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Articles de revues sur le sujet « Bioengineered skin substitute »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Oualla-Bachiri, Wasima, Ana Fernández-González, María I. Quiñones-Vico, and Salvador Arias-Santiago. "From Grafts to Human Bioengineered Vascularized Skin Substitutes." International Journal of Molecular Sciences 21, no. 21 (2020): 8197. http://dx.doi.org/10.3390/ijms21218197.

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The skin plays an important role in the maintenance of the human’s body physiological homeostasis. It acts as a coverage that protects against infective microorganism or biomechanical impacts. Skin is also implied in thermal regulation and fluid balance. However, skin can suffer several damages that impede normal wound-healing responses and lead to chronic wounds. Since the use of autografts, allografts, and xenografts present source limitations and intense rejection associated problems, bioengineered artificial skin substitutes (BASS) have emerged as a promising solution to address these prob

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Tavakoli, Shima, and Agnes S. Klar. "Bioengineered Skin Substitutes: Advances and Future Trends." Applied Sciences 11, no. 4 (2021): 1493. http://dx.doi.org/10.3390/app11041493.

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As the largest organ in the human body, the skin has the function of maintaining balance and protecting from external factors such as bacteria, chemicals, and temperature. If the wound does not heal in time after skin damage, it may cause infection or life-threatening complications. In particular, medical treatment of large skin defects caused by burns or trauma remains challenging. Therefore, human bioengineered skin substitutes represent an alternative approach to treat such injuries. Based on the chemical composition and scaffold material, skin substitutes can be classified into acellular o

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Curran, Monique P., and Greg L. Plosker. "Bilayered Bioengineered Skin Substitute (Apligraf??*)." BioDrugs 16, no. 6 (2002): 439–55. http://dx.doi.org/10.2165/00063030-200216060-00005.

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Hirsch, Scott D., Jeremy M. Powers, and Jennifer L. Rhodes. "Neonatal Soft Tissue Reconstruction Using a Bioengineered Skin Substitute." Journal of Craniofacial Surgery 28, no. 2 (2017): 489–91. http://dx.doi.org/10.1097/scs.0000000000003346.

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Widgerow, Alan David. "Bioengineered Skin Substitute Considerations in the Diabetic Foot Ulcer." Annals of Plastic Surgery 73, no. 2 (2014): 239–44. http://dx.doi.org/10.1097/sap.0b013e31826eac22.

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Tobin, Micaela J., Audrey K. Mustoe, Sasha Nickman, et al. "Comparing Amniotic Membranes to Other Bioengineered Skin Substitutes in Wound Healing: A Propensity Score-Matched Analysis." Journal of Clinical Medicine 14, no. 12 (2025): 4272. https://doi.org/10.3390/jcm14124272.

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Background/Objectives: The amniotic membrane, which is widely available and inexpensive, has received recent attention for its potential applications in wound healing. This is the first study to use a large database to examine the efficacy of amniotic membrane grafting compared to other skin substitutes. Methods: The TriNetX electronic health database was queried in October 2024 for patients with burns or chronic skin ulcers. Patients were stratified by treatment with amniotic membrane grafts or another skin substitute. These patients were then 1:1 propensity score-matched based on age, demogr

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Haldar, Swati, Akriti Sharma, Sumeet Gupta, Samrat Chauhan, Partha Roy, and Debrupa Lahiri. "Bioengineered smart trilayer skin tissue substitute for efficient deep wound healing." Materials Science and Engineering: C 105 (December 2019): 110140. http://dx.doi.org/10.1016/j.msec.2019.110140.

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Nicoletti, Giovanni, Marco Mario Tresoldi, Alberto Malovini, Marco Visaggio, Angela Faga, and Silvia Scevola. "Versatile use of dermal substitutes: A retrospective survey of 127 consecutive cases." Indian Journal of Plastic Surgery 51, no. 01 (2018): 046–53. http://dx.doi.org/10.4103/ijps.ijps_217_17.

