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Thèses sur le sujet « And Therapeutic Applications »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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1

Dahm, Georges. "Metallocarbenes for therapeutic applications." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAE037.

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Les complexes métalliques des carbènes N-hétérocycliques (NHC) présentent un grand potentiel comme anticancéreux. En particulier, des études in vitro ont confirmés une cytotoxicité supérieure au cisplatine. Dans ce travail, nous avons introduit de la diversité moléculaire à de nouveaux complexes NHC-Pt par coordination de différents ligands NHC. Une deuxième stratégie, la post-fonctionnalisation de complexes de Pt a été étudié par : a) formation d’oxime, notamment avec une urée ciblant le PSMA, b) échange de ligand avec des polyamines hydrosolubles (PEI) ou des pnictogènes (phosphines, arsines

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2

Gordon, Nathaniel Charles. "Protease engineering for therapeutic applications." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648185.

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3

Di, Bari Ivana. "Photoresponsive nanosystems for therapeutic applications." Doctoral thesis, Università di Catania, 2019. http://hdl.handle.net/10761/4166.

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Oncological and bacterial diseases are certainly the most troubling illnesses of the twenty-first century, and the data in this regard are staggering. Indeed, anticancer chemotherapy is affected by low specificity/selectivity and undesired side effects, and drug resistance phenomena are responsible for the failure of many conventional treatments. Multidrug-resistant-bacteria (MDRB) infection is become another burden to modern healthcare. For such a reason, there is an increasing demand for the development of new strategies for anticancer and antibacterial treatments without antibiotics to save

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4

Miao, Tianxin. "Smart Synthetic Biomaterials for Therapeutic Applications." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/610.

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In the field of biomaterials, naturally-derived and synthetic polymers are utilized individually or in combination with each other, to create bio-inspired or biomimetic materials for various bioengineering applications, including drug delivery and tissue engineering. Natural polymers, such as proteins and polysaccharides, are advantageous due to low or non-toxicity, sustainable resources, innocuous byproducts, and cell-instructive properties. Synthetic polymers offer a variety of controlled chemical and physical characteristics, with enhanced mechanical properties. Together, natural and synthe

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5

Greasley, Sarah Louise. "Bioactive glass nanoparticles for therapeutic applications." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58227.

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There is great therapeutic potential for bioactive glass nanoparticles, as they can be internalised within cells and achieve sustained intracellular delivery of active ions. Bioactive glass nanoparticles are also used in nano-composites. The Stӧber process is commonly used for synthesising spherical silica particles. This thesis reports a comprehensive study of how the process variables can be systematically altered to obtain monodispersed particles of specific sizes in the range 20 – 500 nm. Modification of the Stӧber process so that the particles can contain cations such as calcium, which ca

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6

Grönwall, Caroline. "Affibody molecules for proteomic and therapeutic applications." Doctoral thesis, KTH, Molekylär Bioteknologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4674.

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This thesis describes generation and characterization of Affibody molecules with future applications in proteomics research, protein structure determinations, therapeutic treatment of disease and medical imaging for in vivo diagnostics. Affibody molecules are engineered affinity proteins developed by combinatorial protein engineering from the 58-residue protein A-derived Z domain scaffold. Novel Affibody molecules targeting human proteins were selected from a combinatorial library using phage display technology. In the first two investigations, an Affibody molecule specifically targeting the h

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7

Fornara, Andrea. "Multifunctional nanomaterials for diagnostic and therapeutic applications." Doctoral thesis, KTH, Funktionella material, FNM, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-26788.

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In the past few years, the use of nanostructured materials in medical applications hasdramatically increased, both in the research phase and for clinical purposes, due to thepeculiar properties and the ability of such materials to interact at a similar scale withbiological entities. In this thesis, we developed tailored magnetic multifunctionalnanoparticles for diagnostic and therapeutic applications, such as detection ofbiomolecules, simultaneous enhanced magnetic resonance imaging (MRI), fluorescentvisualization and controlled drug release.For sensitive and selective detection of specific bi

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8

Ekstrand, Vilhelm. "Therapeutic applications of acoustic and electromagnetic energy /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-126-1/.

