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Articles de revues sur le sujet « Biochemical markers of transformation »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Lindström-Seppä, Pirjo, Katalin Urban, Ulla Honkalampi-Hämäläinen, and Sashwati Roy. "Biochemical Responses in Aquatic Plants as Markers of Environmental Contamination." Alternatives to Laboratory Animals 29, no. 3 (2001): 277–82. http://dx.doi.org/10.1177/026119290102900312.

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This short review gives several examples of the current status of xenobiotic bio-transformation reactions and oxidative stress responses in plants as biomarkers of organic pollution in aquatic environments. Based on previous basic knowledge, several biomonitoring programmes have been successfully applied during the last decade.

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Havelková, Marcela, Tomáš Randák, Jana Blahová, Iveta Slatinská, and Zdeňka Svobodová. "Biochemical markers for the assessment of aquatic environment contamination." Interdisciplinary Toxicology 1, no. 2 (2008): 169–81. http://dx.doi.org/10.2478/v10102-010-0034-y.

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Biochemical markers for the assessment of aquatic environment contaminationThe need for assessment of aquatic ecosystem contamination and of its impact on water dwelling organisms was developed in response to rising aquatic environmental pollution. In this field study, liver enzymes of phase I and phase II of xenobiotic transformation, namely cytochrome P450, ethoxyresorufin-O-deethylase, glutathione-S-transferase and tripeptide glutathione were used to assess the contamination of the aquatic environment at different rivers in the Czech Republic. The indicator species selected was the male chu

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Bates, P. A. "Complete developmental cycle ofLeishmania mexicanain axenic culture." Parasitology 108, no. 1 (1994): 1–9. http://dx.doi.org/10.1017/s0031182000078458.

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SUMMARYA complete developmental sequence ofLeishmania mexicanahas been produced in axenic culture for the first time. This was achieved by manipulation of media, pH and temperature conditions over a period of 16 days. All experiments were initiated with lesion amastigotes that were transformed to multiplicative promastigotes by culture in HOMEM, 10% foetal calf serum, pH 7·5, at 25 °C. Metacyclogenesis was induced by subpassage in Schneider'sDrosophila medium, 20% foetal calf serum, pH 5·5, and the resulting forms transformed to axenically growing amastigotes by subpassage in the same medium a

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Coradduzza, Donatella, Leonardo Sibono, Alessandro Tedde, et al. "Diagnostic Stratification of Prostate Cancer Through Blood-Based Biochemical and Inflammatory Markers." Diagnostics 15, no. 11 (2025): 1385. https://doi.org/10.3390/diagnostics15111385.

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Background: Prostate cancer (PCa) remains one of the most prevalent malignancies in men, with diagnostic challenges arising from the limited specificity of current biomarkers, like PSA. Improved stratification tools are essential to reduce overdiagnosis and guide personalized patient management. Objective: This study aimed to identify and validate clinical and hematological biomarkers capable of differentiating PCa from benign prostatic hyperplasia (BPH) and precancerous lesions (PL) using univariate and multivariate statistical methods. Methods: In a cohort of 514 patients with suspected PCa,

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Desjardins, M., LA Huber, RG Parton, and G. Griffiths. "Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus." Journal of Cell Biology 124, no. 5 (1994): 677–88. http://dx.doi.org/10.1083/jcb.124.5.677.

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We have examined the modifications occurring during the transformation of phagosomes into phagolysosomes in J-774 macrophages. The use of low density latex beads as markers of phagosomes (latex bead compartments, LBC) allowed the isolation of these organelles by flotation on a simple sucrose gradient. Two-dimensional gel electrophoresis, immunocytochemistry, and biochemical assays have been used to characterize the composition of LBC at different time points after their formation, as well as their interactions with the organelles of the endocytic pathway. Our results show that LBC acquire and

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Kolgi, Rajeev Ramachandra, Bhargavi G, Nataraju Angaswamy, M. V. Srinivasulu, and S. Shankara Somashetty. "A Short Review - Biochemical Aspects and Advancements in Gastric Cancer." Biosciences Biotechnology Research Asia 21, no. 1 (2024): 69–79. http://dx.doi.org/10.13005/bbra/3203.

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ABSTRACT: Malignancy in the stomach is one of the silent causes of mortality due to a bad prognosis regardless of gender. It is the world's Fourth leading cause of death It is a disorder in which cancerous cells form in the stomach lining. The primary relationships begin between its carcinogenic route and Helicobacter pylori infection, following inflammation, and tissue regeneration. The review aims to evaluate biochemistry related to gastric cancer which focuses on cancer research including etiology, molecular basis, malignant transformation, tumor markers, prognosis, advancements in gastric

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Alves, Adriana Cristina, Vera Maria Quecini, and Maria Lucia Carneiro Vieira. "PLANT TRANSFORMATION: ADVANCES AND PERSPECTIVES." Scientia Agricola 56, no. 1 (1999): 1–8. http://dx.doi.org/10.1590/s0103-90161999000100001.