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ABSTRACT Background: Dermal substitutes are currently largely used for the treatment of huge skin loss in patients in critical general health conditions, for the treatment of severe burns and to promote the healing process in chronic wounds. Aims: The authors performed a retrospective assessment of their experience with bioengineered skin to possibly identify the most appropriate clinical indication and management for each substitute. Materials and Methods: The study involved 109 patients with 127 skin defects repaired with dermal substitutes over a 9 years period, from 2007 to 2016. Hyalomatr

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Mollapour Sisakht, Mahsa, Mohammad Ali Nilforoushzadeh, Javad Verdi, Hamid Reza Banafshe, Zahra Safaei Naraghi, and Seyed Abdolreza Mortazavi-Tabatabaei. "Fibrin-collagen hydrogel as a scaffold for dermoepidermal skin substitute, preparation and characterization." Journal of Contemporary Medical Sciences 5, no. 1 (2019): 8–13. http://dx.doi.org/10.22317/jcms.v5i1.519.

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Objective: Bioengineered skin substitutes were created to address wound healing problems. Skin substitutes contains live human cells seeded onto a matrix to provide cytokine, growth factor and other proteins from ECM required to decrease healing time. These products are classified based on their durability, the cells seeded on them and their originality. In this study, we aimed to investigate fibrin-collagen hydrogel as a new scaffold to design a bilayer temporary skin equivalent. Methods: Fibrin gel was prepared by crosslinking fibrinogen with thrombin and mixing it with collagen type 1

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Knox, Rebecca L., Allen R. Hunt, John C. Collins, Marie DeSmet, and Sara Barnes. "Platelet-Rich Plasma Combined With Skin Substitute for Chronic Wound Healing: A Case Report." Journal of ExtraCorporeal Technology 38, no. 3 (2006): 260–64. http://dx.doi.org/10.1051/ject/200638260.

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Contemporary management of chronic wounds focuses on improving natural healing and individualization of treatment. Incorporating multiple therapies has become increasingly common. Of interest are autologous growth factors, which are especially important in chronic wound healing and may contribute to tissue formation and epithelialization. Autologous platelet concentrate or platelet-rich plasma (PRP) is a concentration of at least five autologous growth factors and has been shown to accelerate wound healing and may have infection-fighting properties. Chronic wound healing is complicated by both

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DeCarbo, William T. "Special Segment: Soft Tissue Matrices—Bilayered Bioengineered Skin Substitute to Augment Wound Healing." Foot & Ankle Specialist 2, no. 6 (2009): 303–5. http://dx.doi.org/10.1177/1938640009353256.

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García-Valdivia, Marta, María I. Quiñones-Vico, Laura Ortega-Llamas, et al. "Cytotoxicity, Epidermal Barrier Function and Cytokine Evaluation after Antiseptic Treatment in Bioengineered Autologous Skin Substitute." Biomedicines 10, no. 6 (2022): 1453. http://dx.doi.org/10.3390/biomedicines10061453.

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Bioengineered autologous skin substitutes (BASS) technology is an emerging field for skin burn therapy. However, further studies on BASS characterization, viability against standard procedures for wound healing, and protocol optimization are necessary for the improvement of BASS technology for clinical use. The aim of this study is to evaluate the effect of common antiseptics for clinical use in BASS, focusing on cell viability, inflammatory cytokine pattern, and epithelium and skin barrier integrity, in order to establish the most adequate treatment for wound care after BASS grafting. Human k

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Schurr, Michael J., Kevin N. Foster, Mary A. Lokuta, et al. "Clinical Evaluation of NIKS-Based Bioengineered Skin Substitute Tissue in Complex Skin Defects: Phase I/IIa Clinical Trial Results." Advances in Wound Care 1, no. 2 (2012): 95–103. http://dx.doi.org/10.1089/wound.2011.0343.

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Jadlowiec, Caroline, Robert A. Brenes, Xin Li, et al. "Stem cell therapy for critical limb ischemia: what can we learn from cell therapy for chronic wounds?" Vascular 20, no. 5 (2012): 284–89. http://dx.doi.org/10.1258/vasc.2011.201206.

