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Articles de revues sur le sujet « Autoimmune oral lesion »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

L., Vijayalakshmi, Bharathi S., and Manipriya S. "A Clinico Epidemiological Study of Oral Manifestations in Auto Immune Skin Diseases." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 1396–400. https://doi.org/10.5281/zenodo.11202636.

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<strong>Introduction:</strong>  Autoimmune diseases are characterized by presence of auto antibodies that are directed against structures of the self-resulting in tissue damage and degeneration. Auto immune disorder often involves oral mucosa. Oral involvement is the first and most important or often it may be the only sign of such disease process. Oral mucosal lesions are erythema, erosions, ulcers rarely vesicle which are clinically similar and often non-specific. Timely recognition and therapy of oral lesion is critical as it may prevent skin involvement in pemphigus vulgaris. Based on

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Tarakji, Bassel. "Pemphigus Vulgaris in Old Patient." Case Reports in Dentistry 2021 (August 23, 2021): 1–3. http://dx.doi.org/10.1155/2021/3946161.

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Pemphigus vulgaris (PV) is a chronic, autoimmune, intraepidermal blistering disease of the skin and mucous membranes. The first clinical manifestation is often the development of intraoral lesions, and later, the lesions involve the other mucous membranes and skin. The etiological factors of this disease still remain unknown, although the presence of autoantibodies is consistent with an autoimmune disease. A 73-year-old man had bullous lesions on gingiva, oral mucosa first, then scalp, trunk, and face. An oral medicine specialist suspects the lesion in differential diagnosis in the first prese

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Pinheiro, Juliana Barchelli, Camila Tirapelli, Claudia Helena Lovato da Silva, et al. "Oral Nodular Lesions in Patients with Sjögren’s Syndrome: Unusual Oral Implications of a Systemic Disorder." Brazilian Dental Journal 28, no. 3 (2017): 405–12. http://dx.doi.org/10.1590/0103-6440201601013.

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Abstract Sjögren’s syndrome (SS) is a systemic chronic autoimmune disorder affecting the lacrimal and salivary glands. SS may manifest as primary SS (pSS) or secondary SS (sSS), the latter occurring in the context of another autoimmune disorder. In both cases, the dry eyes and mouth affect the patient’s quality of life. Late complications may include blindness, dental tissue destruction, oral candidiasis and lymphoma. This paper reports two cases of SS, each of them presenting unusual oral nodular lesion diagnosed as relapsed MALT lymphoma and mucocele. The importance of the diagnosis, treatme

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Anitua, Eduardo, Mohammad H. Alkhraisat, Asier Eguia, and Laura Piñas. "Oral Pemphigoid Recalcitrant Lesion Treated with PRGF Infiltration. Case Report." Dentistry Journal 9, no. 11 (2021): 137. http://dx.doi.org/10.3390/dj9110137.

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Mucous membrane pemphigoid (MMP) is a heterogeneous group of chronic autoimmune subepithelial blistering diseases. Oral involvement is present in almost all patients, may represent the onset of the disease, and causes different degrees of pain, dysphagia, soreness, and bleeding. Treatment is based on systemic and/or oral corticoids, or other immunosuppressants. Occasionally, oral lesions can show a poor response to standard treatments. We present the case of a 61-year-old female patient with a painful extensive MMP oral ulcerative lesion recalcitrant to previous systemic azathioprine and local

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Bhateja, Sumit, Aksilat Saciideva, Geetika Arora, Vaibhav Malhotra, and Taniya Malhotra. "Ocular manifestations of oral mucosal lesions." Indian Journal of Clinical and Experimental Ophthalmology 10, no. 4 (2024): 627–33. https://doi.org/10.18231/j.ijceo.2024.110.

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Autoimmune blistering diseases refer to a diverse group of conditions that primarily target the skin and mucosa. However, in some cases, other organ systems can be involved, depending on the specific pathophysiology of the disease. Owing to the increased possibility of blindness associated with delayed diagnosis and treatment, it is essential to be aware of and detect ocular manifestations of these diseases at an early stage. The present article discusses the various oral mucosal lesions encountered in daily practice with emphasis on the ocular manifestations of each lesion.

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Kitakawa, Dárcio, Gabriela Máximo, Maria Clara Ferreira Coelho, Felipe da Silva Peralta, Dárcio Kitakawa, and Luis Felipe das Chagas e Silva de Carvalh. "Erythema multiforme: A case report with oral manifestations." International Journal of Case Reports and Images 13, no. 2 (2023): 61–65. http://dx.doi.org/10.5348/101328z01gm2022cr.

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Introduction: Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disease, which may be related to herpes simplex virus, use of certain medications, autoimmune disease, radiation, immunization, pregnancy, period, and food additives or chemicals. It is a condition that occurs predominantly in young adults, with a slight female preponderance and no predilection. Clinically, EM presents erosive and erythematous plaques, affecting mainly the lips and oral mucosa, called target lesions, which may progress to vesiculobullous lesions. The aim of this study is to report a case shown as

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Cai, Q., and T. Yoo. "Oral Administration Decreases Autoimmune Hearing Loss Lesion in the Mice." Journal of Allergy and Clinical Immunology 117, no. 2 (2006): S18. http://dx.doi.org/10.1016/j.jaci.2005.12.073.