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Genetic transformation is a powerful tool for plant breeding and genetical, physiological or biochemical research, consequently it is an extremely dynamic field. Transgenic plants are commonly used to complete or substitute mutants in basic research, helping the studies of complex biological situations such as pathogenesis process, genome organization, light reception and signal transduction. In this review, recent approaches for foreign gene introduction (e.g. Agrobiolistics, whole tissue electroporation, in planta Agrobacterium transformation), screening (reporter gene possibilities and perf

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Maitra, Ishaan, Camilo L. M. Morais, Kássio M. G. Lima, et al. "Attenuated Total Reflection Fourier-Transform Infrared Spectral Discrimination in Human Tissue of Oesophageal Transformation to Adenocarcinoma." Journal of Personalized Medicine 13, no. 8 (2023): 1277. http://dx.doi.org/10.3390/jpm13081277.

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This study presents ATR-FTIR (attenuated total reflectance Fourier-transform infrared) spectral analysis of ex vivo oesophageal tissue including all classifications to oesophageal adenocarcinoma (OAC). The article adds further validation to previous human tissue studies identifying the potential for ATR-FTIR spectroscopy in differentiating among all classes of oesophageal transformation to OAC. Tissue spectral analysis used principal component analysis quadratic discriminant analysis (PCA-QDA), successive projection algorithm quadratic discriminant analysis (SPA-QDA), and genetic algorithm qua

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Jia, Dan, Siqi Jin, Jin Zhang, et al. "Dynamic Changes in Metabolites and Transformation Pathways in Diqing Tibetan Pig Hams During Fermentation Determined by Widely Targeted Metabolomic Analysis." Foods 14, no. 14 (2025): 2468. https://doi.org/10.3390/foods14142468.

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This study investigated the metabolite dynamic changes and transformation pathways in Diqing Tibetan pig (DTP) hams during fermentation (0, 30, 90, 180, 360, 540 d) by widely targeted metabolomics. A total of 873 metabolites in 17 subclasses were detected, with significant changes in 448 metabolites. Additionally, 65 key metabolites were found to be involved in the top 10 pathways, with the top pathways for metabolite markers in mature hams including protein metabolism (2-oxocarboxylic acid metabolism, tryptophan metabolism and amino acid biosynthesis) and lipid metabolism (unsaturated fatty a

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Djukic, Vojko, Ljiljana Janosevic, Milovan Dimitrijevic, Svetozar Damjanovic, Predrag Pesko, and Jelena Dotlic. "Genetic markers for head and neck cancers: Current state of art and perspectives." Jugoslovenska medicinska biohemija 22, no. 4 (2003): 273–82. http://dx.doi.org/10.2298/jmh0304273d.

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This article analyzes the genetic markers of planocellular head and neck cancers from the aspect of theoretical basis for their identification and application, actual state of research in this field and benefit that could be expected from their introduction into clinical practice. In spite of unquestionable progress of diagnostics and treatment of planocellular cancer of the head and neck, there has been no evident improvement of five-year survival during the last two decades, due to which the attempts have been made for global diagnostics and therapeutic orientation to be directed towards the

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Adamczyk, Maciej, Srinivasa Rao Akireddy, and Rajarathnam E. Reddy. "Transformation of Vitamin B6 to (+)-Deoxypyridinoline, a useful Biochemical Marker for Diagnosis of Bone Diseases." Tetrahedron 56, no. 16 (2000): 2379–90. http://dx.doi.org/10.1016/s0040-4020(00)00121-6.

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Alonso, Teresa, and Eugenio Santos. "Increased intracellular glycerophosphoinositol is a biochemical marker for transformation by membrane-associated and cytoplasmic oncogenes." Biochemical and Biophysical Research Communications 171, no. 1 (1990): 14–19. http://dx.doi.org/10.1016/0006-291x(90)91349-w.

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Xu, Jing, and Jian Guo. "Markov chain based simulation analysis of bone mineral density and changes in the level of biochemical markers of bone transformation in postmenopausal women." Cluster Computing 22, S2 (2018): 4737–44. http://dx.doi.org/10.1007/s10586-018-2320-y.

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Krachulec, Justyna, Melanie Vetter, Anja Schrade, et al. "GATA4 Is a Critical Regulator of Gonadectomy-Induced Adrenocortical Tumorigenesis in Mice." Endocrinology 153, no. 6 (2012): 2599–611. http://dx.doi.org/10.1210/en.2011-2135.

