Articles de revues sur le sujet « Cha yi »

<p>創傷性腦損傷的照護需要多科別及跨部門成員共同合作，方能打破各單位本位主義，凝聚共同目標及向心力，設定一致的照護流程及建立品質指標。品質指標可以檢視照護品質不足之處，團隊經由不斷滾動式的修正，終將指標轉為自動化收集；並導入資訊及多元創新通訊技術，首創建置IMPACT Outcome Score系統，評估創傷性腦損傷病人預後及死亡率，有利醫師進行病情說明，降低不必要的醫療行為，亦榮獲醫策會2020年國家醫療品質獎「智慧解決方案組-特別獎-潛力獎」。</p> <p>&nbsp;</p><p>Care for traumatic brain injury requires multidisciplinary and interdepartmental cooperation to remove the sectionalism of each unit, congregate common goals and cohesion, and establish consistent care procedures and quality indicators, which can be used to assess the quality of care and identify inadequacies. Through constant rolling adjustment, the indicators were eventually converted for automatic collection. Additionally, information and diverse innovative communications technologies were introduced to invent an IMPACT Outcome Score system to assess the prognosis and mortality of patients with traumatic brain injury. The system helps physicians in explaining the disease condition to the patients and avoids unnecessary medical behavior. The system won &quot;Smart Solution Group-Special Award for Potential&quot; of 2020 National Healthcare Quality Award by Joint Commission of Taiwan.</p> <p>&nbsp;</p>

Abstract A set of bronze parts, excavated in a funeral pit next to the tomb of Marquis Yi of Zeng (Hubei, China), is recently restored to its rightful shape, a hip-roof tent from the fifth century BCE. Measured 10m long and built with 127 wooden poles and 338 bronze parts, it is considered to be the largest and the most complicated tent in pre-imperial China, which is portable, easy to assemble, disassemble, and manufactured in an engineering design context.

Purpose: To examine the factorial structure of the Coping Strategy Questionnaire-24 (CSQ-24) in a sample of Canadians with chronic musculoskeletal pain.Method: The sample included 171 workers’ compensation clients (50.9% men) recruited from outpatient rehabilitation facilities in Canada. Mean age of participants was 42.45 years (SD = 9.87). Confirmatory factor analysis (CFA) was used to evaluate the factorial validity of the CSQ-24.Results: CFA indicated that the respecified 4-factor model comprising 20-specific coping items provided the best fit between the model and data, with χ2/df = 2.009, CFI = 0.916, RMSEA = .077. The Cronbach’s alpha coefficients for the 4 factors ranged from .80 to .86. The CSQ-24 correlated moderately in the predicted directions with pain intensity, activity interference, and depression, supporting its construct validity.Conclusion: The CSQ-24 was found to measure the 4 coping strategy factors reported by Harland and Georgieff (2003). It demonstrated good internal consistency reliability and construct validity and can be used as a brief coping measure for chronic pain clients in clinical rehabilitation settings.Chung-Yi Chiu, PhD, CRC, is an assistant professor, Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign.

The purpose of the research is to establish the humidity regime of sod-podzolic soil when growing perennial grasses. Experiments were conducted at the experimental site in 2012-2014. When conducting scientific research on the water regime of sod-podzolic soils for irrigation of perennial grasses, the method developed at the department of land reclamation and recultivation of the Russian state agrarian University-Moscow state agricultural Academy named after C.A. Timiryazev was used. Studies were conducted on experimental plots and in lysimeters. Experimental data obtained on plots are presented. Based on the results of research, using the formula of V.V. Shabanov,a graph of the relationship between the relative yield (Yi /Ymax) of perennial grasses and the relative humidity of sod-podzolic soil (in a layer of 50 cm) during sprinkling was constructed. In the formula of V.V. Shabanov for the conditions under consideration, the value of the coefficient Yi was obtained equal to 4.263. It was found that the humidity of the sod-podzolic soil of watershed territories. must be maintained in the optimal range taking into account the requirements of plants during the entire vegetation period. The best range of humidity of sod-podzolic soil of watershed territories according to scientific research data is for perennial grasses (0.61-0.78) PV. The correlation coefficient of this relationship is 0.96 ± 0.089 which indicates a close relationship between the considered features. At optimal humidity of sod-podzolic soils (0.61-0.78) of PV and a groundwater depth of 1.60 m or deeper (the territory of watersheds) there is a leaching regime.

