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Articles de revues sur le sujet « Cd40lg- »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 19 juillet 2025

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1

Hubbard, Nicholas, David Hagin, Karen Sommer, et al. "Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome." Blood 127, no. 21 (2016): 2513–22. http://dx.doi.org/10.1182/blood-2015-11-683235.

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Key PointsThe CD40LG locus can be specifically targeted and repaired in primary human T cells by insertion of a spliced CD40LG complementary DNA. Gene editing restores regulated CD40L expression in X-HIGM T cells, reconstituting B-cell immunoglobulin class switching.

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Hubbard, Nicholas Wesley, David Hagin, Karen Sommer, et al. "Targeted Gene Editing Restores Regulated CD40L Expression and Function in X-HIGM T cells." Journal of Immunology 196, no. 1_Supplement (2016): 214.28. http://dx.doi.org/10.4049/jimmunol.196.supp.214.28.

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Abstract Loss of CD40L expression or function results in X-Linked Hyper-IgM Syndrome (X-HIGM), characterized by recurrent infections due to impaired immunoglobulin class-switching and somatic hypermutation. Previous attempts using retroviral gene transfer to correct murine CD40L expression restored immune function; however, treated mice developed lymphoproliferative disease, likely due to viral-promoter dependent constitutive CD40L expression. These observations highlight the importance of preserving endogenous gene regulation in order to safely correct this disorder. Here we report efficient,

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Kutukculer, Necil, Neslihan Edeer Karaca, Guzide Aksu, Ayca Aykut, Erhan Pariltay, and Ozgur Cogulu. "An X-Linked Hyper-IgM Patient Followed Successfully for 23 Years without Hematopoietic Stem Cell Transplantation." Case Reports in Immunology 2018 (October 14, 2018): 1–4. http://dx.doi.org/10.1155/2018/6897935.

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When caring for patients with life-limiting diseases, improving survival and optimizing quality of life are the primary goals. For patients with X-linked hyper-IgM syndrome (XHIGM), the treatment modality has to be decided for a particular patient regarding hematopoietic stem cell transplantation or intravenous immunoglobulin replacement therapy with P. jiroveci prophylaxis. A seven-year-old male patient was admitted with recurrent upper and lower respiratory tract infections and recurrent otitis media. His initial immunologic evaluation revealed low IgG and normal IgA and IgM levels with norm

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Kato, Kazunori, Yukari Masuta, Kei Tomihara, Katsunori Sasaki, and Hirofumi Hamada. "A Novel Non-Cleavable Cell Surface Mutant of CD40-Ligand Induces Anti-Leukemic Immune Response and Prevent Systemic Inflammatory Reaction." Blood 104, no. 11 (2004): 3174. http://dx.doi.org/10.1182/blood.v104.11.3174.3174.

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Abstract CD40-ligand (CD40L), a member of the TNF family, is expressed transiently on activated CD4-positive T cells and mediates cognate interaction between T cell and antigen-presenting cell (APC) such as dendritic cells. We and other investigators have reported previously that transduction of human leukemia cells with adenovirus encoding full-length CD40-ligand resulted in upregulation of immune costimulatory molecules, enhance APC activity and generation of CTL to leukemia B cells. However, CD40L is cleaved to a soluble form (sCD40L) by metalloproteases and high levels of sCD40L may contri

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Yeh, Yu-Min, Peng-Chan Lin, Wu-Chou Su, and Meng-Ru Shen. "CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c.1085 Genotypes." International Journal of Molecular Sciences 22, no. 22 (2021): 12565. http://dx.doi.org/10.3390/ijms222212565.

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Colony-stimulating factor 1 receptor (CSF-1R) acts as the receptor for colony stimulating factor 1, a cytokine that controls the production, differentiation, and function of macrophages. Prior studies showed cancer patients harboring germline CSF1R c.1085A>G genetic variant had better survival. Here, primary tumor samples from a stage III colorectal cancer (CRC) cohort were analyzed by a targeted gene expression assay containing 395 immune-related genes to study the immune mechanism underlying the different outcomes. CRC patients with CSF1R c.1085 genotype A_G had a better disease-free and

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Dong, Qiuting, Jinxia Zhao, Zhongqiang Yao, Xiangyuan Liu, and Huiying He. "A Case Report of X-Linked Hyperimmunoglobulin M Syndrome with Lipoma Arborescens of Knees." Case Reports in Medicine 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/5797232.

