors and anomeric equilibrium of gluco and xylopyranose derivatives in D2O ». Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1070882.

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Asthma is considered a serious health and socioeconomic issue all over the world, affecting more than 300 million individuals. It is a chronic inflammatory disease characterized by airway inflammation, mucus hypersecretion and airway hyperresponsiveness. One of the causes of this disorder is the result of an abnormal Th2-dependent response to environmental antigens. In particular, Th2 cells produce cytokines, such as interleukin (IL)-4, IL-5, IL-9, and especially IL-13, in the airway wall, associated with the asthma symptoms. Acidic Mammalian Chitinase (AMCase) is a chitinolytic enzyme belonging to glycosyl hydrolases family. AMCase seems to be involved in Th2 inflammatory diseases, such as asthma. It has been demonstrated that during Th2-dependent inflammation IL-13 induces the AMCase expression in the airways epithelial cells and alveolar macrophages, which stimulates the release of chemokines, recruiters of proinflammatory agents. In conclusion, AMCase contributes to the pathogenesis of asthma and represents a potential therapeutic target for the treatment of this disease and other forms of Th2-mediated inflammation. Prof. Botta research group, after a careful study, designed and synthesized an innovative AMCase inhibitor, BM22 (Ki = 13.2 μM), characterized by a macrocyclic structure. The aim of this work was the study of BM22 chemical space in order to improve its activity with the exploration of the macrocyclic portion, the linker length and substitution the amidinourea terminal moiety with a diamino-triazole group. Some of these compounds have been tested against AMCase enzyme and showed a better activity compared to that of BM22. The last chapter of this thesis deals with the study of the anomeric equilibrium of xylo and glucopyranoses in D2O at room temperature. The anomeric effect is an effect that determines the increased preference of the axial position of the C1 substituent in a pyranose ring, rather than the sterically preferred equatorial position. Two models were proposed to explain this effect: Electrostatic model and Hyperconjugation model. The anomeric ratio was established by qNMR, which involved integration of resolved signals in 1H-NMR spectrum. Interesting results have been obtained, as all compounds showed a preference for α-anomer, including, surprisingly, the electron donating methoxy group as well.

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Balestri, Lorenzo Jacopo Ilic. « SYNTHESIS OF ANTIFUNGAL COMPOUNDS ». Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1203145.

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Systemic fungal infections represent a threat to public health, and annually more than 150 million people suffer from fungal diseases. This worrisome data reflects the growing group of patients with immunocompromised conditions: due to cancer chemotherapy, organ transplanting or affected by AIDS, and the outbreaks of azoles resistant strains. Moreover, the global emergency caused by SARS-CoV-2 led to long term hospitalizations, and intubation increased the susceptibility to developing fungal infections. Therefore, now more than ever, the challenge of developing new antifungal drugs is dramatically urgent. Our research group has been interested in the great potential of guanylated compounds as new antifungal agents since 2007. During these 15 years, three series of derivatives, characterized by an amidinoureas scaffold, have been developed. The structure of these compounds is new and not shared with other antifungal drugs present on the market. Consequently, they show remarkably antifungal activity, especially among Candida strains resistant to azole drugs. The first chapter of my thesis deals with synthesizing new antifungal compounds with a macrocyclic amidinourea scaffold. Firstly, a novel compound, BM37, was synthesized through a convergent approach using the ring-closing metathesis (RCM)as a key step. Secondly, we decided to conduct advanced biological investigations of our lead compound, BM1. Consequently, we face the need to prepare this compound on a gram scale. To achieve this result, we changed the synthetic route and took inspiration from Fukuyama’s work designing a new strategy to obtain 1 gram of BM1. The second chapter of my thesis explores the design and synthesis of novel inhibitors targeting human chitinases. This project started when we investigated a putative target for the amidinoureas compounds endowed with antifungal activity. This research led us to the Chitinase family. In particular, our interest fell on human chitinases due to their involvement in chronic inflammatory lung diseases. The development of new human chitinase inhibitors, characterized by two different chemical scaffolds, is the aim of this second chapter. The former was the macrocyclic amidinoureas scaffold. Here three derivatives: BM56, BM57 and BM58, were synthesized and evaluated on human chitinases. The latter explored the chemical space related to the 6-piperazine-1-ylpyrazine-2-carboxamide, a new scaffold that emerged from a structure-based virtual screening. In this case, we synthesized a small, focused library of derivatives. The third chapter of my thesis describes my work as visiting PhD student at Uppsala University. During this period, I have been involved in the alkylation of the N position of 3-methyl indole with several cyclic ketones using a green and efficient amide coupling reagent, the TP3®. Finally, the last chapter contains chemical and biological data of all the compounds presented in the thesis.

