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Articles de revues sur le sujet « Effervescent Time »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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1

Arshad, Muhammad Sohail, Kabindra Sedhain, Amjad Hussain, et al. "Quantification of carbon dioxide released from effervescent granules as a predictor of formulation quality using modified Chittick apparatus." Tropical Journal of Pharmaceutical Research 18, no. 3 (2021): 449–58. http://dx.doi.org/10.4314/tjpr.v18i3.1.

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Purpose: To develop a method for the measurement of carbon dioxide (CO2) released from effervescent formulations. Methods: Effervescent granules were prepared using sodium bicarbonate and citric acid by fusion and solvent-assisted granulation methods. The amount of CO2 released was determined from the maximum pressure of gas release, time profile of pressure gradient using modified Chittick apparatus and gravimetric changes following effervescence. Results: The amount of CO2 released from effervescent granules prepared by fusion method was 8.125, 8.763 and 7.98 mM/g measured by ide

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MD, Abuzar* Nivedita Chatterjee. "Formulation And Evaluation of Effervescent Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3576–87. https://doi.org/10.5281/zenodo.15479544.

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Effervescent tablets represent new solid oral dosage forms characterized by the fast disintegration after contact with water, releasing carbon dioxide and giving a solution or dispersion that can be administered orally. Effervescent tablets are many times more beneficial than other dosage forms such as faster drug absorption, greater patient compliance, better taste masking, and effectiveness in patients who have difficulty in swallowing. The preparation of effervescent tablets involves a delicate proportioning of active pharmaceutical ingredients (APIs) and effervescent materials like citric

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SJ, Jadhav, Gangurde AB, and Jadhav JA. "Formulation Development and Evaluation of Effervescent Granules of Rizatriptan Benzoate." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 02 (2024): 911–16. http://dx.doi.org/10.25258/ijpqa.15.2.58.

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The present study describes the formulation and development of rizatriptan benzoate (RZB) effervescent granules and compares its dissolution rate against the conventional rizatriptan benzoate tablets. Earlier, placebo-effervescent granules were prepared to optimize the concentration of citric acid, NaHCO3 and tartaric acid and its effect on CO2 content and effervescence time. Effervescent granules were prepared by direct sifting and blending of ingredients. Rizatriptan effervescent granules were prepared by the addition of RZB in the above-optimized placebo granule formula and evaluated for va

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Katara Kinjalben, Katara Kinjalben, and Mr Sunil Ohja Mr.Sunil Ohja. "Strategies for Formulation and Evaluation of Poly Herbal Effervescent Granules for the Management of Digestive Activity’’." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 491–94. https://doi.org/10.35629/4494-1003491494.

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This research focused on formulating and evaluating effervescent granules of fennel (Foeniculum vulgare)seed Powder, known for its carminative, digestive, and antispasmodic properties. The goal was to enhance the palatability of herbal formulations by reducing bitterness while improving dissolution, ensuring a quicker onset of action. Citric acid, tartaric acid, sodium bicarbonate, and other excipients were incorporated using the wet granulation method to prepare effervescent granules.fennel seed powder was formulated into four different batches (F1-F4), and their flow properties, PH, and effe

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Divya, Maluskar* Dr. Tambe S. E. "Formulation, Development and Evaluation of Effervescent Tooth Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2135–50. https://doi.org/10.5281/zenodo.15397743.

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Tooth tablets are small, bite-sized chewable tablets that can be chewed into a paste and they are showing a similar effect as traditional oral toothpaste. The main aim is to provide a convenient and effective oral care solution. Biomin F a fluoride releasing compound is known for its ability to remineralize enamel and protect against dental caries. The objective of this study was design an effervescent tablet incorporating Biomin F, which would release fluoride ions in a controlled manner when dissolved in water, thereby ensuring the target delivery to the teeth. The powder blend was evaluated

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Erni Rustiani and Ulfa Nur Awinda. "Effervescent Granule Formulation Combination of Coleus amboinicus Leaves Extract and Tamarindus indica Pulp Extract." Jurnal Jamu Indonesia 7, no. 1 (2022): 25–30. https://doi.org/10.29244/jji.v7i1.214.

