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Articles de revues sur le sujet « American Manufacturing Co »

Auteur : Grafiati

Publié le 25 juillet 2024

Mis à jour le 31 juillet 2025

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1

Seclen Luna, Jean Pierre, and Pablo Moya Fernández. "Exploring the relationship between KIBS co-location and the innovativeness of the manufacturing firms in Latin America." Investigaciones Regionales - Journal of Regional Reserach 48 (October 19, 2020): 16. http://dx.doi.org/10.38191/iirr-jorr.20.021.

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Literature has provided empirical evidence showing the importance of location for understanding KIBS effective service provision. According to territorial servitization postulates KIBS are also fundamental for the development of the manufacturing firms. Despite KIBS can be an important source of innovation, limited attention is paid of KIBS in Latin America region. The purpose of this research is analysing the relationship between KIBS co-location and innovativeness of the manufacturing firms. Drawing on the World Bank Enterprise Survey 2017 for Latin-American countries, authors analyse 3,029

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Pelletier, Louis. "An experiment in ?historically correct? Canadian photoplays: Montreal's British American Film Manufacturing Co." Film History: An International Journal 19, no. 1 (2007): 34–48. http://dx.doi.org/10.2979/fil.2007.19.1.34.

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Sun Jae Won. "Pioneering Action for American Welfare Capitalism: Founder’s Challenge at the N. O. Nelson Manufacturing Co., 1886~1918." Review of Business History 32, no. 4 (2017): 209–22. http://dx.doi.org/10.22629/kabh.2017.32.4.009.

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GODLEY, ANDREW, MARRISA JOSEPH, and DAVID LESLIE-HUGHES. "Technology Transfer in the Interwar U.S. Pharmaceutical Sector: The Case of E. Merck of Darmstadt and Merck & Co., Rahway, New Jersey." Enterprise & Society 20, no. 3 (2019): 613–51. http://dx.doi.org/10.1017/eso.2018.97.

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This is a case study of the U.S. pharmaceutical producer, Merck & Co. By 1940 this was one of the leading pharmaceutical producers in the United States, and the company went on to become one of the global industry leaders after World War II. It was founded in 1891 as the U.S. subsidiary of a much larger German pharmaceutical company, E. Merck of Darmstadt. The existing understanding of Merck & Co.’s history emphasizes how it was reacquired by the American branch of the Merck family after wartime sequestration, and from then onward it pursued a path of development separate from its form

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Dawson, Patrick. "Australian technology meets American manufacturing: A case study of industrial collaboration." Human Factors and Ergonomics in Manufacturing 8, no. 2 (1998): 111–23. http://dx.doi.org/10.1002/(sici)1520-6564(199821)8:2<111::aid-hfm2>3.0.co;2-6.

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Matsumura, Takashi, and Norikazu Suzuki. "Special Issue on Recent Advanced Manufacturing Science and Technology." International Journal of Automation Technology 18, no. 4 (2024): 461–62. http://dx.doi.org/10.20965/ijat.2024.p0461.

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Recently, manufacturing technologies have progressed owing to high industrial demand. For example, in the automobile and aircraft industries, manufacturing processes require technologies that allow for high machining rates of lightweight and/or difficult-to-cut materials. Fabricating medical equipment involves the machining of biocompatible materials with high mechanical strength. Information devices require high-quality ultraprecision manufacturing processes. Furthermore, measurement and characterization technologies are also essential for manufacturing. Along with the evolution of manufactur

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Hem-Lee-Forsyth, Shivaughn, Bibiana Sandoval, and Hanna Bryant. "A tridimensional view of the Hispanic Health Paradox: Its relationship with faith, the enclave theory, and familism." Advances in Social Sciences Research Journal 8, no. 12 (2021): 317–45. http://dx.doi.org/10.14738/assrj.812.11476.

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This paper examines the "Hispanic (American) Health Paradox," the juxtaposition of Hispanics’ longer lifespan than the average American amid numerous inequities regarding social determinants of health. Hispanic Americans endure multiple health disparities with a higher incidence and prevalence of chronic conditions. They also experience multiple psychosocial and physical health challenges, including higher rates of food insecurity, poverty, segregation, discrimination, and limited or no access to medical care. Nevertheless, Hispanics enjoy better physical well-being and lower mortality rates w

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DAWSON, ANDREW. "Reassessing Henry Carey (1793–1879): The Problems of Writing Political Economy in Nineteenth-Century America." Journal of American Studies 34, no. 3 (2000): 465–85. http://dx.doi.org/10.1017/s0021875851006358.

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In April 1859 a group of well-to-do manufacturers and Republican politicians coaxed a reclusive Henry Carey, Philadelphia's pre-eminent economist, from his study to a public dinner in his honour. One hundred and twenty five names were at the foot of an invitation to dine at the opulent La Pierre Hotel in recognition of Carey's “service in behalf of American industrial interests.” The banqueting hall glittered with brilliantly illuminated chandeliers trimmed with floral arrangements; at one end a banner proclaimed “Protection to American Labor,” although, curiously, none of the guests looked as

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Larkin, Patrick S. "Job Satisfaction in Public Horticulture." HortScience 30, no. 4 (1995): 902B—902. http://dx.doi.org/10.21273/hortsci.30.4.902b.

