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Articles de revues sur le sujet « Anticancer efficacy »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Kisiel-Nawrot, Ewa, Malgorzata Latocha, Andrzej Bak, Violetta Kozik, Josef Jampilek, and Andrzej Zieba. "Anticancer Efficacy of Antibacterial Quinobenzothiazines." Applied Sciences 13, no. 5 (2023): 2886. http://dx.doi.org/10.3390/app13052886.

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The antitumor potency of a series of designed and prepared antibacterial quinobenzothiazines was evaluated against different types of human cancer cell lines, such as glioblastoma SNB-19, lung adenocarcinoma A549 and breast cancer T47D, and the activities of the compounds were compared to cisplatin and doxorubicin. 9-Propoxy-5-methyl-12H-quino[3,4-b][1,4]benzo- thiazinium chloride (4a), 9-allyloxy-5-methyl-12H-quino[3,4-b][1,4]benzothiazinium chloride (4d) and 11-benzyloxy-5-methyl-12H-quino[3,4-b][1,4]benzothiazinium chloride (4l) were the most active compounds; their IC50 values against all

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Farashi-Bonab, Samad, and Nemat Khansari. "Salmonella-based Anticancer Vaccines and their Efficacy." Vaccination Research – Open Journal 4, no. 1 (2019): 5–11. http://dx.doi.org/10.17140/vroj-4-111.

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Surgery, chemotherapy, and radiotherapy are successfully used to treat patients with tumors or cancers. However, the innovation of more potent therapeutic modalities is essential for the efficient treatment of patients with advanced cancers. More than two centuries ago, bacteria have been observed to have beneficial effects in some cancer patients. Virulence factors of some bacteria and their infectious behavior in the body suggest their effectiveness in tumor suppression. At present, bacillus calmette-guérin (BCG), a live attenuated strain of Mycobacterium bovis, is currently used to treat bl

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Niedzwiecki, Aleksandra, Mohd Roomi, Tatiana Kalinovsky, and Matthias Rath. "Anticancer Efficacy of Polyphenols and Their Combinations." Nutrients 8, no. 9 (2016): 552. http://dx.doi.org/10.3390/nu8090552.

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Sun, Shi-Yong. "Enhancing perifosine's anticancer efficacy by preventing autophagy." Autophagy 6, no. 1 (2010): 184–85. http://dx.doi.org/10.4161/auto.6.1.10816.

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Fu, Chih-Wei, Yun-Jung Hsieh, Tzu Ting Chang, et al. "Anticancer efficacy of unique pyridine-based tetraindoles." European Journal of Medicinal Chemistry 104 (November 2015): 165–76. http://dx.doi.org/10.1016/j.ejmech.2015.09.032.

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Alven, Sibusiso, and Blessing Atim Aderibigbe. "The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment." Pharmaceutics 12, no. 12 (2020): 1212. http://dx.doi.org/10.3390/pharmaceutics12121212.

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Breast cancer is among the most common types of cancer in women and it is the cause of a high rate of mortality globally. The use of anticancer drugs is the standard treatment approach used for this type of cancer. However, most of these drugs are limited by multi-drug resistance, drug toxicity, poor drug bioavailability, low water solubility, poor pharmacokinetics, etc. To overcome multi-drug resistance, combinations of two or more anticancer drugs are used. However, the combination of two or more anticancer drugs produce toxic side effects. Micelles and dendrimers are promising drug delivery

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Li, Fan, Xinqing Fu, Qingqing Huo, and Wantao Chen. "Research Progress on the Nano-Delivery Systems of Antitumor Drugs." Nano LIFE 10, no. 01n02 (2020): 2040006. http://dx.doi.org/10.1142/s1793984420400061.

