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1

P, Gilbert, Maillard J. -Y, and Godfree A. F, eds. Antibiotic and biocide resistance in bacteria. Blackwell Science, 2002.

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2

United States. Congress. Office of Technology Assessment, ed. Impacts of antibiotic-resistants bacteria. Office of Technology Assessment, Congress of the U.S., 1995.

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3

Amábile-Cuevas, Carlos F. Origin, evolution and spread of antibiotic resistance genes. R.G. Landes Co., 1993.

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4

Gravelle, Louise N. The antibiotic resistance of bacteria isolated from dental unit waterlines. Laurentian University, School of Graduate Studies, 2005.

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5

United States. Congress. Office of Technology Assessment., ed. Impacts of antibiotic-resistant bacteria: Thanks to penicillin-- He will come home! Office of Technology Assessment, Congress of the U.S., 1995.

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6

F, Amábile-Cuevas Carlos, ed. Antibiotic resistance: From molecular basics to therapeutic options. Chapman & Hall, 1996.

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7

Levy, Stuart B. The antibiotic paradox: How miracle drugs are destroying themiracle. Plenum Press, 1992.

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8

R, Fogarty Lisa, Oakland County (Mich.). Health Division., and Geological Survey (U.S.), eds. Antibiotic-resistant fecal bacteria, antibiotics, and mercury in surface waters of Oakland County, Michigan, 2005-2006. U.S. Dept. of the Interior, U.S. Geological Survey, 2007.

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9

R, Fogarty Lisa, Oakland County (Mich.). Health Division., and Geological Survey (U.S.), eds. Antibiotic-resistant fecal bacteria, antibiotics, and mercury in surface waters of Oakland County, Michigan, 2005-2006. U.S. Dept. of the Interior, U.S. Geological Survey, 2007.

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10

1935-, Tipper Donald J., ed. Antibiotic inhibitorsof bacterial cell wall biosynthesis. Pergamon, 1987.

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11

1935-, Tipper Donald J., ed. Antibiotic inhibitors of bacterial cell wall biosynthesis. Pergamon Press, 1987.

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12

Edgeworth, Jonathan. Antibiotic resistance in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0289.

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The two objectives of ensuring early appropriate antimicrobial treatment for septic patients on the intensive care unit (ICU), and limiting emergence and spread of antimicrobial resistance are both complicated and potentially conflicting. Increasingly unpredictable resistance, particularly amongst Gram-negative bacteria, through both local selection and transmission, and importation of globally successful resistant clones encourages the use of broad-spectrum empiric antimicrobials for septic patients, including in combination. This may lead to a vicious cycle whereby increasing antibiotic use
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13

Soulsby, Lord. Antimicrobial resistance: animal use of antibiotics. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0005.

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The evolution of resistance to microbes is one of the most significant problems in modern medicine, posing serious threats to human and animal health. The early work on the use of antibiotics to bacterial infections gave much hope that infectious diseases were no longer a problem, especially in the human field. However, as their use, indeed over use, progressed, resistance (both mono-resistance and multi-resistance), which was often transferable between different strains and species of bacteria, emerged. In addition, the situation is increasingly complex, as various mechanisms of resistance, i
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14

Hopkins, Susan. The international and national challenges faced in ensuring prudent use of antibiotics. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198758792.003.0001.

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In April 2014, the World Health Organization reinforced that without urgent coordinated action by most stakeholders the world is headed for a post-antibiotic era in which common infections and minor injuries, which have been treatable for decades, could kill once again. With the rise in the number of infections due to antibiotic-resistant bacteria and the lack of development of new antibiotics, antimicrobial resistance is a major clinical and public health issue that society needs to tackle. This chapter focuses on the challenges of drug resistance and antimicrobial development together with h
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15

Wilson, Mary E. Antibiotics. Oxford University Press, 2019. http://dx.doi.org/10.1093/wentk/9780190663414.001.0001.

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A STIRRING EXAMINATION OF A LOOMING CRISIS Virtually everyone has taken antibiotics. They can be lifesavers -- or they can be useless. But what are they? How are they used? And what happens as the effectiveness of antibiotics begins to decline? Antibiotics: What Everyone Needs to Know® examines the personal and societal implications of our planet's most important -- and arguably most overused -- medications. In a question-and-answer format, it unpacks the most complicated aspects of this issue, including: · How antibiotics are used (and overused) in humans, plants, and livestock · The conseque
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16

Kaushik, Sanket, and Nagendra Singh, eds. Current Developments in the Detection and Control of Multi Drug Resistance. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150498791220101.

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The rise in the incidence of infections is caused by multi drug resistant (MDR) bacteria, it is essential to elucidate the basic mechanism of antibiotic resistance to discover effective methods for diagnosis and treatment of infections. The use of pathogen-specific probes offers a faster alternative for pathogen detection and could improve the diagnosis of infection. High resolution melting analysis techniques are useful for the detection of multi drug resistant pathogens. Rational Structural Based Drug Design is a common method to identify a lead compound and take it forward for further devel
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17

Wilson, A. P. R., and Preet Panesar. Antimicrobial drugs in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0053.

