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Littérature scientifique sur le sujet « BRG »

Auteur : Grafiati

Publié le 1 avril 2023

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Articles de revues sur le sujet "BRG"

Kiefer, Márta, et Adam Török. « BRG ». Eastern European Economics 36, n^o 1 (janvier 1998) : 9–18. http://dx.doi.org/10.1080/00128775.1998.11648647.

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Pini, Núbia Inocencya Pavesi, Luciana Manzotti De-Marchi, Bruno Frazão Gribel, Adilson Luiz Ramos, Laurindo Zanco Furquim et Renata Corrêa Pascotto. « Analysis of width/height ratio and gingival zenith in patients with bilateral agenesis of maxillary lateral incisor ». Dental Press Journal of Orthodontics 17, n^o 5 (octobre 2012) : 87–93. http://dx.doi.org/10.1590/s2176-94512012000500013.

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OBJECTIVE: The purpose of this study was to evaluate the width/length ratio and the gingival zenith (GZ), by means of dental casts and digital caliper, in patients with missing maxillary lateral incisors after treatment. METHODS: The sample was composed of 52 subjects divided into 3 groups: BRG (n = 18), patients with bilateral agenesis treated with tooth re-contouring; BIG (n = 10) patients with agenesis treated with implants and CG (n = 24), control group. The data were analyzed using Shapiro-Wilk, Spearman correlation, Wilcoxon, Kruskal-Wallis, t test and ANOVA tests (p < 0.05). RESULTS: For the width/length ratio of the lateral incisors, BIG presented the lowest mean values (0.72 right and left), when compared with other groups. However, comparison between groups presented statistically significant differences for the right lateral incisor (BIG x CG) and for the canine (BRG x CG). GZ data evaluation showed the greatest difference for BRG (0.5 right and 0.48 left). BIG (0.95 right and 0.98 left) and CG (0.98 right and 0.8 left) presented more similar values, nevertheless, without statistical difference (p > 0.05). GZ data for the right and left sides of the smile were not considered statistically different. CONCLUSION: Although no statistical difference was found in the comparison between the groups, analysis of the descriptive values showed that group BIG showed the greatest difference in values with regard to width/length ratio. Regarding gingival zenith, BRG showed the greatest difference.

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Jani, Anant, Mimi Wan, Jianmin Zhang, Kairong Cui, Jie Wu, Paula Preston-Hurlburt, Rohini Khatri, Keji Zhao et Tian Chi. « A novel genetic strategy reveals unexpected roles of the Swi–Snf–like chromatin-remodeling BAF complex in thymocyte development ». Journal of Experimental Medicine 205, n^o 12 (27 octobre 2008) : 2813–25. http://dx.doi.org/10.1084/jem.20080938.

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We have developed a general strategy for creating littermates bearing either a tissue-specific point mutation or deletion in any target gene, and used the method to dissect the roles of Brg, the ATPase subunit of the chromatin-remodeling Brg-associated factor (BAF) complex, in early thymocyte development. We found that a point mutation that inactivates the Brg ATPase recapitulates multiple defects previously described for Brg deletion (Chi, T.H., M. Wan, P.P. Lee, K. Akashi, D. Metzger, P. Chambon, C.B. Wilson, and G.R. Crabtree. 2003. Immunity. 19:169–182). However, the point mutant helps reveal unexpected roles of Brg in CD25 repression and CD4 activation. Surprisingly, CD4 activation occurs independently of the Brg ATPase and is perhaps mediated by physical interactions between Brg and the CD4 locus. Our study thus suggests that the BAF complex harbors novel activities that can be necessary and even sufficient for stimulating transcription from an endogenous chromatin template in the absence of Brg-dependent remodeling of that template. We conclude that conditional point mutants, rarely used in mammalian genetics, can help uncover important gene functions undetectable or overlooked in deletion mutants.

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Ma, Zhendong, Mi Jung Chang, Reesha Shah, Jill Adamski, Xueyan Zhao et Etty N. Benveniste. « Brg-1 Is Required for Maximal Transcription of the Human Matrix Metalloproteinase-2 Gene ». Journal of Biological Chemistry 279, n^o 44 (17 août 2004) : 46326–34. http://dx.doi.org/10.1074/jbc.m405438200.

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases whose aberrant expression are correlated with tumor invasion and angiogenesis. The transcription factors Sp1, Sp3, and AP-2 are required for constitutive expression ofMMP-2in tumor cells; however, the regulatory mechanisms ofMMP-2expression are not well understood. We investigated the involvement of Brg-1, the ATPase subunit of the SWI/SNF complex, in human MMP-2 gene transcription. Reconstitution of Brg-1 enhancesMMP-2transcription in Brg-1-deficient SW-13 cells. Chromatin immunoprecipitation assay demonstrates that Brg-1 is required for recruitment of Sp1, AP-2, and polymerase II to the MMP-2 promoter, whereas the binding of Sp3 to the MMP-2 promoter is decreased upon Brg-1 reconstitution. Furthermore, Sp1 interacts with Brg-1in vivo. Restriction enzyme accessibility assays indicate that accessibility of the MMP-2 promoter region is not changed in the absence or presence of Brg-1. These results illustrate the connection between the SWI/SNF complex and optimal expression ofMMP-2and highlight the critical function of Brg-1 in regulating the recruitment of Sp1, Sp3, AP-2, and polymerase II to the MMP-2 promoter.

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DiRenzo, James, Yongfeng Shang, Michael Phelan, Säid Sif, Molly Myers, Robert Kingston et Myles Brown. « BRG-1 Is Recruited to Estrogen-Responsive Promoters and Cooperates with Factors Involved in Histone Acetylation ». Molecular and Cellular Biology 20, n^o 20 (15 octobre 2000) : 7541–49. http://dx.doi.org/10.1128/mcb.20.20.7541-7549.2000.

