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Articles de revues sur le sujet « Cyclocurcumine »

Auteur : Grafiati

Publié le 8 juin 2024

Mis à jour le 31 juillet 2025

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1

Losantos, Raúl, Jérémy Pecourneau, Maxime Mourer, Stéphane Parant, Andreea Pasc, and Antonio Monari. "trans–cis Photoisomerization of a biomimetic cyclocurcumin analogue rationalized by molecular modelling." Physical Chemistry Chemical Physics 23, no. 22 (2021): 12842–49. http://dx.doi.org/10.1039/d1cp01224j.

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The photoisomerization process of a biomimetic cyclocurcumin derivative is explored by molecular modelling. It presents enhanced capabilities respect to natural cyclocurcumin in terms of isomerization, TPA and environment dependency.

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Gasbarri, Carla, and Guido Angelini. "Cyclocurcumin as Promising Bioactive Natural Compound: An Overview." Molecules 29, no. 7 (2024): 1451. http://dx.doi.org/10.3390/molecules29071451.

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Although identical in molecular formula and weight, curcumin and cyclocurcumin show remarkable differences in their reactivity. Both are natural compounds isolated from the rhizome of turmeric, the former is involved in the diketo/keto-enol tautomerism through the bis-α,β-unsaturated diketone unit according to the polarity of the solvent, while the latter could react by trans-cis isomerization due to the presence of the α,β-unsaturated dihydropyranone moiety. Even if curcumin is generally considered responsible of the therapeutical properties of Curcuma longa L. due to its high content, cycloc

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Kesharwani, Rajesh K., Simran Kumari, Dev Bukhsh Singh, and Sandeep Tripathi. "A Docking Simulation Study of Some Herbal Molecules Against Influenza A Virus by Targeting Neuraminidase." Current Traditional Medicine 6, no. 2 (2020): 147–54. http://dx.doi.org/10.2174/2215083805666190808092031.

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Background: Human Swine flu is a viral disease caused by Influenza A virus, an orthomyxovirus, contains the glycoprotein neuraminidase described as H1N2. Neuraminidase, a glycoside hydrolase enzyme assist in budding from the host cells. The medicines available for the treatment of swine flu are Oseltamivir and Zanamivir acting against glycoproteins, mainly haemagglutinin and neuraminidase. Ayurvedic medicinal system described many herbs which acts as antiviral and among that Curcumin, Bisdemethoxycurcumin, Cyclocurcumin, Ascorbic Acid and Eugenol have been selected based on their potential ant

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Adhikary, Ramkrishna, Charles A. Barnes, Rachel L. Trampel, Samuel J. Wallace, Tak W. Kee, and Jacob W. Petrich. "Photoinducedtrans-to-cisIsomerization of Cyclocurcumin." Journal of Physical Chemistry B 115, no. 36 (2011): 10707–14. http://dx.doi.org/10.1021/jp200080s.

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Li, Yunkui, Marirosa Toscano, Gloria Mazzone, and Nino Russo. "Antioxidant properties and free radical scavenging mechanisms of cyclocurcumin." New Journal of Chemistry 42, no. 15 (2018): 12698–705. http://dx.doi.org/10.1039/c8nj01819g.

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Kim, Keunyoung, Jung-Jun Kim, Yeryeon Jung, et al. "Cyclocurcumin, an Antivasoconstrictive Constituent ofCurcuma longa(Turmeric)." Journal of Natural Products 80, no. 1 (2017): 196–200. http://dx.doi.org/10.1021/acs.jnatprod.6b00331.

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Marazzi, Marco, Antonio Francés-Monerris, Maxime Mourer, Andreea Pasc, and Antonio Monari. "Trans-to-cis photoisomerization of cyclocurcumin in different environments rationalized by computational photochemistry." Physical Chemistry Chemical Physics 22, no. 8 (2020): 4749–57. http://dx.doi.org/10.1039/c9cp06565b.

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Solvent effects determine the fate of cyclocurcumin photochemistry: in non-polar environments fluorescence is preferred, while in polar solvents the photoisomerization path is opened, paving the way to applications as chemosensors and for theranostic purposes.

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Ngo, Thien, Keunyoung Kim, Yiying Bian, et al. "Cyclocurcumin from Curcuma longa selectively inhibits shear stress-induced platelet aggregation." Journal of Functional Foods 61 (October 2019): 103462. http://dx.doi.org/10.1016/j.jff.2019.103462.