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Much has been written about how job satisfaction may or may not affect production, morale, and quality of work. However, most job satisfaction studies have been conducted in the area of manufacturing and management, but none have been conducted in the field of public horticulture. Job satisfaction was examined in 245 employees from 30 public horticulture institutions in the mid-Atlantic region of the American Association of Botanic Gardens and Arboreta (AABGA) using the Job Descriptive Index (JDI) and Job in General (JIG). Our purpose was to determine if differences in job satisfaction existed

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Miyata, Kenichi, Hikaru Kondo, and Hiromichi Hasebe. "Emergent Dynamics of Cultural Innovation: Globalizing Pikachu through Japanese and American System, 1990-1999." Journal of Evolutionary Studies in Business 10, no. 2 (2025): 82–97. https://doi.org/10.1344/jesb.42474.

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Over the past decades, Japanese ‘soft power’ industries have obtained global popularity and attention for their new global media content. This was occurring while manufacturing sectors such as the electronics industry lost its international competitiveness after the financial bubble crisis in the early 1990s. In cultural studies, Japan’s growth of soft power attributed to a unique cultural business system through media franchising, called media mix, which created those popular media content. The main purpose of this article is to examine the emergence of this system, one that was founded on in

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Datta, Dipayan, S. G. Ramesh Kumar, M. B. Aswath Narayanan, A. Leena Selvamary, and A. Sujatha. "Emerging market of tobacco." International Journal Of Community Medicine And Public Health 5, no. 6 (2018): 2161. http://dx.doi.org/10.18203/2394-6040.ijcmph20182140.

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Tobacco industry throughout the world started growing larger and larger. Large firms like British American Tobacco, Imperial Tobacco, China National Tobacco Co. etc. have been manufacturing and exporting tremendous amount of tobacco products. But concurrent research works were also growing to investigate the ill impact of tobacco on health and environment. Since the mid-1960s, strong evidence of the lethal effects of tobacco consumption has led to a sharp decline in official support for producers and manufacturers of tobacco. As the industry is struggling with reduction in smoking rates, huge

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Nowak, Ireneusz, Adriana Nowak, and Aleksandra Leska. "Zgnilec amerykański jako choroba zakaźna pszczół miodnych – wybrane aspekty prawno-środowiskowe." Studia Prawno-Ekonomiczne 115 (September 29, 2020): 87–107. http://dx.doi.org/10.26485/10.26485/spe/2020/115/5.

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Przedmiot badań: Publikacja dotyczy problematyki związanej ze zwalczaniem choroby zakaźnej pszczół miodnych (Apis mellifera), jaką jest zgnilec amerykański (Paenibacillus larvae, American foulbrood, zgnilec złośliwy), w świetle polskich unormowań prawnych. Przedstawione rozważania obejmują co do zasady ustawę z dnia 11 marca 2004 r. o ochronie zdrowia zwierząt oraz zwalczaniu chorób zakaźnych zwierząt, a także rozporządzenie Ministra Rolnictwa i Rozwoju Wsi z dnia 11 lipca 2016 r. w sprawie zwalczania zgnilca amerykańskiego pszczół oraz Kodeks dobrej praktyki produkcyjnej w pszczelarstwie j

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Womack, Gabby C. "Racial Passing off the Record: A Journey in Reconnection and Navigating Shifting Identities." Genealogy 6, no. 1 (2022): 8. http://dx.doi.org/10.3390/genealogy6010008.

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Anyone of African descent or with African ancestry who engages in a genealogy project soon learns that the U.S. Census is a helpful yet frustrating tool. In 2016, equipped with my history degree and an online ancestry search engine, I searched for my great-grandfather Leroy in census records after I saw a picture of him as a young man at work in Philadelphia. This image would have been unremarkable had it not been for the fact that my African American ancestor was so light skinned that he seemed to blend in with his co-workers at Kramer’s Fruit and Vegetables. I thought there had to be a story

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Schoenfeld, Adam J., Alonso Villasmil Ocando, Zheng Ao, et al. "Abstract LB359: OBX-115 TIL from non-small cell lung cancer (NSCLC) are enriched for putative tumor-reactive, stem-like T cells with enhanced tumor cytotoxicity: Results from multimodal phenotyping analysis." Cancer Research 85, no. 8_Supplement_2 (2025): LB359. https://doi.org/10.1158/1538-7445.am2025-lb359.

