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Articles de revues sur le sujet « Discriminatory Dissolution »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Amaral Silva, Daniela, Jozef Al-Gousous, Neal M. Davies, et al. "Biphasic Dissolution as an Exploratory Method during Early Drug Product Development." Pharmaceutics 12, no. 5 (2020): 420. http://dx.doi.org/10.3390/pharmaceutics12050420.

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Dissolution testing is a major tool used to assess a drug product’s performance and as a quality control test for solid oral dosage forms. However, compendial equipment and methods may lack discriminatory power and the ability to simulate aspects of in vivo dissolution. Using low buffer capacity media combined with an absorptive phase (biphasic dissolution) increases the physiologic relevance of in vitro testing. The purpose of this study was to use non-compendial and compendial dissolution test conditions to evaluate the in vitro performance of different formulations. The United States Pharma

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Ashokraj, Yasvanth, Atul Daroi, Raja Gupta, et al. "Discriminatory Dissolution Method Development and Validation of Etoricoxib Tablets." Dissolution Technologies 23, no. 2 (2016): 30–34. http://dx.doi.org/10.14227/dt230216p30.

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Kaur, Parmar, and Bansal. "Evaluation of Different Techniques for Size Determination of Drug Nanocrystals: A Case Study of Celecoxib Nanocrystalline Solid Dispersion." Pharmaceutics 11, no. 10 (2019): 516. http://dx.doi.org/10.3390/pharmaceutics11100516.

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Celecoxib (CEL) Nanocrystalline Solid Dispersion (CEL_NCSD) was generated by spray drying CEL, mannitol (MAN) and sodium lauryl sulfate (SLS) from a solvent mixture of methanol, acetone and water. The purpose of the work was to determine the size of CEL nanocrystals, investigate agglomeration and inspect dissolution of CEL_NCSD. Size determination was challenging as CEL nanocrystals are embedded in the matrix of MAN. Firstly, neat CEL_NCSD was analyzed using Scherrer equation. Secondly, MAN was dissolved in an aqueous stabilizer medium to selectively measure the size of CEL nanocrystals. Raman

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Singh, SachinK, KK Srinivasan, K. Gowthamarajan, and GB Narayan. "Development and validation of discriminatory dissolution procedure for poorly soluble glyburide." Asian Journal of Pharmaceutics 4, no. 4 (2010): 205. http://dx.doi.org/10.4103/0973-8398.76744.

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Singla, N., G. D. Gupta, K. Kohli, and A. K. Singla. "A Discriminatory and Biorelevant Dissolution Test Method for Simvastatin Drug Products." Dissolution Technologies 16, no. 4 (2009): 11–13. http://dx.doi.org/10.14227/dt160409p11.

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Silva, Ana Paula Cappra, Leonardo Zanchetti Meneghini, Lisiane Bajerski, et al. "Discriminatory Dissolution Test for Tablets Containing a- and b-Thalidomide Polymorphs." Dissolution Technologies 20, no. 1 (2013): 19–25. http://dx.doi.org/10.14227/dt200113p19.

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Dharani, Sathish, Sogra F. Barakh Ali, Hamideh Afrooz, Mansoor A. Khan, and Ziyaur Rahman. "Development and Validation of a Discriminatory Dissolution Method for Rifaximin Products." Journal of Pharmaceutical Sciences 108, no. 6 (2019): 2112–18. http://dx.doi.org/10.1016/j.xphs.2019.01.020.

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Kaur, Sharanpreet, Navreet Kaur, Gursimran Kaur, and Prabhat Kumar. "A Review on Fluconazole." Journal for Research in Applied Sciences and Biotechnology 2, no. 3 (2023): 41–43. http://dx.doi.org/10.55544/jrasb.2.3.6.