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To date, chemotherapy, the main treatment for malignant tumors, still fails to provide ideal therapeutic efficacy, which is deeply rooted in various physiological barriers, either temporal or spatial, to the delivering of anticancer drugs to solid tumor sites during chemotherapy. In the meantime, the therapeutic efficacy of anticancer drugs is affected by inherent cancer characteristics, drug transport, cellular uptake and other complex interactions. Recently, advances have been constantly achieved on nanoscale drug delivery systems (NDDSs) for anticancer drug delivery, driven by their excelle

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Xu, Tengyan, Chunhui Liang, Debin Zheng, et al. "Nuclear delivery of dual anticancer drug-based nanomedicine constructed by cisplatinum-induced peptide self-assembly." Nanoscale 12, no. 28 (2020): 15275–82. http://dx.doi.org/10.1039/d0nr00143k.

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Verma, Poonam, Sanjukta Naik, Pranati Nanda, Silvi Banerjee, Satyanarayan Naik, and Amit Ghosh. "In Vitro Anticancer Activity of Virgin Coconut Oil and its Fractions in Liver and Oral Cancer Cells." Anti-Cancer Agents in Medicinal Chemistry 19, no. 18 (2020): 2223–30. http://dx.doi.org/10.2174/1871520619666191021160752.

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Background: Coconut oil is an edible oil obtained from fresh, mature coconut kernels. Few studies have reported the anticancer role of coconut oil. The fatty acid component of coconut oil directly targets the liver by portal circulation and as chylomicron via lymph. However, the anti-cancer activity of coconut oil against liver cancer cells and oral cancer cells is yet to be tested. The active component of coconut oil, that is responsible for the anticancer activity is not well understood. In this study, three different coconut oils, Virgin Coconut Oil (VCO), Processed Coconut Oil (PCO) and Fr

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Safwat, Mohamed A., Bothaina A. Kandil, Mohamed A. Elblbesy, Ghareb M. Soliman, and Nermin E. Eleraky. "Epigallocatechin-3-Gallate-Loaded Gold Nanoparticles: Preparation and Evaluation of Anticancer Efficacy in Ehrlich Tumor-Bearing Mice." Pharmaceuticals 13, no. 9 (2020): 254. http://dx.doi.org/10.3390/ph13090254.

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Epigallocatechin-3-gallate (EGCG) is a pleiotropic compound with anticancer, anti-inflammatory, and antioxidant properties. To enhance EGCG anticancer efficacy, it was loaded onto gold nanoparticles (GNPs). EGCG-GNPs were prepared by a simple green synthesis method and were evaluated using different techniques. Hemocompatibility with human blood and in vivo anticancer efficacy in Ehrlich ascites carcinoma-bearing mice were evaluated. EGCG/gold chloride molar ratio had a marked effect on the formation and properties of EGCG-GNPs where well-dispersed spherical nanoparticles were obtained at a mo

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Mafe, Alice N., and Dietrich Büsselberg. "Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug." Biomedicines 13, no. 2 (2025): 422. https://doi.org/10.3390/biomedicines13020422.

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The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on the role of microbiome integrity in enhancing the efficacy and safety of anticancer drug therapy, emphasizing the pharmacokinetic interactions between anticancer drugs and the gut microbiota. It explores how disruptions to microbiome composition, or dysbiosis, can alter drug metabolism, immune responses, and treatment side effects. By examining the mechanisms of microbiome disruption caused by anticancer drugs, this paper highlights specific case studies

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Thanasak, Jitkamol, Sittiruk Roytrakul, Rudee Surarit, et al. "Anticancer properties of peptides and protein hydrolysates derived from Asian water monitor (Varanus salvator) serum." PLOS ONE 20, no. 4 (2025): e0321531. https://doi.org/10.1371/journal.pone.0321531.

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This study investigated the anticancer efficacy of <3 kDa fractions derived from native peptides and protein hydrolysate of Varanus saltator serum. The inhibitory effects of these fractions were evaluated against a panel of cancer cell lines (A375, CaCO2, CAL27, NCI-H460, HeLa, HCT8, HT29, HepG2, KATO III, MCF-7, MDA-MB-231, Raw264.7, SKOV-3, SW620, T47D, and U937) and normal cell lines (HaCaT, MRC5, and Vero). Native peptides demonstrated higher anticancer activity compared to protein hydrolysates, inhibiting 16 cell lines and exhibiting high efficacy (≥70% inhibition) against CaCO2, CAL27

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Wang, Yan, Wei Xie, Juliette Humeau, et al. "Autophagy induction by thiostrepton improves the efficacy of immunogenic chemotherapy." Journal for ImmunoTherapy of Cancer 8, no. 1 (2020): e000462. http://dx.doi.org/10.1136/jitc-2019-000462.