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Abstract Background: Response to TIL cell therapy is associated with presence of tumor-reactive clonotypes in the infusion product (Chiffelle Immunity 2024, Dean SITC 2024). Incorporating 4-1BB agonism in the pre-rapid expansion protocol (pre-REP) phase of non-engineered TIL manufacturing has been shown to increase TIL expansion and enrich for putative tumor-specific T cells (Frank SITC 2021); TIL engineering and modifications of the REP process may further drive such enrichment. OBX-115 TIL are engineered with regulatable, membrane-bound interleukin 15 (mbIL15), a cytokine that supports expan

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Sriwangrach, Bunyawat. "A Contrastive Corpus-based Study of American and English Adjectives: ‘Important’ and ‘Significant’." Shanlax International Journal of Education 12, no. 2 (2024): 32–44. http://dx.doi.org/10.34293/education.v12i2.7227.

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This contrastive corpus-based study aims to analyze the similarities and differences of two synonyms “important” and “significant” concerning on the degree of formality in their distribution across genres as well as their collocations and semantic preference. The corpus data derived from the Corpus of Contemporary American English (COCA) and the British National Corpus (BNC) which represent varieties of English usage across different cultures (American and British). This study analyzed the top 20 noun collocates with Mutual Information (MI) scores value of at least three. The corpus data from

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Zenere, Giorgio, Carol Poortman, Afreen Sayed, et al. "Abstract 1791: Next generation UltraCAR-T® cells with intrinsic checkpoint inhibition and overnight manufacturing overcome suppressive tumor microenvironment leading to sustained antitumor activity." Cancer Research 83, no. 7_Supplement (2023): 1791. http://dx.doi.org/10.1158/1538-7445.am2023-1791.

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Abstract The UltraCAR-T® platform, with decentralized overnight manufacturing, has shifted the autologous CAR-T manufacturing paradigm. This disruptive approach has been validated in clinical and pre-clinical studies for both hematologic and solid tumors. UltraCAR-T cells, manufactured using an overnight process with minimal ex vivo manipulation of autologous T cells. UltraCAR-T cells are engineered to co-express CAR, membrane bound IL-15, and kill switch genes using non-viral gene transfer via high-throughput UltraPorator™ system. Multigenic design and overnight manufacturing renders UltraCAR

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Whitmal, Ayana. "Deriving a complex <em>BIN</em> through adverbial <em>BIN</em> complexes." Proceedings of the Linguistic Society of America 7, no. 1 (2022): 5288. http://dx.doi.org/10.3765/plsa.v7i1.5288.

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Work by Green (1998) discusses 3 sub-types of stressed BIN in African American English (AAE): stative, habitual, and completive. BIN constructions that co-occur with temporal adverbials exhibit limited grammaticality, with each sub-type differing in how they interact with these adverbials. Non-BIN constructions that involve multiple instances in the same clause of adverbials of the same class exhibit restrictions that resemble BIN + adverbial data. Drawing on works that analyze BIN as a remote past marker (Rickford 1975, Green 1998) and on works connecting adverbial position to interpretation

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Kruse, Elizabeth. "Doe v. Geller and Personal Jurisdiction Over Internet Activities." Texas A&M Law Review 12, no. 1 (2024): 407–29. https://doi.org/10.37419/lr.v12.i1.10.

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Personal jurisdiction is fundamental in American jurisprudence since it gives a court the power to bind parties with its ruling. Despite this subject’s mundane veneer, the concept is so complicated that it has inspired thousands of academic articles. A brief search on Westlaw under Law Reviews & Journals for the term “personal jurisdiction” yields nearly 10,000 results, while Lexis+ yields 14,662 for the same term. Even so, as the nature of human interaction has changed from in person, to in writing, to over the phone, and, most recently, to over the internet, the doctrine of personal juri

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Ramirez-Solis, Edgar. "Succession Planning and its Impact on Business Performance: A bibliometric Method to Identify Future Research in Family Firms." Journal of Global Entrepreneurial Management 1, no. 1 (2023): 1–12. http://dx.doi.org/10.59462/jgem.1.1.103.

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Our study employs a multifaceted bibliometric analysis to map the intellectual landscape of succession planning in family businesses and its impact on performance. It was based on articles from the Web of Science database from 2017 to 2023. Utilizing VOSviewer software for the analysis, various mapping techniques such as co-authorship networks, geographical dispersion, and keyword co-occurrence were deployed. The findings underscore an increasing scholarly interest in family business succession yet point out a waning emphasis on the planning aspects and their direct implications for business p

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Chan, Tim, Cheryl Bolinger, Sean Scott, et al. "Abstract 2821: Incorporation of intrinsic checkpoint blockade enhances functionality of multigenic autologous UltraCAR-T® cells manufactured using non-viral gene delivery and rapid manufacturing process." Cancer Research 82, no. 12_Supplement (2022): 2821. http://dx.doi.org/10.1158/1538-7445.am2022-2821.

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Abstract Current chimeric antigen receptor (CAR)-T manufacturing utilizes viral vectors and extensive ex vivo expansion at large central facilities leading to an exhausted CAR-T phenotype, high costs and long vein-to-vein times. While allogeneic CAR-T can reduce delays in patient treatment, they require extensive manipulation of donor cells, severe lymphodepletion and demonstrate short persistence limiting their therapeutic window. The UltraCAR-T® platform is designed to overcome these limitations by utilizing non-viral multigene delivery and a rapid, decentralized manufacturing process withou

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Lerner, Gabriel B. W., Gary G. Singer, Christopher P. Larsen, and Tiffany N. Caza. "Immunoglobulin-Negative Fibrillary Glomerulonephritis Masked in Diabetic Nephropathy: A Case Report and Discussion of a Diagnostic Pitfall." Glomerular Diseases 2, no. 2 (2021): 95–99. http://dx.doi.org/10.1159/000520071.