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The improvement of a significant dissolution manner for drug merchandise with restrained water solubility has been a project to the pharmaceutical industry. fluconazole (BCS Class 1 drug) is an anti-fungal drug. There isn't any reputable dissolution medium to be had withinside the literature. In the prevailing study, parameters inclusive of solubility, medium pH, surfactant type, dissolution behaviour of formulations, impact of sink situations, stability, and discriminatory impact of dissolution checking out had been studied for the choice of a right dissolution medium. Results of solubility f

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Anumolu, Panikumar Durga, Sirisha Neeli, Haripriya Anuganti, Sathesh Babu Puvvadi Ranganatham, and Subrahmanyam Chavali Venkata Satya. "Development of dissolution test method for a telmisartan/amlodipine besylate combination using synchronous derivative spectrofluorimetry." Brazilian Journal of Pharmaceutical Sciences 50, no. 2 (2014): 329–36. http://dx.doi.org/10.1590/s1984-82502014000200012.

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The dissolution process is considered an important in vitro tool to evaluate product quality and drug release behavior. Single dissolution methods for the analysis of combined dosage forms are preferred to simplify quality control testing. The objective of the present work was to develop and validate a single dissolution test for a telmisartan (TEL) and amlodipine besylate (AML) combined tablet dosage form. The sink conditions, stability and specificity of both drugs in different dissolution media were tested to choose a discriminatory dissolution method, which uses an USP type-II apparatus wi

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Mohammed Abdulzahra Hussein and Mohanad Naji Sahib. "The predictive power of biphasic dissolution approach using Class IV model drug." Al Mustansiriyah Journal of Pharmaceutical Sciences 23, no. 2 (2023): 221–30. http://dx.doi.org/10.32947/ajps.v23i2.1024.

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This study was aimed to evaluate biphasic dissolution system and its applicability to discriminate between different formulas. Two different tablet formulas of furosemide were prepared using dry compression (F1) and wet granulation (F2). The prepared formulas were evaluated for hardness, friability and disintegration. Thereafter, monophasic and biphasic dissolution systems were used to compare the dissolution profiles of the prepared formulas with a commercially available tablet. The results of the physical properties of the prepared tablets were within acceptable values. Moreover, there

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Cristofoletti, Rodrigo, and Jennifer B. Dressman. "Dissolution Methods to Increasing Discriminatory Power of In Vitro Dissolution Testing for Ibuprofen Free Acid and Its Salts." Journal of Pharmaceutical Sciences 106, no. 1 (2017): 92–99. http://dx.doi.org/10.1016/j.xphs.2016.06.001.

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Franc, Aleš, Jan Muselłk, Roman Goněc, and David Vetchý. "Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts." Acta Pharmaceutica 66, no. 1 (2016): 139–45. http://dx.doi.org/10.1515/acph-2016-0010.

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Abstract Substances in the form of weak acid salts have been found to be problematic for dissolution testing. Their absorption can start only after they are turned into the form of an acid following the gastric passage although they were administered in the form of a salt. Due to poor solubility, they cannot be tested in acidic gastric environment for a biased dissolution profile. The biphasic dissolution method is promising for overcoming this obstacle. Tablets with warfarin clathrate sodium salt in two concentrations and two different particle size distributions were tested as a suitable mod

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Pawar, Harshal Ashok, and Pooja Rasiklal Joshi. "Development and Validation of a Discriminating In Vitro Dissolution Method for Oral Formulations Containing Satranidazole." International Journal of Spectroscopy 2014 (April 24, 2014): 1–7. http://dx.doi.org/10.1155/2014/624635.

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The development of a meaningful dissolution procedure for drug products with limited water solubility has been a challenge to the pharmaceutical industry. Satranidazole (BCS Class II drug) is a new nitroimidazole derivative with potent antiamoebic action. There is no official dissolution medium available in the literature. In the present study, parameters such as saturation solubility in different pH medium, dissolution behavior of formulations, influence of sink conditions, stability, and discriminatory effect of dissolution testing were studied for the selection of a proper dissolution mediu

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Khan, Amjad, Zafar Iqbal, Aman Ullah, Ibrahim Khadra, Mehrin Sherazi, and Noreen Zeb. "Discriminatory Dissolution Testing for Liquisolid Compacts Containing a Poorly Water-Soluble Drug (Hydrochlorothiazide)." Dissolution Technologies 26, no. 1 (2019): 46–54. http://dx.doi.org/10.14227/dt260119p46.