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ABSTRACT Several factors that mediate activation by nuclear receptors also modify the chemical and structural composition of chromatin. Prominent in this diverse group is the steroid receptor coactivator 1 (SRC-1) family, which interact with agonist-bound nuclear receptors, thereby coupling them to multifunctional transcriptional coregulators such as CREB-binding protein (CBP), p300, and PCAF, all of which have potent histone acetyltransferase activity. Additionally factors including the Brahma-related gene 1 (BRG-1) that are involved in the structural remodeling of chromatin also mediate hormone-dependent transcriptional activation by nuclear receptors. Here, we provide evidence that these two distinct mechanisms of coactivation may operate in a collaborative manner. We demonstrate that transcriptional activation by the estrogen receptor (ER) requires functional BRG-1 and that the coactivation of estrogen signaling by either SRC-1 or CBP is BRG-1 dependent. We find that in response to estrogen, ER recruits BRG-1, thereby targeting BRG-1 to the promoters of estrogen-responsive genes in a manner that occurs simultaneous to histone acetylation. Finally, we demonstrate that BRG-1-mediated coactivation of ER signaling is regulated by the state of histone acetylation within a cell. Inhibition of histone deacetylation by trichostatin A dramatically increases BRG-1-mediated coactivation of ER signaling, and this increase is reversed by overexpression of histone deacetylase 1. These studies support a critical role for BRG-1 in ER action in which estrogen stimulates an ER–BRG-1 association coupling BRG-1 to regions of chromatin at the sites of estrogen-responsive promoters and promotes the activity of other recruited factors that alter the acetylation state of chromatin.

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Mudhasani, Rajini, et Joseph D. Fontes. « The Class II Transactivator Requires brahma-Related Gene 1 To Activate Transcription of Major Histocompatibility Complex Class II Genes ». Molecular and Cellular Biology 22, n^o 14 (15 juillet 2002) : 5019–26. http://dx.doi.org/10.1128/mcb.22.14.5019-5026.2002.

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ABSTRACT The class II transactivator (CIITA) is the key regulator of major histocompatibility complex (MHC) class II gene transcription. We demonstrate here that CIITA requires the ATPase subunit of an hSWI/SNF complex, brahma-related gene 1 (BRG-1), to activate transcription. When introduced into a cell line lacking BRG-1, CIITA was unable to activate cellular MHC class II genes. Reexpression of the wild-type but not an ATP-binding-deficient BRG-1 protein in this cell line restored the ability of CIITA to transactivate transcription of MHC class II genes. Interestingly, when the activity of CIITA was assayed in the BRG-1-deficient cell line by using a plasmid-based reporter assay, BRG-1 was not required for transcriptional activation, suggesting that the chromatin structure on the plasmid is such that BRG-1 is not necessary. Coimmunoprecipitation experiments were performed to determine if BRG-1 and CIITA proteins associate with each other in cells. We found that the two proteins coimmunoprecipitate and that amino acids 1 to 140 of CIITA are sufficient for binding. Taken together, these data suggest that BRG-1 and, very likely, an hSWI/SNF complex are required for transcription of MHC class II genes. The complex is likely recruited to MHC class II promoters, at least in part, by interaction with CIITA.

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Camidge, D. Ross, Hye Ryun Kim, Myung-Ju Ahn, James Chih-Hsin Yang, Ji-Youn Han, Maximilian Hochmair, Ki Hyeong Lee et al. « Association of depth of target lesion response to brigatinib with outcomes in patients with ALK inhibitor-naive ALK+ NSCLC in ALTA-1L. » Journal of Clinical Oncology 40, n^o 16_suppl (1 juin 2022) : 9072. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.9072.

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9072 Background: In patients (pts) with crizotinib (CRZ)-refractory advanced ALK+ NSCLC in the phase 2 ALTA trial (NCT02094573), the depth of target lesion response to brigatinib (BRG) correlated with PFS and OS. Here, we examine the association of maximum decrease in target lesions with PFS and OS in ALTA-1L (NCT02737501), a randomized phase 3 trial of BRG vs CRZ in pts with ALK inhibitor-naive advanced ALK+ NSCLC. Methods: Pts were randomized 1:1 to receive BRG 180 mg qd (7-day lead-in at 90 mg; n=137) or CRZ 250 mg bid (n=138). Pts with target lesion assessment by blinded independent review committee (BIRC) were grouped based on greatest decrease from baseline per RECIST v1.1: none–50%, 51%–75%, and 76%–100% shrinkage. Outcomes in the ≤50% target lesion shrinkage group served as the comparator for outcomes in the 51%–75% and 76%–100% groups. Results: At study end (last pt contact: Jan 29, 2021), 124/137 pts in the BRG arm and 125/138 pts in the CRZ arm had ≥1 evaluable target lesion assessment; female (BRG/CRZ), 51%/59%; median age, 57.5/60.0 years. Median follow-up was 40.8/15.7 months. In BRG/CRZ arms, 76%-100% shrinkage was observed in 56%/34% of pts, 51%-75% shrinkage in 27%/30%, and ≤50% shrinkage in 16%/35%, respectively. BRG was associated with significantly more pts with target lesion shrinkage >75% vs CRZ ( P=0.0005), and a Cochran-Armitage trend analysis demonstrated significantly deeper response across all shrinkage groups for BRG compared with CRZ ( P<0.0001). A majority of pts in the BRG arm experienced 76%–100% target lesion shrinkage in all subgroups analyzed. Pts treated with BRG or CRZ with target lesion shrinkage >50% had lower risk of a PFS event (BRG HR [95% CI]: 51%–75% shrinkage, 0.58 [0.29–1.18]; 76%–100%, 0.23 [0.12–0.46]; CRZ: 51%–75% shrinkage, 0.68 [0.41–1.12]; 76%–100%, 0.26 [0.15–0.45]) or an OS event (BRG: 51%–75% shrinkage, 0.39 [0.17–0.89]; 76%–100%, 0.15 [0.07–0.35]; CRZ: 51%–75% shrinkage, 0.43 [0.21–0.85]; 76%–100%, 0.23 [0.10–0.50]) than pts with ≤50% shrinkage. Longer median time to PFS and OS and higher 4-year estimated OS rates were associated with depth of response in both arms (Table). Conclusions: In this exploratory post hoc analysis, BRG demonstrated significantly deeper target lesion response vs CRZ. Pts with >75% shrinkage had significantly reduced risk of a PFS or OS event vs pts with ≤50% target lesion shrinkage. Clinical trial information: NCT02737501. [Table: see text]

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Roncella, S., G. Cutrona, A. Favre, M. Ulivi, F. Fais, A. Signorini, CE Grossi, N. Chiorazzi et M. Ferrarini. « Apoptosis of Burkitt's lymphoma cells induced by specific interaction of surface IgM with a self-antigen : implications for lymphomagenesis in acquired immunodeficiency syndrome ». Blood 88, n^o 2 (15 juillet 1996) : 599–608. http://dx.doi.org/10.1182/blood.v88.2.599.bloodjournal882599.