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In response to gonadectomy certain inbred mouse strains develop sex steroidogenic adrenocortical neoplasms. One of the hallmarks of neoplastic transformation is expression of GATA4, a transcription factor normally present in gonadal but not adrenal steroidogenic cells of the adult mouse. To show that GATA4 directly modulates adrenocortical tumorigenesis and is not merely a marker of gonadal-like differentiation in the neoplasms, we studied mice with germline or conditional loss-of-function mutations in the Gata4 gene. Germline Gata4 haploinsufficiency was associated with attenuated tumor growt

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Dini, Elisa, Sonia Mazzucchi, Ciro De Luca, et al. "Plasma Levels of Oxidative Stress Markers, before and after BoNT/A Treatment, in Chronic Migraine." Toxins 11, no. 10 (2019): 608. http://dx.doi.org/10.3390/toxins11100608.

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The pathophysiological mechanisms of migraine transformation are debated. Modifications of plasma oxidative stress biomarkers have been described in chronic migraine. OnabotulintoxinA (BoNT/A) treatment, approved for chronic migraine prophylaxis, possibly reduces pain neurotransmitters release and oxidative stress products. Aims of our study were to investigate differences in the levels of selected plasmatic oxidative stress biomarkers (Advanced Oxidation Protein Products (AOPP), Ferric Reducing Antioxidant Power (FRAP), Thiolic Groups (SH)) comparing chronic migraineurs (CM) and healthy contr

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Schroeder, D. F., and J. D. McGhee. "Anterior-posterior patterning within the Caenorhabditis elegans endoderm." Development 125, no. 24 (1998): 4877–87. http://dx.doi.org/10.1242/dev.125.24.4877.

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The endoderm of higher organisms is extensively patterned along the anterior/posterior axis. Although the endoderm (gut or E lineage) of the nematode Caenorhabditis elegans appears to be a simple uniform tube, cells in the anterior gut show several molecular and anatomical differences from cells in the posterior gut. In particular, the gut esterase ges-1 gene, which is normally expressed in all cells of the endoderm, is expressed only in the anterior-most gut cells when certain sequences in the ges-1 promoter are deleted. Using such a deleted ges-1 transgene as a biochemical marker of differen

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Langner, Josana A., Alencar J. Zanon, Nereu A. Streck, Lia R. S. Reiniger, Marielen P. Kaufmann, and Alexandre F. Alves. "Maize: Key agricultural crop in food security and sovereignty in a future with water scarcity." Revista Brasileira de Engenharia Agrícola e Ambiental 23, no. 9 (2019): 648–54. http://dx.doi.org/10.1590/1807-1929/agriambi.v23n9p648-654.

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ABSTRACT The objective in this review was to discuss the importance of maize currently and the crucial role it may play in the future for food production in scenarios of water shortage, as well as the importance of conserving its landrace cultivars, which have a considerable portion of the reserve of genetic variability. Maize plants, when exposed to water deficit, may develop physiological, morphological, biochemical and anatomical adaptation mechanisms. With the aid of genetic improvement, characteristics that impart tolerance are fixed in plants through conventional methods. In this context

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Picard, F. J., and J. R. Dillon. "Biochemical and genetic studies with arginine and proline auxotrophs of Neisseria gonorrhoeae." Canadian Journal of Microbiology 35, no. 12 (1989): 1069–75. http://dx.doi.org/10.1139/m89-179.

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The prevalence of specific arginine biosynthesis gene defects was studied for 319 arginine-requiring clinical isolates of Neisseria gonorrhoeae by using the ability of the strains to utilize intermediates of arginine biosynthesis. Only 11 % of the uracil-requiring strains defective in the carbamylation of ornithine to yield citrulline had a defective carbamoylphosphate synthetase gene (carAB). Strains defective in carAB were of auxotype CUH. The other strains (89%) having a dual requirement for citrulline and uracil, which were mostly of auxotype PCU, were defective in the ornithine transcarba

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Halahan, Yu V., O. Ye Maievskyi, Yu Yo Guminskyi, and A. P. Korol. "The effect of hyperhomocysteinemia on the patterns of electron microscopic changes in the liver of adult rats." Biomedical and Biosocial Anthropology, no. 36 (July 10, 2020): 16–21. http://dx.doi.org/10.31393/bba36-2019-03.

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One of the important tasks of modern science is to find biochemical markers that would be able to reflect the risks of development and the nature of the course of various diseases, as well as to predict their possible consequences. In recent years, a significant number of compounds that can affect the biochemical profile of the organism have been identified. Homocysteine – a product of methionine metabolism, belongs to one of these markers, and the effects of its influece on the structure and function of various organs are being actively studied by modern researchers. The aim of the study is t

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Horvat, B., H. A. Multhaupt, and I. Damjanov. "Glycoproteins of mouse vaginal epithelium: differential expression related to estrous cyclicity." Journal of Histochemistry & Cytochemistry 41, no. 9 (1993): 1351–57. http://dx.doi.org/10.1177/41.9.8354876.

