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Littérature scientifique sur le sujet « Caveoli-1 (Cav1) »

Auteur : Grafiati

Publié le 5 avril 2025

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Articles de revues sur le sujet "Caveoli-1 (Cav1)"

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Li, Zhen, Shu Feng, Vanessa Lopez, et al. "Uterine Cysts in Female Mice Deficient for Caveolin-1 and Insulin-Like 3 Receptor RXFP2." Endocrinology 152, no. 6 (2011): 2474–82. http://dx.doi.org/10.1210/en.2010-1015.

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Gene mutations of insulin-like 3 (INSL3) peptide or its G protein-coupled receptor RXFP2 (relaxin family peptide receptor 2) lead to cryptorchidism. The role of INSL3 in adult females is less known, although INSL3 expression has been described in female reproductive organs. Caveolin-1 (CAV1), the main component of caveoli cell membrane invaginations, has been shown to play an important role in epithelial organization and stromal-epithelial interactions. We created a null allele of Cav1 mice by deleting its second exon through embryonic stem cell targeting. Immunohistochemical analysis demonstr

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Hayer, Arnold, Miriam Stoeber, Danilo Ritz, Sabrina Engel, Hemmo H. Meyer, and Ari Helenius. "Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation." Journal of Cell Biology 191, no. 3 (2010): 615–29. http://dx.doi.org/10.1083/jcb.201003086.

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Caveolae are long-lived plasma membrane microdomains composed of caveolins, cavins, and a cholesterol-rich membrane. Little is known about how caveolae disassemble and how their coat components are degraded. We studied the degradation of caveolin-1 (CAV1), a major caveolar protein, in CV1 cells. CAV1 was degraded very slowly, but turnover could be accelerated by compromising caveolae assembly. Now, CAV1 became detectable in late endosomes (LE) and lysosomes where it was degraded. Targeting to the degradative pathway required ubiquitination and the endosomal sorting complex required for transpo

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Joshi, Bharat, Michele Bastiani, Scott S. Strugnell, Cecile Boscher, Robert G. Parton, and Ivan R. Nabi. "Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation." Journal of Cell Biology 199, no. 3 (2012): 425–35. http://dx.doi.org/10.1083/jcb.201207089.

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Caveolin-1 (Cav1) is an essential component of caveolae whose Src kinase-dependent phosphorylation on tyrosine 14 (Y14) is associated with regulation of focal adhesion dynamics. However, the relationship between these disparate functions remains to be elucidated. Caveola biogenesis requires expression of both Cav1 and cavin-1, but Cav1Y14 phosphorylation is dispensable. In this paper, we show that Cav1 tyrosine phosphorylation induces caveola biogenesis via actin-dependent mechanotransduction and inactivation of the Egr1 (early growth response-1) transcription factor, relieving inhibition of e

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Jung, WooRam, Emma Sierecki, Michele Bastiani, et al. "Cell-free formation and interactome analysis of caveolae." Journal of Cell Biology 217, no. 6 (2018): 2141–65. http://dx.doi.org/10.1083/jcb.201707004.

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Caveolae have been linked to the regulation of signaling pathways in eukaryotic cells through direct interactions with caveolins. Here, we describe a cell-free system based on Leishmania tarentolae (Lt) extracts for the biogenesis of caveolae and show its use for single-molecule interaction studies. Insertion of expressed caveolin-1 (CAV1) into Lt membranes was analogous to that of caveolin in native membranes. Electron tomography showed that caveolins generate domains of precise size and curvature. Cell-free caveolae were used in quantitative assays to test the interaction of membrane-inserte

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Aravamudan, Bharathi, Sarah K. VanOosten, Lucas W. Meuchel, et al. "Caveolin-1 knockout mice exhibit airway hyperreactivity." American Journal of Physiology-Lung Cellular and Molecular Physiology 303, no. 8 (2012): L669—L681. http://dx.doi.org/10.1152/ajplung.00018.2012.

