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Articles de revues sur le sujet « Dysplastic neoplasia »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Neves, André, Massimiliano Di Pietro, Maria O’Donovan, et al. "Detection of early neoplasia in Barrett’s esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue." Endoscopy 50, no. 06 (2018): 618–25. http://dx.doi.org/10.1055/s-0043-124080.

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Abstract Background and study aims Endoscopic surveillance for Barrett’s esophagus (BE) is limited by long procedure times and sampling error. Near-infrared (NIR) fluorescence imaging minimizes tissue autofluorescence and optical scattering. We assessed the feasibility of a topically applied NIR dye-labeled lectin for the detection of early neoplasia in BE in an ex vivo setting. Methods Consecutive patients undergoing endoscopic mucosal resection (EMR) for BE-related early neoplasia were recruited. Freshly collected EMR specimens were sprayed at the bedside with fluorescent lectin and then ima

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Rickelt, Steffen, Azfar Neyaz, Charlene Condon, et al. "Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker." Clinical Cancer Research 28, no. 6 (2022): 1167–79. http://dx.doi.org/10.1158/1078-0432.ccr-21-2822.

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Abstract Purpose: There is an unmet need for identifying novel biomarkers in Barrett's esophagus that could stratify patients with regards to neoplastic progression. We investigate the expression patterns of extracellular matrix (ECM) molecules in Barrett's esophagus and Barrett's esophagus–related neoplasia, and assess their value as biomarkers for the diagnosis of Barrett's esophagus–related neoplasia and to predict neoplastic progression. Experimental Design: Gene-expression analyses of ECM matrisome gene sets were performed using publicly available data on human Barrett's esophagus, Barret

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Carballal, Sabela, Sandra Maisterra, Antonio López-Serrano, et al. "Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD." Gut 67, no. 1 (2016): 70–78. http://dx.doi.org/10.1136/gutjnl-2016-312332.

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ObjectiveOutside clinical trials, the effectiveness of chromoendoscopy (CE) for long-standing IBD surveillance is controversial. We aimed to assess the effectiveness of CE for neoplasia detection and characterisation, in real-life.DesignFrom June 2012 to 2014, patients with IBD were prospectively included in a multicentre cohort study. Each colonic segment was evaluated with white light followed by 0.4% indigo carmine CE. Specific lesions' features were recorded. Optical diagnosis was assessed. Dysplasia detection rate between expert and non-expert endoscopists and learning curve were ascertai

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KAPETANIOS, V., A. C. LAZARIS, P. BOGRIS, et al. "Extracellular regulated kinase-2 immunoreactivity increases in parallel with cervical intraepithelial neoplasia grade in cervical neoplasia." International Journal of Gynecologic Cancer 18, no. 3 (2008): 540–45. http://dx.doi.org/10.1111/j.1525-1438.2007.01057.x.

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The cell cycle control system includes cyclins, cyclin-dependent kinases (CDK), and their inhibitors (CDK1). Extracellular regulated kinase (ERK1/2) (p44 and p42 mitogen-activated protein kinases [MAPKs]) is a component of the MAPK pathway, which is associated with cyclin D1 and CDK. It is a critical signaling system for the induction of cell proliferation, differentiation, and cell survival. The aim of this study was to investigate the usefulness of ERK2 expression as a marker of biological aggressiveness complementary to cervical intraepithelial neoplasia (CIN) grade as well as to compare it

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Beggs, Andrew D., Jonathan James, Germaine Caldwell, et al. "Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia." Inflammatory Bowel Diseases 24, no. 7 (2018): 1503–9. http://dx.doi.org/10.1093/ibd/izy119.

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Abstract Background and aims Ulcerative colitis (UC) is associated with a higher background risk of dysplasia and/or neoplasia due to chronic inflammation. There exist few biomarkers for identification of patients with dysplasia, and targeted biopsies in this group of patients are inaccurate in reliably identifying dysplasia. We aimed to examine the epigenome of UC dysplasia and to identify and validate potential biomarkers Methods Colonic samples from patients with UC-associated dysplasia or neoplasia underwent epigenome-wide analysis on the Illumina 450K methylation array. Markers were valid

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Tariq, Raseen, Sarah Enslin, Maham Hayat, and Vivek Kaul. "Efficacy of Cryotherapy as a Primary Endoscopic Ablation Modality for Dysplastic Barrett’s Esophagus and Early Esophageal Neoplasia: A Systematic Review and Meta-Analysis." Cancer Control 27, no. 1 (2020): 107327482097666. http://dx.doi.org/10.1177/1073274820976668.

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Introduction: Cryotherapy is a cold-based ablative therapy used primarily as second line therapy in patients with Barrett’s esophagus (BE) who have persistent dysplasia after undergoing endoscopic treatment with radiofrequency ablation (RFA). Few studies have described the use of cryotherapy as a primary treatment modality for dysplastic or neoplastic BE. Aim: To evaluate the efficacy of cryotherapy as primary treatment of dysplastic and/or neoplastic BE by conducting a systemic review and meta-analysis. Methods: A systematic search of Medline, Embase, and Web of Science was performed from Jan

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Claessen, Marian M. H., Marguerite E. I. Schipper, Bas Oldenburg, Peter D. Siersema, G. Johan A. Offerhaus, and Frank P. Vleggaar. "WNT-Pathway Activation in IBD-Associated Colorectal Carcinogenesis: Potential Biomarkers for Colonic Surveillance." Analytical Cellular Pathology 32, no. 4 (2010): 303–10. http://dx.doi.org/10.1155/2010/957698.