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The pharmacokinetics of antimicrobials are altered in critically-ill patients, particularly in the presence of renal or hepatic failure. Maintaining a choice or diversity of antibiotics is important due to the emergence of resistance. Antibiotic use should also be kept to the minimum and local protocols need to be established. For community-acquired infection, co-amoxiclav or a parenteral cephalosporin can be used, while for hospital-acquired infection, piperacillin/tazobactam, ciprofloxacin, or ceftazidime are recommended. For suspected vascular catheter infection or methicillin-resistant Sta
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18

Amabile-Cuevas, Carlos F. Antibiotic Resistance. Eurekah.Com Inc, 2002.

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19

Gilbert. Antibiotic and Biocide Resistance in Bacteria. Blackwell Scientific Publications (BSP), 2002.

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20

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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21

Hughes, D., Diarmaid Hughes, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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22

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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23

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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24

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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25

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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26

Levy, Stuart B. Antibiotic Paradox. Hachette Books, 2002.

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27

Bañuls, Anne-Laure, Thi Van Ahn Nguyen, Quang Huy Nguyen, Thi Ngoc Anh Nguyen, Hoang Huy Tran, and Sylvain Godreuil. Antimicrobial resistance: the 70-year arms race between humans and bacteria. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789833.003.0006.

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Antimicrobial resistance started to become a human health issue in the 1940s, following the discovery of the first antibiotics. The golden age of antibiotics (the 1950s through 1970s) marked the beginning of the arms race between humans and bacteria. Antimicrobial resistance is now among the greatest threats to human health; occurring in every region of the world and with the potential to affect anyone, anywhere. We describe the main mechanisms of antimicrobial resistance, as well as how the bacteria evolve into “superbugs.” We detail the role of human activities on the emergence and spread of
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28

Phillips, Anthony. National Strategy and Action Plan for Combating Antibiotic Resistant Bacteria. Nova Science Publishers, Incorporated, 2015.

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29

Sillanpää, Mika, and Pardeep Singh. Degradations of Antibiotics and Antibiotic Resistance Bacteria from Various Sources. Elsevier Science & Technology Books, 2022.

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30

Sillanpää, Mika, and Pardeep Singh. Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources. Academic Press, 2022.

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31

Gertz, Alida. Tularemia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0067.

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Tularemia, caused by the gram-negative coccobacillus Francisella tularensis, is an extremely infectious bacterial zoonosis. Symptoms depend on site of exposure; they can be nonspecific and may include fever, lymphadenopathy, ulcer or papule, and nausea/vomiting. Natural transmission occurs via small mammals, such as rabbits, or arthropod bites. IV or IM antibiotics are preferred over oral forms. Supportive care is also critical; some patients may require respiratory support. If used as a biological weapon, aerosolized F. tularensis would be the most likely route of transmission. Clinical sympt
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32

Impacts of antibiotic-resistant bacteria: Thanks to penicillin-- He will come home! For sale by the U.S. G.P.O., Supt. of Docs, 1995.

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33

Amyes, Sebastian G. B. Bacteria: A Very Short Introduction. 2nd ed. Oxford University Press, 2022. http://dx.doi.org/10.1093/actrade/9780192895240.001.0001.

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Bacteria: A Very Short Introduction explores the nature of bacteria, which are the most abundant form of life on the planet. The first organisms to evolve, they include forms that can survive the toughest environments, from deep rocks to frozen wastes. No other organisms are as adaptable. We are most familiar with them as agents of disease, but benign bacteria are critical to ecosystems, as well as to human health. Bacteria play a significant role in the environment and in disease. We cannot ignore the growing resistance of bacteria to antibiotics.
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34

Oostdijk, Evelien, and Marc Bonten. Oral, nasopharyngeal, and gut decontamination in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0287.

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Many infections are caused by enteric bacilli, presumably from endogenous origin. Selective decontamination of the digestive tract (SDD) was developed to selectively eliminate the aerobic Gram-negative bacilli from the digestive tract, leaving the anaerobic flora unaffected. As an alternative to SDD, investigators have evaluated the effects of selective oropharyngeal decontamination (SOpD) alone. Most detailed data on the effects of SDD and SOpD in ICU-patients come from two studies performed in Dutch ICUs. The Dutch studies provide strong evidence that SDD and SOpD reduce ICUmortality, ICU-ac
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35

Levy, Stuart B. Antibiotic Paradox: How Miracle Drugs Are Destroying the Miracle. Springer London, Limited, 2013.

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36

Amabile-Cuevas, Carlos F. Antibiotic Resistance: From Molecular Basics to Therapeutic Options (Medical Intelligence Unit). Landes Bioscience, 1996.

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37

Amabile-Cuevas, Carlos F. Antibiotic Resistance: From Molecular Basics to Therapeutic Options (Medical Intelligence Unit). Springer, 1997.

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38

Peterson, Susan, and Staci Reintjes. Otitis Externa, Otitis Media, and Mastoiditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0011.

