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Articles de revues sur le sujet « Auditory pathways – Effect of drugs on »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 1 février 2022

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1

Cevette, Michael J., Kay B. Franz, Robert H. Brey, and Martin S. Robinette. "Influence of Dietary Magnesium on the Amplitude of Wave V of the Auditory Brainstem Response." Otolaryngology–Head and Neck Surgery 101, no. 5 (1989): 537–41. http://dx.doi.org/10.1177/019459988910100504.

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Thirty-six weanling guinea pigs were fed either a low (600 ppm) or normal (3000 ppm) diet of magnesium for 8 weeks. One half of each diet group received intramuscular injections of magnesium-depleting drugs, furosemide and gentamicin. The other half were controls and received equal intramuscular injections of saline. Auditory brainstem responses were obtained from all animals before and after 8 weeks of treatment of diet and drugs to examine the effects of treatment upon hearing and auditory brainstem function. A three-way analysis of variance of dietary magnesium, by drug and by sex, showed n

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Lee, Jaime, Shane Thwaites, Andrea Gogos, and Maarten van den Buuse. "Pharmacological Mechanisms Involved in Sensory Gating Disruption Induced by (±)-3,4-Methylene- Dioxymethamphetamine (MDMA): Relevance to Schizophrenia." Brain Sciences 10, no. 1 (2020): 44. http://dx.doi.org/10.3390/brainsci10010044.

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Sensory gating deficits have been demonstrated in schizophrenia, but the mechanisms involved remain unclear. In the present study, we used disruption of paired-pulse gating of evoked potentials in rats by the administration of (±)-3,4-methylene-dioxymethamphetamine (MDMA) to study serotonergic and dopaminergic mechanisms involved in auditory sensory gating deficits. Male Sprague-Dawley rats were instrumented with cortical surface electrodes to record evoked potential changes in response to pairs of 85dB tones (S1 and S2), 500msec apart. Administration of MDMA eliminated the normal reduction in

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Zhang, Dejun, Guofang Guan, Yingyuan Guo, Yanru Hao, Fang Guo, and Zeming Fu. "Protective effect of ethosuximide on hearing in NOD/LtJ mice via blockage of endogenous apoptosis." Tropical Journal of Pharmaceutical Research 19, no. 2 (2020): 299–304. http://dx.doi.org/10.4314/tjpr.v19i2.12.

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Purpose: To determine the protective effect of ethosuximide on the hearing of NOD/LtJ mice, and the underlying mechanism of action. Methods: The mice were randomly assigned to control and treatment groups (20 mice per group). Mice in the treatment group were administered ethosuximide intraperitoneally at a dose of 200mg/kg body weight (bwt), while those in the control group received an equivalent dose of saline via the same route. Both groups were subjected to auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) tests, as well as determination of mRNA ex

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Ojimba, Chiedozie, Ayotomide Oyelakin, and Taher Khandaker. "Accidental Overdose of Paliperidone Palmitate." Case Reports in Psychiatry 2019 (April 11, 2019): 1–3. http://dx.doi.org/10.1155/2019/7406298.

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Long-acting injectable (LAI) antipsychotics first introduced in 1960s are useful in the treatment of schizophrenic patients with poor medication adherence due to their maintaining feature of therapeutic plasma level without daily administration. Paliperidone Palmitate is one of such LAI antipsychotic drugs used due to its benefit of maintaining a therapeutic plasma level with four-week interval of injections. We report the case of a 21-year-old male with a history of mental illness that presented with selective mutism, disorganized speech, thought process and behavior, and auditory hallucinati

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Gauvin, David V., Joshua D. Yoder, Rachel L. Tapp, and Theodore J. Baird. "Small Compartment Toxicity." International Journal of Toxicology 36, no. 1 (2016): 8–20. http://dx.doi.org/10.1177/1091581816648905.

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Life experiences, industrial/environmental exposures, and administration of Food and Drug Administration (FDA)-approved drugs may have unintended but detrimental effects on peripheral and central auditory pathways. Most relevant to the readership of this journal is the role that drug treatments approved by the FDA as safe and effective appear to interact with 3 independent modes of toxicity within the small compartment of the ear. What may seem to be trivial drug-induced toxicity has the potential to change important measures of quality of life and functional capacity of mid- to late-life pati

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Di Maria, Domenico. "New therapeutic approach with ozoile® to the EAC eczema, a chronic and annoying pathology." Journal of Otolaryngology-ENT Research 12, no. 1 (2020): 32–35. http://dx.doi.org/10.15406/joentr.2020.12.00452.