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Caveolae are flask-shaped plasma membrane invaginations expressing the scaffolding caveolin proteins. Although caveolins have been found in endothelium and epithelium (where they regulate nitric oxide synthase activity), their role in smooth muscle is still under investigation. We and others have previously shown that caveolae of human airway smooth muscle (ASM), which express caveolin-1, contain Ca2+ and force regulatory proteins and are involved in mediating the effects of inflammatory cytokines such as TNF-α on intracellular Ca2+ concentration responses to agonist. Accordingly, we tested th

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Tagawa, Akiko, Anna Mezzacasa, Arnold Hayer, Andrea Longatti, Lucas Pelkmans, and Ari Helenius. "Assembly and trafficking of caveolar domains in the cell." Journal of Cell Biology 170, no. 5 (2005): 769–79. http://dx.doi.org/10.1083/jcb.200506103.

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Using total internal reflection fluorescence microscopy (TIR-FM), fluorescence recovery after photobleaching (FRAP), and other light microscopy techniques, we analyzed the dynamics, the activation, and the assembly of caveolae labeled with fluorescently tagged caveolin-1 (Cav1). We found that when activated by simian virus 40 (SV40), a nonenveloped DNA virus that uses caveolae for cell entry, the fraction of mobile caveolae was dramatically enhanced both in the plasma membrane (PM) and in the caveosome, an intracellular organelle that functions as an intermediate station in caveolar endocytosi

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Gerstenberger, Wladimir, Michaela Wrage, Eeva Kettunen, et al. "Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases." Analytical Cellular Pathology 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/8651790.

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The expression of caveolin-1 (CAV1) in both tumor cell and cancer-associated fibroblasts (CAFs) has been found to correlate with tumor aggressiveness in different epithelial tumor entities, whereas less is known for caveolin-2 (CAV2). The aim of this study was to investigate the clinicopathological significance and prognostic value of stromal CAV1 and CAV2 expression in lung cancer. The expression of these two genes was investigated at protein level on a tissue microarray (TMA) consisting of 161 primary tumor samples. 50.7% of squamous cell lung cancer (SCC) tumors showed strong expression of

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Copeland, Courtney A., Bing Han, Ajit Tiwari, et al. "A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal." Molecular Biology of the Cell 28, no. 22 (2017): 3095–111. http://dx.doi.org/10.1091/mbc.e17-06-0421.

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Caveolin-1 (CAV1) is an essential component of caveolae and is implicated in numerous physiological processes. Recent studies have identified heterozygous mutations in the CAV1 gene in patients with pulmonary arterial hypertension (PAH), but the mechanisms by which these mutations impact caveolae assembly and contribute to disease remain unclear. To address this question, we examined the consequences of a familial PAH-associated frameshift mutation in CAV1, P158PfsX22, on caveolae assembly and function. We show that C-terminus of the CAV1 P158 protein contains a functional ER-retention signal

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Păunescu, Teodor G., Hua A. J. Lu, Leileata M. Russo, et al. "Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells." American Journal of Physiology-Renal Physiology 305, no. 12 (2013): F1783—F1795. http://dx.doi.org/10.1152/ajprenal.00622.2012.

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Caveolin (Cav)1 is expressed in the basolateral membrane domain of renal collecting duct (CD) principal cells (PCs), where it is associated with caveolae. To reveal any potential involvement of Cav1 in vasopressin signaling, we used specific monoclonal and polyclonal antibodies to examine its localization in CD PCs of Brattleboro (BB) rats treated with vasopressin (DDAVP). Compared with controls, immunofluorescence revealed a time-dependent increase in Cav1 expression in the apical membrane domain of PCs, where it overlapped with aquaporin-2 (AQP2). After 24 h of DDAVP treatment, Cav1 was visi

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Zimnicka, Adriana M., Yawer S. Husain, Ayesha N. Shajahan, et al. "Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae." Molecular Biology of the Cell 27, no. 13 (2016): 2090–106. http://dx.doi.org/10.1091/mbc.e15-11-0756.