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Coleus amboinicus and Tamarindus indica effectively decrease glucose in the blood with work mechanisms by reducing oxidative stress in the body. Flavonoid contains in these plants was thought to play a role as anti-diabetes. This study made an effervescent granule preparation from a mixture of Coleus amboinicus leaf extract and Tamarind (Tamarindus indica) pulp, with additional ingredients of citric acid, tartaric acid, and sodium bicarbonate. The effervescence reaction masked the extract's unpleasant taste. The three effervescent granule formulas manufacture using a dry granulation method. Ea

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Surini, Silvia, Mutiah Rakhma Wisnu Wardani, and Erny Sagita. "EVALUATING OF EFFERVESCENT TABLETS CONTAINING GRAPE SEED (VITIS VINIFERA L.) EXTRACT AS A NUTRACEUTICAL." International Journal of Applied Pharmaceutics 9 (October 30, 2017): 150. http://dx.doi.org/10.22159/ijap.2017.v9s1.76_83.

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Objective: Grape is one of the most well-known fruits. People usually consume only the fruit and the skin; however, the seed is the part of the fruitthat contains important antioxidant rich polyphenol. However, grape seed and its extract have an unpleasant taste. Therefore, this study aimed toformulate effervescent tablets containing grape seed extract (GSE) to overcome the unpleasant taste.Methods: Effervescent tablets of GSE were formulated using three formulas, each with a different percentage of the effervescent mix. The tablets wereprepared using wet granulation method at 40% relative hum

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Liu, Zhongbing, Xuemei Sun, Tiantian Liang, et al. "Preparation and Characterization of the Biological Compound Effervescent Granule of Calcium Acetate." Current Pharmaceutical Biotechnology 20, no. 11 (2019): 934–44. http://dx.doi.org/10.2174/1389201020666190628144637.

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Objective: Calcium acetate (Ca(CH3COO)2) is commonly used in calcium supplement for medicine, which is used as an auxiliary agent to treat osteoporosis. An effervescent granule is widely used in medical industry due to its palatability. The purpose of this study is to develop a new preparation of compound effervescent granule of the biological calcium acetate (Ca(CH3COO)2 effervescent granule), overcoming the disadvantages of the previous other dosage forms of calcium and thus enhancing the therapeutic efficacy. Methods: The biological Ca(CH3COO)2 effervescent granule was prepared by the wet g

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Senekowitsch, Stefan, Constantin Foja, Toni Wildgrube, et al. "Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine." Pharmaceutics 15, no. 3 (2023): 1012. http://dx.doi.org/10.3390/pharmaceutics15031012.

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Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs. The hypothesis of the present work was that the induction of gastric motility by intragastric release of carbon dioxide from effervescent granules could promote the mixing of drugs into the chyme under postprandial conditions, resulting in a prolonged drug absorption. For this purpose, an effervescent and a non-effervescent granule formulation of caffeine as a marker for gastric emptying were developed. In a three-way crossover

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Das, Sahil1* Painuly Neelam2. "Formulation And Evaluation Of Herbal Effervescent Tablets For The Treatment Of Constipation." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 736–45. https://doi.org/10.5281/zenodo.11622689.

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The formulation and evaluation of herbal effervescent tablets for constipation were conducted to develop a natural, effective, and patient-friendly treatment option. Four formulations were prepared using Indian Senna, Psyllium husk, Bael fruit pulp, and other excipients. The tablets were assessed for weight variation, hardness, friability, effervescence time, and disintegration time. All formulations met the weight variation limit, indicating uniformity in dosage. Tablet hardness ranged from 5.8 to 8.3 N, ensuring appropriate mechanical strength. Friability values were below 1%, signifying tab

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Das, Sahil1* Painuly Neelam2. "Formulation And Evaluation Of Herbal Effervescent Tablets For The Treatment Of Constipation." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 736–47. https://doi.org/10.5281/zenodo.11666060.

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The formulation and evaluation of herbal effervescent tablets for constipation were conducted to develop a natural, effective, and patient-friendly treatment option. Four formulations were prepared using Indian Senna, Psyllium husk, Bael fruit pulp, and other excipients. The tablets were assessed for weight variation, hardness, friability, effervescence time, and disintegration time. All formulations met the weight variation limit, indicating uniformity in dosage. Tablet hardness ranged from 5.8 to 8.3 N, ensuring appropriate mechanical strength. Friability values were below 1%, signifying tab

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Nadendla, Rama Rao, Sandeep Kanna, and Juluri Satyanarayana. "DESIGN AND EVALUATION OF RIVAROXABAN EFFERVESCENT GRANULES." INDIAN DRUGS 61, no. 03 (2024): 61–64. http://dx.doi.org/10.53879/id.61.03.14149.

