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Articles de revues sur le sujet « C-reactive protein Autoimmune Omega-3 fatty acid High-senstive CRP »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

I, Kadek Sumantara Artha, and Agung Ayu Ratih Dharmaiswari Anak. "The Correlation of Omega-3 Supplementation with CRP As Marker Inflammation in Autoimmune Diseases." International Journal of Medical Science and Clinical Research Studies 5, no. 05 (2025): 686–95. https://doi.org/10.5281/zenodo.15347928.

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Introduction: Omega-3 fatty acids are a type of polyunsaturated fatty acids (PUFAs) are regarded as anti-inflammatory lipids. The occurrence of diseases with an inflammatory aspect, including acute myocardial infarction, diabetes mellitus, autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), psoriasis vulgaris, type 1 diabetes mellitus (T1DM), inflammatory bowel diseases (IBD) and systemic lupus erythematosus (SLE). Omega 3 can reduce inflammatory factor such as CRP (C- reactive protein) or hsCRP (High sensitive c-reactive protein). Objective: This systematic review

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Dong, Yanbin, Haidong Zhu, Li Chen, et al. "Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL Randomized Trial." Nutrients 14, no. 24 (2022): 5307. http://dx.doi.org/10.3390/nu14245307.

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Background: The VITAL study was a nationwide, randomized, double-blind, placebo-controlled, 2 × 2 factorial trial of vitamin D3 (2000 IU/day) and marine n-3 FAs (1 g/day) supplements. We recently reported that vitamin D supplementation with or without omega 3 fatty acids reduced autoimmune disease by 22% in the VITAL study. Objective: To investigate the effects of vitamin D3 and/or n-3 FAs on changes in systemic inflammatory biomarkers including pro- and anti-inflammatory cytokines over a 4-year period in the VITAL sub-cohort with in-person evaluations at the Center for Clinical Investigations

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Perez-Sanchez, C., L. Muñoz-Barrera, T. Cerdó, et al. "POS1041 LIPID METABOLISM IS DEEPLY ALTERED IN ACTIVE RHEUMATOID ARTHRITIS PATIENTS AND REVERSED BY ANTI-TNF, ANTI-IL6R, AND JAK-INHIBITORS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 838.1–838. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3821.

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BackgroundSince lipid metabolism impact immune cell plasticity regulating cell activation, differentiation and function, the extensive analysis of the lipidomic profile using novel high-throughput metabolomic techniques in chronic inflammatory diseases such as Rheumatoid Arthritis (RA) might contribute to better characterise the pathogenesis of the disease.ObjectivesTo analyse the whole lipidomic profile in the serum of RA patients, its association with the disease activity and its modulation by biological and targeted synthetic therapies.MethodsTwo hundred and fifty consecutive RA patients we

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Megawati, Ginna, Noormarina Indraswari, Alexandra Aurelia Johansyah, et al. "Comparison of hs-CRP in Adult Obesity and Central Obesity in Indonesia Based on Omega-3 Fatty Acids Intake: Indonesian Family Life Survey 5 (IFLS 5) Study." International Journal of Environmental Research and Public Health 20, no. 18 (2023): 6734. http://dx.doi.org/10.3390/ijerph20186734.

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Obesity and central obesity are associated with dire conditions, such as metabolic syndrome, in which low-grade inflammation plays a part. C-reactive protein (CRP) is an inflammatory marker found to be elevated in those conditions. Omega-3 fatty acids work against inflammation and lower CRP levels in obese individuals. This study compared high-sensitivity CRP (hs-CRP) in adult obesity and central obesity in Indonesia based on omega-3 fatty acid intake using Indonesian Family Life Survey (IFLS) 5 data. Secondary data from household questionnaires were obtained from the IFLS 5 online database. D

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Lindahl, *Jesper, Klara Suneson, Gustav Söderberg, et al. "OMEGA-3 FATTY ACIDS FOR INFLAMED DEPRESSION – A MATCH/MISMATCH STUDY." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i195. https://doi.org/10.1093/ijnp/pyae059.338.

