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Articles de revues sur le sujet « Bi-layered Tablet of Divalproex Sodium »

Auteur : Grafiati
Publié le 2 juin 2025
Mis à jour le 31 juillet 2025

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1

RAJPUT, RAJVEER SINGH, and BALA KUMAR CHANDRASEKARAN. "FORMULATION AND IN VITRO EVALUATION OF DIVALPROEX SODIUM BI-LAYERED TABLET." Current Research in Pharmaceutical Sciences 12, no. 3 (2022): 138–46. http://dx.doi.org/10.24092/crps.2022.120303.

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Divalproex sodium is the anticonvulsant agents that used in the treatment certain types of seizures. The aim of the present study is to formulate and evaluate divalproex sodium bilayer tablet. Divalproex Sodium Bi-layer tablets (BLT) were prepared by simple blending and punching with HPMC, Xanthan Gum, Sodium starch glycolate, MCC, PVP, and Magnesium stearate. Optimized formulation was designed on the basis of best formulation of the immediate release layer and sustained release layer. The pre and post compression parameters were evaluated and stability studies of the optimized formulation was
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Acharya, Ankit, Mohammed Gulzar Ahmed, Ravi Chaudhari, and Renukaradhya Chitti. "Formulation and Development of Divalproex Sodium Bi-Layered Tablets using Superdisintegrants and Release Retardant Polymers." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 2 (2017): 3669–75. http://dx.doi.org/10.37285/ijpsn.2017.10.2.5.

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 Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. The present work has been done to formulate bi-layered tablet of Divalproex sodium containing immediate release layer and sustained release layer. The FTIR study revealed that there was no interaction between drug and polymer and combination. Both layers were prepared by wet granulation technique as poor flow property exhibited by pure drug. The immediate release layer was formulated by using superdisintegrants and evaluat
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Agam, Kumar Chaubey* Ashok Baghel Dinesh Sharma Yogendra Singh. "Formulation And Evaluation of Bi-Layered Tablet of Divalproex Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 501–13. https://doi.org/10.5281/zenodo.14993024.

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The pharmacokinetic advantage relies on the criterion that, drug release from the fast-releasing layer leads to a sudden rise in the blood concentration. However, the blood level is maintained at steady state as the release from sustained layer. Particularly bilayer tablets are commonly used to avoid chemical incompatibilities of formulation components by physical separation, and release profile. The tablet is the most widely used dosage form because of its convenience in terms of self-administration, compactness and ease in manufacturing.4 Tablets are solid dosage forms containing medicinal s
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Saniya, Mubarik*1 Rajni Dubey2 Bhaskar Kumar Gupta3 Mariya Beg4. "A Research Article: Formulation and Evaluation of By-Layered Tablet of Divalproex Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2797–809. https://doi.org/10.5281/zenodo.15099861.

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Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. The present work has been done to formulate bi-layered tablet of Divalproex sodium containing immediate release layer and sustained release layer. The FTIR study revealed that there was no interaction between drug and polymer and combination can be safely prepared. Both layers were prepared by wet granulation technique as poor flow property exhibited by pure drug. The immediate release layer was formulated by using sodium starch
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Gunda, Dr Raghavendra Kumar, and Dr Tirumala Devi Kolli. "DEVELOPMENT AND IN-VITRO ASSESSMENT OF DIVALPROEX SODIUM BILAYERED TABLETS." Journal of Applied Pharmaceutical Sciences and Research 7, no. 2 (2024): 46–52. http://dx.doi.org/10.31069/japsr.v7i2.08.

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Objective: The aim of the current research work is to develop a bi-layered Divalproex sodium tablet with an immediate release layer and a sustained release layer. Divalproex sodium is regarded as the most significant antiepileptic medication and is frequently used to treat bipolar illness, epilepsy, and migraine prevention. Methods: Wet granulation was used to prepare both (Immediate release, Sustained release) layers since Divalproex had poor flow properties. Superdisintegrants were used to produce the immediate release layer, which was then assessed for physical characteristics, disintegrati
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Salve, Bhumika* Zanjad Aniket Deshmukh Komal Kalamkar Tejas. "A Review on Formulation and Evaluation of BI- Layered Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4527–36. https://doi.org/10.5281/zenodo.15535200.