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We used lectin overlay blotting and SDS-PAGE to analyze the estrous cycle-specific expression of mouse vaginal epithelial glycoproteins. Seven lectins chosen for their differential carbohydrate-binding specificity revealed 15 glycoproteins that showed cycle-related expression. Each lectin had a unique binding pattern different from the patterns revealed by other lectins. However, several estrous cycle phase-specific glycoproteins reacted with more than one lectin. The most prominent of these glycoproteins (M(r) 92-95 KD) was weakly expressed in late diestrus and fully expressed only in proestr

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Treaster, Sharon, Michael Knee, and Pablo Jourdan. "ADAPTATION OF FAST PLANTS® AS MODEL ORGANISMS FOR HANDS-ON INSTRUCTION OF FUNDAMENTAL CONCEPTS IN HORTICULTURE." HortScience 28, no. 5 (1993): 564f—564. http://dx.doi.org/10.21273/hortsci.28.5.564f.

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The Wisconsin Fast Plants® (rapid cycling forms of Brassica rapa) have become a major educational tool in basic botany, plant physiology and plant genetics courses because of their versatility, ease of manipulation, and short life cycle (40-day generation). Various educational activities already developed by the Fast Plants Network can be incorporated effectively into established horticulture courses. We have been utilizing these plants in some of our introductory courses and have developed additional protocols and materials. Some of the new educational activities utilize the rapid cycling for

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Journal, Baghdad Science. "Estimation of Testosterone, Estradiol and some Markers in Sera of Iraqi Patients with Benign Prostatic Hyperplasia." Baghdad Science Journal 10, no. 4 (2013): 1162–71. http://dx.doi.org/10.21123/bsj.10.4.1162-1171.

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Benign prostatic hyperplasia (BPH) is one of the most common disease and major cause of morbidity in elderly men which may lead to bladder outflow obstruction and lower urinary tract symptoms (LUTS). Although sex steroid hormones play fundamental roles in prostate growth, their clinical significance is not completely clear. In the present study we assessed whether serum hormones levels as markers of prostate disease. This study includes (40) patients with benign prostatic hypertrophy and (40) control group with age rang (41-79) and (42-71) years respectively. The following biochemical investig

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Khaleel, Fayhaa M., Ihsan A. AL-Shammri, and Nour AL-Huda G. Mohammed. "Estimation of Testosterone, Estradiol and some Markers in Sera of Iraqi Patients with Benign Prostatic Hyperplasia." Baghdad Science Journal 10, no. 4 (2013): 1162–71. http://dx.doi.org/10.21123/bsj.2013.10.4.1162-1171.

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Benign prostatic hyperplasia (BPH) is one of the most common disease and major cause of morbidity in elderly men which may lead to bladder outflow obstruction and lower urinary tract symptoms (LUTS). Although sex steroid hormones play fundamental roles in prostate growth, their clinical significance is not completely clear. In the present study we assessed whether serum hormones levels as markers of prostate disease. This study includes (40) patients with benign prostatic hypertrophy and (40) control group with age rang (41-79) and (42-71) years respectively. The following biochemical investig

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Majkic-Singh, Nada. "The choice of the diagnostic biomarkers of acute coronary syndromes." Jugoslovenska medicinska biohemija 24, no. 1 (2005): 1–13. http://dx.doi.org/10.2298/jmh0501001m.

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Cardiac markers have undergone an amazing transformation from asparatate aminotransferase (AST) and lactate dehydrogenase (LDH) to the three cardiac markers families available at present for routine use in Emergency Department for the evaluation of the chest discomfort: myoglobin, creatine kinase (CK) and the MB isoenzyme of CK (CK-MB), and the troponins I and T (cTnI and cTnT). Each of these has well known kinetics of release from dying myocardial cells and should be carefully applied to each patient as directed by timing of symptoms and presentation. Myoglobin has been touted as an early mar

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Gumińska, M., J. Ignacak, T. Kedryna, and M. B. Stachurska. "Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells." Acta Biochimica Polonica 44, no. 4 (1997): 711–24. http://dx.doi.org/10.18388/abp.1997_4373.

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The differences in properties of pyruvate kinase (EC 2.1.7.40) from normal tissues and animal or human tumors are described and their significance for various metabolic abnormalities is reviewed. The tumor variant gamma3 from M2 isoenzyme of pyruvate kinase sensitive to L-cysteine inhibition, when over-expressed, can be used as a marker of tumorigenic transformation. It seems that this variant represents a tumor-specific oncoprotein, involved in a novel metabolic strategy of energy generation during increased cell proliferation.

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Adamczyk, Maciej, Srinivasa Rao Akireddy, and Rajarathnam E. Reddy. "ChemInform Abstract: Transformation of Vitamin B6 to (+)-Deoxypyridinoline, a Useful Biochemical Marker for Diagnosis of Bone Diseases." ChemInform 31, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.200030184.

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Koljančić, Nemanja, Olga Vyviurska, Milica Balaban, and Ivan Špánik. "Determination of biological markers of organic substances in sediment and soil samples by gas chromatography." Acta Chimica Slovaca 13, no. 1 (2020): 34–40. http://dx.doi.org/10.2478/acs-2020-0006.