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Pecourneau, Jérémy, Raúl Losantos, Antonio Monari, Stéphane Parant, Andreea Pasc та Maxime Mourer. "Synthesis and Photoswitching Properties of Bioinspired Dissymmetric γ-Pyrone, an Analogue of Cyclocurcumin". Journal of Organic Chemistry 86, № 12 (2021): 8112–26. http://dx.doi.org/10.1021/acs.joc.1c00598.

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Losantos, Raúl, Giacomo Prampolini, and Antonio Monari. "A Portrait of the Chromophore as a Young System—Quantum-Derived Force Field Unraveling Solvent Reorganization upon Optical Excitation of Cyclocurcumin Derivatives." Molecules 29, no. 8 (2024): 1752. http://dx.doi.org/10.3390/molecules29081752.

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The study of fast non-equilibrium solvent relaxation in organic chromophores is still challenging for molecular modeling and simulation approaches, and is often overlooked, even in the case of non-adiabatic dynamics simulations. Yet, especially in the case of photoswitches, the interaction with the environment can strongly modulate the photophysical outcomes. To unravel such a delicate interplay, in the present contribution we resorted to a mixed quantum–classical approach, based on quantum mechanically derived force fields. The main task is to rationalize the solvent reorganization pathways i

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Goenka, Shilpi. "Cyclocurcumin, a Minor Curcuminoid, Is a Novel Candidate for Hypopigmentary Skin Disorders with Melanogenesis-Stimulating Capacity." Drugs and Drug Candidates 3, no. 2 (2024): 410–36. http://dx.doi.org/10.3390/ddc3020025.

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Effective therapies to treat skin hypopigmentation disorders caused by diminished melanin synthesis or export are limited due to potential side effects. In this work, we explored if cyclocurcumin (CYC), a curcuminoid found in minor amounts in turmeric rhizomes, might enhance the process of melanogenesis. CYC did not demonstrate antioxidant activity as evaluated by the DPPH assay. At noncytotoxic concentrations, CYC robustly enhanced melanin synthesis and melanin export in B16F10 mouse melanoma cells, which was correlated to increased cellular tyrosinase activity. The melanogenesis-stimulating

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Angelini, Guido, Axel Gansmüller, Jérémy Pécourneau, and Carla Gasbarri. "An insight into cyclocurcumin cis–trans isomerization: Kinetics in solution and in the presence of silver nanoparticles." Journal of Molecular Liquids 333 (July 2021): 116000. http://dx.doi.org/10.1016/j.molliq.2021.116000.

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Opustilová, Kristýna, Barbora Lapčíková, Lubomír Lapčík, Shweta Gautam, Tomáš Valenta, and Peng Li. "Physico-Chemical Study of Curcumin and Its Application in O/W/O Multiple Emulsion." Foods 12, no. 7 (2023): 1394. http://dx.doi.org/10.3390/foods12071394.

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Curcuma is a world-renowned herb known for its immense health benefits. In this study, physicochemical analyses were performed on the curcumin standard sample and curcumin multiple emulsions. The emulsions were analysed for thermal and structural stability for 21 days. Confocal laser microscopy (CLSM) was performed in order to observe the emulsion encapsulation. Modulated differential scanning calorimetry (MDSC) and HPLC methods revealed a variety of curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin, and cyclocurcumin) in the investigated curcumin standard. In addition, the MDSC

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Hidayah, Rizka Nurul, Belia Bima Nafisa, Miftah Saiful 'Arifin, Dewi Santosaningsih, and Roihatul Muti'ah. "Antiviral Activitiy of Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin and Cyclocurcumin compounds of Curcuma longa against NSP3 on SARS-CoV-2." Indonesian Journal of Cancer Chemoprevention 13, no. 3 (2023): 166. http://dx.doi.org/10.14499/indonesianjcanchemoprev13iss3pp166-174.

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SARS-CoV-2 genome encodes two large polyproteins (pp), pp1a and pp1ab which are cleaved and transformed into a mature form by a protease, non-structural protein 3 (NSP3). NSP3 is encoded by open reading frame (ORF) 1a/b. Curcuma longa (C. longa) or turmeric has been documented to have antiviral effects. The aim of this study was to assess the viral activities of C. longa against SARS-CoV-2 focusing on its potency to inhibit viral replication by targeting NSP3. PubChem databases were used to obtain the metabolic profile of C. longa. The compound's interaction with nucleocapsid was analyzed usin

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Nguyen, Thi Thu Ha, Thi Tu Anh Le, Thanh Tra Nguyen, and The Son Ninh. "Curcuminoids from the Vietnamese Curcuma longa: Phytochemical analysis and biological activities." Ministry of Science and Technology, Vietnam 64, no. 3 (2022): 19–23. http://dx.doi.org/10.31276/vjste.64(3).19-23.