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Mitrevska, Ivana, Katerina Brezovska, Aneta Dimitrovska, Suzan Memed-Sejfulah, and Sonja Ugarkovic. "Optimization and statistical evaluation of discriminative dissolution method for bisoprolol immediate-release film coated tablets." Macedonian Pharmaceutical Bulletin 66, no. 1 (2020): 43–53. http://dx.doi.org/10.33320/maced.pharm.bull.2020.66.01.005.

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This study presents optimization of a statistically based approach for setting up the dissolution test conditions for bisoprolol film-coated tablets using multivariate release models as predictive in vivo assessment tools for formulation behaviour. Additionally, the dissolution profiles of three different strengths of bisoprolol film-coated tablets were evaluated. According to the biopharmaceutics classification system, the tested medicinal product belongs to BCS Class I (high solubility, high permeability). Three dissolution media, including the dissolution medium of choice (pH 1.2) according

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Mitrevska, Ivana, Tina Achkoska, Katerina Brezovska, Krume Toshev, Aneta Dimitrovska, and Sonja Ugarkovic. "Development and Validation of Discriminative Dissolution Method for Metformin Immediate-Release Film-Coated Tablets." Journal of Analytical Methods in Chemistry 2019 (December 10, 2019): 1–8. http://dx.doi.org/10.1155/2019/4296321.

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The purpose of this study was to develop and validate a discriminative dissolution method for the metformin film-coated tablet with immediate release of the active substance that belongs to class III of the Biopharmaceutical Classification System (BCS). Different conditions such as type of dissolution medium, volume of dissolution medium, rotation speed, apparatus, and filter suitability were evaluated. The most discriminative release profile for the metformin film-coated tablet was accomplished by using Apparatus II (paddle) and 1000 mL of phosphate buffer pH 6.8 as the dissolution medium and

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J R, Medina-López, Ríos-López A, and Reyes-Ramírez F D. "Convolution approach to estimate the in vivo behavior of ibuprofen soft gelatin capsules from in vitro release data of USP Apparatus 4." International Journal of Research in Pharmaceutical Sciences 15, no. 4 (2024): 88–94. https://doi.org/10.26452/ijrps.v15i4.4727.

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Hypothetical plasma concentration-time profiles of ibuprofen gelatin soft capsules were calculated using data from the USP apparatus IV (flow-through cell method). Four ibuprofen formulations (reference and generic products at 400 and 600 mg) were tested with laminar flow at 16 ml/min in pH 6.8 phosphate buffer. Samples were withdrawn at 10, 20, 30, 45, and 60 minutes, and dissolved drug levels were measured using UV derivative spectrophotometric analysis. Dissolution curves were compared by calculating model-dependent and model-independent parameters, employing Student’s t-test for statistica

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Hulse, Wendy L., Jason Gray, and Robert T. Forbes. "A discriminatory intrinsic dissolution study using UV area imaging analysis to gain additional insights into the dissolution behaviour of active pharmaceutical ingredients." International Journal of Pharmaceutics 434, no. 1-2 (2012): 133–39. http://dx.doi.org/10.1016/j.ijpharm.2012.05.023.

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Tambe, Srushti, and Namita Desai. "Development and Evaluation of Bioresponsive Tablets of a Selective COX-2 Inhibitor for Colonic Delivery." Drug Delivery Letters 10, no. 1 (2020): 72–83. http://dx.doi.org/10.2174/2210303109666190828095726.

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Background: We report the effectiveness of a targeted delivery system containing Meloxicam using polysaccharides for the treatment of colorectal cancer. We also propose a novel biorelevant dissolution method to overcome drawbacks of existing dissolution methodologies of polysaccharidebased systems. The proposed method includes a mixture of probiotics cultured under anaerobic conditions in the presence of prebiotic in the in vitro dissolution study to surrogate colonic conditions. Polysaccharide- based system can be simple, safe and effective drug delivery system to target drugs to colon. Metho

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Bílik, Tomáš, Jan Elbl, Kateřina Kubová, et al. "Golem V2 Biorelevant Dissolution Device: Tapping the Potential in Prolonged Release Matrix Tablets." Acta Poloniae Pharmaceutica - Drug Research 81, no. 5 (2025): 851–67. https://doi.org/10.32383/appdr/199377.