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<b><i>Introduction:</i></b> Fibrillary glomerulonephritis (FGN) is a rare glomerular disease with poor prognosis, characterized by deposition of randomly arranged fibrillar material measuring 10–30 nm in diameter. This diagnosis is confirmed with DNAJB9 immunohistochemistry as well as ultrastructural examination. Ultrastructurally, the fibrillary material seen in this entity may be confused with diabetic fibrillosis occurring in diabetic nephropathy. <b><i>Case Presentation:</i></b> We present a case of a 63-year-old African American male with re

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Wang, Ling, Shakir Hasan, Stephen Li, Michael Cohen, Deeqa Mahamed, and Christina Loh. "Abstract 3195: Advancing CAR T clinical development with high-parameter CyTOF technology." Cancer Research 85, no. 8_Supplement_1 (2025): 3195. https://doi.org/10.1158/1538-7445.am2025-3195.

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Abstract Adoptive immunotherapy using chimeric antigen receptor (CAR) T cells is considered a recent revolutionary treatment in cancer therapy. CAR T therapy has achieved great success in hematological B cell malignancies. However, it has faced significant challenges in solid tumors due to various factors, such as complex tumor microenvironments, restricted trafficking, impersistent antitumor activity and toxicities. A better understanding of CAR T biology will accelerate development of CAR T therapies with improved antitumor efficacy, durability and decreased toxicities. High-parameter flow c

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Bhojnagarwala, Pratik Sanjivkumar, Devivasha Bordoloi, Joshua Jose, and David B. Weiner. "Abstract LB141: In vivo co-produced BTEs targeting FSHR and Her2 overcome ovarian cancer therapeutic resistance in mice." Cancer Research 85, no. 8_Supplement_2 (2025): LB141. https://doi.org/10.1158/1538-7445.am2025-lb141.

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Abstract Ovarian cancer (OC) is a deadly disease in need of newer therapies. Several immunotherapy approaches including checkpoint inhibitors, cancer vaccines and CART cells have been explored for OC, with limited clinical success. Bispecific T cell engagers (BTEs) allow direct engagement of adaptive immunity, potentially making them important for OC. First-generation BTEs suffer from short half-lives, resulting in poor pharmacokinetics which reduces their effectiveness. BTEs also have complex manufacturing processes and stringent storage requirements, resulting in increased costs and potentia

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Korunka, Christian, and Pascale Carayon. "Continuous implementation of information technology: The development of an interview guide and a cross-national comparison of Austrian and American organizations." Human Factors and Ergonomics in Manufacturing 9, no. 2 (1999): 165–83. http://dx.doi.org/10.1002/(sici)1520-6564(199921)9:2<165::aid-hfm3>3.0.co;2-0.

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Lopez-Lago, Miguel A., Vikas Bhardwaj, Pravin Kesarwani, et al. "Abstract 3553: Bria-OTS+: A versatile therapeutic platform for inducing anti-cancer immunity." Cancer Research 85, no. 8_Supplement_1 (2025): 3553. https://doi.org/10.1158/1538-7445.am2025-3553.

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Abstract Background: Despite advances, achieving curative cancer therapies remains challenging due to the complex, multi-stage nature of the disease. Recently, therapeutic cancer vaccines have shown promising efficacy, driven by advances in immune profiling, antigen selection, immunotherapy combinations, mRNA technology, and delivery platforms. However, challenges persist, including identifying highly immunogenic tumor antigens, overcoming T-cell immune escape, and achieving scalable, cost-effective manufacturing. To address these, BriaCell is developing a gene-modified allogeneic tumor cell p

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Yellen, Benjamin. "Abstract 2760: Evaluation of functional heterogeneity in the potent responses of single CAR-T effector cells." Cancer Research 83, no. 7_Supplement (2023): 2760. http://dx.doi.org/10.1158/1538-7445.am2023-2760.

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Abstract Over the last decade, chimeric antigen receptor (CAR)-T cell immunotherapies have produced some miraculous cures in advanced stage, aggressive leukemias and lymphomas in both children and adults. However, many barriers continue to limit the availability and effectiveness of these therapies, including the lack of reliable potency assays for these cell-based “living” medicines. Unlike molecular medicines, which have well established manufacturing processes, cell based medicines are inherently heterogeneous, and each engineered lot of cells will inevitably have a distribution of growth p

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Yang, Cuiqing, Fuwei Jiang, Yifang Wang, et al. "Abstract 4087: Co-expression of membrane bound IL-15 enhanced anti-tumor response of CAR-T." Cancer Research 83, no. 7_Supplement (2023): 4087. http://dx.doi.org/10.1158/1538-7445.am2023-4087.

