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Thèses sur le sujet « Application to cancer therapy »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Roberts, Fiona L. "Cancer therapy : origin and application." Thesis, University of Strathclyde, 2012. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=16930.

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In this thesis we use mathematical techniques to model two biological systems. First, we examine the growth dynamics of the antibiotic producing bacteria Streptomyces coelicolor and present a system of PDEs. We study the system both numerically and analytically. Due to oscillations in the numerical solution when solved using NAG, which uses a finite difference discretization, we change to a finite element discretization which corrects the oscillations. S. coelicolor also produces anticancer drugs, these can be encapsulated during the self-assembly of nanometre-sized vesicles, BPVs (biomimetic

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Roslan, Nuruliza. "Inhibiting Tumor Protein D52 function for anti-cancer therapy application." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/9437.

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Tumor protein D52 (TPD52) is amplified and/or overexpressed in many cancer types. Previously, TPD52 expression has been associated with ERBB2, suggesting these oncogenes may co-operate in cancer pathogenesis. Furthermore, as ERBB2 is known to promote lipogenesis, this led us to hypothesize that TPD52 expression may be associated with lipogenic phenotypes. RNA interference approaches investigated the effects of depleting TPD52 and ERBB2 in breast cancer cell lines with differing TPD52 and ERBB2 gene amplification and/or expression status. Transient TPD52 knock-down in the ERBB2-amplified brea

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3

Cheng, Wing-Shing. "TARP Promoter-Based Prostate Cancer Gene Therapy : From Development to Application." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5736.

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4

Hobson, N. J. "Nanoparticle theranostics for applications in cancer diagnostics and cancer therapy." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1546610/.

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Traditionally, medicine has been conducted using a diagnostic procedure followed by an appropriate therapy and monitored were possible. On the whole, these steps have happened independently of each other. In recent years however many have started to question this independent approach and have asked whether technologies that seek to combine diagnostics and therapies would be more beneficial at treating diseases. This new medical discipline has been termed theranostics. The aim of this project was to design and synthesise a novel theranostic nanoparticle, using a micelle forming amphiphilic carb

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5

Hawwa, Ahmed Fayeq. "Application of pharmacokinetics and pharmacogenomics to tailor anti-cancer and immunosuppressive therapy." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486218.

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In the research presented in this thesis, the application of pharmacokinetic principles and pharmacogenetic tools to enhance therapeutic drug monitoring of the anti-cancer and immunosuppressive medications (6-MP and AZA) in two patient populations (paediatric patients with ALL and adults with IBD) was investigated. Before a pharmacokinetic analysis was conducted, a valid and reliable microanalytical method for the rapid, simultaneous and accurate determination of 6-MP and four of its metabolites from small volumes (200JlL) of plasma and erythrocytes was developed (Chapter 2). The developed met

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6

Silva, Ana Sofia Matias da. "Design and production of new nanodevices for future application in cancer therapy." Master's thesis, Universidade da Beira Interior, 2011. http://hdl.handle.net/10400.6/1054.

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Nanotechnology is a multidisciplinary area of research that involves different knowledgements from, like life sciences, engineering and medicine. It has been used for different applications such as molecular imaging, molecular diagnosis and also targeted therapy. So far, ddifferent nanoscale devices have been produced, among them, inorganic nanoparticles, dendrimes, lipossomes, polymeric micelles, polymeric nanoparticles, nanotubes and nanofibers are some of the examples. Some of these particles exhibit unique optical and electrical properties allowing their course identification and precise l

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7

Tsedev, Uyanga. "Engineering M13 bacteriophage platforms for cancer therapy applications." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/103838.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 46-48).<br>Two novel schemes for engineering M13 bacteriophage for application in the diagnosis, imaging and treatment of human tumors are proposed. Firstly, by exploiting the uniquely malleable biology of the M13 filamentous phage, we have engineered filamentous phages of shorter lengths by constructing our own set of small viral ssDNA that are packaged by M13 capsid proteins. These 'inho' phages can be sized to

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Hauser, Anastasia K. "PEPTIDE-FUNCTIONALIZED MAGNETIC NANOPARTICLES FOR CANCER THERAPY APPLICATIONS." UKnowledge, 2016. http://uknowledge.uky.edu/cme_etds/59.