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Dynamic biorelevant dissolution devices are becoming an important part of pharmaceutical research and development. Golem v2 represents such instrument. The aim of the study was to examine its potential for standard hydrophilic, lipophilic and dual matrices evaluation. The effect of agitation rate was observed. The obtained profiles were assessed by difference and similarity factors, compared to USP II profiles. Selected kinetic and release mechanism models were employed. Hydrophilic matrices differed in modified release excipient hydroxypropylmethylcellulose (10 to 30%) and apart the lowest 10

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Khan, Amjad. "Development and Validation of a Discriminatory Dissolution Testing Method for Orally Disintegrating Tablets (ODTs) of Domperidone." Dissolution Technologies 24, no. 2 (2017): 28–36. http://dx.doi.org/10.14227/dt240217p28.

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Xu, Caihong, Meijuan Zou, Yiping Wang, et al. "Discriminatory dissolution method for quality control measurements of carbamazepine immediate release tablets based onin vitro–in vivoinvestigations." Drug Development and Industrial Pharmacy 38, no. 6 (2011): 679–88. http://dx.doi.org/10.3109/03639045.2011.621433.

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Qureshi, Saeed A. "Developing Discriminatory Drug Dissolution Tests and Profiles: Some Thoughts for Consideration on the Concept and Its Interpretation." Dissolution Technologies 13, no. 4 (2006): 18–23. http://dx.doi.org/10.14227/dt130406p18.

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Yi, Hanxi, Fan Liu, Guoqing Zhang, and Zeneng Cheng. "Evaluation of a Modified Flow-Through Method for Predictive Dissolution and In Vitro/In Vivo Correlations of Immediate Release and Extended Release Formulations." Journal of Nanomaterials 2021 (April 27, 2021): 1–10. http://dx.doi.org/10.1155/2021/9956962.

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The present study evaluated the ability of a modified flow-through method for predicting in vivo performance of immediate release (IR) and extended release (ER) formulations. In vitro dissolution of two model drugs, paracetamol IR tablets and felodipine ER tablets, was investigated under tuned conditions using the modified flow-through method and compared with the compendial quality control (QC) basket method. The in vivo absorption properties of paracetamol IR tablets and felodipine ER tablets were investigated in healthy volunteers. In vitro-in vivo correlation (IVIVC) analysis was performed

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Gupta, Ritu, Yuan Chen, Mahua Sarkar, and Huan Xie. "Surfactant Mediated Accelerated and Discriminatory In Vitro Drug Release Method for PLGA Nanoparticles of Poorly Water-Soluble Drug." Pharmaceuticals 15, no. 12 (2022): 1489. http://dx.doi.org/10.3390/ph15121489.

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In vitro drug release testing is an important quality control tool for formulation development. However, the literature has evidence that poly-lactide-co-glycolide (PLGA)-based formulations show a slower in vitro drug release than a real in vivo drug release. Much longer in vitro drug release profiles may not be reflective of real in vivo performances and may significantly affect the timeline for a formulation development. The objective of this study was to develop a surfactant mediated accelerated in vitro drug release method for the PLGA nanoparticles (NPs) of a novel chemotherapeutic agent

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Kolla, Sudheer Babu, Madhusudhan Rao Vallabhaneni, Srinivasa Babu Puttagunta, and Maharshi Sudulagunta Venkata. "Design of Experiments Approach to Discriminatory Dissolution Method Development of Poorly Soluble Drug in Immediate Release Dosage Form." Indian Journal of Pharmaceutical Education and Research 53, no. 3 (2019): 435–45. http://dx.doi.org/10.5530/ijper.53.3.76.

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Al-Tabakha, Moawia M., and Muaed J. Alomar. "In Vitro Dissolution and in Silico Modeling Shortcuts in Bioequivalence Testing." Pharmaceutics 12, no. 1 (2020): 45. http://dx.doi.org/10.3390/pharmaceutics12010045.