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In a previous study, we described a cell line (BRG-P) derived from a woman with Burkitt's lymphoma (BL) and acquired immunodeficiency syndrome that shared the same characteristic cytogenetic abnormalities as the patient's malignant cells. This cell line contained subclones that displayed an isotype switch from IgM to IgA1 and an accumulation of point mutations in the Vh region genes. Because these two features suggested an antigen-driven process, we began a search for the antigen responsible for the stimulation of the malignant B cells. Specifically, we hypothesized that because the patient's tumor had presented as a lymphomatous infiltration of the breast, the malignant B cells were recruited to this site because of the reactivity of their surface lg with breast tissue. A hybridoma (BRG-H) was obtained by fusing BRG-M cells (an IgM producing subclone of the BRG-P cell) with an appropriate cellular partner. The monoclonal antibody (BRG MoAb) produced by this hybridoma reacted strongly with two of five breast cancer cell lines and stained normal and malignant ductal epithelial cells on breast tissue sections. The antigen recognized by the BRG MoAb consisted of a single, minimally glycosylated polypeptide chain of 45 kD (p45). The BRG MoAb failed to react with a panel of human cell lines from different tissues, except for one cell line from a uterine cervical carcinoma. No reactivity was detected for a panel of exogenous antigens from various pathogens, including human immunodeficiency virus and self- antigens frequently recognized by polyspecific antibodies. Experiments were performed to investigate the functional consequences of the interaction of surface IgM with its specific ligand. Coculture of BRG-M cells with p45+, but not with p45-, breast cells caused apoptosis of BRG-M cells. The specificity of the interaction was shown by the observation that apoptosis was prevented by pretreatment of BRG-M cells with a monovalent F(ab′) fragment of rabbit IgG antibody to human mu chains. Moreover, only BRG-M cells, but not other BL cells, underwent apoptosis after exposure to p45+ breast cells. The interaction between the CD40 molecule expressed by BRG-M cells and its specific ligand (CD40L) prevented p45-induced cell apoptosis. Because this interaction mimics that occurring in vivo between T and B cells during immune responses, our data suggest that various events contributed to the emergence of the BL, in this particular patient, including antigenic stimulation possibly assisted by T-cell help.

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Ahn, Myung-Ju, HyeRyun Kim, James Chih-Hsin Yang, Ji-Youn Han, Jong Seok Lee, Maximilian J. Hochmair, Jacky Yu-Chung Li et al. « Brigatinib (BRG) versus crizotinib (CRZ) in Asian versus non-Asian patients (pts) in the phase III ALTA-1L trial. » Journal of Clinical Oncology 37, n^o 15_suppl (20 mai 2019) : 9026. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.9026.

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9026 Background: We report an analysis of BRG vs CRZ in Asian vs non-Asian pts with ALK inhibitor–naive, ALK+ NSCLC from ALTA-1L (NCT02737501). Methods: Pts were randomized 1:1 to BRG 180 mg QD (7-day lead-in at 90 mg) or CRZ 250 mg BID. Primary endpoint: blinded independent review committee (BIRC)-assessed PFS (RECIST v1.1). Secondary efficacy endpoints: BIRC-assessed ORR, intracranial (i) ORR, and iPFS. Results: 275 pts were randomized; 108 Asian (BRG/CRZ, n = 59/49), 167 non-Asian (n = 78/89); median age: Asian, 55/56 y; non-Asian, 60/60 y. 32/24% of Asians vs 22/28% of non-Asians received prior chemotherapy for advanced disease; 36/33% vs 24/28% had baseline CNS metastases. As of 19 Feb 2018, median follow-up was 10.1/10.0 mo (BRG/CRZ) in Asians vs 11.0/9.0 mo in non-Asians, with 12 vs 20 PFS events in Asians and 24 vs 43 in non-Asians. In Asians, median BIRC-assessed PFS (mo) was not reached (NR; 95% CI 11.2–NR) with BRG vs 11.1 (9.2–NR) with CRZ (HR 0.41 [95% CI 0.20–0.86]; log-rank P= 0.0261); in non-Asians, BRG PFS was NR (NR) vs 9.4 (7.3–NR) with CRZ (HR 0.54 [0.33–0.90]; log-rank P= 0.0132) (Table). AE profile of each drug was similar in Asians vs non-Asians. Most common any-grade AEs (≥25%) in Asians in BRG arm: diarrhea; elevated blood CPK, ALT, and AST. Discontinuation due to AE (BRG/CRZ): 8.5/6.3% in Asian pts; 14.3/10.1% in non-Asian pts. Conclusions: BRG showed comparable improvement in PFS vs CRZ both in Asians and non-Asians in ALK inhibitor–naive ALK+ NSCLC. Clinical trial information: NCT02737501. [Table: see text]

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Shi, Xiaolan, Zijiao Chen, Yi Yang et Su Yan. « Bile Reflux Gastritis : Insights into Pathogenesis, Relevant Factors, Carcinomatous Risk, Diagnosis, and Management ». Gastroenterology Research and Practice 2022 (12 septembre 2022) : 1–7. http://dx.doi.org/10.1155/2022/2642551.

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Bile reflux gastritis (BRG), a kind of gastrointestinal disorder in clinical practice, is characterized by regurgitation and inflammation. However, lack of guidelines leads to simple cognition and even ignorance of this disease for clinicians. Primarily, making the pathogenesis of BRG clear contributes to a correct and general understanding of this disease for physicians. Next, although recently there has been an increasing awareness among researchers in terms of the relevant factors for BRG, further studies involving large samples are still required to certify the relationship between them explicitly. Besides, researches have established that BRG is closely associated with the development of precancerous lesions and gastric cancer. Till now, there is still no golden standard for diagnosis of BRG. Nevertheless, advances in techniques, especially extensive applications of endoscopy and chemical analysis of reflux contents, have improved our ability to identify the occurrence of this disease as well as distinguishing physiological reflux from pathological reflux. Finally, it is fortunate for patients that more and more importance has been attached to the treatment of BRG. From lifestyle modification to drug therapy to surgery, all of them with the view of realizing symptomatic relief are employed for patients with BRG. In this review, we briefly evaluate this disorder based on the best available evidence, offering an overview of its complicated pathogenesis, diverse relevant factors, potential carcinomatous risk, modern diagnostic investigations, and effective therapeutic plans.

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Thèses sur le sujet "BRG"

Bock, Vanessa Leonie. « The Role of Brm, Brg-1, Snail 1 and Snail 2 in the Progression of Non-Melanoma Skin Cancer ». Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/4091.