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Lung cancer is one of the leading causes of cancer deaths in the United States. Radiation and chemotherapy are conventional treatments, but they result in serious side effects and the probability of tumor recurrence remains high. Therefore, there is an increasing need to enhance the efficacy of conventional treatments. Magnetic nanoparticles have been previously studied for a variety of applications such as magnetic resonance imaging contrast agents, anemia treatment, magnetic cell sorting and magnetically mediated hyperthermia (MMH). In this work, dextran coated iron oxide nanoparticles were

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9

Huth, Christopher. "Development of Multifunctional Nanoparticles for Cancer Therapy Applications." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352401861.

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10

JAFER, RASHIDA. "Laser plasma protons and applications in cancer therapy and proton radiography." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7457.

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Recent developments in high power, ultrashort pulse laser systems enable laser intensities beyond 10^21 W/cm^2 to be achieved. When focused onto thin foil targets, plasmas with extremely high electrostatic fields (>10^12V/m) are produced, resulting in the acceleration of protons/ions to very high energies (~60MeV). During my PhD, I have worked on experimental investigations into proton acceleration driven by high power laser pulses. Key to successful deployment of laser proton sources one one side is getting higher proton energies through to achieve the ultimate goal of realising table top mac

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11

Theeranaew, Wanchat. "A SURFACE-BASED DEFORMABLE IMAGE REGISTRATION WITH APPLICATION TO BREAST CANCER RADIATION THERAPY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1200427318.

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Little, Sarah Ann. "Hepatic malignancy neo-adjuvant therapy and surgical management : clinical and in vivo studies /." Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted: no access, contains 3rd party material and therfore cannot be made available electronically, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=26220.

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Thesis (M.Phil.)--Aberdeen University, 2008.<br>Title from web page (Viewed on July 29, 2009). With: Improvement in perioperative outcome after hepatic resection : analysis of 1,803 consecutive cases over the past decade / W. R. Jarnagan ... et al Ann. Surg. 2002: 236(4), 397-407. With: Diabetes is associated with increased perioperative mortality but equivalent long-term outcome after hepatic resection for colorectal cancer / Sarah A. Little ... et al. J. Gastrointest. Surg. 2002: 6, 88-94. With: Tumours of the ampulla and bile ducts / S. A. Little ... et al. in: Current diagnosis and managem

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13

Cui, Xiaoming. "Discontinuous finite/boundary element method for radiative heat transfer with application in laser cancer therapy." Online access for everyone, 2005. http://www.dissertations.wsu.edu/Dissertations/Fall2005/x%5Fcui%5F121805.pdf.

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14

Baillie-Hamilton, Paula. "Applications of magnetic resonance in cancer diagnosis and therapy." Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:72d25d7c-4f5a-4bc4-9fb0-45f758c09d7b.

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15

Johnson, Charles Alan 1957. "A CONTROL SYSTEM FOR THE APPLICATION OF SCANNED, FOCUSSED ULTRASOUND IN HYPERTHERMIA CANCER THERAPY." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/276438.

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Vera, Gomis Pablo de. "Charged particle interaction with biological materials: modelling and application to ion beam cancer therapy." Doctoral thesis, Universidad de Alicante, 2016. http://hdl.handle.net/10045/56995.

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En esta tesis se presenta un estudio teórico sobre la interacción de partículas cargadas aceleradas con materiales de interés radioterapéutico, con miras a su posible aplicación en el tratamiento del cáncer mediante haces de iones. El trabajo se centra en el cálculo de las probabilidades de interacción electrónica (secciones eficaces de excitación y de ionización) de partículas cargadas (haces de iones y de electrones) con materia condensada, incluyendo materiales inorgánicos y orgánicos de interés para el problema estudiado, así como su uso en programas de simulación de la interacción de la r

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17

Godier, Claire. "Développement de cancer sur puce : application au cancer du pancréas." Electronic Thesis or Diss., Université de Lorraine, 2024. http://www.theses.fr/2024LORR0164.