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The Eczema of the external auditory canal (EAC) is a challenge for the otolaryngologist and it’s a pathology that can annoy the patients and, in the most extreme cases, compromise their quality of life. Hence patients with eczema of EAC are exposed to a greater number of bacterial (acute bacterial otitis externa) or fungal (otomycosis) infections. The therapies proposed as of now for chronic eczematous external otitis (more than 3 months) are empirical. The most widely used drugs in this condition are topical corticosteroids which unfortunately can lead to dehydration of the skin, hypotropism

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Gómez, Joaquín Guerra, and Jesús Devesa. "Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration." International Journal of Molecular Sciences 22, no. 6 (2021): 2829. http://dx.doi.org/10.3390/ijms22062829.

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Growth hormone (GH) plays an important role in auditory development during the embryonic stage. Exogenous agents such as sound, noise, drugs or trauma, can induce the release of this hormone to perform a protective function and stimulate other mediators that protect the auditory pathway. In addition, GH deficiency conditions hearing loss or central auditory processing disorders. There are promising animal studies that reflect a possible regenerative role when exogenous GH is used in hearing impairments, demonstrated in in vivo and in vitro studies, and also, even a few studies show beneficial

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Kim, Ye-Ri, Jeong-Mi Do, Kyung Hee Kim, et al. "C-phycocyanin from Limnothrix Species KNUA002 Alleviates Cisplatin-Induced Ototoxicity by Blocking the Mitochondrial Apoptotic Pathway in Auditory Cells." Marine Drugs 17, no. 4 (2019): 235. http://dx.doi.org/10.3390/md17040235.

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Ototoxicity, or adverse pharmacological effects on the inner ear or auditory nerve, is a common side effect of cisplatin, a platinum-based drug widely used in anticancer chemotherapy. Although the incidence of ototoxicity is high among patients that receive cisplatin therapy, there is currently no effective treatment for it. The generation of excessive reactive oxygen species (ROS) is considered to be the major cause of cisplatin-induced ototoxicity. C-phycocyanin (C-PC), a blue phycobiliprotein found in cyanobacteria and red algae, has antioxidant and anticancer activities in different experi

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Low, W. K., R. Burgess, K. W. Fong, and D. Y. Wang. "Effect of Radiotherapy on Retro-Cochlear Auditory Pathways." Laryngoscope 115, no. 10 (2005): 1823–26. http://dx.doi.org/10.1097/01.mlg.0000175061.59315.58.

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Dixit, Abhinav. "Effect of nicotine on auditory pathways: An unexplored domain." Indian Journal of Medical Specialities 6, no. 4 (2015): 134–35. http://dx.doi.org/10.1016/j.injms.2015.10.002.

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Dixit, Abhinav, Neelam Vaney, and O. P. Tandon. "Effect of caffeine on central auditory pathways: An evoked potential study." Hearing Research 220, no. 1-2 (2006): 61–66. http://dx.doi.org/10.1016/j.heares.2006.06.017.

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Prasher, Deepak. "Differential effect of adaptation on the ipsi- and contralateral auditory brainstem pathways." Scandinavian Audiology 24, no. 2 (1995): 101–5. http://dx.doi.org/10.3109/01050399509047522.

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Wang, Zhi, and Li Liou. "Auditory Effect of Kanamycin Given to Newborn Guinea Pigs Whose Mothers Received Kanamycin during Pregnancy." Annals of Otology, Rhinology & Laryngology 103, no. 12 (1994): 983–85. http://dx.doi.org/10.1177/000348949410301209.

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Clinical and experimental data indicate that aminoglycoside ototoxicity occurs more frequently in individuals previously exposed to ototoxic drugs. This study investigated the auditory effect of repetitive administration of kanamycin on newborn guinea pigs that had previously been exposed, in utero, to kanamycin administered to their mothers. Sixteen pregnant guinea pigs in the late stages of gestation were divided into two groups, one receiving kanamycin 500 mg/kg per day intramuscularly for 8 days, and the other acting as a control. After birth, the mothers and their newborns in both groups

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Hosseinzadeh, Azam, Seyed Kamran Kamrava, Brian C. J. Moore, et al. "Molecular Aspects of Melatonin Treatment in Tinnitus: A Review." Current Drug Targets 20, no. 11 (2019): 1112–28. http://dx.doi.org/10.2174/1389450120666190319162147.

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Tinnitus is a hearing disorder characterized by the perception of sound without external acoustic stimuli, which is caused by damage to the auditory system in response to excessive levels of noise, ototoxic agents and aging. Neural plasticity, oxidative/nitrosative stress and apoptosis play important roles in the pathogenesis of tinnitus. The expression of neural plasticity related to excessive glutamatergic neurotransmission leads to generation of abnormal sound in one&#039;s ears or head. Furthermore, hyperactivation and over-expression of NMDA receptors in response to excessive release

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Mehta, Rupali, Naren Kurmi, Manjinder Kaur, and Anjana Verma. "Effect of pregnancy on the auditory and visual reaction time." International Journal of Research in Medical Sciences 5, no. 2 (2017): 525. http://dx.doi.org/10.18203/2320-6012.ijrms20170144.