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Although much progress has been made regarding our knowledge of stem cells and their potential applications for therapeutic angiogenesis, there has been less success with the clinical application of this knowledge to patients with critical limb ischemia (CLI). Patients with CLI often have chronic wounds and newer cell-based therapies for chronic wounds show interesting parallels to stem cell therapy for CLI. Several human-derived wound care products and therapies, including human neonatal fibroblast-derived dermis (Dermagraft®), bilayered bioengineered skin substitute (Apligraf®), recombinant

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Dr., Falak Naaz*, Jaganadh Patro Dr., Fathima Najma, and Banala Keerthana. "COMPARATIVE EFFECTIVENESS OF STANDARD WOUND CARE, NEGATIVE PRESSURE WOUND THERAPY, AND BIOENGINEERED SKIN SUBSTITUTES IN DIABETIC FOOT ULCERS: A PROSPECTIVE OBSERVATIONAL STUDY." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 1116–24. https://doi.org/10.5281/zenodo.15365082.

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<strong>Background: </strong>Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes mellitus, associated with high morbidity, infection risk, and limb amputation. Standard wound care (SWC) often yields suboptimal outcomes in moderate-to-severe DFUs. This study aimed to compare the effectiveness of SWC alone versus its combination with negative pressure wound therapy (NPWT) or bio engineered skin substitutes (BSS) in promoting ulcer healing. <strong>Methods</strong>: A prospective observational study was conducted at a tertiary care center involving 150 patients with Wagner Gra

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Towler, Michael A., Elaine W. Rush, Melissa K. Richardson, and Calvin L. Williams. "Randomized, Prospective, Blinded-Enrollment, Head-To-Head Venous Leg Ulcer Healing Trial Comparing Living, Bioengineered Skin Graft Substitute (Apligraf) with Living, Cryopreserved, Human Skin Allograft (TheraSkin)." Clinics in Podiatric Medicine and Surgery 35, no. 3 (2018): 357–65. http://dx.doi.org/10.1016/j.cpm.2018.02.006.

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Urciuolo, Francesco, Costantino Casale, Giorgia Imparato, and Paolo A. Netti. "Bioengineered Skin Substitutes: The Role of Extracellular Matrix and Vascularization in the Healing of Deep Wounds." Journal of Clinical Medicine 8, no. 12 (2019): 2083. http://dx.doi.org/10.3390/jcm8122083.

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The formation of severe scars still represents the result of the closure process of extended and deep skin wounds. To address this issue, different bioengineered skin substitutes have been developed but a general consensus regarding their effectiveness has not been achieved yet. It will be shown that bioengineered skin substitutes, although representing a valid alternative to autografting, induce skin cells in repairing the wound rather than guiding a regeneration process. Repaired skin differs from regenerated skin, showing high contracture, loss of sensitivity, impaired pigmentation and abse

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Kiełt, Weronika, Julia Kozłowska, Gabriela Broniec, et al. "Composite skin substitutes, 3D skin bioprinting and the “BioMask” concept in regenerating skin defects - review." Journal of Education, Health and Sport 67 (September 14, 2024): 55096. http://dx.doi.org/10.12775/jehs.2024.67.55096.

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The treatment of skin trauma, especially facial skin trauma, is a major challenge due to its complex structure, the presence of appendages, color, texture, and the large area to be reconstructed in extensive trauma. “The gold standard” for treating trauma is autologous intermediate thickness skin grafting. An alternative solution is the usage of bioengineered skin substitutes. Tissue engineering is intended to provide patients with better treatment options and more effective pain reduction. Unique skin lesions are those related to the face. To fulfill the need to improve the results of facial

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Przekora, Agata. "A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?" Cells 9, no. 7 (2020): 1622. http://dx.doi.org/10.3390/cells9071622.

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Chronic wounds occur as a consequence of a prolonged inflammatory phase during the healing process, which precludes skin regeneration. Typical treatment for chronic wounds includes application of autografts, allografts collected from cadaver, and topical delivery of antioxidant, anti-inflammatory, and antibacterial agents. Nevertheless, the mentioned therapies are not sufficient for extensive or deep wounds. Moreover, application of allogeneic skin grafts carries high risk of rejection and treatment failure. Advanced therapies for chronic wounds involve application of bioengineered artificial

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Debels, Heidi, Moustapha Hamdi, Keren Abberton, and Wayne Morrison. "Dermal Matrices and Bioengineered Skin Substitutes." Plastic and Reconstructive Surgery Global Open 3, no. 1 (2015): e284. http://dx.doi.org/10.1097/gox.0000000000000219.