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In order to achieve biphasic drug administration, the current review concentrates on the formulation and assessment of a 100 mg bi layered tablet of Divalproex Sodium that combines immediate release (IR) and sustained release (SR) components. A stable combination of sodium valproate and valproic acid, divalproex sodium is used extensively to treat epilepsy, bipolar disorder, and migraine prevention. But because of its brief half-life, frequent administration is required, which may result in noncompliance from patients. An efficient method to get around these restrictions is to use a bilayer pi
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Mabuchan, Shaik, and Jagadeesh Babu B. "Formulation and Evaluation of Bi-Layered Tablet of Divalproex Sodium." Asian Journal of Medical and Pharmaceutical Sciences 12, no. 1 (2024): 34–40. http://dx.doi.org/10.30904/j.ajmps.2024.4657.

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Khan, Arib, Satkar Prasad, and Gaurav Dubey. "Formulation and evaluation of bi-layered tablet of divalproex sodium." Journal of Pharmacognosy and Phytochemistry 12, no. 2 (2023): 16–22. http://dx.doi.org/10.22271/phyto.2023.v12.i2a.14621.

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Jatav, Pooja, Ashok Baghel, and Dinesh Sharma. "Formulation and evaluation of bi-layered tablet of divalproex sodium." International Journal of Pharmacy and Pharmaceutical Science 7, no. 1 (2025): 19–25. https://doi.org/10.33545/26647222.2025.v7.i1a.146.

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Elmostafa Kamil Khalil Abbas. "Optimization and appraisal of Bi-layered tablets containing divalproex sodium to augment therapeutic effectiveness." International Journal of Science and Research Archive 15, no. 3 (2025): 006–7. https://doi.org/10.30574/ijsra.2025.15.3.1652.

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The current study aimed to optimize and evaluate bi-layered tablets of Divalproex Sodium designed for improved therapeutic effectiveness in the treatment of epilepsy, bipolar disorder, and migraine. The formulation combined an immediate release (IR) layer with a sustained release (SR) layer to ensure rapid onset and prolonged action. Compatibility studies confirmed no significant interaction between the drug and excipients. Evaluation of pre- and post-compression parameters including hardness, friability, drug content, and in vitro dissolution studies demonstrated desirable characteristics. Th
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Kamal, Kamal Kant, Ashutosh Sharma, Mayank Bansal, and Vishal Choudhary. "Design and evaluation of bi-layered tablet of Ramipril and hydrochlorothiazide for the Treatment of hypertension." Journal of Biomedical and Pharmaceutical Research 14, no. 3 (2025): 38–41. https://doi.org/10.32553/jbpr.v14i3.1320.

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Hypertension is a widespread cardiovascular disease that requires effective management through combination therapy. The complexity of hypertension necessitates a multifaceted approach, often involving the concurrent administration of multiple antihypertensive agents. This study aims to design, formulate, and evaluate bi-layered tablets of Ramipril and Hydrochlorothiazide, leveraging the benefits of sequential drug release and stability enhancement. The bi-layer tablet formulation comprises an immediate-release layer for rapid therapeutic onset and a sustained-release layer for prolonged plasma
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Vasoya, Ankur, Sunil Kumar Shah, C. K. Tyagi, Prabhakar Budholiya, and Harish Pandey. "Formulation, Development and Evaluation of Chewable Bi-layered Tablets for Treating Gastro Esophageal Reflux Disease." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 92–99. http://dx.doi.org/10.22270/jddt.v10i4-s.4224.

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The purpose of this research work was to formulate raft-forming chewable bilayer tablets of sodium alginate using a raft-forming agent along with gas-generating agents. Tablets were prepared by wet granulation and evaluated for raft strength, acid neutralization capacity, weight variation, % drug content, thickness, hardness, friability and in vitro drug release. Various raft-forming agents were used in preliminary screening. The amount of sodium alginate, amount of calcium carbonate and amount sodium bicarbonate were selected as variables. Raft strength, acid neutralization capacity and drug
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Madhu, Rajak*, Amal Raj A., Singh Dhakad Rajendra, and Singh Rajput Hakim. "FORMULATION AND EVALUATION OF BILAYER TABLET OF ANTIHYPERTENSIVE DRUG." World Journal of Pharmaceutical Science and Research 3, no. 5 (2024): 440–53. https://doi.org/10.5281/zenodo.14050790.