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AbstractOnce they reach the environment, petroleum hydrocarbons undergo various chemical, physico-chemical and biochemical transformation processes. Organic compounds which are not or are very poorly subject to these processes are thermodynamically the most stable isomers and they are called biological markers (biomarkers). This paper presents the results of the determination of organic substances in twelve samples taken in the area of the city of Banja Luka (Bosnia and Herzegovina). Two soil samples were taken in the Banja Luka city heating plant area and ten river sediment and soil samples w

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Pasechnikova, E. A., V. N. Bodnya, D. V. Kadomtsev, A. Yu Georgieva, V. A. Porhanov, and D. D. Shevchuk. "The epithelial-to-mesenchymal transition in cancer: pathogenetic features." Innovative Medicine of Kuban, no. 2 (June 27, 2022): 85–92. http://dx.doi.org/10.35401/2541-9897-2022-25-2-85-92.

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The epithelial‑to‑mesenchymal transition (EMT) is a cellular biological process, that occurs in a wide range of cells and tissues and is triggered by complex regulatory networks involving transcriptional control with SNAIL, ZEB1, ZEB2, Twist, SLUG, E‑cadherin, vimentin, tumor microenvironment and genetic characteristics. EMT is represented by the multi‑stage development and transformation of cells of the epithelial phenotype into cells that acquire mesenchymal features of various severity. These quasi‑mesenchymal cells are characterized by stemness, tumor heterogeneity, increasing invasiveness

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Wiśniowski, Tomasz, Jarosław Bryda, and Sławomir Wątroba. "The role of matrix metalloproteinases in pathogenesis, diagnostics, and treatment of human prostate cancer." Postępy Higieny i Medycyny Doświadczalnej 77, no. 1 (2023): 9–20. http://dx.doi.org/10.2478/ahem-2023-0002.

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Abstract The prostate gland is highly susceptible to oncogenic transformation, many times more than other sex tissues, such as seminal vesicles. In fact, prostate cancer (PCa) will be diagnosed in one in seven lifetime patients, making PCa the subject of intense research aimed at clarifying its biology and providing adequate treatment. PCa is the fourth most common cancer in the world in terms of the overall population and the second most common cancer for the male population. It is postulated that the development of PCa may be influenced by dietary factors, physical and sexual activity, andro

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Sundström, B. E., and T. I. Stigbrand. "Cytokeratins and Tissue Polypeptide Antigen." International Journal of Biological Markers 9, no. 2 (1994): 102–8. http://dx.doi.org/10.1177/172460089400900207.

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Cytokeratins (CKs), which are biochemically related to intermediate filaments (IFs), form an intracellular network of filaments that is believed to participate in maintaining the structural integrity of cells. Twenty individual polypeptides, divided into two groups, constitute the cytokeratin family. Each type of epithelial cell can be characterized by its content of cytokeratin polypeptides since the expression pattern varies with the type of epithelium. During transformation of normal epithelial cells into malignant cells, the cytokeratin patterns are usually maintained. This property has en

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Lisanti, M. P., P. E. Scherer, J. Vidugiriene, et al. "Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease." Journal of Cell Biology 126, no. 1 (1994): 111–26. http://dx.doi.org/10.1083/jcb.126.1.111.

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Caveolae are 50-100-nm membrane microdomains that represent a subcompartment of the plasma membrane. Previous morphological studies have implicated caveolae in (a) the transcytosis of macromolecules (including LDL and modified LDLs) across capillary endothelial cells, (b) the uptake of small molecules via a process termed potocytosis involving GPI-linked receptor molecules and an unknown anion transport protein, (c) interactions with the actin-based cytoskeleton, and (d) the compartmentalization of certain signaling molecules, including G-protein coupled receptors. Caveolin, a 22-kD integral m

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Kuzniatsou, A. E., V. M. Tsyrkunov, A. V. Shuriberko, O. B. Ostrovskaya, S. S. Kerimova, and O. V. Gorchakova. "BIOCHEMICAL, IMMUNOLOGICAL AND MORPHOLOGICAL CHANGES IN THE LIVER AND LARGE INTESTINE OF RATS AFTER INOCULATION OF DNA/RNA VIRUSES." Hepatology and Gastroenterology 8, no. 2 (2024): 120–30. https://doi.org/10.25298/2616-5546-2024-8-2-120-130.

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Background. A characteristic feature of tumor diseases associated with viruses is a long latent period lasting several years. Objective. To monitor biochemical, immunological and morphological changes in the liver and large intestine after inoculation of Wistar rats with DNA/RNA viruses. Material and methods. The goal was realized on 52 adult male Wistar rats (average initial weight 210.1±14.9 g), on a standard diet and free access to food and water, by inoculating the abdominal cavity with DNA/RNA viruses. The monitoring of biochemical, immunological and morphological parameters reflecting th

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Suarez-Cabrera, Cristian, Isabel Ojeda-Perez, Raquel Sanchez-Baltasar, et al. "ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland." Cancers 13, no. 21 (2021): 5588. http://dx.doi.org/10.3390/cancers13215588.

