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Articles de revues sur le sujet « Early aging »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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1

Grillo, Andrea, and Paolo Salvi. "Early Vascular Aging Requires Early Action." Hypertension 82, no. 7 (2025): 1246–48. https://doi.org/10.1161/hypertensionaha.125.25115.

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Bruno, Rosa Maria, Peter M. Nilsson, Gunnar Engström, et al. "Early and Supernormal Vascular Aging." Hypertension 76, no. 5 (2020): 1616–24. http://dx.doi.org/10.1161/hypertensionaha.120.14971.

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Pulse wave velocity is an established marker of early vascular aging but may also help identifying individuals with supernormal vascular aging. We tested the hypothesis that individuals with the largest difference (Δ-age) between chronological and vascular age show the lowest rate of cardiovascular events and may thus be defined as supernormal vascular aging. Vascular age was defined as the predicted age in the best fitting multivariable regression model including classical risk factors and treatment and pulse wave velocity, in a subset of the Reference Values for Arterial Stiffness Collaborat

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Groznova, O. S., I. M. Miklashevich, V. Yu Voinova, et al. "Biomarkers of early cardiovascular aging." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 64, no. 4 (2019): 11–18. http://dx.doi.org/10.21508/1027-4065-2019-64-4-11-18.

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Genetic aspects regulate the intensity and rate of aging (no toxic effects considered), their negative role depends on the pathogenicity of the mutation. The light variant of the genetic “defect” has no clinical signs which feature a certain known genetic syndrome, but it has the biochemical, immunological, vascular and other abnormalities leading to pathological aging. In the most severe case, e.g. progeria, pathological aging is the main phenotypic symptom that manifests already in childhood. The subject of the pathological aging research covers the whole range of intermediate states. The re

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McGuire, Sandra L. "Early Children’s Literature and Aging." Creative Education 07, no. 17 (2016): 2604–12. http://dx.doi.org/10.4236/ce.2016.717245.

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Lynch, Gary, Christopher S. Rex, and Christine M. Gall. "Synaptic plasticity in early aging." Ageing Research Reviews 5, no. 3 (2006): 255–80. http://dx.doi.org/10.1016/j.arr.2006.03.008.

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Voropai, Daria, and Annebeth Kroeskop. "Catching the aging curve early." Journal of Cosmetic Dermatology 22, S1 (2023): 28–31. http://dx.doi.org/10.1111/jocd.15701.

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VAKULENKO, L. O., M. M. PROKOPIV, and N. A. HAYSTRUK. "Premature aging of the brain as a consequence of chronic stress." Ukrainian Neurological Journal, no. 4 (December 30, 2024): 60–63. https://doi.org/10.30978/unj2024-4-60.

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Population ageing is an irreversible global trend with complex medical, socioeconomic and political implications. Brain ageing often outpaces other somatic manifestations. Brain aging is characterized by reduced blood flow, a decrease in brain weight, and disruption of functional interneuronal connections due to changes in the content of neurotransmitters. There are several theories of aging: wear and tear of the body and waste, autointoxication, as a result of a weakening of a system or organ, cellular, molecular, genetic, due to excessive differentiation and specialisation, adaptation and

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Meigal, Alexander Yurievitch, Saara Mirjami Rissanen, Mika P. Tarvainen, et al. "Novel sEMG parameters for early diagnostics of neurological diseases and aging." Journal of Biomedical Technologies, no. 1 (June 2014): 2–9. http://dx.doi.org/10.15393/j6.art.2014.3041.

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Kotsis, Vasilios, Christina Antza, and Stella Stabouli. "Pathophysiology of Early Vascular Ageing-Opportunities for Treatment." Open Hypertension Journal 5, no. 1 (2013): 58–62. http://dx.doi.org/10.2174/1876526201305010058.

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The story of vascular ageing was first described in the seventeenth century when Thomas Sydenham wrote that ‘A man is as old as his arteries’. This aphorism was returned to publicity lately when Peter Nilsson reintroduced the concept of early vascular ageing. As vascular ageing is described a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modification of the signals that modulate them. In susceptible individuals this process appears to be accelerated, leading to features that comprise a condition characterized as early vascular aging (EVA). Early

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Meng, Qingcheng, and Wen Yu. "The Impact of Population Aging on Economic Growth." Advances in Economics, Management and Political Sciences 140, no. 1 (2024): 109–16. https://doi.org/10.54254/2754-1169/2024.ga18557.