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Abstract Background Despite decades of research on the pathophysiology of depression, the development of new therapeutic interventions has been slow, and no biomarkers of treatment response have been clinically implemented. Several lines of evidence suggets that the clinical and biological heterogeneity among patients with major depressive disorder (MDD) has hampered progress in this field. MDD with low-grade inflammation - "inflamed depression" - is a subtype of depression that may be associated with the superior antidepressant treatment response to anti-inflammatory compounds. Omega-3 fatty

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Jafari Salim, Shirin, Shahab Alizadeh, Mahmoud Djalali, Ebrahim Nematipour, and Mohammad Hassan Javanbakht. "Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical Trial." American Journal of Men's Health 11, no. 6 (2017): 1758–64. http://dx.doi.org/10.1177/1557988317720581.

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Adipokines are mediators of body composition and are involved in obesity-related complications such as cardiovascular disease. Omega-3 supplementation has not been studied in the setting of body composition and follistatin-like 1 (FSTL1) levels in patients with coronary artery disease (CAD). This study aimed to investigate the effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition indices and serum levels of FSTL1 in CAD patients. A total of 42 male (aged 45–65 years) subjects with angiographically confirmed CAD were included in this randomized, double-blin

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Kopp, Lena, Anna Schweinlin, Lina Tingö, et al. "Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial." International Journal of Molecular Sciences 24, no. 10 (2023): 8567. http://dx.doi.org/10.3390/ijms24108567.

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Obesity is characterized by low-grade inflammation and increased gut permeability. Here, we aim to evaluate the effect of a nutritional supplement on these parameters in subjects with overweight and obesity. A double-blinded, randomized clinical trial was conducted in 76 adults with overweight or obesity (BMI 28 to 40) and low-grade inflammation (high-sensitivity C-reactive protein (hs-CRP) between 2 and 10 mg/L). The intervention consisted of a daily intake of a multi-strain probiotic of Lactobacillus and Bifidobacterium, 640 mg of omega-3 fatty acids (n-3 FAs), and 200 IU of vitamin D (n = 3

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Simopoulos, Artemis P. "Genetic Variation, Diet, Inflammation, and the Risk for COVID-19." Lifestyle Genomics 14, no. 2 (2021): 37–42. http://dx.doi.org/10.1159/000513886.

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COVID-19, which is caused by SARS-CoV-2, is characterized by various symptoms, ranging from mild fatigue to life-threatening pneumonia, “cytokine storm,” and multiorgan failure. The manifestation of COVID-19 may lead to a cytokine storm, i.e., it facilitates viral replication that triggers a strong release of cytokines, which then modulates the immune system and results in hyperinflammation. Today’s diet is high in omega-6 fatty acids and deficient in omega-3 fatty acids; this, along with a high fructose intake, leads to obesity, which is a chronic state of low-grade inflammation. Omega-6 fatt

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Lin, Ya-Ling, Chia-Liang Wang, Kai-Li Liu, Cheng-Nan Yeh, and Tsay-I. Chiang. "Omega-3 Fatty Acids Improve Chronic Kidney Disease—Associated Pruritus and Inflammation." Medicina 58, no. 6 (2022): 796. http://dx.doi.org/10.3390/medicina58060796.

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Background and Objectives: Chronic kidney disease-associated pruritus (CKD-aP) is a common symptom in hemodialysis patients. A frequent and intense itching sensation largely torments patients, impacts quality of life outcomes, and it has an independent association with mortality. The objective of this study is to investigate the effects of oral supplementation with omega-3 polyunsaturated fatty acid (omega-3 PUFA) on circulating interleukin-6 (IL-6), cardiometabolic parameters, skin moisturization, and the consequent symptoms of pruritus in hemodialysis patients. Materials and Methods: Volunte

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Sony Sanjaya, Febria Suryani, Pham Uyen, Maria Rodriguez, and Muhammad Yoshandi. "Preventing Cognitive Decline in Late-Life Depression: A Longitudinal Study on the Efficacy of Omega-3 Fatty Acid Supplementation in Older Adults in Palembang, Indonesia." Scientia Psychiatrica 6, no. 2 (2025): 736–47. https://doi.org/10.37275/scipsy.v6i2.190.

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Introduction: Late-life depression (LLD) is a prevalent condition in older adults and a significant risk factor for cognitive decline and dementia. In Indonesia, with its aging population and specific dietary patterns, understanding interventions for LLD-associated cognitive impairment is crucial. Omega-3 polyunsaturated fatty acids (PUFAs) offer potential neuroprotective benefits. This study aimed to assess the efficacy of long-term omega-3 PUFA supplementation in mitigating cognitive decline among older adults with LLD in Palembang, Indonesia. Methods: This 24-month, randomized, double-blind

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Johnson, Kylie M., Kellie R. Weinhold, Rebecca Andridge, Kristen Arnold, Panchita P. Chu, and Tonya S. Orchard. "Associations of Erythrocyte Polyunsaturated Fatty Acids with Inflammation and Quality of Life in Post-Menopausal Women with Obesity Completing a Pilot Dietary Intervention." Nutrients 11, no. 7 (2019): 1589. http://dx.doi.org/10.3390/nu11071589.

