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Voloboy, N. L., Ya F. Zverev, V. M. Bryukhanov, et al. "Antioxydant and prooxydant effects of arbutin and hydrohinon in experiment in vitro." Bulletin of Siberian Medicine 10, no. 5 (2011): 41–44. http://dx.doi.org/10.20538/1682-0363-2011-5-41-44.
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The object of research is to compare antioxidant and prooxydant activity of arbutin and hydrochinon in vitro. Antioxidant and prooxydant activity of arbutin and hydrochinon is estimed of their ability to suppress/ induct oxydation ТВИН-80. Arbutin and hydrochinon have antioxydant and prooxydant properties. The conclusions are, that hydrochinon is more antioxydant, arbutin is more prooxydant.
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Noumedem, Jaurès A. K., Doriane E. Djeussi, Gerald Ngo Teke, Jean D. Tamokou, and Jules R. Kuiate. "Antibacterial, antioxydant and antidiarrheal properties of Tristemma hirtum P. beauv." Investigational Medicinal Chemistry and Pharmacology 3, no. 1 (2020): 1–7. http://dx.doi.org/10.31183/imcp.2020.00040.
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Boisfer, E., D. Stengel, D. Pastier, et al. "Human apolipoprotein A-II expression in mice decreases antioxydant properties of HDL." Atherosclerosis Supplements 2, no. 2 (2001): 72. http://dx.doi.org/10.1016/s1567-5688(01)80155-0.
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ALLAOUI, Amine, Khadidja ZOUD, Moncef NASRI, and Ahmed BOUALGA. "Antioxidant properties of ultrafiltration membrane fractions obtained from fenugreek (Trigonella foenum-graecum) proteins hydrolysates." Nutrition & Santé 07, no. 02 (2019): 78–85. http://dx.doi.org/10.30952/ns.7.2.5.
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Mamangkey, Jendri, Dwi Suryanto, Erman Munir, and Apon Zaenal Mustopa. "Antibacterial and Antioxidant Activity of Newly Keratinolytic Bacteria, Azotobacter chroococcum B4." International Journal of PharmTech Research 13, no. 2 (2020): 123–27. http://dx.doi.org/10.20902/ijptr.2019.130215.
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Keratinolyticbacteria of A. chrocoocum B4 was evaluated for its potential of antibacterial and antioxidant activity. Kirby-Bauer method was used to know antibacterial potential of B4 againtsStaphylococcus aureus, S. epidermidis, Bacillus cereus, Bacillus pumilus, Bacillus subtilis, Listeria monocytogenes, Proteus sp., enteropathogenicEscherichia coli, Enterobactersakazakii, and Salmonella enterica. Antioxydant test was done using DPPH radical scavenging activity assay with ascorbic acid as a controll. In this study, hydrolysate of pellet, dialysis, and fraction 25 of B4 keratinase purification of previous study was used for antibacterial and antioxidant test. The result showed that B4 hydrolysatesinhibited Gram positive pathogenic bacteria such as Staphylococcus aureus and Listeria monocytogenes, and Gram negative Enterobacter sakazakii. All hydrolysates showed to have antioxidant properties in which fraction 25 showed higher compared to that of others. This study showed poultry waste-derived keratinase of B4 might be useful as supplementary protein, antibacterial, and antioxidant in the animal feed formulations.
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Pozdnyakov DI, Pozdnyakov, Voronkov Voronkov AV, Zolotych Zolotych DS, and Arlt Arlt AV. "Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia." Journal of Young Pharmacists 10, no. 2 (2018): 193–96. http://dx.doi.org/10.5530/jyp.2018.10.43.
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Nana, Olga, Jean Momeni, Fabrice Fekam Boyom, and Martin Benoît Ngassoum. "Influence of microwave assisted extraction on antioxidant and antiplasmodial activities of Trichilia roka extracts." Journal of Phytopharmacology 4, no. 5 (2015): 248–52. http://dx.doi.org/10.31254/phyto.2015.4502.
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Antiplasmodial and antioxidant activities of extracts derived from Trichilia roka (Chiov) (Meliaceae) root bark were determined respectively in vitro and using two methods as well as 1,1-diphenyl-2-picrylhydrazyl radicalscavenging and β-carotene-linoleate model systems. The microwave assisted extraction extract was more effective concern antioxydant activity than the antiplasmodial activity compare to conventional mechanical agitation extraction method. Extracts obtained by microwave assisted extraction showed a high total polyphenol content of 126766 μg Equivalent of Gallic acid /g Dry Mater and a total flavonoid content of 789.22 μg Equivalent of Quercetin/g dry mater but a low antiplasmodial activity with and inhibition concentration of 48.386 μg /mL and 23.983 μg/mL for mechanical agitation extract. The evaluation of the antioxidant properties of the two extracts showed that those obtained by microwave assisted extraction shown in the 1,1-diphenyl-2-picrylhydrazyl assay and in the β-carotene bleaching test, the highest antioxidant activity respectively, with an antioxidant activity of 82.12% and with a radical-scavenging activity with inhibition percentage of 88.78%..
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Comlekcioglu, Nazan, Rıdvan Cirak, Akide Karmis, and Ashabil Aygan. "Evaluation of the chemical composition and biological activities of medicinal plants Alkanna tinctoria and Teucrium polium from Turkey." Croatian journal of food science and technology 14, no. 1 (2022): 52–62. http://dx.doi.org/10.17508/cjfst.2022.14.1.06.
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Since ancient times, natural products from various plants have been used for the treatment of different diseases. Alkanna and Teucrium species have been considered medicinal plants and are used popularly around the world. So, investigating the pharmaceutical properties of these plants has been the subject of interest for many researchers. In this work, total phenolic and flavonoid content, antioxydant, antimicrobial activity and in vitro enzyme inhibition properties of Alkanna tinctoria and Teucrium polium ethanol and methanol extracts were investigated. Additionally, GC-MS analyses of oil composition of the plant extracts were performed and 21 different fatty acids were identified in A. tinctoria and 18 in T. polium. Palmitic acid was the major component in A. tinctoria and saturated fatty acids constitutes a large part of the oil composistion. On the other hand, linoleic acid was the major fatty acid in T. polium and unsaturated fatty acids constitutes a large part of the oil composition. According to the results, methanol was more effective than the ethanol for the extraction of bioactive components. Both of the extracts showed a good antioxidant activity and the inhibition of bacteria and yeasts. Slight inhibitory activity of A. tinctoria and protective action of T. polium on enzyme with other results indicate that these plant extracts have potential to control microorganisms which can be promising for food industry.
