Littérature scientifique sur le sujet « Arthriti »
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Articles de revues sur le sujet "Arthriti"
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Chiou, CF, L. Wanke, E. Yu et J. Ofman. « AR2 A COST-EFFECTIVENESS ANALYSIS OF BIOLOGICAL TREATMENTS FOR RHEUMATOID ARTHRITI ARTHRITIS ». Value in Health 7, no 3 (mai 2004) : 223. http://dx.doi.org/10.1016/s1098-3015(10)62076-1.
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Ning, Qiaoyi, Xueming Yao, Ying Huang, Lei Hou, Daomin Lu, Yutao Yang, Yamei Zhan, Yiting He et Wukai Ma. « 3-O-Caffeoylquinic acid in Periploca forrestii Schltr extract ameliorates collagen-induced arthritis by inducing IL17/IL23 cells in rats ». Tropical Journal of Pharmaceutical Research 21, no 7 (21 août 2022) : 1445–52. http://dx.doi.org/10.4314/tjpr.v21i7.13.
Texte intégralRésumé :
Purpose: To study the therapeutic effect of 3-O-caffeoylquinic acid (3-O-CQA) from Periploca forrestii extract (PFE) on collagen-mediated arthritis (CIA) in rats, as well as the potential underlying mechanism of action.
Methods: PFE and 3-O-CQA were successively and intragastrically administered to CIA rats. Paw swelling, arthritic scores and H & E staining were used to evaluate the therapeutic effect of 3-O-CQA. Moreover, to determine the effects of PFE and 3-O-CQA on fibroblast-resembling synoviocytes obtained from arthritic subjects (RAFLS), the viability of RAFLS cultured in vitro was measured with MMT, while apoptotic lesions were analyzed by flow cytometry. The levels of IL-6 in CIA and RAFLS were determined by enzyme-linked immunosorbent assay (ELISA), while quantitative reverse transcriptionpolymerase chain reaction (qRT-PCR) and immunoblotting were used to assess their mRNA and
polypeptide levels, respectively.
Results: PFE in 3-O-CQA ameliorated swelling and reduced arthritic scores in CIA rat model, and also decreased cytokine levels (p < 0.05). By decreasing mRNA and protein expressions, 3-O-CQA repressed the phosphorylation of STAT3 and JAK2 as well as the protein levels of IL-23 and RORγt (p < 0.05).
Conclusion: The results of this study show that CIA and RAFLS are ameliorated in rats by 3-O-CQA in PFE through regulation of IL17/ IL23 and Th17 cells. Thus, 3-O-CQA affords a therapeutic strategy for the management of collagen-induced arthritis.
Keywords: Arthriti; Periploca forrestii Schltr extract; 3-O-Caffeoylquinic acid; Interleukin (IL)-17; IL-23; Th17 cells
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Al-Samman, Deena, Nashwan Al-Asaady et Salem Al-Jader. « Combination Therapy with Rituximab and Methotrexate in the Management of Rheumatoid Arthriti ». Annals of Tropical Medicine and Public Health 22, no 10 (2019) : 128–34. http://dx.doi.org/10.36295/asro.2019.221019.
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Francisco, Charo. « Close Family Ties : Familial Interstitial Lung Disease Secondary to Familial Juvenile Idiopathic Arthriti ». Chest 142, no 4 (octobre 2012) : 458A. http://dx.doi.org/10.1378/chest.1389005.
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Desi, Desi. « TATUS KESEHATAN MENTAL PASIEN GOUT ARHTRITIS DI KOTA TOMOHON ». Jurnal Kesehatan Bakti Tunas Husada : Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi 19, no 2 (9 septembre 2019) : 226. http://dx.doi.org/10.36465/jkbth.v19i2.501.
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<span class="fontstyle0">Gout Arthritis </span><span class="fontstyle0">is a disease known as gout, but in certain conditions this disease can cause physical<br />symptoms that are not visible to some people. When there are problems with physical health, other<br />health aspects will also have an impact. The same is true for patients diagnosed with </span><span class="fontstyle0">Gout Arthritis</span><span class="fontstyle0">,<br />not only physical aspects but can affect other aspects, especially when having physical symptoms such<br />as tofi. Mental health is a condition where there is a balance between emotional, behavioral and<br />cognitive. This is the basis of the importance of maintaining mental health for someone who does not<br />have physical health problems and for someone who has a disease such as </span><span class="fontstyle0">Gout Arthritis </span><span class="fontstyle0">patients. The<br />purpose of this study was to find out how mental health status in </span><span class="fontstyle0">Gout Arthritis </span><span class="fontstyle0">patients in Tomohon<br />City. Quantitative research using a descriptive approach was used in this study. Data collection used<br />survey methods with questionnaires. The results showed that the majority of respondents had adequate<br />mental health (80.6%). Based on the results of the study, it was concluded that mental health status in<br /></span><span class="fontstyle0">Gout Arthriti</span><span class="fontstyle0">s patients in Tomohon City was at a sufficient level. These influenced by himself and the<br />environment around them.</span> <br /><br />
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Zuber, Z., K. Kasperkiewicz, M. Michalski, Ł. Eppa, M. Bartłomiejczyk, A. Świerzko, E. Mężyk, M. Noszczyńska et M. Cedzyński. « THU0537 Selected Factors of Complement Lectin Pathway Factors in Polish Children with Juvenile Idiopathic Arthriti ». Annals of the Rheumatic Diseases 74, Suppl 2 (juin 2015) : 394.3–395. http://dx.doi.org/10.1136/annrheumdis-2015-eular.4204.
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ODEWUSI, OO, MJ ABDULMUMIN et OO OLANIYAN. « AN ASSESSMENT OF AUTOIMMUNITY IN ARTHRITIS PATIENTS ». International Journal of Medical Laboratory Research 07, no 01 (2022) : 53–61. http://dx.doi.org/10.35503/ijmlr.2022.7108.
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Objectives: The goal of this study is to estimate autoimmune biomarkers that characterize the development and severity of arthritis, but probably normalize following successful therapy. Materials and methods: In this study a total of 109 subjects were used out of which treated and untreated arthritics were 48 and 44 respectively, the remaining 17 were healthy individuals which were used as control. Samples were collected from patients attending Rheumatology and Orthopedic clinic of Federal Teaching Hospital Ido-ekiti, Ekiti State Nigeria. Antinuclear antibody was estimated using Enzyme Linked Immunosorbent Assay (ELISA) while Lupus Erythematosus cells were ascertained microscopically using Leishman staining technique. All parameters were assessed in treated and untreated arthritic patients relative to healthy subjects. Body mass index was also calculated. Statistical analysis was done using SPSS. Results: Body mass index and Antinuclear antibodies were significantly higher in treated and untreated arthritics compared to control (P<0.05). When treated and untreated arthritics were compared, Body mass index and Antinuclear antibody were found to be significantly higher in untreated arthritics (P<0.05). Antinuclear antibody and Age correlated directly in untreated arthritics. Lupus Erythematosus cell prevalence was found to be higher in untreated arthritics having a percentage Lupus Erythematosus test positivity of 6.8% compared to the 2.1% seen in treated arthritics. Conclusion: It was found that Autoimmunity in arthritics can be significantly lowered through treatment with Arthritic drugs, diets, life style modifications over a period of time. The study suggests that Antinuclear antibody and Lupus Erythematosus estimations could be adopted as markers of diagnosis, prognosis and monitoring of arthritis.
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Bogmat, Ludmila, Anastasia Fadeeva, Nataliya Shevchenko et Viktoria Nikonova. « The state of physical functionning of patients with juvenile idiopathic arthritis in the assessment of quality of life ». 8, no 8 (29 décembre 2021) : 11–21. http://dx.doi.org/10.26565/2617-409x-2021-8-01.