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Caveolin 1 (Cav1) is a required structural component of caveolae, and its phosphorylation by Src is associated with an increase in caveolae-mediated endocytosis. Here we demonstrate, using quantitative live-cell 4D, TIRF, and FRET imaging, that endocytosis and trafficking of caveolae are associated with a Cav1 Tyr-14 phosphorylation-dependent conformational change, which spatially separates, or loosens, Cav1 molecules within the oligomeric caveolar coat. When tracked by TIRF and spinning-disk microscopy, cells expressing phosphomimicking Cav1 (Y14D) mutant formed vesicles that were greater in

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Thèses sur le sujet "Caveoli-1 (Cav1)"

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Burgy, Mickaël. "Intérêt pronostic et thérapeutique de l'axe miR-30a/e-3p -Cav1 dans les carcinomes épidermoïdes de la tête et du cou." Electronic Thesis or Diss., Strasbourg, 2025. http://www.theses.fr/2025STRAJ002.

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Le pronostic péjoratif des carcinomes épidermoïdes de la tête et du cou (CETEC) tient en partie aux mécanismes encore non élucidés de résistances aux thérapies actuelles. De plus l’absence de biomarqueurs complique le développement de stratégies thérapeutiques reposant actuellement sur le stade de la maladie excluant les caractéristiques biologiques tumorales. Dans ce projet de recherche translationnelle, nous avons identifié la cavéoline-1 (Cav1) et les miR-30a/e-3p comme des biomarqueurs pronostiques de la survie et de la récidive tumorale. Nous avons validé l’implication de l’axe CAV1/EREG/

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Wong, Kevin L. "Caveolae and Caveolin-1 are important for Vitamin D signalling." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37086.

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The most active form of Vitamin D, 1alpha,25(OH)2D3, modulates cells via receptor mediated mechanisms. While studies have elucidated the pathway via the classical nuclear Vitamin D Receptor (VDR), little is known about the membrane-associated Vitamin D Receptor (ERp60). Caveolae and its characteristic protein Caveolin-1 have been involved in many signaling pathways due to its specific structure and physical configuration. Other studies have shown that many components of the Vitamin D pathway have been found in caveolae. This study hypothesizes that caveolae and Caveolin-1 are important for the

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Zampier, Carolina da Paz. "Papel de caveolina-1 na produção de mediadores inflamatórios." Instituto Oswaldo Cruz, 2012. https://www.arca.fiocruz.br/handle/icict/7031.

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Submitted by Alessandra Portugal (alessandradf@ioc.fiocruz.br) on 2013-10-01T21:53:22Z No. of bitstreams: 1 Carolina da Paz Zampier.pdf: 2134379 bytes, checksum: d822f378a88e2cf44b02c5ea60f52ea0 (MD5)<br>Made available in DSpace on 2013-10-01T21:53:22Z (GMT). No. of bitstreams: 1 Carolina da Paz Zampier.pdf: 2134379 bytes, checksum: d822f378a88e2cf44b02c5ea60f52ea0 (MD5) Previous issue date: 2012<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>A caveolina-1 (Cav-1), uma proteína essencial para a formação de cavéolas, apresenta atividade na modulação da sinali

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Comajoan, von Arend Pau. "Efecte de l'administració de l'rt-PA en condicions isquèmiques in vitro i in vivo: Cav-1 com a potencial biomarcador de volum d'infart." Doctoral thesis, Universitat de Girona, 2019. http://hdl.handle.net/10803/669184.

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Recombinant tissue plasminogen activator (rt-PA) is currently the only FDA-approved drug for the treatment of acute ischaemic stroke. However, the application of this therapy is limited to <5-7% of patients due to the associated increased risk of haemorrhagic transformation (HT). Although it is known that HT is related to rt-PA-induced blood brain barrier (BBB) disruption, the underlying mechanisms are not well established. The obtained results show that long-term studies are needed to elucidate time-dependent molecular mechanisms associated to BBB breakdown, and to explore protective BBB ther

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Jehl, Aude. "Cavéoline-1 prédictive de la métastase et de la rechute locorégionale des cancers des voies aérodigestives supérieures." Thesis, Strasbourg, 2022. http://www.theses.fr/2022STRAJ070.