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Objectives: The Wnt-pathway dominates the sporadic carcinogenesis whereas p53 plays a pivotal role in the colitis-associated counterpart. The expression of Wnt-signaling proteins and p53 during colitis-associated carcinogenesis was determined.Methods: A tissue microarray was constructed with colonic samples from 5 groups of patients: controls (C, n=10), IBD without neoplasia (IBD, n=12), non-dysplastic IBD with neoplasia elsewhere in the colon (IBD-NE, n=12), dysplastic lesion in IBD (IBD-DYS, n=12), and IBD-associated colorectal cancer (IBD-CRC, n=10). Immunohistochemistry was performed for β

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Saiz Chumillas, R. M., L. Alba, Y. Gonzalez-Lama, et al. "P122 Low Risk of new dysplastic lesions during inflammatory bowel disease surveillance with dye-cromoendoscopy: a multicenter population-based retrospective study." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i211—i213. http://dx.doi.org/10.1093/ecco-jcc/jjab232.250.

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Abstract Background The 21st century has witnessed advances in endoscopic surveillance technology such as high-definition imaging and virtual or dye-based chromoendoscopy, which have led to increased detection of dysplasia. It is unknown the rates of new dysplastic lesions or cancer progression with these techniques though it seems lower than previously described. Methods We developed a multicenter, population-based and retrospective cohort from 7 Spanish hospitals from the Group of Inflammatory bowel disease of Castilla Y Leon (GEICYL) including sequentially all patients with inflammatory bow

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Huang, Lee-Wen, Hun-Shan Pan, Yu-Hung Lin, Kok-Min Seow, Heng-Ju Chen, and Jiann-Loung Hwang. "P16 Methylation Is an Early Event in Cervical Carcinogenesis." International Journal of Gynecologic Cancer 21, no. 3 (2011): 452–56. http://dx.doi.org/10.1097/igc.0b013e31821091ea.

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BackgroundAberrant gene promoter methylation is a critical event in tumorigenesis. The aim of this study was to explore the promoter hypermethylation of p16 and DAPK1 during the progression of cervical precancerous lesions.MethodsA series of 98 cervical neoplasms (72 cervical intraepithelial neoplasia and 26 cervical carcinomas) were evaluated. The promoter methylation status of p16 and DAPK1 was assessed from cervical scrapings by methylation-specific polymerase chain reaction.ResultsFor p16, the frequency of promoter hypermethylation showed an increasing trend from normal to dysplastic to in

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Farhat, Nada, Nora Laver, and José Caro. "9. Cellular immune response to anal dysplasia in HIV-positive men on highly active antiretroviral therapy." Sexual Health 10, no. 6 (2013): 574. http://dx.doi.org/10.1071/shv10n6ab9.

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Background The role of the cellular immune response to anal dysplasia progression is poorly understood. Extrapolated from the cervical model, CD4+ (killed by HIV) and CD8+ cells may have crucial anti-tumour activity. We report pilot data on key immune responses in HIV+ patients on HAART with anal dysplasia. Methods: High-resolution anoscopy and biopsies were performed. Ten tissue biopsies with high-grade anal intraepithelial neoplasia (HGAIN) were stained with immunohistochemistry for CD4+, CD8+, CXCL12+ and FOXP3+, and compared with 10 samples with low-grade anal intraepithelial neoplasia (LG

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Nobre, Aretha Brito, Juan Piñeiro-Maceira, and Ronir Raggio Luiz. "Analysis of interobserver reproducibility in grading histological patterns of dysplastic nevi*." Anais Brasileiros de Dermatologia 88, no. 1 (2013): 23–31. http://dx.doi.org/10.1590/s0365-05962013000100002.

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BACKGROUND: Dysplastic nevi are among the most important cutaneous melanoma simulators. They are important risk markers for this neoplasia and can be its potential precursors. Some authors found a statistically significant relationship between the degree of dysplasia and the risk for developing melanoma. However, reproducibility of grading criteria ranged from poor to fair in the researched articles. OBJECTIVE: To test the reproducibility of the grading criteria proposed by Sagebiel et al. regarding dysplastic nevi. METHODS: Histological specimens of 75 dysplastic nevi were graded, independent

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Uno, Kaname, Tomoyuki Koike, Waku Hatta, Masahiro Saito, Mizuki Tanabe, and Atsushi Masamune. "Development of Advanced Imaging and Molecular Imaging for Barrett’s Neoplasia." Diagnostics 12, no. 10 (2022): 2437. http://dx.doi.org/10.3390/diagnostics12102437.

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Barrett esophagus (BE) is a precursor to a life-threatening esophageal adenocarcinoma (EAC). Surveillance endoscopy with random biopsies is recommended for early intervention against EAC, but its adherence in the clinical setting is poor. Dysplastic lesions with flat architecture and patchy distribution in BE are hardly detected by high-resolution endoscopy, and the surveillance protocol entails issues of time and labor and suboptimal interobserver agreement for diagnosing dysplasia. Therefore, the development of advanced imaging technologies is necessary for Barrett’s surveillance. Recently,

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Watson, Thomas J. "What If Endoscopic Eradication Therapy for Esophageal Neoplasia Is Not Good Enough?" Foregut: The Journal of the American Foregut Society 2, no. 2 (2022): 116–22. http://dx.doi.org/10.1177/26345161221116367.