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The X-linked hyperimmunoglobulin M syndrome (HIGM), caused by mutations in the CD40LG gene, is a kind of primary immunodeficiency disease (PID). Patients with X-linked HIGM are susceptible to infection as well as autoimmune diseases. Lipoma arborescens (LA) is a rare benign tumor, of which the pathogenesis mechanism has not been clearly understood. We report a case of HIGM combined with LA in a 22-year-old male patient. A new deletion mutation of CD40LG gene was detected in this case. The possible relationship between HIGM and LA was also discussed.

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Rigaud, Stéphanie, Eduardo Lopez-Granados, Sophie Sibéril, et al. "Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG." Blood 118, no. 2 (2011): 252–61. http://dx.doi.org/10.1182/blood-2011-01-328849.

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Abstract The present study focuses on a large family with an X-linked immunodeficiency in which there are variable clinical and laboratory phenotypes, including recurrent viral and bacterial infections, hypogammaglobulinemia, Epstein-Barr virus–driven lymphoproliferation, splenomegaly, colitis, and liver disease. Molecular and genetic analyses revealed that affected males were carriers of a hypomorphic hemizygous mutation in XIAP (XIAPG466X) that cosegregated with a rare polymorphism in CD40LG (CD40 ligandG219R). These genes are involved in the X-linked lymphoproliferative syndrome 2 and the X

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Brune, Zarina, Bharati Matta, and Betsy Barnes. "IRF5 regulation of CD4+ T cell metabolism controls CD40L expression." Journal of Immunology 208, no. 1_Supplement (2022): 165.02. http://dx.doi.org/10.4049/jimmunol.208.supp.165.02.

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Abstract Systemic Lupus Erythematosus (SLE) is a devastating autoimmune disease that results from failure of the immune system to distinguish “self” from “non-self”. Studies in our lab and others demonstrated that human SLE CD4+ T cells have elevated levels of IRF5 and increased metabolism, while Irf5 knockout murine CD4+ T cells show diminished utilization of oxidative phosphorylation and glycolysis, respectively. However, how IRF5 contributes to CD4+ T cell support of B cell function and dysfunction has not been fully elucidated. Here, using IRF5 KO C57BL/6J mice, we show that loss of IRF5 i

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Horrillo, Angélica, Tomás Fontela, Elena G. Arias-Salgado, et al. "Generation of mice with conditional ablation of the Cd40lg gene: new insights on the role of CD40L." Transgenic Research 23, no. 1 (2013): 53–66. http://dx.doi.org/10.1007/s11248-013-9743-2.

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Shimoda, Michiko, Anna Bolduc, Mayuko Takezaki, Takeshi Tsubata, and Pandelakis Koni. "Excess B cell CD40/CD40L signaling promotes CD4 T cell-mediated encephalomyelitis in mice (44.22)." Journal of Immunology 186, no. 1_Supplement (2011): 44.22. http://dx.doi.org/10.4049/jimmunol.186.supp.44.22.

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Abstract To test the pathogenic role of B cells under excess inflammatory CD40/CD40L signaling, experimental autoimmune encephalomyelitis (EAE) was induced in B cell specific CD40L transgenic (CD40LBTg) and C57BL/6 control mice by immunization with MOG35-55 peptide. Clinical symptoms were monitored using a 0-5 scoring system during days 10-30 after induction. Alternatively, MOG-specific CD4 TCR Tg (2D2) mice were crossed onto a CD40LBTg background and the incidence of spontaneous encephalomyelitis monitored at 4-35 weeks of age. Both CD40LBTg and control mice developed EAE with similar kinetic

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Sivagami, S., R. Rathna, S. Nagavignesh, N. V. Ghone, and M. Sivanandham. "In silico binding analysis of human CD40 ligand mimetic molecule, 3-(dimethylamino)-1-phenyl-1-propanone hydrochloride (3-DPH), with CD40 receptor molecules of various mammalian species." Journal of Environmental Biology 42, no. 2 (2021): 186–91. http://dx.doi.org/10.22438/jeb/42/2/mrn-1440.