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Summary. Juvenile idiopathic arthritis is a severe chronic childhood disease that affects not only the joints but is also accompanied by various comorbid conditions, among which eye damage (uveitis) is the most common. In addition to a significant impact on the general condition of the child, this disease also affects the main indicators of quality of life: physical activity, emotional activity, activity in educational institutions, and the social sphere. During the period of active study of Juvenile idiopathic arthritis patients quality of life, a decrease in its overall level is noted due to almost all components, but physical activity shows the lowest values in some studies, which is associated with joint damage, activity, and duration of the disease. Objective. To determine the state of physical functioning and assess the overall level of quality of life in patients with JIA, considering the subtype of the disease duration and the therapy complex. Materials and Methods. The study was carried out at SI "Institute for Children and Adolescents Health Care of the NAMS of Ukraine", Kharkiv, from November 2020 till November 2021. There 118 patients with juvenile idiopathic arthritis were examined, including 47 with polyarticular, 43 with oligoarticular, 28 with uveitis-associated subtypes. The investigation involved 77 girls and 41 boys in age from 2 till 18 years old. The therapy by methotrexate was provided in 111 patients, among them 30 had methotrexate with immunobiological therapy (29 adalimumab, 1 – tocilizumab), 6 – sulfasalazine. The disease duration due to disease subtype was in children with polyarthritis – (49,2±6,7), oligoarthritis – (35,4±4,2), uveitis-associated subtypes of juvenile idiopathic arthritis – (76,8±10,2) months. Disease activity was assessed using the Juvenile Arthritis Disease Activity Score 27-joint reduced count questionnaire, functional state according to he Child Health Assessment Questionnaire and quality of life according to PedsQLTM 4.0 Generic Core Scales. Results. It was found that high juvenile idiopathic arthritis activity was observed in 31 (26.2%) patients, equally often in all subgroups of children. Index functional state did not show a significant decrease either in the whole group or in each of the arthritis subgroups. The overall indicator of quality of life in children with juvenile idiopathic arthritis was reduced in the whole group (71.2±1.4 and 72.9±1.4 per week and month). There was no significant difference between the quality of life indicators of boys and girls. at the same time, physical activity indicators were the lowest in the group with polyarticular juvenile idiopathic arthritis, regardless of gender and age of children, and especially low in children with polyarthritis in the first year of the disease. They also turned out to be worse in children with uveitis-associated subtypes of juvenile idiopathic arthritis with the disease from one to three years. The highest level of the physical component of quality of life was observed in children with oligoarthritis older than 14 years and in children under 8 years of age in the uveitis-associated subtypes of juvenile idiopathic arthritis group. There was no significant effect on the physical indicators of quality of life of the start treatment timing. (р≤0,05). Conclusions. A decrease in quality of life and its physical component is typical for children with different types of juvenile idiopathic arthriti (oligoarticular, polyarticular, and uveitis-associated subtypes of juvenile idiopathic arthritis). It has been established that children with polyarticular subtype of arthritis have the greatest decrease in quality of life and physical functioning.
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MA, Dar. « Anti-Arthritic Activity of Leaf of Carissa carandas (L) against Adjuvant- Induced Arthritis in Rat ». Journal of Natural & ; Ayurvedic Medicine 3, no 2 (16 avril 2019) : 1–8. http://dx.doi.org/10.23880/jonam-16000187.
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Background: Carissa carandas (Apocynaceae) also known as Karonda. The plant has been used in Ayurveda, Unani and Homoeopathic system medicine for over thousands of years. The leaves of this plant has shown astringent, antidiabetic, anti-inflammation and anti-pyretic activity and also used in the rheumatism. Objectives: The present investigation was carried out to evaluate the anti-arthritic activity of ethanolic extract of leaf of Carissa carandas against adjuvant - induced arthritis in rat. Materials and Methods: In this study both male as well as female Wister arts were used in the study. Arthritis was induced by injecting 0.1ml of freund’s complete adjuvant intra-dermally into the left hind paw of the rats. The paw volume, hematological, biochemical, radiographic and histopathological study were evaluated. Results: The extract shows significant reduction in the paw volume which was comparable with the standard and treated as well as normal group. The study reveals that extract as well as standard group shows mild reduction of paw volume where as in negative control sclerosis was seen. The changes in haematological parameters adjuvant induced arthritis shown there was significant increase of RBC count and haemoglobin, while there was significant decrease in WBC count and ESR of arthritic rats in comparison to control. The biochemical parameters such as ALT, ALP, and AST in arthritis induced by CFA group 2 it also showed that the administration of Carissa carandas at doses of 200mg and 400mg/kg in group 4, 5 and standard, in which a significant difference in the triglycerides was found. Conclusion: The effect of anti-arthritic activity of ethanolic extract of leaf of Carissa carandas was investigated in the present study may be due to synergistic effect of phytoconstituents, since the plant contains the active principle which are able to target through multiple mechanisms and which is used in pathophysiology of arthritis.
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Gómez-SanMiguel, Ana Belén, Ana Isabel Martín, Maria Paz Nieto-Bona, Carmen Fernández-Galaz, María López-Menduiña, María Ángeles Villanúa et Asunción López-Calderón. « Systemic α-melanocyte-stimulating hormone administration decreases arthritis-induced anorexia and muscle wasting ». American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 304, no 10 (15 mai 2013) : R877—R886. http://dx.doi.org/10.1152/ajpregu.00447.2012.
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Rheumatoid cachexia is associated with rheumatoid arthritis and it increases mortality and morbidity. Adjuvant-induced arthritis is an experimental model of rheumatoid arthritis that causes anorexia and muscle wasting. α-Melanocyte-stimulating hormone (α-MSH) has anti-inflammatory actions, and it is able to decrease inflammation in several inflammatory diseases including experimental arthritis. In this study we tested whether systemic α-MSH treatment is able to ameliorate cachexia in arthritic rats. On day 8 after adjuvant injection control and arthritic rats were treated with α-MSH (50 μg/rat ip) twice a day, until day 16 when all rats were euthanized. Arthritis decreased food intake, but it increased hypothalamic expression of neuropeptide Y (NPY) and Agouti-related peptides (AgRP) as well as interleukin-1β (IL-1β) and cyclooxygenase-2 (COX-2) mRNA. In arthritic rats, α-MSH decreased the external signs of arthritis and increased food intake ( P < 0.01). In addition, α-MSH decreased hypothalamic expression of IL-1β, COX-2, proopiomelanocortin, and prohormone-converting (PC) enzymes PC1/3 and PC2 mRNA in arthritic rats. In control rats, α-MSH did not modify food intake or hypothalamic expression of aforementioned mRNA. α-MSH prevented arthritis-induced increase in gastrocnemius COX-2, muscle-specific RING-finger protein-1 (MuRF1), and atrogin-1 expression, and it increased fast myofiber size. In conclusion our data show that in arthritic rats peripheral α-MSH treatment has an anti-cachectic action increasing food intake and decreasing muscle wasting.
Thèses sur le sujet "Arthriti"
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Bellan, Mattia. « Vitamin D in Rheumatoid Arthritis : potential implications for disease control and comorbidities management ». Doctoral thesis, Università del Piemonte Orientale, 2018. http://hdl.handle.net/11579/102686.
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Background. Vitamin D is able to regulate the activity of immune system in vitro; whether this action has some relevance in vivo is still a matter of debate. Aim. To investigate the potential role of vitamin D in the pathogenesis and in the management of Rheumatoid Arthritis (RA) and its comorbidities, in particular insulin resistance. Methods. We investigated the expression of tha main target genes implicated in vitami D metabolism on synovial samples obtained from RA and Osteoarthritis (OA) patients; moreover, we evaluated the expression of the CYP27B1, the activating enzyme of vitamin D metabolism, by synovial fibroblasts (SF) of RA patients in vitro. We also investigated, in vivo, the relevance of visceral obesity, assessed by ultrasounds, in the prediction of cardiovascular risk and glucose metabolism in the general population. Finally, we evaluated the cross-sectional association between glucose metabolism
parameters and vitamin D plasma concentration in severely obese diabetic subjects. Results. In the present study we failed to demonstrate significant differences in vitamin D metabolism between RA and OA patients; however, we demonstrated that SF express CYP27B1 under inflammatory state, being potentially able to locally activate vitamin D. Moreover we confirmed that visceral obesity, a well known risk factor for hypovitaminosis D, is the main determinant of insulin resistance and is a strong predictor of cardiovascular risk. Finally, we demonstrated that vitamin D in severely obese type 2 diabetes mellitus patients predicts glycemic control. Conclusions. Our data support the hypothesis that the local conversion of vitamin D could be exploited for therapeutic use in RA; finally, the improvement of vitamin D status might have beneficial effects on different comorbidities related to RA, in particular insulin resistance.
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RAVANI, Annalisa. « Pharmacological characterization of adenosine receptors in chronic inflammatory rheumatic diseases ». Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2478762.
