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Littérature scientifique sur le sujet « And Nanocochleates »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "And Nanocochleates"

Harwalkar Mallappa S, Salunkhe Kishor S, Chintamani Ravindra B, and Raosaheb Sopanrao S. "Formulation and Evaluation of Lyophilized Nanocochleates of Paclitaxel – For Cancer Chemotherapy." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 2884–94. http://dx.doi.org/10.26452/ijrps.v11i3.2369.

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The nanocochleates are mainly prepared from the liposomes of active pharmaceutical ingredients (APIs) with the help of inactive ingredients like phosphatidylserine (PS) and calcium. The PS shows a considerable binding affinity towards calcium mainly due to the calcium’s tendency to lose part of its hydration shell and to displace water upon complexation. Due to neutralization of the electrostatic charge, calcium causes aggregation & fusion of liposomes composed PS with each other. It has been reported that ca++ has an affinity to form a more tightly packed & highly ordered and less hyd

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Samruddhi, More* Prajakta Kangutkar Shital Kamble Dr. D. R. Jadage. "Nanocochleates As a Novel Lipid-Based Nano Carrier for Enhanced Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1535–44. https://doi.org/10.5281/zenodo.15380480.

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As a type of lipid-based nanocarrier, nanocochleates have demonstrated great promise in improving drug delivery. They are made up of lipid bilayers that are rolled up into a cochleate structure, which provides a unique platform for encapsulating drugs. It has been demonstrated that nanocochleates improve drug stability, target specific tissues or cells, and provide controlled release of drugs. Because of their lipid-based composition, which makes them biocompatible and biodegradable, the use of nanocochleates for drug delivery has several benefits, such as increased efficacy, decreased side ef

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Kesharwani, Anubhav* Pandey Prince Ram Vishal. "Nanocochleates: A Novel Platform in Delivery Therapeutic Cargo." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3350–57. https://doi.org/10.5281/zenodo.15471652.

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This review article explores the exciting potential of nanocochleates as a novel drug delivery platform. Lipid-based drug delivery (LDDs) systems attract increasing interest in the pharmaceutical industry due to their advantages in solubility and bioavailability of poorly water-soluble drugs. Nanocochleates are the lipid based multi-layered spiral structure that resemble a small shell-like structure which is achieved through the interaction of negatively charged lipid and positively charged calcium ions which causes lipid bilayer to roll into cochlear-like structure. Due to these structures na

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Katoriya, V. S., G. S. Deokar, and S. J. Kshirsagar. "IONOTROPIC TRAPPING LECITHIN BASED CILOSTAZOL NANOCOCHLEATES FOR DRUG DELIVERY APPLICATIONS." INDIAN DRUGS 54, no. 09 (2017): 24–32. http://dx.doi.org/10.53879/id.54.09.10682.

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The nanocochleate drug delivery is based on encapsulating drugs in multilayered lipid crystal matrix (a cochleate) to potentially deliver the drug safely and effectively through the lipoidal membrane. Cilostazol is approved for the treatment of intermittent claudication and used as fibrinolytic agent, platelet aggregation inhibitor, bronchodilator agent, phosphodiesterase III Inhibitor and vasodilator agent. therefore, this drug delivery is suitable to deliver drug molecules into blood vessels. Formulations with lecithin showed good in vitro drug release, drug entrapment study results and the

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Sardar, Shelake* Aishwarya Ingrole Dr. Nilesh chougule. "Preparation Optimization And Evaluation Of Lenvatinib As A Nanocochleats." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 2136–42. https://doi.org/10.5281/zenodo.13131860.

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The objective of developing nanocochleates was to enhance drug bioavailability by improving solubility. Preformulation studies identified the drug and excipients through physical analysis methods. The drug's maximum wavelength was 254 nm in phosphate buffer pH 6.8, and 249 nm in methanol. Initially, liposomes were formed using the thin film hydration method, adjusting the cholesterol and lipid ratio. Subsequently, nanocochleates were produced using a trapping method. The formulation was optimized by considering the rotary evaporator speed, solvent system ratio and volume, hydration media pH, p

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GR1, Godge. "An Overview of Nanocochleates for Improving Oral Absorption Using a Phospolipid-Based Drug Delivery System." Bioequivalence & Bioavailability International Journal 8, no. 2 (2024): 1–11. http://dx.doi.org/10.23880/beba-16000236.