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Endoscopic eradication therapies have become the standard of care for most cases of Barrett’s esophagus with high-grade dysplasia or intramucosal adenocarcinoma, largely replacing esophagectomy. While associated with high rates of complete elimination of dysplastic mucosa and superficially invasive esophageal cancer, as well as an excellent complication profile, endoscopic eradication requires strict adherence to established diagnostic and treatment protocols as well as disciplined follow-up. Even with appropriate attention to detail, esophageal neoplasia can persist or recur following endosco

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Fragoso, Mariana F., Geysson J. Fernandez, Lisa Vanderveer, Harry S. Cooper, Michael Slifker, and Margie L. Clapper. "Dysregulation of miR-1-3p: An Early Event in Colitis-Associated Dysplasia." International Journal of Molecular Sciences 23, no. 21 (2022): 13024. http://dx.doi.org/10.3390/ijms232113024.

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Detection of colorectal dysplasia during surveillance colonoscopy remains the best method of determining risk for colitis-associated colorectal cancer (CAC). miRNAs (miRs) show great promise as tissue-specific biomarkers of neoplasia. The goal of this study was to explore the miR expression profile of precancerous dysplastic lesions in the AOM/DSS mouse model and identify early molecular changes associated with CAC. Epithelial cells were laser-microdissected from the colonic mucosa (inflamed versus dysplastic) of mice with AOM/DSS-induced colitis. A miR signature that can distinguish inflamed

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Dhaliwal, Lovekirat, and Prasad G. Iyer. "State of the Art: Management of Barrett’s Esophagus Related Dysplasia and Neoplasia—Which Patient and What Therapy?" Foregut: The Journal of the American Foregut Society 1, no. 1 (2021): 68–77. http://dx.doi.org/10.1177/2634516121993260.

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Endoscopic eradication therapy (EET) is safe and effective in the management of Barrett’s esophagus (BE) related dysplasia and early adenocarcinoma. EET includes endoscopic resection of the visible lesions followed by ablation to eradicate the residual Barrett’s epithelium. Techniques available for endoscopic resection include cap-based endoscopic mucosal resection and endoscopic submucosal dissection. Ablative therapies such as RFA, cryoablation and APC are used for the eradication of dysplastic BE and to prevent progression to EAC. Complete remission of intestinal metaplasia is the goal of E

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Kondratyuk, V. K., T. D. Zadorozhnaya, A. I. Narolskaya, N. Ye Gorban, P. N. Botsyun, and O. I. Pustovalova. "Diagnostic treatment approach for cervical intraepithelial neoplasia in women of reproductive age with benign uterine hyperplasia." HEALTH OF WOMAN, no. 7(113) (September 30, 2016): 121–24. http://dx.doi.org/10.15574/hw.2016.113.121.

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The article presents an analysis of the complex treatment results of reproductive age patients with uterine leiomyoma and dysplastic lesions of the squamous epithelium of the cervix which included anti-inflammatory therapy and radiowave surgery. The use of complex therapeutic measures in patients with uterine leiomyoma and dysplastic lesions of the squamous epithelium of the cervix allowed to reduce the epithelialization period of postoperative wound surface and to decrease the incidence of complications and recurrences. Key words: uterine leiomyoma, dysplastic lesions of squamous epithelium,

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Lyons, Keegan, and Samantha Butler. "Anal Intraepithelial Neoplasia from a Pathologists Point of View." Clinics in Colon and Rectal Surgery 31, no. 06 (2018): 328–35. http://dx.doi.org/10.1055/s-0038-1668102.

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AbstractAnal squamous cell carcinoma is a relatively rare diagnosis, but its incidence has continued to rise. Anal squamous cell carcinoma and its precursor lesion, anal intraepithelial neoplasia (AIN), are human papillomavirus (HPV)-associated squamous neoplasias. High-risk HPV subtypes cause cellular proliferation in the anal transformation zone mucosa leading to similar dysplastic changes as seen in the cervix. Unified cytologic and histologic classification systems have emerged for all HPV-associated squamous lesions of the lower anogenital tract due to recent advancements in the understan

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Toiyama, Yuji, Keun Hur, Koji Tanaka, et al. "Methylated miR-124, -137, and -34b/c as predictive biomarkers for ulcerative colitis-associated colorectal neoplasia." Journal of Clinical Oncology 31, no. 15_suppl (2013): e14631-e14631. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e14631.

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e14631 Background: Accumulating evidence suggests that microRNAs (miRNAs) can be targets of methylation-induced silencing in colorectal cancer, which can occur in an age-dependent manner, and constitutes an epigenetic “field defect”. We hypothesized whether methylation of miR-124, -137 and -34b/c can predict colorectal neoplasia in patients with ulcerative colitis (UC). Methods: We examined 185 samples from 70 UC patients (45 patients without neoplasia, 12 with dysplasia and 13 with cancers) for the methylation status of miR-124, -137 and -34b/c by quantitative bisulfite pyrosequencing analysi

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Spiceland, Clayton M., B. Joseph Elmunzer, Samuel Paros, et al. "Salvage cryotherapy in patients undergoing endoscopic eradication therapy for complicated Barrett’s esophagus." Endoscopy International Open 07, no. 07 (2019): E904—E911. http://dx.doi.org/10.1055/a-0902-4587.

