Littérature scientifique sur le sujet « Antimalarial drug efficacy »

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Articles de revues sur le sujet "Antimalarial drug efficacy"

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Ringwald, P. "Monitoring Antimalarial Drug Efficacy." Clinical Infectious Diseases 38, no. 8 (2004): 1192–93. http://dx.doi.org/10.1086/383152.

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Sá, Juliana M., Jason L. Chong, and Thomas E. Wellems. "Malaria drug resistance: new observations and developments." Essays in Biochemistry 51 (October 24, 2011): 137–60. http://dx.doi.org/10.1042/bse0510137.

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Drug-resistant micro-organisms became widespread in the 20th Century, often with devastating consequences, in response to widespread use of natural and synthetic drugs against infectious diseases. Antimalarial resistance provides one of the earliest examples, following the introduction of new medicines that filled important needs for prophylaxis and treatment around the globe. In the present chapter, we offer a brief synopsis of major antimalarial developments from two natural remedies, the qinghaosu and cinchona bark infusions, and of synthetic drugs inspired by the active components of these
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Tang, Yu-Qing, Qian Ye, He Huang, and Wei-Yi Zheng. "An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance." Current Molecular Medicine 20, no. 8 (2020): 583–92. http://dx.doi.org/10.2174/1566524020666200207123253.

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: Malaria is one of the three most deadly infectious diseases in the world and seriously endangers human health and life. To reduce the public health burden of this disease, scientists have focused on the discovery and development of effective antimalarial drugs, from quinine and chloroquine to antifolates and artemisinin and its derivatives, which all play a profound role in the treatment of malaria. However, drugresistant strains of Plasmodium falciparum have emerged due to frequent use of antimalarials and have become increasingly resistant to existing antimalarial drugs, causing disastrous
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White, Nicholas J. "The assessment of antimalarial drug efficacy." Trends in Parasitology 18, no. 10 (2002): 458–64. http://dx.doi.org/10.1016/s1471-4922(02)02373-5.

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Ujuamala Uloma Ezeani, Penaere Theresa Osahon, and Michael Chukwudi Ezeani. "Pattern of anti-malarial drugs and artemether combination therapy adherence in an institution based medical centre, Nigeria." World Journal of Advanced Research and Reviews 8, no. 3 (2020): 162–70. http://dx.doi.org/10.30574/wjarr.2020.8.3.0437.

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The change in policy guidelines for treating uncomplicated malaria became necessary because the therapeutic efficacy of chloroquine and SP had deteriorated. Hence compliance is a necessity to enable effective check on malaria. This work was carried out to evaluate antimalaria drug prescription and to update its usage in line with WHO guideline on Artemeter Combination therapy in a university based medical center. We utilized descriptive, cross-sectional, retrospective study of antimalaria prescriptions purposely carried out among male and female outpatients with mean age of 22.4±2.8 at a Unive
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MWANGI, JONATHAN M., and LISA C. RANFORD-CARTWRIGHT. "Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance." Parasitology 140, no. 12 (2013): 1455–67. http://dx.doi.org/10.1017/s0031182013000954.

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SUMMARYThe biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists inPlasmodium falciparumwhich causes the most suffering among all human malaria parasites. Monitoring of antimalarial efficacy and the development and subsequent spread of resistance has become an important part in the treatment and control of malaria. With recent reports of reduced efficacy of artemisinin, the current recommended treatment for uncomplicated malaria, there is urgent need for better methods to recogni
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Bennett, Tyler N., Michelle Paguio, Bojana Gligorijevic, et al. "Novel, Rapid, and Inexpensive Cell-Based Quantification of Antimalarial Drug Efficacy." Antimicrobial Agents and Chemotherapy 48, no. 5 (2004): 1807–10. http://dx.doi.org/10.1128/aac.48.5.1807-1810.2004.

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ABSTRACT We report on the development of a new SYBR Green I-based plate assay for analyzing the activities of antimalarial drugs against intraerythrocytic Plasmodium falciparum. This assay is considerably faster, less labor-intensive, and less expensive than conventional radiotracer (e.g., [3H]hypoxanthine and [3H]ethanolamine)-based assays or P. falciparum lactate dehydrogenase activity-based assays. The assay significantly improves the pace at which antimalarial drug discovery efforts may proceed.
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Sunitha G N, Satyavati Dulipala D, and Girish Gudi. "Evaluation of metabolic stability of antimalarial and antiretroviral drugs." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (2019): 2591–601. http://dx.doi.org/10.26452/ijrps.v10i3.1515.

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The concomitant administration of drugs and antimalarial drugs is recommended for the treatment of HIV (Human Immunodeficiency Virus) patients with malaria resulting in drug-drug interactions (DDI) causing either lack of efficacy or toxicities. Drug metabolism is often the first step in understanding the DDI potential of either a new chemical entity or a combination of drugs. inhibitor (PI) such as is a potent CYP 3A4 inhibitor and may interact with these antimalarial drugs that are metabolized by CYP3A4 to cause metabolism-related DDI's. the present study is an attempt to evaluate the potenti
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Dow, G. S., T. N. Heady, A. K. Bhattacharjee, et al. "Utility of Alkylaminoquinolinyl Methanols as New Antimalarial Drugs." Antimicrobial Agents and Chemotherapy 50, no. 12 (2006): 4132–43. http://dx.doi.org/10.1128/aac.00631-06.