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Purpose: To review in vitro testing and simulation platforms that are in current use to predict in vivo performances of generic products as well as other situations to provide evidence for biowaiver and support drug formulations development. Methods: Pubmed and Google Scholar databases were used to review published literature over the past 10 years. The terms used were “simulation AND bioequivalence” and “modeling AND bioequivalence” in the title field of databases, followed by screening, and then reviewing. Results: A total of 22 research papers were reviewed. Computer simulation using softwa

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Jadhav, Sanika, Amanpreet Kaur, and Arvind Kumar Bansal. "Comparison of Downstream Processing of Nanocrystalline Solid Dispersion and Nanosuspension of Diclofenac Acid to Develop Solid Oral Dosage Form." Pharmaceutics 12, no. 11 (2020): 1015. http://dx.doi.org/10.3390/pharmaceutics12111015.

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The conventional “top-down”, “bottom-up” and “combination” approaches of generating drug nanocrystals produce a “nanosuspension” (NS). It requires significant downstream processing for drying the liquid by suitable means followed by its granulation to develop an oral solid dosage form (OSD). In this paper, we used a novel, spray drying-based NanoCrySP technology for the generation of drug nanocrystals in the form of nanocrystalline solid dispersion (NCSD). We hypothesized that the NCSD would require minimal downstream processing since the nanocrystals are obtained in powder form during spray d

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Amer, Ahmed M., Ahmed N. Allam, and Ossama Y. Abdallah. "Evaluation of the Discriminatory Power of USP Dissolution Method for Candesartan Cilexetil Tablets through Testing of Marketed Products in Egypt." Dissolution Technologies 25, no. 4 (2018): 40–46. http://dx.doi.org/10.14227/dt250418p40.

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BHATT, Shailendra, Dabashis ROY, Manish KUMAR, Renu SAHARAN, Anuj MALIK, and Vipin SAINI. "Development and Validation of In Vitro Discriminatory Dissolution Testing Method for Fast Dispersible Tablets of BCS Class II Drug." Turkish Journal of Pharmaceutical Sciences 17, no. 1 (2020): 74–80. http://dx.doi.org/10.4274/tjps.galenos.2018.90582.

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Kollipara, Sivacharan, Adithya Karthik Bhattiprolu, Rajkumar Boddu, Mahendra Chougule, Paramita Saha, and Tausif Ahmed. "Demonstrating Discriminatory Power of a Dissolution Method Using DDDPlus: Case Study of an Extended-Release Formulation and Use in Regulatory Justifications." Dissolution Technologies 31, no. 4 (2024): 174–81. http://dx.doi.org/10.14227/dt310424p174.

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Kumar, Abodh, Muhammad Ramzan Sheikh, and Kashif Saeed. "Weak Institutions and Persistence of Slums in Bihar, India." ANNALS OF SOCIAL SCIENCES AND PERSPECTIVE 2, no. 2 (2021): 157–75. http://dx.doi.org/10.52700/assap.v2i2.57.

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This study endeavours to answer two questions: (a) why do slums persist? and (b) How can we transform slums into better living space? Small city slums have been largely overlooked in the existing literature on urbanization. The study utilises primary data collected from 184 households and focus group discussions conducted in nine different slums of Gaya, a small city of Bihar in India. Econometric results reveal that perceived legal ownership, prolonged stay at the same location, income and education facilitate the dissolution of slum attributes, as defined by UN-Habitat. Our results also sugg

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Dorożyński, Przemyslaw P., Piotr Kulinowski, Aleksander Mendyk, Anna Młynarczyk, and Renata Jachowicz. "Novel Application of MRI Technique Combined with Flow-Through Cell Dissolution Apparatus as Supportive Discriminatory Test for Evaluation of Controlled Release Formulations." AAPS PharmSciTech 11, no. 2 (2010): 588–97. http://dx.doi.org/10.1208/s12249-010-9418-8.

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Purva, Patel*1 Arjun Chaudhari2 Akash Patel1. "Discriminative Dissolution Development and Validation of Poorly Soluble Drugs Using Method Operable Design Region." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 950–65. https://doi.org/10.5281/zenodo.15350900.