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9

Carugo, Dario. "Development of microfluidic systems for therapeutic applications." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/348835/.

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The development of a microfluidic-based strategy is presented for investigating the functional behaviour of hydrogel spherical beads which are employed in the clinic as embolic agents and drug delivery systems for the treatment of hypervascularised tumours and arteriovenous malformations. For this purpose, biomimetic microchannel networks were designed and fabricated by micromilling technology. Microdevices architecture reproduced characteristic features of microcirculatory arteriolar systems. The miniaturisation allowed for coupling with microscope-based technology and in situ visualisation o

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10

Roberts, David John. "Peptide based conjugates for therapeutic delivery applications." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/peptide-based-conjugates-for-therapeutic-delivery-applications(76cee616-80bf-4b31-89d1-63f699573e78).html.

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The effect of peptide charge on the self-assembly and gelation behaviour of three octa-peptides: VEVKVEVK (VEK2), VKVKVEVK (VEK3) and VEVEVKVE (VEK1) has been investigated and characterised. The critical gelation concentration of each peptide was found to correlate with the charge modulus carried by the peptide and to be independent of the sign of the charge. Hydrogels formed were found to be transparent and stable when the peptide charge modulus is > 1. No differences in hydrogel structure or mechanical properties, as probed by TEM and SAXS and shear rheology, were found when the peptides wer

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11

Grönwall, Caroline. "Affibody molecules for proteomic and therapeutic applications /." Stockholm : School of Biotechnology, Royal Institute of Technology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4674.

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12

Singh, A. "Metal nanoparticles in therapeutic and sensor applications." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2533.

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13

Epasinghe, Don Jeevanie. "Applications of proanthocyanidin in dentistry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/197558.

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In dentistry, repair and restoration of tooth structure to regain its mechanical properties is the ultimate aim of caries management. Currently, preventive therapies are preferred to operative interference. New preventive approaches are necessary to treat dental caries. Dentine is composed of an organic matrix, consisting of type 1. Degradation of collagen matrix is the main reason for breakdown of resin-dentine bonds and development of secondary caries over time. Hence, preservation of collagen fibrils is essential for preventive and reparative procedures in minimum intervention dentistry.

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14

Hickey, A. J. "Pharmaceutical inhalation aerosols : their delivery and therapeutic applications." Thesis, Aston University, 2002. http://publications.aston.ac.uk/21776/.

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15

James, Hodari-Sadiki L. "Thermo-Responsive Polymers for Cell-Based Therapeutic Applications." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416231680.

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16

Bauer, Lisa. "Magnetic Nanoparticle Characterization for Imaging and Therapeutic Applications." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1458667742.

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17

Nisharnthi, Duggan. "Bioactive peptides for therapeutic applications in cardiovascular disease." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27810.

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Cardiovascular diseases including stroke are the leading cause of death and disability worldwide. The underlying pathology for most of these conditions is thrombosis, which is mediated by the coagulation cascade. Despite a wealth of clinically approved anticoagulants that target this pathway, there are currently no treatment options that provide the ideal safety and efficacy profile, with many imparting severe bleeding side effects. Furthermore, there are no approved therapeutics to treat the severe neuronal damage that occurs after stroke. Given the urgent need for novel and effective dru

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18

Mück-Häusl, Martin Andreas. "Genetic engineering of adenoviral vectors for improved therapeutic applications." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-138269.

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19

Ghorani, Behrouz. "Production and properties of electrospun webs for therapeutic applications." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590271.