This paper mainly analyzes the feasibility of laparoscopic local gastrectomy for the treatment of benign gastric tumors, evaluating its curative effect, and the use of traditional Chinese medicine (TCM) such as Hedyotis diffusa, Radix Pseudostellariae, yi, Pinellia ternata, Ophiopogon japonicus, wood fragrance, Perilla, Scutellaria baicalensis, Yuzhu, hawthorn, Artemisia annua, chicken yellow film, nail, and turtle, and clinical symptoms of statistical analysis of data mining. A total of 86 patients with gastric benign tumor were selected as the research object and were divided into observation group and control group with 43 cases in each by the random number table method. The control group received radical gastrectomy for benign tumor under laparoscopy, while the observation group received local gastrectomy under laparoscopy. Perioperative indexes such as operative time, intraoperative blood loss, and length of hospital stay were recorded in the two groups. Serum C-reactive protein (CRP) and carcinoembryonic antigen (CEA) levels were analyzed by enzyme-linked immunosorbent assay (ELISA), and the incidence of complications was compared. Based on the clinical analysis of the drug used, the results of association significance were selected, and the top ten results were selected in order of confidence and grouped according to clinical symptoms, respectively, as follows: (1) abdominal distension: Hedyotis diffusa, Radix Pseudostellariae, Poria cocos, Huckleberry, and Coix seed; (2) dry mouth: Poria cocos, Radix Radix Pseudostellariae, Coix seed, Pinellia tuber, and Radix Ophiopogonis. The results showed that the minimum operation time in the observation group was 159.7 ± 13.07 min and the maximum was 172.57 ± 2.47 min, which was lower than that in the control group (the minimum was 172.46 ± 12.45 min and the maximum was 186.49 ± 24.32 min). The length of hospital stay (6.51 ± 1.29 days) was lower than that in the control group (7.56 ± 1.42 days) (P < 0.05). The CEA and CRP levels decreased significantly in both groups after treatment ( P < 0.05 ). However, the observation group’s CEA was (4.21 ± 1.05) mg/L and CRP was (8.46 ± 1.25) μg/L. In the control group, CEA was (4.18 ± 1.02) mg/L and CRP was (8.39 ± 1.24) μg/L. There were no significant differences ( P < 0.05 ). The incidence of complications in the observed group was 4.7% lower than 7.0% in the control group ( P < 0.05 ). Therefore, laparoscopic local gastric resection for benign gastric tumors can effectively reduce the incidence of CEA and CRP level and complications and improve the perioperative indicators, which is worth popularizing in clinical practice.

