Bibliographies thématiques / Distal regulatory element

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Littérature scientifique sur le sujet « Distal regulatory element »

Auteur : Grafiati
Publié le 9 mars 2023
Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "Distal regulatory element"

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NEGI, Sarita, Saurabh K. SINGH, Nirupma PATI, Vikas HANDA, Ruchi CHAUHAN, and Uttam PATI. "A proximal tissue-specific module and a distal negative regulatory module control apolipoprotein(a) gene transcription." Biochemical Journal 379, no. 1 (2004): 151–59. http://dx.doi.org/10.1042/bj20030985.

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The apo(a) [apolipoprotein(a)] gene is responsible for variations in plasma lipoprotein(a), high levels of which are a risk factor for atherosclerosis and myocardial infarction. The apo(a) promoter stimulates the expression of reporter genes in HepG2 cells, but not in HeLa cells. In the present study, we demonstrate that the 1.4 kb apo(a) promoter comprises two composite regulatory regions: a distal negative regulatory module (positions −1432 to −716) and a proximal tissue-specific module (−716 to −616). The distal negative regulatory module contains two strong negative regulatory regions [pol
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Herbomel, P., A. Rollier, F. Tronche, M. O. Ott, M. Yaniv, and M. C. Weiss. "The rat albumin promoter is composed of six distinct positive elements within 130 nucleotides." Molecular and Cellular Biology 9, no. 11 (1989): 4750–58. http://dx.doi.org/10.1128/mcb.9.11.4750-4758.1989.

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No fewer than six different positive regulatory elements concentrated within 130 base pairs constitute the rat albumin promoter, which drives highly tissue specific transcription in rat hepatoma cells in culture. Inactivation of each element led to a decrease in transcriptional efficiency: from upstream to downstream, 3- to 4-fold for distal elements III and II, 15-fold for distal element I, and 50-fold for the CCAAT box and the proximal element (PE). Three of these elements, distal elements III and II and, more crucially, the PE, were found to be involved in the tissue-specific character of t
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Herbomel, P., A. Rollier, F. Tronche, M. O. Ott, M. Yaniv, and M. C. Weiss. "The rat albumin promoter is composed of six distinct positive elements within 130 nucleotides." Molecular and Cellular Biology 9, no. 11 (1989): 4750–58. http://dx.doi.org/10.1128/mcb.9.11.4750.

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No fewer than six different positive regulatory elements concentrated within 130 base pairs constitute the rat albumin promoter, which drives highly tissue specific transcription in rat hepatoma cells in culture. Inactivation of each element led to a decrease in transcriptional efficiency: from upstream to downstream, 3- to 4-fold for distal elements III and II, 15-fold for distal element I, and 50-fold for the CCAAT box and the proximal element (PE). Three of these elements, distal elements III and II and, more crucially, the PE, were found to be involved in the tissue-specific character of t
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Collins, Patrick, Melodie Henderson, Shojing Chang, et al. "Distal regions of the human IFNG locus direct cell-type specific expression (88.12)." Journal of Immunology 184, no. 1_Supplement (2010): 88.12. http://dx.doi.org/10.4049/jimmunol.184.supp.88.12.

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Abstract Genes, such as IFNG, which are expressed in multiple cell lineages of the immune system, may employ a common set of regulatory elements to direct transcription in multiple cell types or individual regulatory elements to direct expression in individual cell lineages. By employing a BAC transgenic system, we demonstrate that IFNG employs unique regulatory elements to achieve lineage specific transcriptional control. Specifically, a one 1-kb element 30 kb upstream of IFNG activates transcription in T cells and NKT cells but not NK cells, macrophages and dendritic cells. This distal regul
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Mangnier, Loïc, Charles Joly-Beauparlant, Arnaud Droit, Steve Bilodeau, and Alexandre Bureau. "Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia." Life Science Alliance 5, no. 5 (2022): e202101156. http://dx.doi.org/10.26508/lsa.202101156.

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The 3D conformation of the chromatin creates complex networks of noncoding regulatory regions (distal elements) and promoters impacting gene regulation. Despite the importance of the role of noncoding regions in complex diseases, little is known about their interplay within regulatory hubs and implication in multigenic diseases such as schizophrenia. Here we show that cis-regulatory hubs (CRHs) in neurons highlight functional interactions between distal elements and promoters, providing a model to explain epigenetic mechanisms involved in complex diseases. CRHs represent a new 3D model, where
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Müller, Patrick, Kenneth W. Merrell, Justin D. Crofts, et al. "Estrogen-dependent downregulation of hairy and enhancer of split homolog-1 gene expression in breast cancer cells is mediated via a 3′ distal element." Journal of Endocrinology 200, no. 3 (2008): 311–19. http://dx.doi.org/10.1677/joe-08-0094.