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Aim: To investigate the binding of human CD40 ligand (CD40L) mimetic molecule, 3-(dimethylamino)-1-phenyl-1-propanone hydrochloride (3-DPH), with CD40 receptor (CD40R) molecules of Homo sapiens, Cavia porcellus, Cricetulus griseus, Macaca mulatta, Mus musculus, Oryctolagus cuniculus, Papio anubis and Rattus norvegicus species using bioinformatics tool. Methodology: Three-dimensional structures of CD40Rs and CD40Ls for various mammalian species were generated using the published crystal structure of human CD40 receptor-ligand complex by homology modelling using SWISS-MODEL tool. Furthermore, hu

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López-Herrera, Gabriela, José Luis Maravillas-Montero, Alexander Vargas-Hernández, et al. "A novel CD40LG deletion causes the hyper-IgM syndrome with normal CD40L expression in a 6-month-old child." Immunologic Research 62, no. 1 (2015): 89–94. http://dx.doi.org/10.1007/s12026-015-8638-0.

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Menéndez, Méndez, Almansa, et al. "Simultaneous Depression of Immunological Synapse and Endothelial Injury is Associated with Organ Dysfunction in Community-Acquired Pneumonia." Journal of Clinical Medicine 8, no. 9 (2019): 1404. http://dx.doi.org/10.3390/jcm8091404.

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Rationale: A depressed expression of antigen presentation is, along with endothelial dysfunction, a recognized signature of severe community-acquired pneumonia (CAP). We aimed to evaluate the expression of a number of genes involved in the immunological synapse in non-critically ill CAP patients with or without organ dysfunction and to profile endothelial biomarkers such as proendothelin-1 (proET1) and proadrenomedullin (proADM). Methods: A nested study in a prospective cohort in CAP patients was performed. Expression levels of major histocompatibility complex class II DR alpha (HLA-DRA), CD40

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Li, Xuejing, Yungai Cheng, Dan Xu, et al. "A novel CD40LG mutation causing X‑linked hyper-IgM syndrome." Global Medical Genetics 12, no. 3 (2025): 100007. https://doi.org/10.1016/j.gmg.2024.100007.

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Román-Fernández, I. V., G. A. Sánchez-Zuno, J. R. Padilla-Gutiérrez, et al. "The 3′-UTR (CA)n microsatellite on CD40LG gene as a possible genetic marker for rheumatoid arthritis in Mexican population: impact on CD40LG mRNA expression." Clinical Rheumatology 37, no. 2 (2017): 345–53. http://dx.doi.org/10.1007/s10067-017-3853-9.

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Hong, Jian, Saber Y. Adam, Shiqi Wang, et al. "Melatonin Modulates ZAP70 and CD40 Transcripts via Histone Modifications in Canine Ileum Epithelial Cells." Veterinary Sciences 12, no. 2 (2025): 87. https://doi.org/10.3390/vetsci12020087.

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Melatonin (MLT), produced by the pineal gland and other tissues, is known for its anti-inflammatory effects, particularly in regulating inflammatory markers and cytokines in intestinal cells. Our study aimed to investigate how MLT influences the expression of inflammatory genes through histone modification in canine ileum epithelial cells (cIECs). In our experiment, cIECs were cultured and divided into a control group (CON) and an MLT-treatment group. MLT did not significantly affect cell growth or death in cIECs compared to the CON. However, MLT treatment led to an upregulation of CD40, ZAP70

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Pérez-Melgosa, Mercedes, Diane Hollenbaugh, and Christopher B. Wilson. "Cutting Edge: CD40 Ligand Is a Limiting Factor in the Humoral Response to T Cell-Dependent Antigens." Journal of Immunology 163, no. 3 (1999): 1123–27. http://dx.doi.org/10.4049/jimmunol.163.3.1123.