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ERAS is a relatively uncharacterized gene of the Ras superfamily. It is expressed in ES cells and in the first stages of embryonic development; later on, it is silenced in the majority of cell types and tissues. Although there are several reports showing ERAS expression in tumoral cell lines and human tumor samples, it is unknown if ERAS deregulated expression is enough to drive tumor development. In this report, we have generated transgenic mice expressing ERAS in myoepithelial basal cells of the mammary gland and in basal cells of stratified epithelia. In spite of the low level of ERAS expre

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Zhao, Linjing, Hongbing Wu, Mingfeng Qiu, et al. "Metabolic Signatures of KidneyYangDeficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GC/TOF MS." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/540957.

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KidneyYangDeficiency Syndrome (KDS-Yang), a typical condition in Chinese medicine, shares similar clinical signs of the glucocorticoid withdrawal syndrome. To date, the underlying mechanism of KDS-Yanghas been remained unclear, especially at the metabolic level. In this study, we report a metabolomic profiling study on a classical model of KDS-Yangin rats induced by hydrocortisone injection to characterize the metabolic transformation using gas chromatography/time-of-flight mass spectrometry. WKY1, a polysaccharide extract fromAstragalus membranaceusandLycium barbarum, and WKY2, an aqueous ext

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Miao, Dongzhi, Xuebei Wu, Kui Zuo, et al. "Non-Targeted Metabolomics Analysis of Small Molecular Metabolites in Refrigerated Goose Breast Meat." Veterinary Sciences 11, no. 12 (2024): 637. https://doi.org/10.3390/vetsci11120637.

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Poultry represents a rich source of multiple nutrients. Refrigeration is commonly employed for poultry preservation, although extended storage duration can adversely affect the meat quality. Current research on this topic has focused on the analysis of biochemical indices in chilled goose meat, with limited information on changes in metabolites that influence the quality of the meat during storage. This study used non-targeted metabolomics and the random forest algorithm to investigate metabolite changes in goose meat over an extended storage period. The results showed a significant change in

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Lenchenko, Ekaterina M., Asiyat M. Abdullaeva, and Anton Al Pokrovsky. "INDICATION OF MICROBIAL BIOFILMS IN MONITORING THE BIOLOGICAL SAFETY OF FOOD RAW MATERIALS AND THE ENVIRONMENT." Problems of veterinary sanitation, hygiene and ecology 2, no. 50 (2024): 233–38. http://dx.doi.org/10.36871/vet.san.hyg.ecol.202402009.

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The data of the stages of development of biofilms of microorganisms of various microorganisms generalized, analyzed. The purpose of the study was to test and select methods for the preparation of preparations for the study of biofilms of isolates isolated during microbiological monitoring. Methodological approaches for visualization and differentiation of the component composition of mono and poly species biofilms have scientifically substantiated and experimentally confirmed. To differentiate the cells and components of the intercellular matrix, an aniline dye with metachromosic properties –

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Momin, Majed Abdul Basit, Anamika Aluri, G. Vamshi Krishna Reddy, and Rahul Dev Singh. "Primary Plasma Cell Leukaemia with Lambda Light Chain secretion and Chromosomal abnormalities presenting as hyperleukocytosis - A case report." Bangladesh Journal of Medical Science 22, no. 4 (2023): 932–36. http://dx.doi.org/10.3329/bjms.v22i4.67118.

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Primary plasma cell leukaemia (pPCL) is a rare and lethal form of plasma cell dyscrasia that can occur either de novo (primary) or as a leukemic transformation of refractory or relapsed multiple myeloma. We report a case of pPCL with lambda light chain disease and multiple chromosomal abnormalities in a 75-year-old female who presented with generalized weakness. Her peripheral blood smear showed hyperleukocytosis with 78% circulating plasma cells. Serum protein electrophoresis (SPE) does not reveal the M band and serum immunofixation (SI) light chain analysis in serum showed an elevated lambda

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Urzúa, Ulises, Arnaldo Marín, and Enrique A. Castellón. "Oxidative Stress, Parity History, and Remnant Follicles in the Aged Ovary: Insights on Ovarian Cancer Risk and Protection." Antioxidants 14, no. 7 (2025): 759. https://doi.org/10.3390/antiox14070759.

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Ovarian cancer (OC) is the most lethal gynecological cancer globally. Its incidence and mortality consistently rise after menopause. While parity reduces the risk of OC, nulliparity during a woman’s fertile years increases it. Although the association between reproductive history and OC risk is well-established, the long-term impact of pregnancy on the postmenopausal human ovary has received little to no attention. Parity apparently delays the natural decline of the ovarian reserve, but this association also remains unexplored to date. Based on data from cellular, biochemical, and histological

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DeClue, J. E., K. Zhang, P. Redford, W. C. Vass, and D. R. Lowy. "Suppression of src transformation by overexpression of full-length GTPase-activating protein (GAP) or of the GAP C terminus." Molecular and Cellular Biology 11, no. 5 (1991): 2819–25. http://dx.doi.org/10.1128/mcb.11.5.2819-2825.1991.