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Non-melanoma skin cancer (NMSC) is the most common human cancer worldwide. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) make up almost all NMSC. SCC usually arises from actinic keratosis (AK) as a result of exposure to sunlight. SCC and AK provide a useful clinical model to investigate changes involved in the progression of NMSC. This project examines the expression of Brm, Brg-1, Snail 1 and Snail 2 in the progression of NMSC. Brm and Brg-1 are subunits of the SWI/SNF chromatin-remodelling complex which is involved in regulating the access of cell machinery to DNA by altering the structure of chromatin. It has been suggested that loss of this function is involved in carcinogenesis as the cell is unable to access to DNA normally in order to repair mutations or activate apoptosis. The loss of Brm or Brg-1 has been described in several human cancers. Snail 1 and Snail 2 are zinc-finger transcription factors that are known for their role in epithelial to mesenchymal transition (EMT), a process vital to embryological development. Increased expression of these factors leads to a loss of cell-cell adhesion and a migratory phenotype and has been described in some human cancers. In this project, double-label immunohistochemistry was used to determine the relative expression of these proteins in human SCC, BCC, AK and normal skin. The expression of Snail was unable to be determined due to poor specificity of the antibodies used. The expression of both Brm and Brg-1 proteins was found to be dramatically and consistently decreased in SCC and BCC when compared to normal skin and AK. This loss of Brm and Brg-1 occured as the tumour progressed from benign AK to malignant SCC. This finding suggests that the loss of either Brm or Brg-1 constitutes a key step in carcinogenesis. The results of this study identify Brm and Brg-1 as putative tumour suppressors involved in the progression of non-melanoma skin cancer from benign to malignant.

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Bock, Vanessa Leonie. « The Role of Brm, Brg-1, Snail 1 and Snail 2 in the Progression of Non-Melanoma Skin Cancer ». University of Sydney, 2008. http://hdl.handle.net/2123/4091.

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Master of Medicine
Non-melanoma skin cancer (NMSC) is the most common human cancer worldwide. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) make up almost all NMSC. SCC usually arises from actinic keratosis (AK) as a result of exposure to sunlight. SCC and AK provide a useful clinical model to investigate changes involved in the progression of NMSC. This project examines the expression of Brm, Brg-1, Snail 1 and Snail 2 in the progression of NMSC. Brm and Brg-1 are subunits of the SWI/SNF chromatin-remodelling complex which is involved in regulating the access of cell machinery to DNA by altering the structure of chromatin. It has been suggested that loss of this function is involved in carcinogenesis as the cell is unable to access to DNA normally in order to repair mutations or activate apoptosis. The loss of Brm or Brg-1 has been described in several human cancers. Snail 1 and Snail 2 are zinc-finger transcription factors that are known for their role in epithelial to mesenchymal transition (EMT), a process vital to embryological development. Increased expression of these factors leads to a loss of cell-cell adhesion and a migratory phenotype and has been described in some human cancers. In this project, double-label immunohistochemistry was used to determine the relative expression of these proteins in human SCC, BCC, AK and normal skin. The expression of Snail was unable to be determined due to poor specificity of the antibodies used. The expression of both Brm and Brg-1 proteins was found to be dramatically and consistently decreased in SCC and BCC when compared to normal skin and AK. This loss of Brm and Brg-1 occured as the tumour progressed from benign AK to malignant SCC. This finding suggests that the loss of either Brm or Brg-1 constitutes a key step in carcinogenesis. The results of this study identify Brm and Brg-1 as putative tumour suppressors involved in the progression of non-melanoma skin cancer from benign to malignant.

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STROBECK, MATTHEW WILLIAM. « THE ROLE OF CHROMATIN REMODELING IN RB-MEDIATED CELL CYCLE ARREST ». University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1014728057.

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Olson, Ted. « The 1927 Bristol Sessions : The Big Bang, or the Big Brag of Country Music ? » Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/1208.

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Pilgren, Ludvig. « Borg, berg och bygd. : Selaötraktens fornborgar under den mellersta järnåldern ». Thesis, Stockholms universitet, Institutionen för arkeologi och antikens kultur, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102046.

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This paper deals with hill-forts located on and directly south of Selaön, in the center of Mälardalen, Södermanland, dated to the late roman period and the migration period. Of special interest is differences and similarities between the forts when it comes to their morphology and the hills where they were built. Furthermore, their landscape has been examined and I have tried to put the hill-forts in relation to any iron age settlements.

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Tosato, João Miguel Toledo. « Segregação no transporte de fertilizantes comercializados em embalagens "BiG Bag" ». UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2006. http://tede2.uepg.br/jspui/handle/prefix/2234.