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Serpico, R., G. Pannone, A. Santoro, et al. "Report of a Case of Discoid Lupus Erythematosus Localised to the Oral Cavity: Immunofluorescence Findings." International Journal of Immunopathology and Pharmacology 20, no. 3 (2007): 651–53. http://dx.doi.org/10.1177/039463200702000325.

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Discoid Lupus Erythematosus (DLE) is a chronic disease with a typical cutaneous involvement. This pathology rarely involves mucosa: oral cavity is interested in 20% of DLE patients. We describe a case of oral DLE in a 50-year-old woman with an anamnesis for autoimmune disorders. This study shows the helpful role of immunofluorescence in the diagnosis of autoimmune diseases. The first diagnostic step was the clinical observation of the oral mucosa: the lesion area was erythematous, athrophic and hyperkeratotic. The patient then underwent laboratory examination. We utilized human epithelial cell

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Ohki, Masafumi, and Shigeru Kikuchi. "Nasal, Oral, and Pharyngolaryngeal Manifestations of Pemphigus Vulgaris: Endoscopic Ororhinolaryngologic Examination." Ear, Nose & Throat Journal 96, no. 3 (2017): 120–27. http://dx.doi.org/10.1177/014556131709600311.

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Pemphigus vulgaris is an autoimmune blistering disorder that involves the skin and mucous membranes. Few reports have described nasal and oropharyngolaryngeal lesions in pemphigus vulgaris using an endoscopic ororhinolaryngologic examination. We retrospectively reviewed the clinical records of 11 patients with pemphigus vulgaris between 2001 and 2013 with respect to their symptoms, lesion sites, lesion features, and treatments received. All patients had undergone an endoscopic ororhinolaryngologic examination. Their mucosa-related symptoms were sore throat, oral pain, odynophagia, gingival ble

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Sadat, SM Anwar, and Akhter Imam. "Pemphigus Vulgaris as Oral Mucosal Ulcer Progressive to Skin Lesion:." Update Dental College Journal 3, no. 2 (2014): 43–47. http://dx.doi.org/10.3329/updcj.v3i2.17999.

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Among all the life threatening diseases, autoimmune diseases are among most notorious and complicated diseases. As these diseases have no specific cause or responsible organism, it is therefore very difficult to distinguish and diagnose and thus stands as a major threat for public health. It is assumed that the reason for these diseases may be from genetic to environmental factors, from stress to idiopathic origin. Pemphigus Vulgaris(PV) is such an autoimmune blistering disease that frequently affects the mucous membrane and skin. Very often it starts from oral cavity and Dentists therefore th

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Jimenez, Antonio, Paige Hoyer, and Michael Wilkerson. "An Atypical Presentation of Pemphigus Vegetans in the Umbilicus." SKIN The Journal of Cutaneous Medicine 4, no. 5 (2020): 452–55. http://dx.doi.org/10.25251/skin.4.5.12.

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Pemphigus is a chronic, autoimmune bullous disease that affects the skin and mucous membranes. Pemphigus vegetans is a rare variant of pemphigus and presents as oral ulcerations with associated verrucous lesions in intertriginous or flexural areas. A 38-year-old African American woman presented to the clinic with a chief complaint of oral ulcers. She carried a diagnosis of Behcet’s disease and was referred by rheumatology for evaluation of treatment-resistant mucosal ulcerations. At the time of her dermatology visit, she also reported an enlarging umbilical mass that had been present for sever

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Raffaele, Regina Maria, Mario Eduardo Baldo, Pamela Ferreira de Sá Queiroz, Ricardo Yudi Tateno, Luiz Felipe Palma, and Luana Campos. "Phototherapies in the management of an ulcerative lip lesion in a patient taking multiple medications for rheumatoid arthritis." Research, Society and Development 10, no. 8 (2021): e50210817538. http://dx.doi.org/10.33448/rsd-v10i8.17538.

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The treatment of rheumatoid arthritis (RA), an inflammatory autoimmune disease of chronic nature, consists of medications, exercises, patient education on the disease, and rest. Unfortunately, many drugs used for RA have been recently recognized to induce oral manifestations due to either immunosuppression or antiproliferative effects. Thus, the present study reports a case of a patient who was receiving multiple medications (methotrexate, leflunomide, and sodium risedronate) for RA and developed an extensive lip ulcerative lesion not responsive to previous treatments. The lesion management wa

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Arbune, Manuela, Monica-Daniela Padurariu-Covit, Elena Niculet, Iulia Chiscop, Anca-Adriana Arbune, and Alin-Laurențiu Tatu. "Ulceration and a White Lesion of the Tongue in a Male HIV Positive Patient: A Journey on the Avenue of Differential Diagnoses in Search of a Solution." Life 13, no. 4 (2023): 901. http://dx.doi.org/10.3390/life13040901.