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Fortunate, Abaho Areeba. "Bioengineered Skin for Burn Victims: Advances and Challenges." Research Output Journal of Public Health and Medicine 4, no. 2 (2024): 6–11. http://dx.doi.org/10.59298/rojphm/2024/42611.

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Burn injuries impact millions worldwide, causing significant physical and psychological burdens due to scarring, limited function, and the risk of infection. Traditional skin grafting techniques have limitations in restoring full skin function and appearance, creating an urgent need for improved treatment methods. Bioengineered skin offers a promising alternative, utilizing tissue engineering, stem cell technology, and advanced scaffold materials to support skin regeneration and healing. This paper discusses the evolution of skin grafting, highlights current bioengineering approaches, includin

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Zelen, Charles M., Lisa Gould, Thomas E. Serena, Marissa J. Carter, Jennifer Keller, and William W. Li. "A prospective, randomised, controlled, multi‐centre comparative effectiveness study of healing using dehydrated human amnion/chorion membrane allograft, bioengineered skin substitute or standard of care for treatment of chronic lower extremity diabetic ulcers." International Wound Journal 12, no. 6 (2014): 724–32. http://dx.doi.org/10.1111/iwj.12395.

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Límová, Markéta. "Active Wound Coverings: Bioengineered Skin and Dermal Substitutes." Surgical Clinics of North America 90, no. 6 (2010): 1237–55. http://dx.doi.org/10.1016/j.suc.2010.08.004.

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Shapovalov, S. G., A. V. Kcheuso, T. E. Koshelev, and D. K. Savchenkov. "The possibilities of using bioengineered skin substitutes in combustiology (literature review)." Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations, no. 2 (August 3, 2022): 82–92. http://dx.doi.org/10.25016/2541-7487-2022-0-2-82-92.

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Relevance. Despite scientific and technological progress and improvement of treatment methods, providing assistance for thermal burns of the skin remains a complex multicomponent problem. Extensive deep burns are not capable of self-healing, and therefore, over the past century, autodermoplasty has become the standard method of treatment. However, the shortage of healthy tissues of the patient often does not allow the transplantation to be performed in full, which entails the need to search for options for replacing auto-tissues.Intention. To present modern possibilities and evaluate the probl

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Shoap, Seth, Sarah Cooper, and Wesley Rose. "Bioengineered skin substitutes in the treatment of burns and traumatic skin lesions." HAPS Educator 20, no. 3 (2016): 64–71. http://dx.doi.org/10.21692/haps.2016.014.

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Rampazzo, Silvia, Marco Ferrari, Maria Alessandra Sotgiu, et al. "Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal Substitutes." Life 14, no. 1 (2024): 121. http://dx.doi.org/10.3390/life14010121.

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Several dermal substitutes are available on the market, but there is no precise indication that helps surgeons choose the proper one. Few studies have tried to compare different xenogeneic bioengineered products, but no objective bio-parametric comparison has been made yet. Fifteen patients who underwent skin reconstruction with Integra® or Pelnac® were retrospectively evaluated. After at least 12 months of follow-up, an objective and quantitative assessment of several skin biophysical properties, such as color, texture, elasticity, hydration, glossiness and trans-epidermal water loss, were me

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Sudhan Muthu, R., Ravi Kumar Chittoria, and R. Shanmuga Priya. "Role of Diacoll – SB Dermal Regeneration Template in the Management of Burns." Archives of Medical Case Reports 7, no. 1 (2025): 1–3. https://doi.org/10.33696/casereports.7.033.

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The quality of skin wound healing can be improved by the application of collagen scaffolds as biological dermal substitutes. Diacoll-SB Dermal Regeneration Template (SB-DRT) is an advanced bioengineered collagen-based matrix that serves as a promising solution in the management of burn injuries. This study investigates the efficacy and role of Diacoll-SB in burn treatment by examining its impact on wound healing, scar formation, and the need for skin grafting. This study highlights Diacoll-SB as a valuable adjunct in the management of burns, contributing to more effective and aesthetic healing

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Primous, Nathaniel R., Peter T. Elvin, Kathleen V. Carter, et al. "Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review." Journal of Clinical Medicine 13, no. 5 (2024): 1221. http://dx.doi.org/10.3390/jcm13051221.