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L'adénocarcinome canalaire pancréatique (PDAC) est considéré comme l'une des formes les plus agressives du cancer du pancréas. En raison des limites des modèles précliniques traditionnels pour simuler la complexité du microenvironnement tumoral, un taux d'échec supérieur à 90 % est observé pour les nouvelles molécules thérapeutiques. Pour pallier cette insuffisance, l'enrichissement des modèles précliniques par l'ajout d'une troisième dimension est devenu nécessaire. Bien que les modèles tels que les sphéroïdes et organoïdes aient été introduits, leur reproductibilité et leur coût demeurent pr

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Mackey, Megan A. "Gold nanoparticles in some chemical and photothermal applications of cancer therapy." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52934.

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Gold nanoparticles exhibit an array of properties, both intrinsic (chemical) and extrinsic (photothermal), that can be exploited for their use in cancer therapeutics. Owing to their size and ease with which they can be functionalized with various ligands, gold nanoparticles represent a class of highly functional biomedically relevant nanostructures. Here, we explore the use of gold nanoparticles as intrinsic (chemical) antineoplastic agents, with their ability to cause DNA damage and cytokinesis arrest, to induce apoptosis in a metallic composition-dependent manner, as well as their ability to

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19

Evans, J. P. "Development of a murine model of colorectal cancer : application to the optimisation of irinotecan therapy." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3010630/.

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20

Musazzi, U. M. "TRANSDERMAL AND TRANSMUCOSAL PHARMACEUTICAL DOSAGE FORMS FOR PALLIATIVE CARE IN CANCER THERAPY." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/232411.

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Pain is recognized as one of the most distressing cancer-related syndromes and treatment side effects and is linked to decreased quality of life among patients. Despite the improvements of pain management guidelines proposed in the last decades, therapeutic issues are still unsolved, above all in the treatment of loco-regional painful symptoms. For example, a proper pharmacological therapy to treat cisplatin-induced ototoxicity is not currently available. Pain associated to cutaneous wounds is treated by an off-label use of systemic analgesics with high incidence of related side effects. Conve

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21

Meenach, Samantha Ann. "SYNTHESIS AND CHARACTERIZATION OF MAGNETIC HYDROGEL NANOCOMPOSITES FOR CANCER THERAPY APPLICATIONS." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/108.

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Currently, cancer is the second leading cause of death in the United States. Conventional cancer treatment includes chemotherapy, radiation, and surgical resection, but unfortunately, all of these methods have significant drawbacks. Hyperthermia, the heating of cancerous tissues to between 41 and 45°C, has been shown to improve the efficacy of cancer therapy when used in conjunction with irradiation and/or chemotherapy. In this work, a novel method for remotely administering heat is presented. This method involves heating of tumor tissue using hydrogel nanocomposites containing magnetic nanopa

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Dhami, Archana. "Approaches to new DNA-repair inhibitors for applications in cancer therapy." Thesis, University of Bath, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512320.

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5-Aminoisoquinolin-1(2H)-one hydrochloride (5-AIQ.HCI) is a potent, water-soluble PARP-1 inhibitor that exhibits outstanding activity in a wide range of disease models in vivo. The aim of this project is the design and synthesis of derivatives with substituents at the 4-positoin of 5-AIQ. The modes of cyclisation of methyl 2-(substituted)alkynyl-3-nitrobenzoates with different electrophiles (ICI, PhSeCI, HgSO4) were studied. The exclusive formation of isocoumarins demonstrates the influence of the nitro group in directing electrophile-driven cyclisations towards the 6-endo-dig mode. The crysta

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23

Moussounda, Moussounda Koumba Tataye. "Synthèse d'alcoxyamines inédites photolabiles : application en thérapie photodynamique pour le cancer." Electronic Thesis or Diss., Aix-Marseille, 2020. http://www.theses.fr/2020AIXM0315.