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The present investigation is concerned with the formulation and development of rivaroxaban (RN) effervescent granules using a dry granulation process. A 23 factorial design was employed using Design-Expert® software to develop an ideal formulation. Formulations were evaluated, and showed outstanding flow characteristics, compositions with low moisture content contributing to their stability, effervescence time of less than 180 seconds and in vitro profile of over 90% for 30 minutes.

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Raza, Sajid, Sujjad Zaman, Rubia Anwer, et al. "PREPARATION OF STABLE EFFERVESCENT GRANULES FROM THE EXTRACT OF CARICA PAPAYA FOR THE TREATMENT OF THROMBOCYTOPENIA ASSOCIATED WITH DENGUE." Insights-Journal of Health and Rehabilitation 3, no. 3 (Health & Allied) (2025): 104–10. https://doi.org/10.71000/dkbcjc18.

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Background: Dengue fever is a rapidly spreading mosquito-borne viral infection that presents with severe symptoms, including thrombocytopenia and platelet dysfunction. Due to the absence of a definitive antiviral treatment or widely available vaccine, supportive therapies are critical in managing the disease. Medicinal plants such as Carica papaya have shown therapeutic promise in restoring platelet counts due to their bioactive compounds like papain. However, traditional dosage forms of papaya extract have limitations in stability and patient compliance. Objective: To develop and evaluate sta

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Hasbullah, Umar Hafidz Asy'ari, Miftahul Wahidatun Ni’mah, Endang Is Retnowati, and Rini Umiyati. "Physical, Chemical, and Sensory Properties of Robusta Coffee Effervescent Tablets Formulated in Various Organic Acids." Pelita Perkebunan (a Coffee and Cocoa Research Journal) 38, no. 1 (2022): 54–69. http://dx.doi.org/10.22302/iccri.jur.pelitaperkebunan.v38i1.489.

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Coffee effervescent products are an innovation in coffee formulation. The compounds that play a role in effervescent are acids and bases. Type of organic acid give an impact on the effervescent characteristics. This study aimed to examine the effect of type of organic acid on physical, chemical, and sensory properties ofRobusta coffee effervescent tablets. This study used a completely randomized design with three acids in the formulation, namely citric acid, tartaric acid, and malic acid. Samples were analyzed in three replications. Making effervescent tablets was done by compression technique

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Herlina, Herlina, Tri Yanuarto, Elly Mulyani, and Yuni Hartati. "Formulation of Effervescent Granule Telang Flower Essense (Clitoria Ternate L.) and Rimau Gerga Lebong Orange (Citrus Nobilis) as a Health Drink." SINTA Journal (Science, Technology, and Agricultural) 5, no. 1 (2024): 83–92. https://doi.org/10.37638/sinta.5.1.83-92.

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Butterfly pea flowers (Clitoria ternatea L.) contain chemicals, namely anthocyanin flavanoids, which are a subclass of water-soluble flavanoids and are responsible for the color of the flowers. RGL oranges (Citrus nobilis) are a high source of vitamin C which is effective as an antioxidant which can neutralize free radicals. Effervescent granules have high solubility in water making them very easily absorbed and contain carbonates which provide a fresh taste sensation. The aim of making effervescent granules is to find out whether butterfly pea flower essence with RGL oranges can be formulated

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Olayemi, Olubunmi, Favour Morka, and Omoshallewa Adesola. "Preliminary physicochemical evaluation of effervescent granules of Anogiessius leocarpus stem bark extract." Journal of Current Biomedical Research 3, no. 4, July-August (2023): 1154–63. http://dx.doi.org/10.54117/jcbr.v3i4.7.

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The plant Anogeissus leiocarpus is traditionally used in the treatment of ulcers including gastric ulcers. Effervescent granules are unique, pleasant-tasting oral formulations which are ingested as liquids. This study is a preliminary development and evaluation of effervescent granules of the aqueous extract of the stem bark of Anogeissus leiocarpus. The extract was obtained by drying the filtrate gotten from maceration of the dried, crushed stem bark in water. The acids (citric and tartaric acid) were each combined with the base (sodium bicarbonate) in 1:1 and 1:2 ratios and these were mixed

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Nikam, Vikrant, and Avinash Bhosale. "Design, Development and Physicochemical Evaluation of Effervescent Tablets of Antihistamine Drug." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1520–26. http://dx.doi.org/10.25258/ijddt.13.4.61.