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Establishing reliable and discriminative dissolution methods is critical for maintaining the quality and batch consistency of poorly soluble drug formulations—a process often hindered by conventional development techniques. This review emphasizes the transformative benefits of implementing structured Quality by Design (QbD) and Analytical QbD (aQbD) methodologies. By employing Design of Experiments (DoE), a Method Operable Design Region (MODR) can be optimized to guarantee method robustness. Additionally, implementing systematic evaluation protocols—such as defining a Method Discri

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Waiswa, Ekemiya, Asika Winnie, Tuhaire Denis, et al. "Examining the Law Governing Divorce and Sharing of Property in Uganda." IAA JOURNAL OF ART AND HUMANITIES 11, no. 2 (2024): 38–42. http://dx.doi.org/10.59298/iaajah/2024/11.3842.33.

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This article examines the legal framework governing divorce and property distribution in Uganda, revealing that children's rights are often compromised during divorce proceedings. Despite constitutional guarantees ensuring children the right to know and be cared for by their parents, these rights are frequently overlooked. The article advocates for the adoption of a no-fault divorce system, suggesting that the sole ground for divorce should be the irretrievable breakdown of the marriage. This approach would eliminate discriminatory grounds for divorce, focusing instead on the spouses' inabilit

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Warner-Søderholm, Gillian, Giedrė Blažytė, Inga Minelgaite, and Romie Frederick Littrell. "Ethnicity in management studies." Management 27, no. 2 (2022): 41–59. http://dx.doi.org/10.30924/mjcmi.27.2.4.

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Many global changes in the past three decades pose new challenges for contemporary management, including the perception of ethnicity by individuals in different geographic entities. In the European Union (E.U.), Central and Eastern Europe, and Lithuania in particular, ethnicity and social identity are challenged by contemporary political, business, and social life, especially after the dissolution of the USSR and the restoration of independence of nations. The purpose of this study is twofold. First, to provide empirical evidence that issues of ethnicity matter at different levels in an organi

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Purohit, Hitesh S., Niraj S. Trasi, Dajun D. Sun, et al. "Investigating the Impact of Drug Crystallinity in Amorphous Tacrolimus Capsules on Pharmacokinetics and Bioequivalence Using Discriminatory In Vitro Dissolution Testing and Physiologically Based Pharmacokinetic Modeling and Simulation." Journal of Pharmaceutical Sciences 107, no. 5 (2018): 1330–41. http://dx.doi.org/10.1016/j.xphs.2017.12.024.

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Alexiu, Teodor Mircea, Elena-Loreni Baciu, Johans Tveit Sandvin, and Andreea Georgiana Birneanu. "Special or Inclusive Education in Romania?" European Review Of Applied Sociology 9, no. 13 (2016): 15–27. http://dx.doi.org/10.1515/eras-2016-0007.

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AbstractIn our paper we will try to explore the process of reforming the “special needs education” ideology of the Romanian school system toward the European target called “inclusive education”. Following the method of inquiry named Institutional Ethnography, our study investigated first the everyday dysfunctional experiences of special needs populations approaching the scholar system, and then the institutional response for these dysfunctionalities, the final target being a better understanding and finding solutions to the problematics encountered.After the dissolution of the communist regime

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Alimbay, Nursan, Z. Ye Kabyldinov, and B. K. Smagulov. "IIssues of peasant colonization of the Steppe Region in the State Duma of the Russian Empire (1906-1917)." Turkic Studies Journal 5, no. 3 (2023): 7–40. http://dx.doi.org/10.32523/2664-5157-2023-3-7-40.

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The article considers the process of participation of Kazakh deputies of the State Duma (hereinafter – the Duma) of the Russian Empire of the first and second convocations in the discussion and practical solution of the peasant colonization of the Kazakh region, which was aggressive in nature. The novelty of this part of the study is based on the involvement of factual data that had not previously entered scientific circulation, especially official documents of the Duma, it was possible to find out the reasons for the «inferior» participation of Kazakh deputies in the legislative activities of

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Emelina, L. A., and S. A. Yavorsky. "The Role of Fathers in the Upbringing of Children: Legal Responses to Contemporary Challenges." Moscow Juridical Journal, no. 3 (July 14, 2025): 31–41. https://doi.org/10.18384/2949-513x-2024-3-31-41.