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La thérapie photodynamique (PDT) est une méthode actuellement utilisée pour lutter contre certains cancers. La PDT nécessite une molécule photoactivable appelée photosensibilisateur (PS) qui génère, par action avec l’oxygène impulsée par la lumière ultra-violette, la formation d'espèces réactives de l'oxygène notamment l’oxygène singulet très réactif, menant à la mort cellulaire. Même si la PDT est utilisée avec succès pour traiter le cancer de la prostate par exemple, cette méthodologie pose des inconvénients majeurs ; 1)- Manque de sélectivité de la plupart des PSs, 2)- Présence d'oxygène po

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24

Vile, Douglas J. "Statistical modeling of interfractional tissue deformation and its application in radiation therapy planning." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3675.

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In radiation therapy, interfraction organ motion introduces a level of geometric uncertainty into the planning process. Plans, which are typically based upon a single instance of anatomy, must be robust against daily anatomical variations. For this problem, a model of the magnitude, direction, and likelihood of deformation is useful. In this thesis, principal component analysis (PCA) is used to statistically model the 3D organ motion for 19 prostate cancer patients, each with 8-13 fractional computed tomography (CT) images. Deformable image registration and the resultant displacement vector fi

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25

Luo, Phoebe Lihong. "Development of improved expression vectors and their applications in cancer gene therapy." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/280431.

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Recombinant DNA vectors are fundamental tools in gene therapy research. A novel cloning system, pLinus, was made to facilitate vector construction by providing 32 unique restriction sites to adapt DNA fragments in a single step. To compensate the low delivery efficiency of the non-viral vector systems, we have constructed two high expression plasmid vectors, pHi1/2, by incorporating a transcriptional amplifier strategy into a single construct. In both pHi1/2 vectors, the amplifier expression cassettes contained two independent transcriptional units. One transcriptional unit contained a transcr

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26

Abada, Zahra. "Synthèse de porphyrines chirales : application en oxydation asymétrique et application antiparasitaire et anticancéreuse." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114806.

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Les molécules chirales représentent environ 60% des médicaments présents sur le marché pharmaceutique et plus de 80% des médicaments en développement avec plus de 150 milliards de dollars de chiffre d’affaire pour l’année 2002. Les intermédiaires chiraux sont fortement demandés dans l’industrie pharmaceutique atteignant 15 milliards de dollars de chiffre d’affaire en 2009. D’autres domaines en sont demandeurs avec une répartition d’environ 15% dans l’agrochimie et 5% pour la parfumerie. L’obtention de composés d’intérêt pharmaceutique de façon asymétrique est un réel défi et une réelle nécessi

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Nofriyanti, Lisa. "Physico chemistry analysis radionuclide praseodymium-143 for theraphy cancer application." Thesis, Видавництво СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/10113.

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Maietta, Antonio. "Assessing the efficiency of In Vivo electroporation as a nonviral gene transfer technique and studying its application in antiangiogenic cancer gene therapy and cancer immunotherapy." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31267.

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Electroporation refers to a technique that makes use of electrical pulses to create transient and reversible pores into cellular membranes which allows the passage of drugs and macromolecules, such as plasmid DNA, into the cell's interior. It is a widely used laboratory procedure for the transfection of cultured mammalian cells, plant cells and bacteria. Only recently has in vivo electroporation been used for the transfer of genetic material into living tissue, such as muscle, hepatocytes, and tumors of experimental animals. Using a luciferase assay, we have shown that electroporation-mediated

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29

Mott, Landon Alexander. "TOWARDS THE RATIONAL DESIGN AND APPLICATION OF POLYMERS FOR GENE THERAPY: INTERNALIZATION AND INTRACELLULAR FATE." UKnowledge, 2019. https://uknowledge.uky.edu/cme_etds/99.

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Gene therapy is an approach for the treatment of acquired cancers, infectious disease, degenerative disease, and inherited genetic indications. Developments in the fields of immunotherapies and CRISPR/Cas9 genome editing are revitalizing the efforts to move gene therapy to the forefront of modern medicine. However, slow progress and poor clinical outcomes have plagued the field due to regulatory and safety concerns associated with the flagship delivery vector, the recombinant virus. Immunogenicity and poor transduction in certain cell types severely limits the utility of viruses as a delivery

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Souchon, Rémi Chapelon Jean-Yves. "Application de l'élastographie à l'imagerie du cancer de la prostate et à sa thérapie par ultrasons focalisés rostate cancer detection and HIFU therapy monitoring using elastography /." Villeurbanne : Doc'INSA, 2005. http://docinsa.insa-lyon.fr/these/pont.php?id=souchon.

