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Articles de revues sur le sujet « Blood proteins Physiology »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 29 janvier 2023

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1

Davies, Peter L., Choy L. Hew, and Garth L. Fletcher. "Fish antifreeze proteins: physiology and evolutionary biology." Canadian Journal of Zoology 66, no. 12 (December 1, 1988): 2611–17. http://dx.doi.org/10.1139/z88-385.

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Many marine teleosts have adapted to ice-laden seawater by evolving antifreeze proteins and glycoproteins. These proteins are synthesized in the liver for export to the blood where they circulate at levels of up to 20 mg/mL. There are at least four distinct antifreeze protein classes differing in carbohydrate content, amino acid composition, protein sequence, and secondary structure. In addition to antifreeze structural diversity, fish species differ considerably with respect to mechanisms controlling seasonal regulation of plasma antifreeze concentrations. Some species synthesize antifreeze p

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Jia, Ruizhe, Jingyun Li, Can Rui, Hui Ji, Hongjuan Ding, Yuanqing Lu, Wei De, and Lizhou Sun. "Comparative Proteomic Profile of the Human Umbilical Cord Blood Exosomes between Normal and Preeclampsia Pregnancies with High-Resolution Mass Spectrometry." Cellular Physiology and Biochemistry 36, no. 6 (2015): 2299–306. http://dx.doi.org/10.1159/000430193.

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Background/Aims: Exosomes are extracellular vesicles that are involved in several biological processes. The roles of proteins from human umbilical cord blood exosomes in the pathogenesis of preeclampsia remains poorly understood. Methods: In this study, we used high-resolution LC-MS/MS technologies to construct a comparative proteomic profiling of human umbilical cord blood exosomes between normal and preeclamptic pregnancies. Results: A total of 221 proteins were detected in human umbilical cord blood exosomes, with 14 upregulated and 15 downregulated proteins were definitively identified bet

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Croxatto, HR. "How Many Peptidic Hormones Can Derive From Blood Plasma Proteins?" Physiology 5, no. 5 (October 1, 1990): 201–4. http://dx.doi.org/10.1152/physiologyonline.1990.5.5.201.

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Peptides having structures identical or related to some already known hormones have been obtained using pepsin as a hydrolytic agent acting at acid pH upon plasma substrates. The data suggest the existence of systems similar to renin-angiotensin for the generation of active peptides other than angiotensin or kinins.

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Ohno, H., K. Yamashita, R. Doi, K. Yamamura, T. Kondo, and N. Taniguchi. "Exercise-induced changes in blood zinc and related proteins in humans." Journal of Applied Physiology 58, no. 5 (May 1, 1985): 1453–58. http://dx.doi.org/10.1152/jappl.1985.58.5.1453.

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Effects of cycle ergometer exercise (approximately 75% maximum ventilatory O2 consumption for 30 min) on the concentrations of zinc and related proteins in erythrocytes and/or plasma were studied on 11 sedentary male students. Lower concentrations of total zinc and of zinc derived from carbonic anhydrase I type (CA-I) in erythrocytes were observed immediately after exercise, but they disappeared after 30 min of rest. The change in total zinc concentration in erythrocytes correlated well with that in CA-I concentration immediately after exercise, as well as after rest. The concentration of carb

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Teahan, Carmel G., Hugh A. McKenzie, and Mervyn Griffiths. "Some monotreme milk “whey” and blood proteins." Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 99, no. 1 (January 1991): 99–118. http://dx.doi.org/10.1016/0305-0491(91)90014-5.

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Richardson, Samantha J., Julie A. Monk, Caroline A. Shepherdley, Lars O. E. Ebbesson, Frank Sin, Deborah M. Power, Peter B. Frappell, Josef Köhrle, and Marilyn B. Renfree. "Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 5 (May 2005): R1264—R1272. http://dx.doi.org/10.1152/ajpregu.00793.2004.

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Thyroid hormones are essential for vertebrate development. There is a characteristic rise in thyroid hormone levels in blood during critical periods of thyroid hormone-regulated development. Thyroid hormones are lipophilic compounds, which readily partition from an aqueous environment into a lipid environment. Thyroid hormone distributor proteins are required to ensure adequate distribution of thyroid hormones, throughout the aqueous environment of the blood, and to counteract the avid partitioning of thyroid hormones into the lipid environment of cell membranes. In human blood, these proteins

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Synelnyk, T. B., O. O. Kravchenko, O. S. Kostiuk, O. M. Savchuk, S. A. Sukhodolia, and L. I. Ostapchenko. "DISTRIBUTION OF SERINE PROTEASES IN BLOOD PLASMA AND PANCREAS IN CHRONIC PANCREATITIS AND ONCOPATHOLOGY." Fiziolohichnyĭ zhurnal 68, no. 6 (December 8, 2022): 31–43. http://dx.doi.org/10.15407/fz68.06.031.