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Background: The auditory and visual pathways are complex multi-synaptic neuronal circuits prone to alteration in conductivity under the influence of various neuro-hormonal modulators. The female sex steroids have shown significant effect on these circuits during different phases on menstrual cycle and pregnancy.Methods: The present study was designed with an aim to find out the auditory and visual reaction time variations during different trimesters of pregnancy. The healthy non pregnant women, in premenstrual phase were grouped as controls (Group NP; n=30) whereas the cases were further divid

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Nishihara, K., T. Shimizu, H. Kotaki, et al. "Lack of effect of vancomycin and gentamicin on auditory function in guinea pigs." Antimicrobial Agents and Chemotherapy 40, no. 5 (1996): 1098–103. http://dx.doi.org/10.1128/aac.40.5.1098.

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The dispositions of vancomycin (VCM) and gentamicin (GM) in plasma and perilymph after single and multiple administrations and the effects of multiple administrations of VCM or GM alone and the combination of both drugs on auditory function were studied in male guinea pigs. The pharmacokinetic parameters of VCM and GM obtained from plasma drug concentration-time data after single and multiple (22 days) intramuscular administrations of VCM (200 mg/kg of body weight) alone and GM (50 mg/kg) alone were not significantly different from those after combined administration of VCM (200 mg/kg) and GM

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Sharma, Anu, and Michael F. Dorman. "The Effect of Age of Cochlear Implantation on the Development of Central Auditory Pathways." Perspectives on Hearing and Hearing Disorders Research and Diagnostics 6, no. 2 (2002): 5. http://dx.doi.org/10.1044/hhd6.2.5.

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DiSogra, Robert M., and Jerry Meece. "Auditory and Vestibular Side Effects of FDA-Approved Drugs for Diabetes." Seminars in Hearing 40, no. 04 (2019): 315–26. http://dx.doi.org/10.1055/s-0039-1697645.

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AbstractAs of September 10, 2019, there were 75 medications (oral/injectable/inhalants) approved by the U.S. Food and Drug Administration for diabetes management: 1 inhalant, 21 oral combinations, 22 injectable, and 31 oral medications (not in combination with any other diabetes drug). This article isolates the auditory and vestibular side effects of those drugs as reported by the drug's manufacturer as well as those side effects that could interfere with a balance assessment. Twenty of the 75 approved medications (26%) could have an auditory-related side effect. Hearing loss and tinnitus are

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Gemechu, Yohannes, David Millrine, Shigeru Hashimoto, et al. "Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs." Proceedings of the National Academy of Sciences 115, no. 46 (2018): 11802–7. http://dx.doi.org/10.1073/pnas.1814446115.

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Immunomodulatory drugs (IMiDs), including thalidomide derivatives such as lenalidomide and pomalidomide, offer therapeutic benefit in several hematopoietic malignancies and autoimmune/inflammatory diseases. However, it is difficult to study the IMiD mechanism of action in murine disease models because murine cereblon (CRBN), the substrate receptor for IMiD action, is resistant to some of IMiDs therapeutic effects. To overcome this difficulty, we generated humanized cereblon (CRBNI391V) mice thereby providing an animal model to unravel complex mechanisms of action in a murine physiological setu

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Minhas, Ravinder, Dhanashree Iyengar, Jagdeep Thakur, and Ramesh Azad. "Effect of HIV and Antiretroviral Treatment on Auditory Functions." International Archives of Otorhinolaryngology 22, no. 04 (2018): 378–81. http://dx.doi.org/10.1055/s-0038-1639594.

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Introduction Numerous studies have evaluated auditory functions in human immunodeficiency virus (HIV) patients; however, these studies had a few major limitations in terms of methodology as they used mainly evoked audiometry although this method is expensive, time consuming and not widely available. Therefore, we conducted a study in naïve HIV subjects with routine audiometry. Objective To determine the effect of HIV and of the drugs used to treat it on the auditory functions. Methods A prospective observational study was conducted in a medical college with 25 naive HIV-seropositive patients f

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Chen, Y. J., C. S. Liou, C. H. Tsai, and T. F. Yeh. "Effect of aminophylline on brain stem auditory evoked potentials in preterm infants." Archives of Disease in Childhood - Fetal and Neonatal Edition 71, no. 1 (1994): F20—F23. http://dx.doi.org/10.1136/fn.71.1.f20.