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Diabetic foot ulcers (DFUs) pose a significant threat to individuals with diabetes mellitus (DM), such as lower limb amputation and severe morbidity. Bioengineered skin substitutes (BSS) are alternatives to traditional interventions for treating DFUs, but their efficacy compared to standard wound care (SWC) or other treatment types, such as allografts, remains unknown. A scoping review of human studies was conducted to identify current approaches in the treatment of DFUs using BSS as compared with other treatment options. Systematic searches in PubMed, Cochrane Library, and Web of Science were

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Sanabria-de la Torre, Raquel, Ana Fernández-González, María I. Quiñones-Vico, Trinidad Montero-Vilchez, and Salvador Arias-Santiago. "Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis." Biomedicines 8, no. 11 (2020): 464. http://dx.doi.org/10.3390/biomedicines8110464.

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This review aims to be an update of Bioengineered Artificial Skin Substitutes (BASS) applications. At the first moment, they were created as an attempt to replace native skin grafts transplantation. Nowadays, these in vitro models have been increasing and widening their application areas, becoming important tools for research. This study is focus on the ability to design in vitro BASS which have been demonstrated to be appropriate to develop new products in the cosmetic and pharmacology industry. Allowing to go deeper into the skin disease research, and to analyze the effects provoked by envir

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Palmieri, Tina L. "Emerging Therapies for Full-Thickness Skin Regeneration." Journal of Burn Care & Research 44, Supplement_1 (2022): S65—S67. http://dx.doi.org/10.1093/jbcr/irac102.

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Abstract The classical treatment of extensive full-thickness skin loss due to trauma or burns has been the split-thickness skin graft. While split-thickness skin grafts close the wound, they leave patients with visible scars, dry skin, pruritis, pain, pigmentation alterations, and changes in sensation. The optimal replacement for full-thickness skin loss is replacement with intact full-thickness skin. New technologies combined with advances in the understanding of the mechanisms behind wound healing have led to the development of techniques and products that may eventually recapitulate the fun

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Lu, Gang, and Sha Huang. "Bioengineered skin substitutes: key elements and novel design for biomedical applications." International Wound Journal 10, no. 4 (2012): 365–71. http://dx.doi.org/10.1111/j.1742-481x.2012.01105.x.

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Augustine, Robin, Nandakumar Kalarikkal, and Sabu Thomas. "Advancement of wound care from grafts to bioengineered smart skin substitutes." Progress in Biomaterials 3, no. 2-4 (2014): 103–13. http://dx.doi.org/10.1007/s40204-014-0030-y.

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Pham, Clarabelle, John Greenwood, Heather Cleland, Peter Woodruff, and Guy Maddern. "Bioengineered skin substitutes for the management of burns: A systematic review." Burns 33, no. 8 (2007): 946–57. http://dx.doi.org/10.1016/j.burns.2007.03.020.

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AUGER, FRANÇOIS A., ROXANE POULIOT, NATHALIE TREMBLAY, et al. "MULTISTEP PRODUCTION OF BIOENGINEERED SKIN SUBSTITUTES: SEQUENTIAL MODULATION OF CULTURE CONDITIONS." In Vitro Cellular & Developmental Biology - Animal 36, no. 2 (2000): 96. http://dx.doi.org/10.1290/1071-2690(2000)036<0096:mpobss>2.0.co;2.

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AUGER, FRANÇOIS A., ROXANE POULIOT, NATHALIE TREMBLAY, et al. "MULTISTEP PRODUCTION OF BIOENGINEERED SKIN SUBSTITUTES: SEQUENTIAL MODULATION OF CULTURE CONDITIONS." In Vitro Cellular and Developmental Biology--Animal 36, no. 2 (2000): 96–103. http://dx.doi.org/10.1290/1071-2690(2000)036<0096:mpobss>2.3.co;2.

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Sadeghi, A. R., S. Nokhasteh, A. M. Molavi, M. Khorsand-Ghayeni, H. Naderi-Meshkin, and A. Mahdizadeh. "Surface modification of electrospun PLGA scaffold with collagen for bioengineered skin substitutes." Materials Science and Engineering: C 66 (September 2016): 130–37. http://dx.doi.org/10.1016/j.msec.2016.04.073.