Nhwehwɛmu da no adi sɛ, ɛnnɛ yi nso, wɔde mmɛ di dwuma pa ara wɔ Akan radio ne TV so dwumadie ahodoɔ no mu, titire ne anɔpa dawubɔ nkrataa mpɛnsɛmpɛnsɛnmu ne kaseɛbɔ. Ɛso akasafoɔ dodoɔ no taa yɛ amanyɔfoɔ ne amanyɔkuo akyitaafoɔ. Dwumadie yi mu nsɛm nso taa fa asetena-amanyɔ ho. Nsɛm no bi ka yɛ den; ɛtumi dane abufuo anaa ɛde ɔtan ba. Ɛno na ama yɛahwɛ sɛdeɛ wɔde mmɛ di dwuma wɔ dwumadie no mu. Yɛhwɛɛ mmɛ pɔtee a wɔtaa fa no mu nsɛm ne botaeɛ nti a wɔfa saa mmɛ no. Yɛahwɛ mmɛ no nhyehyɛeɛ ne ne sohyiɔ-pragmatek dwumadie. Yɛgyee mmɛ no ne ɛho nsɛm kakra firii Peace F.M.; Kookrokoo ne Adom F.M.; Edwaso Nsɛm, UTV ne Adom TV. Yɛhwɛɛ berɛ ne nnipa pɔtee a nsɛm no fa wɔn ho. Anɔpa dawubɔ nkrataa mpɛnsɛmpɛnsɛnmu taa wɔ anɔpa firi nnɔnsia kɔpem nnɔndu. Wei nso boa maa yɛhunuu botaeɛ pɔtee a ɛma akasafoɔ no de saa mmɛ pɔtee no di dwuma. Yɛgyinaa Fairclough (1995 ne 2012) ne Fairclough ne Wodak (1997) adwenemusɛm CDA so na ɛyɛɛ mpɛnsɛmpɛnsɛnmu no. Ɛdaa adi sɛ, mmɛ a amanyɔfoɔ taa de di dwuma no gu mmusuakuo mmeɛnsa; mmɛ dada, nsesamu anaa mframu ne abɛɛfo mmɛ. Nsesamu no nso nhyehyɛeɛ gu; nsɛmfua nsiananmu ne nyifirimu. Yɛhunuu sɛ, sɛdeɛ kaseɛbɔfoɔ nwene wɔn ankasa mmɛ no, amanyɔfoɔ ntaa nnwene mmɛ foforɔ. Sohyiɔ-pragmateks dwumadiemu nso, ɛbɛdaa adi sɛ, wɔmfa mmɛ no nni dwuma sɛ kwatikwan turodoo nko, wɔde bi yɛ sabuakwan (anidaho). The morpho-syntactic and socio-pragmatic analysis of proverbs use on radio and T.V.: “Traditional priests of doom, if you wish for the destruction of a town, …” Agyekum (2000) and Wiafe-Akenten (2015) have observed an extensive use of proverbs in the media since the establishment of Ghana Broadcasting Corporation (GBC) in 1954. This paper therefore examines how these proverbs are used in radio and television programmes, especially in the Morning Shows and News broadcast in Akan. These programmes are socio-political, in which some of the issues discussed are very sensitive, delicate and inflammatory. The paper focuses on investigating how participants of these programmes employ proverbs in handling such difficult issues in their interactions, especially within this highly formal setting. Data for this study was sourced from Peace F.M., Adom F.M, GTV, UTV, (all in the Greater Accra Region of Ghana) Kessben F.M. (in the Ashanti Region of Ghana) and Ɔboɔba F.M. (in the Eastern Region of Ghana). Recordings of 6:00a.m, 12 noon and 6:00p.m. News from the radio stations and Television stations, and those of the Morning Shows from 6am-10am constituted the data for the study. Also, follow-up interviews were conducted after the recordings were transcribed for further analysis. The text and their context were discussed using Fairclough’s (1995 and 2012) and Fairclough & Wodak’s (1997) approach to Critical Discourse Analysis (CDA). The study specifically looked at the structural and lexical content of the proverbs, the motivation behind choice of certain proverbs and socio-pragmatic functions of the selected proverbs. Findings from the study showed that, some presenters and hosts of the programmes utilized proverbs as facesaving, mitigating and softening strategies. It was also concluded that majority of the politicians also employed the proverbs as indirectional strategies, escape routes, and evasive tools. They either removed or added their own words to strategically manipulate the proverbs to carry out and/or suit their intended message.