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To determine the neurophysiological effects of aminophylline on apnoea of prematurity, the brain stem auditory evoked potentials (BAEPs) of 30 apnoeic infants and 34 age matched controls were evaluated and compared. After six days of treatment with aminophylline, the brain stem conduction time (interpeak latency of I-V) in apnoeic infants decreased compared with controls of a similar postconceptional age. The mean latencies of the peaks and interpeaks of all waves except wave I were significantly lower in the apnoeic infants after than before receiving aminophylline. No significant differences

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Dalebout, Susan D., Nickola W. Nelson, Paul J. Hletko, and Barbara Frentheway. "Selective Auditory Attention and Children With Attention-Deficit Hyperactivity Disorder." Language, Speech, and Hearing Services in Schools 22, no. 4 (1991): 219–27. http://dx.doi.org/10.1044/0161-1461.2204.219.

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The Selective Auditory Attention Test (SAAT) was given to children diagnosed as having Attention-Deficit Hyperactive Disorder (ADHD) twice: after the administration of methylphenidate, and after the administration of a placebo. Children in the control group were tested twice, but without drugs or placebos. Results revealed no simple drug effect, but a strong order effect. The implications of using the SAAT as a predictor of auditory attention deficits and concerns regarding its test-retest reliability are discussed.

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Pollard, A., A. Hauson, N. Stelmach, et al. "A-25 Paced Auditory Serial Addition Test in Individuals with Cocaine Versus Methamphetamine Dependence." Archives of Clinical Neuropsychology 34, no. 6 (2019): 884. http://dx.doi.org/10.1093/arclin/acz034.25.

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Abstract Objective Research suggests that cocaine and methamphetamine differ in their impact on executive functions (EF). The Paced Auditory Serial Addition Test (PASAT) is used to assess working memory; a component of EF. The purpose of this meta-analysis was to examine the difference between the effect of these two drugs on PASAT scores. Data Selection Three researchers independently searched nine databases (e.g., PsycINFO, Pubmed, ProceedingsFirst), extracted required data, and calculated effect sizes. Inclusion criteria identified studies that had (a) compared cocaine or methamphetamine de

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Nenna, Antonio, Francesco Nappi, Mario Lusini, et al. "Effect of Statins on Platelet Activation and Function: From Molecular Pathways to Clinical Effects." BioMed Research International 2021 (January 23, 2021): 1–10. http://dx.doi.org/10.1155/2021/6661847.

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Purpose. Statins are a class of drugs widely used in clinical practice for their lipid-lowering and pleiotropic effects. In recent years, a correlation between statins and platelet function has been unveiled in the literature that might introduce new therapeutic indications for this class of drugs. This review is aimed at summarizing the mechanisms underlying statin-platelet interaction in the cardiologic scenario and building the basis for future in-depth studies. Methods. We conducted a literature search through PubMed, Embase, EBSCO, Cochrane Database of Systematic Reviews, and Web of Scien

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Raha, Sandeep, Valerie H. Taylor, and Alison C. Holloway. "Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved?" Journal of Pregnancy 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/315203.

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There is currently considerable uncertainty regarding prescribing practices for pregnant women with severe and persistent psychiatric disorders. The physician and the mother have to balance the risks of untreated psychiatric illness against the potential fetal toxicity associated with pharmacological exposure. This is especially true for women taking atypical antipsychotics. Although these drugs have limited evidence for teratological risk, there are reports of altered fetal growth, both increased and decreased, with maternal atypical antipsychotic use. These effects may be mediated through ch

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Easterday, Mary, Patrick N. Plyler, James D. Lewis, and Steven M. Doettl. "Effect of Intensity Level and Speech Stimulus Type on the Vestibulo-Ocular Reflex." Journal of the American Academy of Audiology 30, no. 09 (2019): 792–801. http://dx.doi.org/10.3766/jaaa.18016.

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AbstractAccurate vestibulo-ocular reflex (VOR) measurement requires control of extravestibular suppressive factors such as visual fixation. Although visual fixation is the dominant suppressor and has been extensively studied, the mechanisms underlying suppression from nonvisual factors of attention and auditory stimulation are less clear. It has been postulated that the nonvisual suppression of the VOR is the result of one of two mechanisms: (1) activation of auditory reception areas excites efferent pathways to the vestibular nuclei, thus inhibiting the VOR or (2) cortical modulation of the V

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Gastaldelli, Amalia, Norbert Stefan, and Hans-Ulrich Häring. "Liver-targeting drugs and their effect on blood glucose and hepatic lipids." Diabetologia 64, no. 7 (2021): 1461–79. http://dx.doi.org/10.1007/s00125-021-05442-2.