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Abstract CD40 ligand (CD40L) plays a crucial role in T cell-dependent B cell responses, but whether its abundance is a limiting factor in their development is unclear. This question was addressed in transgenic mice expressing the murine CD40L gene under the control of the IL-2-promoter (CD40Ltg+). The fraction of activated T cells from the CD40Ltg+ mice with detectable levels of surface CD40L was modestly greater (1.1- to 2-fold) than littermate controls and paralleled an ∼1.8-fold increase in CD40L mRNA abundance. In response to trinitrophenol (TNP)-keyhole limpet hemocyanin and tetanus/dipht

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Park, Heiyoung, Theo Heller, and Barbara Rehermann. "Transcriptome analysis reveals distinct immune response profiles in HBeAg+ and HBeAg− HBV infection and in HBV/HDV co-infection." Journal of Immunology 198, no. 1_Supplement (2017): 158.18. http://dx.doi.org/10.4049/jimmunol.198.supp.158.18.

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Abstract In chronic hepatitis B virus (HBV) infection, HBeAg positivity is associated with an increase in liver inflammation and progression to liver cirrhosis and cancer. Super-infection with hepatitis D virus (HDV) results in more severe liver disease. The causative factors are unknown. To understand the unique immunopathogenesis of HBeAg+ chronic HBV infection and chronic HBV/HDV co-infection, we performed a comparative transcriptome analysis using peripheral blood mononuclear cells of 12 HBV infected patients (6 HBeAg+ vs. 6 HBeAg−), 10 HBV/HDV co-infected patients, and 12 uninfected contr

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De Maio, Diego Javier Prado, Bitha Narayanan, James La Porta, Usha Ganapathi, Ping Xie, and Lori R. Covey. "Activation-dependent post-transcriptional regulation of CD40L mediates B cell development and survival in germinal centers." Journal of Immunology 206, no. 1_Supplement (2021): 63.03. http://dx.doi.org/10.4049/jimmunol.206.supp.63.03.

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Abstract We have described a posttranscriptional pathway of induced mRNA stability that occurs at late times of T cell activation and is engaged by the binding of a polypyrimidine tract-binding protein (PTBP1) complex to the 3′UTR of the CD40L transcript. We explored the in vivo role of this pathway by generating a mouse bearing a deletion of the CD40L stability element (termed CD40LΔ5) and found that Tfh cells harboring the stability defect expressed approximately 60% of WT CD40L. Importantly, this decrease in CD40L corresponded to a poorly elaborated germinal center (GC) response which inclu

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Li, Jiayun, Zhikai Wang, and Douglas T. Fearon. "CD40 signaling induces type I interferon and immune control in mouse pancreatic cancer lacking the CXCL12-coat." Journal of Immunology 204, no. 1_Supplement (2020): 241.37. http://dx.doi.org/10.4049/jimmunol.204.supp.241.37.

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Abstract Pancreatic ductal adenocarcinoma (PDA) has a low 5 year survival rate of 8.5% because of its late diagnosis and resistance to the existing therapies. Patients with PDA who are microsatellite stable do not respond to check point blockade immunotherapy due to impaired T cell infiltration, which is mediated by the CXCL12-coat on cancer cells (Wang Z, et al. bioRχiv). In mouse hepatic metastases established with PDA cells from the KPC model of PDA, Krt19-CRISPR/Cas9-edited tumors lacking the CXCL12-coat showed a type I interferon (IFN) response as well as T cell infiltration and activatio

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Hayashi, Tomoko, Savita P. Rao, Pascal R. Meylan, Richard S. Kornbluth, and Antonino Catanzaro. "Role of CD40 Ligand in Mycobacterium avium Infection." Infection and Immunity 67, no. 7 (1999): 3558–65. http://dx.doi.org/10.1128/iai.67.7.3558-3565.1999.