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The electro spinning and properties of fibrous webs containing drugs, biomolecules and other potentially therapeutic compounds was studied. Two different technologies were investigated. The first dealt with incorporation and release of compounds including drugs using insoluble electrospun fibres comprised of cellulose acetate. A systematic parameter study was completed for producing electro spun cellulose acetate fibres that were substantially free of bead defects and the effect of different solvent systems and process parameters during electrospinning cellulose acetate were evaluated in respe

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20

Yu, Feifan. "Generating Affinity Proteins for Biotechnological, Diagnostic and Therapeutic Applications." Doctoral thesis, KTH, Proteinteknologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-164320.

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Protein engineering is a powerful tool to modify proteins to generate novel and desired properties that could be applied in biotechnological, diagnostics and therapeutic areas. In this thesis, both rational design and library based engineering principles have been exploited to develop affinity proteins with desired traits. One study was focused on the use of site-directed mutagenesis to obtain variants of the staphylococcal protein A-derived 58-residue immunoglobulin binding Z domain with improved affinity for mouse IgG1 Fc. Screening of ca. 170 constructed variants revealed one variant with a

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21

Kay, Richard D. "Complexes of functionalised polyamines with diagnostic and therapeutic applications." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342468.

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22

Camberlein, Virgyl. "Target-guided synthesis of metalloenzymes ligands with therapeutic applications." Thesis, Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILS004.

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La synthèse guidée par la cible de ligands protéiques est une stratégie innovante pour découvrir des composés bioactifs. En particulier, la Kinetic Target-Guided Synthesis (KTGS) and the Dynamic Combinatorial Chemistry (DCC) ont permis, ces dernières années, de découvrir des ligands originaux pour des cibles thérapeutiques mal explorées, ce qui a permis de lancer des projets de découverte de médicaments. Ce projet de thèse vise à utiliser la KTGS pour découvrir, puis optimiser des ligands de deux classes de métalloenzymes que sont les aminopeptidases du réticulum endoplasmiques (ERAP) et l’éla

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23

ageely, Eman. "Chemical Tools for Potential Therapeutic Applications of CRISPR Systems." OpenSIUC, 2020. https://opensiuc.lib.siu.edu/dissertations/1831.

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Clustered regularly interspaced short palindromic repeats (CRISPR) are derived from a bacterial and archaeal adaptive immune system. The core enzymes of CRISPR are RNA-guided endonucleases that sequence-specifically cleave foreign double-stranded DNA. Improving and controling the properties of the CRISPR system is a crucial step in advancing the therapeutic potential of CRISPR technology. Several classes of these enzymes exist and are being adapted for biotechnology, such as genome engineering. Cas12a (Cpf1) is a Type V CRISPR-associated (Cas) enzyme that naturally uses only one guide RNA, in

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24

Deodhar, Tejal Jayant. "Multifunctional Nanoparticles for Bio-analytical Applications and Therapeutic Delivery." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1367242624.

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25

Wijesiri, Niranga H. "Development of Nanoparticle – Based Hybrid Sensitizers for Therapeutic Applications." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593273291966287.

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26

Raggio, Rosasilvia. "Therapeutic silk fibroin-based systems for tissue engineering applications." Doctoral thesis, Università degli studi di Trento, 2019. http://hdl.handle.net/11572/243264.

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Tissue engineering (TE) is an interdisciplinary field, in continuous evolution, that possesses as main goal the creation of efficient systems for tissues and organs healing and regeneration. For bone, TE strategies are typically based on the combined use of scaffolds, cells, and bioactive molecules. Different materials were successfully studied and proposed for the fabrication of scaffolds. Among them, silk fibroin (SF) was evaluated as particularly promising for different TE applications, especially for bone tissue regeneration. Silk fibroin, a natural protein forming the structural core of

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Raggio, Rosasilvia. "Therapeutic silk fibroin-based systems for tissue engineering applications." Doctoral thesis, Università degli studi di Trento, 2019. http://hdl.handle.net/11572/243264.