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Overexpression of the full-length GTPase-activating protein (GAP) has recently been shown to suppress c-ras transformation of NIH 3T3 cells but not v-ras transformation (36). Here, we show that focus formation induced by c-src was inhibited by approximately 80% when cotransfected with a plasmid encoding full-length GAP. In a similar assay, focus formation by the activated c-src (Tyr-527 to Phe) gene was inhibited by 33%. Cotransfection of the GAP C terminus coding sequences (which encode the GTPase-accelerating domain) with c-src or c-src527F inhibited transformation more efficiently than did

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DeClue, J. E., K. Zhang, P. Redford, W. C. Vass, and D. R. Lowy. "Suppression of src transformation by overexpression of full-length GTPase-activating protein (GAP) or of the GAP C terminus." Molecular and Cellular Biology 11, no. 5 (1991): 2819–25. http://dx.doi.org/10.1128/mcb.11.5.2819.

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Overexpression of the full-length GTPase-activating protein (GAP) has recently been shown to suppress c-ras transformation of NIH 3T3 cells but not v-ras transformation (36). Here, we show that focus formation induced by c-src was inhibited by approximately 80% when cotransfected with a plasmid encoding full-length GAP. In a similar assay, focus formation by the activated c-src (Tyr-527 to Phe) gene was inhibited by 33%. Cotransfection of the GAP C terminus coding sequences (which encode the GTPase-accelerating domain) with c-src or c-src527F inhibited transformation more efficiently than did

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Micchelli, S. T. L., D. Thomas, J. K. Boitnott, and M. Torbenson. "Hepatic giant cells in hepatitis C virus (HCV) mono-infection and HCV/HIV co-infection." Journal of Clinical Pathology 61, no. 9 (2008): 1058–61. http://dx.doi.org/10.1136/jcp.2008.058560.

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Background:The clinical and biological significance of syncytial giant cell change of hepatocytes in hepatitis C viral (HCV) infection is poorly understood.Aim:To investigate the clinical and histological correlates of giant cell transformation in the setting of HCV mono-infection and co-infection with HCV and HIV.Methods:The prevalence of hepatocyte giant cell transformation was determined and serological, biochemical and histological findings examined.Results:Among 856 liver biopsy specimens, 22 cases (2.6%) showed giant cell transformation, representing 18 individuals. The median serum ALT

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Kim, Taeyun, Hyunji Choi, and Sun Min Lee. "Parametric and non-parametric estimation of reference intervals for routine laboratory tests: an analysis of health check-up data for 260 889 young men in the South Korean military." BMJ Open 12, no. 7 (2022): e062617. http://dx.doi.org/10.1136/bmjopen-2022-062617.

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ObjectivesDetermination of reference intervals (RIs) using big data faces several obstacles due to heterogeneity in analysers, period and ethnicity. The present study aimed to establish the RIs for routine common blood count (CBC) and biochemistry laboratory tests in homogeneous, healthy, male Korean soldiers in their 20s using a large health check-up data set, comparing parametric and non-parametric estimation.DesignA multicentre, cross-sectional study.SettingSeven armed forces hospitals in South Korea.ParticipantsA total of 609 649 men underwent health examination when promoted to corporal b

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Peng, Yiwen, Wanyi Qin, and Min Qin. "Research on the correlation between campus big data and the mental health status of college students with a focus on biological implications." Molecular & Cellular Biomechanics 22, no. 1 (2025): 546. https://doi.org/10.62617/mcb546.

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This study aims to explore the potential association between multidimensional big data and the mental health status of college students, with a particular focus on biological implications. The goal is to utilize big data to achieve more accurate mental health services and timely psychological crisis interventions while addressing the shortcomings of traditional psychological assessments. We collect relevant big data from all undergraduate students at College J of a university. Through data preprocessing and quantitative transformation, students are identified as research subjects. Six represen

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Darenskaya, Marina A., Lubov I. Kolesnikova, and Sergey I. Kolesnikov. "Free radical reactions in socially significant infectious diseases: HIV infection, hepatitis, tuberculosis." Annals of the Russian academy of medical sciences 75, no. 3 (2020): 196–203. http://dx.doi.org/10.15690/vramn1328.

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The analysis of current literature data on the study of the features of the course of free-radical reactions, as well as the state of the antioxidant defense system at socially significant infectious diseases HIV infection, hepatitis, tuberculosis was carried out. The role of this kind of reaction in the genesis and progression of socially significant infections a long time has been studied. Foreign studies of recent years have been focused on the identification of specific markers of oxidative and carbonyl stress, which make it possible to identify the redox imbalance of the cell under condit

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Khatami, Fatemeh, and Seyed Mohammad Tavangar. "Multiple Endocrine Neoplasia Syndromes from Genetic and Epigenetic Perspectives." Biomarker Insights 13 (January 1, 2018): 117727191878512. http://dx.doi.org/10.1177/1177271918785129.