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Population ageing is a global phenomenon that is now affecting many countries. For China, the main cause of population ageing was the early baby boom, which, despite the Government's family planning policy, had had little effect. At the same time, advances in health care leading to longer life expectancy and declining birth rates have also exacerbated population ageing. Population aging also has economic implications, such as labor shortages, shifting consumption patterns, and increased government social welfare spending. This study examines the overall impact of population aging on economic g

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Takatsuru, Yusuke. "Early-life stress and life." Aging 10, no. 10 (2018): 2535–36. http://dx.doi.org/10.18632/aging.101568.

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Burko, N. V., I. V. Avdeeva, V. E. Oleynikov, and S. A. Boytsov. "The Concept of Early Vascular Aging." Rational Pharmacotherapy in Cardiology 15, no. 5 (2019): 742–49. http://dx.doi.org/10.20996/1819-6446-2019-15-5-742-749.

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The age is one of the main non-modified factors which reduces the elasticity of vessels and increases the appearance of atherosclerotic plaques. A number of studies have revealed that in some people, vascular changes occur at a younger age, while the presence of only classical risk factors does not explain the development of cardiovascular events in young people. This phenomenon is described as a syndrome of early, or accelerated, vascular aging (EVA). Aspects of this premature process include endothelial dysfunction, increased arterial stiffness, thickening of the intima-media complex and imp

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Andreeva, I. V., A. S. Grigorev, and N. V. Kalina. "Tissue biomarkers of early vascular aging." Digital Diagnostics 2, no. 2S (2021): 8–9. http://dx.doi.org/10.17816/dd83173.

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Jolies, J. "Cognitive aging and early neurophychological diagnostics." Acta Neuropsychiatrica 11, no. 1 (1999): 24–27. http://dx.doi.org/10.1017/s0924270800036322.

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SUMMARYWith aging, most cognitive functions decline, especially processes concerning memorizing, attention, concentration, organizing, planning and problem solving. Neuropsychology can make an important contribution in early and differential diagnostics. The borderline between normal and pathological cognitive aging is especially important in this respect. The neuropsychologist gains insight in medical, biological, psychological and social factors of the aging person. Has the profile of complaints and deficits a normal background or is a pathological process taking place? It is important to pe

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Metelskaya, V., N. Gomyranova, A. Deev, M. Pokrovskaya, and O. Drapkina. "Biological Markers Of Early Vascular Aging." Atherosclerosis 287 (August 2019): e269. http://dx.doi.org/10.1016/j.atherosclerosis.2019.06.832.

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Kajantie, Eero. "Early-life events. Effects on aging." Hormones 7, no. 2 (2008): 101–13. http://dx.doi.org/10.1007/bf03401501.

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Antza, Christina, Ioannis Doundoulakis, Evagelos Akrivos, et al. "Early Vascular Aging Risk Assessment From Ambulatory Blood Pressure Monitoring: The Early Vascular Aging Ambulatory Score." American Journal of Hypertension 31, no. 11 (2018): 1197–204. http://dx.doi.org/10.1093/ajh/hpy115.

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Neumaier, Lukas, Gabriele C. Eder, Yuliya Voronko, Karl A. Berger, Gusztáv Újvári, and Karl Knöbl. "Advanced UV-fluorescence image analysis for early detection of PV-power degradation." EPJ Photovoltaics 14 (2023): 9. http://dx.doi.org/10.1051/epjpv/2023001.

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Reliability and durability of photovoltaic modules are a key factor for the development of emerging PV markets worldwide. Reliability is directly dependent on the chemical and physical stability of the polymeric encapsulation materials. One method capable of detecting ageing effects of the polymeric encapsulant directly on-site is UltraViolet Fluorescence (UVF) imaging. This work deals with advanced imaging analysis of UVF images and the subsequent correlation to electrical parameters of PV modules, which were exposed to climate-specific, long-term, accelerated aging procedures. For establishi

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Cervellati, Carlo, Giuseppe Valacchi, and Giovanni Zuliani. "Early elevation of BACE1 in dementia." Aging 13, no. 22 (2021): 24480–81. http://dx.doi.org/10.18632/aging.203727.

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Rajkumar, R. Vinodh. "Biomechanics Specialization in Aging Science and Research: Biomechanical Gerontology or Geronto-Biomechanics?" International Journal of Science and Healthcare Research 7, no. 3 (2022): 191–99. http://dx.doi.org/10.52403/ijshr.20220727.