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Weyepe Lah, Fidèle Castro, Marius Balemaken Missi, Natasha October, et al. "Antibacterial and Antioxidant Activities of the Extract and Some Flavonoids From Aerial Parts of Echinops Gracilis O. Hoffm. (Asteraceae)." Natural Product Communications 16, no. 3 (2021): 1934578X2199915. http://dx.doi.org/10.1177/1934578x21999151.
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Mortality due to microbial diseases continues to be a major problem in many developing countries. The present study aims to evaluate the antibacterial and antioxidant activities of the ethyl acetate extract and some isolated compounds from aerial parts of Echinops gracilis. The phytochemical study resulted in the isolation of a new flavonoid derivative named apigenin-7- O-(4″-feruloyl)-β-D-glucoside (1), together with 2 known compounds: apigenin -7-O-(4″-trans- p-hydroxycinnamoyl) -β-D-glucoside (2), and apigenin -7-O-glucoside (3). Their chemical structures were determined using a combination of NMR and IR spectroscopic and MS techniques, as well as by comparison with literature data. The extract and isolates were evaluated for their antibacterial and antioxydant properties. The EtOAc extract and compounds 1 and 2 showed the ability to scavenge 2,2′-zino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS) with scavenging concentration (SC50) values of 13.6 ± 0.8 µg/mL, 108.2 ± 4.3 µg/mL, and 28.5 ± 2.2 µg/mL, respectively. In addition, compound 1 displayed significant activity against Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia, with minimum inhibition concentration (MIC) values of 31.2, 15.6, and 31.2 µg/mL respectively.
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Pincemail, Joël, Mouna-Messaouda Kaci, Claire Kevers, Jessica Tabart, Raymond Ebabe Elle, and Smail Meziane. "PAOT-Liquid® Technology: An Easy Electrochemical Method for Evaluating Antioxidant Capacity of Wines." Diseases 7, no. 1 (2019): 10. http://dx.doi.org/10.3390/diseases7010010.
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Polyphenol compounds present in high quantity in wines are well-known to have potent cardio-protective properties through several biological mechanisms including antioxidant activity [1]. A large number of methods have been developed for evaluating the antioxidant capacity of food matrices. Most of them have, however, the disadvantage of being time consuming and require specific analytical protocols and devices. In the present study, we present the electrochemical PAOT (Pouvoir Antioxydant Total)-Liquid® Technology which can be easily used by winemakers for evaluating antioxidant activity of wine during all steps of making process. The methodology is based on the measurement of electric potential variation resulting from chemical reactions between wine polyphenols and a free radical mediator M• as source of oxidants. Total antioxidant activity as estimated by the PAOT-Liquid® activity was 6.8 fold higher in red wines (n = 14) when compared to rosé (n = 3) and white (n = 3) wines bought in a commercial market. Moreover, PAOT-Liquid® activity was highly correlated with total polyphenols content (TPC) of all wines (r = 0.9540, p < 0.0001) and the classical DPPH (2,2-diphenyl-1-picryhydrazyl) assay which is often used for evaluating antioxidant capacity of food matrices (r = 0.9102, p < 0.0001).
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LAOUFI, Razika, Khaled BOUDJEMA, Samia LEFKIR, Narimen BENHABYLES, Ouahiba BOUCHENAK, and Karima YAHIAOUI. "Valorization and biological effect of Zizuphus jujuba Mill. vegetable oil." Nutrition & Santé 12, no. 01 (2023): 38–47. http://dx.doi.org/10.30952/ns.12.1.5.
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Abstract Introduction. The natural plant resources are products with high added value, used in various fields for the manufacture of a wide variety of products. Objective. The purpose of this study was the physicochemical and chromatographic characterization of Ziziphus jujuba seeds vegetable oil, and the evaluation of their antioxidant and anti-inflammatory activity. Material and methods. Seeds oil extraction was done by soxhlet. Fatty acid content was determined by gas chromatography (GPC). Organoleptic and physicochemical characteristics were determined, and antioxidant activity was evalua-ted by diphenyl-picryl-hydrazyl (DPPH) test and -carotene bleaching. Anti-inflam-matory activity was essayed using carrageenan-induced plantar edema model in mice. Results. Extracted seeds oil had an extraction yield of 3.4%. GPC characterization sho-wed the presence of 12 fatty acids with a predominance of oleic acid (47.02%), and linoleic acid (37.40%). Physicochemical parameters of Ziziphus jujuba seeds oil showed an acidity of 2.05%, a saponification value of 198.17 mg KOH/mL, and refractive index of 1.471±0.00. This oil expressed a significant antiradical activity for the DPPH test, and low for that of β-carotene. In vivo study of edema induction in mice showed that oil had a maximum effective effect in inhibiting oedema (55.89±0.03%), at the first hour, compared to Diclofenac (19.88±0.12%), at the same hour. Conclusion. These results highlight the fatty acids richness of Ziziphus jujuba seeds oil with antioxidant and anti-inflammatory effects. These properties make it possible to predict its use in biotech-nology and cosmetology. [Introduction. Les ressources naturelles végétales sont des produits à forte valeur ajoutée, utilisés dans divers domaines pour la fabrication d’une large variété de produits. Objectif. Le présent travail a pour but la caractérisation physico-chimique et chromatographique de l’huile végétale des graines de Ziziphus jujuba Mill., et l’évaluation de leur activité antioxydante et anti-inflammatoire. Matériel et méthodes. L’huile des graines extraite par soxhlet est caractérisée sur le plan organoleptique et physicochimique. La teneur en acides gras est déterminée par une analyse chromato-graphique en phase gazeuse (CPG). L’activité antioxydante est évaluée par le test diphe-nyl-picryl-hydrazyl (DPPH) et le test de blanchiment. L’activité anti-inflammatoire est déterminée à l’aide du modèle de l’œdème plantaire induit chez la souris par la carra-génine. Résultats. L’huile présente un rendement d’extraction de 3,14%. La caracté-risation par la CPG montre la présence de 12 acides gras avec une prédominance de l’acide oléique (47,02%) et l’acide linoléique (37,40%). Les paramètres physico-chimi-ques ont montré une acidité de 2,05%, un indice de saponification de 198,17mg KOH/mL, un indice de réfraction de 1,471±0,00. L’huile végétale testée exprime une activité anti-radicalaire importante pour le test de DPPH et forte pour celui de β-carotène. L’induction d’œdème chez les souris a montré un effet efficace maximal de l’huile dans l’inhibition de l’œdème à la première heure, par rapport au Diclofénac à la même heure. Conclusion. Les résultats de cette étude font ressortir la richesse de l’huile des graines de Ziziphus jujuba en acides gras dotés d’un effet antioxydant et anti-inflammatoire. Ces propriétés permettent de prévoir son utilisation en biotechnologie et en cosmétologie.]