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L’artrite reumatoide, la spondilite anchilosante e l’artrite psoriasica sono malattie infiammatorie croniche, progressive e invalidanti che colpiscono le articolazioni provocando dolore e disabilità. I recettori dell’adenosina giocano un ruolo fondamentale nel meccanismo infiammatorio, in particolare l’attivazione dei sottotipi recettoriali A2A e A3 è spesso associata ad una riduzione dello stato infiammatorio. Il primo obiettivo di questo studio è stato quello di indagare il coinvolgimento dei recettori adenosinici nei pazienti affetti da artrite reumatoide all’esordio della patologia (non ancora in cura), artrite reumatoide, spondilite anchilosante ed artrite psoriasica. L’analisi dell’RNA messaggero (mRNA) e gli esperimenti di saturazione del binding hanno indicato una sovraespressione dei recettori A2A e A3 dell’adenosina nei linfociti ottenuti dai pazienti, comparati con soggetti di controllo sani. Gli agonisti dei recettori adenosinici A2A e A3 sono stati in grado di inibire l’attivazione di NF-κB, un complesso proteico funzionante come fattore di trascrizione. Inoltre hanno ridotto il rilascio di citochine pro infiammatorie, come ad esempio TNF-α, IL-1β e IL-6. Per di più l’attivazione dei sottotipi recettoriali A2A e A3 è stata in grado di mediare una riduzione delle metalloproteasi (MMP)-1 e MMP-3. L’effetto degli agonisti è stato annullato grazie alla somministrazione di antagonisti recettoriali selettivi, dimostrando così il diretto coinvolgimento di questi sottotipi recettoriali. Questi dati confermano l’implicazione dei recettori dell’adenosina nelle patologie reumatiche cronico degenerative evidenziando la possibilità di utilizzare i recettori A2A e A3 dell’adenosina come target terapeutici, con lo scopo di limitare la risposta infiammatoria spesso associata ad artrite reumatoide, spondilite anchilosante ed artrite psoriasica. Lo scopo del secondo capitolo di questa tesi, è stato quello di valutare la modulazione dei recettori A2A e A3 dell’adenosina nei pazienti affetti dalle patologie prese in esame nel primo capitolo, dopo diversi trattamenti farmacologici. Abbiamo indagato sulla densità e la funzionalità recettoriale nella progressione delle patologie attraverso uno studio longitudinale nei pazienti affetti da artrite reumatoide, spondilite anchilosante ed artrite psoriasica prima e dopo le terapie in uso, quali metotressato, agenti anti-TNFα o rituximab. I recettori A2A e A3 dell’adenosina sono stati analizzati attraverso esperimenti di saturazione del binding nei linfociti dei pazienti presi in esame, durante un periodo di ricerca della durata di 24 mesi. Nei linfociti ottenuti dai pazienti affetti da artrite reumatoide, la sovraespressione dei sottotipi recettoriali A2A e A3 dell’adenosina è stata gradualmente ridotta in funzione del tempo di trattamento. Questi risultati confermano il coinvolgimento dei recettori adenosinici A2A e A3 nella progressione delle patologie reumatiche cronico degenerative, sottolineando che gli agonisti dei recettori A2A e A3 dell’adenosina potrebbero rappresentare un’alternativa terapeutica per il trattamento dell’artrite reumatoide.Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are chronic inflammatory rheumatic diseases that affect joints, causing debilitating pain and disability. Adenosine receptors (ARs) play a key role in the mechanism of inflammation, and the activation of A2A and A3AR subtypes is often associated with a reduction of the inflammatory status. The first aim of this study was to investigate the involvement of ARs in patients suffering from early-RA (ERA), RA, AS and PsA. Messenger RNA (mRNA) analysis and saturation binding experiments indicated an upregulation of A2A and A3ARs in lymphocytes obtained from patients when compared with healthy subjects. A2A and A3AR agonists inhibited nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activation and reduced inflammatory cytokines release, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6. Moreover, A2A and A3AR activation mediated a reduction of metalloproteinases (MMP)-1 and MMP-3. The effect of the agonists was abrogated by selective antagonists demonstrating the direct involvement of these receptor subtypes. These data confirmed the involvement of ARs in chronic autoimmune rheumatic diseases highlighting the possibility to exploit A2A and A3ARs as therapeutic targets, with the aim to limit the inflammatory responses usually associated with RA, AS and PsA. The purpose of the second chapter of this thesis, was to evaluate the modulation of A2A and A3ARs in patients suffering from RA, AS and PsA after different pharmacological treatments. We investigated A2A and A3AR density and functionality in pathologies progression by using a longitudinal study in RA, AS and PsA patients before and after methotrexate (MTX), anti-TNFa agents or rituximab treatments. A2A and A3ARs were analyzed by saturation binding assays in lymphocytes from patients throughout the 24-month study timeframe. In lymphocytes obtained from RA patients, the A2A and A3AR up-regulation was gradually reduced in function of the treatment time. Taken together, these data confirmed the involvement of A2A and A3ARs in chronic inflammatory rheumatic disease progression and highlighted that A2A and A3AR agonists could represent a physiological-like therapeutic alternative for RA treatment.
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SILVAGNI, ETTORE. « Tofacitinib improves mitochondrial function in psoriatic arthritis fibroblast-like synoviocytes via autophagy modulation ». Doctoral thesis, Università degli studi di Ferrara, 2022. http://hdl.handle.net/11392/2482880.
Texte intégralRésumé :
Psoriatic arthritis (PsA) is a chronic inflammatory systemic disease, and peripheral joints involvement is responsible of significant morbidity for patients, leading to damage accrual. Different drugs are available for the systemic management of this condition, with different mechanisms of action. Nevertheless, the rules driving the correct therapeutical choice in each individual patient are not completely defined. Janus kinases (JAK) inhibitors are a class of drugs able to reduce synovial inflammation in patients, and tofacitinib, a JAK1/3 inhibitor, is the most studied. Preliminary evidence suggest an effect of tofacitinib on fibroblast-like synoviocytes (FLS), reducing pro-invasive and pro-inflammatory properties, as well as improving mitochondrial function. The link between JAK inhibition and mitochondrial function improvement at synovial level is not completely understood.
Materials and Methods: This is an in vitro study. Patients with active PsA underwent ultrasound-guided synovial biopsy in the context of a tertiary-referral outpatient clinic. Histological evaluation was performed according to Krenn’s synovitis score. FLS, peripheral blood mononuclear cells (PBMCs), and synovial explants cultures were set up, and cells were treated in vitro with tofacitinib 1 µM or vehicle control for 24h. For some experiments, the autophagy-inducer rapamycin was utilized, as well. Protein levels in cellular homogenates were analysed by western blot for relevant autophagy markers, and chemokines/cytokines into culture supernatants were quantified by ELISA. Migration assays were used to investigate the effect of tofacitinib on invasive properties of FLS, while specific mitochondrial probes were used to measure intracellular reactive oxygen species (ROS), mitochondrial potential, and mitophagy. Oxygen consumption rate (OCR), reflecting oxidative phosphorylation, was quantified using the Seahorse technology. Differences were determined adopting the non-parametric Wilcoxon signed rank test.
Results: 16 patients with moderately active PsA were enrolled. Mean (SD) Krenn’s synovitis score was 4.4. (1.9). Tofacitinib significantly increased LC3-II (p=0.0002) and ATG7 (p=0.0001) levels in PsA FLS compared to vehicle control, suggesting an increase in spontaneous autophagy activity. No effect was highlighted in PBMCs and synovial explants cultures. Tofacitinib reduced migration properties of PsA FLS (p=0.0024), and a similar trend was documented using rapamycin. Moreover, tofacitinib reduced MCP-1 and IL-6 release into FLS supernatants (p=0.0007 and p=0.0022, respectively), reduced intracellular ROS production (p=0.0180), increased basal OCR (p=0.02809), ATP production (p=0.0280) and maximal respiratory capacity (p=0.0180), and enhanced mitophagy (p=0.0156).
Conclusion: The JAK inhibitor tofacitinib reduces pro-invasive and pro-inflammatory properties of PsA FLS and improves mitochondrial function. The induction of autophagy/mitophagy by tofacitinib might permit the removal of damaged mitochondria and a better functioning of the remaining ones.
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Innala, Lena. « Early rheumatoid arthritis aspects of severity and co-morbidity ». Doctoral thesis, Umeå universitet, Reumatologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88477.