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The aim of our study was to evaluate the trypsin-like serine proteases (TLPs) distribution between systemic circulation and pancreatic tissue and to investigate the peculiarities of their involvement in the extracellular matrix components degradation in patients with pancreatic pathologies with electrophoretic analysis methods using. Тhe Khmelnitsky Regional Clinical Hospital patients aged 28-89 were selected for this study: 20 people with chronic pancreatitis (group CP); 20 people with pancreatic cancer (group PC); 20 conditionally healthy persons (control). Blood plasma samples and pancreati

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Lampe, L., K. Wienhold, G. Meyer, F. Baisch, H. Maass, W. Hollmann, and R. Rost. "Effects of simulated microgravity (HDT) on blood fluidity." Journal of Applied Physiology 73, no. 4 (October 1, 1992): 1366–69. http://dx.doi.org/10.1152/jappl.1992.73.4.1366.

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Exposures to microgravity and head-down tilt (HDT) produce similar changes in body fluid. This causes an increase in hematocrit that significantly affects hemorheological values. Lack of physical stimulation under bed rest conditions and the relative immobility of the crew during spaceflight also affects the blood fluidity. A group of six healthy male subjects participated as volunteers, and blood samples were collected 10 days before, on day 2 and day 9, and 2 days after the HDT phase. Blood rheology was quantified by plasma viscometry, red cell aggregability, and red cell deformability. A re

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Martino, Tami A., Nazneen Tata, Georg A. Bjarnason, Marty Straume, and Michael J. Sole. "Diurnal protein expression in blood revealed by high throughput mass spectrometry proteomics and implications for translational medicine and body time of day." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293, no. 3 (September 2007): R1430—R1437. http://dx.doi.org/10.1152/ajpregu.00183.2007.

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Molecular gene cycling is useful for determining body time of day (BTOD) with important applications in personalized medicine, including cardiovascular disease and cancer, our leading causes of death. However, it impractically requires repetitive invasive tissue sampling that is obviously not applicable for humans. Here we characterize diurnal protein cycling in blood using high-throughput proteomics; blood proteins are easily accessible, minimally invasive, and can importantly serve as surrogates for what is happening elsewhere in the body in health and disease. As proof of the concept, we us

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van de Graaf, Stan F. J., Joost G. J. Hoenderop, and René J. M. Bindels. "Regulation of TRPV5 and TRPV6 by associated proteins." American Journal of Physiology-Renal Physiology 290, no. 6 (June 2006): F1295—F1302. http://dx.doi.org/10.1152/ajprenal.00443.2005.

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The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulati

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Rossing, T. H., N. Maffeo, and V. Fencl. "Acid-base effects of altering plasma protein concentration in human blood in vitro." Journal of Applied Physiology 61, no. 6 (December 1, 1986): 2260–65. http://dx.doi.org/10.1152/jappl.1986.61.6.2260.

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We altered the concentration of plasma proteins in human blood in vitro by adding solutions with [Na+], [K+], and [Cl-] resembling those in normal blood plasma, either protein-free or with a high concentration of human albumin. After equilibrating the samples with a gas containing 5% CO2-12% O2–83% N2 at 37 degrees C, we measured pH, PCO2, and PO2; in separated plasma, we determined the concentrations of total plasma proteins and albumin and of the completely dissociated electrolytes (strong cations Na+, K+, Mg2+ and anions Cl-, citrate3-). With PCO2 nearly constant (mean = 35.5 Torr; coeffici

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Persu, Alexandre. "G proteins: fine tuning of blood pressure regulation." Journal of Hypertension 23, no. 8 (August 2005): 1465–67. http://dx.doi.org/10.1097/01.hjh.0000174610.72145.76.

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Hom, Sharon, Melissa A. Fleegal, Richard D. Egleton, Christopher R. Campos, Brian T. Hawkins, and Thomas P. Davis. "Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 292, no. 5 (May 2007): R1881—R1892. http://dx.doi.org/10.1152/ajpregu.00761.2005.