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Aging process becomes a miserable phase of lifespan of various individuals. Gerontology and Geriatrics exclusively deal with researching complex human ailments pertinent to old age in order to overcome the challenges posed by several irreversible physiological changes occurring with aging. Inevitably, homeostasis declines and massive allostasis gets organized during aging to destroy the functional independence and survival potential. Controlling the rate of aging process is the only possible self-regulating strategy available to each individual to enjoy Morbidity-Attenuated Life Years (MALYs)

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Kim, Sang Nam. "The experience of ‘aging-well’ in early sixties woman." Korean Association For Learner-Centered Curriculum And Instruction 22, no. 23 (2022): 989–1002. http://dx.doi.org/10.22251/jlcci.2022.22.23.989.

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Objectives The purpose of this study was to verify the experience of ‘aging-well’ for a early sixties. Subject of this study was six early sixties who live in Daegu. Methods The data was collected by depth interview of experience of ‘aging-well. sixty years old woman who get marriage in city of D. if you have any question, I did telephone counseling more. The data collected was analysis using phenomenological method be due to Colaizzi(1978). Results The result were five meaning that ‘going with aging’, ‘living dependent another big power’, ‘active encount’, ‘walking positively in aging’, ‘a ri

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Bernal, Giovanna M., Joshua S. Wahlstrom, Clayton D. Crawley, et al. "Loss of Nfkb1 leads to early onset aging." Aging 6, no. 11 (2014): 931–42. http://dx.doi.org/10.18632/aging.100702.

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Simons, Ronald L., Man-Kit Lei, Steven R. H. Beach, et al. "Testing Life Course Models Whereby Juvenile and Adult Adversity Combine to Influence Speed of Biological Aging." Journal of Health and Social Behavior 60, no. 3 (2019): 291–308. http://dx.doi.org/10.1177/0022146519859896.

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The present study extends prior research on the links between social adversity and aging by employing more comprehensive measures of adversity and a new gene expression index of aging. Hierarchical regression and 20 years of data from a sample of 381 black Americans were used to test models regarding the impact of social adversity on speed of aging. Consistent with the early life sensitivity model, early adversity continued to predict accelerated aging after controlling for adult adversity. Contrary to the pathway model, adult adversity was not related to aging following controls for early adv

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An, Yeji, Rahkyung Kim, Eunsam Kim, Hyunjoo Lee, and ChungEun Lee. "Exploratory Study on the Concept of Premature Aging and Support Measures for Workers with Developmental Disabilities." Korean Society of vocational Rehabilitation 34, no. 3 (2024): 47–68. https://doi.org/10.24226/jvr.2024.12.34.3.47.

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This study aims to explore the phenomenon of early aging in workers with developmental disabilities, to clarify the concept of early aging, and to examine the associated workplace and daily life challenges and supportive measures. To achieve this, semi-structured interviews were conducted with eleven participants, including workers with developmental disabilities, support professionals, and parents, using the Focus Group Interview (FGI) method. The findings reveal that early aging is a prevalent experience among workers with developmental disabilities, reportedly occurring approximately 15 yea

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Hong, Kum-Hee, and Ju-Young Ha. "Aging Anxiety, Factors of Successful Aging and Preparation for Aging in Early and Late Middle Age." Journal of Korean Public Health Nursing 29, no. 1 (2015): 29–39. http://dx.doi.org/10.5932/jkphn.2015.29.1.29.

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Gayatri, Yeole* Ajay Baitule Himani Malode Jaydeep Wankhade. "Beyond Beauty: Exploring the Impact of Cosmeceuticals on Early Skin Aging." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3823–34. https://doi.org/10.5281/zenodo.15490334.

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Aging, particularly early or premature aging, is influenced by both genetic and environmental factors. Early skin aging results from changes in the skin’s structure, including collagen and elastin degradation, free radical damage, and hormonal shifts. Environmental elements such as excessive sunlight, poor nutrition, lack of sleep, and smoking accelerate this process. The biological age of the skin can be evaluated by its thickness, elasticity, and moisture levels. Cosmeceuticals, including peptides, vitamins, botanicals, and hydroxy acids, play a significant role in the prevention and t

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Boubred, Farid, Laurent Daniel, Christophe Buffat, et al. "Early postnatal overfeeding induces early chronic renal dysfunction in adult male rats." American Journal of Physiology-Renal Physiology 297, no. 4 (2009): F943—F951. http://dx.doi.org/10.1152/ajprenal.90704.2008.