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Oral lesions are early indicator of immunosuppression, leading to HIV new diagnoses. The type of oral lesions can reveal opportunistic diseases that are correlated with the severity of immune depletion. Highly active antiretroviral therapy decreases the incidence of opportunistic oral infections, whereas a large variety of lesions are frequently experienced in people with HIV. Overlapping pathogenic mechanisms and multiple contributing etiologies are related to unusual, atypical oral lesions that are challenging in the clinical practice. We present a rare case of eosinophilic granuloma of the

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Leone, Corolina, Norberto Sugaya, and Dante Migliari. "An Intriguing Case of Ectopic Benign Migratory Glossitis Resembling Secondary Syphilis: A Case Report." Case Reports in Dermatology 12, no. 3 (2020): 262–65. http://dx.doi.org/10.1159/000510776.

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Oral mucosal lesions presenting as erythematous patches usually pose difficulties for a clinical diagnosis. They elicit an array of differential diagnosis that mainly includes oral candidosis, contact mucosal reaction, oral lichenoid lesion, oral psoriasiform, autoimmune disease, and, not to forget, secondary syphilis. In this present case, all those above-mentioned possibilities were ruled out, while secondary syphilis stood as the main diagnosis. As this was also later excluded by a negative serological treponemal test, the final diagnosis rested on an ectopic manifestation of benign migrato

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Olisova, Olga Yu, and Natalia P. Teplyuk. "Photogallery of diseases of the oral mucosa. Part II." Russian Journal of Skin and Venereal Diseases 25, no. 6 (2023): 83–86. http://dx.doi.org/10.17816/dv113013.

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Nowadays there are more than 300 types of diseases of the oral mucosa and the red fringe of the lips. The etiology of these lesions is extremely diverse and includes primary and secondary infectious diseases of bacterial, fungal and viral origin, autoimmune diseases, etc. In addition, there are a number of features associated with the age of manifestation of a particular lesion. For example, in childhood, primary rashes with herpes simplex often appear precisely on the oral mucosa. In adults, along with widespread rashes on the skin, it is possible to damage the oral mucosa in Kaposi's sarcoma

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Gurumoorthi, Ragesh, Saranya Ramasamy, and Sindhiya Kulandaisamy. "A Case of Bullous Pemphigoid - Potentially Fatal Condition." International Journal of Health Sciences and Research 12, no. 10 (2022): 150–53. http://dx.doi.org/10.52403/ijhsr.20221019.

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Bullous pemphigoid is a rare autoimmune skin disorder characterized by enormous, fluid – filled blisters that appear on skin lower belly, upper thighs and armpits. It occurs when the body’s immune system targets the tissue layer beneath the top layer of skin. The cause of this attack is not known. A 48 years old male patient received in the ward with the complaints of fluid filled lesions all over the body including oral cavity, history of rupture of lesions spontaneously to form raw areas, itching before the onset of lesions since 3 days. The incisional biopsy was done and the lesion was clin

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Wahyuni, Indah Suasani, Tenny Setiana Dewi, Erna Herawati, and Dewi Zakiawati. "Profil lesi oral pada penderita penyakit autoimun." Majalah Kedokteran Gigi Indonesia 2, no. 3 (2016): 147. http://dx.doi.org/10.22146/majkedgiind.11311.

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Oral lesion’s profi le in autoimmune disease. Oral lesions are commonly found in patients with autoimmune diseases as manifestations of the disease or a side effect of the treatment. Oral lesions must be handled properly to prevent secondary infection, relieve pain and improve the patient’s quality of life. The aim of this study is to describe oral lesions profile in patients with autoimmune diseases, including clinical characteristics and location of oral lesions as well as the distribution of age and sex of the patient. The methods were retrospective observation by describing the secondary d

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Setiadhi, Riani, and Kosterman Usri. "Oral Lesion Caused by Improper Removable Partial Denture." Jurnal Material Kedokteran Gigi 7, no. 1 (2018): 12. http://dx.doi.org/10.32793/jmkg.v7i1.275.

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Oral lesions are relatively common findings in clinical practice, can occur due to various factors such as trauma, systemic diseases, autoimmune disorders, malignancies. Local trauma as one of the cause of oral lesions majority due to poor dentures, fractured restorations and sharp edges of teeth. The lesions are commonly found on the mucosa that is subjected to the source of trauma such as buccal mucosa, lateral border of the tongue or lips. Removable partial denture is a denture that can be removed and reinserted without professional help. Poor removable denture which is an ill-fitting dentu

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Sugerman, P. B., N. W. Savage, L. J. Walsh, et al. "The Pathogenesis of Oral Lichen Planus." Critical Reviews in Oral Biology & Medicine 13, no. 4 (2002): 350–65. http://dx.doi.org/10.1177/154411130201300405.

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Both antigen-specific and non-specific mechanisms may be involved in the pathogenesis of oral lichen planus (OLP). Antigen-specific mechanisms in OLP include antigen presentation by basal keratinocytes and antigen-specific keratinocyte killing by CD8+ cytotoxic T-cells. Non-specific mechanisms include mast cell degranulation and matrix metalloproteinase (MMP) activation in OLP lesions. These mechanisms may combine to cause T-cell accumulation in the superficial lamina propria, basement membrane disruption, intra-epithelial T-cell migration, and keratinocyte apoptosis in OLP. OLP chronicity may

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Baral, Radha, Bidhata Ojha, and Dipshikha Bajracharya. "ORAL PEMPHIGUS VULGARIS: A CASE REPORT." Journal of Chitwan Medical College 10, no. 1 (2020): 91–93. http://dx.doi.org/10.54530/jcmc.137.