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ABSTRACT Mycobacterium avium is a common opportunistic pathogen in immunocompromised patients such as those infected with human immunodeficiency virus. Although M. avium is an intracellular organism replicating predominantly in macrophages, disseminated M. avium infection is seen in AIDS patients with CD4+ cell counts of <50 cells/μl, suggesting a possible involvement of a T cell-macrophage interaction for the elimination of M. avium. To determine whether CD40-CD40 ligand (CD40L) interactions play a role in M. aviuminfection, we studied the ability of CD40L to restrict M. avium replication

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Curinga, Gabrielle, Sarah Leach, Swati Singh, et al. "316. Successful Editing of the CD40LG Locus in Human Hematopoietic Stem Cells." Molecular Therapy 24 (May 2016): S127. http://dx.doi.org/10.1016/s1525-0016(16)33125-2.

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Le Coz, Carole, Melissa Trofa, Camille M. Syrett, et al. "CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation." Journal of Allergy and Clinical Immunology 141, no. 6 (2018): 2308–11. http://dx.doi.org/10.1016/j.jaci.2018.02.010.

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Kim, Hyung Young, Tae Min Um, and Hee Ju Park. "A Novel Mutation in CD40LG Gene Causing X-Linked Hyper IgM Syndrome." Indian Journal of Pediatrics 85, no. 9 (2017): 788–89. http://dx.doi.org/10.1007/s12098-017-2526-7.

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Imai, Kohsuke, Mitsunobu Shimadzu, Takeo Kubota, et al. "Female hyper IgM syndrome type 1 with a chromosomal translocation disrupting CD40LG." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1762, no. 3 (2006): 335–40. http://dx.doi.org/10.1016/j.bbadis.2005.10.003.

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Qian, Zuanhao, Zhenglei Zhang, and Yingying Wang. "T cell receptor signaling pathway and cytokine-cytokine receptor interaction affect the rehabilitation process after respiratory syncytial virus infection." PeerJ 7 (June 12, 2019): e7089. http://dx.doi.org/10.7717/peerj.7089.

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Background Respiratory syncytial virus (RSV) is the main cause of respiratory tract infection, which seriously threatens the health and life of children. This study is conducted to reveal the rehabilitation mechanisms of RSV infection. Methods E-MTAB-5195 dataset was downloaded from EBI ArrayExpress database, including 39 acute phase samples in the acute phase of infection and 21 samples in the recovery period. Using the limma package, differentially expressed RNAs (DE-RNAs) were analyzed. The significant modules were identified using WGCNA package, and the mRNAs in them were conducted with en

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Choudhry, Hani, Ashwag Albukhari, Mohammad Mobashir, and Wesam H. Abdulaal. "Study of APOBEC3B focused breast cancer pathways and the clinical relevance." Journal of Basic Science 1, no. 1 (2024): 1–12. https://doi.org/10.63454/jbs20000002.

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APOBEC3B is considered as an enzymatic source of mutation in case of breast cancer and Human T-Cell Leukemia Virus Type 1 and Bone Leiomyosarcoma are also associated with it. The major functions controlled or affected due to APOBEC3B are gene expression, mRNA editing such as C -> U conversion, and deoxycytidine deaminase activity. Here, the main goal of the study was to perform a systematic analysis of APOBEC3B associated genes and its functional impact in human breast cancer. For this purpose, the datasets have been utilized from the publicly available database such as GEO, OncoLnc, and TC

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Coit, Patrick, Lindsey B. De Lott, Bin Nan, Victor M. Elner, and Amr H. Sawalha. "DNA methylation analysis of the temporal artery microenvironment in giant cell arteritis." Annals of the Rheumatic Diseases 75, no. 6 (2015): 1196–202. http://dx.doi.org/10.1136/annrheumdis-2014-207116.

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ObjectiveTo investigate the inflammatory response in giant cell arteritis (GCA) by characterising the DNA methylation pattern within the temporal artery microenvironment.MethodsTwelve patients with non-equivocal histological evidence for GCA and 12 age-matched, sex-matched and ethnicity-matched controls with normal biopsies were studied. DNA was extracted from the affected portions of temporal artery tissue in patients with GCA and from histologically confirmed normal arteries in controls. Genome-wide DNA methylation status was evaluated using the Illumina Infinium HumanMethylation450 BeadChip

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Pazhanisamy, Amudha, Salomao Doria Jorge, Michael T. Zimmermann, et al. "Advanced computational analysis of CD40LG variants in atypical X-linked hyper-IgM syndrome." Clinical Immunology 253 (August 2023): 109692. http://dx.doi.org/10.1016/j.clim.2023.109692.