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Korenstein, Alyssa. « Predictors of Primary Care Career Choice : A Review of AMCAS Applications of Four Graduating Classes at a New Medical School ». Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623466.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
The United States (U.S.) is currently facing a shortage of primary care physicians, an issue particularly salient in Arizona. The purpose of this project is to investigate predictors of students entering primary care specialties that may be apparent from their American Medical College Application Service (AMCAS) applications, in order to best serve the needs of the physician workforce. We hypothesized that factors such as female gender, older age at application (“non‐traditional” students), and being raised in a rural/underserved community background may be predictors of students who choose primary care fields. AMCAS applications are completed by aspiring medical students and contain demographic information including gender, age, race, languages spoken, and family/community characteristics. Data provided also include academic factors such as college major, grade point average (GPA), and Medical College Admissions Test (MCAT) scores. Other subjective data reported by applicants include descriptions of extracurricular activities and a personal statement. The National Resident Matching Program (NRMP) is the system used by graduating students during the last semester of medical school to match students with their choice of specialty and the residency program wherein they will spend an additional three years, minimum, in training. Based on the Association of American Medical Colleges (AAMC) designations, we are considering primary care to be Family Medicine, Pediatrics, Internal Medicine, and Medicine‐Pediatrics. We examined data from AMCAS applications of all 149 students who graduated from the University of Arizona College of Medicine‐Phoenix between 2011‐2014, and compared to their NRMP match outcomes. Comparisons were made between non‐primary care versus primary care‐overall, as well as Family Medicine alone versus all other matches given the increasing rate of specialization within Internal Medicine and Pediatrics. Multiple logistic regression revealed two predictors of primary care career choice compared to non‐primary care: having more siblings (P=.003) and non‐physician parents (P=.017). Specific to Family Medicine, several predictors were identified compared to the non‐Family Medicine cohort: a slightly greater percentage of earned community college credits (P=.03), lower MCAT physical science (P=.009), higher MCAT verbal scores (P=.02), and lower paternal education (P=.003). Our analyses suggest having a greater number of siblings and non‐physician parents may predict primary care career choice. Specific to Family Medicine, academic factors including community college enrollment and MCAT scores may be of predictive value. Though the exact implications behind these findings are unclear, it is important to continually examine such data as medical schools can shape admissions selection criteria targeted at increasing the number of graduates seeking careers in primary care.