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Nicoletti, Giovanni, Federica Brenta, Mariella Bleve, et al. "Long‐term in vivo assessment of bioengineered skin substitutes: a clinical study." Journal of Tissue Engineering and Regenerative Medicine 9, no. 4 (2014): 460–68. http://dx.doi.org/10.1002/term.1939.

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Lam, Everett Y., and Gregory L. Moneta. "Nonoperative Management of Venous Ulcers and the Emerging Role of Bioengineered Skin Substitutes." Perspectives in Vascular Surgery Volume 13, Number 3 (2000): 0069–80. http://dx.doi.org/10.1055/s-2000-9520.

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Lam, E. Y., and G. L. Moneta. "Nonoperative Management of Venous Ulcers and the Emerging Role of Bioengineered Skin Substitutes." Perspectives in Vascular Surgery and Endovascular Therapy 13, no. 2 (2000): 69–81. http://dx.doi.org/10.1177/153100350001300213.

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Fatima, Qandeel, Nakhshab Choudhry, and Mahmood S. Choudhery. "Umbilical Cord Tissue Derived Mesenchymal Stem Cells Can Differentiate into Skin Cells." Open Life Sciences 13, no. 1 (2018): 544–52. http://dx.doi.org/10.1515/biol-2018-0065.

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AbstractAutologous skin grafts are used to treat severe burn wounds, however, the availability of adequate donor sites makes this option less practical. Recently, stem cells have been used successfully in tissue engineering and in regenerative medicine. The current study aims to differentiate umbilical cord tissue derived mesenchymal stem cells (CT-MSCs) into skin cells (fibroblasts and keratinocytes) for use to treat severe burn wounds. After isolation, MSCs were characterized and their growth characteristics were determined. The cells were induced to differentiate into fibroblasts and kerati

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Barber, C., A. Watt, C. Pham, et al. "Influence of bioengineered skin substitutes on diabetic foot ulcer and venous leg ulcer outcomes." Journal of Wound Care 17, no. 12 (2008): 517–27. http://dx.doi.org/10.12968/jowc.2008.17.12.31766.

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PRZYBOROWSKI, MELISSA, and FRANCOIS BERTHIAUME. "NANOPARTICLES FOR SKIN WOUND HEALING." Nano LIFE 03, no. 03 (2013): 1342004. http://dx.doi.org/10.1142/s179398441342004x.

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Over the past two decades, there has been a surge in the development of nanoparticle technologies for therapeutic applications. In the area of skin wound healing, silver nanoparticles have been long used as topical antibacterials, but new types of multifunctional nanosystems that can provide more comprehensive therapeutic effects on wounds are being rolled out. The ability to provide a reservoir of bioactive molecules that can be released over time is a feature of many of these systems, which is critically important for nonhealing wounds, where there often is a persistent bacterial load and a

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Aleemardani, Mina, Michael Zivojin Trikić, Nicola Helen Green, and Frederik Claeyssens. "The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review." Bioengineering 8, no. 11 (2021): 148. http://dx.doi.org/10.3390/bioengineering8110148.

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There is a distinct boundary between the dermis and epidermis in the human skin called the basement membrane, a dense collagen network that creates undulations of the dermal–epidermal junction (DEJ). The DEJ plays multiple roles in skin homeostasis and function, namely, enhancing the adhesion and physical interlock of the layers, creating niches for epidermal stem cells, regulating the cellular microenvironment, and providing a physical boundary layer between fibroblasts and keratinocytes. However, the primary role of the DEJ has been determined as skin integrity; there are still aspects of it

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Naderi-Meshkin, Hojjat, Raheleh Amirkhah, Asieh Heirani-Tabasi, and Muhammad Irfan-maqsood. "Critical Issues in Successful Production of Skin Substitutes for Wound Healing." Journal of Genes and Cells 4 (February 26, 2018): 10. http://dx.doi.org/10.15562/gnc.63.