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Reckamp, Karen L., Jasmine A. McQuerry, Isa Mambetsariev, et al. "Co-stimulatory and co-inhibitory immune markers in solid tumors with MET alterations." Future Science OA 7, no. 2 (2021): FSO662. http://dx.doi.org/10.2144/fsoa-2020-0159.

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The implication of MET alterations in solid tumors and the immune microenvironment remains elusive. Formalin-fixed, paraffin-embedded samples of 21 patients with solid tumors harboring MET alterations were used for immunohistochemical staining. Extracted RNA was analyzed with the NanoString nCounter human PanCancer immune profiling panel (NanoString Technologies, Inc., WA, USA). Patients were diagnosed with lung (n = 10), breast (n = 5), genitourinary (n = 3) or colorectal cancer (n = 3). Eleven had a MET missense mutation, four had an exon 14 splice site mutation and six had MET amplification

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Lu, Qianjin, Ailing Wu, Laura Tesmer, Donna Ray, Neda Yousif, and Bruce Richardson. "Demethylation of CD40LG on the Inactive X in T Cells from Women with Lupus." Journal of Immunology 179, no. 9 (2007): 6352–58. http://dx.doi.org/10.4049/jimmunol.179.9.6352.

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Trivellin, Giampaolo, and Constantine A. Stratakis. "CD40LG duplications in patients with X-LAG syndrome commonly undergo random X-chromosome inactivation." Journal of Allergy and Clinical Immunology 143, no. 4 (2019): 1659. http://dx.doi.org/10.1016/j.jaci.2018.12.1017.

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Gall, Tina, Hans Ochs, and M. Teresa de la Morena. "CD40LG genotype does not correlate with clinical phenotype in X-linked hyper-IgM syndrome." Clinical Immunology 250 (May 2023): 109462. http://dx.doi.org/10.1016/j.clim.2023.109462.

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McDyer, John F., Mark Dybul, Theresa J. Goletz, et al. "Differential Effects of CD40 Ligand/Trimer Stimulation on the Ability of Dendritic Cells to Replicate and Transmit HIV Infection: Evidence for CC-Chemokine-Dependent and -Independent Mechanisms." Journal of Immunology 162, no. 6 (1999): 3711–17. http://dx.doi.org/10.4049/jimmunol.162.6.3711.

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Abstract The role of exogenous stimulation of CD40 by CD40 ligand (CD40L) in dendritic cell (DC) maturation, CC-chemokine production, and CCR5 receptor expression was examined using a soluble trimeric CD40L agonist protein (CD40LT). Stimulation of monocyte-derived DCs with CD40LT enhanced the production of the CC-chemokines macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES and diminished surface expression of CCR5. Based on these findings, the functional role of CD40LT stimulation on the ability of DCs to replicate and transmit HIV viral infection was studied. The addition of CD40LT

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Kim, Jae Heon, Hee Jo Yang, Sung Sik Choi, Hong J. Lee, and Yun Seob Song. "Changes of proapoptotic and antiapoptotic genes affect sensitivity to apoptotic stimuli in impaired contractility due to long term bladder outlet obstruction." PLOS ONE 17, no. 12 (2022): e0279503. http://dx.doi.org/10.1371/journal.pone.0279503.

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Introduction The normal biological process that necessitates cell removal greatly depends on apoptosis. Long term bladder outlet obstruction (BOO) causes damaged smooth muscle cells to undergo apoptosis. However, smooth muscle cell apoptosis that BOO causes is not well known in impaired bladder contractility. Therefore, we designed this study to investigate whether long-term BOO could induce apoptosis activities and to obtain an expression profile of apoptosis related genes. Materials and methods We used 10 Sprague-Dawley six-week-old female rats. We separated them equally into two groups: a s

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Yuan, Manqiu, Jianying Pei, Ruihao Li, Lirong Tian, Xin He, and Yanping Li. "CD40LG as a Prognostic Molecular Marker Regulates Tumor Microenvironment Through Immune Process in Breast Cancer." International Journal of General Medicine Volume 14 (November 2021): 8833–46. http://dx.doi.org/10.2147/ijgm.s336813.