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Made available in DSpace on 2017-07-25T19:29:57Z (GMT). No. of bitstreams: 1 joaomigueltosato.pdf: 1509704 bytes, checksum: 7feec9d7e4ee880e76e5c9e750d8c419 (MD5) Previous issue date: 2006-09-19
The majority of mineral fertilizers used in Brazil are sold in the form of granules mixture in order to provide, lower storage and transportation costs, lower probability of hardening, easier handling and also to simplify its use. Despite the advantages mentioned, such mixtures, which might present two or three primary macronutrients, secondary macronutrients and micronutrients, must have these nutrients uniformly distributed, so that the distribution in the field is homogeneous. However, in this kind of mixture some problems of heterogeneity might occur due to the segregation of granules, which might result in segregation of nutrients that will produce irregular application. The segregation is worrying concerning the application of the fertilizer as well as the sampling by the inspector, once it might generate analysis result that does not match the product real composition. The volume of fertilizers in a Big Bag makes it impossible for the inspector to homogenize the product prior to sampling, as required by law, in the case of smaller packets, thus requiring its own sampling methodology. Therefore, with the aim of evaluating the segregation of fertilizers and determining a sampling methodology for the Big Bag packaging, a study was developed, based on two formulas 02-30-10 and 12-15-15 distributed into four Big Bags each. Three sampling at three different times were carried out. The first was performed soon after packaging, the second, after the Big Bags had been transported on a truck for 407 km and the last after 696 km, both on dirty road and on asphalt. A conic tip double tube steering steel probe, for the sampling of five distinct horizontal levels, five vertical, one in the middle and one in each corner of the packet as well as one diagonal, which went through granulometric and chemical analysis individually. One compound sample was produced by pushing the probe vertically at three distinct points, and later on adding to the four packets portions for analysis. The results of granulometric and chemical analysis , at several points of sampling carried out in the vertical, horizontal e diagonal as well as the compound, after packaging and transportation of the Big Bags, in both formulas studied, show that if a grain mixture fertilizer is produced with raw-material with granules of homogeneous size, within the variation of SGN ± 5%, it presents fewer segregation problems regardless the sampling points mentioned, according to what happened to the formula 12-15-15, and the use of certain raw-material with granules which are incompatible to the other components in the mixture, lead to condenation of the product both chemically and granulometrically, according to what happened to the formula 02-30-10. The compound sample method proved itself efficient despite failing the granulometric analysis of the formula 02-30-10 (after packaging and transportation for 696 km), due to greater amount, size and round format of the triple superphosphate granules (TSP).
Os fertilizantes minerais utilizados no Brasil são em sua grande maioria comercializados na forma de misturas de grânulos por propiciar, menores custos de armazenamento e transporte, além de apresentarem menor possibilidade de empedramento, maior facilidade de manuseio, simplificando a sua aplicação. Apesar das vantagens citadas, estas misturas, que podem apresentar dois ou três macronutrientes primários, macronutrientes secundários e micronutrientes, é de fundamental importância que os nutrientes estejam uniformemente distribuídos em todo o seu volume, para que haja uma distribuição homogênea na área de cultivo. Contudo, neste tipo de mistura podem ocorrer problemas de heterogeneidade pela segregação dos grânulos que também resultará na separação dos nutrientes, ocasionando uma aplicação irregular. A segregação é preocupante tanto do ponto de vista da aplicação do fertilizante, quanto do momento da amostragem por parte da fiscalização, podendo obter um resultado de análise que não corresponde à realidade da composição do produto. O volume de fertilizantes acondicionado em embalagem Big Bag impossibilita aos fiscais a homogeneização do produto previamente à amostragem, como é estabelecido pela legislação, no caso de embalagens menores, necessitando, portanto de uma metodologia de amostragem apropriada. Diante destes fatos, com o objetivo de avaliar a segregação de fertilizantes e determinar uma metodologia de amostragem para embalagem tipo Big Bag foi desenvolvido um estudo com duas fórmulas 02-30-10 e 12-15-15 acondicionadas em quatro Big Bag cada uma. Foram estabelecidas amostragens em três momentos distintos, sendo uma logo após o envase, outra após os Big Bags terem sido transportados em caminhão por 407 Km e a última após completar 696 Km, realizados em estradas de asfalto e de terra. Foi utilizada uma sonda de aço inox cano duplo com ponta cônica, para amostragem de cinco níveis distintos na horizontal, cinco no sentido vertical, uma no centro e em cada um dos cantos da embalagem e uma na diagonal, as quais individualmente foram acondicionadas para análise química e granulométrica. Retirou-se também uma amostra composta, que foi feita inserindo verticalmente a sonda em cada Big Bag em três pontos distintos, e depois foram juntadas as porções das quatro embalagens para a realização das análises. Os resultados das análises químicas e de granulometria, nos vários pontos de amostragens realizados na vertical, horizontal, diagonal, e composta, após o envase e os transportes dos Big Bag, nas duas fórmulas pesquisadas, nos indicam que se um fertilizante mistura de grânulos for elaborado com matérias-primas com grânulos de tamanhos homogêneos, dentro da variação de ± 5% do SGN, apresentam menores problemas de segregação independente dos pontos de amostragens citados, conforme o ocorrido com a fórmula 12-15-15, e o uso de determinada matéria-prima com grânulos incompatíveis aos demais componentes da mistura, levam à condenação do produto tanto química quanto granulometricamente, conforme o ocorrido com a fórmula 02- 30-10. O método de amostra composta mostrou ser eficiente apesar da reprovação granulométrica da formulação 02-30-10 (após envase e transporte de 696 km), fato justificado pela maior quantidade, tamanho e formato arredondado dos grânulos do superfosfato triplo (TSP).

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Zhang, Min. « The role of SWI/SNF in regulating smooth muscle differentiation ». Thesis, Connect to resource online, 2009. http://hdl.handle.net/1805/2024.

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Thesis (Ph.D.)--Indiana University, 2009.
Title from screen (viewed on December 1, 2009). Department of Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): B. Paul Herring, Anthony B. Firulli, Frederick M. Pavalko, Simon J. Rhodes. Includes vitae. Includes bibliographical references (leaves 138-149).

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AQUINO, SIBELE DIAS DE. « PSYCHOLOGY AT SHOPPING BAG : RELATIONS BETWEEN BIG FIVE, SOCIAL INFLUENCE AND IMPULSE BUYING ». PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2018. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=35833@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO
COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTITUIÇÕES COMUNITÁRIAS DE ENSINO PARTICULARES
A compra por impulso acontece sem reflexão, espontaneamente, e pode ter vários antecedentes. O objetivo desta dissertação foi testar o poder preditivo dos cinco grandes fatores de personalidade sobre a compra por impulso. Para tanto, realizaram-se dois estudos em que 1296 brasileiros, de todos os estados da federação, responderam a um questionário via internet. O estudo 1 teve o objetivo de buscar evidências de validade de um instrumento para aferir a tendência de comprar impulsivamente. Foram encontradas correlações positivas entre a tendência de comprar por impulso, a influência social normativa e traços de impulsividade do consumidor. O instrumento também foi capaz de diferenciar pessoas que fazem lista de compras das que não fazem, e pessoas que preferem ir às compras sozinhas das que preferem comprar acompanhadas. As evidências encontradas suportam o uso do instrumento para o contexto brasileiro. No segundo estudo, foi realizada uma regressão linear múltipla para testar se personalidade e influência social prediriam a compra por impulso. As variáveis investigadas explicaram 23 por cento da variância da compra por impulso. Entre preditores significativos positivos destacaram-se a influência social normativa e o fator de Neuroticismo de personalidade; entre os negativos, destacaram-se o hábito de fazer lista de compra e o fator Conscienciosidade de personalidade. Os resultados confirmam o poder preditivo de fatores de personalidade, influência social e hábitos de consumo sobre o comportamento de compra por impulso. Este estudo aprofunda os achados psicológicos sobre comportamentos de compra, alavancando a disseminação do conhecimento tanto para pesquisadores, quanto para profissionais interessados no tema.
The aim of this study was to test the predictive power of the big five factors of personality on impulse buying. In addition, sexual differences were verified for impulse buying behavior and levels of susceptibility to social influence, as well as relations of purchase with sociodemographic variables and consumption habits. Participants were 1296 Brazilians. The model tested explained 23 percent of the variance of impulse buying, the higher predictive powers were for normative influence and neuroticism, as positive; followed by the habit of making shopping list and conscientiousness, as negative predictors. The results confirm the predictive power of personality factors, consumption habits and socio-demographic variables on impulse buying.