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Aim. To analyze the law enforcement practice of determining the place of residence of a child with one of the parents, to study discriminatory aspects in relation to the rights of separated fathers to participate in the upbringing of a child. To propose ways of improving legislative and judicial mechanisms to ensure equal rights of parents and to protect the interests of children.Methodology. The article uses the method of comparative analysis of the norms of Russian family legislation, as well as case law. General scientific methods are applied: analysis, synthesis and abstraction. In additio

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Lozano, Ruben, John M. Joseph, and Berry J. Kline. "Temperature, pH and agitation rate as dissolution test discriminators of zofenopril calcium tablets." Journal of Pharmaceutical and Biomedical Analysis 12, no. 2 (1994): 173–77. http://dx.doi.org/10.1016/0731-7085(94)90027-2.

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Shah, Peer Tehseen, and Sumbal Afridi. "COMPUTER-BASED MEDICAL AND DENTAL COLLEGE ADMISSION TEST (MDCAT) IN PAKISTAN: A REFORM OR COMMOTION?" KHYBER MEDICAL UNIVERSITY JOURNAL 14, no. 4 (2021): 257–8. http://dx.doi.org/10.35845/kmuj.2021.22264.

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In Pakistan, there used to be a separate system of examinations in each province to get admission in Bachelor of Medicine, Bachelor of Surgery (MBBS) and Bachelor of Dental Surgery (BDS).It was a very efficient, transparent, reliable and authentic system unless it was decided to hand-over the task of conducting the exam to a private company called TEPS. In 2019, upon the dissolution of Pakistan medical and dental council (PMDC) and replacing it with Pakistan medical commission (PMC), it was unanimously decided to conduct a centralized examination across the country to provide a level-playing f

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Panda, Ramakant, and Srinivas Lankalapalli. "Development and validation of a discriminatory dissolution method for amorphous solid dispersion formulation of polymorphic Artemether." Research Journal of Pharmacy and Technology, November 30, 2023, 5303–8. http://dx.doi.org/10.52711/0974-360x.2023.00859.

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The aim of this study was to develop and validate one discriminatory dissolution method for evaluation of amorphous solid dispersion of Artemether in its fixed dose combination (FDC) of Artemether lumefantrine tablets. Methods: The evaluation of discriminatory power of the selected dissolution method was based on saturation solubility and sink condition. The impact of addition of surfactant was evaluated in the selected dissolution method comparing the dissolution rate of Artemether from immediate release Artemether and lumefantrine tablets. Comparative dissolution profile of Artemether from c

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Somasekhar, Vanita, Tejashwini H, and Murali krishna PV. "DEVELOPMENT OF A DISCRIMINATORY METHOD FOR DETERMINATION OF IN VITRO DISSOLUTION OF CILNIDIPINE." Asian Journal of Pharmaceutical and Clinical Research, February 7, 2024, 7–9. http://dx.doi.org/10.22159/ajpcr.2024.v17i2.49160.

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Objectives: This study involves the development of a discriminatory method to differentiate the in vitro dissolution of cilnidipine’s mouth-dispersing film from that of a commercial tablet. Methods: The mouth-dispersing film was initially developed using a reported established method. A discriminatory dissolution method was developed to assess the in vitro dissolution of the mouth-dispersing film and compare the same with that of the commercial tablet. Results: The study findings indicated the method employed was able to differentiate the dissolution of the fast-dissolving film from the commer

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SARKAR, PRASENJIT, SAUMYAJYOTI DAS, and SUTAPA BISWAS MAJEE. "BIPHASIC DISSOLUTION MODEL: NOVEL STRATEGY FOR DEVELOPING DISCRIMINATORY IN VIVO PREDICTIVE DISSOLUTION MODEL FOR BCS CLASS II DRUGS." International Journal of Pharmacy and Pharmaceutical Sciences, April 1, 2022, 20–27. http://dx.doi.org/10.22159/ijpps.2022v14i4.44042.