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Regulation of hairy and enhancer of split homologue-1 (HES-1) by estradiol and all-trans retinoic acid affects proliferation of human breast cancer cells. Here, we identify and characterize cis-regulatory elements involved in HES-1 regulation. In the distal 5′ promoter of the HES-1 gene, we found a retinoic acid response element and in the distal 3′ region, an estrogen receptor α(ER)α binding site. The ERα binding site, composed of an estrogen response element (ERE) and an ERE half-site, is important for both ERα binding and transcriptional regulation. Chromatin immunoprecipitation assays reve
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Tsika, Richard W., John McCarthy, Natalia Karasseva, Yangsi Ou та Gretchen L. Tsika. "Divergence in species and regulatory role of β-myosin heavy chain proximal promoter muscle-CAT elements". American Journal of Physiology-Cell Physiology 283, № 6 (2002): C1761—C1775. http://dx.doi.org/10.1152/ajpcell.00278.2002.

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We examined the functional role of distinct muscle-CAT (MCAT) elements during non-weight-bearing (NWB) regulation of a wild-type 293-base pair β-myosin heavy chain (βMyHC) transgene. Electrophoretic mobility shift assays (EMSA) revealed decreased NTEF-1, poly(ADP-ribose) polymerase, and Max binding at the human distal MCAT element when using NWB soleus vs. control soleus nuclear extract. Compared with the wild-type transgene, expression assays revealed that distal MCAT element mutation decreased basal transgene expression, which was decreased further in response to NWB. EMSA analysis of the hu
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Li, Youlin, Yutaka Okuno, Pu Zhang, et al. "Regulation of the PU.1 gene by distal elements." Blood 98, no. 10 (2001): 2958–65. http://dx.doi.org/10.1182/blood.v98.10.2958.

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Abstract The transcription factor PU.1 (also known as Spi-1) plays a critical role in the development of the myeloid lineages, and myeloid cells derived from PU.1−/− animals are blocked at the earliest stage of myeloid differentiation. Expression of the PU.1 gene is tightly regulated during normal hematopoietic development, and dysregulation of PU.1 expression can lead to erythroleukemia. However, relatively little is known about how the PU.1 gene is regulated in vivo. Here it is shown that myeloid cell type–specific expression of PU.1 in stable cell lines and transgenic animals is conferred b
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Tapscott, S. J., A. B. Lassar, and H. Weintraub. "A novel myoblast enhancer element mediates MyoD transcription." Molecular and Cellular Biology 12, no. 11 (1992): 4994–5003. http://dx.doi.org/10.1128/mcb.12.11.4994-5003.1992.

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The MyoD gene can orchestrate the expression of the skeletal muscle differentiation program. We have identified the regions of the gene necessary to reproduce transcription specific to skeletal myoblasts and myotubes. A proximal regulatory region (PRR) contains a conserved TATA box, a CCAAT box, and a GC-rich region that includes a consensus SP1 binding site. The PRR is sufficient for high levels of skeletal muscle-specific activity in avian muscle cells. In murine cells the PRR alone has only low levels of activity and requires an additional distal regulatory region to achieve high levels of
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Tapscott, S. J., A. B. Lassar, and H. Weintraub. "A novel myoblast enhancer element mediates MyoD transcription." Molecular and Cellular Biology 12, no. 11 (1992): 4994–5003. http://dx.doi.org/10.1128/mcb.12.11.4994.

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The MyoD gene can orchestrate the expression of the skeletal muscle differentiation program. We have identified the regions of the gene necessary to reproduce transcription specific to skeletal myoblasts and myotubes. A proximal regulatory region (PRR) contains a conserved TATA box, a CCAAT box, and a GC-rich region that includes a consensus SP1 binding site. The PRR is sufficient for high levels of skeletal muscle-specific activity in avian muscle cells. In murine cells the PRR alone has only low levels of activity and requires an additional distal regulatory region to achieve high levels of
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Thèses sur le sujet "Distal regulatory element"

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BERTOLINI, JESSICA ARMIDA. "Functional characterization of regulatory sequences targeted by the transcription factor SOX2, identified by studies of long-range chromatin interactions in brain-derived neural stem/precursor cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/83922.

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Sox2 codifica per un fattore trascrizionale necessario per la pluripotenza delle cellule staminali embrionali. Mutazioni eterozigoti in Sox2 nell’uomo causano difetti nello sviluppo dell’occhio (anoftalmia, microftalmia) e dell’ippocampo, con insorgenza di patologie come epilessia, problemi nel controllo motorio e difetti di apprendimento. Tramite “knock-out” condizionale di Sox2 in topo, abbiamo osservato l’importanza di Sox2 per lo sviluppo del cervello e per il “self-renewal” delle staminali neurali. Di recente è emerso che elementi regolatori possono trovarsi molto lontano dai geni che
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Mitchelmore, Joanna. "Investigation of transcription factor binding at distal regulatory elements." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277805.