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Keenen, Bridget. « The Role of SWI/SNF Chromatin Remodeling Complex in Melanoma ». University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1271819328.

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Holm, Anders Larsen Flemming. « To samtidige Kirkegaards og Grundtvigs kritik af hinanden / ». Kbh. : Nota, 2009. http://www.e17.dk/bog/18730.

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Livres sur le sujet "BRG"

Group, Business Resources, dir. BRG/bibliography : An indexed guide to environmental statistics on electronic media. Takoma Park, Md. (7910 Longbranch Pkwy., Takoma Park 20912) : Business Resources Group, 1992.

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Kurtulan, Banu. Zur Geschichte der jüdischen Schüler des RG 18, 1938 : Fachbereichsarbeit aus Geschichte BRG 18, 1994. Wien : Reinhart Sellner, 1994.

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Krištof, Franc. Jubilejni zbornik '97 : 40 let Slovenske gimnazije v Celovcu = 40 jahre BG und BRG für Slowenen in Klagenfurt. Klagenfurt : Rvnateljstvo ZG in ZRG za Slovence, 1997.

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Root, Phyllis. Big belching bog. Minneapolis : University of Minnesota Press, 2010.

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Geisel, Ted. The big brag. New York : Random House, 1998.

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Roald, Dahl, dir. The BFG (big friendly giant). London : S. French, 1991.

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French, Vivian. The hedgehogs and the big bag. London : Puffin, 1994.

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ill, Hafner Marylin, dir. M & M and the big bag. [New York] : Puffin Books, 1985.

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ill, Jessell Tim, dir. A night in Santa's great big bag. New York : Viking Children's Books, 2010.

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Kladstrup, Kristin. A night in Santa's great big bag. New York : Viking, 2010.

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Chapitres de livres sur le sujet "BRG"

Centlivre, Mireille, Nicolas Legrand et Ben Berkhout. « A Conditionally Replicating Human Immunodeficiency Virus in BRG-HIS Mice ». Dans Humanized Mice for HIV Research, 443–54. New York, NY : Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1655-9_35.

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Key, Mark. « Introduction ». Dans Building Regulations, Codes and Standards, 1–10. London : ICE Publishing, 2022. http://dx.doi.org/10.1680/brs.65352.001.

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Key, Mark. « A brief history of building control in England ». Dans Building Regulations, Codes and Standards, 11–29. London : ICE Publishing, 2022. http://dx.doi.org/10.1680/brs.65352.011.

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Key, Mark. « The Building Regulations 2010 : functional requirements and technical solutions ». Dans Building Regulations, Codes and Standards, 63–87. London : ICE Publishing, 2022. http://dx.doi.org/10.1680/brs.65352.063.

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Key, Mark. « Building standards and the skills gap ». Dans Building Regulations, Codes and Standards, 187–96. London : ICE Publishing, 2022. http://dx.doi.org/10.1680/brs.65352.187.

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Key, Mark. « The importance of safe, sustainable and healthy development ». Dans Building Regulations, Codes and Standards, 141–65. London : ICE Publishing, 2022. http://dx.doi.org/10.1680/brs.65352.141.

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Key, Mark. « Concluding observations ». Dans Building Regulations, Codes and Standards, 197–99. London : ICE Publishing, 2022. http://dx.doi.org/10.1680/brs.65352.197.

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Key, Mark. « Voluntary building rating schemes ». Dans Building Regulations, Codes and Standards, 113–39. London : ICE Publishing, 2022. http://dx.doi.org/10.1680/brs.65352.113.

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Key, Mark. « The Building Regulations 2010 : legislative and procedural issues ». Dans Building Regulations, Codes and Standards, 31–62. London : ICE Publishing, 2022. http://dx.doi.org/10.1680/brs.65352.031.

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Key, Mark. « International regulations, codes and standards ». Dans Building Regulations, Codes and Standards, 89–112. London : ICE Publishing, 2022. http://dx.doi.org/10.1680/brs.65352.089.

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Actes de conférences sur le sujet "BRG"

Vico, Hendro, Riezal Arieffiandhany, Indra Sanjaya, Lambertus Francisco, Yasinta Dewi Setiawati, Budi Rivai Wijaya, Agung Arief Wijaya, Andhika Pratama, Arifin Isawiseman et Edi Kadra Wijaya. « Scale Squeeze Inhibitor as Preventive Treatment in Brani Wells, Offshore North West Java ». Dans SPE/IATMI Asia Pacific Oil & Gas Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/205564-ms.

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Abstract The Brani-Field is located offshore Northwest Java and currently produces hydrocarbons from a sandstone reservoir with an average watercut of 83%. Some high watercut wells are prone to scale problems and need repetitive clean outs to overcome production decline. In 2019, downhole scale inhibitor treatment was evaluated and planned for application in these wells. Scale inhibitors are able to prevent the formation of scale so the well is able to deliver higher average oil production with lower intervention cost. In Brani wells, scale deposits are formed in perforations, downhole completion equipment, and flowlines depending on the water composition, temperature, and a reduction in dissolved carbon dioxide partial pressure. These scales deposits restrict the fluid flow causing significant production loss. In extreme conditions, the production tubing was blocked completely with the scale deposits and cease the production. Normally, the scale restriction problem in Brani wells were handled by a combination of mechanical and acidizing treatment using Coiled Tubing (CT) for downhole completion and acidizing treatment for flowline restrictions. These treatment were performed periodically every 2-4 months depending on well conditions with scaling becoming more severe in higher watercut wells. From an economic standpoint, current scale treatment methods lead to very high well intervention costs due to expensive liftboat and CT unit daily rates. The economics of these conventional treatments is further deterred by low yearly average oil production. Evaluation for scale inhibitor treatment started with the candidate selection, fluids compatibility test, core re-gain permeability test, and economic evaluation. BRG-10 well was selected as first candidate due to scale problem severity and low oil production rate. This well normally delivers 140 bopd with 90% watercut, but scale build up in the tubing and flowline prevented the fluids flow and lowered the production to 30 bopd in just two months. Laboratory test results demonstrated that the core regained permeability with the main pill fluids to a relatively high, 77.96% without any fluids compatibility issues. Deployment of a scale inhibitor squeeze treatment in BRG-10 well was executed in Jan 2020 by bullheading 657 bbl inhibitor fluids into the formation. The well was then shut in for 24 hours of soaking time. The post treatment results showed a very promising result with much more stable oil production after 11 months treatment, welltest on December 2020 showed the well was still producing 130 bopd with 90% watercut. Following the successful application in BRG-10, the scale inhibitor treatment was applied in other wells, BRK-7 in June 2020 and BRG-5L in August 2020. So far, those two wells show good production performance with 93 bopd with 85% watercut for BRK-7 and 264 bopd with 76% for BRG-5L.