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Greenberg, Fernando Guajará. « Bases para a estruturação de uma Agência Municipal de Cadastro - AMCA ». Florianópolis, SC, 2003. http://repositorio.ufsc.br/xmlui/handle/123456789/84677.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.
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Este trabalho tem como objetivo revigorar as condições de gerência administrativa pública Municipal considerando o Estatuto da Cidade e as dificuldades de implantação de infra-estrutura antecipadamente à ocupação nas cidades. Muitas são as dificuldades para o bom relacionamento entre Empresas, Poder Público e população, dando incômodos e desperdícios para o usuário final. Nesta pesquisa é proposta a criação da AMCA - Agência Municipal de Cadastro, que atuaria basicamente em três frentes: 1) Base de dados gerenciados por um Sistema de Informações Geográficas (SIG), com a criação e manutenção de sistema confiável; 2) Contratos ou Termos de Permissão de Uso de utilização dos espaços públicos, subsolo e aéreos por parte das concessionárias, bem como padronização de procedimentos, e; 3) Minimizar, pela racionalização de quaisquer serviços infra-estruturais, o incômodo e os prejuízos provocados por obras descoordenadas e fora de um controle central local, interagindo com a população muito mais ativamente, não só se pronunciando quando solicitada, mas informando antecipadamente. Vantagens da proposta são implantação imediata, banco de dados confiáveis, repasse do excedente dos recursos dos contratos a outras áreas de interesse social, resgate das atribuições e responsabilidades e facilidade de localização de problemas e de rápida e barata solução, envolvendo ajustes na mentalidade e postura das pessoas envolvidas, com resultados futuros positivos, quer pela melhor racionalização de serviços de infra-estrutura, quer pela redução do volume de obras de duração incerta e de ação desordenada e incômoda.

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Alhashmy, Hasan. « Fabrication of Aluminium Matrix Composites (AMCs) by Squeeze Casting Technique Using Carbon Fiber as Reinforcement ». Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23120.

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Composites have been developed with great success by the use of fiber reinforcements in metallic materials. Fiber reinforced metal matrices possess great potential to be the next generation of advanced composites offering many advantages compared to fiber reinforced polymers. Specific advantages include high temperature capability, superior environmental stability, better transverse modulus, shear and fatigue properties. Although many Metal Matrix Composites (MMCs) are attractive for use in different industrial applications, Aluminium Matrix Composites (AMCs) are the most used in advanced applications because they combine acceptable strength, low density, durability, machinability, availability, effectiveness and cost. The present study focuses on the fabrication of aluminium matrix composite plates by squeeze casting using plain weave carbon fiber preform (AS4 Hexcel) as reinforcement and a matrix of wrought aluminium alloy 1235-H19. The objective is to investigate the process feasibility and resulting materials properties such as hardness at macro- and micro-scale, impact and bend strength. The properties obtained are compared with those of 6061/1235-H19 aluminium plates that were manufactured under the same fabrication conditions. The effect of fiber volume fraction on the properties is also investigated. Furthermore, the characterization of the microstructure is done using Optical Microscopy (OM) and Scanning Electron Microscopy (SEM) in order to establish relationships between the quality of the fiber/aluminium interface bond and mechanical properties of the composites. In conclusion, aluminium matrix composite laminate plates were successfully produced. The composites show a good chemical bond between the fiber and the aluminium matrix. This bond resulted from heterogeneous precipitation of aluminium carbides (Al4C3) at the interface between aluminium matrix and carbon fiber. The hardness at macro- and micro-scale of the composites increases by over 50% and the flexural modulus increases by about 55%. The toughness of the composite decreases due to the presence of brittle phases which can be improved by better oxidation prevention. Also, an optimal carbon volume fraction was observed that provides optimal properties including peak hardness, peak stiffness and peak toughness.

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Ashton, Samuel L. « Beliefs, Practices, and Training in Marriage Preparation : A Comparison Between Members of the Association of Mormon Counselors and Psychotherapists (AMCAP) and Select Protestant Clergy ». Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd897.pdf.

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Kwan, Cheuk Hung. « Biosensors for biological nutrient monitoring / ». View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202004%20KWAN.

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Zhang, Tao. « Regulation of EGY1 gene expression by environmental factors and developmental cues / ». View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202005%20ZHANG.

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Lee, On On. « Possible controls of epibiosis in the sponge : mycale adhaerens / ». View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202005%20LEE.

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Livres sur le sujet "AMCase"

Amcam Hamlet. Cağaloğlu, İstanbul : Everest Yayınları, 2001.

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AMC's best sea kayaking in New England. Boston, Massachusetts : Appalachian Mountain Club Books, 2016.