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Saragih S., Franscixkus Jamadin, I. Ketut Suter, and Ni Luh Ari Yusasrini. "ktivitas Antioksidan Dan Sifat Sensoris Teh Herbal Celup Kulit Anggur (Vitis vinifera L.) Pada Suhu Dan Waktu Pengeringan." Jurnal Ilmu dan Teknologi Pangan (ITEPA) 10, no. 3 (2021): 424. http://dx.doi.org/10.24843/itepa.2021.v10.i03.p10.
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 The research aimed to determine the effect of drying temperature and time on antioxidant activity and sensory properties of herbal tea bag of grape skin and to obtain the best of temperature and drying time that can produce grape skin herbal tea bag with highest antioxidant activity and the best sensory properties.This research used a completely randomized design with factorial pattern in two factors namely, drying temperature (50oC, 60oC, 70oC) and drying time (3.0 hours, 3.5 hours, 4.0 hours). There are 9 treatment combinatioms, each treatment combination was repeated 2 times so that it obtained 18 experimental units. Parameters observed were water content, total phenols, total falvonoids, antiokxidant activity, total anthocyanin, and sensory properties. The data obtained were analyzed by analysis of variance. If the treatment had a significant effect, it would be followed by the Duncan Multiple Range Test. The results showed that interaction beetwen drying temperature and time treatment had a significant (P<0.01) on antioxidant activity, total phenols, total falvonoids, total anthocyanin, extract content in water, water content, and color (scoring test), but no significant (P>0.05) on the color (hedonic test), aroma (hedonic test), taste (hedonic test), and overall acceptance. The results showed a drying temperature of 60oC with a drying time of 3.0 hour was the optimum drying temperature and time to produce herbal tea bag of grape skin with antioxydant activity of (IC50 1512.17 ppm), water content of 5.60%, total phenol content 9.21 mg GAE/g, total flavonoids content of 6.15 mg QE/g, total anthocyanin content 8.39 mg/g, extract content 41.85%, dark purple color with hedonic color, taste, aroma and overall acceptance is neither like nor dislike.
 
 
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Iermolenko, T. I., O. M. Shapoval, and A. V. Krivoshapkа. "ACTIVITY OF ANTIOXIDANT PROTECTION ENZYMES IN BLOOD AS A MARKER OF NEPHROPROTECTIVE EFFECT BY SODIUM POLY-(2,5-DIHYDROXYPHENYLEN)-4-THIOSULFATE ACID." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 1 (2020): 18–22. http://dx.doi.org/10.31718/2077-1096.20.1.18.
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The article presents the results of assessing the activity of catalase and superoxide dismutase enzymes in the blood as markers of the nephroprotective effect by sodium poly-(2,5-dihydroxyphenylen)-4-thiosulfate acid under conditions of ethylene glycol and glycerol acute kidney injury and gentamicin-induced nephropathy. The studies were conducted on 96 white mature, full-grown non-linear rats of both sexes weighting 180-200 grams. Models of acute kidney pathology in the rats were reproduced in accordance with the methodological recommendations of the Ministry of Health of Ukraine. Blood activity of superoxide dismutase and catalase was determined spectrophotometrically with standard methods. It has been established that oxidative stress plays a significant role in the pathogenesis of ethylene glycol and glycerol acute kidney damage and gentamicin nephropathy, as evidenced by significant changes in the antioxidant defence system, and namely by inhibition of the activity of superoxide dismutase and catalase enzymes. Under the conditions of acute kidney injury and nephropathy, the sodium poly-(2,5-dihydroxyphenylen)-4-thiosulfate acid contributed to the activation of superoxide dismutase and catalase better than reference medicines as plan-based chophytol, and mexidol as antihypoxant and thiotriazoline as antioxydant. Thus, the antioxidant enzymes as superoxide dismutase and catalase can serve as markers of the nephroprotective effect produced by the preparation of sodium poly-(2,5-dihydroxyphenylen)-4-thiosulfate acid. And therefore, we suggest sodium poly-(2,5-dihydroxyphenylen)-4-thiosulfate acid exhibiting antihypoxic, cytoprotective, antioxidant properties is a promising drug for the treatment of acute kidney diseases.
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Zerkani, H., I. Tagnaout, Z. Khiya, et al. "Comparative Study of the Antioxidant Power of Polyphenols of Leaves, Fruits, and Bark of Pistacia atlantica Desf. from Morocco." Journal of Chemistry 2022 (May 20, 2022): 1–13. http://dx.doi.org/10.1155/2022/7432169.
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Pistacia atlantica Desf. is a widely used plant species in the traditional medicine for its various pharmacological properties. The aim of this study is the valorisation of polyphenols and the antioxidant power of three organs from Pistacia atlantica Desf. (leaves, fruits, and bark). Phytochemical screening of secondary metabolites was performed using precipitation and coloring reactions. Total phenols, flavonoids, and condensed tannins were quantified, respectively, by the Folin-Ciocalteu method, the aluminum trichloride method, and the vanillin method. Evaluation of the antioxidant activity was made using two methods: DPPH ∗ (2,2 ′ -diphenyl-1-picryl hydrazyl) and FRAP (ferric reducing antioxidant power). The obtained results showed that the three organs of Pistacia atlantica are rich in total phenols, flavonoids, and condensed tannins. The highest contents of total phenols and flavonoids are recorded by the crude fruit extract, 723 mg EGA/gE and 34.57 mg EQ/gE, respectively, while the highest content of condensed tannins is recorded in the butanolic extract of the leaves (997.58 mg ECat/gE). The antioxidant activity of the three organs extracts from Pistacia atlantica Desf. confirmed their strong antiradical power, much higher than that of ascorbic acid and BHA (butylated hydroxyanisole). Indeed, the concentration of the crude extract of P. atlantica leaves reducing 50% of the DPPH ∗ free radicals (IC50) is 27.22 μg/ml. This concentration is much lower than those of ascorbic acid (31.44 μg/ml) and BHA (46.25 μg/ml). The antioxidant power using the FRAP method has also shown that the leaves extract of this species has a much higher reducing capacity of iron than those of the reference standards. A positive correlation between antioxidant capacities and flavonoids contents of leaves and fruits extracts was observed. The two methods (DPPH ∗ and FRAP) proved that the three organ extracts of Pistacia atlantica possess very remarkable antioxydant activity. These extracts could be exploited as natural antioxidants against the oxidation phenomenons and the oxidative stress in several fields (food, cosmetic, pharmaceutic, and others).