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Hypertension is involved in the exacerbation of stroke. It is unclear how blood-brain barrier (BBB) tight-junction (TJ) and ion transporter proteins critical for maintaining brain homeostasis contribute to cerebral infarction during hypertension development. In the present study, we investigated cerebral infarct volume following permanent 4-h middle cerebral artery occlusion (MCAO) and characterized the expression of BBB TJ and ion transporter proteins in brain microvessels of spontaneously hypertensive rats (SHR) compared with age-matched Wistar-Kyoto (WKY) rats at 5 wk (prehypertension), 10

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Rubinsky, B., M. Mattioli, A. Arav, B. Barboni, and G. L. Fletcher. "Inhibition of Ca2+ and K+ currents by "antifreeze" proteins." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 262, no. 3 (March 1, 1992): R542—R545. http://dx.doi.org/10.1152/ajpregu.1992.262.3.r542.

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For the last two decades, the research on fish “antifreeze” proteins has focused exclusively on their ability to depress noncolligatively blood plasma freezing points, presumably by binding to ice crystals. We report evidence that antifreeze polypeptides from the winter flounder (Pseudopleuronectes americanus) have another special property, the ability to block ion channels. In experiments with porcine granulosa cells we show, using the patch-clamp technique in the whole cell configuration, that these proteins suppress effectively calcium and potassium currents. The results of dose-response st

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Pastushkova, L. Kh, A. G. Goncharova, G. Yu Vasilyeva, S. K. Tagirova, D. N. Kashirina, O. V. Sayk, J. Rittweger, and I. M. Larina. "Search for Blood Proteome Proteins Involved in the Regulation of Bone Remodeling in Astronauts." Human Physiology 45, no. 5 (September 2019): 536–42. http://dx.doi.org/10.1134/s0362119719050128.

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Kucherenko, Yuliya V., and Ingolf Bernhardt. "Natural Antioxidants Improve Red Blood Cell “Survival” in Non-Leukoreduced Blood Samples." Cellular Physiology and Biochemistry 35, no. 5 (2015): 2055–68. http://dx.doi.org/10.1159/000374012.

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Background: Blood collected in an anticoagulant can be kept refrigerated in an unmodified state within 5 - 6 weeks. Oxidative damage is considered to be a one of the major factors contributing to the development of storage lesions. Lipid and membrane proteins oxidation results in changes in cation gradients that affect the cell survival. Aim: In the present study we used the natural antioxidants and ion channels blockers (L-carnosine, spermine, phloretin and their mixtures) to prolong “survival” of red blood cells (RBCs), measured as the lack of PS exposure and cell hemolysis, in the Alsever's

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Klyuyev, D. A., L. E. Muravlyova, and V. B. Molotov-Luchanskiy. "Oxidized proteins in blood cells of patients with chronic kidney disease." Free Radical Biology and Medicine 65 (September 2013): S35. http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.043.

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Muravlyova, Larissa, Vilen Molotov-Luchanskiy, Ryszhan Bakirova, Dmitriy Klyuvev, Ludmila Demidchik, Dinara Omertayeva, Valentina Lee, and Irina Beinikova. "Oxidazed proteins in blood of patients with nephropathies of various origins." Free Radical Biology and Medicine 120 (May 2018): S53. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.174.

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Koos, Robert D. "Minireview: Putting Physiology Back into Estrogens' Mechanism of Action." Endocrinology 152, no. 12 (September 27, 2011): 4481–88. http://dx.doi.org/10.1210/en.2011-1449.

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After decades of research, the mechanism by which estrogens stimulate the proliferation of epithelial cells in the endometrium and mammary gland, and in the carcinomas that arise in those tissues, is still not understood. Cells do not proliferate in response to 17β-estradiol (E2) alone, and although it is widely recognized that growth factors play a role in E2's proliferative effect, exactly how they are involved is unclear. It has long been known that the proliferation of endometrial epithelial cells is preceded by dramatic increases in blood flow and microvascular permeability, filling the s

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Ratych, I. B. "Petro Lahodyuk — Doctor of Biological Sciences, Professor, Academician of the National Academy of Agrarian Sciences of Ukraine, Honourable Man of Science and Technology of Ukraine (1924–1994)." Animal Biology 22, no. 3 (September 2020): 8–10. http://dx.doi.org/10.15407/animbiol22.03.008.