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Abstract Introduction: Chimeric antigen receptors (CARs) T cells have been used successfully to treat patients with hematologic malignancies, but showed less effective in solid tumors. We investigated multiple approaches to engineer and enhance CAR-T activity in solid tumors. It has been previously reported that improvement in the quality of CAR-T cells, through CAR design or manufacturing optimization, could enhance the therapeutic potential of CAR-T cells. One parameter influencing the effectiveness of CAR-T cell therapy is the differentiation status of the final product: CAR-T cells that ar

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Bunn, Marcus, Lindsay Bailey Steinitz, Vivek Chandra, et al. "Abstract 883: Scalable differentiation of cytotoxic natural killer (NK) cells from human pluripotent stem cells." Cancer Research 85, no. 8_Supplement_1 (2025): 883. https://doi.org/10.1158/1538-7445.am2025-883.

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Cell therapy is expanding as a treatment for various cancers. FDA-approved autologous therapies, such as chimeric antigen receptor (CAR) T cells and tumor infiltrating lymphocytes (TILs), are used for aggressive or late-stage cancers. However, these therapies face challenges due to lengthy manufacturing times and patient variability. Manufacturing is already a bottleneck, which is expected to worsen as these therapies are tested in earlier cancer stages and become available to more patients. An emerging solution for cancer treatment is the use of natural killer (NK) cells as an "off-the-shelf"

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Pransky, Joanne. "The Pransky interview: Dr Maja Matarić, Professor, University of Southern California; Pioneer, field of socially assistive robotics; co-founder of Embodied." Industrial Robot: the international journal of robotics research and application 46, no. 3 (2019): 332–36. http://dx.doi.org/10.1108/ir-04-2019-0069.

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Purpose The following paper is a “Q&A interview” conducted by Joanne Pransky of Industrial Robot Journal as a method to impart the combined technological, business and personal experience of a prominent, robotic industry PhD and innovator regarding her pioneering efforts and the challenges of bringing a technological invention to market. This paper aims to discuss these issues. Design/methodology/approach The interviewee is Dr Maja Matarić, Chan Soon-Shiong Distinguished Professor in the Computer Science Department, Neuroscience Program, and the Department of Pediatrics at the University o

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Varnavskii, V. "The Chinese Phenomenon of Economic Growth." World Economy and International Relations 66, no. 1 (2022): 5–15. http://dx.doi.org/10.20542/0131-2227-2022-66-1-5-15.

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Modern China should be considered as an unique experiment and great world project of human civilization, effectively a co-product of the Communist Party of China (CPC) and the West. The centuries-old concept of a free-market economy fell on fertile ground of the hardworking Chinese people and in a short historical period since the beginning of the reform has finally bore fruit. Globalization and digitalization have greatly helped the Chinese economy to expand around the world and have become powerful catalysts for Chinese economic development, providing it with new approaches to doing business

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Woolford, Andrew, Wanda June, and Sereyvothny Um. "“We Planted Rice and Killed People:” Symbiogenetic Destruction in the Cambodian Genocide." Genocide Studies and Prevention 15, no. 1 (2021): 44–67. http://dx.doi.org/10.5038/1911-9933.15.1.1805.

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In recent years, genocide scholars have given greater attention to the dangers posed by climate change for increasing the prevalence or intensity of genocide. Challenges related to forced migration, resource scarcity, famine, and other threats of the Anthropocene are identified as sources of present and future risk, especially for those committed to genocide prevention. We approach the connection between the natural and social aspects of genocide from a different angle. Our research emanates out of a North American Indigenous studies and new materialist rather than Euro-genocide studies framew

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Pedro, Kyle D., Rachel Burga, Alonso Villasmil Ocando, et al. "Abstract LB096: IL15-engineered tumor infiltrating lymphocytes (cytoTIL15TM) exhibit activity against autologous tumor cells from multiple solid tumor indications without IL2." Cancer Research 83, no. 8_Supplement (2023): LB096. http://dx.doi.org/10.1158/1538-7445.am2023-lb096.

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Abstract Tumor infiltrating lymphocyte (TIL) therapy has shown promising results in the treatment of metastatic melanoma. However, TIL therapy has conventionally required co-administration of IL2, which is associated with toxicity in patients. We previously showed that melanoma TILs engineered to express membrane-bound IL15 (mbIL15) under the control of the ligand acetazolamide (ACZ) can achieve IL2-independent expansion during manufacturing, antigen-independent persistence in vitro and anti-tumor efficacy in vivo. In the current study, we extend the cytoTIL15 cell therapy product concept to i

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Jeong, Joseph H., Young-Kyun Chang, You-Yeon Kang, et al. "Abstract LB090: IL-18 secreting chimeric antigen receptor T cells targeting glypican-3show superior persistence and antitumor immunity against hepatocellular carcinoma." Cancer Research 83, no. 8_Supplement (2023): LB090. http://dx.doi.org/10.1158/1538-7445.am2023-lb090.