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A phytochemical investigation on the ethanolic (EtOH) extract of the Vietnamese Curcuma longa (C. longa) rhizomes has led to the isolation of four curcuminoids including curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), and cyclocurcumin (4). The chemical structure of compounds 1-4 was elucidated by Nuclear magnetic resonance (NMR) and Mass spectrometry (MS) spectral data. Based on High-performance liquid chromatography (HPLC) quantitative analysis, the amounts of three major compounds 1-3 in the C. longa extract were calculated and reached 7.215±0.101, 3.927±0.031, and 2.255±0.04

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Hotsumi, Mayumi, Misato Tajiri, Koki Makabe та Hiroyuki Konno. "Design, synthesis and evaluation of diaryl γ-dihydropyrone derivatives as cyclocurcumin mimetics and inhibitors of the aggregation of amyloid β". Bioorganic Chemistry 104 (листопад 2020): 104302. http://dx.doi.org/10.1016/j.bioorg.2020.104302.

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Nair, Akhila, Augustine Amalraj, Joby Jacob, Ajaikumar B. Kunnumakkara, and Sreeraj Gopi. "Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations." Biomolecules 9, no. 1 (2019): 13. http://dx.doi.org/10.3390/biom9010013.

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Over the past decades curcuminoids have been extensively studied for their biological activities such as antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic, antifertility, antidiabetic, anticoagulant, antivenom, antioxidant, antihypotensive, antihypocholesteremic, and anticancer activities. With the perception of limited toxicity and cost, these compounds forms an integral part of cancer research and is well established as a potential anticancer agent. However, only few studies have focused on the other bioactive molecules of turmeric, known as non-curcuminoids, wh

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Alves, Daniela Ribeiro, Matheus Nunes da Rocha, Camila Caldas Oliveira Passos, Márcia Machado Marinho, Emmanuel Silva Marinho, and Selene Maia de Morais. "Curcumins and its derivatives as potential inhibitors of New Coronavirus (COVID-19) main protease: an in silico strategy." Research, Society and Development 11, no. 1 (2022): e6511124334. http://dx.doi.org/10.33448/rsd-v11i1.24334.

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Coronavirus (COVID-19) disease outbreak caused a worldwide pandemic with a powerful lethal potential and still, there is no specific treatment to it. Natural bioactive molecules like curcumins were investigated in this work aiming to block the active site of COVID-19 Main protease (Mpro), since they present several biological activities, being more suitable in terms of fewer side effects, once this disease overloads the immune system of patients. Hereby, curcumin and several derivatives were screened for their ability to react with Mpro receptors (PDB: 6LU7). N3, Azithromycin (AZT), and Baraci

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Santoro, Angelo, Antonio Ricci, Manuela Rodriquez, Michela Buonocore та Anna Maria D’Ursi. "A Structural Effect of the Antioxidant Curcuminoids on the Aβ(1–42) Amyloid Peptide". Antioxidants 14, № 1 (2025): 53. https://doi.org/10.3390/antiox14010053.

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Investigating amyloid–β (Aβ) peptides in solution is essential during the initial stages of developing lead compounds that can influence Aβ fibrillation while the peptide is still in a soluble state. The tendency of the Aβ(1–42) peptide to misfold in solution, correlated to the aetiology of Alzheimer’s disease (AD), is one of the main hindrances to characterising its aggregation kinetics in a cell-mimetic environment. Moreover, the Aβ(1–42) aggregation triggers the unfolded protein response (UPR) in the endoplasmic reticulum (ER), leading to cellular dysfunction and multiple cell death modalit

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Indradi, Raden Bayu, Dian Ayu Eka Pitaloka, and Suryani Suryani. "Network pharmacology to uncover potential anti-inflammatory and immunomodulatory constituents in Curcuma longa rhizome as complementary treatment in COVID-19." Pharmacia 69, no. 4 (2022): 995–1003. http://dx.doi.org/10.3897/pharmacia.69.e89799.