Abstract Background: The carcinoembryonic antigen-related adhesion molecules (CEACAM), containing seven members, are involved in many biological processes including cell adhesion, proliferation, differentiation, and tumor suppression. Some variants of CEACAMs such as CEACAM5 and CEACAM6 have long been recognized to be overexpressed in many cancers and highly associated with cancer development. Immunotherapies targeting CEACAM have achieved some clinical benefit, e.g. Tusamitamab Ravtansine (anti-CEACAM5 ADC), that has shown decent disease control in NSCLC. Recently, with the success of CAR-T and T cell engager (TCE) therapies against blood cancers, TCEs against solid tumors have also been developed. For instance, Cibisatamab, targeting CEACAM5 and CD3, is currently under clinical investigation in CRC patients. Here, we report the discovery of a bispecific antibody (biAb) anti-CEACAM5/6 x CD3 that mediates direct T cell killing against CEACAM5- and/or CEACAM6-expressing cancer cells. Methods: Anti-CEACAM5/6 x CD3 TCE consists of two CEACAM5/6 binding Fabs for the preferential recognition of CEACAM5/6-high-expressing cancer cells, and one CD3 binding domain that permits CEACAM5/6-mediated CD3 crosslinking and T cell activation. To reduce off-target T cell stimulation there is no CH2 in this format to eliminate Fc receptor binding, while an anti-HSA VHH was included into this construct for half-life extension. Binding affinity and specificity were studied by flow cytometry, IHC and on the Retrogenix Cell Microarray Technology platform, a human membrane/secreted protein binding array. The immunomodulatory functions were evaluated using luciferase reporter cell assays, cell killing assays in vitro and via PBMC-based Hu-NSG mouse models in vivo. Results: Our CEACAM5/6 binding antibody only interacted with CEACAM5 and CEACAM6 on the Retrogenix Cell Microarray against over 5,500 proteins. Importantly, it showed a similar sensitivity to recognize CRC tumor tissues in an IHC array as the benchmark (BMK), but significantly better selectivity at recognition of tumor tissues vs. normal tissues. Next, in vitro testing illustrated CEACAM5/6-mediated T cell activation by the TCE, and such stimulation also correlated with the binding affinity of the anti-CD3 domain. The lead candidate with the optimized CD3 binding affinity, showed better anti-tumor efficacy than the BMK in mice. Furthermore, this molecule displayed a typical PK as a conventional antibody with a mean T1/2 of around 115hrs. Finally, we show high tolerance in NHP of which no obvious signs of toxicity were observed at 2.5 mg/kg. Conclusion: In summary, a bispecific TCE with high selectivity to CEACAM5/6 overexpressing cancer cells was engineered. It displays potent anti-tumor efficacy, and support from target selectivity testing shows promising safety traits. Citation Format: Liandi Chen, Weifeng Huang, Xiaoniu Miao, Jiayi Si, Chao Wang, Tiantian Dong, Andy Tsun, Yi Luo. A bispecific T cell engager targeting CEACAM5/6 exhibits strong anti-tumor efficacy in pre-clinical studies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5554.

Listado Póster Déficit de vitamina B12 en pacientes con uso crónico de metformina. Prevalencia y factores asociados. Alvarez M, Rincón O. Póster Síndrome glucagonoma: reporte de un caso. Álvarez M, Almánzar A, Sanabria F, Zárate L, Meneses G, Velásquez L. Póster Factores de riesgo asociados a la presencia de hipoglucemia en los pacientes sometidos a cirugía cardiovascular en el Hospital Universitario San Ignacio. Gómez AM, Pérez-Cely JA, Muñoz-Velandia OM, Fuentes-Castillo OE , Rendón-García NA, Sanko- Posada AA, Robledo-Gómez MA. Póster Subestimación de la prevalencia de diabetes mellitus tipo 2 en el Caribe colombiano. ¿La “regla de las dos mitades” en diabetes mellitus es aún válida? Miranda Machado P., Salcedo Mejía F., Alvis Guzmán N., De la Hoz Restrepo F. Póster Caracterización de pacientes de 6-16 años con riesgo de obesidad y sobrepeso en una consulta de endocrinología pediátrica en la ciudad de Cali, Colombia. Mirey Siuffi Póster Alteración de conductas alimentarias asociadas con obesidad y parámetros bioquímicos en estudiantes universitarios. Guzmán Flores JM, Ramírez