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Littérature scientifique sur le sujet « Antiulcer modals »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "Antiulcer modals"

Sruthi, Y.* Dr. Vishnu Kangralkar. "A Comprehensive Review of Experimental Models, Evaluation Parameters, And Natural-Synthetic Therapeutics for Peptic Ulcer Treatment." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 929–46. https://doi.org/10.5281/zenodo.15350568.

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Peptic ulcer disease (PUD) is a gastrointestinal disorder resulting from an imbalance between aggressive factors such as gastric acid and pepsin, and the protective mechanisms of the gastrointestinal mucosa. Common causes include Helicobacter pylori infection, excessive use of non-steroidal anti-inflammatory drugs (NSAIDs), alcohol intake, smoking, and dietary imbalances. Conventional therapeutic approaches, including proton pump inhibitors (PPIs) and histamine-2 receptor antagonists, have proven effective but are often associated with adverse effects, drug interactions, and high recurrence ra

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Mishra, Abhinav P., Ankit Bajpai, and Suresh Chandra. "A Comprehensive Review on the Screening Models for the Pharmacological Assessment of Antiulcer Drugs." Current Clinical Pharmacology 14, no. 3 (2019): 175–96. http://dx.doi.org/10.2174/1574884714666190312143846.

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Background:Due to inappropriate diet, smoking, alcohol consumption, regular use of drugs like NSAIDs and sedentary lifestyle, one may feel upper abdominal pain which may be the predictor of the gastrointestinal disorder called Peptic Ulcer. When an imbalance occurs between the defensive factor and aggressive factor of the stomach, ulcer formation in the esophageal lining, stomach, or duodenum takes place. This leads to the formation of small sores that cause pain. Another condition that synergizes the abdominal pain is vomiting materials which look like coffee grounds, blood in the stool, blac

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Rameshwari, K. sudha, and Ayshwarya M. "EVALUATION OF ANTIULCEROGENIC ACTIVITY OF METHANOL EXTRACTS OF BRASSICA OLERACEA VAR. CAPITATA RUBRA ON ALBINO RAT GASTRIC ULCERATION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 314. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16217.

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ABSTRACTObjective: To investigate the antiulcerogenic activity of methanolic extract of Brassica var. capitata rubra in albino rats.Methods: To evaluate the antiulcer activity by pyloric ligation models experimentally induced gastric ulcer by ranitidine (10 mg/kg) subcutaneously.The parameters taken to assess antiulcer activity were free acidity, total acidity, volume of gastric juice, PH, ulcer score, and ulcer index.Results: The methanolic extract of Brassica oleracea var. capitata rubra in the dose of 0.50 mg/kg produced significant antiulcer activity. The controlanimals had ulcers and hemo

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Srikanth, J., and P. Muralidharan. "Antiulcer Activity of Morinda Citrifolia Linn Fruit Extract." Journal of Scientific Research 1, no. 2 (2009): 345–52. http://dx.doi.org/10.3329/jsr.v1i2.1625.

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The study was designed to investigate the antiulcer activity of ethyl acetate extract of the fruits of Morinda citrifolia Linn (Rubiaceae) using different models of gastric and duodenal ulceration in rats. Gastric ulcers were induced by oral administration of ethanol, aspirin and by pyloric ligation and duodenal ulcers were induced by oral administration of cysteamine HCl. The extract was administered at a dose of 200 and 400 mg/kg orally 30 min prior to ulcer induction. Ranitidine (50 mg/kg) was used as a reference standard. The antiulcer activity was accessed by determining and comparing the

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Goulart, Yara Cavalcante Fortes, Vania Ramos Sela, Simoni Obici, et al. "Evaluation of gastric anti-ulcer activity in a hydro-ethanolic extract from Kielmeyera coriacea." Brazilian Archives of Biology and Technology 48, no. 2 (2005): 211–16. http://dx.doi.org/10.1590/s1516-89132005000200007.

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The antiulcer activity of a hydro-ethanolic extract prepared from the stems of Kielmeyera coriacea Mart. (Guttiferae) was evaluated in rats employing the ethanol-acid, acute stress and Indomethacin models to induce experimental gastric ulcers. Treatment with K coriacea hydro-ethanolic extract provided significant antiulcer protection in the ethanol-acid and Indomethacin models, but not in the acute stress model. These results suggested that the K coriacea hydro-ethanolic extract increased resistance to necrotizing agents, providing a direct, protective effect on the gastric mucosa.

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Mekonnen, Alefe Norahun, Seyfe Asrade Atnafie, and Mohammedbirhan A. Wahab Atta. "Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents." Evidence-Based Complementary and Alternative Medicine 2020 (April 9, 2020): 1–11. http://dx.doi.org/10.1155/2020/2809270.