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Mbanga, L. "Antioxidant Properties of Some Plants Extracts Used As Natural Sunscreen in the Formulated Cream." Revue Congolaise des Sciences & Technologies 02, no. 01 (2023): 185–90. http://dx.doi.org/10.59228/rcst.023.v2.i1.23.
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The aim of the present research is to study the antioxidant properties of eight seeds [carrot, Moringa oleifera, soya bean, coconut, Cucurbita maxima (Ccm), palm walnut (Pmw), Vigna unguiculata called niebe and Citrullus lanatus (Ctl)] extracts using radical DPPH as model in view of their possible application as antisolar agents. Ethyl acetate seed extracts were prepared with methanol as solvent and the absorbance were recorded after reaction with the radical DPPH using UV-vis spectrophotometer. The EC50, the antiradical power (ARP) and the stoechiometry of eight seeds extracts were determinated. It was noticed that three of the tested herbal extracts namely carrot, Pmw and niebe showed some antioxidant properties. The carrot extracts gave the better results with an EC50, an ARP and a stoechiometry of 1.12, 0.89 and 0.45 respectively. Five seeds extracts (Ccm, moringa, Ctl, coconut and soya) didn't show antioxidant properties. Thus, the carrot extracts are most active whereas five samples did not show reactivity towards radical DPPH. Keywords: Antioxidant properties, EC50, antiradical power (ARP), Citrullus lanatus, Moringa oleifera
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Ismaili, Rachid, Sara Houbairi, Lanouari Sanâa, Moustaid Khadija, and Lamiri Abdeslam. "Etude De L’Activité Antioxydante Des Huiles Essentielles De Plantes Aromatiques Et Médicinales Marocaines." European Scientific Journal, ESJ 13, no. 12 (2017): 323. http://dx.doi.org/10.19044/esj.2017.v13n12p323.
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Morocco is a traditional supplier of medicinal and aromatic plants to the world. This activity has resulted to the exploitation of wild plants than dried plants for herbal needs and food flavors. Many species are used for the production of plant extracts and other aromatic essences mainly for the pharmaceutical and cosmetics industry. Among these metabolites, there are essential oils that are mixtures of aromatic substances present in the form of tiny droplets in the leaves, fruit peel, resin, branches, and wood. These oils, however, is endowed with antioxidant properties. This study aims to evaluate the antioxidant activity of essential oils of three moroccan aromatic and medicinal plants: Thymus vulgaris, Mentha spicata, and Citrus limonum. The oil extraction was performed by steam distillation in a Clevenger type apparatus. Also, the antioxidant activity of these oils was evaluated by the method of DPPH (2,2-diphenyl-1-picrylhydrazyl), in comparison with the antioxidant synthetic, ascorbic acid. In the present work, the results showed that the antioxidant activity of three essential oils studied by the trapping method of free radical is moderate. Also, the oil of Thymus vulgaris has a strong activity which exceeds that of ascorbic acid. This was followed by the oil of Mentha spicata, while the lowest activity was observed in Citrus limonum.
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Chaalal, Makhlouf, Siham Ydjedd, and Sana Mansouri. "Phenolic compounds and antioxidant activity of different parts of three mandarin varieties extracts: A comparative study." North African Journal of Food and Nutrition Research 4, no. 08 (2020): 318–24. http://dx.doi.org/10.51745/najfnr.4.08.318-324.
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Background: Mandarin by-products, such as peels and seeds, are considered as one of the naturel sources of phenolic compounds. Aim: The objective of the present study was to compare the phenolic compounds contents and antioxidant activity of different parts (pulps, seeds, juices, and peels) of three mandarins varieties extracts. Material and methods: Total phenolic, flavonoid, and proanthocyanidin contents of the extracts were assessed while, the antioxidant activity was evaluated using three tests including ferric reducing power, free radical scavenging activity, and phosphomolybdate. Results: The Mediterranean Mandarin peels present a high total phenolics and flavonoids contents with values of 2445.62 mg GAE/100g FW and 609.78 mg QE/100g FW, respectively. Likewise, the clementine juice showed the highest proanthocyanins contents with a value of 46.67 mg CE/100g FW. Seeds and pulps of the three varieties present the lowest phenolic compound contents. Mediterranean Mandarin juice showed a strong ferric reducing power and phosphomolybdate with values of 1270.91 and 190.19 mg AAE/100g FW, respectively, however, the peels revealed a strong free radical scavenging activity with value of 259.89 mg AAE/100 g FW. Statistical analysis showed a positive correlation between the antioxidant activity and the phenolic compounds contents of the three studied mandarins varieties extracts. Conclusion: Among the analyzed cultivars, the Mediterranean mandarin variety may be considered as the most promising source of polyphenols and antioxidants, compared to the clementine and Satsuma varieties. Moreover, this study also highlights important properties of the fruit parts generally considered wastes. Keywords: Mandarins, different parts, phenolics compounds, antioxidant activity.
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Galan, Pilar, Nathalie Noisette, Carla Estaquio, et al. "Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort." Public Health Nutrition 9, no. 1 (2006): 70–74. http://dx.doi.org/10.1079/phn2005826.
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AbstractBackgroundIron has been suggested to play a role in the development of cardiovascular disease (CVD) through its pro-oxidant properties. However, epidemiological studies on iron status and the risk of CVD have yielded conflicting results. We therefore carried out a prospective study to evaluate the relationship between iron status and CVD in a middle-aged French population.MethodsIn total, 9917 subjects (3223 men aged 45–60 years and 6694 women aged 35–60 years) included in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort were followed prospectively for 7.5 years. All cases of ischaemic heart disease (IHD) were identified and validated. CVD risk factors, haemoglobin and serum ferritin concentrations were measured at baseline.FindingsOf men 4.3%, and of women 37.8%, presented at baseline a serum ferritin concentration <30 μg l−1. During the follow-up, 187 subjects (148 men, 39 women) developed IHD. Serum ferritin was positively associated with total cholesterol, serum triglycerides, systolic and diastolic blood pressure, body mass index and haemoglobin. No linear association was found between serum ferritin and IHD risk in men or in women.ConclusionOur data do not support a major role of iron status in the development of IHD in a healthy general population.