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Abstract Background and study aims Some patients with dysplastic Barrett’s esophagus (BE) experience suboptimal response to radiofrequency ablation (RFA), endoscopic mucosal resection (EMR), or the combination. Cryotherapy has been used as salvage therapy in these patients, but outcomes data are limited. We aimed to assess clinical outcomes among a large cohort of patients with dysplastic BE whose condition had failed to respond to RFA and/or EMR. Patients and methods This was a retrospective cohort study of consecutive cases of dysplastic BE or intramucosal carcinoma (IMC) treated with salvag

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Elsadek, Hany M., and Mamdouh M. Radwan. "Diagnostic Accuracy of Mucosal Biopsy versus Endoscopic Mucosal Resection in Barrett’s Esophagus and Related Superficial Lesions." International Scholarly Research Notices 2015 (January 29, 2015): 1–6. http://dx.doi.org/10.1155/2015/735807.

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Background. Endoscopic surveillance for early detection of dysplastic or neoplastic changes in patients with Barrett's esophagus (BE) depends usually on biopsy. The diagnostic and therapeutic role of endoscopic mucosal resection (EMR) in BE is rapidly growing. Objective. The aim of this study was to check the accuracy of biopsy for precise histopathologic diagnosis of dysplasia and neoplasia, compared to EMR in patients having BE and related superficial esophageal lesions. Methods. A total of 48 patients with previously diagnosed BE (36 men, 12 women, mean age 49.75±13.3 years) underwent routi

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Shrestha, Poonam, and Mukesh Pandey. "Giant Ocular Surface Squamous Neoplasia Wrapping Almost the Whole Cornea: A Case Report." Journal of Institute of Medicine Nepal 42, no. 2 (2020): 94–96. http://dx.doi.org/10.3126/jiom.v42i2.37548.

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Ocular surface squamous neoplasia (OSSN) includes the dysplastic lesions involving the epithelium of conjunctiva and cornea with various clinical pictures. Histopathological examination of the excised tissue is the benchmark for diagnosis. Surgery, chemotherapy, immunotherapy are the various treatment modalities which in combination shows promising result. We present here a case of 83 years old female patient with history of fleshy mass covering the cornea and the patient was diagnosed clinically as ocular surface squamous neoplasia. Patient underwent surgical excision of the mass followed by

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Shrestha, Poonam, and Mukesh Pandey. "Giant Ocular Surface Squamous Neoplasia Wrapping Almost the Whole Cornea: A Case Report." Journal of Institute of Medicine Nepal 42, no. 2 (2020): 94–96. http://dx.doi.org/10.59779/jiomnepal.1120.

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Ocular surface squamous neoplasia (OSSN) includes the dysplastic lesions involving the epithelium of conjunctiva and cornea with various clinical pictures. Histopathological examination of the excised tissue is the benchmark for diagnosis. Surgery, chemotherapy, immunotherapy are the various treatment modalities which in combination shows promising result. We present here a case of 83 years old female patient with history of fleshy mass covering the cornea and the patient was diagnosed clinically as ocular surface squamous neoplasia. Patient underwent surgical excision of the mass followed by

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Brand, Randall, Sumera Rizvi, Jon M. Davison, et al. "Use of optical biomarkers from nondysplastic metaplastic cells on the detection of high-grade dysplasia and adenocarcinoma from Barrett’s esophagus." Journal of Clinical Oncology 30, no. 4_suppl (2012): 14. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.14.

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14 Background: Patients with Barrett’s esophagus (BE), defined as presence of intestinal metaplasia (IM) in the esophagus, require surveillance due to an increased risk of developing esophageal adenocarcinoma (EAC). The biggest challenge in the current surveillance methodology (i.e., Seattle protocol) is random sampling with the inability to identify those patients with non-dysplastic BE on surveillance who have occult high grade dysplasia (HGD) or will eventually progress to HGD or EAC. We propose a novel approach based on the concept of field effect to detect HGD or EAC through the analysis

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Boeriu, Alina, Olga Brusnic, Danusia Onișor, Ofelia Pascarenco, C. Boeriu, and Daniela Dobru. "The usefulness of white light endoscopy, narrow band imaging, and magnification for the optimization of diagnosis in Barrett’s esophagus." Acta Medica Marisiensis 60, no. 6 (2014): 244–48. http://dx.doi.org/10.1515/amma-2015-0002.

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Abstract The diagnosis of dysplasia and early neoplasia in Barrett’s esophagus by conventional endoscopy is based on a four- quadrant random biopsies protocol that is prone to sampling errors. Novel endoscopic techniques have been developed to enhance the detection of premalignant and malignant lesions by real time assessment of microvasculare architecture and mucosal structure. Chromoendoscopy with magnification has improved the visualization of lesions, but the dye application impairs a clear evaluation of vascular network. Narrow band imaging endoscopy enhances vascular imaging by using nar

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Steger, Bernhard. "Ocular surface angiography: from neovessels to neoplasia." BMJ Open Ophthalmology 6, no. 1 (2021): e000829. http://dx.doi.org/10.1136/bmjophth-2021-000829.

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The ocular surface vascular system plays a key role in corneal and conjunctival inflammatory, infectious and neoplastic pathology. Angiographic vessel analysis using intravenous dyes and optical coherence tomography technology allow both the quantitative and functional assessment of conjunctival vasculature and corneal neovessels. Based on a thorough understanding of vascular alterations in ocular surface disease, angiographic assessment facilitates the clinical management of corneal neovascularisation, the grading of ocular surface inflammation and the identification of tumour angiogenesis in

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Gupta, Urvashi, Ruchi Shrestha, Ashok P. Samdurkar, and Anita Shahi. "A Histopathological Study of Neoplastic Lesions of Conjunctiva." Journal of Universal College of Medical Sciences 4, no. 1 (2018): 32–35. http://dx.doi.org/10.3126/jucms.v4i1.19077.