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Background Rheumatoid arthritis (RA) is a systemic progressive destructive joint disease with an increased risk for co-morbidity and premature death if untreated. Cardiovascular disease (CVD) is the main cause of death but also other co-morbid conditions contribute to the patient’s shorter life expectancy. Inflammation is important for the development of CVD, but knowledge of its relationship with other co-morbidities is sparse. Early disease modifying anti rheumatic drugs (DMARDs) can suppress disease activity and improve the long-term outcome. The aim of this thesis was to evaluate prospectively aspects of disease activity and severity in a large cohort of patients with early RA. Predictive and prognostic markers, e.g., antibodies against citrullinated proteins/peptides (ACPAs), occurring in early disease and with implications for disease outcome and co-morbidity were evaluated. Methods Patients with early RA (i.e., symptomatic for ≤12 months) have, since December 1995, been consecutively included in a large survey of prospective and observational studies on the progression of RA and the development of co-omorbidity. Autoantibodies, inflammatory, genetic markers and radiographs have been analyzed. In paper I, 210 RA patients and 102 controls were followed regularly for two years. The predictive value of four different ACPAs in relation to disease activity and radiological progression was evaluated. In Paper II (n = 700) and in Papers III-IV (n =950), patients with early RA from the four northern-most counties of Sweden were followed regularly for 5 years. Data on risk factors and co-morbidity was collected, according to the study protocol, from clinical records and self-reported questionnaires from patients at inclusion into the study cohort and after five years. The predictive value of traditional and potential disease related risk factors for new cardiovascular events (CVE) was evaluated (II). In Paper III, the impact of age at the onset RA, stratified as being young onset RA (<58 years; YORA) and late onset RA (≥58 years; LORA) on disease activity, severity and chosen treatment, was evaluated. In Paper IV, the development of new co-morbidities after RA onset and their relation to inflammatory activity was assessed. Results The presence of anti-mutated citrullinated vimentin (MCV ) antibodies was associated with a more severe disease course, estimated by disease activity score, erythrocyte sedimentation rate (ESR) and swollen joint count after 24 months, compared with anti-CCP2, anti-CCP3, and anti CCP3.1 antibodies. In Paper II, the incidence of a new CVE during 5 years was explained by several of the traditional CV risk factors, and potentiated by a high disease activity. Treatment with DMARDs decreased the risk. In Paper III, LORA patients were associated with greater disease activity/severity at disease onset and over time compared with YORA who were more often ACPA positive. YORA patients were treated earlier with DMARDs, whilst LORA patients were more often treated with corticosteroids and less so with DMARDs early in the course of their disease. In Paper IV, 53%of patients already had one or more co-morbidities already at the onset of RA. After 5 years, 41% of the patients had developed at least one new co-morbidity. ESR at baseline and accumulated disease activity were associated with a new co-morbidity after five years. Conclusion Early RA patients sero-positive for anti- MCV antibodies appeared to have a higher disease activity over time. The occurrence of a new CVE in early RA patients was predicted by traditional risk factors for CVD which were potentiated by a high disease activity. Treatment with DMARDs decreased the risk. Patients with young onset of RA were associated with a higher frequency of ACPA. Late onset of RA was associated with higher disease activity/severity at inclusion and over time. However, LORA patients were more often treated with corticosteroids and less so with DMARDs early in the disease course. Development of a new co-morbidity during the five years following diagnosis was related to ESR.
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BASSI, ANDREASI Rita. « MULTIDISCIPLINARY APPROACHES AND INTERACTION NETWORK IN THE DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS ». Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2488115.
Texte intégralRésumé :
The multidisciplinary approaches described and reported in the present thesis were performed with the aim to gain new insight into Rheumatoid Arthritis (RA), multifactorial, progressive and autoimmune disease.
The case-control study, focused on the genetic occurrence risk of RA in a complete Italian casuistry, reported the HLA-DQA2 rs9275595 T>C variant strongest associated to RA susceptibility. SNP × SNP investigation revealed significant synergic combined effect between HLA-DQA2 rs9275595 and HLA-DRB1 rs660895 A>G variants, suggesting that, beyond single variant association, the powerful gain arises from interaction between variants belonging to HLA complex.
The predictive biomarkers identification of occurrence, progression and therapy efficacy has been carried out in Undifferentiated Arthritis/ Early Rheumatoid Arthritis patients (UA/ERA). Follow-up after 6 months from the first visit has allowed to stratify subjects accordingly to disease evolution (from UA to RA) and to disease progression (from ERA to RA) using DAS28 variation (Disease Activity Score). Interaction study between genetics and serological parameters reported a significant combined effect of Rheumatoid Factor (RF), resistin and HLA-DRB1 rs6910071 A>G, playing a role together to predict "best responders", the group of patients with higher DAS28 improvement.
Focusing on the influence of sexual dimorphism, a statistical significant gender-dependent effect has been shown in the context of Methtotrexate (MTX) pharmacogenetics: RA women D/I for HLA-G 14bp D>I variant reported significant higher MTX inefficacy, whereas male trend of association was completely opposite. Investigating on women previous obstetric history, it came out the association between the ascertained pregnancies, HLA-G 14bp D/I genotype and MTX inefficacy.
Thus, we focused the approach on the particular women-view, underlying how pregnancy and miscarriage could exert an important and discriminant role in the disease pathogenesis. Pregnancy represents a physiological context requiring immune tolerance toward the fetus and, especially during the first trimester, exists a bidirectional trafficking of cells and DNA in the fetus-maternal interface that can results in naturally acquired microchimerism in both mother (fMC) and fetus. Male fMC could be detected in women bloodstream even after many years from the childbirth and in fact, our findings revealed the presence of male fMC in SLE patients' bloodstream. The widespread symptoms of SLE could justify the higher presence of fMC than which has detected in RA patients' bloodstream and the investigation on localized RA affected synovium might be crucial to understating fMC role. Exploring women synovial biopsies, it failed to reveal positive detection of fMC, empathizing that microchimeric cells can exert a rescue role, acting as stem cells repairing tissues injuries; thus, it has possible to detect fMC cells only in slight or mild RA cases.
Finally, we explored the epigenetic profile, through the methylation analysis of LINE-1 and of specific genes HLA-G and MTHFR. Study has been carried out on healthy subjects, passing through early symptoms, to established RA diseased patients. HLA-G gene was significant hypermethylated in female RA patients, respect to RA males. Significant hypomethylation was identified in MTHFR gene, with a progressive rising to the increase of disease establishment, suggesting that epigenetic state persists beyond RA stages.
In conclusion, the evidences presented in this thesis underlined the interaction network as the important causative factor of RA susceptibility and therapy efficacy. In addition, results on RA affected women emphasized the gender medicine application. Lastly, the epigenetic study is the first to explore methylation status over the time and progression of RA disease, highlighting the environmental contribution and opening new directional window in the RA knowledge.I differenti approcci multidisciplinari affrontati e descritti nella presente tesi sono stati effettuati con l'intento di arricchire le conoscenze in ambito di Artrite Reumatoide (AR), patologia a eziologia multifattoriale, progressiva ed autoimmune. Lo studio caso-controllo, focalizzato sull'individuazione di un profilo genetico di rischio in pazienti italiani con diagnosi di AR, ha riportato la variante HLA-DQA2 rs9275595 T>C significativamente associata ad insorgenza. L'analisi delle interazioni SNP × SNP ha rivelato un significativo effetto sinergico della combinazione fra le varianti HLA-DQA2 rs9275595 e HLA-DRB1 rs660895 A>G, suggerendo che, oltre al singolo effetto, il risultato maggiore si ha dall'interazione fra varianti appartenenti al complesso HLA. L'identificazione di biomarkers predittivi di suscettibilità, di progressione e di efficacia del trattamento impiegato è stata condotta in pazienti con Artrite Indifferenziata/Artrite Reumatoide Precoce (UA/ERA). Il follow-up a 6 mesi ha consentito la stratificazione dei soggetti UA in base all'insorgenza o meno della patologia, mentre per i pazienti ERA in base alla variazione del DAS28 (Disease Activity Score). I risultati delle interazioni genetiche e sierologiche relativamente alla progressione di AR, hanno individuato un algoritmo predittivo di efficacia terapeutica, evidenziando una relazione sinergica fra il Fattore Reumatoide (RF), la Resistina e la variante HLA-DRB1 rs6910071 A>G. Focalizzandosi sullo studio del dimorfismo sessuale, è stato riportato un significativo effetto genere-dipendente nel contesto della farmacogenetica del Methotrexate (MTX): infatti la variante HLA-G 14bp D>I costituisce un fattore predittivo dell'inefficacia del MTX solo nelle pazienti femmine. Approfondendo l'indagine su peculiari caratteristiche del genere femminile che possano interagire con il genotipo HLA-G, è risultata una forte associazione fra la presenza di precedenti gravidanze accertate, il genotipo HLA-G 14bp D/I e l'inefficacia al MTX. Considerando l'elevata espressione di HLA-G a livello del trofoblasto e il suo coinvolgimento nelle poliabortività, è stato indagato il microchimerismo fetale (fMC), già noto per essere presente nel sangue di donne affette da patologie autoimmuni, come AR e Lupus Eritematoso Sistemico (LES), anche dopo molti anni dalla gravidanza o dall'evento abortivo. Lo studio caso-controllo ha rilevato significativa presenza di fMC maschile nel campione ematico periferico di pazienti lupiche. La sintomatologia sistemica di LES potrebbe giustificare l'elevata presenza di fMC maschile nelle pazienti lupiche rispetto alle pazienti AR. Indagando le biopsie sinoviali di donne affette da AR, non è stata rivelata presenza di fMC maschile, suggerendo il possibile ruolo delle cellule microchimeriche come elementi di supporto e di rescue nel miglioramento della patologia. Sarebbe, dunque, possibile individuare cellule fMC solo nei casi di pazienti con AR stabile o in fase di remissione. Infine, è stata esplorato il profilo epigenetico attraverso analisi di metilazione di LINE-1 e dei geni HLA-G e MTHFR, su soggetti sani di controllo, su pazienti con artrite agli esordi e su pazienti con diagnosi accertata di AR. HLA-G ha evidenziato una significativa ipermetilazione nelle pazienti donne con AR rispetto agli uomini; mentre MTHFR ha rivelato una significativa ipometilazione, gradualmente maggiore a seconda della progressione di AR. In conclusione, i risultati esposti nella presente tesi hanno evidenziato il network di interazioni come importante elemento causativo di insorgenza e risposta terapeutica di AR. Inoltre, il focus sulle pazienti donne affette da AR ha enfatizzato l'applicazione della medicina di genere; infine, lo studio di epigenetica è il primo ad indagare lo stato di metilazione e la progressione di AR, sottolineando l'importanza del contributo ambientale e consentendo una nuova direzione esplorativa.