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AbstractThe global epidemic of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) and the high prevalence among individuals with type 2 diabetes has attracted the attention of clinicians specialising in liver disorders. Many drugs are in the pipeline for the treatment of NAFLD/NASH, and several glucose-lowering drugs are now being tested specifically for the treatment of liver disease. Among these are nuclear hormone receptor agonists (e.g. peroxisome proliferator-activated receptor agonists, farnesoid X receptor agonists and liver X receptor agonists), fibroblast growth fact

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Korostenskaja, M., K. Dapsys, A. Siurkute, et al. "the Effect of Quetiapine on Auditory p300 Response in Patients with Schizoaffective Disorder: Preliminary Study." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)71364-1.

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Abnormalities in attention, memory and information processing are considered to be the primary deficits in schizophrenia. Event-related potential (ERP) P300 could reflect deficits in auditory information processing related to active attention in schizophrenia patients. Atypical antipsychotics tend to ameliorate cognitive deficits, however their effects on neural aspects of cognitive dysfunction have not been consistent.Aim:To investigate the effects of quetiapine on auditory information processing by using auditory P300.Methods:We examined 7 patients with schizoaffective disorder, depressive t

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Kanherkar, Riya R., Bruk Getachew, Joseph Ben-Sheetrit, et al. "The Effect of Citalopram on Genome-Wide DNA Methylation of Human Cells." International Journal of Genomics 2018 (July 25, 2018): 1–12. http://dx.doi.org/10.1155/2018/8929057.

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Commonly used pharmaceutical drugs might alter the epigenetic state of cells, leading to varying degrees of long-term repercussions to human health. To test this hypothesis, we cultured HEK-293 cells in the presence of 50 μM citalopram, a common antidepressant, for 30 days and performed whole-genome DNA methylation analysis using the NimbleGen Human DNA Methylation 3x720K Promoter Plus CpG Island Array. A total of 626 gene promoters, out of a total of 25,437 queried genes on the array (2.46%), showed significant differential methylation (p<0.01); among these, 272 were hypomethylated and 354

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Stein, Barry E., Nancy London, Lee K. Wilkinson, and Donald D. Price. "Enhancement of Perceived Visual Intensity by Auditory Stimuli: A Psychophysical Analysis." Journal of Cognitive Neuroscience 8, no. 6 (1996): 497–506. http://dx.doi.org/10.1162/jocn.1996.8.6.497.

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Judgments of the intensity of a stimulus are dependent on the level of central nervous system activity it generates. Generally, it is assumed that such judgments are based on activity along modality-specific pathways. Thus, visual intensity judgments would be based on unimodal visual activity. However, many neurons do not fit neatly within modality-specific categories, but can be influenced by more than one sensory modality. Often the “multisensory” effect is quite pronounced. If these multisensory neurons participate in such fundamental functions as perceived intensity, the presence of a nonv

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Fong, Robert, Suhail Khokhar, Atif N. Chowdhury, et al. "Caffeine accelerates recovery from general anesthesia via multiple pathways." Journal of Neurophysiology 118, no. 3 (2017): 1591–97. http://dx.doi.org/10.1152/jn.00393.2017.

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Various studies have explored different ways to speed emergence from anesthesia. Previously, we have shown that three drugs that elevate intracellular cAMP (forskolin, theophylline, and caffeine) accelerate emergence from anesthesia in rats. However, our earlier studies left two main questions unanswered. First, were cAMP-elevating drugs effective at all anesthetic concentrations? Second, given that caffeine was the most effective of the drugs tested, why was caffeine more effective than forskolin since both drugs elevate cAMP? In our current study, emergence time from anesthesia was measured

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Ide, Hideto, and Masafumi Uchida. "Frequency Analysis System for Auditory Nerves with Auditory Brainstem Response (ABR) by Harmonious Tone." Journal of Robotics and Mechatronics 8, no. 2 (1996): 163–66. http://dx.doi.org/10.20965/jrm.1996.p0163.

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Generally, sounds are composed of three parts, i.e., loudness, pitch, and tone color. The auditory system completes the frequency analysis of these components between peripheral nerve and medial geniculate body. Cerebrum cortex unite the result of analysis and past memories, and perform high level perceptional prudence. The system of frequency analysis has many unknown parts. If these parts are analyzed and explained, the comfort or discomfort to sounds and the human music sense can be clarified. In addition, it can be applied to medial and human engineering etc. As the new method of the syste

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Ota, Y., D. L. Oliver, and D. F. Dolan. "Frequency-Specific Effects on Cochlear Responses During Activation of the Inferior Colliculus in the Guinea Pig." Journal of Neurophysiology 91, no. 5 (2004): 2185–93. http://dx.doi.org/10.1152/jn.01155.2003.