De los Santos S, López Pulido EI, Gonzáles Sánchez GD, Castellanos Gallegos LG, Barajas Pérez LP, Becerra Hurtado J, Rivas Delgado ME. Póster Espectro clínico y radiológico del síndrome de corea-balismo asociado a hiperglucemia: Revisión sistemática y metanálisis. Gómez Ochoa SA, Espín Chico BB, Téllez Mosquera LE. Póster Hormona luteinizante, obesidad y alteraciones bioquímicas y hormonales en el síndrome de ovario poliquístico. Cruz J, García L, Cabrera M, Monteagudo G, Yanes M, González T. Póster Uso de la tasa metabólica en reposo en la consulta externa de endocrinología en Colombia. Rosero O, F. Póster Factores pronósticos de evolución en la cetoacidosis diabética. González TM, Cruz J, Conesa AI Póster Prevalencia y resultados del embarazo de diabetes gestacional en Cuba, 2008-2016. Cruz J, Lang J, Hernández P, Conesa AI, Padilla L, Márquez A. Póster Complicaciones vasculares y neuropáticas en la prediabetes. Conesa AI, González TM, Cruz J. Póster Factores de riesgo cardiovascular y su relación con los niveles séricos de lecitín colesterol acil transferasa en mujeres posmenopáusicas. Rebolledo Cobos R, Becerra Enríquez J, Suárez Rodríguez A y Sarmiento Rubiano L. Póster Atención preconcepcional y resultados del embarazo de diabetes pregestacional en Cuba, 2008-2016. Cruz J, Lang J, Hernández P, Conesa AI, Iglesias I, Márquez A. Póster El consumo del agraz colombiano vaccinium meridionale Swartz tiene un efecto positivo en marcadores del síndrome metabólico en mujeres sin dislipidemia aterogénica. Espinosa J, Marín C, Galvis Y, Aristizábal JC, Núñez V, Ciro G, Barona J. Póster Niveles saludables de fuerza muscular se asocian con menor riesgo cardiometabólico en universitarios con sobrepeso, pero no en sus contrapartes con obesidad moderada y/o severa. Ramírez Vélez R, Correa Bautista JE, García Hermoso A, Izquierdo M Póster Impacto del ejercicio de alto rendimiento y la ingesta calórica sobre la composición corporal y crecimiento en infantes. Jaramillo AM, Rosero RJ, Cossio I, Palacio JI. Póster Tasa metabólica basal en una población de mujeres con obesidad y/o sobrepeso que asisten a consulta de endocrinología en Villavicencio. Francisco Rosero O, Pantoja D. Póster Sobrepeso, obesidad y resistencia a la insulina en un grupo de mujeres posmenopáusicas del Departamento del atlántico. Sarmiento-Rubiano L, Becerra- J. E, Rebolledo-Cobos R, Angarita J, Suárez-Marenco M. Póster Prevalencia y nivel de correlación entre la neuropatía diabética periférica y sus factores de riesgo en pacientes diabéticos tipo 2 del Hospital Universitario Erasmo Meoz. Erazo LN, Martínez JE, Meneses A. Póster Reporte de caso: resistencia a la insulina tipo B. Gómez A, Gómez C, Imitola A, Leguizamón G Frecuencia de síndrome metabólico en mujeres posmenopáusicas de cuatro municipios del departamento del atlántico, Colombia. Suárez Marenco M, Rebolledo-Cobos R, Becerra Enríquez J y Sarmiento Rubiano L. Póster Intentos para perder peso en una población con sobrepeso y obesidad referida a un centro de endocrinología en Colombia. Marín Carrillo LF, Ardila MA, Serrano-Gómez SE, Wandurraga EA Póster Niveles de IGF-1, variables hormonales y metabólicas en hombres obesos con síndrome metabólico comparados con obesos sin síndrome metabólico y hombres sanos con peso normal. Bernal MA, Romero MC, Alzate JP, Caminos E, Franco R. Póster Fenotipo clínico cintura hipertensión y su relación con otros factores cardiometabólicos. Cabrera-Rode E, del Carmen Borja A, Montes de Oca Somoano R, Cubas-Dueñas I, Rodríguez Acosta J, Arnold Domínguez Y, Hernández Rodríguez J, Díaz Díaz D. Póster Correlación entre el índice de masa corporal y densidad mineral ósea en mujeres posmenopáusicas. Jasqui Bucay A, Jasqui Romano S. Póster Factores que inciden en la adherencia al tratamiento farmacológico y no farmacológico de pacientes con diabetes mellitus. Amador E, Navarro G, Parody A y Montealegre L. Póster Determinación de niveles de glucemia y su asociación con obesidad como factor de riesgo para el desarrollo de diabetes mellitus tipo 2 en niños del Colegio Policarpa Salavarrieta (IED) en Bogotá. Moscoso JM, Méndez WA, Sierra LV, Tello KA. Póster Factores sociodemográficos y estilos de vida relacionados