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ABSTRACT Mefloquine has been one of the more valuable antimalarial drugs but has never reached its full clinical potential due to concerns about its neurologic side effects, its greater expense than that of other antimalarials, and the emergence of resistance. The commercial development of mefloquine superseded that of another quinolinyl methanol, WR030090, which was used as an experimental antimalarial drug by the U.S. Army in the 1970s. We evaluated a series of related 2-phenyl-substituted alkylaminoquinolinyl methanols (AAQMs) for their potential as mefloquine replacement drugs based on a s
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Fidock, David A., Philip J. Rosenthal, Simon L. Croft, Reto Brun, and Solomon Nwaka. "Antimalarial drug discovery: efficacy models for compound screening." Nature Reviews Drug Discovery 3, no. 6 (2004): 509–20. http://dx.doi.org/10.1038/nrd1416.

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Thèses sur le sujet "Antimalarial drug efficacy"

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Van, Huyssteen Este. "Efficacy enhancement of the antimalarial drugs, mefloquine and artesunate, with PheroidTM technology / E. van Huyssteen." Thesis, North-West University, 2010. http://hdl.handle.net/10394/5050.

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Malaria is currently one of the most imperative parasitic diseases in developing countries. Artesunate has a short half-life, low aqueous solubility and resultant poor and erratic absorption upon oral administration, which translate to low bioavailability. Mefloquine is eliminated slowly with a terminal elimination half-life of approximately 20 days and has neuropsychiatric side effects. Novel drug delivery systems have been utilised to optimise chemotherapy with currently available antimalarial drugs. Pheroid™ technology is a patented drug delivery system which has the ability to capture, tra
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SOE, AUNG PAING. "Treatment efficacy of artesunate-amodiaquine and prevalence of Plasmodium falciparum drug resistance markers in Zanzibar, 2002-2017." Thesis, Uppsala universitet, Internationell mödra- och barnhälsovård (IMCH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373268.

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Introduction: Emergence of resistance to artemisinin-based combination therapy (ACT) is a major threat to combat Plasmodium falciparum malaria. Regular therapeutic studies to monitor treatment efficacy is essential, and genotyping of molecular makers is useful for mapping development and spread of resistance. Aims: The study aims are to assess efficacy of artesunate-amodiquine (ASAQ) and prevalence of molecular markers of drug resistance in Zanzibar in 2017. Methods: Treatment efficacy of the clinical trial conducted in 2017 was compared with efficacies in 2002 and 2005. A total of 142 samples
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Matlebjane, Dikeledi M. A. "In vitro efficacy assessment of targeted antimalarial drugs synthesized following in silico design." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/63045.

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Malaria is a major public health problem that affects millions of lives globally. The increased burden of malaria requires new interventions that will address the eradication of the disease. Current interventions include vector control by using insecticide-treated bed nets and indoor residual spraying, and antimalarial drugs to control the parasite. Parasite resistance has been reported for the currently used effective antimalarial drugs. To pre-empt the impact of parasite resistance a continued development of new antimalarial drugs that have novel mechanisms of action should be pursued.
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Yohannes, Ambachew Medhin. "Malaria treatment in Ethiopia: antimalarian drug efficacy monitoring system and use of evidence for policy." Thesis, 2013. http://hdl.handle.net/10500/8668.

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The purpose of this study was to describe the characteristics and findings of antimalarial drug efficacy studies conducted in Ethiopia and to use the findings to formulate recommendations for antimalarial drug efficacy monitoring and use of evidence to inform antimalarial treatment policy for the Ethiopian setting. This study reviewed 44 antimalarial efficacy studies conducted in Ethiopia from 1974 to 2011. The analysis of results indicated that chloroquine as the first-line antimalarial drug for the treatment of malaria due to Plasmodium falciparum had a 22% therapeutic failure in 1985
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Livres sur le sujet "Antimalarial drug efficacy"

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Csizmadia, Emanuel. Antimalarial drugs: Costs, safety and efficacy. Nova Biomedical Books, 2009.

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Emanuel, Csizmadia, and Kalnoky Istvan, eds. Antimalarial drugs: Costs, safety, and efficacy. Nova Science, 2009.

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Chapitres de livres sur le sujet "Antimalarial drug efficacy"

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Imrat, Ajeet Kumar Verma, and Pooja Rani Mina. "Recent Advances in Antimalarial Drug Discovery: Challenges and Opportunities." In Plasmodium Species and Drug Resistance [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97401.

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Malaria is a global health problem that needs attention from drug discovery scientists to investigate novel compounds with high drug efficacy, safety and low cost to encounter the malaria parasites that are resistant to existing drug molecules. Antimalarial drug development follows several approaches, ranging from modifications of existing agents to the design of novel agents that act against novel targets. Most of market and clinical drugs act on blood schizonticide are in current therapy for malaria reduction. This chapter will intend to highlight the currently available drugs including various novel agents. In addition, emphasis has been given on the prospective pharmacophores that are likely to emerge as effective clinical candidates in the treatment of malaria. Besides all aspects, some alternative approaches will also be highlight.
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Ahmed, Toqeer, Irfan Liaqat, and Muhammad Zeeshan Hyder. "Nanotechnology Based Emerging Approaches to Combat Malaria and Dengue Fever." In Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-5049-6.ch008.

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Nanotechnology has vast applications in virtually all the fields including health and environment. Nanomaterials have different origins like plants, animals, metals, and microorganisms. They have larvicidal activities against mosquito larvae that cause malaria and dengue fever which are most malicious parasitic diseases of human beings. Multidrug resistance of malaria has been reported in different parts of Southeast Asia especially to the first line of antimalarial drugs. Nanomaterials having different origin, sizes, concentrations, and shapes, have varied efficacy against the vectors which are comparable with the commercially available insecticides and even have better results than the same. Nanomaterials can be used as an alternative to commercially available insecticides for the eradication of vectors causing both the diseases. In this chapter, types, sources, composition, larvicidal potential against vectors of nanomaterials have been discussed along with possible toxicity and future recommendations on the eco-friendly approach for the control of mosquito-borne diseases.
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