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Thèse doctorat : Images et Systèmes : Villeurbanne, INSA : 2004.<br>Thèse rédigée en anglais. Introduction et conclusion en français et en anglais. Titre provenant de l'écran-titre. Bibliogr. p. 113-118. Publications de l'auteur, 3 p.

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Mooney, Marie R. "Precision Medicine Approaches to Integrating Genomics with Cancer Therapy| Applications in Glioblastoma and Lymphoma." Thesis, Van Andel Research Institute, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10275288.

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<p> The word "cancer" rarely stands alone, usually prefaced with its anatomical location: lung cancer, prostate cancer, brain cancer. With the advancement of high-throughput omics approaches, specific oncogenic events are reorganizing the landscape of cancer classification, at once creating commonalities between cancers arising in diverse anatomical locations and dividing organ-centric classifications of cancer into a multitude of subtypes. The term "precision medicine" postulates that these new, data-driven groupings based on molecular characterization are the key to making rational therapeut

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Weinschenk, Toni. "Multi-peptide-based vaccines for personalized cancer therapy analytical fundamentals translated into clinical applications /." [S.l. : s.n.], 2004. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10976223.

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Bagley, Alexander Francis. "Optically-Active Nanomaterials for Diagnostic and Therapeutic Applications in Ovarian Cancer." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11517.

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The clinical management of cancer has principally relied upon surgery, radiation therapy, and chemotherapy for many decades. Despite recent advances in molecularly-targeted diagnostic and therapeutic agents, the long-term survival rates in patients with solid malignancies including ovarian cancer have improved only incrementally. Nanotechnologies designed to locally interrogate and modulate the tumor microenvironment offer a promising opportunity to enhance existing treatment modalities and establish new therapeutic paradigms. By virtue of their elemental composition, geometry, and surface che

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Böhlen, Till Tobias. "Monte Carlo particle transport codes for ion beam therapy treatment planning : Validation, development and applications." Doctoral thesis, Stockholms universitet, Fysikum, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-81111.

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External radiotherapy with proton and ion beams needs accurate tools for the dosimetric characterization of treatment fields. Monte Carlo (MC) particle transport codes, such as FLUKA and GEANT4, can be a valuable method to increase accuracy of dose calculations and to support various aspects of ion beam therapy (IBT), such as treatment planning and monitoring. One of the prerequisites for such applications is however that the MC codes are able to model reliably and accurately the relevant physics processes. As a first focus of this thesis work, physics models of MC codes with importance for IB

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35

Wong, Yuk-na, and 王玉娜. "The potential applications of AMPK activator resveratrol and PAK1 inhibitor IPA-3 in cancer therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45165208.

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Ahmed, Omar. "Contribution of capillary electrophoresis for the therapeutic drug monitoring of patients treated by targeted cancer therapy : application to tyrosine kinase Inhibitors." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS148.

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L'objectif de ce travail de thèse était d’évaluer l’apport de l'électrophorèse capillaire (EC) comme technique analytique pour la quantification des inhibiteurs de la tyrosine kinase (ITKs) présents dans des échantillons plasmatiques humains dans le contexte du STP. 4 ITKs ont été sélectionnés pour cette étude: mesylate d’imatinib, chlorhydrate d’erlotinib, ditosylate de lapatinib et sorafenib. Tout d’abord, une méthode simple, rapide et peu couteuse a été développée par électrophorèse capillaire de zone (CZE) avec détection UV. Cette méthode reposait sur l’utilisation d’une méthode de prépara

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Lopez, Sara. "Destruction du microenvironnement tumoral par application de forces mécaniques exercées par des nanoparticules magnétiques." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30202.