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The inferior colliculus (IC) is a major processing center in the ascending auditory pathway. The role of the IC in the descending efferent auditory system is less clear. Although the IC central nucleus (ICC) is the major relay station for the ascending auditory pathways, the IC's cortex receives its main input from the neocortex and nonauditory sources. The goal of this study was to determine if the IC subdivisions had different functions in the descending efferent auditory system. IC subdivisions were identified by their tuning curves evoked by tone stimulation, and the effects of localized e

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Wang, Shifei, Cheng Rao, Xingyu Huang, Tianhong Xie, Linling Su, and Huan Li. "Regulating Age-Related Hearing Loss with Bisphenol A via the Long Non-Coding RNA X Inactive Specific Transcript and MicroRNA-34a-5p Pathways." Nanoscience and Nanotechnology Letters 12, no. 8 (2020): 987–95. http://dx.doi.org/10.1166/nnl.2020.3200.

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Age-related hearing loss (AHL) is a common, high-incidence, perceptual disease in the elderly population worldwide. Since bisphenol A (BPA) has been reported to associate with cell apoptosis, we hypothesize that BPA can inhibit the neuronal apoptosis in AHL. Forty Wistar rats were recruited to model AHL; they were then treated with different doses of BPA. We used auditory brainstem response testing to measure the BPA-induced improvement in the rats’ hearing. We examined the proliferation and apoptosis of the auditory cortical neurons in the rats with MTT assay and flow cytometry. Also, to deli

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Gruters, Kurtis G., David L. K. Murphy, Cole D. Jenson, David W. Smith, Christopher A. Shera, and Jennifer M. Groh. "The eardrums move when the eyes move: A multisensory effect on the mechanics of hearing." Proceedings of the National Academy of Sciences 115, no. 6 (2018): E1309—E1318. http://dx.doi.org/10.1073/pnas.1717948115.

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Interactions between sensory pathways such as the visual and auditory systems are known to occur in the brain, but where they first occur is uncertain. Here, we show a multimodal interaction evident at the eardrum. Ear canal microphone measurements in humans (n = 19 ears in 16 subjects) and monkeys (n = 5 ears in three subjects) performing a saccadic eye movement task to visual targets indicated that the eardrum moves in conjunction with the eye movement. The eardrum motion was oscillatory and began as early as 10 ms before saccade onset in humans or with saccade onset in monkeys. These eardru

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Takeuchi, Makoto, Michihiro Tanikawa, Kazunori Nagasaka, et al. "Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells." Cancers 11, no. 12 (2019): 1913. http://dx.doi.org/10.3390/cancers11121913.

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While the incidence of endometrial cancer continues to rise, the therapeutic options remain limited for advanced or recurrent cases, and most cases are resistant to therapy. The anti-tumor effect of many chemotherapeutic drugs and radiotherapy depends on the induction of DNA damage in cancer cells; thus, activation of DNA damage response (DDR) pathways is considered an important factor affecting resistance to therapy. When some DDR pathways are inactivated, inhibition of other DDR pathways can induce cancer-specific synthetic lethality. Therefore, DDR pathways are considered as promising candi

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Claes, Laura, Hannah Stamberger, Paul Van de Heyning, Dirk De Ridder, and Sven Vanneste. "Auditory Cortex tACS and tRNS for Tinnitus: Single versus Multiple Sessions." Neural Plasticity 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/436713.

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Tinnitus is the perception of a sound in the absence of an external acoustic source, which often exerts a significant impact on the quality of life. Currently there is evidence that neuroplastic changes in both neural pathways are involved in the generation and maintaining of tinnitus. Neuromodulation has been suggested to interfere with these neuroplastic alterations. In this study we aimed to compare the effect of two upcoming forms of transcranial electrical neuromodulation: alternating current stimulation (tACS) and random noise stimulation (tRNS), both applied on the auditory cortex. A da

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Dammann, Kyle, Vineeta Khare, Clyde Coleman, Henrik Berdel, and Christoph Gasche. "p-21 Activated Kinase as a Molecular Target for Chemoprevention in Diabetes." Geriatrics 3, no. 4 (2018): 73. http://dx.doi.org/10.3390/geriatrics3040073.