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Petro Lahodyuk is the Doctor of Biological Sciences, professor, Academician of NAAS, Honourable Man of Science and Technology of Ukraine. Academician Lahodyuk was a leading researcher of animal lactation physiology. He contributed greatly into research on fraction composition and antigene properties of soluble proteins in mammary gland of open heifers, heifers and lactating cows, open and pregnant cows, compared their immune and chemical properties with milk and blood serum proteins, researched amino acidic and peptoid content of albumins in mammary gland tissues and blood serum of open heifer

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Ouali, Radouane, Larissa Rezende Vieira, Didier Salmon, and Sabrina Bousbata. "Early Post-Prandial Regulation of Protein Expression in the Midgut of Chagas Disease Vector Rhodnius prolixus Highlights New Potential Targets for Vector Control Strategy." Microorganisms 9, no. 4 (April 11, 2021): 804. http://dx.doi.org/10.3390/microorganisms9040804.

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Chagas disease is a vector-borne parasitic disease caused by the flagellated protozoan Trypanosoma cruzi and transmitted to humans by a large group of bloodsucking triatomine bugs. Triatomine insects, such as Rhodnius prolixus, ingest a huge amount of blood in a single meal. Their midgut represents an important interface for triatomine–trypanosome interactions. Furthermore, the development of parasites and their vectorial transmission are closely linked to the blood feeding and digestion; thus, an understanding of their physiology is essential for the development of new strategies to control t

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Ohanyan, Vahagn, Sean M. Raph, Marc M. Dwenger, Xuemei Hu, Thomas Pucci, Gregory Mack, Joseph B. Moore, William M. Chilian, Aruni Bhatnagar та Matthew A. Nystoriak. "Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins". Circulation Research 128, № 6 (19 березня 2021): 738–51. http://dx.doi.org/10.1161/circresaha.120.317715.

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Rationale: Voltage-gated potassium (Kv) channels in vascular smooth muscle are essential for coupling myocardial blood flow (MBF) with the metabolic demand of the heart. These channels consist of a transmembrane pore domain that associates with auxiliary Kvβ (voltage-gated potassium channel β)1 and Kvβ2 proteins, which differentially regulate Kv function in excitable cells. Nonetheless, the physiological role of Kvβ proteins in regulating vascular tone and metabolic hyperemia in the heart remains unknown. Objective: To test the hypothesis that Kvβ proteins confer oxygen sensitivity to vascular

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Santamaria, Salvatore, and Rens de Groot. "ADAMTS proteases in cardiovascular physiology and disease." Open Biology 10, no. 12 (December 2020): 200333. http://dx.doi.org/10.1098/rsob.200333.

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The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood. The best characterized cardiovascular role is that of ADAMTS-13 in blood. Moderately low ADAMTS-13 levels increase the risk of ischeamic stroke and very low levels (less than 10%) can cause thrombotic thrombocytopenic purpura (TTP). Recombinant ADAMTS-13 is currently in clinical trials for treatment of TTP. Recently, new cardiovascular roles for ADAMTS proteases have been discovere

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Manns, J. G., and P. J. Lewing. "Protein production by sheep embryos during the period of maternal recognition of pregnancy." Canadian Journal of Physiology and Pharmacology 64, no. 9 (September 1, 1986): 1223–28. http://dx.doi.org/10.1139/y86-207.

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An embryo must be present in the uterus 12–13 days after estrus to prevent regression of the ovine corpus luteum. The present experiments were designed to determine if embryo-specific secretory proteins could be detected in the maternal blood at the time of maternal recognition of pregnancy. In two experiments, 92 embryos were flushed from 47 ewes at 14–15 days after estrus. Embryos were incubated in vitro for 24 h and the proteins in the media were harvested. Antisera to proteins in both flushing and incubation medium were produced in rabbits. In experiment 1, crude fractions were used for an

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Kobayashi, T., K. Nitta, R. Takahashi, K. Kurashima, B. Robertson, and Y. Suzuki. "Activity of pulmonary surfactant after blocking the associated proteins SP-A and SP-B." Journal of Applied Physiology 71, no. 2 (August 1, 1991): 530–36. http://dx.doi.org/10.1152/jappl.1991.71.2.530.