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BackgroundImmunogenic cell death (ICD) is a peculiar modality of cellular demise that elicits adaptive immune responses and triggers T cell-dependent immunity.MethodsFluorescent biosensors were employed for an unbiased drug screen approach aiming at the identification of ICD enhancers.ResultsHere, we discovered thiostrepton as an enhancer of ICD able to boost chemotherapy-induced ATP release, calreticulin exposure and high-mobility group box 1 exodus. Moreover, thiostrepton enhanced anticancer immune responses of oxaliplatin (OXA) in vivo in immunocompetent mice, yet failed to do so in immunod

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Garattini, S. "Efficacy, safety, and cost of new anticancer drugs." BMJ 325, no. 7358 (2002): 269–71. http://dx.doi.org/10.1136/bmj.325.7358.269.

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Calvert, H. "Efficacy, safety, and cost of new anticancer drugs." BMJ 325, no. 7375 (2002): 1302a—1302. http://dx.doi.org/10.1136/bmj.325.7375.1302/a.

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Sharma, Nikita, Monisha Singhal, R. Mankamna Kumari, et al. "Diosgenin Loaded Polymeric Nanoparticles with Potential Anticancer Efficacy." Biomolecules 10, no. 12 (2020): 1679. http://dx.doi.org/10.3390/biom10121679.

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This study aims to determine the anticancer efficacy of diosgenin encapsulated poly-glycerol malate co-dodecanedioate (PGMD) nanoparticles. Diosgenin loaded PGMD nanoparticles (variants 7:3 and 6:4) were synthesized by the nanoprecipitation method. The synthesis of PGMD nanoparticles was systematically optimized employing the Box-Behnken design and taking into account the influence of various independent variables such as concentrations of each PGMD, diosgenin and PF-68 on the responses such as size and PDI of the particles. Mathematical modeling was done using the Quadratic second order model

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Nazari-Vanani, R., K. Karimian, N. Azarpira, and H. Heli. "Capecitabine-loaded nanoniosomes and evaluation of anticancer efficacy." Artificial Cells, Nanomedicine, and Biotechnology 47, no. 1 (2019): 420–26. http://dx.doi.org/10.1080/21691401.2018.1559179.

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Gaspar, Diana, Ana Salomé Veiga, Chomdao Sinthuvanich, Joel P. Schneider, and Miguel A. R. B. Castanho. "Anticancer Peptide SVS-1: Efficacy Precedes Membrane Neutralization." Biochemistry 51, no. 32 (2012): 6263–65. http://dx.doi.org/10.1021/bi300836r.

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Konstantinov, S. M., R. Kaminsky, R. Brun, M. R. Berger, and U. Zillmann. "Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies." Acta Tropica 64, no. 3-4 (1997): 145–54. http://dx.doi.org/10.1016/s0001-706x(96)00628-6.

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Deutsch, Eric, Cyrus Chargari, Lorenzo Galluzzi, and Guido Kroemer. "Optimising efficacy and reducing toxicity of anticancer radioimmunotherapy." Lancet Oncology 20, no. 8 (2019): e452-e463. http://dx.doi.org/10.1016/s1470-2045(19)30171-8.

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Conforti, F., and L. Pala. "Sex-based heterogeneity of efficacy of anticancer immunotherapy." Annals of Oncology 30 (October 2019): v522—v523. http://dx.doi.org/10.1093/annonc/mdz253.110.

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Hampton, Tracy. "Newly Designed Protein Augments Efficacy of Anticancer Antibodies." JAMA 310, no. 1 (2013): 22. http://dx.doi.org/10.1001/jama.2013.7878.