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Cellular development and function necessitate precise patterns of gene expression. Control of gene expression is in part orchestrated by a class of remote regulatory elements, termed enhancers, which are brought into contact with promoters via DNA looping. Enhancers typically contain clusters of transcription factor binding sites, and TF recruitment to them is thought to play a key role in transcriptional control. In this thesis I have addressed two issues regarding gene regulation by enhancers. First, with recent genome-wide enhancer mapping, it is becoming increasingly apparent that genes ar
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Schoenborn, Jamie R. "Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing Ifng transcription /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5098.

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Zhang, Wei, and 张伟. "Characterization of distal and proximal regulatory elements of the human neuroglobin gene." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47147568.

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Zerucha, Ted. "Evolution of auto- and cross-regulatory elements of members of the distal-less-related family of homeobox-containing genes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0017/NQ45202.pdf.

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Hamdan, Feda Hisham Moh'd [Verfasser], Steven [Akademischer Betreuer] Johnsen, Steven [Gutachter] Johnsen, et al. "Role of Distal Regulatory Elements in Cancer Progression and Therapy / Feda Hisham Moh'd Hamdan ; Gutachter: Steven Johnsen, Matthias Dobbelstein, Heidi Hahn, Nico Posnien, Ufuk Günesdogan, Volker Ellenrieder ; Betreuer: Steven Johnsen." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1203218915/34.

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Hamdan, Feda Hisham Moh'd. "Role of Distal Regulatory Elements in Cancer Progression and Therapy." Doctoral thesis, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E556-A.

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Chapitres de livres sur le sujet "Distal regulatory element"

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Karasu, Nezih, and Tom Sexton. "Assessment of 3D Interactions Between Promoters and Distal Regulatory Elements with Promoter Capture Hi-C (PCHi-C)." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1597-3_13.

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Revington, M. J., and W. Lee. "Heteronuclear Strategies for the Assignment of Larger protein/DNA complexes: Application to the 37 kDa trp Represser-Operator Complex." In Biological NMR Spectroscopy. Oxford University Press, 1997. http://dx.doi.org/10.1093/oso/9780195094688.003.0012.

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The sequence-specific DNA binding function of many proteins is recognized as one of the central mechanisms of regulating transcription and DNA replication and repair. The ability of these proteins to select a short (usually 10 to 20 basepair) sequence out of the entire genome with which to form a stable complex is a prime example of molecular recognition. Atomic resolution structural studies using NMR and X-ray crystallography have emerged as essential techniques in understanding the basis of specificity and stability in these systems. While NMR studies of small DNA-binding domains of proteins
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Actes de conférences sur le sujet "Distal regulatory element"

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Jeon, Myeongjune. "Distal Regulatory Element of FLOWERING LOCUS C Allows Plants to Distinguish Different Types of Cold." In ASPB PLANT BIOLOGY 2020. ASPB, 2020. http://dx.doi.org/10.46678/pb.20.399365.

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Okano, Larissa Miyuki, Alexandre Luiz Korte de Azevedo, Tamyres Mingorance Carvalho, Tathiane Maistro Malta, Mauro Antonio Alves Castro, and Luciane Regina Cavalli. "Characterization of an epigenetic regulatory network on basal-like breast cancer subtype and its impact on signaling pathways and biological processes." In Brazilian Breast Cancer Symposium 2024. Mastology, 2024. http://dx.doi.org/10.29289/259453942024v34s1029.

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Objective: The main objective of this study was to identify DNA methylation at the distal cis-regulatory genomic regions associated with the basal-like breast cancer (BLBC) subtype, construct an epigenetic regulatory network, and determine its impact on cancer-associated signaling pathways and biological processes. Methodology: BLBC (n=134) and non- -tumoral breast (n=84) samples with DNA methylation, mRNA, and miRNA expression data were downloaded from The Cancer Genome Atlas (TCGA) database using a pipeline of computational tools. DNA methylation patterns on cancer- -specific enhancers enric
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Teng, Li, and Kai Tan. "Discovering distal regulatory elements by integrating multiple types of chromatin state maps." In 2012 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2012. http://dx.doi.org/10.1109/bibm.2012.6392628.

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Kelly, Rose, Creason, C. Gabriel, Mark-Moser MacKenzie, et al. "The Co-Saline Storage Method: Advanced Modeling to Accelerate Offshore CCS." In Offshore Technology Conference. OTC, 2024. http://dx.doi.org/10.4043/35052-ms.

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Abstract Offshore locations present significant potential for geologic carbon storage (GCS). Key differences and benefits over onshore GCS include locations distal from population centers and abundant, high-quality reservoirs. Yet, offshore GCS projects also face major logistical challenges, such as metocean conditions and more costly operations. Co-saline storage is a proposed concept to defray costs and risks to candidate offshore GCS operations, while leveraging advanced U.S. Department of Energy (DOE), peer-reviewed models to support and expedite implementation. Assessing for co-saline sto
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