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BACKGROUND: Ocular malignant tumors are relatively rare compared to other eye lesions, require immediate diagnosis and management. But ignorant care due to unawareness of persons can result into debility, loss of vision, and occasionally life is jeopardized.1 The aim of the study is to determine the frequency of most common neoplastc lesions of conjunctiva with histopathologically confirmed diagnosis. MATERIAL AND METHODS: It was a retrospective cross-sectional study done in a period of two years (January 2011 December 2012) that included120 patients who presented with conjunctival lesions to

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Nealis, Thomas B., Kay Washington, and Rajesh N. Keswani. "Endoscopic Therapy of Esophageal Premalignancy and Early Malignancy." Journal of the National Comprehensive Cancer Network 9, no. 8 (2011): 890–99. http://dx.doi.org/10.6004/jnccn.2011.0073.

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Esophageal adenocarcinoma (EAC) is an often deadly cancer with a rising incidence in Western countries. Chronic gastroesophageal reflux disease is associated with the metaplastic transformation of normal squamous epithelium to premalignant specialized intestinal metaplasia within the esophagus (Barrett's esophagus). Barrett's esophagus may progress to low-grade dysplasia (LGD), high-grade dysplasia (HGD), or even EAC. Although nondysplastic Barrett's esophagus progresses to EAC at a rate of 0.5% per year, rates of progression for true LGD and HGD are significantly higher. Treatment is mandator

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Goda, Kenichi, Manabu Takeuchi, Ryu Ishihara, et al. "Diagnostic utility of a novel magnifying endoscopic classification system for superficial Barrett’s esophagus-related neoplasms: a nationwide multicenter study." Esophagus 18, no. 4 (2021): 713–23. http://dx.doi.org/10.1007/s10388-021-00841-1.

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Abstract Background Currently, no classification system using magnification endoscopy for the diagnosis of superficial Barrett’s esophagus (BE)-related neoplasia has been widely accepted. This nationwide multicenter study aimed to validate the diagnostic accuracy and reproducibility of the magnification endoscopy classification system, including the diagnostic flowchart developed by the Japan Esophageal Society—Barrett’s esophagus working group (JES-BE) for superficial Barrett’s esophagus-related neoplasms. Methods The JES-BE acquired high-definition magnification narrow-band imaging (HM-NBI)

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Wils, Leon J., Jos B. Poell, Ilkay Evren, et al. "Incorporation of differentiated dysplasia improves prediction of oral leukoplakia at increased risk of malignant progression." Modern Pathology 33, no. 6 (2020): 1033–40. http://dx.doi.org/10.1038/s41379-019-0444-0.

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AbstractOral leukoplakia is the most common oral potentially malignant disorder with a malignant transformation rate into oral squamous cell carcinoma of 1–3% annually. The presence and grade of World Health Organization defined dysplasia is an important histological marker to assess the risk for malignant transformation, but is not sufficiently accurate to personalize treatment and surveillance. Differentiated dysplasia, known from differentiated vulvar intraepithelial neoplasia, is hitherto not used in oral dysplasia grading. We hypothesized that assessing differentiated dysplasia besides Wo

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Luigiano, Carmelo, Giuseppe Iabichino, Leonardo Henry Eusebi, et al. "Outcomes of Radiofrequency Ablation for Dysplastic Barrett’s Esophagus: A Comprehensive Review." Gastroenterology Research and Practice 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/4249510.

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Barrett’s esophagus is a condition in which the normal squamous lining of the esophagus has been replaced by columnar epithelium containing intestinal metaplasia induced by recurrent mucosal injury related to gastroesophageal reflux disease. Barrett’s esophagus is a premalignant condition that can progress through a dysplasia-carcinoma sequence to esophageal adenocarcinoma. Multiple endoscopic ablative techniques have been developed with the goal of eradicating Barrett’s esophagus and preventing neoplastic progression to esophageal adenocarcinoma. For patients with high-grade dysplasia or intr

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Wong, Clarence K., Kurian Joseph, and Simon R. Turner. "Treatment Options for Patients With Persistent Disease After Initial Endotherapy for Esophageal Neoplasia." Foregut: The Journal of the American Foregut Society 2, no. 2 (2022): 123–31. http://dx.doi.org/10.1177/26345161221115360.

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There are numerous treatment options for esophageal dysplasia and neoplasia. Initial endoscopic therapy is the standard of care for high-risk lesions of the esophagus. However, residual and recurrent disease may be seen after initial endoscopic treatment, and selection of the optimal salvage treatment may be critical in achieving cure. Patients may be high risk for esophagectomy after assessment of risk factors such as age, frailty, and nutritional status. A wide array of salvage endoscopic eradication therapies may also be available, but consideration should be given to the initial endoscopic

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Bergin, I. L., J. D. Bell, Z. Chen, et al. "Novel Genital Alphapapillomaviruses in Baboons (Papio hamadryas Anubis) With Cervical Dysplasia." Veterinary Pathology 50, no. 1 (2012): 200–208. http://dx.doi.org/10.1177/0300985812439725.