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Campos-Neto, Antonio, Pamela Ovendale, Teresa Bement, et al. "Cutting Edge: CD40 Ligand Is Not Essential for the Development of Cell-Mediated Immunity and Resistance to Mycobacterium tuberculosis." Journal of Immunology 160, no. 5 (1998): 2037–41. http://dx.doi.org/10.4049/jimmunol.160.5.2037.

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Abstract It has been proposed that the induction of cellular immunity and resistance to intracellular pathogens is dependent upon CD40 ligand (CD40L). In the present study we show that this proposal is not ubiquitously supported. Mice genetically deficient in CD40L (CD40LKO) were resistant to i.v. infection with Mycobacterium tuberculosis when assessed by survival and bacteriologic burden in the spleen, liver, and lungs. Infected CD40LKO mice developed granulomas that lacked epithelioid cells and were less numerous and markedly smaller than those observed in control mice. Upon stimulation with

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Apoil, P. A., E. Kuhlein, A. Robert, H. Rubie, and A. Blancher. "HIGM syndrome caused by insertion of an AluYb8 element in exon 1 of the CD40LG gene." Immunogenetics 59, no. 1 (2006): 17–23. http://dx.doi.org/10.1007/s00251-006-0175-5.

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Shimoda, Michiko, Anna Bolduc, Domonica Powell, et al. "A critical role of dendritic cells in CD8 T cell IL-10 expression during inflammatory response triggered by CD40-activated B cells (159.16)." Journal of Immunology 188, no. 1_Supplement (2012): 159.16. http://dx.doi.org/10.4049/jimmunol.188.supp.159.16.

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Abstract CD40LBTg mice, expressing a CD40 ligand (CD40L) transgene on B cells, represent a model for human diseases where B cells aberrantly express CD40L or receive excess CD40/CD40L signaling under inflammatory conditions. Here, we show that B cells expressing transgenic CD40L are capable of priming CD8 T cells and generate strong antigen-specific cytotoxicity. Adoptively transferred SIINFEKL peptide-loaded B cells from CD40LBTg but not wild type mice were able to activate self-reactive OT-I CD8 T cells upon immunization with OVA plus alum and trigger diabetes in RIP-OVA mice by enhancing th

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Fujisawa, Manabu, Tran B. Nguyen, Yoshiaki Abe, et al. "Germinal Center B Cells Derived from TET2-Mutated Clonal Hematopoiesis Provide a Microenviromental Niche for Tumor Cells in Angioimmunoblastic T-Cell Lymphoma." Blood 138, Supplement 1 (2021): 445. http://dx.doi.org/10.1182/blood-2021-149983.

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Abstract Background Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2mutations, whereas the G17V RHOA mutation in TET2-mutated immature cells facilitates development of T follicular helper (T FH)-like tumor cells. Notably, we and others have reported that immune cells derived from ACH with TET2 mutations infiltrate AITL tissues. However, how ACH-derived immune cells function as a microenvironmental niche in AITL remains largely unknown. Objective To elucidate the role of TET2-mutated immune cells in AITL tumorigenesis. Met

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Nimri, S., D. Atkinson, and S. Stutes. "M199 X- LINKED HYPER-IGM SYNDROME WITH CD40LG MUTATION IN A FEMALE PATIENT AND HER MALE SIBLING." Annals of Allergy, Asthma & Immunology 127, no. 5 (2021): S108. http://dx.doi.org/10.1016/j.anai.2021.08.340.

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Chen, Yixiang, Chloé Peubez, Sandrine Jayne, Gabriella Kocsis-Fodor, Martin J. S. Dyer, and Salvador Macip. "Differential activation of pro-survival pathways in response to CD40LG/IL4 stimulation in chronic lymphocytic leukaemia cells." British Journal of Haematology 184, no. 5 (2018): 867–69. http://dx.doi.org/10.1111/bjh.15197.