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Carl, Demrow, et Appalachian Mountain Club, dir. AMC's complete guide to trail building & maintenance. 4^e éd. Boston, Mass : Appalachian Mountain Club Books, 2008.

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Carl, Demrow, et Appalachian Mountain Club, dir. AMC's complete guide to trail building and maintenance. 4^e éd. Boston, MA : Appalachian Mountain Club Books, 2008.

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Passport to AMC's high huts in the White Mountains. Boston : Appalachian Mountain Club Books, 2011.

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S, Burk John, et Appalachian Mountain Club, dir. Massachusetts trail guide : AMC's comprehensive guide to hiking trails in Massachusetts. 9^e éd. Boston, MA : Appalachian Mountain Club Books, 2009.

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Club, Appalachian Mountain, dir. Massachusetts trail guide : AMC's comprehensive guide to hiking trails in Massachusetts. Boston, Massachusetts : Appalachian Mountain Club Books, 2016.

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O'Connor, Michael. Discover Cape Cod : AMC's guide to the best hiking, biking, and paddling. Boston : Appalachian Mountain Club Books, 2009.

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Kick, Peter. Catskill Mountain guide : AMC's comprehensive guide to hiking trails in the Catskills. 2^e éd. Boston, MA : Appalachian Mountain Club Books, 2009.

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Club, Appalachian Mountain, dir. Discover Martha's Vineyard : AMC's guide to the best hiking, biking, and paddling. Boston, MA : Appalachian Mountain Club Books, 2009.

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Chapitres de livres sur le sujet "AMCase"

Cuccurullo, Corrado, Luca D’Aniello, Massimo Aria et Maria Spano. « Measuring the impact of healthcare indicators on academic medical centers’ scientific production ». Dans Proceedings e report, 161–65. Florence : Firenze University Press, 2021. http://dx.doi.org/10.36253/978-88-5518-461-8.31.

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The Italian public-owned Academic Medical Centers (AMCs) are hospitals where the activities of scientific research, teaching, and patients care are fully integrated. AMCs have an enormous impact on society and country health. Recently, policymakers and practitioners give more and more great importance to the AMCs’ scientific activity for both welfare and national competitivity. The scientific production and its impact on the research community could be obviously affected by different factors related to the structural and operational characteristics of each AMC. Healthcare institutions could be different for the typology of services that they offer, their geolocation, the presence/absence of Emergency Departments, the number of employees, and so forth. In this sense, our study aims to investigate and determine which are the possible factors impacting the research productivity of AMCs. We develop a model to assess the academic value of AMCs by taking into account these factors and how they are related to healthcare performance, measured in terms of scientific production (e.g. scientific publications) and impact on the research field (e.g. citations). To face this issue, for each of the public AMCs we collect data about research productivity from bibliographic indexing databases (e.g. Web of Science, PubMed) and we retrieve structural information mainly from their official websites. This work has been partially financed by the research project “Leading Change in Academic Medical Centers”, funded by the competitive call for projects V:ALERE 2019. The project aims to provide evidence, advice, and remarks to help the agents of the public health system to address the many challenges that they face.

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Pierson, David. « AMC’s Mad Men and the Politics of Nostalgia ». Dans Media and Nostalgia, 139–51. London : Palgrave Macmillan UK, 2014. http://dx.doi.org/10.1057/9781137375889_11.

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Herman, Edward S. « From Ingsoc and Newspeak to Amcap, Amerigood, and Marketspeak ». Dans On "Nineteen Eighty-Four", sous la direction de Abbott Gleason, Jack Goldsmith et Martha C. Nussbaum, 112–24. Princeton : Princeton University Press, 2010. http://dx.doi.org/10.1515/9781400826643.112.

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Bishop, Kyle William. « Apocalyptic Psychotherapy : Emotion and Identity in AMC’s The Walking Dead ». Dans Emotions in Contemporary TV Series, 172–88. London : Palgrave Macmillan UK, 2016. http://dx.doi.org/10.1007/978-1-137-56885-4_11.