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Pemphigus vulgaris is an autoimmune blistering disease clinically presenting as vesicles, bullae and erosion on the skin and mucous membrane. Histopathologically, it is characterized by acantholysis and supra basilar split. The underlying mechanism causing intra epithelial split in pemphigus vulgaris is binding of IgG autoantibodies to desmoglin 3 which belongs to a transmembrane glycoprotein adhesion molecule. Here we present a case of 27 years old male patient suffering from pemphigus vulgaris. This Case report highlights the importance of detailed case history, thorough clinical examinati

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Baral, Radha, Bidhata Ojha, and Dipshikha Bajracharya. "Oral Pemphigus Vulgaris: A case report." Journal of Chitwan Medical College 10, no. 1 (2020): 91–93. http://dx.doi.org/10.3126/jcmc.v10i1.28082.

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Pemphigus vulgaris is an autoimmune blistering disease clinically presenting as vesicles, bullae and erosion on the skin and mucous membrane. Histopathologically, it is characterized by acantholysis and supra basilar split. The underlying mechanism causing intra epithelial split in pemphigus vulgaris is binding of IgG autoantibodies to desmoglin 3 which belongs to a transmembrane glycoprotein adhesion molecule. Here we present a case of 27 years old male patient suffering from pemphigus vulgaris. This Case report highlights the importance of detailed case history, thorough clinical examinati

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Naritasari, Fimma, Ayu Fresno Argadianti, and Nida Arum Fadilah. "Management of erosive oral lichen planus." MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM 10, no. 2 (2024): 61. https://doi.org/10.22146/mkgk.101017.

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Oral lichen planus (OLP) is an autoimmune disease that commonly affects the mucocutaneous area. The etiology of OLP remains unclear, but several factors are considered risk factors, such as chronic liver disease (hepatitis C infection), stress, genetics, hypertension, diabetes, smoking, and tobacco chewing. OLP often causes pain, especially during exacerbation periods. OLP management aims to reduce symptoms, improve clinical conditions, reduce the riskof oral cancer, and maintain oral health. This case report presents a case of OLP in a 54-year-old Javanese female patient with complaints of pa

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Čēma, Ingrīda, Jagriti Kakar, Madara Dzudzilo, and Modra Murovska. "Immunological Aspects of EBV and Oral Mucosa Interactions in Oral Lichen Planus." Applied Sciences 13, no. 11 (2023): 6735. http://dx.doi.org/10.3390/app13116735.

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Oral lichen planus (OLP) is considered a T cell-mediated chronic inflammatory process activated by an unknown antigen, making basal keratinocytes vulnerable to a cytotoxic cell mediated immune response. The aim of this review is to summarize information on the role and pathways of Epstein–Barr virus (EBV) and immune cells in inducing OLP as an autoimmune lesion. The pathogenesis of OLP is analyzed from immunological aspects of interactions between EBV and oral mucosa. The results of the available studies allow us to assume that EBV can act both as an exogenous and an endogenous antigen in the

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Nidhi, Ojha, and Prakash Yadav Om. "Benign Mucous Membrane Pemphigoid: A Case Report." International Healthcare Research Journal 4, no. 2 (2020): 34–37. https://doi.org/10.26440/IHRJ/0402.05333.

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Benign Mucous Membrane Pemphigoid (MMP) is a vesiculobullous (VB) lesion that affects oral and nasal mucosa, oropharynx, conjunctiva, and genital mucosa. It is considered an autoimmune disease. Autoantibodies are produced due to several external factors or genetic factors. It creates many complications, such as defects in vision, voice alteration (hoarseness), airway obstruction, and dyspareunia. The subepithelial blisters form due to these antibodies. Treatment modalities differ from topical steroids to systemic steroid therapy based on the nature and severity of clinical symptoms.

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Walid, Ftis. "Evaluation of Clobetasol versus Tacrolimus in Management of Oral Lichen Planus Lesions." Khalij-Libya Journal of Dental and Medical Research 2, no. 2 (2018): 19–28. https://doi.org/10.5281/zenodo.3967786.

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Lichen planus is a muco-cutaneous chronic inflammatory disorder affects, which frequently occurs during the fourth decade of life.  It is a T-cell mediated autoimmune disease in which auto-cytotoxic CD8+ T cells trigger apoptosis of basal cells of oral epithelium.  Corticosteroids are the most commonly used group of drugs for the treatment of OLP. The rationale behind their usage is their ability to modulate inflammation and immune response. The present study compared between the efficacy of clobetazole and Tacrolimus to treat OLP lesions. It has been concluded that Tacrolimus 1% cre

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Nicolatou-Galitis, Ourania, Amanda Psyrri, Nikolaos Tsoukalas, et al. "Oral Toxicities in Cancer Patients, Who Receive Immunotherapy: A Case Series of 24 Patients." Oral 3, no. 1 (2023): 123–33. http://dx.doi.org/10.3390/oral3010011.