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The aim of present study is to prepare bilayer tablets of Losartan Potassium with an immediate release and a sustained release layer. The immediate release layer was prepared using super disintegrant sodium starch glycolate and sustained release layer is formulated with different polymers. The bilayer tablets of losartan potassium were prepared by the direct compression method. The drug, polymers and other excipients used for both immediate (IR) and sustained release (SR) layers were passed through sieve #80 before their use in the formulation. The immediate dose of drug was calculated from to
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Mr., Panthalarasa S., and S. Chandra Dr. "DESIGN AND EVALUATION OF BILAYERED TABLET CONTAINING DIVALPROEX SODIUM." June 7, 2025. https://doi.org/10.5281/zenodo.14632012.

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The objective of the study is to design and evaluate bi-layered tablet of Divalproex sodium containing immediate release layer and sustained release layer. Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. The FTIR study revealed that there was no interaction between drug and polymer and combination can be safely prepared. Both layers were prepared by wet granulation technique as poor flow property exhibited by pure drug. The immediate release layer was formulated by using sodiu
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Sreedhar, Ranjan Das Bibhuti Bhusan Panigrahi and Manoj Kumar.Pani. "PREPARATION AND IN VITRO EVALUATION OF OPTIMIZED FORMULATION OF BI- LAYERED FLOATING TABLET OF SUCRALFATE AND METOPROLOL SUCCINATE." May 25, 2019. https://doi.org/10.5281/zenodo.3273921.

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Objective: The present study based upon the preparation and in vitro evaluation of optimized Bi layered floating tablet (OSFMS)having tablet weight of 400 mg.(214.88 mgofsucralfate& 186 mg of Metoprol succinate). Method: Selection of the formulation, pre compression study, preparation of tablet and in vitro evaluation of tablet. Result: In presence of Lactose MFL, MCC PH 101, Sodium Bicarbonate, Polysorbate 80, Cross povidone of majore amount in Sucralfate layer and in presence of HPMC K 100 M, Sodium Bicarbonate, Eudragit RSPO, Na CMC ,Sodium alginate, HPC, Ethyl Cellulose of majore amoun
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Sreedhar, Ranjan Das Bibhuti Bhusan Panigrahi And Manoj Kumar Pani. "DEVELOPMENT AND OPTIMIZATION OF BI LAYERED FLOATING TABLET OF SUCRALFATE AND METOPROLOL SUCCINATE." May 25, 2019. https://doi.org/10.5281/zenodo.3273878.

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Objective:To optimize and develop Bi layered floating tablet (SFMS) containing ulcer protective Sucralfate as immediate release layer and anti hypertensiveMetoprolol Succinate as sustained release layer. Method: 15 formulations of Sucralfate and 10 formulations of Metoprolol Succinate is taken. By changing the concentration of Superdisintigrant, Surfectants, Alkalizing agents & Binding agents of Sucralfate and changing concentrations of Alkalizing agents and Polymers of Metoprolol Succinate the OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) is generated.. Result: Within
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Gawai, Snehal, Nilakshi Dhoble, Priyanka Mandal, Nitin Padole, and Pankaj Dhapake. "Development and Evaluation of bi-layer Tablet Containing Sustained-Release and Immediate Release Celecoxib." Research Journal of Pharmacy and Technology, December 27, 2024, 5915–22. https://doi.org/10.52711/0974-360x.2024.00897.

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The purpose of this study is to prepare a bilayer tablet of Celecoxib using wet granulation technology and to formulate an optimized formulation. Celecoxib is a non-steroidal anti-inflammatory drug that inhibits the prostaglandin-generating enzyme cyclo-oxygenase 2 and reduces the pain and inflammation of Osteoarthritis. Fast release of the drug from the immediate-release layer can give a rapid onset of action which will help to reduce pain and inflammation within a short period while the maintenance dose of Celecoxib will maintain plasma concentration within the therapeutic range for 24 hours
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