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The immune status of patients plays an essential role in COVID-19. Herbal medicine with immunomodulatory and anti-inflammatory effect could have potential as a complementary therapeutic along with modern medicine. This study aims to investigate the anti-inflammatory and immunomodulatory constituents of Curcuma longa (C. longa) and its possible mechanisms in COVID-19. We systematically sorted the biochemical of C. longa rhizome from literature and repository. Next, we investigated targets related to COVID-19 in the selected active phytochemical constituents and analyzed the possible mechanisms

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Indradi, Raden Bayu, Dian Ayu Eka Pitaloka, and Suryani Suryani. "Network pharmacology to uncover potential anti-inflammatory and immunomodulatory constituents in Curcuma longa rhizome as complementary treatment in COVID-19." Pharmacia 69, no. (4) (2022): 995–1003. https://doi.org/10.3897/pharmacia.69.e89799.

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The immune status of patients plays an essential role in COVID-19. Herbal medicine with immunomodulatory and anti-inflammatory effect could have potential as a complementary therapeutic along with modern medicine. This study aims to investigate the anti-inflammatory and immunomodulatory constituents of Curcuma longa (C. longa) and its possible mechanisms in COVID-19. We systematically sorted the biochemical of C. longa rhizome from literature and repository. Next, we investigated targets related to COVID-19 in the selected active phytochemical constituents and analyzed the possible mechanisms

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Fu, Min, Lihui Chen, Limin Zhang, Xiao Yu, and Qingrui Yang. "Cyclocurcumin, a curcumin derivative, exhibits immune-modulating ability and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method." International Journal of Molecular Medicine 39, no. 5 (2017): 1164–72. http://dx.doi.org/10.3892/ijmm.2017.2926.

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Pundir, Hemlata, Ramanand Pathak, Tanuja Pant, Manish Pant, Subhash Chandra, and Sushma Tamta. "In Silico Screening of Phytochemicals Targeting SmdCD of Streptococcus mutans using Molecular Docking Approach." Trends in Sciences 20, no. 6 (2023): 6036. http://dx.doi.org/10.48048/tis.2023.6036.

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Introduction: Dental caries is a chronic infectious disease caused by bacteria forming a biofilm formation on the tooth surface. Drug-resistant bacteria Streptococcus mutans (S. mutans) pose a vital public health issue. To overcome this, the development of effective drugs with a novel mechanism of action is very important. Drug repurposing is considered a viable alternative approach to overcome the above issue. In the present study, we have attempted to select unique and traditional source used as in traditional medicine. To continue this effort, in this study we used phytochemical of selected

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Delova, Anastasiia, Raul Losantos, Jérémy Pecourneau, Maxime Mourer, Andreea Pasc, and Antonio Monari. "Modelling the effects of E/Z photoisomerization of a cyclocurcumin analogue on the properties of cellular lipid membranes." Physical Chemistry Chemical Physics, 2023. http://dx.doi.org/10.1039/d3cp02955g.

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We study a cyclocurcumin analogue interacting with lipid membranes. The formation of stable membrane aggregates is confirmed as well as the perturbation induced by E/Z isomerization, thus making it a good candidate for light-induced chemotherapy.

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Rajagopal, Kalirajan, Potlapati Varakumar, Aparma Baliwada, and Gowramma Byran. "Activity of phytochemical constituents of Curcuma longa (turmeric) and Andrographis paniculata against coronavirus (COVID-19): an in silico approach." Future Journal of Pharmaceutical Sciences 6, no. 1 (2020). http://dx.doi.org/10.1186/s43094-020-00126-x.

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Abstract Background In early 2020, many scientists are rushing to discover novel drugs and vaccines against the coronavirus, and treatments for COVID-19, because coronavirus disease 2019 (COVID-19), a life-threatening viral disease, affected first in China and quickly spread throughout the world. In this article, in silico studies have been performed to explore the binding modes of chemical constituents for natural remedies like Curcuma longa (turmeric) and Andrographis paniculata against COVID-19 (PDB ID 5R82) targeting coronavirus using Schrodinger suit 2019-4. The molecular docking studies

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MANDAL, SAJAL, and SHUBHAM WANARASE. "IN SILICO APPROACH TO IDENTIFY POTENTIAL ANTI-PSORIATIC COMPOUNDS FROM CURCUMA LONGA." Innovare Journal of Medical Sciences, July 6, 2023, 1–6. http://dx.doi.org/10.22159/ijms.2023.v11i4.47979.

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Objectives: Psoriasis is a type of skin disease which is accompanied with over production of keratinocytes, itchiness, and scaly skin. In this study, an attempt was made to recognize naturally occurring phytocompounds from the plant Curcuma longa which can be helpful in treating psoriasis using molecular docking techniques. Methods: The protein associated to the mechanism of psoriasis was obtained from the protein data bank database, along with retrieving the phytocompounds from C. longa. The phytocompounds were docked with the protein using PyRx docking. Further, analysis was done using Swiss

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Lu, Han, Jingyi Zheng, Chunnan Hu, et al. "Cyclocurcumin potently inhibits human aromatase as a potential therapeutic agent." Journal of Steroid Biochemistry and Molecular Biology, December 2024, 106672. https://doi.org/10.1016/j.jsbmb.2024.106672.