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This study investigated the role of sympathetic withdrawal on blood flow responses in cutaneous arteriovenous anastomoses (AVAs) and capillaries to direct and indirect heat stress. This was achieved by clamping sympathetic activity (SC) to the tail of anesthetized rats so that constrictor tone remained invariant during exposure of either the animal's tail (direct heating) or body (indirect heating) to a 35 degrees C environment. Flow through the AVAs in the tail was evaluated by laser-Doppler flowmetry (LDF), while capillary flow was investigated by videodensitometry measurements of blood cell

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Saari, Jack T. "Copper deficiency and cardiovascular disease: role of peroxidation, glycation, and nitration." Canadian Journal of Physiology and Pharmacology 78, no. 10 (October 1, 2000): 848–55. http://dx.doi.org/10.1139/y00-054.

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Dietary copper deficiency causes a variety of cardiovascular deficits. Systemic effects include high blood pressure, enhancement of inflammation, anemia, reduced blood clotting, and possibly arteriosclerosis. Effects on specific organs or tissues include weakened structural integrity of the heart and blood vessels, impairment of energy use by the heart, reduced ability of the heart to contract, altered ability of blood vessels to control their diameter and grow, and altered structure and function of circulating blood cells. In some instances, the cause of a defect can be directly attributed to

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Rentsch, Rikke Louise, Rasmus Damsgaard, Carsten Lundby, and Carsten Juel. "Effects of darbepoetin injections on erythrocyte membrane transport protein expressions in humans." Journal of Applied Physiology 101, no. 1 (July 2006): 164–68. http://dx.doi.org/10.1152/japplphysiol.01376.2005.

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The present study investigated the effects of injected darbepoetin [novel erythropoietin stimulating protein (NESP)] on the density of three erythrocyte membrane transport proteins: the lactate-H+ cotransporter (monocarboxylate transporter 1), the chloride/bicarbonate exchanger 1 (anion exchanger 1), and the water channel aquaporin 1. Thirteen subjects were injected with NESP once a week for 4 wk. Blood samples were obtained before, during, and after the injection period, and the erythrocyte transport proteins were determined by Western blotting. The NESP injections induced a transient increas

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Kwaan, Hau C. "Role of plasma proteins in whole blood viscosity: A brief clinical review." Clinical Hemorheology and Microcirculation 44, no. 3 (2010): 167–76. http://dx.doi.org/10.3233/ch-2010-1271.

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Seth, Henrik, Erik Sandblom, and Michael Axelsson. "Nutrient-induced gastrointestinal hyperemia and specific dynamic action in rainbow trout (Oncorhynchus mykiss)—importance of proteins and lipids." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 296, no. 2 (February 2009): R345—R352. http://dx.doi.org/10.1152/ajpregu.90571.2008.

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Mechanical gastric distension induces a dorsal aortic pressor response in rainbow trout ( Oncorhynchus mykiss) with no change in gastrointestinal blood flow. To elucidate what role chemical stimuli from the digested food has on the postprandial cardiovascular response, a new method was developed to investigate the contribution of individual nutrient components. Three predigested experimental diets were injected directly into the proximal intestine of rainbow trout and cardiac output (CO), gut blood flow (Qcma), heart rate (HR), and stroke volume (SV) were recorded. Specific dynamic action (SDA

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NYGREN, H., J. H. ELAM, and M. STENBERG. "Adsorption of coagulation proteins and adhesion and activation of platelets at the blood-solid interface. An experimental study of human whole blood." Acta Physiologica Scandinavica 133, no. 4 (August 1988): 573–77. http://dx.doi.org/10.1111/j.1748-1716.1988.tb08443.x.

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Anderson, G. Harvey. "Proteins and amino acids: effects on the sympathetic nervous system and blood pressure regulation." Canadian Journal of Physiology and Pharmacology 64, no. 6 (June 1, 1986): 863–70. http://dx.doi.org/10.1139/y86-149.

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Many functions of the brain and the sympathetic adrenal system are influenced by those amino acids that exert precursor control over neurotransmitter synthesis. One of the functions affected is regulation of blood pressure. Therefore, the purpose of this review is to describe how food proteins and amino acids affect the synthesis of neurotransmitters and their regulation of blood pressure.

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Ehrhart, I. C., L. L. McCloud, S. E. Orfanos, J. D. Catravas, and W. F. Hofman. "Effect of high blood flow on pulmonary vascular permeability to protein." Journal of Applied Physiology 76, no. 6 (June 1, 1994): 2342–47. http://dx.doi.org/10.1152/jappl.1994.76.6.2342.