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Anand, V., M. N. Akshay, S. Abhilash et G. Deepak. « Recent Advances in the Development of Aluminium Matrix Composites (AMCs) ». Dans Lecture Notes in Mechanical Engineering, 619–26. Singapore : Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-32-9931-3_60.

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Zedel, Hannes, Robert Fritzsch, Shahid Akhtar et Ragnhild E. Aune. « Automated Metal Cleanliness Analyzer (AMCA)—An Alternative Assessment of Metal Cleanliness in Aluminum Melts ». Dans The Minerals, Metals & ; Materials Series, 778–84. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65396-5_102.

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Cheong, Shaw Mei, Mei-Teng Ling, Jane Wong Kon Ling et Saidatul Nornis Haji Mahali. « Rasch Analysis of Attitude and Motivation Towards Language Choice and Use of the Sabah Malay Dialect Instrument (AMCUSM) for Chinese Students in Sabah, Malaysia ». Dans Pacific Rim Objective Measurement Symposium (PROMS) 2016 Conference Proceedings, 141–51. Singapore : Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8138-5_11.

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Ferreira, L.-M. P., E. Bayraktar, I. Miskioglu et M.-H. Robert. « Design of Magnetic Aluminium (AA356) Composites (AMCs) Reinforced with Nano Fe3O4, and Recycled Nickel : Copper Particles ». Dans Mechanics of Composite, Hybrid and Multifunctional Materials, Volume 5, 93–100. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-95510-0_12.

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Zedel, Hannes, Robert Fritzsch, Shahid Akhtar et Ragnhild E. Aune. « Automated Metal Cleanliness Analyzer (AMCA) : Digital Image Analysis Phase Differentiation and Benchmarking Against PoDFA-Derived Cleanliness Data ». Dans The Minerals, Metals & ; Materials Series, 882–89. Cham : Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-22532-1_117.

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Choolani, M., H. O�Donnell, C. Campagnoli, S. Kumar, I. Roberts, P. Bennett et N. M. Fisk. « Using AMCA to Label the Fetal Cell Antigen in Fetal Erythroblasts Circumvents Heme Autofluorescence, Enhances cFISH Efficiency and Improves Specificity of Fetal Cell Identification ». Dans Fetal Cells and Fetal DNA in Maternal Blood, 74–81. Basel : KARGER, 2001. http://dx.doi.org/10.1159/000062520.

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Actes de conférences sur le sujet "AMCase"

He, CH, D. Hartl, CA Da Silva, RJ Homer, CG Lee et JA Elias. « Galectin-3 Binds to AMCase and Reciprocally Regulates Their Bioactivities. » Dans American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4951.

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Cote-Sierra, J., K. Huang, W. Danho, L. Gao, H. Hilton, J. Ventre, S. Tannu et al. « Lack of Efficacy of Acidic Mammalian Chitinase (AMCase) Inhibitors in Allergic Airway Inflammation. » Dans American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2243.

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Nikota, James K., Fernando M. Botelho, Carla M. Bauer, Nancy J. Trimble, Sussan Kianpour, Alison A. Humbles, Roland Kolbeck, Anthony J. Coyle et Martin R. Stämpfli. « BRP-39 But Not AMCase Is Increased In Murine Models Of Cigarette Smoke Exposure ». Dans American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2812.

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Dymek, Barbara, Piotr Sklepkiewicz, Magdalena Salamon, Anna Maria Zdziarska, Michał Mlącki, Agnieszka Zagożdżon, Robert Koralewski et al. « The therapeutic efficacy of OAT-889 (dual AMCase/CHIT1 inhibitor) in comparison to montelukast in HDM-induced model of chronic airway inflammation in mice ». Dans ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa4684.