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Riding, S. Barbara. « The arthritic pain experience of children with juvenile rheumatoid arthritis ». Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27731.
Texte intégralRésumé :
This study was designed to investigate the experience of having arthritic pain from the children's perspective. Previous research on how Canadian children perceive and manage arthritic pain and how it affects their daily lives is nonexistent. Therefore the purpose of this qualitative descriptive study was to explore and describe the arthritic pain experience of school age children with juvenile rheumatoid arthritis (JRA) and to understand the impact/influence of various factors on the construction of that experience.
Ten children, aged 10 to 13 years, with either early (at 2 to 4 years) or late (at 7 to 11 years) onset arthritis participated in this study. Descriptive data were obtained during two open-ended in depth interviews with the children in their homes. Using content analysis, data were analyzed for themes and their elements. An analytical framework of themes and their elements was developed that reflected the children's descriptions of and explanations for arthritic pain in the context of their day to day in the context of their day to day living with arthritis, both in the past and currently.
The children perceived pain to be synonymous with arthritis and the mediating factor in how they functioned. They described arthritic pain in relation to distinguishing factors: intensity, duration, and frequency. Intermittent arthritic pain was attributed to cessation of medications, arthritis "flare-ups," inactivity, and activity. A current concern for most children was pain attributed to activity because it meant limitations in activities with peers. The children identified strategies they used to manage pain and cope with pain's unpredictability.
The findings of this study were discussed in relation to selected research studies that either supported or refuted the findings of this study. Implications for nursing practice and research were addressed.Applied Science, Faculty of
Nursing, School of
Graduate
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MAZZONI, MARTA. « VALORE PREDITTIVO DELL’ECOGRAFIA MUSCOLOSCHELETRICA NEI PAZIENTI AFFETTI DA ARTRITE IDIOPATICA GIOVANILE IN REMISSIONE CLINICA ». Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1046998.
Texte intégralRésumé :
Background: the accurate assessment of remission status in JIA patients is of utmost relevance to taper medications and prevent side effects from their long-term administration. In RA patients in clinical remission (CR), musculoskeletal ultrasound (MSUS) allows to detect persistent joint inflammation (subclinical synovitis), which predicts disease flare and structural damage progression. Although subclinical synovitis has been reported in a substantial proportion of JIA patients with inactive disease, its prognostic value is still being defined.
Objectives: 1) to investigate the prevalence of MSUS-detected subclinical synovitis in JIA patients in CR; 2) to establish which and how many joints should be scanned to reliably assess remission; 3) to evaluate the persistence of subclinical synovitis over the time; 4) to investigate whether subclinical synovitis entails a risk of disease flare and whether it should affect the therapeutic strategy.
Methods: 135 consecutive JIA patients who met the Wallace criteria for CR were included in this 3-years prospective study. All patients underwent MSUS assessment of 56 joints at study entry and at 6 months follow-up visit. Joints were scanned for synovial hyperplasia, joint effusion and Power Doppler (PD) signal by two independent ultrasonographers. Patients were followed clinically for 3 years. A flare of synovitis was defined as a recurrence of clinically active arthritis. The association between clinical and MSUS variables with flare, was evaluated by adjusted logistic regression models.
Results: 135 patients (78.5% F; median age 11.3 y; median disease duration 5.7 y; median CR duration 1.4 y) were included. Fifty-seven/135 (42.2%) patients had persistent oligoarthiritis; 41/135 (30.4%) extended oligoarthiritis; 32/135 (23.7%) polyarthiritis; 5/135 (3.7%) systemic arthritis. Seventy-eight/135 (57.7%) patients were in CR on medication. Subclinical synovitis was detected in 32/135 (23.7%) patients and in 53/7560 (0.7%) joints. Subclinical tenosynovitis was present in 20/135 (14.8%) patients. Subclinical synovitis was found more frequently in the ankle and wrist joints. 58.6% of patients showed persistent subclinical synovitis at 6 month follow up MSUS examination. During the 3-year follow up 45/135 (33.3%) patients experienced a disease flare (median survival time 2.2 y). PD positivity in tendons was the stronger independent risk factor of flare on multivariable regression analysis (HR: 4.8; P=0.04). Other predictors of flare were the JIA subtype (oligo-extended form: HR: 2.3; P=0.031) and the status of CR on medication (HR: 3.7; P=0.002).
Conclusion: our results confirm that MSUS is more sensitive than clinical evaluation in the assessment of persistent synovial inflammation in JIA patients. Subclinical tenosynovitis was the best predictor of disease flare. To date, the role of tenosynovitis in the diagnosis and prognosis of JIA has been poorly investigated. Our results further support the role of MSUS, especially of the wrist and the ankle, in monitoring JIA patients in clinical remission and to predict disease flare.
References:
De Lucia O, et al. Baseline ultrasound examination as possible predictor of relapse in patients affected by juvenile idiopathic arthritis (JIA). Ann Rheum Dis. 2018 Oct;77(10):1426-1431.
Filippou G, et al. The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STARTER study. Ann Rheum Dis 2018;77:1283-9.
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Soula, P. Ch Eugène. « Contribution à l'étude de la migraine ». Paris : BIUM, 2004. http://www.bium.univ-paris5.fr/histmed/medica/cote?TPAR1884x035.
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ZANETTI, ANNA. « The management of patients with rheumatoid arthritis : an overview of obstacles and improvement strategies ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/365542.
