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Thèses sur le sujet « Anticholesteremic agents »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 3 mars 2023

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1

Bursill, Christina. "Green tea and its catechins modulate cholesterol metabolism in cultured human liver (HepG2) cells and the hypercholesterolaemic rabbit." Title page, contents and introduction only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09pdb9725.pdf.

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Includes bibliographical references (21 leaves). Previous studies have found that green tea and its antitoxidant constituents, the catechins, are hypocholesterolaemic in both epidemiological and animal intervetion studies. The main objectives of the present study were to investigate the mechanism by which green tea and its most abundant catechin constituent epigallocatechin gallate increase the low-density lipoprotein (LDL) receptor of HepG2 cells. In addition, it was hoped to determine if a crude catechin extract from green tea could lower plasma cholesterol levels in the hypercholesterolaemi

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2

Chen, Jingnan. "Hypocholesterolemic activity of microalga schizochytrium sp." HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1417.

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3

藍志洪 and Chi-hung Nam. "Effect of cerivastatin on endothelial function in rat aorta." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B42575837.

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4

Nam, Chi-hung. "Effect of cerivastatin on endothelial function in rat aorta." Click to view the E-thesis via HKUTO, 2001. http://sunzi.lib.hku.hk/hkuto/record/B42575837.

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5

Marinangeli, Christopher P. F. "The composition, biological trafficking and cholesterol-lowering efficacy of sugarcane-derived policosanol supplements /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99351.

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The cholesterol-lowering efficacy of the original sugarcane-derived Cuban policosanol (OPC) supplement has been attributed to an exclusive policosanol purity and composition. The first objective of the following study was to compare the purity and composition of the OPC and alternative sugarcane derived policosanol (APC) products. Second, to measure blood lipids and policosanol levels in tissues, plasma and feces in hamsters receiving diet fortified with no policosanols, OPC, or an APC (APC1) product. Results indicated that the policosanol purity and composition of the OPC and APC formulations

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6

Xiu, Jin. "Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol-lowering drugs in Alzheimer's disease /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-758-8/.

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7

Eno, Megan. "The effect of the supplementation of cranberry seed oil on the lipid profiles of human subjects." Menomonie, WI : University of Wisconsin--Stout, 2007. http://www.uwstout.edu/lib/thesis/2007/2007enom.pdf.

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8

Chapman, Laurie. "In vitro hypocholesterolemic potential of dietary additives used by the Batemi and Maasai people : (Hypocholesterolemic potential of additives from a traditional diet)." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22725.

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Dietary phytochemicals such as saponins have been suggested to have therapeutic uses in the prevention and alleviation of hypercholesterolemia. Thus, twelve Tanzanian plant additives hypothesized to contain saponins and used in soup by the Batemi, were investigated for in vitro hypocholesterolemic potential by: (1) screening for likelihood of detectable saponins using TLC, hemolysis, frothing ability and molluscicidal activity. (2) using changes in hemolytic activity to indirectly examine interactions of plant extracts with cholesterol, cholesterol-analogues, conjugated bile salts and non-conj

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9

Tam, Hoi-ling. "Soluble receptors for advanced glycation end products in type 2 diabetes mellitus." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43572182.

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10

Boudreau, Denise M. "The association between HMG-CoA inhibitor use and breast cancer risk & a validation study of patient interview data and pharmacy records for antihypertensive, statin, and antidepressant medication use /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/7934.

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11

Varady, Kristina A. "Effect of plant sterol supplementation and endurance training on cardiovascular disease risk parameters and cholesterol kinetics in previously sedentary hypercholesterolemic adults." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111831.

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Background. A high ratio of total cholesterol to high-density lipoprotein (HDL) cholesterol, in addition to increased levels of small low-density lipoprotein (LDL) particles, are important indicators of cardiovascular disease risk. Therefore, interventions that combine the lowering of total cholesterol and raising of HDL cholesterol concentrations that also increase LDL particle size, may be preventive against cardiovascular disease. Plant sterols decrease total cholesterol and LDL cholesterol levels by 10-15%, while exercise increases HDL cholesterol levels by 4-22%. In view of their compleme

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12

Tam, Hoi-ling, and 譚凱鈴. "Soluble receptors for advanced glycation end products in type 2 diabetes mellitus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43572182.