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Genital Alphapapillomavirus (αPV) infections are one of the most common sexually transmitted human infections worldwide. Women infected with the highly oncogenic genital human papillomavirus (HPV) types 16 and 18 are at high risk for development of cervical cancer. Related oncogenic αPVs exist in rhesus and cynomolgus macaques. Here the authors identified 3 novel genital αPV types (PhPV1, PhPV2, PhPV3) by PCR in cervical samples from 6 of 15 (40%) wild-caught female Kenyan olive baboons ( Papio hamadryas anubis). Eleven baboons had koilocytes in the cervix and vagina. Three baboons had dysplas

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Rouphael, Carol, Mythri Anil Kumar, Madhusudhan R. Sanaka, and Prashanthi N. Thota. "Indications, contraindications and limitations of endoscopic therapy for Barrett’s esophagus and early esophageal adenocarcinoma." Therapeutic Advances in Gastroenterology 13 (January 2020): 175628482092420. http://dx.doi.org/10.1177/1756284820924209.

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Endoscopic eradication therapy (EET) has revolutionized management of Barrett’s esophagus (BE)-associated neoplasia, traditionally treated by esophagectomy, which carries very high mortality and morbidity. EET, usually performed in the outpatient setting, has a safe risk profile. It is indicated in patients with BE with high-grade dysplasia and intramucosal cancer, confirmed, and persistent low-grade dysplasia, and in highly selected cases of non-dysplastic BE and submucosal cancers. Multiple EET modalities are available and can be categorized into two groups: ablation therapies and resection

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Hebbar, Ankitha, and Venkataramappa Srinivasa Murthy. "Role of p16/INK4a and Ki-67 as specific biomarkers for cervical intraepithelial neoplasia: An institutional study." Journal of Laboratory Physicians 9, no. 02 (2017): 104–10. http://dx.doi.org/10.4103/0974-2727.199630.

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Abstract BACKGROUND: P16/INK4a and Ki-67 have emerged as important biomarkers for the detection of high-risk human papilloma virus (HR-HPV) associated dysplastic changes in the cervical biopsy samples. The increasing inter- and intra-observer variability in the diagnosis of dysplastic lesions and immature squamous metaplasia on histopathology has led to the advent of these biomarkers. This study was taken up with an aim to study their role in increasing the diagnostic accuracy in equivocal cases on histopathology. MATERIALS AND METHODS: Fifty cervical biopsy specimens were stained with p16/INK

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Das, Sucharita, Neeti Gupta, Amit Kumar, Sonal Saran, and Arvind Kumar. "Recurrent ocular surface squamous neoplasia treated with orbital exenteration." Indian Journal of Ophthalmology - Case Reports 4, no. 1 (2024): 23–25. http://dx.doi.org/10.4103/ijo.ijo_1235_23.

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Ocular surface squamous neoplasia (OSSN) consists of an array of dysplastic, pre-invasive and malignant squamous lesions that impair the ocular surface. We report a case of a 61-year-old female with recurrent OSSN and had chronic hepatitis B. She was managed surgically, excision of the lesion and cryotherapy with amniotic membrane grafting with topical Mitomycin C 0.02% was performed. She came back with recurrence after 8 months and was managed with 6 cycles of Mitomycin C. After 9 months she reported back with recurrence with light perception vision and underwent orbital exenteration.

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Steensma, David P., Rafael Bejar, Siddhartha Jaiswal, et al. "Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes." Blood 126, no. 1 (2015): 9–16. http://dx.doi.org/10.1182/blood-2015-03-631747.

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Abstract Recent genetic analyses of large populations have revealed that somatic mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human aging. Clonally restricted hematopoiesis is associated with an increased risk of subsequent diagnosis of myeloid or lymphoid neoplasia and increased all-cause mortality. Although myelodysplastic syndromes (MDS) are defined by cytopenias, dysplastic morphology of blood and marrow cells, and clonal hematopoiesis, most individuals who acquire clonal hematopoiesis during aging will never develop MDS. Therefore, acquisition

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Hanselaar, Antonius G. J. M., Neal Poulin, Martin M. M. Pahlplatz, et al. "DNA-Cytometry of Progressive and Regressive Cervical Intraepithelial Neoplasia." Analytical Cellular Pathology 16, no. 1 (1998): 11–27. http://dx.doi.org/10.1155/1998/649024.

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A retrospective analysis was performed on archival cervical smears from a group of 56 women with cervical intraepithelial neoplasia (CIN), who had received follow‐up by cytology only. Automated image cytometry of Feulgen‐stained DNA was used to determine the differences between progressive and regressive lesions. The first group of 30 smears was from women who had developed cancer after initial smears with dysplastic changes (progressive group). The second group of 26 smears with dysplastic changes had shown regression to normal (regressive group). The goal of the study was to determine if dif

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She, Poh Fong, Khairidzan Mohd Kamal, Akmal Haliza Zamli, Norra Harun, and Safinaz Mohd Khialdin. "Chemo-adjuvant therapy in recurrent conjunctival intraepithelial neoplasia." Malaysian Journal of Ophthalmology 2, no. 3 (2020): 232–37. http://dx.doi.org/10.35119/myjo.v2i3.106.