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De Revel, Gilles, Tim Hogg, and Cristina Santos. "Analysis of cis- and trans-resveratrol in Portuguese wines." OENO One 30, no. 1 (1996): 31. http://dx.doi.org/10.20870/oeno-one.1996.30.1.1116.
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<p style="text-align: justify;"><em>Trans</em>-resveratrol (<em>trans</em>-3,5,4'-trihydroxystilbene) has been reported as contributing to the health promoting properties of wine. In this study wines made exclusively from native Portuguese varieties were assayed for the levels of <em>trans</em>-resveratrol. The method developed uses GC-FID and GC-MS determinations of TMS derivatives; derivatisation by hexamethyldisilazane following ether extraction of wines. Two currently used food antioxydants nordihydroguaiaretic acid (NDGA) and 2' ,4' ,5' -trihydroxybutyrophenone (THBP), were employed as internai standards, being extracted and derivatised in exactly the same way as the determined resveratrol. These internal standards permitted the verification of a good linearity and reproducibility for this determination, with a detection limit of 5 μg/l. A characteristic of this method is the enhanced discrimination between <em>cis</em>- and <em>trans</em>- isomers of resveratrol with the consequent possibility of the determination of <em>cis</em>-resveratrol. The levels of resveratrol from wines of different regions of Portugal was studied. There appeared to be considerable variation in the concentrations encountered in the various wines although generally red wines contained much higher levels than white wines. The use of glucosidase enzymes in winemaking led to an increase of 3 - to 4 - fold in the levels of resveratrol encountered in Vinho Verde wines. Differences were noted between the resveratrol levels of specifie varietal wines from the Vinho Verde.</p>
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Tine, Yoro, Madièye Sene, Khadidiatou Thiam, et al. "Revue des usages traditionnels, composition chimique et propriétés pharmacologiques de <i>Combretum glutinosum</i> (Combretaceae)." International Journal of Biological and Chemical Sciences 17, no. 6 (2024): 2475–89. http://dx.doi.org/10.4314/ijbcs.v17i6.27.
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Combretum glutinosum Perr. ex DC. (Combretaceae) est une plante médicinale largement utilisée en Afrique par les praticiens traditionnels pour le traitement de divers troubles comme les maladies respiratoires, la douleur, le paludisme et les infections microbiennes. En raison de sa large utilisation traditionnelle, dans cette revue, les rapports scientifiques publiés sur sa composition et ses propriétés pharmacologiques ont été explorés en effectuant une recherche documentaire dans les bases de données de Google Scholar, PubMed, Elsevier, ScienceDirect et Scifinder. Les études chimiques ont montré la présence de saponines, de flavonoïdes, d’alcaloïdes, de tanins, de saponines, de glycosides cardiaques, d’anthraquinones, d’acides aminés et de terpénoïdes. Il a été démontré que des extraits de cette plante ainsi que les composés purs qui en ont été isolés, possédaient des propriétés antibactérienne, antiparasitaire, antidiarrhéique, cytotoxique, anti-inflammatoire, hypoglycémiante, antioxydante, antihelminthique et antipaludique, entre autres. Cette revue fournit donc une vue d'ensemble des progrès actuels en matière, d'ethnopharmacologie, de phytochimie, de pharmacologie et de toxicité de C. glutinosum, constituant ainsi une référence pour la Recherche et Développement sur C. glutinosum.
 Combretum glutinosum Perr. ex DC. (Combretaceae) is a medicinal plant widely used in Africa by traditional practitioners for the treatment of various disorders such as respiratory diseases, pain, malaria and microbial infections. Due to its wide traditional use, in this review, published scientific reports on its composition and pharmacological properties were explored by conducting a literature search of Google Scholar, PubMed, Elsevier, ScienceDirect and Scifinder databases. Chemical studies showed the presence of saponins, flavonoids, alkaloids, tannins, saponins, cardiac glycosides, anthraquinones, amino acids, and terpenoids. Extracts of this plant, as well as the pure compounds isolated from it, have been shown to possess antibacterial, antiparasitic, antidiarrheal, cytotoxic, anti-inflammatory, hypoglycemic, antioxidant, antihelminthic and antimalarial properties, among others. This review therefore provides an overview of current progress in ethnopharmacology, phytochemistry, pharmacology and toxicity of C. glutinosum, thus constituting a reference for Research and Development on C. glutinosum.
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NACO, Mohamed El Béchir, Dalane Bernadette COULIBALY, Harouna TIRERA, et al. "Composition phytochimique et activité antioxydante des feuilles de Combretum micranthum G. Don (Combretaceae) collectées dans les régions de Kita (Mali) et de Thiès (Sénégal)." International Journal of Pharmaceutical, Physico-chemical and Nutritional Analysis 1, no. 1 (2021): 34–42. http://dx.doi.org/10.61585/pud-ijppna-v1i1a5.
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The plant kingdom contains a very wide variety of bioactive molecules such as phenolic compounds, terpenes and alkaloids that can exhibit antioxidant properties. The objective of the present study was to determine the phytochemical composition and the antioxidant potential of Combretum micranthum G. Don leaf extracts. After botanical identification according to their organoleptic characters, leaf powder samples were submitted to phytochemical screening carried out by the characterization reactions. Also, the contents of phytochemical groups were determined by spectrophotometry. The antioxidant capacity of the leaf extracts was determined by three methods: ferric ion reducing power method and free radical scavenging methods with 2,2-diphenyl-1- picryl-hydrazyl and 2,2'-azino-bis-(3- ethylbenzothiazoline-6-sulfonic acid). The phytochemical screening showed the presence, in appreciable amount, of tannins, flavonoids, anthocyanins, alkaloids, sterols/triterpenes and saponosides in the samples. Leucoantocyanins, oses/holosides, coumarins and mucilages were found in low quantities with samples from Senegal showing the highest levels. The phytochemical group contents were: 1.127 ± 0.058 to 2.671 ± 0.031 μg/mg for alkaloids, 27.171 ± 0.005 to 48.586 ± 0.019 mg equivalent of gallic acid per gram for polyphenols, 0.713 ± 0.049 to 1.978 ± 0.068 mg equivalent of quercetin per gram dry matter for total flavonoids, 21.122 ± 0.008 to 42.024 ± 0.056 mg equivalent of tannic acid per gram for hydrolyzable tannins and 1.129 ± 0.018 to 4.354 ± 0.043 mg equivalent of catechin per gram dry matter for condensed tannins. The greatest antioxidant potential was observed with sample from Mali with inhibitory concentrations (IC50) of 502.19 ± 4.12; 6.54 ± 2.67; 491.38 ± 11.19 μg/mL respectively by DPPH•, ABTS+• and FRAP methods. This study revealed the presence of a variety of phytochemicals in leaf extracts of Combretum micranthum G.Don with high content of phenolic compounds which can be subsequently correlated to antioxidant potential of this plant.