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The oral problems of 24 cancer patients on immunotherapy between 2017–2022 and referred by their oncologists, were reported. The age range was 49–80 years, and the median was 64 years. Lung cancer was the most common disease. Three patients a had history of autoimmune disease prior to cancer diagnosis. Patients received immunotherapy for two to 48 months. Prior to immunotherapy, 17 patients received cytotoxic chemotherapy, five angiogenesis inhibitors and one1 radiotherapy to head/neck. During immunotherapy, four patients received chemotherapy, one received bevacizumab, and eight received bone

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Cichońska, Dominika, Dominika Komandera, Magda Mazuś, and Aida Kusiak. "Chronic Ulcerative Stomatitis (CUS) as an Interdisciplinary Diagnostic Challenge: A Literature Review." International Journal of Molecular Sciences 23, no. 22 (2022): 13772. http://dx.doi.org/10.3390/ijms232213772.

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Chronic ulcerative stomatitis (CUS) is a rarely reported disease affecting the oral cavity, most often affecting middle-aged Caucasian females. The aim of the present study is to present the diagnosis, differentiation, and interdisciplinary treatment of this rare disease. CUS is characterized by the presence of an oral erosive or ulcerative lesion. The autoimmune pathogenesis of CUS includes affecting the antigen’s activity by DNA-breaking and protein-hydrolyzing enzymes. The stratified epithelium-specific antinuclear antibodies (SES-ANA) are associated with CUS development. Clinically, the le

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Shenoy, Santhosh, Madhurya N. Kedlaya, Sajna H. R., and Amitha Ramesh. "Oral Mucous Membrane Pemphigoid with Contact Dermatitis - A Rare Clinical Entity." Journal of Health and Allied Sciences NU 08, no. 03 (2018): 041–44. http://dx.doi.org/10.1055/s-0040-1708763.

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AbstractMucous membrane pemphigoid (MMP) is a rare inflammatory, autoimmune, subepithelial vesiculobullous lesion. Oral mucosa is affected in almost 90% of cases. Its development is chronic with a possible involvement of ocular, laryngeal and genital mucosa. Spontaneous remission is rare. Currently, improving oral hygiene, topical corticosteroid treatment is used to control the oral lesions of MMP. In the present case report, a 53 year old female patient with a known history of hypothyroidism reported to the department of Periodontology with a complaint of burning sensation and tenderness in t

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Sarnovská, Tereza, Kateřina Jelínková, Filip Neumann, Dagmar Barnetová, and René Hrdlička. "Autoimmune pancreatitis in childhood." Gastroenterologie a hepatologie 77, no. 2 (2023): 136–39. http://dx.doi.org/10.48095/ccgh2023136.

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Autoimmune pancreatitis is an idiopathic inflammatory disease of the pancreas that is rarely encountered even in paediatric patients. However, compared to adult patients, the clinical manifestation and course of the disease in children may differ. We present a case report of a 13-year-old boy admitted to our department with a history of abdominal pain, weight loss, vomiting, and sudden development of jaundice. Initial laboratory parameters showed signs of cholestasis, inflammatory parameters and pancreatic enzymes were in the normal range. ERCP examination demonstrated stenosis of the pancreat

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Lee, Yi-Chieh, Hsueh-Yu Li, and Wan-Ni Lin. "Isolated Epiglottic Manifestations of HIV Infection: Two Cases Reports." Microorganisms 10, no. 12 (2022): 2404. http://dx.doi.org/10.3390/microorganisms10122404.

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Diagnosis of the Human Immunodeficiency Virus (HIV) remains challenging due to non-specific clinical presentations and mostly flu-like symptoms, e.g., fever, headache, sore throat, and general weakness. Oral lesions, such as oral candidiasis and Kaposi sarcoma, are also frequently associated with HIV infection, whereas laryngeal manifestations are rare. We report two cases of newly diagnosed HIV patients with clinical presentations of sore throat, and endoscopy revealed an epiglottic ulcerative tumor-like lesion. A laryngomicrosurgical biopsy of the lesions was performed for persistent symptom

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Karaca Ural, Zeynep, Merve Hatun Erkayman, Zeynep Utlu, Handan Bilen, and Özgür Yörük. "Endoscopic Findings of Mucosal Pemphigus Vulgaris: Clinical Correlation and Diagnostic Value." Dermatology Practical & Conceptual 15 (July 9, 2025): 5870. https://doi.org/10.5826/dpc.1503a5870.

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Background: Pemphigus vulgaris (PV) is an autoimmune bullous disease that usually starts on the oral mucosa but it can affect all mucosal surfaces. There is limited data about endoscopic otorhinolaryngological examination of patients with PV. Objective: To assess the prevalence of nasal, pharyngeal, and laryngeal involvement in patients with PV and to determine its correlation with clinical symptoms. Methods: Thirty-four patients with pemphigus vulgaris were questioned for rhinorrhea, epistaxis, hoarseness and throat pain. All patients' nasal, oral, hypopharyngeal and laryngeal mucosa were the

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Reddy, Lankapothu Prem Balaji, Jagadeeshwar Kakumani, B. Srinidhi, and M. Sathish Kumar. "Sensory ganglionopathy and pituitary lesion in systemic lupus erythematosus: A case report and literature review." Romanian Journal of Rheumatology 34, no. 2 (2025): 85–90. https://doi.org/10.37897/rjr.2025.2.2.