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Zhang, Jia, Yuntao Guan, Xiaoxin Jiang, Haixin Duan et Jianping Wu. « AMCAS : An Automatic Malicious Code Analysis System ». Dans 2008 9th International Conference on Web-Age Information Management (WAIM). IEEE, 2008. http://dx.doi.org/10.1109/waim.2008.44.

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« AMCA 2010 Reviewers ». Dans 2010 IEEE 24th International Conference on Advanced Information Networking and Applications Workshops (WAINA). IEEE, 2010. http://dx.doi.org/10.1109/waina.2010.247.

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« AMCA 2010 Organizing Committee ». Dans 2010 IEEE 24th International Conference on Advanced Information Networking and Applications Workshops (WAINA). IEEE, 2010. http://dx.doi.org/10.1109/waina.2010.246.

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Xu, Zhirong, Shiyang Wen, Junshan Wang, Guojun Liu, Liang Wang, Zhi Yang, Lei Ding et al. « AMCAD : Adaptive Mixed-Curvature Representation based Advertisement Retrieval System ». Dans 2022 IEEE 38th International Conference on Data Engineering (ICDE). IEEE, 2022. http://dx.doi.org/10.1109/icde53745.2022.00323.

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Persteneva, Natalia Pavlovna, et Iuliia Borisovna Golub. « MULTIDIMENSIONAL MODELING OF THE russian mutual funds AMC's quality ». Dans Российская наука : актуальные исследования и разработки. Самара : Самарский государственный экономический университет, 2022. http://dx.doi.org/10.46554/russian.science-2022.02-2-112/116.

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Hapeez, Mohammad Shukri, Ngah Ramzi Hamzah, Azilah Saparon et Mustafar Kamal Hamzah. « Validating the precision of chromatogram obtained from AMCOS for automated HPLC ». Dans 2010 IEEE Symposium on Industrial Electronics and Applications (ISIEA 2010). IEEE, 2010. http://dx.doi.org/10.1109/isiea.2010.5679476.

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Rapports d'organisations sur le sujet "AMCase"

None, None. Plant-wide assessment summary : $3.6 million in savings identified in AMCAST assessment. Office of Scientific and Technical Information (OSTI), août 2004. http://dx.doi.org/10.2172/1216029.

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Buch, Jr, et George M. AMC's Future Strategic Airlifter : The Blended Wing Body ? Fort Belvoir, VA : Defense Technical Information Center, juin 2010. http://dx.doi.org/10.21236/ada526601.

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Bowyer, Brad P. Consolidating AMC's Contingency Response Capabilities : A Delphi Study. Fort Belvoir, VA : Defense Technical Information Center, juin 2015. http://dx.doi.org/10.21236/ada619574.

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HROMYAK, MICHELLE, ROBERT SINDELAR, CHRISTOPHER VERST, JOSHUA BOERSTLER et JOHN MICKALONIS. AUGMENTED MONITORING AND CONDITION ASSESSMENT PROGRAM (AMCAP) MATERIAL TEST REACTOR (MTR) FUEL INSPECTION PROGRAM REPORT. Office of Scientific and Technical Information (OSTI), août 2020. http://dx.doi.org/10.2172/1658843.

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Saylor, F., B. Tran et L. Ward. AUGMENTED MONITORING AND CONDITION ASSESSMENT PROGRAM (AMCAP) - PROOF-OF-PRINCIPLE (POP) MOCKUP FOR NON-ALUMINUM SPENT NUCLEAR FUEL CONTAINER IN-SITU EXAMINATIONS. Office of Scientific and Technical Information (OSTI), mars 2021. http://dx.doi.org/10.2172/1770289.

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Miller, Bryan E. Time To Take Action : A Plan to Improve AMC's Warfighting Support for the Combatant Commander by Re-Allocating C-17 Assets in Support of the White House Airlift Mission. Fort Belvoir, VA : Defense Technical Information Center, avril 2003. http://dx.doi.org/10.21236/ada424934.

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