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Sakamoto, Junichi, Koji Oba, Takanori Matsui, and Michiya Kobayashi. "Efficacy of Oral Anticancer Agents for Colorectal Cancer." Diseases of the Colon & Rectum 49 (October 2006): S82—S91. http://dx.doi.org/10.1007/s10350-006-0601-7.

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Shah, Hassan, Asadullah Madni, Nina Filipczak, et al. "Cisplatin-loaded thermoresponsive liposomes for enhanced anticancer efficacy." Journal of Drug Delivery Science and Technology 84 (June 2023): 104509. http://dx.doi.org/10.1016/j.jddst.2023.104509.

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Naumenko, V. A., A. S. Garanina, S. S. Vodopyanov, et al. "Magnetic resonance imaging for predicting personalized antitumor nanomedicine efficacy." NANOMEDICINE, no. 6 (December 30, 2018): 21–24. http://dx.doi.org/10.24075/brsmu.2018.086.

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Magnetic resonance imaging (MRI) is widely used to diagnose cancer and study patterns and effectiveness of nanocarrier delivery of anticancer drugs. Accumulation of nanoparticles in a tumor varies widely in a given population; it is also highly dependent on biological factors, which remain largely unstudied. In recent years, there was developed a hypothesis that suggests that MRI can be used to predict response to nanoformulations-based anticancer therapy since it provides data on accumulation of MRI contrast agents in the tumor. Pilot tests prove feasibility of the approach based on this hypo

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Tikhomirova, A. V. "Criteria for Evaluation of Clinical Efficacy of Anticancer Medicines." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 9, no. 1 (2019): 34–40. http://dx.doi.org/10.30895/1991-2919-2019-9-1-34-40.

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Criteria for evaluation of clinical efficacy make it possible to assess the risk-benefit ratio of anticancer medicines that patients receive, in particular, for the treatment of solid malignant tumors. A medicine’s efficacy is assessed using special criteria called the endpoints of clinical efficacy, allowing most objective assessment of study results. It was demonstrated that nowadays clinical efficacy of anticancer drugs is assessed using «patient-centered» (overall survival and quality of life) and «tumor-centered» (response to therapy, progression-free survival, disease-free survival) endp

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Wang, Pu, Jinxiu Wang, Haowen Tan, et al. "Acid- and reduction-sensitive micelles for improving the drug delivery efficacy for pancreatic cancer therapy." Biomaterials Science 6, no. 5 (2018): 1262–70. http://dx.doi.org/10.1039/c7bm01051f.

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Kochenderfer, J. N., and R. E. Gress. "A Comparison and Critical Analysis of Preclinical Anticancer Vaccination Strategies." Experimental Biology and Medicine 232, no. 9 (2007): 1130–41. http://dx.doi.org/10.3181/0702-mr-42.

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Anticancer vaccines have been extensively studied in animal models and in clinical trials. While vaccination can lead to tumor protection in numerous murine models, objective tumor regressions after anticancer vaccination in clinical trials have been rare. B16 is a poorly immunogenic murine melanoma that has been extensively used in anticancer vaccination experiments. Because B16 has been widely used, different vaccination strategies can be compared. We reviewed the results obtained when B16 was treated with five common vaccine types: recombinant viral vaccines, DNA vaccines, dendritic cell va

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Kim, Tae Hun, Dong Hoon Suh, Mi-Kyung Kim, and Yong Sang Song. "Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/132702.

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Ovarian cancer is the most lethal gynecologic malignancy among women worldwide and is presumed to result from the presence of ovarian cancer stem cells. To overcome the limitation of current anticancer agents, another anticancer strategy is necessary to effectively target cancer stem cells in ovarian cancer. In many types of malignancies, including ovarian cancer, metformin, one of the most popular antidiabetic drugs, has been demonstrated to exhibit chemopreventive and anticancer efficacy with respect to incidence and overall survival rates. Thus, the metabolic reprogramming of cancer and can

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Khan, Mahir, Ryan Huu-Tuan Nguyen, James Love, et al. "Safety and efficacy of COVID-19 vaccination in patients receiving systemic anticancer therapy." Journal of Clinical Oncology 39, no. 28_suppl (2021): 245. http://dx.doi.org/10.1200/jco.2020.39.28_suppl.245.