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The elevated cardiac output associated with exercise increases lung lymph flow and may increase extravascular lung water. However, it is not known if extremely elevated cardiac output alters pulmonary vascular permeability. The hematocrit-protein method was used to determine the solvent drag reflection coefficient, an index of vascular permeability to proteins, in the isolated blood-perfused canine lung lobe. Microvascular pressure was obtained by double vascular occlusion. Lobes filtered fluid during perfusion at normal flow, 0.451 +/- 0.005 l/min (LF; n = 8), or high flow, 2.319 +/- 0.080 l/

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Valério, Patricia, Simeon Agathopoulos, A. J. Calado, M. Fatima Leite, and Alfredo Goes. "Attachment of Blood Cells onto ZrO₂ and SiO₂-Containing Glass." Key Engineering Materials 284-286 (April 2005): 671–74. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.671.

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Samples of zirconia and a bioinert SiO2-containing glass with different surface roughness were immersed into human whole blood for different settling times to investigate the adhesion and attachment of blood cells onto these materials. The cell/material interface was directly observed by scanning electron microscopy (SEM). The results indicate that the blood cells preserved their physiology and attaching capability regardless the type of material, surface roughness, and settling time. The SEM images strongly indicate the normal function of adhesion proteins.

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Clarkson, Priscilla M., Eric P. Hoffman, Edward Zambraski, Heather Gordish-Dressman, Amy Kearns, Monica Hubal, Brennan Harmon, and Joseph M. Devaney. "ACTN3 and MLCK genotype associations with exertional muscle damage." Journal of Applied Physiology 99, no. 2 (August 2005): 564–69. http://dx.doi.org/10.1152/japplphysiol.00130.2005.

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Strenuous exercise results in damage to skeletal muscle that is manifested in delayed muscle pain, prolonged strength loss, and increases in muscle proteins in the blood, especially creatine kinase (CK) and myoglobin (Mb). Some individuals experience profound changes in these variables in response to standard laboratory exercise or recreational activities. We proposed that variations in genes coding for two myofibrillar proteins [α-actinin 3 (ACTN3) and myosin light chain kinase (MLCK)] may explain the large variability in the response to muscle-damaging exercise. We hypothesized that subjects

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Larina, I. M., A. G. Brzhzovsky, A. M. Nosovsky, M. I. Indeykina, A. S. Kononikhin, E. N. Nikolaev, and O. I. Orlov. "Oxidative Posttranslational Modifications of Blood Plasma Proteins of Cosmonauts after a Long-Term Flight: Part II." Human Physiology 47, no. 4 (July 2021): 438–47. http://dx.doi.org/10.1134/s0362119721040095.

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Reiber, Hansotto. "Cerebrospinal fluid - physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases." Multiple Sclerosis Journal 4, no. 3 (June 1998): 99–107. http://dx.doi.org/10.1177/135245859800400302.

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The state of the art in routine CSF analysis is reviewed with particular reference to multiple sclerosis regarding: (1) The physiology and pathophysiology of blood-CSF barrier function and dysfunction with the CSF flow rate as main modulator of blood- and brain-derived protein concentrations in CSF; (2) The neuroimmunological aspects regarding (a) patterns of disease-related immunoglobulin class response (IgG, lgA, IgM) in actual Reiber graphs with reference to specific parameters and optional tests, and (b) the oligoclonal, polyspecific antibody synthesis in brain; (3) Particular marker prote

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Sarkar, Oli, Yuan Li та Madhu B. Anand-Srivastava. "Resveratrol prevents the development of high blood pressure in spontaneously hypertensive rats through the inhibition of enhanced expression of Giα proteins". Canadian Journal of Physiology and Pharmacology 97, № 9 (вересень 2019): 872–79. http://dx.doi.org/10.1139/cjpp-2019-0040.

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Resveratrol (RV), a polyphenolic component of red wine, has been shown to attenuate high blood pressure (BP) in spontaneously hypertensive rats (SHRs). We previously found that the enhanced expression of Giα proteins plays a role in the pathogenesis of hypertension in SHRs. In the present study, we investigated whether this RV-induced decrease in BP in SHRs can be attributed to the ability of RV to inhibit the enhanced expression of Giα proteins and the upstream signaling molecules implicated in the overexpression of Giα proteins. Administration of RV (50 mg/kg per day) to prehypertensive 2-we

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Wolf, Matthew B., and Edward C. DeLand. "A mathematical model of blood-interstitial acid-base balance: application to dilution acidosis and acid-base status." Journal of Applied Physiology 110, no. 4 (April 2011): 988–1002. http://dx.doi.org/10.1152/japplphysiol.00514.2010.