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Tissue engineering (TE) is an interdisciplinary field, in continuous evolution, that possesses as main goal the creation of efficient systems for tissues and organs healing and regeneration. For bone, TE strategies are typically based on the combined use of scaffolds, cells, and bioactive molecules. Different materials were successfully studied and proposed for the fabrication of scaffolds. Among them, silk fibroin (SF) was evaluated as particularly promising for different TE applications, especially for bone tissue regeneration. Silk fibroin, a natural protein forming the structural core of

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28

Liesner, Raphael. "Mutational analysis of PhiC31 integrase to improve gene therapeutic applications." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-122432.

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29

Muñoz-Alarcón, Andrés. "Cell-penetrating peptides and oligonucleotides : Design, uptake and therapeutic applications." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-116049.

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Regulation of biological processes through the use of genetic elements is a central part of biological research and also holds great promise for future therapeutic applications. Oligonucleotides comprise a class of versatile biomolecules capable of modulating gene regulation. Gene therapy, the concept of introducing genetic elements in order to treat disease, presents a promising therapeutic strategy based on such macromolecular agents. Applications involving charged macromolecules such as nucleic acids require the development of the active pharmaceutical ingredient as well as efficient means

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30

Hull, E. A. "Antibody conjugates via disulfide bridging : towards therapeutic and diagnostic applications." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1461131/.

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Antibodies play a prominent role in chemical and biological research and the largest application of chemical bioconjugation reagents is in the production of antibody conjugates. These conjugates provide a means of highly sensitive detection, for example in enzyme-linked immunosorbent assay (ELISA) systems. In therapeutics, such conjugates have enabled the development of bispecifics and antibody-enzyme directed prodrug therapy (ADEPT). Long-established chemical modification techniques for the conjugation of antibodies yield highly heterogeneous products. This heterogeneity is far from optimal a

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31

Wong, Joseph Kwun-Hoi. "Cyclam and Metal-Cyclam Complexes for Sensing and Therapeutic Applications." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16312.

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A variety of cyclam and metal-cyclam-based systems have been investigated for potential in the sensing of metal ions or biological binding events, and antibacterial applications. In Chapter two, an efficient synthesis of 1,8-bis-(2-azidoethyl)cyclam has been developed and used to prepare 1,8-disubstituted cyclam conjugates. UV/visible and fluorescence emission spectra, zinc binding experiments, fluorescence quantum yield and lifetime measurements and pH titrations of the bis-naphthalimide ligands reveal complex photophysical behaviour and differences arising from the inclusion of two fluorop

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32

Burnight, Erin Rae. "Targeting therapeutic vector expression and integration for gene therapy applications." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2831.

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Gene therapy is an attractive treatment for many genetic diseases because rather than treat the symptoms of the disease, it has the potential to correct the underlying defect. Cystic fibrosis and hemophilia A are two monogenic disorders that are particularly well-suited to treatment with gene therapy as a relatively small increase in the function is needed to see improvement. Gene therapy has provided some correction in both diseases using a variety of vector systems but sustained expression and long term correction have y

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33

Greco, Arianna <1987&gt. "Synthesis of constrained peptidomimetics for therapeutic, diagnostic and theranostic applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7028/1/Greco_Arianna_Tesi.pdf.

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This thesis work deals, principally, with the development of different chemical protocols ranging from environmental sustainability peptide synthesis to asymmetric synthesis of modified tryptophans to a series of straightforward procedures for constraining peptide backbones without the need for a pre-formed scaffold. Much efforts have been dedicated to the structural analysis in a biomimetic environment, fundamental for predicting the in vivo conformation of compounds, as well as for giving a rationale to the experimentally determined bioactivity. The conformational analyses in solution has b

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Greco, Arianna <1987&gt. "Synthesis of constrained peptidomimetics for therapeutic, diagnostic and theranostic applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7028/.