Texte intégralRésumé :
L’artirite reumatoide (AR) è la più diffusa patologia autoimmune in Italia con elevati costi terapeutici e previdenziali associati. Questa patologia colpisce circa lo 0.5-1% della popolazione adulta, prevalentemente di genere femminile. Essendo una patologia degenerativa, i cui danni sono frequentemente irreversibili, una diagnosi precoce così come un adeguato trattamento ed un elevato livello di compliance del paziente allo stesso, potrebbero rallentare il peggioramento della malattia. Inoltre sono poco noti i possibili effetti della malattia e del suo trattamento sulle gravidanze e i successivi outcome gravidici. I principali obiettivi della tesi quindi sono: i) valutare l’aderenza alle linee guida per il trattamento dell’ AR da parte dei clinici, ii) valutare l’aderenza al trattamento per AR da parte del paziente, iii) stimare costo ed efficacia delle cure erogate nelle cliniche specializzate per il trattamento di pazienti con AR, iv) analizzare gli esiti gravidici e il raggiungimento della gravidanza in donne con AR trattate con metotrexate (MTX). La prima tematica ha riguardato la valutazione di come sono state implementate le linee guida della European Alliance of Associations for Rheumatology (EULAR) per il trattamento dell’AR e l’impatto dell’aderenza a queste linee guida sulla probabilità di ospedalizzazione. I principali risultati di questo studio hanno mostrato come i pazienti con un’ottima aderenza alle linee guida, se confrontati con quelli con bassa aderenza, abbiano un rischio del 24% inferiore di incorrere in ospedalizzazione. La seconda tematica ha riguardato la valutazione dell’impatto dell’aderenza al trattamento con Disease-Modifying Anti-Rheumatic Drugs (DMARDs), terapia suggerita dall’EULAR, sul raggiungimento della remissione clinica di malattia. I dati provengono dal database ELECTRA (con informazioni cliniche e provenienti da database amministrativi) di pazienti con AR trattati presso l’IRCCS Policlinico San Matteo (Pavia). Si è osservato che un incremento percentuale di 10 unità nella copertura al trattamento comporta un aumento della probabilità di remissione clinica del 10%. Da questi risultati sembra emergere l’importanza di riuscire a monitorare i pazienti nella pratica clinica per mantenere elevati standard di compliance. L’obiettivo della terza tematica si è focalizzato su una valutazione costo-efficacia del trattamento dei pazienti con AR erogato da cliniche specializzate (EAC), confrontandolo con quello dei pazienti trattati in cliniche non specializzate. Sono state quindi reclutate due coorti, la prima di pazienti trattati in una EAC e l’altra estratta dai database amministrativi di regione lombardia tra i soli soggetti con AR. I risultati principali di questa terza fase hanno mostrato come ad un incremento moderato dei costi si associ un incremento molto elevato dell’efficacia, specialmente se calcolata come durata di degenza e come aderenza alle linee guida EULAR. La quarta ed ultima tematica riguarda l’analisi dell’impatto del trattamento con MTX (DMARD suggerito dall’EULAR come prima linea di trattamento) nelle pazienti con AR sulla possibilità di raggiungere una gravidanza e sugli outcome gravidici conseguenti. Sono state definite tre coorti: donne con AR con esposizione incidente di MTX, donne con AR senza trattamento con MTX e donne senza AR. I risultati principali di questa analisi hanno mostrato che le donne con AR, specialmente se trattate con MTX, hanno una minor frequenza di gravidanze rispetto alle donne senza AR. Inoltre, le donne trattate con MTX sembrano avere un rischio più elevato di aborto spontaneo (circa due volte superiore) rispetto alle altre due coorti.Rheumatoid arthritis (RA) is, in Italy, the most widespread autoimmune disease with high associated costs for the National Health Service. This disease affects about 0.5-1% of the adult population, mainly of the female gender. Being a degenerative disease, whose damages are frequently irreversible, an early diagnosis as well as an adequate treatment and a high level treatment compliance of the patient, could slow down the worsening of the disease. Furthermore, the possible effects of RA and its treatment on pregnancies and subsequent pregnancy outcomes are not well known. The main objectives of the thesis are therefore: i) to evaluate the adherence to guidelines for the treatment of RA, ii) to evaluate the patient's adherence to RA treatment, iii) to estimate the cost and effectiveness of care provided in specialized clinics for the treatment of RA patients, iv) to analyze pregnancy outcomes and the likelihood of achieving pregnancy in women with RA treated with methotrexate (MTX). The first issue concerned the assessment of how the guidelines of the European Alliance of Associations for Rheumatology (EULAR) for the treatment of RA have been implemented, and the impact of adherence to these guidelines on the probability of hospitalization. The main results of this study showed that patients with excellent adherence to guidelines, when compared with those with low adherence, have a 24% lower risk of hospitalization. The second topic concerned the evaluation of the impact of adherence to treatment with Disease-Modifying Anti-Rheumatic Drugs (DMARDs), the therapy suggested by EULAR, on the achievement of disease clinical remission (defined as a substantial decrease or absence of symptoms). The ELECTRA database, which contains clinical information and information from administrative databases of RA patients treated at the IRCCS Policlinico San Matteo (Pavia), was considered for the analysis. The main finding showed that a 10-unit percentage increase in proportion of days covered by DMARDs is associated with a 10% increase in the likelihood of clinical remission. These results show the importance of monitoring patients in clinical practice to maintain high levels of treatment compliance. The objective of the third theme focused on a cost-effectiveness evaluation, comparing RA patients treated in specialized clinics ("Early Arthritis Clinic" - EAC), with RA patients treated in non-specialized clinics. Two cohorts were recruited, the first one included patients treated in the EAC of the IRCCS Policlinico San Matteo and the other one with patients with RA extracted from the administrative databases of Lombardy region. The main results of this third phase showed that a moderate increase in costs is associated with a very high increase in effectiveness, especially if calculated as length of hospitalizations and as adherence to the EULAR guidelines. These findings could open up new scenarios in RA patient management. The fourth and final topic concerned the impact of treatment with MTX (DMARD suggested by EULAR as the first line of treatment) in RA women, on the likelihood of achieving pregnancy and on pregnancy outcomes. Three cohorts were recruited: women with RA with incident MTX exposure, women with RA without MTX treatment, and women without RA. The main results of this analysis showed that women with RA, especially when treated with MTX, have a lower frequency of pregnancies than women without RA. Furthermore, women treated with MTX have a higher risk of spontaneous abortion (about twice as high) than the other two cohorts.
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Cavaciocchi, F. « T CELL SUBTYPES IN MANAGEMENT OF OSTEOPOROSIS WITH BISPHOSPHONATES AND THE AUTOIMMUNE REACTION TO THE COLLAGEN IN RHEUMATOID ARTHRITIS ». Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/251417.
Texte intégralRésumé :
T lymphocytes with different T cell receptors are at the crossroad of inflammation and autoimmunity. We investigated the role of γδTCR and αβTCR T lymphocytes (γδT, αβT cells) in two model conditions represented by zoledronic acid (ZA)-induced acute phase reactions (APR) and in the immune reaction against collagen in rheumatoid arthritis (RA).
First, γδTCR T lymphocytes (γδTcells) are specifically activated by ZA infusion in the treatment of osteoporosis and is frequently associated with the onset of APR, possibly via 25-OH vitamin D (25-OHvD) levels. 50% of patients reported ZA-associated APR (APR+). APR+ cases had a higher percentage of central memory Th1-like γδTcells before treatment. One week after ZA infusion, a decreased percentage of central memory Th1-like γδTcells, an increase in the percentage and activation of effector memory Th1-like γδTcells, and an increase in Th17-like γδTcells were observed in the patients with APR. Lower 25-OHvD levels were significantly associated to APR, but no correlation was found between 25-OHvD level and γδTcell percentage or subsets. Second, αβTCR T lymphocytes (αβTcells) in RA recognize the DR4/DR1-restricted epitope 261-273 of the human type II collagen, whereas B cells recognize the epitope 359-369. We investigated the role of B and T cell epitopes and their post-translational modifications on the RA adaptive immune response. PBMCs from 5 HLA-DR4+ monozygotic twins, two HLA-DR4+ and one HLA-DR3+ healthy donor and synovial fluids (SF) from an HLA-DR4+ RA patient and HLA-DR3+ patient were used and cells cultured with the native form of the collagen T epitope (261-273T), its K264 carbamylated form (homocit261-273T), the native form of the collagen B epitope (359-369B), its R360 citrullinated form (cit359-369B) or the combination of the native and modified epitopes. We may conclude that the collagen T epitope 261-273 has a role in the pathogenesis of RA, but the carbamilation of this epitope dos not seem to be influent in the T cell response.
Livres sur le sujet "Arthriti"
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Canada, Canada Health, dir. Arthritis in Canada : An ongoing challenge. [Ottawa] : Health Canada, 2003.
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R, Starr Michael, dir. Arthrite, le guide complet. Montréal] : Caractère, 2013.
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Pawlotsky, Yves. Rhumatologie : Diagnostic et conduite thérapeutique. Paris : Ellipses, 1988.
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Les aliments contre l'arthrite et l'arthrose : 72 aliments antidouleur, 115 recettes gourmandes. Montréal : Éditions Cardinal, 2010.
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Ma cuisine contre l'arthrite : 72 aliments antidouleur, 115 recettes gourmandes. Montréal : Éditions Cardinal, 2007.
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Association, Canadian Medical, dir. Arthritis. 3e éd. Toronto : Key Porter Books, 2005.
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H, Klippel John, Weyand Cornelia M, Crofford Leslie J, Stone John H et Arthritis Foundation, dir. Primer on the rheumatic diseases. Atlanta, Ga : Arthritis Foundation, 2001.
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Paul, Dieppe, dir. Arthritis and rheumatism in practice. London : Gower Medical Pub., 1991.