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L'efficacité des traitements conventionnels du cancer est en partie limitée par l'acquisition de résistances par les cellules cancéreuses. Ces résistances ont longtemps été considérées comme étant le seul fait du génotype des cellules cancéreuses. Cependant, ces dernières années, les chercheurs ont prouvé que la progression et la résistance du cancer n'étaient pas uniquement déterminées par les caractéristiques inhérentes aux cellules cancéreuses, mais également par leurs interactions avec le microenvironnement tumoral. Les fibroblastes associés au cancer (CAFs), font partie du microenvironnem

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Fernandez-Fernandez, Alicia. "IR820 Nanoconjugates for Theranostic Applications." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/819.

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Near-infrared dyes can be used as theranostic agents in cancer management based on their optical imaging and localized hyperthermia capabilities. However, their clinical translatability is limited by issues such as photobleaching, short circulation times, and non-specific biodistribution. We studied the applications of IR820 in optical imaging and hyperthermia, and we prepared nanoconjugate formulations to overcome some of the aforementioned limitations. Free IR820 can be used for optical imaging, with a strong signal still present 24 hours after i.v. injection, an elimination plasma half-life

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Beyrath, Julien. "Development and biological characterization of synthetic molecules targeting Death Receptor 5 : potential applications in cancer therapy." Strasbourg, 2010. http://www.theses.fr/2010STRA6288.

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L’échappement à l’apoptose est une caractéristique majeure responsable du développement des cancers. L’apoptose, un mécanisme conduisant à la mort cellulaire et impliqué dans l‘élimination des cellules cancéreuses, peut être induite par la fixation de certains ligands de la famille du TNF (Tumor necrosis Factor) à leur récepteurs de mort. Parmi ces ligands, TRAIL (TNF-related apoptosis- inducing ligand) possède la particularité d’induire la mort des cellules tumorales tout en épargnant les cellules saines. Il existe quatre récepteurs à TRAIL, DR4 et DR5 induisant une signalisation pro-apoptoti

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40

Kostova, Vesela. "Shiga toxin targeted strategy for chemotherapy and cancer immunotherapy application using copper-free « Click » chemistry." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB144.

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Pas de résumé<br>Recently targeted therapies appeared as attractive alternatives to classical antitumoral treatments. The approach, developed on the concept of targeting drug to cancer cells, aims to spear normal tissues and decrease the side effects. This doctoral dissertation focuses on developing new anticancer targeted treatments in the field of chemotherapy and cancer immunotherapy by exploiting an original targeting moiety, the B subunit of Shiga toxin (STxB). Its specific properties, such as, recognition with its receptor Gb3 overexpressed in cancer cells or in antigen-presenting cells,

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Soysouvanh, Frédéric. "Sénescence cellulaire radio-induite : application à l’irradiation pulmonaire en conditions stéréotaxiques." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS465.

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La radiothérapie constitue l’une des principales modalités de traitement des cancers, mais elle est associée à des atteintes radio-induites aux tissus sains. Les cellules endothéliales (CE) du système vasculaire sont connues pour participer à l’évolution de ces lésions. La sénescence cellulaire est un puissant mécanisme suppresseur de tumeurs mais sa persistance est délétère pour l’homéostasie tissulaire. La présence de cellules sénescentes dans les lésions radio-induites est déjà démontrée mais leur rôle reste encore à élucider. Nous avons cherché à identifier et à comprendre les mécanismes m

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Sadat, Md Ehsan. "Probing the Magnetic Relaxation Dynamics and Optical Properties of Superparamagnetic Iron-Oxide (Fe3O4) Nanoparticles for Biomedical Applications." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447689870.

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Hervault, A. M. M. "Development of a doxorubicin-loaded dual pH- and thermo-responsive magnetic nanocarrier for application in magnetic hyperthermia and drug delivery in cancer therapy." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1566981/.

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Magnetic nanocarriers have attracted increasing attention for multimodal cancer therapy due to the possibility to deliver heat and drugs locally. The enhancement of the anti-cancer effect of chemotherapy with application of concurrent hyperthermia has been noticed more than thirty years ago. However, combining magnetic nanoparticles with drug molecules in the same nanoformulation has only recently emerged as a promising tool for the simultaneous application of hyperthermia and chemotherapy. In this work, initial experimentation was primarily focused on the synthesis of magnetic nanoparticles o

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Rétif, Paul. "Modélisation, simulation et analyse numériques de l'interaction nanoparticules-rayons X : applications à la radiothérapie augmentée." Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0023/document.