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Abstract Over the last decade, immunotherapy has revolutionized the way we treat cancer primarily by boosting the body’s own immune system to help fight cancer. In particular, an engineered T cell therapy, namely chimeric antigen receptor (CAR) T cell therapy, is a more aggressive way to modify T cells to recognize cancer cells and destroy them. Although these CAR-T therapies have shown remarkable clinical responses in patients with hematological malignancies, their efficacy in solid tumor treatment has been disappointing due to many challenges: lack of tumor-specific antigen targets, loss of

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Certo, Michael, Christopher Baldeviano, Sharlene Adams, et al. "Abstract 581: bbT369, a dual-targeted and CBLB gene-edited autologous CART product, demonstrates anti-lymphoma activity in preclinical mouse models." Cancer Research 82, no. 12_Supplement (2022): 581. http://dx.doi.org/10.1158/1538-7445.am2022-581.

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Abstract Anti-CD19 CAR T cell therapies have improved outcomes for non-Hodgkin lymphoma (NHL) patients. However, only 30-40% of patients treated with commercially available CART cell therapies obtain long term remission, highlighting the need for more efficacious and durable therapies. Emerging clinical data suggest several failure modes for CD19 CAR T cell therapies: including loss or downregulation of CD19 antigen, loss of co-stimulation pathways on tumor cells, exhaustion of CAR-T cells, and immunosuppressive microenvironments. To overcome these hurdles, we devised the next-generation autol

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Haq, Naeem Ul, Hayat Mohammad Khan, Musawer Khan, Mohammad Ishaq, Muhammad Usman, and Gohar Ali. "Clinical Features and Surgical Management of Intracranial Meningioma’s in the Elderly." Scholars Journal of Applied Medical Sciences 10, no. 7 (2022): 1105–12. http://dx.doi.org/10.36347/sjams.2022.v10i07.011.

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Objective: Given the threat related with surgical intervention of intracranial meningiomas in the older population because of maturing physiology and numerous co morbidities, an endeavor was made to distinguish mediators impacting results and to characterize a category of individuals who ought not be surgically treated because of deprived prognosis. Study Setting: The study was conducted in neurosurgery unit mardan medical complex / bacha khan medical college Name of Hospital, Pakistan. Methods: The investigation of 58 individuals over the age of 70 years was conducted to determine short- and

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Abdou, Yara, E. Claire Dees, Joanne Mortimer, et al. "Abstract CT241: A phase 1, first-in-human (FIH) study of autologous anti-HER2 chimeric antigen receptor macrophage (CAR-M) in participants (pt) with HER2 overexpressing solid tumors." Cancer Research 83, no. 8_Supplement (2023): CT241. http://dx.doi.org/10.1158/1538-7445.am2023-ct241.

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Abstract Background: Macrophages are abundant in the solid tumor microenvironment (sTME) and can exhibit both pro- and anti-tumor functions. Macrophages can be redirected by CAR expression to phagocytose cancer cells in an antigen-specific manner. CAR-M can reprogram the sTME and present neoantigens to T cells, leading to epitope spreading and anti-tumor immunity. CT-0508 is comprised of autologous monocyte-derived proinflammatory macrophages expressing an anti-HER2 CAR. Pre-clinical studies showed that CT-0508 induced targeted cancer cell phagocytosis while sparing normal cells, decreased tum

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Roy, Jaydeep, Nga Tin Lin, Kronos Chow, et al. "Abstract 1326: Pre-clinical development of ARB011: A CDH17 targeting allogeneic nonviral RNA-based “Flash” CAR-NK therapy for gastrointestinal cancer." Cancer Research 84, no. 6_Supplement (2024): 1326. http://dx.doi.org/10.1158/1538-7445.am2024-1326.

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Abstract Background: Treatment for advanced gastrointestinal (GI) cancers has remained challenging, therefore, novel immunotherapies using chimeric antigen receptor (CAR)-T cells are being developed as a new hope for the patients. However, despite the clinical successes in hematologic malignancies, the overall safety and efficacy against solid tumors of CAR-T cells have yet to be established, and the manufacturing of autologous CAR-T cells requires lengthy cell expansion and viral transduction processes. In view of these technical challenges, we have developed ARB011, an RNA-based allogeneic C

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Sitrin, Jonathan, Lisa Marshall, Hai Tran, et al. "Abstract 1866: Discovery of mutation-independent EGFR degrading bispecific antibodies that suppress tumor growth in preclinical tumor models." Cancer Research 84, no. 6_Supplement (2024): 1866. http://dx.doi.org/10.1158/1538-7445.am2024-1866.

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Abstract Extracellular targeted protein degradation (eTPD) has emerged as a promising new drug modality focused on targeted elimination of extracellular and transmembrane proteins. In contrast to intracellular protein degraders, such as proteolysis targeting chimeras (PROTACs) and molecular glues which require ubiquitin-proteosome cellular degradation pathways, extracellular protein degraders can additionally harness endosomal-lysosomal protein degradation. Two recently published examples of extracellular protein degraders include AbTACs (antibody-based PROTAC) which co-engage a protein of int

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Mazhara, G. A. "Modeling of the Optimal Investment Portfolio Focused on Risk Minimization." Modern Economics 38, no. 1 (2023): 69–75. http://dx.doi.org/10.31521/modecon.v38(2023)-11.