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Otitis Externa is an infection of external auditory canal. Infection typically occurs via penetration of the epithelial barrier. Patients typically present with inflammation of the auricle, external auditory canal, or outer tympanic membrane. First-line therapy includes topical acidic agents and antibiotic drops. Oral antibiotics should be considered for recurrent infections, those resistant to topical therapy, severe disease, extension beyond the external auditory canal, diabetics, or immunocompromised patients. Otitis Media is an infection of the middle ear. Patients typically present with o
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39

Amabile-Cuevas, Carlos F. Antibiotic Resistance: From Molecular Basics to Therapeutic Options (Medical Intelligence Unit Series). Landes Bioscience, 1997.

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40

Antibiotic-resistant fecal bacteria, antibiotics, and mercury in surface waters of Oakland County, Michigan, 2005-2006. U.S. Dept. of the Interior, U.S. Geological Survey, 2007.

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41

DeAugustinas, M., and A. Kiely. Periocular Infections. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0015.

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Periocular Infections occur when there is inflammation of the conjunctiva. Uncomplicated viral infections can usually be managed with careful hand hygiene and lubrication of the eye with artificial tears. More severe infections are notable for purulent discharge, membrane formation, and scarring, and can lead to corneal change. For suspected bacterial conjunctivitis, empiric therapy begins with broad spectrum antibiotic eye drops or ointment, which are supplemented with oral antibiotics in cases associated with pharyngitis and in children with H. influenzae infection. For gonococcal conjunctiv
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42

The Evolving Threat Of Antimicrobial Resistance Options For Action. World Health Organization, 2012.

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43

Perreten, Vincent. Distribution, molecular characterization and genetic mobilization of antibiotic resistance genes in enterococci, staphylococci and lactic acid bacteria isolated from food. 1995.

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44

Chastre, Jean. Diagnosis and management of nosocomial pneumonia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0117.

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Quantitative culture techniques, performed before the introduction of new antibiotics, enable physicians to identify most patients who need immediate treatment for nosocomial pneumonia, and help select optimal therapy in a safe, well-tolerated manner. These techniques avoid resorting to broad-spectrum coverage of all patients with a clinical suspicion of infection, and may minimize the emergence of resistant micro-organisms in the intensive care unit. However, the full impact of this decision tree on patient outcome remains controversial. Antimicrobial therapy of patients with nosocomial pneum
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45

Rello, Jordi, and Bárbara Borgatta. Pathophysiology of pneumonia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0115.

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Airway colonization, ventilator-associated tracheobronchitis (VAT), and hospital-acquired (HAP) and ventilator-associated pneumonia (VAP) are three manifestations having the presence of micro-organisms in airways in common. Newer definitions have to consider worsening of oxygenation, in addition to purulent respiratory secretions, chest-X rays opacities, and biomarkers of inflammation. Bacteria are the main causes of HAP/VAP. During hospitalization there’s a shift of airway’s colonizing flora from core organisms to enteric and non-fermentative ones. Macro- and micro-aspiration is the most impo
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46

News, PM Medical Health. 21st Century Complete Medical Guide to Antibiotics and Antibiotic Resistance, Drug-Resistant Bacteria, Antimicrobial Susceptibility, Authoritative CDC, ... for Patients and Physicians (CD-ROM). Progressive Management, 2004.

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47

Dondorp, Arjen M. Other tropical diseases in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0294.

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A wide range of tropical infectious diseases can cause critical illness. Knowledge of the local epidemiology where the disease is acquired is essential. In addition, local resistance patterns of common bacterial pathogens can be very different in tropical countries, so that antibiotic regimens might need adaptation. The ‘surviving sepsis’ guidelines are not always appropriate for the treatment of tropical sepsis. Both diseases require a more restricted fluid management. Leptospirosis is another important tropical disease that can cause sepsis with liver and renal failure or ARDS with pulmonary
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48

Redman, Nina E. Food Safety. ABC-CLIO, Inc., 2007. http://dx.doi.org/10.5040/9798216188100.

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This work is a detailed survey of food safety issues today, from E-coli contamination in fruits and vegetables to food production practices that increase antibiotic resistance. Is our food safe? Much of the corn, soybeans, and canola oil we eat has been genetically modified, but we don't know the long-term effects of GM foods on our health and the environment. We also consume antibiotic-resistant strains of bacteria through the meat we eat, and we face new threats like mad cow disease, avian flu, and bioterrorism. Food Safety: A Reference Handbook, Second Edition provides a broad, readable, an
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49

Chanmugam, Arjun S., and Gino Scalabrini. Urinary Tract Infections in Women. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0037.

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Urinary tract infections (UTIs) refer to a urine culture yielding a minimum of 100 to 10,000 bacteria units/mm of urine usually from a clean catch midstream sample. This can result from infection of the lower urinary tract involving the bladder (cystitis) or an infection of the upper urinary tract involving the kidneys (pyelonephritis). Uncomplicated UTIs occur in healthy, pre-menopausal, non-pregnant women with a normal urinary tract who have a high likelihood to respond favorably to treatment, but consider local antibiotic resistance patterns. Complicated UTIs occur in women with coexisting
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