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We developed mathematical models that predict equilibrium distribution of water and electrolytes (proteins and simple ions), metabolites, and other species between plasma and erythrocyte fluids (blood) and interstitial fluid. The models use physicochemical principles of electroneutrality in a fluid compartment and osmotic equilibrium between compartments and transmembrane Donnan relationships for mobile species. Across the erythrocyte membrane, the significant mobile species Cl−is assumed to reach electrochemical equilibrium, whereas Na+and K+distributions are away from equilibrium because of

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Maron, M. B., and C. F. Pilati. "Effect of papaverine on pulmonary vascular permeability to proteins." Journal of Applied Physiology 65, no. 3 (September 1, 1988): 1367–71. http://dx.doi.org/10.1152/jappl.1988.65.3.1367.

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Previous studies have suggested that papaverine, a drug commonly used in studies of transvascular fluid and solute exchange to eliminate confounding effects of changes in vascular tone, may itself increase vascular permeability. In this study, we determined the ability of papaverine to alter pulmonary vascular protein permeability by measuring the osmotic reflection coefficient (sigma) for total proteins in a canine isolated perfused left lower lung lobe (LLL) preparation. The reflection coefficient, determined by the hematocrit-protein double-indicator technique, for control LLL's was 0.83 +/

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Muravlyova, L. E., V. B. Molotov-Luchanskiy, D. A. Kluev, and E. A. Kolesnikova. "Oxidized proteins in blood of patients with very severe chronic obstructive pulmonary disease." Free Radical Biology and Medicine 65 (September 2013): S39—S40. http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.055.

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Brooks, Tracy A., Brian T. Hawkins, Jason D. Huber, Richard D. Egleton, and Thomas P. Davis. "Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 2 (August 2005): H738—H743. http://dx.doi.org/10.1152/ajpheart.01288.2004.

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The blood-brain barrier (BBB) maintains brain homeostasis by limiting entry of substances to the central nervous system through interaction of transmembrane and intracellular proteins that make up endothelial cell tight junctions (TJs). Recently it was shown that the BBB can be modulated by disease pathologies including inflammatory pain. This study examined the effects of chronic inflammatory pain on the functional and molecular integrity of the BBB. Inflammatory pain was induced by injection of complete Freund's adjuvant (CFA) into the right plantar hindpaw in female Sprague-Dawley rats unde

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Bentley, PJ. "The Crystalline Lens of the Eye: An Organismal Microcosm." Physiology 1, no. 6 (December 1, 1986): 195–99. http://dx.doi.org/10.1152/physiologyonline.1986.1.6.195.

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The lens of the eye is transparent due to several special characteristics, including the lack of a blood supply, a tight geometric arrangement of its cells, and high concentrations of special proteins called crystallins, which in solution provide a transparent medium. Opacities of the lens (cataracts), which are especially prevalent in old age, appear to result from damage to lens proteins and cell membranes. Causes of such damage include radiation, sunlight toxic chemicals and drugs, and, of special current interest, naturally occurring oxidants.

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Liu, Jun-hua, Ting-ting Xu, Yu-jie Liu, Wei-yun Zhu, and Sheng-yong Mao. "A high-grain diet causes massive disruption of ruminal epithelial tight junctions in goats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 305, no. 3 (August 1, 2013): R232—R241. http://dx.doi.org/10.1152/ajpregu.00068.2013.

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Alterations in rumen epithelial tight junctions (TJs) at the tissue and molecular levels during high-grain (HG) diet feeding are unknown. Here, 10 male goats were randomly assigned to either a hay diet (0% grain; n = 5) or HG diet group (65% grain; n = 5) to characterize the changes in ruminal epithelial structure and TJ protein expression and localization using scanning and transmission electron microscopy, quantitative real-time PCR, Western blot analysis, and immunofluorescence. After 7 wk of feeding, ruminal free LPS in HG group increased significantly ( P < 0.001) compared with the hay

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Lu, Yan, David E. Stec, Ruisheng Liu, Michael Ryan та Heather A. Drummond. "βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole". American Journal of Physiology-Renal Physiology 322, № 5 (1 травня 2022): F498—F511. http://dx.doi.org/10.1152/ajprenal.00003.2022.