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Hypothesis: Anti-diabetic drugs modulate p-21 activated kinase (PAK) signaling. Introduction: Type 2 diabetes mellitus (T2DM) is a chronic inflammatory disease associated with increased cancer risk. PAK signaling is implicated in cellular homeostasis when regulated, and cancer when unrestrained. Recent reports provided a role for PAK signaling in glucose homeostasis, but the role of PAKs in the pathogenesis of T2DM is unknown. Here, we performed a mini-meta-analysis to explore if anti-diabetic drugs modify PAK signaling pathways, and provide insight regarding modulation of these pathways, to p

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de Anda-Jáuregui, Guillermo, Kai Guo, and Junguk Hur. "Network-Based Assessment of Adverse Drug Reaction Risk in Polypharmacy Using High-Throughput Screening Data." International Journal of Molecular Sciences 20, no. 2 (2019): 386. http://dx.doi.org/10.3390/ijms20020386.

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The risk of adverse drug reactions increases in a polypharmacology setting. High-throughput drug screening with transcriptomics applied to human cells has shown that drugs have effects on several molecular pathways, and these affected pathways may be predictive proxy for adverse drug reactions. Depending on the way that different drugs may contribute to adverse drug reactions, different options may exist in the clinical setting. Here, we formulate a network framework to integrate the relationships between drugs, biological functions, and adverse drug reactions based on the high-throughput drug

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Avan, Paul, Fabrice Giraudet, and Béla Büki. "Importance of Binaural Hearing." Audiology and Neurotology 20, Suppl. 1 (2015): 3–6. http://dx.doi.org/10.1159/000380741.

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An essential task for the central auditory pathways is to parse the auditory messages sent by the two cochleae into auditory objects, the segregation and localisation of which constitute an important means of separating target signals from noise and competing sources. When hearing losses are too asymmetric, the patients face a situation in which the monaural exploitation of sound messages significantly lessens their performance compared to what it should be in a binaural situation. Rehabilitation procedures must aim at restoring as many binaural advantages as possible. These advantages encompa

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Mao, Yu-Ting, Tian-Miao Hua, and Sarah L. Pallas. "Competition and convergence between auditory and cross-modal visual inputs to primary auditory cortical areas." Journal of Neurophysiology 105, no. 4 (2011): 1558–73. http://dx.doi.org/10.1152/jn.00407.2010.

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Sensory neocortex is capable of considerable plasticity after sensory deprivation or damage to input pathways, especially early in development. Although plasticity can often be restorative, sometimes novel, ectopic inputs invade the affected cortical area. Invading inputs from other sensory modalities may compromise the original function or even take over, imposing a new function and preventing recovery. Using ferrets whose retinal axons were rerouted into auditory thalamus at birth, we were able to examine the effect of varying the degree of ectopic, cross-modal input on reorganization of dev

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Ding, Yanting, Yilian Li, Qin Chen, and Bing Niu. "Advances in Antidiabetic Drugs Targeting Insulin Secretion." Current Pharmaceutical Design 24, no. 34 (2019): 3990–97. http://dx.doi.org/10.2174/1381612824666181112113756.

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Background: Diabetes mellitus (DM) is a disease of systemic metabolic disorders caused by the decrease of secretion or sensitivity of insulin. In recent years, the study of insulin-related drug targets and the development of new drugs have become the popular topic of current medical research, and studies have shown that multiple signaling pathways are associated with diabetes treatment. At present, some new drugs based on the new target design have been listed on the market and have achieved good hypoglycemic effect. However, most of the drugs are still in the clinical or pre-clinical stage. T

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Schipper, R. G., L. P. van den Heuvel, A. A. J. Verhofstad, and R. A. De Abreu. "Polyamines and DNA methylation in childhood leukaemia." Biochemical Society Transactions 35, no. 2 (2007): 331–35. http://dx.doi.org/10.1042/bst0350331.

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Both polyamine metabolism and DNA methylation play an important role in normal and malignant growth. Specific enzyme inhibitors or drugs that interfere with these metabolic pathways have proven to be potential anticancer agents. Since DNA methylation and polyamine metabolism depend on a common substrate, i.e. S-adenosylmethionine, interaction between both pathways can be expected. Little is known about the relationship between these pathways but studies are available indicating that polyamines and DNA methylation are directly or indirectly interconnected, metabolically as well as physiological

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Topdag, M., M. Iseri, E. Gelenli, et al. "Effect of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity." Journal of Laryngology & Otology 126, no. 11 (2012): 1091–96. http://dx.doi.org/10.1017/s0022215112001855.

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AbstractObjective:This study aimed to contribute to the literature on the prevention and treatment of ototoxicity due to various drugs and chemicals.Material and methods:This study compared the histological effects of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity, in 36 rats.Results:Dexamethasone and memantine had significant effects on the stria vascularis, organ of Corti and spiral ganglion (p < 0.05). Although piracetam decreased the apoptosis rate, this effect was not statistically significant (p > 0.05).Conclusion:Dexamethaso

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Pham, Thu Nguyen Minh, Seo Yeon Jeong, Do Hoon Kim, et al. "Protective Mechanisms of Avocado Oil Extract Against Ototoxicity." Nutrients 12, no. 4 (2020): 947. http://dx.doi.org/10.3390/nu12040947.