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Multiple endocrine neoplasia (MEN) syndromes are infrequent inherited disorders in which more than one endocrine glands develop noncancerous (benign) or cancerous (malignant) tumors or grow excessively without forming tumors. There are 3 famous and well-known forms of MEN syndromes (MEN 1, MEN 2A, and MEN 2B) and a newly documented one (MEN4). These syndromes are infrequent and occurred in all ages and both men and women. Usually, germ line mutations that can be resulted in neoplastic transformation of anterior pituitary, parathyroid glands, and pancreatic islets in addition to gastrointestina

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Keller-Przybylkowicz, Sylwia, Michal Oskiera, Xueqing Liu, et al. "Transcriptome Analysis of White- and Red-Fleshed Apple Fruits Uncovered Novel Genes Related to the Regulation of Anthocyanin Biosynthesis." International Journal of Molecular Sciences 25, no. 3 (2024): 1778. http://dx.doi.org/10.3390/ijms25031778.

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The red flesh coloration of apples is a result of a biochemical pathway involved in the biosynthesis of anthocyanins and anthocyanidins. Based on apple genome analysis, a high number of regulatory genes, mainly transcription factors such as MYB, which are components of regulatory complex MYB-bHLH-WD40, and several structural genes (PAL, 4CL, CHS, CHI, F3H, DFR, ANS, UFGT) involved in anthocyanin biosynthesis, have been identified. In this study, we investigated novel genes related to the red-flesh apple phenotype. These genes could be deemed molecular markers for the early selection of new app

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S., Vinod Kanna, and Jayabalan N. "Transformation and confirmation of GUS gene expression in Solanum melongena L. of PLR 1 cultivar." Annals of Plant Sciences 7, no. 4 (2018): 2185. http://dx.doi.org/10.21746/aps.2018.7.4.19.

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In the present study GUS gene transformation was carried out in eggplant using Agrobacterium strain with pBAL2 vector harboring gus gene and nptII as selection marker gene. The factors which are affecting (enhancing) the frequency of transient gus gene expression are different physical and biochemical variables has been carried out. It is observed that the 4 day precultured explants showed the minimum survival rate in the medium when compared with 2-day co cultivated medium. The explants which had undergone co-cultivation for 4 to 5 days showed GUS activity, the tissues were adversely affected

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Buckin, Vitaly. "High-resolution ultrasonic spectroscopy." Journal of Sensors and Sensor Systems 7, no. 1 (2018): 207–17. http://dx.doi.org/10.5194/jsss-7-207-2018.

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Abstract. High-resolution ultrasonic spectroscopy (HR-US) is an analytical technique for direct and non-destructive monitoring of molecular and micro-structural transformations in liquids and semi-solid materials. It is based on precision measurements of ultrasonic velocity and attenuation in analysed samples. The application areas of HR-US in research, product development, and quality and process control include analysis of conformational transitions of polymers, ligand binding, molecular self-assembly and aggregation, crystallisation, gelation, characterisation of phase transitions and phase

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Kumar, Sumit, Dushyant Kumar, Prashant Sharma, and Anita Punia. "Challenges and Opportunities in Bioprospecting for Sustainable Biofuel Production: Current Status and Future Perspectives." International Journal of Current Microbiology and Applied Sciences 11, no. 5 (2022): 230–54. http://dx.doi.org/10.20546/ijcmas.2022.1105.027.

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Increasing global energy demand and environmental concerns associated with petroleum have raised interest in biofuels to reduce dependency on crude oil and promote carbon-neutral energy generation. The information available suggests that biomass can become a sustainable and significant contributor to current energy demands if research and development in the field of thermochemical transformation for various biomass types are encouraged. The primary products of biofuel may be in a gas, liquid, or solid form. These products can be further converted by biochemical, physical, and thermochemical me

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Onelli, Elisabetta, Monica Scali, Marco Caccianiga, et al. "Microtubules play a role in trafficking prevacuolar compartments to vacuoles in tobacco pollen tubes." Open Biology 8, no. 10 (2018): 180078. http://dx.doi.org/10.1098/rsob.180078.

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Fine regulation of exocytosis and endocytosis plays a basic role in pollen tube growth. Excess plasma membrane secreted during pollen tube elongation is known to be retrieved by endocytosis and partially reused in secretory pathways through the Golgi apparatus. Dissection of endocytosis has enabled distinct degradation pathways to be identified in tobacco pollen tubes and has shown that microtubules influence the transport of plasma membrane internalized in the tip region to vacuoles. Here, we used different drugs affecting the polymerization state of microtubules together with SYP21, a marker

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