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Low birth weight is associated with an increased risk of hypertension and renal dysfunction at adulthood. Such an association has been shown to involve a reduction of nephron endowment and to be enhanced by accelerated postnatal growth in humans. However, while low-birth-weight infants often undergo catch-up growth, little is known about the long-term vascular and renal effects of accelerated postnatal growth. We surimposed early postnatal overfeeding (OF; reduction of litter size during the suckling period) to appropriate-birth-weight (NBW+OF) and intrauterine growth restriction (IUGR; IUGR+O

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Sandi, Carmen. "Biological Signatures of Brain Aging and Accelerated Aging by Early Life Threat." Biological Psychiatry 85, no. 3 (2019): 187–88. http://dx.doi.org/10.1016/j.biopsych.2018.11.020.

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Pahuja, Kavita, and Amardeep Bissa. "Segmental Representation of Intimal Thickness in Ascending Aorta as Early Clinical Marker of Aging." International Journal of Anatomy and Research 9, no. 2.1 (2021): 7955–59. http://dx.doi.org/10.16965/ijar.2021.116.

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Background: Intimal thickness is the innermost layer of aorta; play a vital role in development of atherosclerotic changes. It may vary in the different parts of the aorta and may increase with age. Methods: 120 aortas of adult human forensic bodies were taken. Histological slides were formed and the thickness of different segments of aorta were measured microscopically. Data were statically analyzed using ANOVA, p test methods. Results and Discussion: There is no significant difference of Intimal thickness in different segments of ascending aorta though it significantly increase with age may

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Nilsson, Peter. "Early vascular aging (EVA): consequences and prevention." Vascular Health and Risk Management Volume 4 (June 2008): 547–52. http://dx.doi.org/10.2147/vhrm.s1094.

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Fang, Zhou. "W. B. Yeats’s Early Poetry of Aging." Yeats Journal of Korea 48 (December 30, 2015): 279–91. http://dx.doi.org/10.14354/yjk.2015.48.279.

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Allman, David, and Juli P. Miller. "The aging of early B-cell precursors." Immunological Reviews 205, no. 1 (2005): 18–29. http://dx.doi.org/10.1111/j.0105-2896.2005.00269.x.

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Price, Joseph L. "Aging, Preclinical Alzheimer Disease, and Early Detection." Alzheimer Disease & Associated Disorders 17, Sup 2 (2003): S60—S62. http://dx.doi.org/10.1097/00002093-200304002-00009.

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Pruchno, R. A., M. Wilson-Genderson, M. Rose, and F. Cartwright. "Successful Aging: Early Influences and Contemporary Characteristics." Gerontologist 50, no. 6 (2010): 821–33. http://dx.doi.org/10.1093/geront/gnq041.

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O'Brien, Janice. "Early findings from the Dog Aging Project." Companion Animal 29, no. 8 (2024): 1–3. http://dx.doi.org/10.12968/coan.2023.0039.

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Initial cancer findings from the Dog Aging Project reveal that there is no difference in cancer rates between purebred and mixed-breed dogs, that malignant tumours are nearly twice as common as benign tumours (rates of 29.7 per 1000 dogs, and 14.7 per 1000 dogs, respectively) and that skin tumours of the limb or foot are overwhelmingly the most common type of tumour in this cohort of American dogs. Surprisingly, owner-reported perceptions of pet health after a tumour diagnosis were still overwhelmingly positive. These findings generate more hypotheses that require testing, which will be the go

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Sayer, Avan Aihie, and David Barker. "The early environment, developmental plasticity and aging." Reviews in Clinical Gerontology 12, no. 3 (2002): 205–11. http://dx.doi.org/10.1017/s0959259802012339.

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Darwin described how animal populations have two adaptation strategies: natural selection based on genetic variation acting over many generations, and developmental plasticity acting within the lifetime of an individual. The contribution of these processes can be difficult to distinguish at the individual level, and the relevance of human developmental plasticity to aging and health in later life is only now being recognized. The formal definition of developmental plasticity is ‘the ability of a single genotype to produce more than one alternative form of structure, physiological state or beha

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Va’vra, J. "Physics and chemistry of aging – early developments." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 515, no. 1-2 (2003): 1–14. http://dx.doi.org/10.1016/j.nima.2003.08.124.

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Jagust, William J. "Early life sets the stage for aging." Proceedings of the National Academy of Sciences 113, no. 33 (2016): 9148–50. http://dx.doi.org/10.1073/pnas.1609720113.