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Cho, J., J. K. Woo, J. Yan, R. L. Peterson et K. Najafi. « A high-Q birdbath resonator gyroscope (BRG) ». Dans 2013 Transducers & Eurosensors XXVII : The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII). IEEE, 2013. http://dx.doi.org/10.1109/transducers.2013.6627150.

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Cho, Jae Yoong, J. K. Woo, Guohong He, Donguk Yang, Christopher Boyd, Sajal Singh, Ali Darvishian, Behrouz Shiari et Khalil Najafi. « 1.5-Million Q-Factor Vacuum-Packaged Birdbath Resonator Gyroscope (BRG) ». Dans 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2019. http://dx.doi.org/10.1109/memsys.2019.8870889.

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Woo, Jong-Kwan, Jae Yoong Cho, Christopher Boyd et Khalil Najafi. « Whole-angle-mode micromachined fused-silica birdbath resonator gyroscope (WA-BRG) ». Dans 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2014. http://dx.doi.org/10.1109/memsys.2014.6765563.

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Matsubara, Daisuke, Yuka Kishaba, Shumpei Ishikawa, Masashi Fukayama et Toshiro Niki. « Abstract 2179 : Histopathologic and genetic features of lung adenocarcinomas with loss of chromatin remodeling factors, BRG-1 and BRM ». Dans Proceedings : AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012 ; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2179.

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Braghin, Francesco, Paolo Pennacchi et Edoardo Sabbioni. « Evaluation of Human Body Dynamical Behaviour During Handling Maneuvers and Crash Test Simulations Using Multi-Body Codes ». Dans ASME 8th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2006. http://dx.doi.org/10.1115/esda2006-95490.

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The dynamic behavior of the human body during race car maneuvers and frontal crash tests is analyzed in this paper. Both the vehicle and the human body have been modeled using the multi-body approach. Two commercial codes, BRG LifeMOD Biomechanics Modeler®, for the simulation of the human body dynamics, and MSC ADAMS/Car® for the modeling of the vehicle behavior, have been used for the purpose. Due to the impossibility of co-simulating, at first the accelerations on the driver’s chassis are determined using the vehicle’s multibody code and approximating the driver as a rigid body. Then, the calculated accelerations are applied to the vehicle chassis in the biomechanics code to assess the accelerations in various significant points on the driver.

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Umar et Naufal Afif Murtadho. « Analysis voltage drop and alternative network manuvers in BRG-4 recovery PT. PLN (Persero) Salatiga service unit using etap power station 12.6 ». Dans EXPLORING RESOURCES, PROCESS AND DESIGN FOR SUSTAINABLE URBAN DEVELOPMENT : Proceedings of the 5th International Conference on Engineering, Technology, and Industrial Application (ICETIA) 2018. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5112465.

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Viana, Lorena da Silva, Ellen Larissa Santos da Rocha Maciel, Karem Stephany Assunção Folgado, Juliene do Nascimento Sousa da Silva et Júlio César Queiroz de França. « BLOQUEIO DE RAMO ALTERNANTE ASSOCIADO À OCORRÊNCIA DE SÍNCOPE : UMA RARA CONDIÇÃO CLÍNICA ». Dans 1° Congresso Sul Maranhense de Cardiologia. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/csmc/02.

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INTRODUÇÃO: O transtorno de condução no feixe de His caracteriza o bloqueio deramo, normalmente relacionado a apenas um dos ramos, direito ou esquerdo. Entretanto, existe uma condição incomum chamada de bloqueio de ramo alternante (BRA), em que há uma alternância entre bloqueio de ramo direito (BRD) e bloqueio de ramo esquerdo (BRE) em um mesmo eletrocardiograma (ECG). A associação dessa condição com síncopes, pré-síncopes ou tonturas recorrentes apresenta maiores chances de fatalidade. METODOLOGIA: A coleta de dados foi realizada por anamnese e análise de prontuário do paciente no dia 15/04/2022. O Termo de Consentimento Livre e Esclarecido foi assinado pelo paciente. RELATO: Paciente, 47 anos, masculino, foi internado com história de alteração de marcha, tontura, náuseas e episódio de síncope. Nega histórico pessoal ou familiar de doenças cardiovasculares, tabagismo e etilismo. Relata alimentação adequada e prática regular de atividade física. Ao exame físico apresentava pressão arterial 110X80mmHg e semiologia cardiovascular e respiratória normais. Foi encaminhado para realização de ECG e RNM de crânio, essa sem alterações. Ao primeiro ECG, foi evidenciado BRD. Três dias depois foi realizado um novo ECG que evidenciou BRE. Paciente evoluiu bem e foi encaminhado para realização de um ecocardiograma transtorácico, que constatou ausência de disfunção ventricular. Ademais, efetuou-se um cateterismo cardíaco que mostrou ausência de coronariopatia e/ou disfunção ventricular esquerda. Além disso, a sorologia para Doença de Chagas veio negativa e o paciente não apresentava distúrbio hidroeletrolítico. Após quinze dias de internação, durante outro episódio de pré-síncope, um novo ECG foi realizado, apontando novamente um BRD. Foi solicitado Holter ECG de 24h que constatou BRE fixo nas 24 horas. Diante do distúrbio de condução grave e a ocorrência de síncope, foi realizado um implante de marcapasso definitivo, que ocorreu 17 dias após a internação. Após 30 dias, o paciente retornou ao ambulatório assintomático e sem alterações no funcionamento do dispositivo. CONCLUSÃO: O bloqueio de ramo alternante é raro e com diversas etiologias, incluindo idiopática. Para o diagnóstico, foi essencial a realização do ECG e Holter ECG de 24 horas. Diante do potencial mau prognóstico do quadro, sobretudo pela associação com síncope, a implantação de marca-passo definitivo foi necessária.