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Ce projet de recherche translationnelle sur les cancers des voies aérodigestives supérieures (VADS) a permis d’identifier la cavéoline-1 (Cav1) comme un biomarqueur pronostique de l’évolution d’une tumeur primitive des VADS. En effet, une surexpression de cette protéine favorise une rechute locorégionale alors qu’un déficit de Cav1 engage la tumeur vers un processus métastatique. De plus, nous avons mis en évidence l’implication de l’axe Cav1 / EREG / YAP dans la résistance au traitement (cétuximab et radiothérapie). Enfin, nous avons identifié l’épireguline (EREG) comme la protéine clé de la

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Chapitres de livres sur le sujet "Caveoli-1 (Cav1)"

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Hadinnapola, Charaka, and Nicholas Morrell. "Heritable pulmonary arterial hypertension." In ESC CardioMed, edited by Marc Humbert. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0590.

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Heritable pulmonary arterial hypertension (PAH) is diagnosed in patients presenting with PAH who have a family history of the disease or carry a mutation in a gene known to be associated with PAH. Heterozygous mutations in the gene encoding the bone morphogenetic protein receptor type 2 (BMPR2) are the most common genetic defects seen in heritable PAH. Mutations in BMPR2 are found in 82% of patients with a family history of PAH and 17% of patients presenting with no family history of the disease. Other causal genes include members of the transforming growth factor beta pathway, including activing receptor-like kinase 1 (ACVRL1) and endoglin (ENG), as well as caveolin 1 (CAV1) and the potassium two-pore domain channel subfamily K member 3 (KCNK3).

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Actes de conférences sur le sujet "Caveoli-1 (Cav1)"

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Hynes, TS, S. Basu, AJ Halayko, and R. Mitchell. "Caveolin-1 (Cav-1) Orchestrates Allergic Airways Inflammation & Hyperresponsiveness in a Mouse Model of Allergic Asthma." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2421.

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Mitchell, RW, Y. Bai, T. Hynes, S. Basu, MJ Sanderson та AJ Halayko. "Airway Smooth Muscle (ASM) from Caveolin-1 Knockout (Cav-1 KO) Mice Exhibits Gs-Coupled β2-Receptor Hyperresponsiveness In Vitro." У American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2052.

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Yamaguchi, Tomoya, Can Lu, Lisa Ida, et al. "Abstract 4585: ROR1 sustains caveolae and RTK-mediated survival signaling as a scaffold of cavin-1 and CAV1 in lung cancer." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4585.

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Nho, Richard, and Polla Hergert. "Caveolin-1 (Cav-1) Alteration By Aberrant Forkhead Box O3a (FoxO3a) Activity Confers A Highly Proliferative And An Anti-Apoptotic IPF Fibroblast Phenotypes On Type I Collagen Matrix." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3497.

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Rapports d'organisations sur le sujet "Caveoli-1 (Cav1)"

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Chanvorachote, Pithi. Roles of nitric oxide, reactive oxygen species, and their derivatives in regulation of lung cancer cell metastasis. Chulalongkorn University, 2013. https://doi.org/10.58837/chula.res.2013.28.

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The capability of cancer cells to resist to anoikis, migrate and invade surrounding tissues is associated with high metastatic potential and advanced stage of cancers. Recently, caveolin-1 (Cav-1) protein has garnered increased attention in implicating the aggressive behavior of cancer cells. We demonstrate herein that nitric oxide and hydrogen peroxide play a role in inhibiting anoikis process of lung cancer cells via caveolin-1 dependent mechanism. The Cav-1 function in inhibition of anoikis was demonstrated to be cause through Mcl-1 dependent mechanism. The present study demonstrated that C

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