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Les travaux présentés dans le cadre de cette thèse sont divisés en trois grandes parties qui concernent l’utilisation des nanoparticules métalliques pour augmenter les effets de la radiothérapie. Cette utilisation très particulière des nanoparticules n’a fait l’objet, jusqu’à présent, que d’études précliniques sauf un nano-objet qui fait actuellement l’objet de phases cliniques I et II à l’Institut Gustave Roussy de Villejuif, France. La première partie est une recherche bibliographique qui s’est concrétisée par la parution d’un état de l’art dans une revue internationale. Ce dernier identifie

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Hillerdal, Victoria. "The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-232850.

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In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. Successful treatment of cancer with T-cell receptor (TCR)-modified T-cells was first reported in 2006, and is based on recognition of a specific peptide by the TCR in the context of the MHC molecule. As antigen presentation in tumors is often defective and to avoid MHC-restriction, chimeric antigen receptors (CAR) molecules containing an antibody part f

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Ciampa, M. G. "Application of oligosaccharidic gold nanoparticles to the vaccines for the therapy of breast cancer: synthesis of neu5GcLactose antigen starting from a complex ganglioside mixture." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/156025.

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Gangliosides, sphingolipids containing sialic acid residue(s), are components of the external layer of cell plasma membranes where they are inserted with the hydrophilic head group turned towards the extra cellular environment. In this strategic position, gangliosides contribute to very special cell processes as development, differentiation and oncogenic transformation. Analysis of the tumour associated ganglioside component profile may aid in the characterization of tumour cells and to establish the degree of malignant transformation. Furthermore, gangliosides that become prominently expo

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FELICI, ALESSIA. "Development of discoidal polymeric nanoconstructs for the treatment of cancer disease." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1046417.

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High loading and specific release of therapeutic agents within the tumor microenvironment are key factors in the development of novel nano-based therapeutic systems against cancer. Although drug availability and preferential tumor accumulation improved with advanced drug delivery system for cancer therapy, they still faces challenge in drug encapsulation and retention. Here, Discoidal Polymeric Nanoconstructs (DPNs) were employed to load and systemically deliver both hydrophilic and hydrophobic therapeutic molecules. DPNs appear as disks, with a diameter of about 1 µm and a height of 400 nm, d

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Dolde, Kai [Verfasser], and Joao [Akademischer Betreuer] Seco. "4D magnetic resonance imaging applications towards MR-guided proton therapy of pancreatic cancer / Kai Dolde ; Betreuer: Joao Seco." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1193347327/34.

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Zhang, Chen. "Metal-NHC complexes for anti-cancer applications : gold(I) for antimitochondrial activity and iridium(III) for photodynamic therapy." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30129/document.

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Dans ce travail de thèse, plusieurs groupes de nouveaux complexes d'or(I) à base de carbènes N-hétérocyclique (NHC)contenant des bras amino-aliphatiques et aromatiques avec un potentiel intéressant dans des applications biomédicales ont été synthétisés et entièrement caractérisés. En outre, une série de complexes d'iridium(III) contenant des ligands NHC avec des activités anticancéreuses prononcées pour une application en thérapie photodynamique, a étépréparée et entièrement caractérisée. Le premier groupe représente une famille de complexes cationiques or(I) bis(NHC) contenant des bras latéra

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Fonseca, Leonor Castro da. "Application of nanotechnological delivery systems in pancreatic cancer therapy." Master's thesis, 2018. http://hdl.handle.net/10437/10115.

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Orientação: Pedro Lopes da Fonte ; co-orientação: Catarina Reis<br>The aim of this dissertation is to understand the applications of nanotechnology in the delivery of drugs in pancreatic cancer therapy. It was necessary to realize the pathogenesis of pancreatic cancer, as well as the reasons why conventional therapies currently used do not provide a significant increase in patient survival. Pancreatic cancer is one of the most lethal cancers in the world, mainly because of the inability to diagnose it in a timely manner and the lack of effectiveness of existing treatments. In this way, the dev

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