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Abstract. Introduction. Portfolio optimization modelling is a study aimed at determining the best way to allocate an investor's funds between securities of different companies. The study uses a number of methods and approaches, such as: multicriteria optimization methods - optimization of criteria for minimum and maximum, modeling of the optimal stock portfolio with minimal risk, to determine the best way to allocate funds that will help investors achieve maximum return while minimizing risk. Purpose. There are a lot of publicly traded companies in the modern American stock market. Having chos

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Jung, Miyoung, Seung Min Kim, Eunsol Lee, et al. "Abstract 1324: Superior anti-tumor activity of GL205, an allogeneic anti-CD5 CAR-NK for treating T-cell malignancies." Cancer Research 84, no. 6_Supplement (2024): 1324. http://dx.doi.org/10.1158/1538-7445.am2024-1324.

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Abstract T cell malignancies are rare and intractable diseases with fewer treatment options and higher unmet needs compared to B-cell lymphomas. Chemotherapy such as CHOP has been used as the standard therapy for treatment of T cell malignancies, but clinical outcome is not a promising and alternative treatments are needed. Currently, Brentuximab Vedotin, an antibody-drug conjugate that targets CD30 is widely used for Hodgkin lymphoma, ALCL and CTCL. However, the application is limited to specific subtypes because CD30 expression is restricted to some subsets of T-cell lymphoma. CD5 is an attr

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Tyllis, Timona, Caitlin Abbott, Dylan McPeake, et al. "Abstract 3199: Development of a flow cytometry-based assay for measuring specific CAR expression on LGR5-targeting CAR-T cells." Cancer Research 83, no. 7_Supplement (2023): 3199. http://dx.doi.org/10.1158/1538-7445.am2023-3199.

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Abstract The measurement of chimeric antigen receptor (CAR) expression is critical for the development, qualification and quantitation of CAR-T cells for clinical applications. There is a comprehensive range of tools commercially available for specifically measuring expression of the CAR on CD19-targeting CAR-T cells. However, with the rapidly expanding repertoire of CAR-T cells in development targeting a diverse range of tumour antigens, there is a paucity of readily implementable assays that specifically measure CAR expression, which is essential for translation into the clinic. We have deve

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Lopez-Lago, Miguel A., Vikas Bhardwaj, Xiaoyi Zheng, et al. "Abstract 685: Engineering semi-allogeneic whole cancer vaccines with enhanced immunogenicity for the treatment of advanced solid tumors." Cancer Research 83, no. 7_Supplement (2023): 685. http://dx.doi.org/10.1158/1538-7445.am2023-685.

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Abstract Background: Therapeutic cancer vaccines are designed to program a patient’s own immune system to recognize and eliminate tumor cells. We sought to harness gene-modified tumor cells as a vaccine platform and developed cancer vaccines composed of breast cancer cells expressing GM-CSF (SV-BR-1-GM). We have recently reported favorable clinical outcomes in patient populations that match SV-BR-1-GM at one or more HLA alleles. Mechanistically, SV-BR-1-GM cells can directly activate CD4+ T-cells in an antigen-specific HLA-restricted manner, as demonstrated by an in vitro antigen presentation

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Bandara, Veronika, Batjargal Gundsambuu, Silvana Napoli, et al. "Abstract 4085: Development and in vitro validation of an LGR-5 targeting CAR-T against colorectal cancer." Cancer Research 83, no. 7_Supplement (2023): 4085. http://dx.doi.org/10.1158/1538-7445.am2023-4085.

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Abstract Chimeric antigen receptor (CAR) T cells have demonstrated robust clinical efficacy against B-cell malignancies, and rapid translation to approval for use in man has inspired the search for CAR-T cells against solid tumours. Cancer stem cells are a small population of cells within a tumour that have the capacity to self-renew, differentiate, and initiate new tumours. Cancer stem cells are known to be resistant to chemotherapy and radiotherapy and are enriched in residual disease, which allows relapse. Targeting cancer stem cells is desirable as it will reduce a tumours’ ability to gene

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Pransky, Joanne. "The Pransky interview: Dr Howard Chizeck, founder, Olis Robotics; Professor, Electrical and Computer Engineering, University of Washington." Industrial Robot: the international journal of robotics research and application 46, no. 4 (2019): 467–70. http://dx.doi.org/10.1108/ir-05-2019-0102.