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Novel findings on fabrication techniques for bioactive materials, discovering further basic knowledge about wound healing process, and availability of stem cells as alternative candidate for differentiated cells have highly encouraged scientists for developing new bioengineered skin substitutes (BSS) that offer an effective remedy for a specific wound type. However, technical, clinical, legislative and economic reasons hamper wide-spread commercialization and clinical translation of BSS. Among the various types of strategies that target skin repair and regeneration, tissue engineering with ste

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Quiñones-Vico, María I., Ana Fernández-González, Elena Pérez-Castejón, Trinidad Montero-Vílchez, and Salvador Arias-Santiago. "Cytotoxicity and Epidermal Barrier Function Evaluation of Common Antiseptics for Clinical Use in an Artificial Autologous Skin Model." Journal of Clinical Medicine 10, no. 4 (2021): 642. http://dx.doi.org/10.3390/jcm10040642.

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Bioengineered artificial skin substitutes (BASS) are the main treatment used in addition to autografts when skin injuries involve a large body surface area. Antiseptic/antibiotic treatment is necessary to prevent infections in the BASS implant area. This study aims to evaluate the effect of antiseptics and antibiotics on cell viability, structural integrity, and epidermal barrier function in BASS based on hyaluronic acid during a 28 day follow-up period. Keratinocytes (KTs) and dermal fibroblasts (DFs) were isolated from skin samples and used to establish BASS. The following antibiotic/antisep

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Jeschke, Marc G., Ali-Reza Sadri, Cassandra Belo, and Saeid Amini-Nik. "A Surgical Device to Study the Efficacy of Bioengineered Skin Substitutes in Mice Wound Healing Models." Tissue Engineering Part C: Methods 23, no. 4 (2017): 237–42. http://dx.doi.org/10.1089/ten.tec.2016.0545.

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Hirt-Burri, Nathalie, Corinne Scaletta, Stefan Gerber, Dominique P. Pioletti, and Lee Ann Applegate. "Wound-healing Gene Family Expression Differences Between Fetal and Foreskin Cells Used for Bioengineered Skin Substitutes." Artificial Organs 32, no. 7 (2008): 509–18. http://dx.doi.org/10.1111/j.1525-1594.2008.00578.x.

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Mester, András, Diana Opincariu, Imre Benedek, and István Benedek. "Stem Cell Therapy in Wound Healing." Journal of Interdisciplinary Medicine 2, s4 (2017): 20–24. http://dx.doi.org/10.1515/jim-2017-0094.

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AbstractWound healing is a complex restorative process of the altered cutaneous tissue, which is impaired by numerous local and systemic factors, leading to chronic non-healing lesions with few efficient therapeutic options. Stem cells possess the capacity to differentiate into various types of cell lines. Furthermore, stem cells are able to secrete cytokines and growth factors, modulating inflammation and ultimately leading to angiogenesis, fibrogenesis, and epithelization. Because of their paracrine activity, these cells are able to attract other cell types to the base of the wound, improvin

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Osuna, Juan Angel Biguerias, Victoria Gallardo Chavez, and Jesus Antonio Galindo Castaneda. "Surgical management of burn injuries: current concepts and advancements in reconstructive strategies." International Surgery Journal 12, no. 6 (2025): 1044–48. https://doi.org/10.18203/2349-2902.isj20251550.

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Severe burn injuries pose complex clinical challenges requiring multidisciplinary management. Surgical intervention remains a cornerstone in the treatment of deep partial-thickness and full-thickness burns, aiming to achieve early wound closure, minimize infection risk, and restore function and aesthetics. This manuscript reviews the principles, timing, and techniques of surgical management of burn injuries, including early excision and grafting, reconstructive options, and recent advancements in surgical care aimed at improving patient outcomes. A comprehensive literature review was conducted

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Tan, Chew Teng, Kun Liang, Zong Heng Ngo, Christabel Thembela Dube, and Chin Yan Lim. "Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers." Biomedicines 8, no. 10 (2020): 441. http://dx.doi.org/10.3390/biomedicines8100441.

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Diabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15–25% of DM patients develop DFU at least once in their lifetime. The lack of effective wound dressings and targeted therapy for DFUs often results in prolonged hospitalization and amputations. As the incidence of DM is projected to rise, the demand for specialized DFU wound management will continue to increase. Hence, it is of great interest to improve and develop effective DFU-specific wound dressings and therapies. In

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