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Adjibade, Moufidath, Valentina A. Andreeva, Cédric Lemogne, et al. "The Inflammatory Potential of the Diet Is Associated with Depressive Symptoms in Different Subgroups of the General Population." Journal of Nutrition 147, no. 5 (2017): 879–87. http://dx.doi.org/10.3945/jn.116.245167.
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AbstractBackground: Low-grade chronic inflammation, which can be modulated by diet, has been suggested as an important risk factor for depression, but few studies have investigated the association between the inflammatory potential of the diet and depression.Objective: We investigated the prospective association between the inflammatory potential of the diet, measured by the Dietary Inflammatory Index (DII), and incident depressive symptoms and tested the potential modulating effect of sex, age, physical activity, and smoking status.Methods: This study included 3523 participants (aged 35–60 y) from the SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) cohort, who were initially free of depressive symptoms. Baseline DII (1994–1996) was computed by using repeated 24-h dietary records. Incident depressive symptoms were defined by a Center for Epidemiologic Studies–Depression Scale score ≥17 for men and ≥23 for women in 2007–2009. We used multivariable logistic regression models to estimate ORs and 95% CIs, and modeled the DII as a continuous variable and as sex-specific quartiles.Results: A total of 172 cases of incident depressive symptoms were identified over a mean follow-up of 12.6 y. The DII was not associated with incident depressive symptoms in the full sample. In sex-specific models, men with a higher DII had a higher risk of incident depressive symptoms (quartile 4 compared with quartile 1—OR: 2.32; 95% CI: 1.01, 5.35), but the association was only marginally significant (P-trend = 0.06). When analyses were performed across smoking status, current and former smokers with a higher DII had a higher risk of incident depressive symptoms (quartile 4 compared with quartile 1—OR: 2.21; 95% CI: 1.08, 4.52). A positive association was also observed among less physically active participants (quartile 4 compared with quartile 1—OR: 2.07; 95% CI: 1.05, 4.07).Conclusion: The promotion of a healthy diet with anti-inflammatory properties may help to prevent depressive symptoms, particularly among men, smokers, or physically inactive individuals. This trial was registered at clinicaltrials.gov as NCT0027242.
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Никулина, O. Nikulina, Новак, Mikhail Novak, Енгашев, and Syergyey YEngashyev. "Methodical guidelines for diagnostics, treatment and prevention of canine babesiosis in the central area of the Russian Federation." Russian Journal of Parasitology 3, no. 3 (2016): 414–20. http://dx.doi.org/10.12737/21666.
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Objective of research: to study distribution and features of epizootic process at canine babesiosis in the central area of the Russian Federation as well as improvement of diagnostics, treatment and prevention measures.
 Materials and methods: Definition of species composition and number of ticks (Ixodidae) on dogs. Statistical analysis of veterinary reports from regional veterinary stations of the Ryazan region. Laboratory microscopic and serological diagnostic test for canine babesiosis.
 Results and discussion: Seasonal dynamics of activity of ixodid tick Dermacentor reticulatus (April — June and August — October); maximal extensity of invasion with Babesia spp. (75%); average level of parasitemia in acute and super-sharp form of babesiosis in spring and autumn; clinical parameters of non-sterile immunity in adult and young animals; dependence of the degree of the severity of disease on the age of dogs were determined. 
 The maximum parasitemia was observed in young (7-23%) and old (6-30%) animals. The average parasitemia was determined in dogs at the age of 3-7 years were 5-11%. The results of hematological and biochemical research revealed that severe acute canine babesiosis is characterized by erythropenia, decreased level of hemoglobin, haematocrit and thrombocytes, leukocytosis, increased level blood bilirubin (by 3-25 times), urea (1,5-5) and creatinine (1,2-3), reduced glucose level (up to 50%).
 In babesiosis of light and mild severity, the above-mentioned changes of hematological and biochemical parameters in dogs were not significant. Latent canine babesiosis might be diagnosed by serological test (RAHА) on antibodies to Babesia spp. High efficiency of domestic drugs Babesan (EE = 96,5%), Forticarb (EE = 93,3%), Piro-Stop (EE = 90,9%), Veriben (EE = 82,3%), Neosidin (EE = 75%) for babesiosis in dogs was determined.
 The drug Emidonol which has antioxydantic and antihypocsantic properties and was used within 5-7 days for dog treatment, promotes prevention of complications in the form of heart and respiratory failure, and reduction of recovery time. Efficiency of the drug «Bars spot-on» (containing ivermectin) applied against ixodid ticks was detected. Repellent efficiency of the essential oil-based collars «Bar», «Fitodoc» and «Chetyre s hvosticom» used against ixodidosis of dogs, was confirmed, the duration of their action is from 160 to 180 days.
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Igwe, R. O., I. I. Osakwe, J. T. Ogunnupebi, E. N. Okeh, and N. Etim,NseAbasi. "Effect of selenium on growth performance, haematological indices, carcass characteristics and sensory properties of broiler chicken." Nigerian Journal of Animal Production 49, no. 3 (2022): 152–59. http://dx.doi.org/10.51791/njap.v49i3.3545.
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The vital role of selenium in various metabolic reactions and its role as a component of antioxidant enzymes has awaken research interest in livestock production. Its influence on animal fertility, production and disease prevention is subject for on-going research. Deficiency of selenium have serious negative effect on animal skeletal and cardiac muscles which will in turn reduce growth, and there is dearth of information on its effect on growth performance, haematological indices and carcass characteristics of broiler chicken, the reason for this study. An experiment was carried out to investigate the effect of selenium on growth performance, haematological indices, carcass characteristics and sensory properties of broiler birds. Atotal of 120, one-day-old chicks were randomly assigned to four treatments in a completely randomized design and were further divided into three replicates with 10birds per replicate. Selenium was administered orally through their drinking water in three levels such that treatment (T ) served as control. T , T , and T received 0.2mg, 0.4mg, 1 2 3 4 and 0.6mg, respectively. Data were collected on growth performance, haematological indices, carcass characteristics and sensory properties. Results showed selenium significantly (p<0.05) improved the final body weight (FBW), carcass weight, dressed weight of the birds and feed conversion ratio (FCR). Birds onT (2123.33g) had the highest 3 FBW with the least FCR (2.45) compared to those in other treatments. There were no significant (p>0.05) differences on the sensory properties of the meat. Result from the study showed that selenium improved the haematological indices with increased packed cell volume and haemoglobin concentration. Results obtained from this study revealed that the inclusion of selenium especially at 0.4mg level (T ) improved the growth performance, 3 carcass characteristics as well as the health status of the birds without having any detrimental effect on the birds.