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Despite the excellent antimicrobial activity of aminoglycoside antibiotics, permanent inner ear damage associated with the use of these drugs has resulted in the need to develop strategies to address the ototoxic risk given their widespread use. In a previous study, we showed that avocado oil protects ear hair cells from damage caused by neomycin. However, the detailed mechanism by which this protection occurs is still unclear. Here, we investigated the auditory cell-protective mechanism of enhanced functional avocado oil extract (DKB122). RNA sequencing followed by pathway analysis revealed t

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Cervantes, Blanca, Lide Arana, Silvia Murillo-Cuesta, Marina Bruno, Itziar Alkorta, and Isabel Varela-Nieto. "Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity." Journal of Clinical Medicine 8, no. 9 (2019): 1464. http://dx.doi.org/10.3390/jcm8091464.

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Cisplatin is a chemotherapeutic agent that causes the irreversible death of auditory sensory cells, leading to hearing loss. Local administration of cytoprotective drugs is a potentially better option co-therapy for cisplatin, but there are strong limitations due to the difficulty of accessing the inner ear. The use of nanocarriers for the efficient delivery of drugs to auditory cells is a novel approach for this problem. Solid lipid nanoparticles (SLNs) are biodegradable and biocompatible nanocarriers with low solubility in aqueous media. We show here that stearic acid-based SLNs have the ade

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Athira, A. P., C. S. Abhinand, K. Saja, A. Helen, P. Reddanna та P. R. Sudhakaran. "Anti-angiogenic effect of chebulagic acid involves inhibition of the VEGFR2- and GSK-3β-dependent signaling pathways". Biochemistry and Cell Biology 95, № 5 (2017): 563–70. http://dx.doi.org/10.1139/bcb-2016-0132.

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Inhibition of angiogenesis is a useful strategy to prevent cancer growth by targeting new vessels that grow to nourish actively proliferating tumor cells. Endothelial cells can use a number of different pathways to cause angiogenesis, and each step in these pathways can be targeted. The use of multi-targeted drugs is gaining much importance in this scenario. Our previous results have shown that chebulagic acid (a benzopyran tannin present in the fruits of Terminalia chebula) has anti-angiogenic properties. Thus, this study was designed to examine the molecular mechanism for the anti-angiogenic

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Stephan, Denise Nadine, Iring Koch, Jessica Hendler, and Lynn Huestegge. "Task Switching, Modality Compatibility, and the Supra-Modal Function of Eye Movements." Experimental Psychology 60, no. 2 (2013): 90–99. http://dx.doi.org/10.1027/1618-3169/a000175.

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Previous research suggested that specific pairings of stimulus and response modalities (visual-manual and auditory-vocal tasks) lead to better dual-task performance than other pairings (visual-vocal and auditory-manual tasks). In the present task-switching study, we further examined this modality compatibility effect and investigated the role of response modality by additionally studying oculomotor responses as an alternative to manual responses. Interestingly, the switch cost pattern revealed a much stronger modality compatibility effect for groups in which vocal and manual responses were com

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Chikara, Rupesh Kumar, and Li-Wei Ko. "Modulation of the Visual to Auditory Human Inhibitory Brain Network: An EEG Dipole Source Localization Study." Brain Sciences 9, no. 9 (2019): 216. http://dx.doi.org/10.3390/brainsci9090216.

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Auditory alarms are used to direct people’s attention to critical events in complicated environments. The capacity for identifying the auditory alarms in order to take the right action in our daily life is critical. In this work, we investigate how auditory alarms affect the neural networks of human inhibition. We used a famous stop-signal or go/no-go task to measure the effect of visual stimuli and auditory alarms on the human brain. In this experiment, go-trials used visual stimulation, via a square or circle symbol, and stop trials used auditory stimulation, via an auditory alarm. Electroen

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Li, Dong, Aixin Li, Hairui Zhou, et al. "Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches." International Journal of Genomics 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/9264034.

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Drug-induced myopathy (DIM) is a rare side effect; however, the consequence could be fatal. There are few reports to systematically assess the underlying mechanism of DIM. In this study, we curated the comprehensive DIM drug list based on structured labeling products (SPLs) and carried out the analysis based on chemical structure space, drug protein interaction, side effect space, and transcriptomic profiling space. Some key features are enriched from each of analysis. Specifically, the similarity of DIM drugs is more significant than random chance, which shows that the chemical structure coul

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