con el riesgo de diabetes tipo 2 en población adulta del barrio Las Flores, Barranquilla, Colombia. Rodríguez M, Mendoza MD. Póster Efectos del consumo del agraz colombiano (vaccinium meridionale swartz) en el perímetro abdominal y la resistencia a la insulina entre hombres y mujeres con síndrome metabólico. Galvis Y, Núñez V, Aristizábal J, Fernández ML, Barona J. Póster Efectos del agraz en inflamación y obesidad abdominal entre hombres y mujeres con síndrome metabólico. Galvis Y, Aristizábal J, Núñez V, Fernández ML, Barona J, Marín Echeverri C. Póster Análisis retrospectivo de datos reales de pacientes colombianos con diabetes mellitus tipo 2 tratados con exenatida. Romero ME, Buendía R, Navarrera A, Huérfano LM, Molano M, Romero Y, Vargas M. Póster Comparación de un modelo matemático con el simulador UVa/Padova en relación con el comportamiento de la glucemia en pacientes con DM1. Ramírez Rincón A. Rivadeneira PS, González A. Builes CE. Pizza Restrepo MJ. Póster Caracterización nutricional y antropométrica en una población en edad escolar de un centro educativo de Bogotá. Celis LG, Russi A, Munar LA, Lynett D Póster Caracterización genética de una familia colombiana que presenta obesidad mórbida. Yupanqui H, Yupanqui ME , Álvarez M , Restrepo C, Medina E, García A, Giraldo A , Arias A, Torres C y Celis LG. Póster Hemicorea–hemibalismo secundario a cetoacidosis diabética como presentación inicial de diabetes mellitus. García C.A., Ramírez R. Póster Variables psicológicas asociadas a cronicidad y complicaciones en pacientes con diabetes mellitus 2. Quiñones AT, Ugarte CA, Chávez CC y Mañalich JJ. Póster Caracterización de individuos con riesgo de desarrollar diabetes tipo 2 en la ciudad de Puyo, Ecuador. Espin BB, Mora E Póster Corea de larga duración asociada a hiperglucemia no cetósica en una paciente de etnia indígena. Espín BB, Altamirano A, Proaño SA. Póster Modelo semifísico de base fenomenológica del papel del intestino delgado en la homeostasis de la glucosa en humanos. Lema L, Builes CE, García JF, Ramírez A, Álvarez H. Póster Comparación de la infección urinaria en diabéticos, con otro tipo de infección urinaria complicada, en un hospital de tercer nivel en la ciudad de Barranquilla. Guevara E., González M., Maldonado N., Beltrán C., Osorio E., Patiño J. Póster Espectro clínico y radiológico del síndrome de corea-balismo asociado a hiperglucemia: revisión sistemática y metanálisis. Gómez Ochoa SA, Espín Chico BB, Pinilla Monsalve GD, Téllez Mosquera LE. Póster Interacción génica entre IRX3 y FTO asociada a exceso de peso y alteraciones metabólicas en adultos del Caribe colombiano. Mena Yi D, Ruiz Díaz MS, Gómez Camargo D, Mora García G. Póster Predictores de hipoglucemia en pacientes con diabetes mellitus tipo 2 e historia de hipoglucemia. Gómez AM, Henao DC, Parra DA, Robledo MA, Rebolledo M, Muñoz OM, Rondón M, García- Jaramillo M y León-Vargas F. Póster Prevalencia de obesidad abdominal en una población colombiana. Bolívar A, Rodríguez K, Vesga BE, Vera LM. Póster Implementación práctica de un modelo matemático de predicción de glucemia pacientes con diabetes mellitus tipo 1 en terapia funcional de insulina. Ramírez Rincón A. Rivadeneira PS, González A, Builes CE y Pizza Restrepo MJ. Póster Factores asociados con alta variabilidad glucémica definida por coeficiente de variación en pacientes con diabetes mellitus tipo 2 y alto riesgo de hipoglucemia. Gómez AM, Henao DC, Rondón M, Muñoz OM, Taboada L, Sanko A, García-Jaramillo M y León- Vargas F. Póster Experiencia en el manejo de pacientes con insulinoma: una serie de casos. Guzmán GE, Victoria AM, Candelo KD, Arguello P, Feriz KM, Casas LA, Arango LG, López A y Martínez V. Póster Correlación de la tasa de filtración glomerular medida versus calculada en obesos. Buenaventura DC, Martínez V, Durán CE, Escalante M, Martínez MF, Maldonado A, Pacheco R, Guzmán GE. Póster Aplicación del “modelo para el estudio de hipersensibilidad a medicamentos basado en bucilamina y el alelo HLa-DRB1*08:02 en poblaciones amerindias colombianas” para demostrar la relación entre la expresión de alelos HLa específicos y la hipersensibilidad a la insulinoterapia. Botero AC, Parga CH, Peñaranda N, Santodomingo NE.