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This thesis work deals, principally, with the development of different chemical protocols ranging from environmental sustainability peptide synthesis to asymmetric synthesis of modified tryptophans to a series of straightforward procedures for constraining peptide backbones without the need for a pre-formed scaffold. Much efforts have been dedicated to the structural analysis in a biomimetic environment, fundamental for predicting the in vivo conformation of compounds, as well as for giving a rationale to the experimentally determined bioactivity. The conformational analyses in solution has b

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35

ESPINOZA, L. M. J. FERREIRA. "ROLE OF IGE IN IMMUNOSURVEILLANCE: MECHANISM AND POTENTIAL THERAPEUTIC APPLICATIONS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/488915.

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IgE is the class of immunoglobulins responsible for the protection against intestinal parasites and exerts a key role in the pathophysiology of allergic reactions. In addition, it has been demonstrated its involvement in the immune response against tumors in various animal models. According to our model, the function of IgE in the anti-tumor response is mediated by the binding of IgE with its high affinity receptor FcεRI expressed, in mice, on the surface of mast cells and basophils. Activation of FcεRI receptor leads to cell degranulation with release of preformed and newly synthesized mediat

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Al-Ghamdi, Saleh. "Mechanisms associated with Staphylococcus aureus and Acanthamoeba interactions, and therapeutic applications." Thesis, University of Essex, 2016. http://repository.essex.ac.uk/17389/.

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Staphylococcus aureus is a major cause of infections within hospitals. Its spread among patients in hospitals is one of the major problems that require urgent attention. Staphylococcus aureus has the ability to interact with other microorganisms such as the free-living amoebae Acanthamoeba which acts as a host for various pathogens. This interaction is highly complex and may be beneficial to one of them or both. The main aims of this project were to study the interactions of Acanthamoeba castellanii with methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcu

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37

Economou, Mario A. "Uveal melanoma and macular degeneration : molecular biology and potential therapeutic applications /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-254-5/.

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38

Krysmann, Marta J. "Self-assembly of peptides and peptide based hybrids for therapeutic applications." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558793.

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A rich gallery of novel systems based on the sequence KLVFF (namely KLVFF, FFKLVFF, AAKLVFF, AAKLVAA, βAβAKLVFF, KLVFF-PEG, FFKLVFF-PEG, AAKLVFF-PEG, AAKLVAA-PEG, FF-PEG, FFFF-PEG) was synthesized and characterized. For the first time structure-properties relationships of this class of materials were systematically explored, with emphasis on self-association properties in both bulk and solution. Such a comparative investigation, essentially absent from the literature, provides insights into the underlying mechanism of amyloid fibrogenesis, given that KL VFF has been identified as critical for

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39

Gilmore, B. F. P. "Inhibitors and substrates of DPF IV and seprase : potential therapeutic applications." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403355.

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40

Ahsen, Osman Oguz. "Diagnostic and therapeutic devices and applications of endoscopic optical coherence tomography." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117806.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 154-171).<br>There is an increased demand for developing transformative technologies to satisfy unmet needs in the clinical management of a number of gastrointestinal (GI) tract diseases. With the maturation of sweptsource la

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VanGundy, Zachary Curtis. "Differentiation of regulatory myeloid cells and the potential for therapeutic applications." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405961624.

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Kandanapitiye, Murthi S. "Synthesis of Biocompatible Nanoparticulate Coordination Polymers for Diagnostic and Therapeutic Applications." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1429019837.

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Oroval, Cucarella María del Mar. "Design of novel bio-gated nanomaterials for sensing and therapeutic applications." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/78836.

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The present PhD thesis, entitled "Design of novel bio-gated nanomaterials for sensing and therapeutic applications", is focused on the design, preparation, characterization and evaluation of new smart hybrid organic-inorganic materials for their applications on the field of sensing and controlled drug delivery. The first chapter of this thesis introduces the concept of organic-inorganic hybrid materials containing switchable "gate-like" ensembles and their applications in the detection of chemical and biochemical species and as suitable materials for drug delivery applications. The seco

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44

Bagley, Alexander Francis. "Optically-Active Nanomaterials for Diagnostic and Therapeutic Applications in Ovarian Cancer." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11517.