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Hawkins, Stacy S., Carol Feinberg, Melissa Matzke, and Ronni Weinkauf. "Objective measurements detect early anti-aging benefits." Journal of the American Academy of Dermatology 50, no. 3 (2004): P27. http://dx.doi.org/10.1016/j.jaad.2003.10.110.

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Kim, Harper, Danitra Parker, Madison Hardiman, et al. "EARLY-LIFE PROTEIN TRANSLATION SPIKE DRIVES AGING VIA JUVENILE HORMONE/GERMLINE STEM CELL SIGNALING." Innovation in Aging 6, Supplement_1 (2022): 130. http://dx.doi.org/10.1093/geroni/igac059.520.

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Abstract Protein translation (PT) is high in early-adulthood across invertebrates, rodents, and humans but sharply declines thereafter. It has been implicitly assumed that elevated PT at young ages is beneficial to health and PT ends up dropping as a passive byproduct of aging. However, whether this holds true and how dynamic fluctuations in PT over time impact aging remain unknown. In Drosophila, we show that a transient PT spike in early-adulthood exerts long-lasting negative impacts on aging trajectories and proteostasis in later-life. Conversely, blocking the early-life PT spike robustly i

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Jswd, Jswd, Ushna Asghar, Khalid Iqbal, and Iqra Almas. "Early Aging in Bio-Cultural Perspectives: A Qualitative Analysis of District Multan." JOURNAL OF SOCIAL WORK AND SUSTAINABLE DEVELOPMENT 1, no. 1 (2022): 51–61. http://dx.doi.org/10.52587/jswsd.v1i1.3.

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This qualitative ethnographic study attempts to understand the biological and cultural causes of early aging, the problems generated due to nutrition, traditional and cultural values. This study involves 24 early aging respondents from three Union Councils of Multan city of south Punjab. The data were generated by conducting detailed face-to-face interviews with the participants. The study highlights the bio-cultural causes of early aging through thematic analysis. This study recommends that related institutions could play a significant role in educating the families to help reduce the issues

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Leparulo, Alessandro, Marta Bisio, Nelly Redolfi, Tullio Pozzan, Stefano Vassanelli, and Cristina Fasolato. "Accelerated Aging Characterizes the Early Stage of Alzheimer’s Disease." Cells 11, no. 2 (2022): 238. http://dx.doi.org/10.3390/cells11020238.

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For Alzheimer’s disease (AD), aging is the main risk factor, but whether cognitive impairments due to aging resemble early AD deficits is not yet defined. When working with mouse models of AD, the situation is just as complicated, because only a few studies track the progression of the disease at different ages, and most ignore how the aging process affects control mice. In this work, we addressed this problem by comparing the aging process of PS2APP (AD) and wild-type (WT) mice at the level of spontaneous brain electrical activity under anesthesia. Using local field potential recordings, obta

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Zheng, Meng-yi, Quan-hui Zhao, Ying-chi Liu, et al. "Early Vascular Aging and Risk Factors Among a Population Aged 50 and Below in Kailuan Study." American Journal of Hypertension 33, no. 9 (2020): 887. http://dx.doi.org/10.1093/ajh/hpaa107.

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Abstract Background To examine the frequency of early vascular aging and risk factors in an adult population with age ≤50 years old in Kailuan. Methods A total of 21,952 subjects aged ≤50 years without previous history of cardiovascular and cerebrovascular diseases and having completed brachial-ankle pulse wave velocity test in 2010–2016 were recruited. The mean plus 2 standard deviations (mean + 2SD) of brachial-ankle pulse wave velocity in 1,813 healthy population without hypertension, diabetes, dyslipidemia, and smoking were calculated and used as the reference value for early vascular agin

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Schmitz, Lauren. "EARLY-LIFE EXPOSURE TO THE GREAT DEPRESSION AND THE PACE OF BIOLOGICAL AGING." Innovation in Aging 7, Supplement_1 (2023): 206. http://dx.doi.org/10.1093/geroni/igad104.0679.

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Abstract The Developmental Origins of Health and Disease hypothesis proposes that insults to early-life development can result in increased risk for aging-related disease later in life. There is growing interest within gerontology in the potential role such early life exposures play in shaping processes of aging. However, causal research linking early-life exposures to processes of aging in later life is rare. Moreover, there are difficulties in distinguishing the impacts of exposures occurring at different stages of early life development. In this study, we build on a quasi-natural experiment

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Lazar, Mihai, Ruxandra Moroti, Ecaterina Constanta Barbu, et al. "The Impact of HIV on Early Brain Aging—A Pathophysiological (Re)View." Journal of Clinical Medicine 13, no. 23 (2024): 7031. http://dx.doi.org/10.3390/jcm13237031.