BackgroundMigraine is a chronic neurological disease causing significant socioeconomic burden and impaired quality of life. Chinese medicine is commonly used for migraine in China. Clinical trials have generated evidence of the effectiveness of Chinese medicine therapies for migraine. However, little is known about how to use these therapies to treat migraine in real-world clinical settings.MethodsIn this retrospective study, we analyzed data from the electronic medical records (EMRs) of 2,023 migraine patients who attended the Guangdong Provincial Hospital of Chinese Medicine (GPHCM) between July 2018 and July 2020.ResultsMore than three-quarters (77.21%) of the patients were female. Most (78.20%) of the patients were aged between 18 and 50 years, 18.49% were aged above 50 years, and the remaining 3.31% were under 18 years. Sleep disorders were the most documented comorbidity occurring in 27.29% of patients, and more common in females (29.77%) than male (18.87%). Fatigue was the most frequently reported trigger of migraine attacks among all patients (9.39%), while menstruation was the most common trigger for female patients (10.24%). Less than a quarter of patients (21.01%) reported a history of taking analgesic medication for their migraine. The median treatment duration reported by the patients was 10 days. Chinese herbal medicine (CHM) was the predominant treatment for migraine at the hospital (88.48%), while pharmacotherapies were prescribed to 28.97% of the patients. CHM was prescribed more often as a sole treatment (53.58% of patients) than combined with pharmacotherapies (27.39% of patients). Among patients who reported improvements after taking CHM, the most frequently used herbs were fu ling and chuan xiong, the most frequent patented CHM product was tong tian oral solution, and the main herbal formulae were chuan xiong cha tiao san and yi qi cong ming tang.ConclusionCHM formulae, such as chuan xiong cha tiao san and yi qi cong ming tang, patented CHM product tong tian oral solution, and some herbs are potentially effective treatments for migraine. As such, CHM can be used as an alternative to conventional pharmacotherapies for migraine and is worth further evaluation in randomized controlled trials.

AbstractThe local-styled tombs of the Warring-States Period to the Western Han Dynasty recovered at Kele Site in Hezhang County, Guizhou Province had rich cultural connotations and distinct features, the “head encasing” burial custom of which was especially unique. These tombs showed sharp differences to the Han-styled tombs in the same cemetery and other regional cultural remains in peripheral areas and represented a new archaeological culture in the Xinan Yi (Southwest Barbarians) Region of the Warring-States to the Qin-Han Periods, which could be named as “Kele Culture”. The putting forward of the concept of “Kele Culture” and the research on it had great academic significance; they will positively influence the archaeological researches on the Xinan Yi Region of the Warring-States to the Qin-Han Periods and lay firm foundation for the in-depth archaeological exploration of Yelang Culture.

AbstractIn July through September 2012, the tomb of Mme Yi, the De Consort of the Later Tang Dynasty was excavated. It was a brick multi-chamber tomb consisting of the passage, the entrance, the corridor, the main chamber and the side chambers, the full length of which was 24.1m. 208 pieces (sets) of grave goods were unearthed from this tomb, including porcelains, silver and bronze wares, iron objects, bone implements, lacquer wares, architectural parts and the epitaph. This tomb show more styles of the Han Culture, which was special among the tombs of the Liao Dynasty of the same time. The content of the epitaph made up the insufficient records of the historical textual materials and provided important materials for the researches on the relationship between the Khitan and the Later Tang and Later Jin Dynasties in the Five-Dynasties Period.