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13

Lau, Vivian Wai Yan 1977. "Effects of plant sterols on plasma lipid profiles, glycemic control of hypercholesterolemic individuals with and without type 2 diabetes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80312.

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Plant sterols (PS) are effective in reducing plasma lipid concentrations, however, few studies have examined their cholesterol lowering effects in type 2 diabetics. The objective was to assess whether PS consumption alters blood lipid profile in hypercholesterolemic subjects with and without type 2 diabetes. Fifteen control subjects (age = 55.1 +/- 8.5 yr and BMI = 26.9 +/- 3.0kg/m2) and fourteen diabetic subjects (age = 54.5 +/- 6.7 yr and BMI = 30.2 +/- 3.0kg/m2) participated in a double-blinded, randomized, crossover, placebo-controlled feeding trial. The Western diet included either

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14

Journoud, Mélanie. "The effect of plant sterols on lipid profiles and cholesterol kinetics of hypercholesterolemic individuals with type 2 diabetes compared with non-diabetic controls /." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80296.

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The objective of this study was to compare the effect of phytosterols (PS) on lipid profiles and cholesterol kinetics of hypercholesterolemic individuals with or without type 2 diabetes. It was hypothesised that the response to PS would differ between both groups due to different lipid metabolism. During this randomised, double blind, crossover trial, participants consumed a controlled diet with placebo or PS for 21 days.<br>Plasma total cholesterol (TC) decreased with placebo and PS (10.9% and 9.7% in non-diabetic versus 11.6% and 13.6% in diabetic participants, p < 0.05). Plasma low-d

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15

Yoshida, Makiko. "Plant sterols and glucomannan as hypocholesterolemic and hypoglycemic agents in subjects with and without type 2 diabetes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80900.

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The objective of this research was to examine the effects of plant sterols and glucomannan on lipid profiles, plasma plant sterol levels and glycemic control in mildly hypercholesterolemic subjects. Thirteen type 2 diabetic and sixteen non-diabetic individuals participated in a randomized crossover trial consisting of 4 phases, of 21 days each. During the study period, subjects were supplemented with plant sterols and/or glucomannan. Overall reductions of total cholesterol and low-density lipoprotein (LDL) cholesterol concentrations were greater after consumption of plant sterols and gl

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16

Famer, Daniel. "Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-260-6/.

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17

Backlund, Lars. "General practitioners' decision-making on drug treatment of hypercholesterolaemia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-672-3/.

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18

Stenestrand, Ulf. "Improving outcome in acute myocardial infarction : the creation and utilisation of the Register of Information and Knowledge about Swedish Heart Intensive Care Admissions (RIKS-HIA) /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/med740s.pdf.

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19

Jonnalagadda, Satya Srivathsa. "The effect of different sources of dietary fiber on the plasma total and lipoprotein cholesterol, liver cholesterol, fecal neutral steroid excretion and histology of major organ tissues in hamsters." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/39709.

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The effect of diets with various dietary fiber sources on the plasma lipids, liver cholesterol, the histology of the gastrointestinal tract, heart, liver and kidney and the fecal neutral steroid excretion was investigated in hamsters. 155, 9-11 wk old, male Golden-syrian hamsters were fed a purified basal hypercholesterolemic diet (0.1% cholesterol, 10% fat, 4% dietary fiber) for 5 wk to elevate plasma lipid levels. Based on wk 4 plasma total cholesterol (TC) levels hamsters with elevated levels were randomly assigned, 16 animals/group, into six groups for another 4 wk: control, oat bran, guar

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20

Barake, Roula. "Effects of plant sterols and glucomannan on parameters of cholesterol kinetics in hyperlipidemic individuals with and without type 2 diabetes." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83964.