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Study objectives were to determine if erythrocyte omega-3 polyunsaturated fatty acids (n-3 PUFAs) increased in women participating in a dietary intervention that reduced inflammation and body weight and examine PUFA associations with markers of inflammation and quality of life (QOL). An experimental pre-post test, single group design was used. Fifteen post-menopausal women with obesity were enrolled in a 12-week pilot intervention focusing on lowering added sugars and increasing fiber and fish rich in n-3 PUFAs. Measurements included fasting blood samples, anthropometric, lifestyle and dietary

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de Mello, Vanessa Derenji, Tuomas Selander, Jaana Lindström, Jaakko Tuomilehto, Matti Uusitupa, and Kai Kaarniranta. "Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study." Nutrients 13, no. 12 (2021): 4452. http://dx.doi.org/10.3390/nu13124452.

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Diabetic retinopathy (DR) is the most common microvascular complication of diabetes, and retinal microaneurysms (MA) are one of the first detected abnormalities associated with DR. We recently showed elevated serum triglyceride levels to be associated with the development of MA in the Finnish Diabetes Prevention Study (DPS). The purpose of this metabolomics study was to assess whether serum fatty acid (FA) composition, plasmalogens, and low-grade inflammation may enhance or decrease the risk of MA. Originally, the DPS included 522 individuals (mean 55 years old, range 40–64 years) with impaire

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Khalili, Leila, Roxana Valdes-Ramos, and Laurence S. Harbige. "Effect of n-3 (Omega-3) Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers and Body Weight in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of RCTs." Metabolites 11, no. 11 (2021): 742. http://dx.doi.org/10.3390/metabo11110742.

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Beneficial effects of n-3 fatty acids on metabolic biomarkers in patients with type 2 diabetes (T2DM) has been reported. The objectives of this current research were to investigate the effects of n-3 supplementation on metabolic factors, weight, and body mass index (BMI) in patients with type 2 diabetes mellitus (T2DM), using a meta-analysis of randomized, controlled trials (RCTs). Online databases PubMed, Embase, Web of Science, and Science Direct were searched until 2021 to identify eligible articles. Thirty trials were included. The results showed that n-3 consumption can significantly redu

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Artha, I. Kadek Sumantara, and Anak Agung Ayu Ratih Dharmaiswari. "The Correlation of Omega-3 Supplementation with CRP As Marker Inflammation in Autoimmune Diseases." International Journal of Medical Science and Clinical Research Studies 05, no. 05 (2025). https://doi.org/10.47191/ijmscrs/v5-i05-03.

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Introduction: Omega-3 fatty acids are a type of polyunsaturated fatty acids (PUFAs) are regarded as anti-inflammatory lipids. The occurrence of diseases with an inflammatory aspect, including acute myocardial infarction, diabetes mellitus, autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), psoriasis vulgaris, type 1 diabetes mellitus (T1DM), inflammatory bowel diseases (IBD) and systemic lupus erythematosus (SLE). Omega 3 can reduce inflammatory factor such as CRP (C- reactive protein) or hsCRP (High sensitive c-reactive protein). Objective: This systematic review

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Elisia, Ingrid, Michelle Yeung, Sara Kowalski, et al. "Omega 3 supplementation reduces C-reactive protein, prostaglandin E2 and the granulocyte/lymphocyte ratio in heavy smokers: An open-label randomized crossover trial." Frontiers in Nutrition 9 (December 1, 2022). http://dx.doi.org/10.3389/fnut.2022.1051418.