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Transmission of systemic blood pressure to delicate renal microvessels is a primary determinant of vascular injury in chronic kidney disease progression to end-stage renal disease. Here, we identified two degenerin family members, with an evolutionary link to mechanosensing, that interact biochemically and functionally to regulate systemic blood pressure and renal injury. Thus, degenerin proteins may serve as a target for the development of therapies to prevent or delay renal disease progression.

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Gliński, Z., J. Jarosz, and A. Wernicki. "Serological characterization of soluble proteins in greater wax moth larval blood." Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 84, no. 1 (January 1986): 131–35. http://dx.doi.org/10.1016/0305-0491(86)90282-8.

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Yang, Y., M. Zhou, and H. Liu. "Luteolin, an aryl hydrocarbon receptor antagonist, alleviates diabetic retinopathy by regulating the NLRP/NOX4 signalling pathway: Experimental and molecular docking study." Physiology International 108, no. 2 (July 9, 2021): 172–84. http://dx.doi.org/10.1556/2060.2021.00148.

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AbstractObjectiveThe present report evaluates the protective effects of luteolin against diabetic retinopathy (DR).Materials and methodsDiabetes was induced in rats by i.p. administration of 60 mg/kg of streptozotocin (STZ), followed by treatment with luteolin for 4 weeks. The effects of luteolin were determined based on the blood glucose and cytokine levels, and parameters of oxidative stress in retinal tissue of DR rats. The diameter of retinal vessels was estimated by fundus photography. A Western blot assay was used to determine the expression of apoptotic proteins and Nod-like receptor 3

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Larina, I. M., A. G. Brzhzovsky, A. M. Nosovsky, A. S. Kononikhin, and O. I. Orlov. "Post-Translational Oxidation Modifications of Blood Plasma Proteins of Cosmonauts after a Long-term Flight: Part I." Human Physiology 46, no. 5 (September 2020): 531–39. http://dx.doi.org/10.1134/s0362119720050072.

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Sayer, J. A., and S. H. S. Pearce. "Diagnosis and Clinical Biochemistry of Inherited Tubulopathies." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 38, no. 5 (September 2001): 459–70. http://dx.doi.org/10.1177/000456320103800503.

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Epithelial ion channels and transporter proteins have physiologically important roles throughout the length of the nephron. Discovering the molecular identities of tubular epithelial cell proteins and their functional roles has increased understanding of both renal physiology and tubular diseases. Defects in tubular handling of solutes may present with nephrocalcinosis or nephrolithiasis, rickets, acid-base, electrolyte or blood pressure disturbances. Biochemical analysis of both serum and urine, together with clinical history and examination, remain fundamental for their diagnosis, whilst und

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Lux, Samuel E. "Anatomy of the red cell membrane skeleton: unanswered questions." Blood 127, no. 2 (January 14, 2016): 187–99. http://dx.doi.org/10.1182/blood-2014-12-512772.

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Abstract The red cell membrane skeleton is a pseudohexagonal meshwork of spectrin, actin, protein 4.1R, ankyrin, and actin-associated proteins that laminates the inner membrane surface and attaches to the overlying lipid bilayer via band 3–containing multiprotein complexes at the ankyrin- and actin-binding ends of spectrin. The membrane skeleton strengthens the lipid bilayer and endows the membrane with the durability and flexibility to survive in the circulation. In the 36 years since the first primitive model of the red cell skeleton was proposed, many additional proteins have been discovere

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Cho, Sung Hoon, Shreevrat Goenka, Tiina Henttinen, Prathyusha Gudapati, Arja Reinikainen, Christine M. Eischen, Riitta Lahesmaa, and Mark Boothby. "PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells." Blood 113, no. 11 (March 12, 2009): 2416–25. http://dx.doi.org/10.1182/blood-2008-03-144121.

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Poly(ADP-ribos)ylation is one of the longest-known but most enigmatic posttranslational modifications transducing specific signals. The enzyme responsible for the majority of poly(ADP-ribose) polymerization in cells, PARP-1, promotes DNA repair but also mediates a caspase-independent form of apoptosis in response to stressors such as irradiation. However, the biologic function of most other PARPs is not known. Macro-PARPs constitute one branch of the large family of PARP-like proteins also designated as B aggressive lymphoma proteins (BAL1, 2a/2b, 3, or PARP-9, PARP-14, and PARP-15). To elucid

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