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The objective of this study was to examine the effects of plant sterols and/or glucomannan on lipid profiles and cholesterol kinetics in hyperlipidemic individuals with or without type 2 diabetes. It was hypothesized that plant sterols and glucomannan reduce circulating cholesterol levels and may have an additive or synergistic effect when combined by reducing cholesterol absorption. Thirteen type 2 diabetics and sixteen non-diabetics all mildly hypercholesterolemic free living subjects participated in a randomized crossover trial consisting of 4 phases, 21 days each. Subjects consumed

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21

Vilaplana, Saiz Marta. "Design and synthesis of new potentially inhibitors of PCSK9 and KRAS proteins." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673609.

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This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major cause of deaths in Spain and worldwide. The study of familial hypercholesterolemia is of great interest, as it is mainly caused by a protein called PCSK9 whose atypical functioning leads to an increase of LDL-C in blood. Thus, the study of new diseases results in the study of new therapeutic targets. Therefore, a thorough investigation on the PCSK9 protein has been conducted by means of molecular

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22

Strock, Cynthia Lynn. "The impact of electronic clinical reminders on medication trends and six-month survival after coronary artery bypass graft surgery in the Veterans Healthcare Administration /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Clinical Science) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 86-91). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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23

Murphy, Charlotte. "Studies on the regulatory roles of cholesterol and bile acids /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-173-9/.

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24

"Approaches towards the construction of statin analogues." 2011. http://library.cuhk.edu.hk/record=b5894840.

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Cheung, Chi Yun.<br>"September 2011."<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 57-59).<br>Abstracts in English and Chinese.<br>Acknowledgment --- p.i<br>Table of Contents --- p.ii<br>Abstract --- p.iii<br>Abstract (Chinese Version) --- p.iv<br>Abbreviation --- p.v<br>Chapter 1. --- Introduction --- p.1<br>Chapter 1.1 --- General Background --- p.1<br>Chapter 1.2 --- Mechanism of action --- p.3<br>Chapter 1.2.1 --- Biosynthetic pathway of cholesterol --- p.3<br>Chapter 1.2.2 --- Inhibition of HMG-CoA reductase by statins

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25

"The hypolipidemic effect of some lesser-known Chinese edible and medicinal mushrooms." 2003. http://library.cuhk.edu.hk/record=b5896096.

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Yeung Ming.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 136-162).<br>Abstracts in English and Chinese.<br>THESIS COMMITTEE --- p.i<br>ACKNOWLEDGEMENTS --- p.ii<br>ABSTRACT (ENGLISH) --- p.iii~v<br>ABSTRACT (CHINESE) --- p.vi~vii<br>TABLE OF CONTENTS --- p.viii~xiii<br>LIST OF TABLES --- p.xiv~xv<br>LIST OF FIGURES --- p.xvi~xviii<br>LIST OF ABBREVIATIONS --- p.xix~xx<br>Chapter CHAPTER ONE: --- INTRODUCTION --- p.1<br>Chapter 1.1 --- Different lipoproteins and their functions --- p.1<br>Chapter 1.1.1 --- Chylomicrons ---

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26

"In vitro and in vivo antioxidant activity and hypocholesterolemic effect in extracts of Agrocybe aegerita." 2005. http://library.cuhk.edu.hk/record=b5896402.

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Ng Yuk Fan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 145-162).<br>Abstracts in English and Chinese.<br>Thesis Committee: --- p.i<br>Acknowledgements --- p.ii<br>Abstract --- p.iii<br>摘要 --- p.v<br>Content --- p.vii<br>List of Tables --- p.xiii<br>List of Figures --- p.xvi<br>Abbreviations --- p.xviii<br>Chapter Chapter 1: --- Introduction --- p.1<br>Chapter 1.1 --- Antioxidants --- p.1<br>Chapter 1.1.1 --- Definition and mode of actions of antioxidants --- p.1<br>Chapter 1.1.2 --- Synthetic antioxidants --- p.2<br>Ch

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27

"Studies on the anti-tumor effects and action mechanisms of fluvastatin on murine myeloid leukemia cells." 2010. http://library.cuhk.edu.hk/record=b5894400.