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245 Background: Patients with cancer who have been treated with systemic anticancer therapy are at increased risk of morbidity and mortality from COVID-19 and have been considered a high-priority group for COVID-19 vaccination in the United States. There is limited guidance and data on the appropriate timing of COVID-19 vaccination relative to receipt of systemic anticancer therapy. Methods: We queried the electronic medical record at the University of Illinois Hospital for patients with gastrointestinal, breast, lung, genitourinary, and head and neck tumors who had received intravenous system

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Yoon, Wonsuck, Yongsung Park, Seunghyun Kim, Yongkeun Park, and Chul Yong Kim. "Combined Therapy with microRNA-Expressing Salmonella and Irradiation in Melanoma." Microorganisms 9, no. 11 (2021): 2408. http://dx.doi.org/10.3390/microorganisms9112408.

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Anticancer treatment strategies using bacteria as a vector are currently expanding with the development of anticancer drugs. Here, we present a research strategy to develop anticancer drugs using bacteria that contain miRNAs. We also present a strategy for the development of novel bacterial anticancer drugs in combination with radiation. Salmonella strains expressing miRNA were produced by modifying the miRNA expression vector encoding INHA, a radiation-resistant gene developed previously. The anticancer effect of INHA was confirmed using skin cancer cell lines. We also tested a combination st

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Eity, Tanzila Akter, Md Shimul Bhuia, Raihan Chowdhury, et al. "Anticancer Efficacy of Decursin: A Comprehensive Review with Mechanistic Insights." Future Pharmacology 5, no. 2 (2025): 17. https://doi.org/10.3390/futurepharmacol5020017.

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Introduction: Decursin is a pyranocoumarin natural phytochemical found in the Angelica gigas Nakai herb, which shows various therapeutic properties and beneficial effects against various diseases. Objective: The aim of this study was to find the anticancer potential of decursin and its molecular mechanisms involved with different anticancer effects. Methodology: All of the relevant data concerning this compound and cancer were collected using different scientific search engines, including PubMed, Scopus, Springer Link, Wiley Online, Web of Science, Scifinder, ScienceDirect, and Google Scholar.

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Rachamalla, Hari Krishnareddy, Santanu Bhattacharya, Ajaz Ahmad, et al. "Enriched pharmacokinetic behavior and antitumor efficacy of thymoquinone by liposomal delivery." Nanomedicine 16, no. 8 (2021): 641–56. http://dx.doi.org/10.2217/nnm-2020-0470.

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Background: Thymoquinone (TQ) has potential anti-inflammatory, immunomodulatory and anticancer effects but its clinical use is limited by its low solubility, poor bioavailability and rapid clearance. Aim: To enhance systemic bioavailability and tumor-specific toxicity of TQ. Materials & methods: Cationic liposomal formulation of TQ (D1T) was prepared via ethanol injection method and their physicochemical properties, anticancer effects in orthotopic xenograft pancreatic tumor model and pharmacokinetic behavior of D1T relative to TQ were evaluated. Results: D1T showed prominent inhibition of

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Alven, Sibusiso, and Blessing Atim Aderibigbe. "Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs." Nanomaterials 10, no. 8 (2020): 1556. http://dx.doi.org/10.3390/nano10081556.

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Cancer remains a heavy health burden resulting in a high rate of mortality around the world. The presently used anticancer drugs suffer from several shortcomings, such as drug toxicity, poor biodegradability and bioavailability, and poor water solubility and drug resistance. Cancer is treated effectively by combination therapy whereby two or more anticancer drugs are employed. Most of the combination chemotherapies result in a synergistic effect and overcome drug resistance. Furthermore, the design of polymer-based nanocarriers for combination therapy has been reported by several researchers t

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Alanazi, Sitah, ZabnAllah M. Alaizeri, Rashid Lateef, Nawal Madkhali, Abdullah Alharbi, and Maqusood Ahamed. "Zn Doping Improves the Anticancer Efficacy of SnO2 Nanoparticles." Applied Sciences 13, no. 22 (2023): 12456. http://dx.doi.org/10.3390/app132212456.