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Tsai, Hu-Yuan, Hsin-Hui Yu, Yin-Hsiu Chien, et al. "X-linked hyper-IgM syndrome with CD40LG mutation: Two case reports and literature review in Taiwanese patients." Journal of Microbiology, Immunology and Infection 48, no. 1 (2015): 113–18. http://dx.doi.org/10.1016/j.jmii.2012.07.004.

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Zhang, Hui, Fanbing Meng, Jinxuan Tang, et al. "Lactate inhibits T-cell activation in sepsis through CD40LG downregulation and SOCS3-mediated JAK1/STAT3 pathway suppression." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1871, no. 7 (2025): 167923. https://doi.org/10.1016/j.bbadis.2025.167923.

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Leal-Calvo, Thyago, Charlotte Avanzi, Mayara Abud Mendes, et al. "A new paradigm for leprosy diagnosis based on host gene expression." PLOS Pathogens 17, no. 10 (2021): e1009972. http://dx.doi.org/10.1371/journal.ppat.1009972.

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Transcriptional profiling is a powerful tool to investigate and detect human diseases. In this study, we used bulk RNA-sequencing (RNA-Seq) to compare the transcriptomes in skin lesions of leprosy patients or controls affected by other dermal conditions such as granuloma annulare, a confounder for paucibacillary leprosy. We identified five genes capable of accurately distinguishing multibacillary and paucibacillary leprosy from other skin conditions. Indoleamine 2,3-dioxygenase 1 (IDO1) expression alone was highly discriminatory, followed by TLR10, BLK, CD38, and SLAMF7, whereas the HS3ST2 and

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Wang, Yingying, Yu Xu, Qingquan Hua, et al. "Novel Prognostic Model Based on Immune Signature for Head and Neck Squamous Cell Carcinoma." BioMed Research International 2020 (October 19, 2020): 1–9. http://dx.doi.org/10.1155/2020/4725314.

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Background. Deciphering the immune characteristics within tumors and identifying the immune signals related to the prognostic factor are helpful for the treatment and management of tumor patients. However, systematic analysis of immune signatures in head and neck squamous cell carcinoma (HNSCC) remains largely unstudied. Methods. A total of 718 immune-related genes were extracted from RNA sequencing data from 519 HNSCC patients in the TCGA database, and survival analysis with integrated bioinformatics analyses was performed to build the final predictive prognosis model. Results. The 178 surviv

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Sun, Liping, Dandan Wang, Yan Xu, Wenxiu Qi, and Yanbo Wang. "Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example." Evidence-Based Complementary and Alternative Medicine 2020 (November 28, 2020): 1–23. http://dx.doi.org/10.1155/2020/8873371.

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Pneumonia is a serious global health problem and the leading cause of mortality in children. Antibiotics are the main treatment for bacterial pneumonia, but there are serious drug resistance problems. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and has a unique theory. This article takes the treatment of pneumonia with Ephedra sinica as a representative hot medicine and Scutellariae Radix as a representative cold medicine as an example. We explore and explain the theory of treating the same disease with different TCM treatments. Using transcriptomi

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Tsuchiya, Yukako, Taku Naito, Mari Tenno, et al. "ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells." Journal of Leukocyte Biology 100, no. 2 (2016): 327–38. http://dx.doi.org/10.1189/jlb.1a0915-396rr.

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Lin, S. C., and J. Stavnezer. "Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter." Molecular and Cellular Biology 16, no. 9 (1996): 4591–603. http://dx.doi.org/10.1128/mcb.16.9.4591.

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Interaction between CD40 on B cells and CD40 ligand (CD40L) on T cells has been shown to mediate T-cell contact help for B-cell proliferation, differentiation, and immunoglobulin isotype switching. It has recently been shown that cross-linking CD40 on mouse B cells induces germ line gamma1 and epsilon transcripts and that interleukin-4 synergizes with CD40 signaling to further induce these germ line transcripts. Germ line transcripts have been shown to be required for class switch recombination. Here we show that signaling via CD40 increases expression of a transiently transfected luciferase r

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Zhou, Ying, Jun Yuan, Yujun Pan, et al. "T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus." Clinical Immunology 132, no. 3 (2009): 362–70. http://dx.doi.org/10.1016/j.clim.2009.05.011.

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