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A 68-year-old Malay male with no known medical illness presented with progressive growth of right conjunctival mass over a few months. Anterior segment examination of the right eye showed an inferior perilimbal elevated gelatinous conjunctival mass measuring 6 mm vertically x 14 mm horizontally with 360° corneal vascularisation. Excision biopsy and histopathological examination revealed areas of dysplastic cells involving the full epithelial thickness, suggestive of conjunctival intraepithelial neoplasia. The patient defaulted follow-up and presented later with recurrence involving the superio

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Thuijs, Nikki B., Féline O. Voss, Patricia C. Ewing-Graham, et al. "Expression of CK17 and SOX2 in Vulvar Intraepithelial Neoplasia: A Comprehensive Analysis of 150 Vulvar Lesions." Cancers 16, no. 23 (2024): 3966. http://dx.doi.org/10.3390/cancers16233966.

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Background: Recently, the immunohistochemical markers cytokeratin 17 (CK17) and SRY-box2 (SOX2) have been evaluated as adjuncts for the diagnosis of high-grade vulvar intraepithelial neoplasia (VIN). In the present study, the aim was to assess CK17 and SOX2 expression in VIN by studying 150 vulvar lesions, originally reported as high-grade VIN and to assess the diagnostic accuracy. Methods: All slides (H&E, p16INK4a, p53, Ki-67, CK17, and SOX2 stains) were independently assessed by six pathologists and the final diagnosis was reached in consensus meetings, as follows: 46 human papillomavir

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Vaibhav, Patel, Patel Himani, and Joshi Meghavi. "Prognostic Significance of p53 Mutation in Oral Premalignant and Malignant Lesions- a Tertiary Care Center Study." International Journal of Pharmaceutical and Clinical Research 16, no. 1 (2024): 319–25. https://doi.org/10.5281/zenodo.11094587.

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<strong>Introduction:</strong> Oral cancers accounts for up to 40% of all malignancies in developing countries including India. Early detection and treatment play pivotal roles in improving prognosis and overall survival rates. p53 immunomarker could be considered complementary to conventional prognostic evaluation. <strong>Aim:</strong> The aim of present study is to analyse the expression of p53 in relation to histopathological diagnosis along with the utility of labelling Index of p53 protein in of oral premalignant and malignant lesions. Also, to evaluates clinicopathologica

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Bhattacharya, Sumona, William Beaty, Adam S. Faye, and Jordan E. Axelrad. "Right-Sided Dysplasia in Inflammatory Bowel Disease Is Not Associated with Conventional Risk Factors for Neoplasia." Gastroenterology Insights 16, no. 2 (2025): 14. https://doi.org/10.3390/gastroent16020014.

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Introduction: In the general population, right I-sided dysplasia presents a higher risk for colorectal cancer (CRC) and metachronous dysplasia compared to left (L)-sided dysplasia. Given that patients with inflammatory bowel disease (IBD) are at higher risk for dysplasia than the general population, we sought to assess the risk factors as well as the differences in outcomes between patients with R-sided, L-sided, and both R- and L-sided dysplasia. Methods: A retrospective chart review was performed on patients at NYU Langone Health who had evidence of dysplasia on a colonoscopy between 2011 an

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Wilson, H. A., P. Blakely, J. Dang, et al. "A127 ENDOSCOPIC MUCOSAL RESECTION FOR DYSPLASTIC AND NEOPLASTIC BARRETT’S ESOPHAGUS: FINDINGS FROM A FOREGUT NEOPLASIA MULTIDISCIPLINARY DATABASE." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (2022): 149–50. http://dx.doi.org/10.1093/jcag/gwab049.126.

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Abstract Background Previously, Barrett’s esophagus with high grade dysplasia (HGD) or neoplasia was treated with esophagectomy, which is associated with a high postoperative morbidity and mortality rate. Recent guidelines support the use of endoscopic mucosal resection (EMR) for T1a esophageal adenocarcinoma (EAC) and potentially T1b EAC; however, data on long term outcomes of endoscopic treatment is lacking. We created a combined prospective and retrospective multidisciplinary database to monitor outcomes of patients with Barrett’s esophagus undergoing endoscopic treatment. Aims Our primary

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Louise, Cras, Brock Stefanie, Barbé Kurt, Locy Hanne, Broeckx Glenn, and Sahebali Shaira. "Combined HPV and CINtec PLUS testing for triaging cervical cancer screening in a Belgian cohort." Annals of Cytology and Pathology 8, no. 1 (2023): 004–10. http://dx.doi.org/10.17352/acp.000028.

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Background: Cytological screening with Human Papillomavirus (HPV) triage for equivocal results has been the routine screening procedure for cervical cancer for years worldwide. The dual-marker stain p16/Ki67 (CINtec PLUS) has been shown to offer high sensitivity and specificity in the triage of women at risk of developing HPV-related precancerous lesions. We evaluated the utility of CINtec PLUS in women with normal cytology and a positive HPV test, to see if this test can be used as a prognostic biomarker. Methods: Women of 18 years or older were assembled between January 2018 and December 202

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Alzoubaidi, Durayd, Mohamed Hussein, Vinay Sehgal, et al. "Cryoballoon ablation for treatment of patients with refractory esophageal neoplasia after first line endoscopic eradication therapy." Endoscopy International Open 08, no. 07 (2020): E891—E899. http://dx.doi.org/10.1055/a-1149-1414.

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Abstract Background and study aims Cryoablation with the Cryoballoon device is a novel ablative therapy that uses cycles of freezing and thawing to induce cell death. This single-center prospective study evaluated the feasibility of the focal cryoablation device for the treatment of areas of refractory esophageal neoplasia in patients who had undergone first line endoscopic eradication therapy (EET). Complete remission of dysplasia (CR-D) and complete remission of intestinal metaplasia (CR-IM) at first follow-up endoscopy, durability of disease reversal, rates of stenosis and adverse events we

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Zhang, Jun, Yongquan Xue, Jinlan Pan, et al. "Study On the Clonal Origin of Dysplastic Cells by Fluorescence in Situ Hybridization in Myelodysplastic Syndromes." Blood 114, no. 22 (2009): 4858. http://dx.doi.org/10.1182/blood.v114.22.4858.4858.