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Tin dioxide (SnO2) nanoparticles (NPs) can be applied in several ways due to their low cost, high surface-to-volume ratio, facile synthesis, and chemical stability. There is limited research on the biomedical application of SnO2-based nanostructures. This study aimed to investigate the role of Zn doping in relation to the anticancer potential of SnO2 NPs and to enhance the anticancer potential of SnO2 NPs through Z doping. Pure SnO2 and Zn-doped SnO2 NPs (1% and 5%) were prepared using a modified sol–gel route. XRD, TEM, SEM, EDX, UV-Vis, FTIR, and PL techniques were used to characterize the p

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Bretin, Ludovic, Aline Pinon, Soukaina Bouramtane, et al. "Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer." Cancers 11, no. 10 (2019): 1474. http://dx.doi.org/10.3390/cancers11101474.

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Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nanoparticles are able to spontaneously accumulate in solid tumors through an enhanced permeability and retention (EPR) effect due to leaky vasculature, poor lymphatic drainage, and increased vessel permeability. Herein, we proved the added value of nanoparticle vectorization on anticancer efficacy and

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Meena, J., and K. S. Santhy. "ANTICANCER EFFICACY OF CYCLEA PELTATA ON HUMAN BREAST CARCINOMA CELLS." INDIAN DRUGS 54, no. 06 (2017): 53–57. http://dx.doi.org/10.53879/id.54.06.10783.

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Cancer has now been designated as a preventable disease with the increasing interest by the research community. The impartial administration of chemical treatments has now shifted to natural products due to the side effects observed with chemotherapy. In the present study, a pharmaceutical approach is undertaken to screen the anticancer potential of Cyclea peltata against breast cancer. We examined the in vitro anticancer potential of MCF-7 cancer cell lines by MTT assay using various concentrations of the methanol extract of the plant. In silico analysis were carried out by Schrodinger suite.

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You, Yuanyuan, Liye Yang, Lizhen He, and Tianfeng Chen. "Tailored mesoporous silica nanosystem with enhanced permeability of the blood–brain barrier to antagonize glioblastoma." Journal of Materials Chemistry B 4, no. 36 (2016): 5980–90. http://dx.doi.org/10.1039/c6tb01329e.

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Herein, a tailored MSNs nanosystem modified by an RGD peptide has been rationally designed, synthesized and used as a carrier of anticancer agents to enhance its BBB permeability and anticancer efficacy to treat human brain glioma.

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Ou, Yuan, Kai Chen, Hao Cai, et al. "Enzyme/pH-sensitive polyHPMA–DOX conjugate as a biocompatible and efficient anticancer agent." Biomaterials Science 6, no. 5 (2018): 1177–88. http://dx.doi.org/10.1039/c8bm00095f.

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An enzyme-responsive biodegradableN-(2-hydroxypropyl) methacrylamide (HPMA) polymer–DOX conjugate with high molecular weight has been prepared as a pH-sensitive anticancer agent, demonstrating excellent biosafety, high accumulation in tumors and significantly enhanced anticancer efficacy.

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Kah, Glory, Rahul Chandran, and Heidi Abrahamse. "Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy." Cells 12, no. 15 (2023): 2012. http://dx.doi.org/10.3390/cells12152012.

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Different conventional therapeutic procedures are utilized globally to manage cancer cases, yet the mortality rate in patients with cancer remains considerably high. Developments in the field of nanotechnology have included novel therapeutic strategies to deal with cancer. Biogenic (green) metallic silver nanoparticles (AgNPs) obtained using plant-mediated protocols are attractive to researchers exploring cancer treatment. Biogenic AgNPs present advantages, since they are cost-effective, easy to obtain, energy efficient, and less toxic compared to chemically and physically obtained AgNPs. Also

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D. N. Mehta, P. H. Patel, S. D. Mandal, and G. S. Chakraborthy. "In-silico APPROACH FOR VIRTUAL SCREENING AND MOLECULAR DOCKING OF FLAVONOIDS AS ERBB4 KINASE INHIBITORS IN THE TREATMENT OF CANCER." Rasayan J. Chem 17, no. 02 (2024): 605–10. http://dx.doi.org/10.31788/rjc.2023.1728769.