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Background/Objectives: This review aims to provide a comprehensive understanding of how HIV alters normal aging trajectories in the brain, presenting the HIV-related molecular mechanisms and pathophysiological pathways involved in brain aging. The review explores the roles of inflammation, oxidative stress, and viral persistence in the brain, highlighting how these factors contribute to neuronal damage and cognitive impairment and accelerate normal brain aging. Additionally, it also addresses the impact of antiretroviral therapy on brain aging and the biological markers associated with its occ

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Alberts, Susan. "THE LONG LIVES OF PRIMATES AND THE ‘INVARIANT RATE OF AGING’ HYPOTHESIS." Innovation in Aging 7, Supplement_1 (2023): 62. http://dx.doi.org/10.1093/geroni/igad104.0197.

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Abstract Can we slow the rate of human aging? A decades-long trend toward increasing life expectancy and greater lifespan equality in human populations raises the possibility that we can. But the rate of aging is closely correlated with other traits and may be highly constrained or even relatively fixed within species, according to the ‘invariant rate of aging’ hypothesis. To gain insight into biological constraints on aging, we use an unprecedented collection of datasets from 39 human and nonhuman primate populations, representing 7 genera distributed across the order Primates. We show that t

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Baker, Darren J., Karthik B. Jeganathan, Liviu Malureanu, Carmen Perez-Terzic, Andre Terzic, and Jan M. A. van Deursen. "Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice." Journal of Cell Biology 172, no. 4 (2006): 529–40. http://dx.doi.org/10.1083/jcb.200507081.

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Aging is a highly complex biological process that is believed to involve multiple mechanisms. Mice that have small amounts of the mitotic checkpoint protein BubR1 age much faster than normal mice, but whether other mitotic checkpoint genes function to prevent the early onset of aging is unknown. In this study, we show that several aging-associated phenotypes appear early in mice that are double haploinsufficient for the mitotic checkpoint genes Bub3 and Rae1 but not in mice that are single haploinsufficient for these genes. Mouse embryonic fibroblasts (MEFs) from Bub3/Rae1 haploinsufficient mi

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Heyn, Patricia. "Ageism and People With Early-Onset Disability." Innovation in Aging 4, Supplement_1 (2020): 847. http://dx.doi.org/10.1093/geroni/igaa057.3107.

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Abstract People with disabilities are underrepresented in health research and usually they are explicitly excluded from research participation. There are no longitudinal studies that follows cohorts with disabilities to learn about their healthspan and aging processes. Thus, we know very little about how people with early onset disability age, and the medical conditions and health risk factors contributing to the “accelerated aging” phenomena commonly observed in this population. Our research group has been following a cohort group of individuals with pediatric onset disability since 2013. We

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Szepietowska, Ewa Małgorzata. "Can our life resources support successful aging?" Kwartalnik Naukowy Fides et Ratio 4, no. 52 (2022): 104–13. http://dx.doi.org/10.34766/fetr.v4i52.1141.

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The projections showing trends towards increased ageing of the populations and the resulting challenges to the welfare system, health care or economy have led to a great number of publications exploring possible ways to prevent cognitive decline in late life. Successful ageing, in accordance with the definition of the term, is reflected by cognitive, motor and social capacities maintained at a level incommensurate with normal aging. Attempts to explain this aging pattern refer to the so-called cognitive reserve. The concept relates to the resources acquired from early childhood through educati

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Suh, Yousin. "OVARIAN AGING: A TARGET FOR GEROPROTECTION IN WOMEN." Innovation in Aging 7, Supplement_1 (2023): 299–300. http://dx.doi.org/10.1093/geroni/igad104.0999.

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Abstract The ovary is the first organ to undergo early-onset aging in the human body, affecting both fertility and overall health in women. However, the biological mechanisms underlying human ovarian aging have been poorly understood. To understand the molecular, cellular, and genetic basis of ovarian aging in humans, we performed integrative single-nuclei multi-omics analyses of young and reproductively aged human ovaries. Our analysis reveals coordinated changes in the regulatory landscapes across all cell types in the ovary during aging, characterized by transcriptomic and chromatin accessi

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