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Delova, Anastasiia, Raúl Losantos, Jérémy Pecourneau, et al. "Perturbation of Lipid Bilayers by Biomimetic Photoswitches Based on Cyclocurcumin." Journal of Chemical Information and Modeling, December 8, 2022. http://dx.doi.org/10.1021/acs.jcim.2c01152.

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Pecourneau, Jérémy, Raúl Losantos, Axel Gansmuller, et al. "Tuning the competition between photoisomerization and photothermy in biomimetic cyclocurcumin analogues." Journal of Photochemistry and Photobiology A: Chemistry, January 2023, 114583. http://dx.doi.org/10.1016/j.jphotochem.2023.114583.

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"Analysis of Phytochemicals from Camptotheca acuminata, Curcuma longa, and Diphylleia grayi Against a Complex of ERK2 with Catechol." Letters in Applied NanoBioScience 13, no. 3 (2024): 141. https://doi.org/10.33263/lianbs133.141.

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Cancer remains a daunting global health challenge that requires continuous efforts to understand its underlying mechanisms and develop novel therapeutic strategies. This comprehensive research focuses on recent advances in cancer research, focusing on emerging therapies and the challenges encountered in the fight against this complex disease. This work used different phytochemicals obtained from Camptotheca acuminata, Curcuma longa, and Diphylleia grayi to verify the Complex of ERK2 with Catechol (PDB - 4ZXT), a receptor for lung cancer. The complex of ERK2 with Catechol was used to study the

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Chakraborty, Sandeep, Artashes Karmenyan, Jin-Wu Tsai, and Arthur Chiou. "Inhibitory effects of curcumin and cyclocurcumin in 1-methyl-4-phenylpyridinium (MPP+) induced neurotoxicity in differentiated PC12 cells." Scientific Reports 7, no. 1 (2017). http://dx.doi.org/10.1038/s41598-017-17268-3.

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Pundir, Hemlata, Tanuja Pant, Ramanand Pathak, Manish Pant, Subhash Chandra, and Sushma Tamta. "In silico Screening of Potential Compounds from Medicinal Plants by Targeting Streptococcus mutans Deoxycytidylate Deaminase." Journal of Pharmaceutical Research International, December 15, 2022, 1–11. http://dx.doi.org/10.9734/jpri/2022/v34i567249.

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Dental caries is the chronic infectious disease caused by bacteria to from a biofilm formation on the tooth surface of man. Drug-resistant Streptococcus mutans (S. mutans) poses a vital public health issue. To overcome this, the development of effective drugs with novel mechanism of action is requisite. Drug repurposing is considered a viable alternative approach to overcome the above issue. In the present study, we have attempted to selected unique and traditional source use as in traditional medicine. Traditionally, many cultures use chewing sticks for oral hygiene maintenance. When properly

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Dewi, Tanaya Jati Dharma, Mohammad Mohammad Ihda Faiz Sya'bana, Abdul Wafi, Burhan Ma’arif, and Luthfi Ahmad Muchlasi. "In Silico Study of Curcuminoid Compounds in Turmeric ( Curcuma longa) Plants as Halal Anticoagulant Active Ingredients." Journal of Islamic Medicine 7, no. 2 (2023). https://doi.org/10.18860/jim.v7i2.24568.

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Background: Thrombosis is a condition when there is a reduction in the flow of blood fluid in the blood vessels that occurs due to the process of forming blood clots. One of the drugs most often used as an anticoagulant is enoxaparin. Enoxaparin itself is obtained by depolymerizing the base of heparin benzyl ester which is derived directly from the intestinal mucosa of pigs so that its use triggers a lot of controversy by Muslims. The mechanism of action of enoxaparin is to act as an antithrombin III catalyst which functions to inhibit the formation of blood clots by factor X. The curcumin com

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Gasbarri, Carla, та Guido Angelini. "Combined calorimetric, spectroscopic and microscopic investigation on the inclusion complex from cyclocurcumin and sulfobutylether-β-cyclodextrin in aqueous solution and Kinetics of thermal cis-trans isomerization". Colloids and Surfaces A: Physicochemical and Engineering Aspects, лютий 2023, 131149. http://dx.doi.org/10.1016/j.colsurfa.2023.131149.

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