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Background. Systemic lupus erythematosus (SLE) rarely manifests as sensory ganglionopathy or pituitary lesions, posing diagnostic challenges due to their atypical presentations and potential for irreversible damage. Case presentation. A 26-year-old male presented with five months of gait instability, numbness, and hand clumsiness, along with dry eyes and loose stools. Examination revealed sensory ataxia, absent reflexes, and positive anti-dsDNA antibodies, confirming SLE. Nerve conduction studies showed absent sensory nerve action potentials, consistent with sensory ganglionopathy. MRI identif

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Lunge, Snehal, Pallavi Singh, and Arvind Rajbhog Ashwin. "Paraneoplastic pemphigus: Diagnosing with a modified criteria – A case report." Our Dermatology Online 14, e (2023): e15-e15. http://dx.doi.org/10.7241/ourd.2023e.15.

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Paraneoplastic pemphigus is a rare autoimmune blistering disorder which presents with polymorphous cutaneous lesions and recalcitrant stomatitis. The disorder has a 100% association with an underlying neoplasia, primarily lymphoproliferative disorders. We report a patient who presented with oral mucosal lesions resistant to treatment with bullous cutaneous lesion and an underlying NHL-B cell lymphoma. The condition since its inception has been diagnosed using the criteria by Anhalt et al, which still is the most standard one. The criterion has been revised and updated every now and then. A cur

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Priyanka Kumawat and Rajshree Unadkat. "Ayurveda management of Oral Lichen Planus." Journal of Ayurveda and Integrated Medical Sciences 9, no. 8 (2024): 262–67. http://dx.doi.org/10.21760/jaims.9.8.40.

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Background: Oral Lichen Planus (OLP) is a chronic inflammatory disease that affects the mucus membrane of the oral cavity. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+ T cells trigger apoptosis of the basal cells of the oral epithelium. It is characterized by lesions consisting of radiating white, gray, velvety, thread-like papules in a linear, annular and retiform arrangement forming typical lacy, reticular patches, rings and streakes. Although the exact etiology of this disease is still unknown, but some factors are associated with it like dental materials, autoimmu

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Oliveira, Sara, and Inês Gonçalves da Costa. "From a mosquito bite to neonatal lupus: primary care initial diagnosis and multidisciplinary evaluation (case report)." Revista Portuguesa de Clínica Geral 40, no. 6 (2024): 596–601. https://doi.org/10.32385/rpmgf.v40i6.13910.

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Introduction: This clinical case demonstrates that a common lesion like an insect bite can often be much more than it appears. It also illustrates the approach taken to pathology. Case description: This case report describes a newborn who, on the 10th day of life, developed skin lesions with characteristics resembling insect bites. Three weeks later, at 45 days of life, the lesions progressed in size and dimension, leading to an urgent referral to Dermatology. The infant was admitted for a differential diagnosis, undergoing several studies, including skin biopsies and autoimmune studies. The m

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Nidhi Ojha and Om Prakash Yadav. "Benign Mucous Membrane Pemphigoid: A Case Report." International Healthcare Research Journal 4, no. 2 (2020): 34–37. http://dx.doi.org/10.26440/ihrj/0402.05333.

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Benign Mucous Membrane Pemphigoid (MMP) is a vesiculobullous (VB) lesion that affects oral and nasal mucosa, oropharynx, conjunctiva, and genital mucosa. It is considered an autoimmune disease. Autoantibodies are produced due to several external factors or genetic factors. It creates many complications, such as defects in vision, voice alteration (hoarseness), airway obstruction, and dyspareunia. The subepithelial blisters form due to these antibodies. Treatment modalities differ from topical steroids to systemic steroid therapy based on the nature and severity of clinical symptoms.

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Robinson, Carly J., Neil K. Jairath, Jon C. Davis, and Hongyu H. Yang. "A rare case of infliximab induced myeloperoxidase-cytoplasmic antineutrophil cytoplasmic autoantibody positive cutaneous vasculitis." International Journal of Research in Dermatology 8, no. 6 (2022): 574. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20222730.

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<p>Drug-induced cutaneous vasculitis is a known autoimmune complication of tumor necrosis factor (TNF) inhibitors with many instances resulting in the production of newly formed antibodies. We report a 21-year-old female with a past medical history of Crohn’s disease controlled with infliximab who presented to dermatology with a purpuric rash and crusted plaques of her distal lower extremities. Biopsy of a lesion revealed perivascular lymphocytes, neutrophils and eosinophils, vessel wall damage, and dermal eosinophils consistent with a drug-induced vasculitis. Follow up labs assessing fo

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Abbas, Zaheer, Zahra Safaie Naraghi, and Elham Behrangi. "Pemphigus Vulgaris Presented with Cheilitis." Case Reports in Dermatological Medicine 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/147197.