Trouver le texte intégralChapitres de livres sur le sujet "Arthriti"
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Bhalla, Parinishtha, Anukriti Verma, Bhawna Rathi, Shivani Sharda et Pallavi Somvanshi. « Exploring Molecular Signatures in Spondyloarthritis : A Step Towards Early Diagnosis ». Dans Proceedings of the Conference BioSangam 2022 : Emerging Trends in Biotechnology (BIOSANGAM 2022), 142–55. Dordrecht : Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_15.
Texte intégralRésumé :
AbstractSpondyloarthritis is an acute inflammatory disorder of the musculoskeletal system often accompanied by pain, stiffness, bone and tissue damage. It majorly consists of ankylosing spondylitis, psoriatic arthritis and reactive arthritis. It follows a differential diagnosis pattern for demarcation between the spondyloarthritis subtypes and other arthritic subtypes such as rheumatoid arthritis, juvenile arthritis and osteoarthritis due to the heterogeneity causing gradual chronicity and complications. Presence of definite molecular markers can not only improve diagnosis efficiency but also aid in their prognosis and therapy. This study is an attempt to compose a refined list of such unique and common molecular signatures of the considered subtypes, by employing a reductionist approach amalgamating gene retrieval, protein-protein interaction network, functional, pathway, micro-RNA-gene and transcription factor-gene regulatory network analysis. Gene retrieval and protein-protein interaction network analysis resulted in unique and common interacting genes of arthritis subtypes. Functional annotation and pathway analysis found vital functions and pathways unique and common in arthritis subtypes. Furthermore, miRNA-gene and transcription factor-gene interaction networks retrieved unique and common miRNA’s and transcription factors in arthritis subtypes. Furthermore, the study identified important signatures of arthritis subtypes that can serve as markers assisting in prognosis, early diagnosis and personalized treatment of arthritis patients requiring validation via prospective experimental studies.
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Order, Stanley E., et Sarah S. Donaldson. « Arthritis ». Dans Radiation Therapy of Benign Diseases, 38. Berlin, Heidelberg : Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-58719-1_19.
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Ash, Zoe, Sibel Zehra Aydin, Ai Lyn Tan et Dennis McGonagle. « Arthritis ». Dans Nail Psoriasis, 33–42. Cham : Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-08810-5_5.
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Gilbert, Patricia. « Arthritis ». Dans The A-Z Reference Book of Childhood Conditions, 16–21. Boston, MA : Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-7098-5_5.
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Viegas, Steven F. « Arthritis ». Dans Hand Surgery Study Guide, 93–101. New York, NY : Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-1910-1_10.
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Kuchynski, Marie. « Arthritis ». Dans Encyclopedia of Women’s Health, 112–14. Boston, MA : Springer US, 2004. http://dx.doi.org/10.1007/978-0-306-48113-0_38.
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Bährle-Rapp, Marina. « Arthritis ». Dans Springer Lexikon Kosmetik und Körperpflege, 48. Berlin, Heidelberg : Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_823.
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O’Connor, Philip James, J. Farrant, Richard Hodgson, Kay-Geert A. Hermann, Nathalie Boutry, Xavier Demondion, Chadi Khalil et al. « Arthritis ». Dans Measurements in Musculoskeletal Radiology, 719–84. Berlin, Heidelberg : Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-540-68897-6_18.
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Schroeder, Beth. « Arthritis ». Dans Encyclopedia of Behavioral Medicine, 151–52. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_1629.
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Abrams, David B., J. Rick Turner, Linda C. Baumann, Alyssa Karel, Susan E. Collins, Katie Witkiewitz, Terry Fulmer et al. « Arthritis ». Dans Encyclopedia of Behavioral Medicine, 128–29. New York, NY : Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_1629.
Texte intégralActes de conférences sur le sujet "Arthriti"
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Baer, Thomas, Ryan Frisbie, Michael Willey et Jessica Goetz. « Development of a Simplified Ankle Distractor ». Dans 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3438.
Texte intégralRésumé :
The physical impairment caused by OA of a single lower extremity joint is comparable to that reported for major life-altering disorders such as end-stage kidney disease and heart failure. (Buckwalter, et al) [1] Ankle distraction arthroplasty has been shown to greatly decrease pain due to end-stage ankle arthritis. Unlike arthrodesis (fusion of the joint), distraction arthroplasty maintains the joint’s natural movement, and it is far less complicated than total joint replacement surgery. There is a considerable body of research supporting the idea that distraction of an end-stage arthritic joint (most of the work thus far has been done on ankles, although there has also been some investigation of the efficacy of the treatment for knee arthritis) for a period of weeks allows the growth of new tissue in the joint. Although this tissue is not true articular cartilage, distraction arthroplasty has been shown to significantly decrease pain and, in the majority of cases, to be a long lasting remedy for a condition that would otherwise commonly be treated with arthrodesis. [2] Devices currently available for this procedure are generally quite complicated because they are designed for a wide range of functions related to bone fixation. This versatility also tends to make those systems larger and more expensive, and their aggressively mechanical appearance makes potential joint distraction patients hesitant to select the procedure. While fracture patients may not have a choice about being treated with such devices, elective patients are instinctively resistant to their use, even when assured that the end result will most likely significantly improve in the quality of their lives.
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Chen, Xi, et Fan Li. « Effects of Arthrigia on adjuvant arthritis rats' serum TNF-α ; ». Dans 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6027993.
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Waller, Alexander J., Terence E. McIff, Mehmet Bilgen, E. Bruce Toby et Kenneth J. Fischer. « Validation of MRI-Based Contact Modeling for Analysis of In Vivo Radiocarpal Mechanics ». Dans ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176741.
Texte intégralRésumé :
Arthritis is a pervasive problem and over 15% of the total population of the United States has been doctor-diagnosed with arthritis. Even more Americans have symptoms. Clearly, understanding the pathogenesis of arthritis, developing effective treatments and/or finding ways to prevent it are all important goals.
4
YAMAUCHI, Morio, Kazuhisa NAKANO, Yoshiya TANAKA et Keiichi HORIO. « Predicting Disease Activity for Biologic Selection in Rheumatoid Arthritis ». Dans 9th International Conference on Signal, Image Processing and Pattern Recognition (SPPR 2020). AIRCC Publishing Corporation, 2020. http://dx.doi.org/10.5121/csit.2020.101913.
Texte intégralRésumé :
In this article, we implemented a regression model and conducted experiments for predicting disease activity using data from 1929 rheumatoid arthritis patients to assist in the selection of biologics for rheumatoid arthritis. On modelling, the missing variables in the data were completed by three different methods, mean value, self-organizing map and random value. Experimental results showed that the prediction error of the regression model was large regardless of the missing completion method, making it difficult to predict the prognosis of rheumatoid arthritis patients.
5
Fischer, Kenneth J., Alexander J. Waller, Mehmet Bilgen, E. Bruce Toby, Manuela Kunz, Terence E. McIff et Felix Eckstein. « Cartilage Deformation Measured by MRI Image Segmentation Validates MRI-Based Modeling Results ». Dans ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193037.
Texte intégralRésumé :
The onset of arthritis is clearly associated with abnormal joint kinematics and contact pressures [1]. Yet our understanding of in vivo joint mechanics is still limited. In order to elucidate the relationship between joint mechanics and arthritis we must increase our knowledge of normal contact pressure distributions that help maintain healthy cartilage and abnormal contact pressure distributions that lead to arthritis. MRI-based modeling is a non-invasive means of determining joint mechanics in vivo, by combining information from MRI scans of joints with and without active functional loading.
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SUN, YANG-BO, et ZHI-LI ZENG. « BIBLIOMETRIC ANALYSIS OF METHOTREXATE IN THE TREATMENT OF RHEUMATOID ARTHRITIS ». Dans 2021 International Conference on Education, Humanity and Language, Art. Destech Publications, Inc., 2021. http://dx.doi.org/10.12783/dtssehs/ehla2021/35713.