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A novel approach to oral and systemic drug delivery is nanaocochleate. It is a brand-new lipid-based system that offers a distinct technological platform appropriate for the systemic and oral delivery of numerous compounds with significant biologically therapeutic properties, such as medications, genes, and vaccine antigens. The technology of nanocochleate formulation is especially useful for hydrophobic macromolecules and small molecules with low oral bioavailability, as well as those that are negatively or positively charged. Research on the proof-of-principle of cochleate-mediated oral deli

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Vajir, Shaikh* Dipak Bade Anuradha Salunkhe Pravin Patil Omkar Bhagat Ajinkya Nalawade Shivanjali Shelake. "An Overview of Nanocochleates for Improving Oral Absorption of Antifungal Drugs Using a Phospolipid-Based Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2387–98. https://doi.org/10.5281/zenodo.15421913.

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Nanaocochleate is a unique method of systemic and oral medication delivery. It is a novel lipid-based system that provides a unique technical platform suitable for the oral and systemic delivery of several substances with important medically therapeutic qualities, including genes, vaccine antigens, and pharmaceuticals. Hydrophobic macromolecules, tiny compounds with low oral bioavailability, and negatively or positively charged molecules are particularly well-suited for the technique of nanocochleate formulation. Clinically relevant, well-established medications that are now only provided by i

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Tilawat, Meena, and Smita Bonde. "Nanocochleates: A potential drug delivery system." Journal of Molecular Liquids 334 (July 2021): 116115. http://dx.doi.org/10.1016/j.molliq.2021.116115.

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Munot, Neha, Ujjwala Kandekar, Prabhanjan S. Giram, Kavita Khot, Abhinandan Patil, and Simona Cavalu. "A Comparative Study of Quercetin-Loaded Nanocochleates and Liposomes: Formulation, Characterization, Assessment of Degradation and In Vitro Anticancer Potential." Pharmaceutics 14, no. 8 (2022): 1601. http://dx.doi.org/10.3390/pharmaceutics14081601.

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Quercetin, a flavonoid, has antioxidant and anti-inflammatory properties and the potential to inhibit the proliferation of cancer, but its therapeutic efficacy is lowered due to poor solubility and bioavailability. Quercetin-loaded nanocochleates (QN) were developed using a trapping method by the addition of calcium ions into preformed negatively charged liposomes (QL) prepared by a thin-film hydration method. Liposomes were optimized by varying the concentration of Dimyristoyl phosphatidyl glycerol and quercetin by applying D-optimal factorial design using Design-Expert® software. Stable rods

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VP, Rawal, and Gangurde SA. "Study of Nootropic Effect of Improved Nano Formulation Version of Levodopa in a Rat Model of Parkinson’s Disease Induced by 6-Hydroxydopamine." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1560–65. http://dx.doi.org/10.25258/ijddt.14.3.43.

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Background: More studies on Parkinson’s disease (PD) symptoms have demonstrated that the condition is multifaceted. PD is associated with cognitive problems & motor impairments, which lower quality of life. 6-hydroxydopamine is a common rodent Parkinsonism neurotoxin. 6-OHDA may damage neurons by increasing oxidative stress from hydroxyl radical production during autoxidation. 6-OHDA and oxidative stress have been shown to impair memory in rats. Thus, 6-OHDA mimics rat Parkinsonian and cognitive decline. Objective: To construct a stable and easily administered nano-formulation with enhance

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Thèses sur le sujet "And Nanocochleates"

Pham, Thi Thu Hanh. "Développement de nanocomplexes antileishmaniens lipidiques administrables par voie orale." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA114822.

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Ce travail porte sur la mise au point des nanocochléates intégrant à la fois l’amphotéricine B (AmB) et la miltéfosine (hexadécylphosphocholine, HePC) dotés de propriétés adéquates pour une administration par voie orale pour le traitement de la leishmaniose viscérale. Notre premier axe de recherche a été l’étude des interactions de l’AmB et de l’HePC avec les monocouches de lipides de DOPS (dioleoyl phosphatidylsérine) et de Cho (cholestérol) dans le développement de nanocochléates chargés avec ces deux principes actifs. Les résultats expérimentaux nous ont permis de déterminer le rapport drog

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Chapitres de livres sur le sujet "And Nanocochleates"

Panda, Parthasarathi, Monodip De, and Souvik Basak. "Nanocochleates." In Design and Applications of Theranostic Nanomedicines. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-89953-6.00006-4.

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Rub, Rukhsana, Neha Munot, and Akshay Wadate. "Determination of Improved Efficacy and Stability of Silymarin Loaded Nanocochleates Over Liposomes for the Treatment of Skin Diseases." In Current Aspects in Pharmaceutical Research and Development Vol. 6. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/caprd/v6/2148c.

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