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Wang, W., C. Zhang et L. Liu. « Large Size Fe-Based Bulk Metallic Glass Composite Prepared by Additive Manufacturing via HVOF Thermal Spraying ». Dans ITSC2017, sous la direction de A. Agarwal, G. Bolelli, A. Concustell, Y. C. Lau, A. McDonald, F. L. Toma, E. Turunen et C. A. Widener. DVS Media GmbH, 2017. http://dx.doi.org/10.31399/asm.cp.itsc2017p0729.

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Abstract Bulk metallic glasses (BMGs) are a novel class of metallic materials with disordering atomic structure and excellent mechanical and chemical properties, and are promising for various industry applications. BMGs are usually fabricated by copper-mould casting due to the requirement of fast cooling rate for the obtainment of amorphous structure. However, this casting approach has the limitation for preparation of large size samples (the biggest Fe-based BMG obtained so far is less than 16 mm diameter). In this work, the conventional high velocity oxy-fuel (HVOF) thermal spraying technique was utilized as a novel additive manufacturing route to create large size Fe-based BMGs and BMG composites. It will be reported that a large size of 20x20x20mm BMG (Fe48Mo14Cr15Y2C15B6 (at%) ) and big plate of 100×100×5 mm of Fe-based BMG composites reinforced with 50vol% 316L stainless steel powders was successfully prepared by HVOF thermal spraying. Both BMG and BMG composite showed very dense structure (porosity less than 0.4% ) and good mechanical properties, Especially, BMG composite reinforced with 316 L stainless steel exhibited a yield strength of 1.8 GPa and compressive plastic strain of 2%. More importantly, this Fe-based BMG composite exhibited good toughness of KJ=21 MPa m1/2, which is almost 4-times higher than that of as-cast BMG. This present work indicates that HVOF thermal spray can become a versatile technique for preparation of large size of bulk metallic glasses and composites with desired properties.

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Wu, Cheyu, Ching-Te Chiu et Yar-Sun Hsu. « Object recognition using bag of words with kernels for big data ». Dans 2014 IEEE International Conference on Consumer Electronics - Taiwan (ICCE-TW). IEEE, 2014. http://dx.doi.org/10.1109/icce-tw.2014.6904114.

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Rapports d'organisations sur le sujet "BRG"

Muzika, Rose-Marie, Robert Hunsucker et Tom DeMeo. Botanical reconnaissance of Big Run Bog candidate research natural area. Radnor, PA : U.S. Department of Agriculture, Forest Service, Northeastern Forest Experimental Station, 1996. http://dx.doi.org/10.2737/ne-gtr-223.

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Savaldi-Goldstein, Sigal, et Todd C. Mockler. Precise Mapping of Growth Hormone Effects by Cell-Specific Gene Activation Response. United States Department of Agriculture, décembre 2012. http://dx.doi.org/10.32747/2012.7699849.bard.

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Plant yield largely depends on a complex interplay and feedback mechanisms of distinct hormonal pathways. Over the past decade great progress has been made in elucidating the global molecular mechanisms by which each hormone is produced and perceived. However, our knowledge of how interactions between hormonal pathways are spatially and temporally regulated remains rudimentary. For example, we have demonstrated that although the BR receptor BRI1 is widely expressed, the perception of BRs in epidermal cells is sufficient to control whole-organ growth. Supported by additional recent works, it is apparent that hormones are acting in selected cells of the plant body to regulate organ growth, and furthermore, that local cell-cell communication is an important mechanism. In this proposal our goals were to identify the global profile of translated genes in response to BR stimulation and depletion in specific tissues in Arabidopsis; determine the spatio-temporal dependency of BR response on auxin transport and signaling and construct an interactive public website that will provide an integrated analysis of the data set. Our technology incorporated cell-specific polysome isolation and sequencing using the Solexa technology. In the first aim, we generated and confirmed the specificity of novel transgenic lines expressing tagged ribosomal protein in various cell types in the Arabidopsis primary root. We next crossed these lines to lines with targeted expression of BRI1 in the bri1 background. All lines were treated with BRs for two time points. The RNA-seq of their corresponding immunopurified polysomal RNA is nearly completed and the bioinformatic analysis of the data set will be completed this year. Followed, we will construct an interactive public website (our third aim). In the second aim we started revealing how spatio-temporalBR activity impinges on auxin transport in the Arabidopsis primary root. We discovered the unexpected role of BRs in controlling the expression of specific auxin efflux carriers, post-transcriptionally (Hacham et al, 2012). We also showed that this regulation depends on the specific expression of BRI1 in the epidermis. This complex and long term effect of BRs on auxin transport led us to focus on high resolution analysis of the BR signaling per se. Taking together, our ongoing collaboration and synergistic expertise (hormone action and plant development (IL) and whole-genome scale data analysis (US)) enabled the establishment of a powerful system that will tell us how distinct cell types respond to local and systemic BR signal. BR research is of special agriculture importance since BR application and BR genetic modification have been shown to significantly increase crop yield and to play an important role in plant thermotolerance. Hence, our integrated dataset is valuable for improving crop traits without unwanted impairment of unrelated pathways, for example, establishing semi-dwarf stature to allow increased yield in high planting density, inducing erect leaves for better light capture and consequent biomass increase and plant resistance to abiotic stresses.

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Zepernick, David, Katrina Feilberg Schouenborg, Sarah Lindegaard et Mathias Wulff Jensen. Brug tøjet – Brug hovedet – Skån miljøet. Nordic Council of Ministers, novembre 2014. http://dx.doi.org/10.6027/na2014-922.

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Davis, John. LANL PVC bag-out-bag replacement. Office of Scientific and Technical Information (OSTI), février 2023. http://dx.doi.org/10.2172/1958964.

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Barner, Claudine Eckert, et Kristen Morris. Newton Bra. Ames : Iowa State University, Digital Repository, septembre 2016. http://dx.doi.org/10.31274/itaa_proceedings-180814-1610.

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Cox, Lydia, Gernot Müller, Ernesto Pastén, Raphael Schoenle et Michael Weber. Big G. Cambridge, MA : National Bureau of Economic Research, avril 2020. http://dx.doi.org/10.3386/w27034.

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Gawade, Rushikesh. Big data and big dollars are changing cricket. Sous la direction de Chris Bartlett. Monash University, février 2023. http://dx.doi.org/10.54377/783a-d051.

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Mishkin, Frederic. How Big a Problem is Too Big to Fail ? Cambridge, MA : National Bureau of Economic Research, décembre 2005. http://dx.doi.org/10.3386/w11814.

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Zwitter, Andrej J., et Amelia Hadfield. Governing Big Data. Librello, janvier 2014. http://dx.doi.org/10.12924/pag2014.02010001.

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