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Purpose The following paper is a “Q&A interview” conducted by Joanne Pransky of Industrial Robot Journal as a method to impart the combined technological, business and personal experience of a prominent, robotic industry PhD and innovator regarding his pioneering efforts and his personal journey of bringing a technological invention to market. This paper aims to discuss these issues. Design/methodology/approach The interviewee is Dr Howard Chizeck, Professor of Electrical and Computer Engineering and Adjunct Professor of Bioengineering at the University of Washington (UW). Professor Chizec

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Rosoff, Nancy. "Climate in Crisis: Art and Activism at the Brooklyn Museum." Genocide Studies and Prevention 16, no. 1 (2022): 101–19. http://dx.doi.org/10.5038/1911-9933.16.1.1867.

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This paper explores the Brooklyn Museum’s activism-centered museum practice as exemplified by the exhibition Climate in Crisis: Environmental Change in the Indigenous Americas. The exhibition presents the collections of Indigenous art from North, Central, and South America through the lens of climate change and its impact on the survival of Indigenous people. The main thesis is that the current climate emergency is part of a longer history of environmental colonialism that began five hundred years ago. For millennia, Indigenous communities throughout the Americas have maintained profound and e

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Zheng, Suilan, Bo Huang, Sudarshan R. Kasireddy, et al. "Abstract 4798: In vivo generation of universal CAR T cells for targeting heterologous antigens in solid tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 4798. https://doi.org/10.1158/1538-7445.am2025-4798.

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Abstract The successes of autologous CAR T cell therapies in treating hematologic malignancies has spurred interest in applying the same approaches for treating solid tumors. However, challenges associated with antigen heterogeneity, CAR T cell exhaustion, cytokine release syndromes, high production costs, and manufacturing complexities have limited their use in solid tumors to date. To address these issues, we have developed a universal CAR expressing a single ScFv against fluorescein (FL) that together with fluorescein-containing bispecific adapters (tumor tags, TTs) can mediate engagement o

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Cotton, Graham, Chiara Saladino, Jennifer Thom, et al. "Abstract LB229: ALM-401: A first-in-class next generation bispecific ADC configured to deliver superior efficacy in selected solid tumor indications." Cancer Research 85, no. 8_Supplement_2 (2025): LB229. https://doi.org/10.1158/1538-7445.am2025-lb229.

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Abstract There is growing interest in exploiting bispecific approaches for the design of next generation ADCs to improve therapeutic efficacy, increase therapeutic window and overcome drug resistance. ALM-401 is a highly selective, engineered bispecific ADC (bsADC) Candidate Drug targeting the tumor associated antigens ROR1 and EGFR. ALM-401 is designed to deliver enhanced efficacy in solid tumor indications and an improved toxicity profile versus canonical ADCs to these clinically established targets. ROR1 and EGFR were identified as a top target pairing for a bsADC using a proprietary bioinf

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Hankey, Kim G., Tim Luetkens, Stephanie Avila, et al. "Eight-Day Point of Care CAR T-Cell Manufacturing on Clinimacs Prodigy from Healthy Donors As a Proof-of-Concept Study." Blood 138, Supplement 1 (2021): 2851. http://dx.doi.org/10.1182/blood-2021-154013.

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Abstract Introduction Chimeric Antigen Receptor (CAR) T-cell therapy has emerged as a powerful immunotherapy for various forms of cancer, especially hematologic malignancies. However, several factors limit use of CAR T-cells to a wider number of patients. Long manufacturing time (usually 3-4 weeks with standard of care products) poses a big challenge in treating these chemorefractory patients in a timely fashion. Thus, we evaluated the feasibility of a fresh in and fresh out, short, eight-day manufacturing process performed locally to expedite CAR T-cell drug product delivery. Herein we report

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Geirsson, Halldór, Thóra Árnadóttir, Sigrún Hreinsdóttir, et al. "Overview of results from continuous GPS observations in Iceland from 1995 to 2010." Jökull 60, no. 1 (2010): 3–22. http://dx.doi.org/10.33799/jokull2010.60.003.

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Iceland is a natural laboratory for a variety of processes associated with crustal deformation, such as earthquakes, magmatic events, tectonic plate motions, and glacial load changes. Continuous GPS (CGPS) measurements started in Iceland in 1995, and since then data from the network have helped to shed light on many different active deformation processes. The number of CGPS sites in Iceland tripled during 2006–2008, as a result of an international collaborative effort coordinated by Icelandic scientists. By early 2010 the number of CGPS stations in Iceland had reached 64, located primarily aro

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Wang, Meng, Iulian Pruteanu, Adam D. Cohen, et al. "Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors." Blood 134, Supplement_1 (2019): 622. http://dx.doi.org/10.1182/blood-2019-122513.

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CD19-specific chimeric antigen receptor (CAR) T cell therapies have been highly effective against B cell malignancies. We previously demonstrated that differential responses to anti-CD19 CAR T cell therapy in chronic lymphocytic leukemia (CLL) are associated with early memory T cell signature in apheresed, pre-manufacturing T-cells (CAR T-cell precursors). We tested the hypothesis that the composition of CAR-T precursor cells determines clinical efficacy in adult and pediatric Acute Lymphoblastic Leukemia (ALL), Non-Hodgkin's Lymphoma (NHL), Multiple Myeloma (MM), and CLL. Apheresed T cells we

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