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Background. Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. In 50 to 70% of cases, the initial manifestations of pemphigus vulgaris are oral lesions which may be followed by skin lesions. But it is unusual for the disease to present with initial and solitary persistent lower lip lesions without progression to any other location.Main Observations. We report a 41-year-old woman with dry crusted lesions only on the lower lip, clinically resembling actinic cheilitis and erosive lichen planus, but histopathological evaluation showed unexpected results

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KH, KAMILOV, R. IBRAGIMOVA M. KH., ABDUVAKHOBOVA D.A., and ADILKHODZHAYEVA Z. KH. "MICROBIOLOGICAL CHARACTERISTICS OF THE ORAL MUCOSAIN PATIENTS WITH LICHEN PLANUS ERYTHEMATOSUS." International Journal of Medical Science and Dental Health 10, no. 10 (2024): 01–08. http://dx.doi.org/10.55640/ijmsdh-10-10-01.

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Lichen planus is a multifactorial disease that involves immune, neuroendocrine, microbiological, and other metabolic processes associated with skin and mucosal damage. The microflora of the oral cavity in CPL SOPR was studied by E. S. Leontieva etal., 2014, the microbiocenosis of various biotopes of the oral cavity in patients with CPL SOPR was studied. The study involved 95 patients with CPL SOPR, who underwent hygienic, periodontal and microbiological research methods. The results of the degree of bacterial contamination indicate a more pronounced colonization of foci of CPL lesion by repres

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Raybaud, H., C. V. Olivieri, L. Lupi-Pegurier, et al. "Epstein-Barr Virus–Infected Plasma Cells Infiltrate Erosive Oral Lichen Planus." Journal of Dental Research 97, no. 13 (2018): 1494–500. http://dx.doi.org/10.1177/0022034518788282.

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Epstein-Barr virus (EBV), in addition to its transforming properties, contributes to the pathogenesis of several inflammatory diseases. Here, we investigated its involvement in oral lichen planus (OLP), a common autoimmune-like disease of unknown etiopathogenesis that can display a malignant potential. EBV-infected cells (EBV+ cells) were sought in a large series of clinically representative OLPs ( n = 99) through in situ hybridization to detect small noncoding EBV-encoded RNAs. Overall, our results demonstrated that EBV was commonly found in OLP (74%), with significantly higher frequency (83%

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Fatima, Reem, Muhammad Adeel Siddiqui, and Hassan Ejaz. "Comparison between Tab Tofacitinib and Low-Dose Oral Steroid in Patients Having Vitiligo Over 6 Months." Journal of Health and Rehabilitation Research 4, no. 1 (2024): 917–21. http://dx.doi.org/10.61919/jhrr.v4i1.485.

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Background: Vitiligo is a chronic autoimmune condition characterized by depigmented patches on the skin, presenting significant treatment challenges. Recent studies have focused on the immunomodulatory effects of tofacitinib, a Janus kinase inhibitor, and the anti-inflammatory properties of low-dose oral steroids, yet comparative data on their efficacy and safety are scarce. Objective: The aim of this study was to compare the efficacy and safety of tofacitinib tablets with low-dose oral steroids in the treatment of vitiligo over a six-month period. Methods: This descriptive comparative study i

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Kara Polat, Asude, Mehmet Kamil Mülayim, Tuğba Falay Gür, et al. "Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal İnvolvement: A Multicenter Observational Study." Dermatology Practical & Conceptual 14, no. 2 (2024): e2024099. http://dx.doi.org/10.5826/dpc.1402a99.

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Introduction: Pemphigus vulgaris (PV) is an autoimmune disease that mostly affects the oral mucosa. Objectives: This study aimed to determine the demographic, clinical and treatment characteristics as well as the quality of life of patients with PV and oral mucosal involvement. Methods: We conducted a prospective observational study among 106 patients with PV and oral mucosal involvement. Demographic data, clinical and treatment characteristics, and quality of life questionnaires were recorded. Results: Of the 106 patients, 51.89% were males. Mucocutaneous subtype was found in 78.38% of the pa

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Tiwary, Pankaj Kumar, Md Mobarak Hussain, and Anupama Singh. "Role of intralesional platelet-rich plasma (PRP) therapy in the treatment of recalcitrant oral ulcers of pemphigus vulgaris." IP Indian Journal of Clinical and Experimental Dermatology 10, no. 4 (2024): 442–47. http://dx.doi.org/10.18231/j.ijced.2024.077.

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Pemphigus Vulgaris is a chronic, autoimmune vesiculobullous disorder in which 80-90% of patients develop oral lesions and in 60% of cases, oral lesions are the first sign. The platelet-rich concentrate present in autologous platelet-rich plasma (PRP) therapy has a high concentration of growth factors that promote the synthesis of collagen and extracellular matrix. The wound healing property of PRP can be used to treat recalcitrant oral ulcers of pemphigus as it accelerates the healing process, prevents the patients from side effects of steroids, and reduces the pain and discomfort of the patie

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Sukekava, Flavia, Luiz Carlos Carmo Filho, Julia Helena Luiz, and Jaques Luiz. "Utilização do Blue®m no tratamento do líquen plano oral – relato de caso." Full Dentistry in Science 12, no. 46 (2021): 44–48. http://dx.doi.org/10.24077/2021;1246-cj4448.