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In vitro dissolution study should ideally be designed to predict in vivo performance precisely, providing key information on the bioavailability and establishing IVIVC. Development of discriminatory in vivo predictive dissolution model and the establishment of IVIVC is difficult to achieve with BCS Class 2 drugs as they exhibit variable absorption along the GI tract owing to pH-dependent solubility, especially for Classes IIa and IIb. In this context, the biphasic dissolution model is a powerful technique for investigating the interplay between dissolution, precipitation and partitioning of va

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Monterroza, Diego R., Claudia M. Baena-Aristizábal, Luisa Fernanda Ponce D´león, and Yolima Baena. "Development of a method to assess the dissolution of soft gelatin capsules containing progesterone in oily suspension." Journal of Applied Pharmaceutical Science, 2024. http://dx.doi.org/10.7324/japs.2024.158285.

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Progesterone is a class II active pharmaceutical ingredient according to the biopharmaceutics classification system, so its absorption is affected by solubility and dissolution rate. The work aimed to develop a dissolution method applicable to soft gelatin capsules of 100 and 200 mg of progesterone. Sink conditions were established based on solubility studies; the dissolution apparatus was selected, and the operational conditions of the method were established using an experimental statistical design. The established conditions were challenged in progesterone products, for which their result w

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Ângelo, Marilene Lopes, André Luís Morais Ruela, Anna Clara Marques Ferreira, et al. "Evaluating the discriminatory power of a dissolution assay for rosuvastatin calcium capsules: Solid-state properties and dissolution media." Brazilian Journal of Pharmaceutical Sciences 55 (2019). http://dx.doi.org/10.1590/s2175-97902019000117520.

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Gupta, Prashant, Dipti H. Patel, Nilesh Dhameliya, Pratik Modh, and Vishvesh Joshi. "A Review on Dissolution Method Development for Drug Products: Current Regulations and Prospects." Research Journal of Pharmaceutical Dosage Forms and Technology, November 9, 2023, 293–302. http://dx.doi.org/10.52711/0975-4377.2023.00047.

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Dissolution (in vitro release) testing has been the subject of intense scientific and regulatory interest over the past several decades. As an analytical methodology, in vitro dissolution testing measures drug release into the dissolution media. The U. S. Food and Drug Administration (USFDA) Dissolution Database was reviewed and screened regarding the type of dosage forms, apparatus type, agitation speed, media volume, and recommended time points for the dissolution profile. The dissolution method requires special laboratory equipment, following a well-defined protocol. Basic information is av

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Rahman, Ziyaur, Eman M. Mohamed, Sathish Dharani, et al. "Development and Validation Of A Discriminatory Dissolution Method for Portioned Moist Snuff and Snus." Journal of Pharmaceutical Sciences, December 2021. http://dx.doi.org/10.1016/j.xphs.2021.11.019.

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RAMIREZ, FELIPE DINO REYES, YAMIR ALI VERA ANGELES, and JOSE RAUL MEDINA LOPEZ. "HYPOTHETICAL IN VIVO BEHAVIOR OF CARBAMAZEPINE TABLETS FROM IN VITRO RELEASE DATA OF USP APPARATUS II AND IV AND DISSOLUTION MEDIA OF PHYSIOLOGICAL RELEVANCE." International Journal of Applied Pharmaceutics, July 7, 2025, 152–58. https://doi.org/10.22159/ijap.2025v17i4.53916.

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Objective: To estimate the hypothetical in vivo behavior of carbamazepine tablets (immediate-release, 200 mg) with dissolution data and a convolutional approach. Methods: USP apparatus II and IV and media at pH 1.2, 4.5, and 6.8 (all containing 1% sodium lauryl sulfate) were used. The dissolved drug was calculated from 10 to 60 min. The dissolution profiles were compared with f2 data and some dissolution parameters. In vitro release data were adjusted using several mathematical models. Predicted plasma levels were calculated using dissolution data and published pharmacokinetic information. A c

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