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The ongoing anticancer treatment is resulting in resistance to treatments, less efficacy, side effects, and other issues that need to be overcome by new anticancer drugs. Focusing on novel anticancer target ErbB4 kinase, responsible for tumor growth can be a promising approach against cancer. Naturally occurring plant-derived compounds are an important source of biologically active molecules with different chemical components having very little toxicity and high efficacy. This research highlights binding affinity, drug-like properties, bioactivity and toxicity prediction, and in-silico study o

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Conte, Claudia, Giovanni Dal Poggetto, Viola Schiano Di Cola, et al. "PEGylated cationic nanoassemblies based on triblock copolymers to combine siRNA therapeutics with anticancer drugs." Biomaterials Science 9, no. 18 (2021): 6251–65. http://dx.doi.org/10.1039/d1bm00909e.

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PEGylated cationic NPs based on PEG–pDMAEMA–PCL triblock copolymers are able to condense a therapeutic siRNA and simultaneously entrap the anticancer drug DTX, thus exerting in cancer cells high silencing efficacy and a combined anticancer effect.

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Kiełbowski, Kajetan, Paulina Plewa, Jan Zadworny, Estera Bakinowska, Rafał Becht, and Andrzej Pawlik. "Recent Advances in the Development and Efficacy of Anti-Cancer Vaccines—A Narrative Review." Vaccines 13, no. 3 (2025): 237. https://doi.org/10.3390/vaccines13030237.

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Immunotherapy is an established and efficient treatment strategy for a variety of malignancies. It aims to boost the anticancer properties of one’s own immune system. Several immunotherapeutic options are available, but immune checkpoint blockers represent the most widely known and investigated. Anticancer vaccines represent an evolving area of immunotherapy that stimulate antigen-presenting cells, cytotoxic responses of CD8+ T cells, and the presence of memory T cells, among others. Over the years, different approaches for anticancer vaccines have been studied, such as mRNA and DNA vaccines,

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Matsuno, Yusuke, Mai Hyodo, Haruka Fujimori, Atsuhiro Shimizu, and Ken-ichi Yoshioka. "Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules." Cancers 10, no. 10 (2018): 364. http://dx.doi.org/10.3390/cancers10100364.

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Radiation and certain anticancer drugs damage DNA, resulting in apoptosis induction in cancer cells. Currently, the major limitations on the efficacy of such therapies are development of resistance and adverse side effects. Sensitization is an important strategy for increasing therapeutic efficacy while minimizing adverse effects. In this manuscript, we review possible sensitization strategies for radiation and anticancer drugs that cause DNA damage, focusing especially on modulation of damage repair pathways and the associated reactions.

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Karabina, E. V., D. D. Sakaeva, and O. N. Lipatov. "Efficacy of Off-Label Use of Anticancer Drugs in Oncology." Creative surgery and oncology 13, no. 2 (2023): 151–58. http://dx.doi.org/10.24060/2076-3093-2023-13-2-151-158.

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The off-label use of anticancer drugs is widespread in modern oncology. The potential advantages of such prescriptions are associated with exceeding the expected clinical benefi ts over the risks of complications. The off-label use of anticancer drugs demonstrates the inconsistent efficacy of this approach depending on the type of malignancy, the reasons for prescribing these agents and their belonging to a particular pharmacological group. In a number of situations, the clinical benefits of off-label drugs are more convincing than in case of authorized indications. Currently, prescribing the

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Abdelmonem, M., S. E. Hammad, H. H. Elshikh, et al. "Anticancer Efficacy of Biosynthesized Zinc Oxide and Gold Nanoparticles." American Journal of Clinical Pathology 162, Supplement_1 (2024): S121. http://dx.doi.org/10.1093/ajcp/aqae129.269.