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Chin, Chi Hou.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.<br>Includes bibliographical references (leaves [165]-178).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Abstract in Chinese (摘要） --- p.iv<br>Acknowledgements --- p.vi<br>Abbreviations --- p.vii<br>List of Figures and Tables --- p.xi<br>Publications --- p.xv<br>Chapter Chapter 1 --- General Introduction<br>Chapter 1.1. --- Hematopoiesis and Leukemia --- p.2<br>Chapter 1.1.1. --- Hematopoiesis --- p.2<br>Chapter 1.1.2. --- Leukemia --- p.8<br>Chapter 1.1.2.1. --- Overview of leukemia --- p.8<br>Ch

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28

Bursill, Christina Anne. "Green tea and its catechins modulate cholesterol metabolism in cultured human liver (HepG2) cells and the hypercholesterolaemic rabbit / Christina Anne Bursill." Thesis, 2000. http://hdl.handle.net/2440/22484.

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Includes bibliographical references (21 leaves).<br>1 v. (various pagings) : ill. ; 30 cm.<br>Previous studies have found that green tea and its antitoxidant constituents, the catechins, are hypocholesterolaemic in both epidemiological and animal intervetion studies. The main objectives of the present study were to investigate the mechanism by which green tea and its most abundant catechin constituent epigallocatechin gallate increase the low-density lipoprotein (LDL) receptor of HepG2 cells. In addition, it was hoped to determine if a crude catechin extract from green tea could lower plasma c

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29

"Mechanism of the hypocholesterolemic effect of water-soluble non-starch polysaccharides from jelly mushroom." 2006. http://library.cuhk.edu.hk/record=b5892916.

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Lam Wai Yee.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (leaves 124-148).<br>Abstracts in English and Chinese.<br>Chapter Chapter 1: --- Introduction --- p.1<br>Chapter 1.1 --- Lipoproteins --- p.1<br>Chapter 1.1.1 --- General structure --- p.1<br>Chapter 1.1.2 --- Chylomicrons --- p.2<br>Chapter 1.1.3 --- Very-low-density lipoprotein (VLDL) --- p.3<br>Chapter 1.1.4 --- Low-density lipoprotein (LDL) --- p.4<br>Chapter 1.1.5 --- High-density lipoprotein (HDL) --- p.4<br>Chapter 1.1.6 --- Lipoprotein metabolism --- p.5<br>Chapter 1.

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30

"Pharmacogenetic and environmental determinants of response to HMG-CoA reductase inhibitors." Thesis, 2007. http://library.cuhk.edu.hk/record=b6074340.

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A total of 146 Chinese patients with various degrees of hyperlipidaemia and high cardiovascular risk, suitable for treatment with rosuvastatin 10 mg daily and in whom it was possible to obtain baseline lipid profiles measured on no lipid lowering drug, were enrolled in to the study. The drug compliance was assessed by personal interview and 9 patients were excluded from the efficacy analysis because they stated their compliance was less than 80%. From the remaining 137 subjects, 62 had a clinical diagnosis of familial hypercholesterolaemia. Data for dietary intake were available in 121 of the

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31

Han, Xu. "Identification and mechanistic investigation of clinically important myopathic drug-drug interactions." Thesis, 2014. http://hdl.handle.net/1805/5275.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Drug-drug interactions (DDIs) refer to situations where one drug affects the pharmacokinetics or pharmacodynamics of another. DDIs represent a major cause of morbidity and mortality. A common adverse drug reaction (ADR) that can result from, or be exacerbated by DDIs is drug-induced myopathy. Identifying DDIs and understanding their underlying mechanisms is key to the prevention of undesirable effects of DDIs and to efforts to optimize therapeutic outcomes. This dissertation is dedicated to identification of clinically important myop

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32

Hajati, Farshid. "Analysis of health trajectories using administrative data." Thesis, 2020. http://hdl.handle.net/1959.7/uws:56235.

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This thesis presents studies of health trajectories using administrative data. In the first study, we propose a new method for clustering of Medicare Benefit Schedule (MBS) claim trajectories. In the second study, we examine the extent to which the adult Australian population on lipid-lowering medications receives the level of High-Density Lipoprotein-Cholesterol (HDL-C) testing recommended by national guidelines. Finally, we study mental health services and medications usage in the MBS and Pharmaceutical Benefit Scheme (PBS) administrative data for the purpose of finding groups of patients wi

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