 
 
 
 
 Le rôle vital du sélénium dans diverses réactions métaboliques et son rôle en tant que composant des enzymes antioxydantes a réveillé l'intérêt de la recherche dans la production de bétail. Son influence sur la fertilité des animaux, la production et la prévention des maladies est soumise à des recherches en cours. La carence du sélénium présente un effet négatif grave sur les muscles squelettiques des animaux et cardiaques qui réduira à leur tour la croissance et il y a de la pénurie d'informations sur ses effets sur la performance de la croissance, les indices hématologiques et les caractéristiques de la carcasse du poulet à griller, la raison de cette étude. Une expérience a été réalisée pour enquêter sur l'effet du sélénium sur la performance de la croissance, les indices hématologiques, les caractéristiques de la carcasse et les propriétés sensorielles des oiseaux de poulets à griller. Un total de poussins âgés de 120 jours ont été attribués au hasard à quatre traitements dans une conception complètement randomisée et ont été divisés davantage en trois réplicats avec 10 oiseaux par réplication. Le sélénium a été administré par voie orale à travers leur eau potable dans trois niveaux de ce type de traitement (T ) servi de contrôle. T , T et T ont reçu 1 2 3 4 0,2 mg, 0,4 mg et 0,6 mg, respectivement. Les données ont été collectées sur la performance de la croissance, les indices hématologiques, les caractéristiques de la carcasse et les propriétés sensorielles. Les résultats montraient de manière significative sélénium (P<0,05) amélioré le poids corporel final (PCF), le poids de la carcasse, le poids habillé des oiseaux et le rapport de conversion d'alimentation (RCA). Les oiseaux sur T (2123.33g) ont eu le plus 3 haut PCF avec le moins de RCA (2,45) par rapport à ceux d'autres traitements. Il n'y avait pas de différences significatives (p> 0,05) sur les propriétés sensorielles de la viande. Le résultat de l'étude a montré que le sélénium a amélioré les indices hématologiques avec une augmentation du volume de cellules emballées et de la concentration en hémoglobine. Les résultats obtenus à partir de cette étude ont révélé que l'inclusion de sélénium en particulier à 0,4 mg de niveau (T ) a amélioré la performance de la croissance, les caractéristiques de la 3 carcasse ainsi que l'état de santé des oiseaux sans avoir d'effet néfaste sur les oiseaux.
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Adeyemi, D. K., A. O. Adeluola, M. J. Akinbile, O. O. Johnson, and G. A. Ayoola. "Green synthesis of Ag, Zn and Cu nanoparticles from aqueous extract of Spondias mombin leaves and evaluation of their antibacterial activity." African Journal of Clinical and Experimental Microbiology 21, no. 2 (2020): 106–13. http://dx.doi.org/10.4314/ajcem.v21i2.4.
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Background: Nanotechnology offers an advantage as a green route for synthesis of metal nanoparticles (NPs) with plant extracts as capping agent. Spondias mombin is a fruit-bearing tree and its leaf extracts have been reported to possess anxiolytic, hypoglycaemic, antiepileptic, antipsychotic, sedative, antioxidant, and antimicrobial properties. The objective of the study is to determine the antibacterial potential of a simple non-toxic product of green synthesis of metallic (Ag, Zn and Cu) nanoparticles using the leaf of Spondias mombin aqueous extracts (SMAE) as a reducing and capping agents of the metal ions.Methodology: Nanoparticles were characterized by UV visible spectrophotometeric analysis, Fourier Transform Infra-Red (FT-IR) spectrophotometer and scanning electron microscope (SEM). Antimicrobial activities of synthesized NPs against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were determined by agar well diffusion technique.Results: The synthesized NPs varied in colour from dark brown to green and appears dominantly spherical, occasionally rod or triangular shaped with size ranging from 65-90 nm. UV spectroscopy absorption spectra of Ag, Zn and Cu NPs had absorbance peak at 267, 262 and 765 nm respectively. FT-IR spectrometry of Zn NP, Cu NP, and SMAE gave wave number ranging from 895.71-3320.67, 747.02-3225.45 and 658.25-3674.49 respectively. FT-IR analysis showed that SMAE acted as reducing and stabilizing agent while the NPs exhibited lower energy absorption band when compared to the plant extract. The NPs demonstrated higher antimicrobial activities against S. aureus than Ps. aeruginosa and E. coli. The antimicrobial activity was higher with copper NP than Ag and Zn NPs, and also higher than SMAE.Conclusion: The result from this study presents an indication for an alternative means for development of novel antimicrobial agents for clinical and biotechnological applications.Keywords: synthesis, nanoparticles, FT-IR, UV-visible spectrophotometry, antibacterial activitiesFrench Title: Synthèse verte de nanoparticules d'Ag, de Zn et de Cu à partir d'extrait aqueux de feuilles de Spondias mombin et évaluation de leur activité antibactérienneContexte: La nanotechnologie offre un avantage en tant que voie verte pour la synthèse de nanoparticules métalliques (NP) avec des extraits de plantes comme agent de coiffage. Spondias mombin est un arbre fruitier et ses extraits de feuilles possèdent des propriétés anxiolytiques, hypoglycémiques, antiépileptiques, antipsychotiques, sédatives, antioxydantes et antimicrobiennes. L’objectif de l’étude est de déterminer le potentiel antibactérien d’un simple produit non toxique de synthèse verte de nanoparticules métalliques (Ag, Zn et Cu) à l’aide de la feuille d’extraits aqueux de Spondias mombin (SMAE) en tant qu’agent réducteur et coiffant de la ions métalliques.Méthodologie: Les nanoparticules ont été caractérisées par analyse spectrophotométrique UV visible, spectrophotomètre à transformée de Fourier infrarouge (FT-IR) et microscope électronique à balayage (MEB). Lesactivités antimicrobiennes de NP synthétisées contre Escherichia coli, Staphylococcus aureus et Pseudomonas aeruginosa ont été déterminées par une technique de diffusion sur puits d’agar.Résultats: Les NP synthétisés ont une couleur allant du brun foncé au vert et apparaissent principalement sphériques, parfois en bâtonnets ou en triangles, avec des tailles allant de 65 à 90 nm. Les spectres d'absorption par spectroscopie UV des NP Ag, Zn et Cu présentaient des pics d'absorbance à 267, 262 et 765 nm respectivement. La spectrométrie FT-IR de Zn NP, Cu NP et SMAE a donné un nombre d'onde allant de 895,71 à 3320,67, 747,02 à 3225,45 et 658,25 à 3674,49 respectivement. L'analyse FT-IR a montré que le SMAE agissait en tant qu'agent réducteur et stabilisant, alors que les NP présentaient une bande d'absorption d'énergie inférieure à celle de l'extrait de plante. Les NP ont démontré des activités antimicrobiennes plus élevées contre S. aureus que Ps. aeruginosa et E. coli. L'activité antimicrobienne était plus élevée avec les NP en cuivre que dans les NP Ag et Zn, et également supérieure à celle du SMAE.Conclusion: le résultat de cette étude présente une indication d'un autre moyen de développement de nouveaux agents antimicrobiens pour des applications cliniques et biotechnologiques.Mots-clés: synthèse, nanoparticules, FT-IR, spectrophotométrie UV-visible, activités antibactériennes
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Haddi, Rihab, Aicha Maria El Kharraz, and Mimouna Ikram Kerroumi. "Green Synthesis of Zinc Oxide Nanoparticles Using Pistacia lentiscus L. Leaf Extact and Evaluating their Antioxydant and Antibacterial Properties." Nano Biomedicine and Engineering, December 2024. http://dx.doi.org/10.26599/nbe.2024.9290056.