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Abstract Introduction/Objective Introduction: Advancements in nanoscale materials have led to the exploration of metal oxides for cancer diagnosis and therapy. Zinc oxide nanoparticles (ZnO NPs) and gold nanoparticles (Au NPs) are particularly promising due to their biocompatibility and anticancer properties demonstrated across various cancer cell lines. Objectives This study aimed to isolate fungal endophytes from Eucalyptus sideroxylon leaves and utilize them for the biosynthesis of nanoparticles (ZnO NPs and Au NPs) to assess their anticancer activity. Methods/Case Report Methods: Healthy E

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Wallace, H. M., and A. V. Fraser. "Polyamine analogues as anticancer drugs." Biochemical Society Transactions 31, no. 2 (2003): 393–96. http://dx.doi.org/10.1042/bst0310393.

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Just over 30 years ago, the late Diane Russell published the first in a series of papers linking polyamines and cancer. These early studies led to a flurry of research activity in the polyamine field that continues to this day attempting to identify a role for the polyamines in cancer development, treatment and/or prevention. The recognition that polyamines are critical for the growth of cancer cells, and consequently the identification of their metabolic pathways as a target for therapeutic intervention, led to the development of a number of useful inhibitors of polyamine biosynthesis. Arguab

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Chen, Qian, Jing Wu, Xiang Li, Ziyi Ye, Hailong Yang, and Lixian Mu. "Amphibian-Derived Natural Anticancer Peptides and Proteins: Mechanism of Action, Application Strategies, and Prospects." International Journal of Molecular Sciences 24, no. 18 (2023): 13985. http://dx.doi.org/10.3390/ijms241813985.

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Cancer is one of the major diseases that seriously threaten human life. Traditional anticancer therapies have achieved remarkable efficacy but have also some unavoidable side effects. Therefore, more and more research focuses on highly effective and less-toxic anticancer substances of natural origin. Amphibian skin is rich in active substances such as biogenic amines, alkaloids, alcohols, esters, peptides, and proteins, which play a role in various aspects such as anti-inflammatory, immunomodulatory, and anticancer functions, and are one of the critical sources of anticancer substances. Curren

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Kim, Ryungsa, Takanori Kin, and William T. Beck. "Impact of Complex Apoptotic Signaling Pathways on Cancer Cell Sensitivity to Therapy." Cancers 16, no. 5 (2024): 984. http://dx.doi.org/10.3390/cancers16050984.

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Anticancer drugs induce apoptotic and non-apoptotic cell death in various cancer types. The signaling pathways for anticancer drug-induced apoptotic cell death have been shown to differ between drug-sensitive and drug-resistant cells. In atypical multidrug-resistant leukemia cells, the c-Jun/activator protein 1 (AP-1)/p53 signaling pathway leading to apoptotic death is altered. Cancer cells treated with anticancer drugs undergo c-Jun/AP-1–mediated apoptotic death and are involved in c-Jun N-terminal kinase activation and growth arrest- and DNA damage-inducible gene 153 (Gadd153)/CCAAT/enhancer

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Kumar, Girish, Tarun Virmani, Ashwani Sharma, and Kamla Pathak. "Codelivery of Phytochemicals with Conventional Anticancer Drugs in Form of Nanocarriers." Pharmaceutics 15, no. 3 (2023): 889. http://dx.doi.org/10.3390/pharmaceutics15030889.

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Anticancer drugs in monotherapy are ineffective to treat various kinds of cancer due to the heterogeneous nature of cancer. Moreover, available anticancer drugs possessed various hurdles, such as drug resistance, insensitivity of cancer cells to drugs, adverse effects and patient inconveniences. Hence, plant-based phytochemicals could be a better substitute for conventional chemotherapy for treatment of cancer due to various properties: lesser adverse effects, action via multiple pathways, economical, etc. Various preclinical studies have demonstrated that a combination of phytochemicals with

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