Texte intégralRésumé :
[Objective] To analyze the growth rule of literature, core authors, core institutions and Co-word Analysis in the field of methotrexate in the treatment of rheumatoid arthritis, to draw the knowledge map of key words and the cooperation network of authors, and to get the current frontiers and research hotspots through the research and analysis of these indicators, so as to provide reference for future researchers to choose research directions. [Methods] The three databases including CNKI, Wanfangdata and Cqvip were used as retrieval databases, and the key words of "rheumatoid arthritis" and "methotrexate" and their synonyms were used as retrieval keywords. The literature published in the three databases from 2009 to 2018 were retrieved and analyzed by bibliometrics analysis method. [Result] 2404 valid literature were screened out. The growth curve of literature showed a relatively stable upward trend, and formed a stable core group of high-yield authors. The main direction of research in this field in the past ten years was the effectiveness analysis of methotrexate combined with drug treatment for rheumatoid arthritis. [Conclusion] Domestic research on methotrexate in the treatment of rheumatoid arthritis will continue to be the focus of medical research in the next few years. Rheumatoid arthritis (RA) is a chronic systemic immune disease. Its early manifestations are mainly joint pain and dysfunction. It can lead to joint function loss and accompanied by atrophy of bone and skeletal muscle. It has a high disability rate and seriously threatens human physical and mental health [1].The incidence of rheumatoid arthritis was higher in women than in men [2]. According to statistics, the prevalence of rheumatoid arthritis in China is between 0.32% and 0.36% [3]. Therefore, searching for drugs with less side effects and obvious effects is a research hotspot in the medical field [4]. Methotrexate, as a gold standard antirheumatic drug, has been widely used in combination therapy and randomized controlled clinical trials [5]. In order to clearly understand the research and development trend of methotrexate in the field of rheumatoid arthritis, this paper makes bibliometric analysis of the relevant literature published in this field in the past 10 years, and provides reference for the future research and development of this field with objective and real data.
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Kaurova, A. V., I. V. Puhteeva, L. A. Malkevich et N. V. Gerasimovich. « ANALYSIS OF CALCIUM IONS IN THE CYTOPLASM OF PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH RHEUMATOID ARTHRITIS ». Dans SAKHAROV READINGS 2021 : ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-262-265.
Texte intégralRésumé :
The paper analyzes the content of calcium ions in the cytoplasm of peripheral blood lymphocytes in patients with rheumatoid arthritis. It has been shown that there is an increase in the concentration of intracellular ionized calcium in patients with rheumatoid arthritis relative to the control group, which history does not contain information about this disease.
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Mercer, Deana, Christina Salas, James Love, Letitia Lansing, Amanda Medoro, Mahmoud M. Reda Taha et Tahseen Cheema. « Simulated Osteotomy of the Trapezium Reduces Radial Subluxation and Improves Contact Pressure Distribution Across the Thumb Carpometacarpal Joint in Lateral Pinch ». Dans ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19609.
Texte intégralRésumé :
Joint laxity and radial subluxation of the metacarpal on the trapezium have been associated with arthritis of the carpometacarpal (CMC) joint of the thumb. In normal flexion and extension of the thumb, the ligaments and the joint are minimally stressed. However, in opposition and lateral pinch (key pinch), the two surfaces rotate on each other, generating an unequal surface stress. Over time, the unequal stresses lead to an asymmetrical wear pattern. This leads to increased strain on the ligaments and may lead to subluxation over time.1 Surgical treatment of early arthritis of the CMC joint includes ligament reconstruction or first metacarpal extension osteotomy to decrease joint laxity. Once laxity exists, joint degeneration is accelerated.2 The long-term impact of painful CMC arthritis on activities of daily living can be debilitating.
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Yildirim, Pinar. « Mining Online Drug Reviews Database for the Treatment of Rheumatoid Arthritis by using Deep Learning ». Dans 3rd International Conference on Data Science and Machine Learning (DSML 2022). Academy and Industry Research Collaboration Center (AIRCC), 2022. http://dx.doi.org/10.5121/csit.2022.121509.
Texte intégralRésumé :
In this paper, a research study for online patient reviews is introduced. Rheumatoid arthritis is a long-term and disabling autoimmune disease. Today, a huge amount of people have rheumatoid arthritis in the world. Considering the importance of the medication of rheumatoid arthritis, we aimed to investigate patient reviews in WebMD database and get some useful information for this disease. Our results revealed that etanercept treatment has the highest number of reviews. Data analysis was applied to discover knowledge on this drug. Deep learning approach was used to predict the effectiveness of etanercept and classification results were compared with other traditional classifiers. According to the comparison of classifiers, deep neural network has better accuracy metrics than others. Therefore, the results highlight that deep learning can be encouraging for medical data analyses. We hope that our study can make contributions to intelligent data analysis in medical domain.
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Pal, S., B. Kundu et M. S. Ghosh. « Electrical Characterisation of Normal and Pathological Synovial Fluid in Arthritis ». Dans ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0287.
Texte intégralRésumé :
Abstract Arthritis is a very painful and crippling disease, affecting almost 12–13% of the World population alone in the age group of 40 to 60 years, resulting out of the degeneration of the active lubricant synovial fluid (S.F.)[1]. The motivation of the present study is to investigate the electrical behaviours of synovial fluid in normal and different forms of arthritis; elaborate work has already been carried out on the rheological and biochemical properties of synovia but relatively very little has been reflected upon its electrical behaviour. It is believed that the rheological deterioration could show some changes in the electrical characteristics of this polar biofluid too.
Rapports d'organisations sur le sujet "Arthriti"
1
Chen, Cheng-Che, et Chung-Jen Chen. New-Onset Inflammatory Arthritis After Covid-19 Vaccination. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, juillet 2022. http://dx.doi.org/10.37766/inplasy2022.7.0128.
Texte intégralRésumé :
Review question / Objective: Investigate the new-onset inflammatory arthritis after Covid-19 vaccination in patients without pre-existing autoimmune nor rheumatic diseases and analyze their clinical patterns. Condition being studied: To help the readers to understand the clinical patterns of new-onset inflammatory arthritis after Covid-19 vaccination in patients without pre-existing autoimmune nor rheumatic diseases. Eligibility criteria: Inclusion criteria: publications of new-onset inflammatory arthritis after Covid-19 vaccination in patients without pre-existing autoimmune nor rheumatic diseases between January 2020 to March 2022. Exclusion criteria: cases with arthritis after SARS-CoV-2 infection and arthritis reactivation in those with underlying or history of arthritis-associated or autoimmune diseases.
2
Kalinina, E. V., A. R. Babaeva, A. V. Levickaya et M. S. Zvonorencko. MULTIMORBIDITY IN RHEUMATOID ARTHRITIS. Планета, 2018. http://dx.doi.org/10.18411/978-5-907109-24-7-2018-xxxv-184-186.
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Russell, Mark, James Galloway, Sumera Qureshi, Joanna Ledingham, Arti Mahto, Andrew Rutherford, Maryam Adas et al. Incidence and management of inflammatory arthritis in England before and during the COVID-19 pandemic. OpenSAFELY, janvier 2023. http://dx.doi.org/10.53764/rpt.ca5bce7991.
Texte intégralRésumé :
The National Early Inflammatory Arthritis Audit (NEIAA) is the largest audit of its kind globally, reporting on care delivered across rheumatology services in the NHS in England. Clinical researchers from King’s College London are collaborating with OpenSAFELY to recreate key aspects of NEIAA, and benchmark the quality of care for people with inflammatory arthritis in England. This report will be updated on a regular basis.
4
Fox, David A. Citrullinated Chemokines in Rheumatoid Arthritis. Fort Belvoir, VA : Defense Technical Information Center, octobre 2014. http://dx.doi.org/10.21236/ada611994.
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Cockburn, Iain, et Aslam Anis. Hedonic Analysis of Arthritis Drugs. Cambridge, MA : National Bureau of Economic Research, mai 1998. http://dx.doi.org/10.3386/w6574.
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Kalinina, E. V., E. V. Krivospitskaya, A. R. Babaeva et M. S. Zvonorenko. COMORBIDITY IN PATIENTS WITH RHEUMATOID ARTHRITIS. "PLANET", 2019. http://dx.doi.org/10.18411/978-5-907192-54-6-2019-xxxvi-112-119.
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Deane, Keivn D. Pathogenesis and Prediction of Future Rheumatoid Arthritis. Fort Belvoir, VA : Defense Technical Information Center, octobre 2014. http://dx.doi.org/10.21236/ada613196.
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Zhigulina, K. V., et S. S. Spitsina. Carbohydrate imbalance in patients with gouty arthritis. DOI CODE, 2021. http://dx.doi.org/10.18411/wco-iof-esceo-2021-392-2.
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Author, Not Given. Discovery and Development of Novel Anti-Arthritic Agents. Office of Scientific and Technical Information (OSTI), septembre 2009. http://dx.doi.org/10.2172/971998.
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Mozgovaya, E. E., A. S. Trofimenko, M. A. Mamus, E. A. Tikhomirova, S. A. Bedina et S. S. Spitsma. FORMATION OF MONOCYTE EXTRACELLULAR TRAPS IN RHEUMATOID ARTHRITIS. Academy of Natural Knowledge, 2019. http://dx.doi.org/10.18411/1996-3955-2019-10-86-89.
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