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Oral lichen planus (OLP) is an autoimmune disease, one of the most prevalent in the mouth, which mainly affects women, leukoderma, between the third and sixth decades of life. Of unknown etiology, it may present with bilateral/symmetrical lesions, occurring throughout the mouth. The clinical characteristics range from white keratotic lesions to painful erosions and ulcerations, with reticular, atrophic, papular, erosive, bullous, and erythematous forms, depending on the time of evolution and location. Oxygen-releasing products are gaining ground in the dental market with the promise of aid in

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Kohli, Sahil. "Various Treatment Modalities of Oral Lichen Planus: A Concise Review." International Journal of Research and Review 11, no. 6 (2024): 35–40. http://dx.doi.org/10.52403/ijrr.20240605.

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Oral Lichen Planus (OLP) is an autoimmune, mucocutaneous disorder present in the oral cavity. Besides oral mucosa, skin, scalp and genital mucosa can also get affected. Middle aged females are mostly affected. It is a precancerous lesion and its atrophic and erosive forms are painful. The patient can experience burning sensation and discomfort in such cases. It is chronic inflammatory disorder and it mostly affects adults. Cytotoxic T cells play an important role in its pathogenesis. This disorder is also triggered by viral and bacterial infections. The treatment plan aims in reducing the infl

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Temnikova, Elena A., Anna V. Chekina, and Kira V. Vetkova. "Clinical Case Therapeutic consultation a patient with damage to the oral mucosa from the dentist. When, why, about what?" Clinical review for general practice 5, no. 1 (2024): 78–82. http://dx.doi.org/10.47407/kr2023.5.1.00365.

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Oral mucosal pathology is a significant problem in stomatology due to the complexity of a differential diagnosis and often requires the systemic therapy of it. Therefore, it is not uncommon for patients with diseases of the oral mucosa to be referred to a therapeutic physician to find the etiological factor of oral mucosa disease and to choose the systemic therapy. However, the purpose of the consultation and the capacity of the therapist’s physician in such situations may be interpreted differently by stomatologists and therapists. There is an example of the patient with lichen planus. The ma

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Arellano, Janetta, and Michael Sy. "Treatment-Refractory Autoimmune Glial Fibrillary Acidic Protein Meningoencephalomyelitis in a Young Adult Female." Neurology 99, no. 23 Supplement 2 (2022): S55.1—S55. http://dx.doi.org/10.1212/01.wnl.0000903444.16135.69.

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ObjectiveTo describe a case of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy refractory to immunotherapy without evidence of malignancy or coexisting autoimmunity.BackgroundAutoimmune GFAP astrocytopathy is an autoimmune disease of the central nervous system associated with the presence of GFAP-IgG in the CSF. Patients may present with acute or subacute onset of headache, encephalopathy, seizures, abnormal vision, weakness or numbness, postural tremor and cerebellar ataxia. GFAP astrocytopathy is usually corticocorticosteroid-responsive in the acute setting but may rarely re

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Iuliano, Stefano, Maria Carmela Zagari, Margherita Vergine, et al. "Autoimmune Hypophysitis with Late Renal Involvement: A Case Report." Endocrines 2, no. 2 (2021): 160–66. http://dx.doi.org/10.3390/endocrines2020016.

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We report a case of a 50-year-old male admitted to the Endocrinology Unit because of persistent headaches, nausea, feeling tired, sudden weight loss, cold intolerance, decreased appetite, and lack of sex interest. Diagnostic workup showed a 6-millimeter pituitary tumor without signs of compression, and a condition of progressive panhypopituitarism. After 12 months of hormone replacement therapy, the patient was hospitalized because of sudden weight gain, periorbital-peripheral edema, severe dyslipidemia, hypertension, and proteinuria. Corticosteroid therapy was shifted from oral to continuous

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Baby, Tibin K., P. R. Bindhu, Rekha Krishna Pillai, and P. Jayanthi. "Immunohistochemical expression of cyclooxygenase-2 in oral lichen planus and normal oral mucosa." Indian Journal of Pathology and Microbiology 65, no. 1 (2022): 8–12. http://dx.doi.org/10.4103/ijpm.ijpm_1304_20.

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Background: Oral lichen planus (OLP) is a chronic inflammatory disease for which the pathogenesis is complex and not fully understood; autoimmunity has been suggested as a causative factor. World health organization (WHO) has classified OLP as a potentially malignant lesion. Cyclooxygenase-2 (COX-2) is an inducible key enzyme that generates prostanoids which play a critical role in inflammation, immunopathology; also considered as a malignant potential marker. Aims: The present study was conducted to analyze and compare epithelial COX-2 expression in OLP clinical subtypes and normal oral mucos

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Guryevskaya, Olga, Irina Usmanova, Zuhra Hismatullina, et al. "CLINICAL MANIFESTATIONS OF ORAL MUCOSAL LESIONS IN VERIOUS DERMATOSIS." Actual problems in dentistry 16, no. 1 (2020): 5–13. http://dx.doi.org/10.18481/2077-7566-20-16-1-5-13.

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Subject. This review presents a modern literature review on the clinical manifestations of severe autoimmune disease — pemphigus vulgaris, chronic genetic determinate dermatosis — by the example of epidermolysis bullosa, dermatosis — lichen planus, acute immuno-mediated disease — multiforme exudative erythema. The goal is to conduct a systematic analysis of modern domestic and foreign literature to determine some features of the clinical manifestations of chronic dermatoses with lesions of the oral mucosa. Methodology. A review of the studies allows us to consider the etiology and

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