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Background. Peptic ulcer disease causes significant mortality and morbidity. Plant kingdom provides a useful source for the development of new antiulcer agents. Croton macrostachyus is traditionally used to treat peptic ulcer in Ethiopia. This study aimed to evaluate the antiulcer activity of C. macrostachyus root extracts in rodents using different models. Methods. The crude extract was obtained by cold maceration in 80% methanol and fractionated with chloroform, ethyl acetate, and distilled water. The antiulcer activity was evaluated using pylorus ligation-induced ulcer model in Sprague Dawl

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Thi, Xuan Bui, Loi Vu Duc, Tung Bui Thanh, and Ngoc Tran Minh. "Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam." Asian Journal of Chemistry 31, no. 9 (2019): 2125–32. http://dx.doi.org/10.14233/ajchem.2019.22156.

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Five compounds (1-5) were isolated from the leaves of Sanchezia nobilis collected in Nam Dinh province by chromatographic methods. These compounds were identified as: mangiferin (1), β-sitosterol (2), margaric acid (3), ursolic acid (4), oleanolic acid (5). Their structures were elucidated by spectroscopic methods, including mass spectrometry and nuclear magnetic resonance. These compounds were isolated from the leaves of Sanchezia nobilis for the first time. Screening of gastric and duodenal antiulcer effects on indomethacin induced gastric ulcer models showed that n-hexane fraction produced

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Saleem, Uzma, Ejaz Ul Haq, Bashir Ahmad, and Mohammad Saleem. "Anti-ulcer activity of Cestrum nocturnum leaf in ethanol- and indomethacin-induced ulcer models." Bangladesh Journal of Pharmacology 12, no. 3 (2017): 335. http://dx.doi.org/10.3329/bjp.v12i3.32790.

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This study was planned to explore the antiulcer activity of the methanolic and n-hexane extracts of Cestrum nocturnum leaf against ethanol- and indomethacin-induced ulcer models in rats. The rats were administered orally vehicle in normal control group, methanolic and n-hexane extracts at doses 300, 500, 700 mg/kg, in treated groups and omeprazole 20 mg/kg, as standard drug. The gastric tissues/contents were examined to determine the ulcer index, antiulcer activity, gastric pH, gastric juice volume and aci

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Hemamalini, K., Y. Ramulu, and B. Rambabu. "Protective Effect of Raphanus sativus Using by Phytochemical and Antiulcer Activity by Aspirin Induced Gastric Ulcer." Journal of Pharmaceutical Research International 37, no. 1 (2025): 83–89. https://doi.org/10.9734/jpri/2025/v37i17650.

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Raphanus sativus, a widely growing, has been used in traditional medicine for treating many ailments. The objective of the present study was to evaluate the effects of Aspirinic extract of R. Sativus leaves on gastric ulcer. The antiulcer effects of MERS at 100 and 200 mg/kg doses were evaluated on Aspirin gastric ulcer models. The histological changes in gastric tissue of ulcer mice were also determined in aspirin induced models. R. sativus treatment significantly (P < 0.01) reduced the ulcer index and significantly (P < 0.01) increased the gastric pH of both Aspirin and aspirin-induced

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Deshpande, Mangirish, Pearl Dighe, and Sujit Nagare. "A Review of Antiulcer Activity of Some Medicinal Plants." Journal of Drug Delivery and Therapeutics 14, no. 8 (2024): 201–13. http://dx.doi.org/10.22270/jddt.v14i8.6722.

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Peptic ulcer is a gastrointestinal disorder and with increased prevalence. Peptic ulcer is breaking of endothelial lining of stomach and exposing underlying tissues. Peptic ulcer occurs due to high secretion of acid and reduced defensive factors in stomach and duodenum. It is imbalance between aggressive and defensive factors. Non-steroidal anti-inflammatory drugs and Helicobacter pylori infection also increases the risk of peptic ulcer. Indiscriminate use of synthetic drugs leads to adverse effects and concomitant use of antibiotics potentiates drug-drug interaction thus search of drugs from

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Chapitres de livres sur le sujet "Antiulcer modals"

Kumar Dixit, Amit, Avijit Banerji, Julie Banerji, Deepti Dixit, Parvathy G. Nair, and Damodar Gupta. "Bioactive Constituents and Anti-diabetic Activity of the Indian Medicinal Plant Hemidesmus indicus R. Br.: An Overview." In Therapeutic Implications of Natural Bioactive Compounds. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815080025122030012.

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Hemidesmus indicus R. Br. is a laticiferous, slender, and twining shrub, which is found over almost every part of India. Its roots (Anantmul - Sanskrit meaning: endless root) are particularly used extensively as a single drug and in formulations with other plants to treat several ailments. In view of the wide range of medicinal properties claimed in traditional medicine, significant efforts have been made to determine the efficacy of Hemidesmus indicus through pharmacological experiments in vitro and in vivo models. These include analgesic, anti-inflammatory, antipyretic, antioxidant, antiarth

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