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Abstract Abstract 4858 Objective To determining the clonal origin of dysplatic cells in Myelodysplastic syndromes (MDS) . Methods Karyotypic analyses of bone marrow cells using R-banding technique were carried out to determine the chromosomal abnormalities. Interphase fluorescence in situ hybridization (FISH) and morphologic analysis of bone marrow aspirates were performed in the same cells to investigate the clonal origin of dysplatic cells in 8 MDS patients. Result All patients had clonal karyotypic abnormalities: simple abnormality in 1 patient, complex abnormalities in 6 patients, coexiste

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Kővári, Bence, Sándor Turkevi-Nagy, Gregory Y. Lauwers, and Kun Jiang. "Mixed Intraepithelial Neoplasia—Well-Differentiated Neuroendocrine Tumor of the Gallbladder: A Hitherto Unreported Combination." International Journal of Surgical Pathology 29, no. 6 (2021): 685–89. http://dx.doi.org/10.1177/1066896920986987.

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Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this location. Occasionally, NEN may present as a part of a mixed neoplasm, with a coexisting non-neuroendocrine component. The latest World Health Organization classification denotes these lesions as mixed neuroendocrine–non-NENs (MiNENs). A novel type of MiNEN, the mixed adenoma well-d

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Dasgupta, Shatavisha, Senada Koljenović, Thierry P. P. van den Bosch, et al. "Evaluation of Immunohistochemical Markers, CK17 and SOX2, as Adjuncts to p53 for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia (dVIN)." Pharmaceuticals 14, no. 4 (2021): 324. http://dx.doi.org/10.3390/ph14040324.

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Histological diagnosis of differentiated vulvar intraepithelial neoplasia (dVIN), the precursor of human papillomavirus (HPV)-independent vulvar squamous cell carcinoma (VSCC), can be challenging, as features of dVIN may mimic those of non-dysplastic dermatoses. To aid the diagnosis, p53-immunohistochemistry (IHC) is commonly used, and mutant expression patterns are used to support a histological diagnosis of dVIN. However, a proportion of dVIN can show wild-type p53-expression, which is characteristic of non-dysplastic dermatoses. Furthermore, recent research has identified a novel precursor

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Colegrove, K. M., F. M. D. Gullanda, D. K. Naydan, and L. J. Lowenstine. "Tumor Morphology and Immunohistochemical Expression of Estrogen Receptor, Progesterone Receptor, p53, and Ki67 in Urogenital Carcinomas of California Sea Lions (Zalophus californianus)." Veterinary Pathology 46, no. 4 (2009): 642–55. http://dx.doi.org/10.1354/vp.08-vp-0214-c-fl.

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Metastatic carcinoma of urogenital origin is a common cause of mortality in free-ranging California sea lions (Zalophus californianus). The etiology of this cancer is likely multifactorial, with viral infection, genetic factors, and exposure to environmental organochlorine contaminants possible contributing factors. In this study, expression of estrogen receptor α (ER α), progesterone receptor (PR), p53, and Ki67 were evaluated by immunohistochemistry in 12 sea lions with metastatic carcinoma, genital epithelial dysplasia, and intraepithelial neoplasia; 4 with genital epithelial dysplasia and

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Hobbie, K. R., A. B. DeAngelo, M. H. George, and J. M. Law. "Neoplastic and Nonneoplastic Liver Lesions Induced by Dimethylnitrosamine in Japanese Medaka Fish." Veterinary Pathology 49, no. 2 (2011): 372–85. http://dx.doi.org/10.1177/0300985811409443.

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Small fish models have been used for decades in carcinogenicity testing. Demonstration of common morphological changes associated with specific mechanisms is a clear avenue by which data can be compared across divergent phyletic levels. Dimethylnitrosamine, used in rats to model human alcoholic cirrhosis and hepatic neoplasia, is also a potent hepatotoxin and carcinogen in fish. We recently reported some striking differences in the mutagenicity of DMN in lambda cII transgenic medaka fish vs. Big Blue® rats, but the pre-neoplastic and neoplastic commonalities between the two models are largely

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Ştefănescu, Daniela, S. P. Pereira, M. M. Filip, A. Săftoiu, and S. Cazacu. "Advanced Endoscopic Imaging Techniques for the Study of Colonic Mucosa in Patients with Inflammatory Bowel Disease." Romanian Journal Of Internal Medicine 54, no. 1 (2016): 11–23. http://dx.doi.org/10.1515/rjim-2015-0050.

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Background. Crohn’s disease and ulcerative colitis are inflammatory bowel diseases (IBD) associated with colorectal cancer risk in long-standing diseases. In order to assess the colonic mucosa and to discover dysplastic or neoplastic lesions, advanced endoscopic techniques are needed. Such techniques are detailed in this review: chromoendoscopy, autofluorescence imaging (AFI), narrow band imaging (NBI), i-SCAN, Fujinon Intelligent Color Enhancement (FICE) and confocal laser endomicroscopy (CLE). Aim. The aim of the review is to describe and establish the clinical impact of advanced endoscopic

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