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Anouhe, Jean-Baptiste Say, Florence Bobelé Niamké, Milcard Faustin, et al. "The role of extractives in the natural durability of the heartwood of Dicorynia guianensis Amsh: new insights in antioxydant and antifungal properties." Annals of Forest Science 75, no. 1 (2018). http://dx.doi.org/10.1007/s13595-018-0691-0.
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BENMAAROUF, DAOUIA KELTOUM, DIANA C. G. A. PINTO, BERNARD CHINA, SAFIA ZENIA, KHEIRA BOUZID BENDESARI, and MERIEM HIND BEN-MAHDI. "CHEMICAL ANALYSIS, ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTINOCICEPTIVE EFFECTS OF ACETONE EXTRACT OF ALGERIAN SOLENOSTEMMA ARGEL (DELILE) HAYNE LEAVES." International Journal of Current Pharmaceutical Research, September 17, 2020, 72–81. http://dx.doi.org/10.22159/ijcpr.2020v12i5.39771.
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Objective: To investigate the qualitative composition of the acetonic extract from leaves of S. argel (AESA) and their anti-inflammatory and analgesic properties in vivo.
 Methods: AESA profile was established by UHPLC/DAD/ESI-MS2. AESA was subjected to the acute oral toxicity study according to the OECD-420 method. Antioxydant activity of AESA was performed by DPPH radical scavenging assay. Anti-inflammatory effects of AESA were determined in two animal models: carrageenan-induced paw edema in rats and cotton pellet-induced granuloma formation in rats. Further, anti-nociceptives activities of AESA were assessed by hot plate test, acetic acid-induced abdominal writhing test and formalin test.
 Results: The in vivo AESA toxicity was low. AESA expresses a maximum radical scavenging activity with a IC50 value of 36,05 μg/ml. The AESA at 250 and 400 mg/kg significantly reduced carrageen an induced paw edema by 70.09% and 85.53% 6h after carrageenan injection, respectively. AESA produced significant dose-dependent anti-inflammatory effect against cotton pellets-induced granuloma formation in rats. In addition, AESA at 250 and 400 mg/kg significantly reduced acetic acid-induced writhing by 56.83 and 80.41%, respectively. Oral administration of 250 and 400 mg/kg of AESA caused a significant dose dependent anti-nociceptive effect in both neurogenic and inflammatory phases of formalin-induced licking. AESA also impacted the pain latency in the hot plat test.
 Conclusion: These data suggest that AESA possesses antioxidant, anti-inflammatory and anti-nociceptive effects. These results support the traditional use of S. argel to cure pain and inflammatory diseases in the Algerian Sahara.
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Retaileau, Kevin, Eric Belin de Chantemele, annelaure guihot, et al. "Abstract 1443: Angiotensin Ii Type 2 Receptor-dependent Dilation Is Reduced In Type Ii Diabetes Due To Cox-2 Generated Thromboxane A2 And Reactive Oxygen Species." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_297-a.
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The role of angiotensin II type 2 receptors (AT2R) is not fully understood, especially in vascular diseases. Although its vasodilatory and antitrophic properties are well accepted, in hypertensive rats AT2R stimulation induces vasoconstriction. Abnormalities in the renin-angiotensin system have a key role in cardiovascular disorders associated with the evolution of type II diabetes. Thus, we hypothesized that AT2R function might be altered in diabetic rats resistance arteries. Mesenteric resistance arteries (250 μm diameter) were isolated from type II diabetic Zucker (ZDF) and control rats (LZ) rats receiving the antioxidant tempol (16 mg/kg/day) or water for 3 weeks. Dilation to angiotensin II (due AT2R stimulation) in the presence of candesartan (angiotensin II type 1 receptor blocker) was studied in ring segment of arteries using a wire-myograph mesenteric wall force. AT2R induced endothelium and NO-dependent dilation in LZ (inhibited by L-NAME). It was not affected by cyclooxygenase (indomethacin) or reactive oxygen species (ROS) inhibition (TEMPOL). In ZDF rats AT2R-induced dilation was lower than in LZ rats and independent of NO (not inhibited by L-NAME). It was restored to control level after ROS (tempol) and cycloxygenase inhibition (indomethacin). Cycloxygenase-2 (NS398) and Thromboxane A2 receptor (SQ29548) inhibition also restored AT2R-dilation in ZDF rats to control (LZ) level. Cycloxygenase-2 and ROS were overexpressed (immuno-histological detection using confocal microscopy) in ZDF rats arteries. In ZDF rats chronically treated with the antioxydant Tempol (SOD mimetic) AT2R-induced dilation was equivalent to that in LZ (control) rats and it involved NO and cycloxygenase-2-derivatives in equivalent proportion (dilation inhibited in part by L-NAME and by NS398). In tempol-treated rats SQ29548 had no effect. We conclude that in type II diabetic rats AT2R induced dilation is reduced due to ROS and thromboxane A2-dependent vasoconstriction due to COX-2 activation. Chronic treatment of diabetic rats with tempol restored AT2R-dependent dilation through the suppression of ROS and TxA2 production. These findings might be important to consider in the choice of vasoactive drugs in diabetic patients.