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ObjectivesGiven the current controversy concerning the efficacy of omega 3 supplements at reducing inflammation, we evaluated the safety and efficacy of omega 3 on reducing inflammation in people with a 6-year lung cancer risk &gt;1.5% and a C reactive protein (CRP) level &gt;2 mg/L in a phase IIa cross-over study.Materials and methodsForty-nine healthy participants ages 55 to 80, who were still smoking or had smoked in the past with ≥30 pack-years smoking history, living in British Columbia, Canada, were randomized in an open-label trial to receive 2.4 g eicosapentaenoic acid (EPA) +

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Suneson, Klara, Filip Ängeby, Jesper Lindahl, Gustav Söderberg, Johanna Tjernberg, and Daniel Lindqvist. "Efficacy of eicosapentaenoic acid in inflammatory depression: study protocol for a match-mismatch trial." BMC Psychiatry 22, no. 1 (2022). http://dx.doi.org/10.1186/s12888-022-04430-z.

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Abstract Background Most antidepressant treatment studies have included patients strictly based on the Diagnostic and Statistical Manual of Mental Disorders definition of Major Depressive Disorder (MDD). Given the heterogeneity of MDD, this approach may have obscured inter-patient differences and hampered the development of novel and targeted treatment strategies. An alternative strategy is to use biomarkers to delineate endophenotypes of depression and test if these can be targeted via mechanism-based interventions. Several lines of evidence suggest that “inflammatory depression” is a clini

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Bertoni, Camilla, Alessandra Mazzocchi, Ludovica Leone, Carlo Agostoni, and Giovanni Filocamo. "Cardiovascular risk and inflammation in a population with autoimmune diseases: a narrative review." Frontiers in Immunology 15 (March 28, 2024). http://dx.doi.org/10.3389/fimmu.2024.1380372.

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Juvenile Systemic Connective Tissue Diseases (JSCTD) are a heterogeneous group of chronic autoimmune diseases, associated with dyslipidemia and increased cardiovascular risk are related. Studies from the last 10 years, from 2013 to 2022, on lipid profiles in JSCTD were collected. Different studies on lipid profiles in children affected by JSCTD were selected, because the aim is to analyze the cardiovascular risk and the possibility of atherosclerosis in these patients in whom, sometimes, corticosteroid therapies and immunosuppressants increase the state of dyslipidemia. Several studies have sh

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Asbeutah, AbdulAziz A., Abdulaziz Malik, and Francine K. Welty. "Abstract 11150: The Effect of Eicosapentaenoic Acid and Docosahexaenoic Acid on Neutrophil/Lymphocyte Ratio, a Marker of Inflammation, in Subjects With Coronary Artery Disease: Results of a Randomized Trial." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.11150.

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Background: The neutrophil/lymphocyte (N/L) ratio increases with the systemic inflammatory response due to an increase in neutrophils and decrease in lymphocytes with systemic inflammation. An elevated N/L ratio has been associated with an increased risk of cardiovascular disease (CVD), cancer and mortality. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) decrease levels of high sensitivity C-reactive protein (hs-CRP), the gold standard inflammatory marker, when levels of hs-CRP are elevated. Randomized trials have also reported a decrease in CVD events with EPA. The mechanism for t

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Asghari, Kimia Motlagh, Parviz Saleh, Yaghoub Salekzamani, Neda Dolatkhah, Naser Aghamohammadzadeh, and Maryam Hashemian. "The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial." Nutrition & Diabetes 14, no. 1 (2024). http://dx.doi.org/10.1038/s41387-024-00274-6.

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Abstract Background/objectives The present study investigated the effect of curcumin and eicosapentaenoic acid, as one the main components of omega-3 polyunsaturated fatty acids, on anthropometric, glucose homeostasis, and gene expression markers of cardio-metabolic risk in patients with type 2 diabetes mellitus. Subjects/methods This clinical trial was conducted at the Endocrinology Clinic of Imam Reza Hospital in Tabriz. It aimed to determine the impact of Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), and curcumin supplements on various health indicators in patients with Type 2 Di

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Li, Ruiyao, Yao Wang, Jing Xu, Jiahao Yu, and Bin Li. "Effects of n-3 Polyunsaturated Fatty Acid Supplementation on Cardiovascular Indices in Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials." Reviews in Cardiovascular Medicine 26, no. 2 (2025). https://doi.org/10.31083/rcm25882.

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Background: Individuals with type 2 diabetes (T2DM) face a significantly increased risk of cardiovascular disease. This study aims to explore the impact of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular indices in this population. Although the benefits of n-3 PUFAs on cardiovascular health and glycemic outcomes are highly regarded, previous research reports have shown inconsistent results. Therefore, a comprehensive meta-analysis is needed to gain a deeper understanding of the specific effects of n-3 PUFAs on patients with T2DM. To examine the effect of n-3 PUFAs on cardiova

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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