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The clinical management of cancer has principally relied upon surgery, radiation therapy, and chemotherapy for many decades. Despite recent advances in molecularly-targeted diagnostic and therapeutic agents, the long-term survival rates in patients with solid malignancies including ovarian cancer have improved only incrementally. Nanotechnologies designed to locally interrogate and modulate the tumor microenvironment offer a promising opportunity to enhance existing treatment modalities and establish new therapeutic paradigms. By virtue of their elemental composition, geometry, and surface che

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45

Reimann, Sabine [Verfasser]. "Multivalent Dendritic Polyglycerol Anions for Diagnostic and Therapeutic Applications / Sabine Reimann." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1137206640/34.

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46

Aloisi, Adriano. "Nanoparticles based on different generation adamantane dendrons : design, synthesis and self-assembly studies." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF062.

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L’adamantane est un hydrocarbure polycyclique, rigide et assez encombrant. En médecine, plusieurs dérivés à base d’adamantane ont été développés notamment comme agent antiviraux. Facilement fonctionnalisés, sa conformation 3D permet d’amoindrir les encombrements stériques entre les différents groupements fonctionnels. Nous avons décidé d’utiliser ses propriétés pour concevoir des structures plus complexes, à savoir, des dendrons et des foldamers. Les dendrons sont des polymères synthétiques possédant des propriétés intéressantes. De par leurs tailles, ils sont considérés comme des nanoparticul

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47

Yamaguchi, Lydia Fumiko. "Potencial dos biflavonóides de Araucaria angustifolia (Bert.) O. Kuntze como antioxidantes e fotoprotetores." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-12072016-115252/.

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A Araucaria angustifolia é uma conífera endêmica das regiões sul e sudeste do Brasil sendo considerada uma espécie em extinção devido ao extenso extrativismo madeireiro. Atualmente, existem inúmeros projetos visando o reflorestamento e o uso sustentável deste pinheiro. Em vista destes pontos, o estudo das propriedades dos componentes das folhas com o intuito da utilização destes com fins comerciais tornou-se de extrema importância. As suas folhas foram submetidas à extração com solventes e foram identificados seis biflavonóides majoritários, dentre estes a amentoflavona e a ginkgetina, que são

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Svobodová, Markéta. "Selection of aptamers against prostate specific antigen for diagnostic and therapeutic applications." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/83492.

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Actualmente, el antígeno prostático específico (PSA) se considera el marcador más sensible para la detección de cáncer de próstata. Hasta la fecha anticuerpos monoclonales y policlonales se han utilizado para detectar el PSA debido a su alta especificidad y sensibilidad. Sin embargo, la producción de anticuerpos es lenta y cara. En el otro lado, los aptámeros con especificidad y afinidad iguales a los de los anticuerpos podría ser una forma alternativa para la detección de PSA. El objetivo de este trabajo es la selección de aptámeros contra el PSA. Aspectos fundamentales como la caracteriza

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Fellermeier, Sina [Verfasser], and Roland [Akademischer Betreuer] Kontermann. "Bifunctional immunostimulatory fusion proteins for therapeutic applications / Sina Fellermeier ; Betreuer: Roland Kontermann." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2016. http://d-nb.info/1124465960/34.

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Balasingham, Rebeca Glory. "Novel multi-metallic luminescent complexes towards dual-functional cellular and therapeutic applications." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/43088/.

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A series of novel multi-metallic luminescent Au(I) and Re(I) complexes have been synthesised targeting functionality as cellular imaging and/or therapeutic agents. Both the ligands and their complexes have been characterised by a variety of spectroscopic and spectrometric techniques. Several complexes were also characterised by X-ray crystal diffraction and/or elemental analysis. In both chapters two and three the modulation of the luminescent properties of a series of mono- and di-metallic [Re(CO)3(N^N)L]+ type complexes bearing functionalised alkyl chains by hydrophobically driven, intra- an

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