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Purpose: Effervescent bilastine tablets were the focus of this investigation because of their ease of administration and the fact that some patients, especially younger ones or those with impaired swallowing abilities, have trouble ingesting oral dosage forms. Methods: Using the wet granulation process, 20 mg of effervescent bilastine tablets were produced. Pre-compression properties assessed for powder blend and granule combination. Here are some post-compression properties of the tablets that were examined: friability, hardness, drug content, pH, dissolution time, content uniformity, water c

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Aditama, Agnis Pondineka Ria, Alfi Nur Ramadhani, Asa Falahi, and Dewi Rashati. "Evaluation and Physical Stability Effervescent Powder of Okra Leaves Extract (Abelmoschus esculentus) as an Antidiabetic Supplement." Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) 3 (November 13, 2023): 1. http://dx.doi.org/10.18860/planar.v3i0.2466.

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Diabetes Mellitus (DM) is a disease characterized by hyperglycemia, and the most frequently encountered is type 2, which requires oral anti-diabetic therapy. Economic and socio-cultural factors also influence people in choosing alternative medicine. Okra (Abelmoschus esculentus (L.) Moench) is a medicinal plant containing the active substances flavonoids, α-cellulose, and hemicellulose in its leaves which have anti-diabetic properties, especially type 2 DM. This research aims to make a formula and determine the physical stability of the anti-diabetic supplement preparations in the form of effe

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Sugiyanto, Sugiyanto, Wibowo Wibowo, and Dedy Prayogo. "Perbandingan Uji Sifat Fisik Serbuk Effervesent Ekstrak Bunga Telang (Clitoria Ternatea.L)." Malahayati Nursing Journal 4, no. 11 (2022): 2913–24. http://dx.doi.org/10.33024/mnj.v4i11.7214.

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ABSTRACT The telang flower plant (Clitoria ternatea.L) contains phenolic compounds, flavonoids, flavonols, glycosides and anthocyanins which have potential as antioxidants. Antioxidant compounds that are often found in telang flower plants are often used as traditional medicine in the form of drinks. Study was to identify a formula that met the requirements for physical properties based on the characteristics of the effervescent powder on the effect of variations in citric acid and tartaric acid on the effervescent powder formula of telang flower extract. This study used 3 formulas using varia

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Pradnya, Narkhede* Pallavi Gholap. "Formulation And Evaluation of Tablets Containing Fennel and Ginger for The Treatment of Gastroesophageal Reflux Disease." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2674–82. https://doi.org/10.5281/zenodo.15093290.

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Background: For the purpose of treating gastroesophageal reflux disease, tablets containing powdered ginger and fennel were formulated using Effervescent agent/gas producing agent. Tablets enhance medication bioavailability and enable local drug distribution to the stomach when formulated using effervescent agent which prolongs their gastric residence duration.  Methods: Using the direct compression method, tablets containing HPMC E50 and HPMC K4M, talc, magnesium stearate, powdered fennel and ginger, and sodium bicarbonate (gas producing agent) were prepared. Physical characteristics suc

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Pratama, Reza, Munir Alinu Mulki, M. Ramadhan Saputro, Afifah Rusyda Sani, and Ratu Siti Robiatul Awaliyah. "Pengaruh eksipien terhadap sifat fisik granul effervescent : Review." An-Najat 2, no. 1 (2024): 137–54. http://dx.doi.org/10.59841/an-najat.v2i1.1071.

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The use of various plant species, which are then formulated using pharmaceutical technology in the form of effervescent granule preparations, is a strategy to increase the practicality and public interest in consuming herbal medicines. The natural ingredients most commonly used as the main ingredients in the manufacture of effervescent granules include fruits, rhizomes, fruit peels, leaves and seeds. Effervescent granules are a mixture of acidic and alkaline compounds which, when added to water, produce a carbon dioxide reaction. This creates a foam that gives a fresh taste effect and can mask

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Shailee, V. Tiwari, N. Kshirsagar Tatwashil, E. Chavan Gulab, et al. "Formulation and Evaluation of Herbal Effervescent Tablet." International Journal for Modern Trends in Science and Technology 11, no. 06 (2025): 51–56. https://doi.org/10.5281/zenodo.15609174.

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<em>The study aims to obtain the best formulation for the production of effervescent tablets made from ginger as well as to determine their physicochemical characteristics. In present work an attempt has been made to formulate an effervescent tablet containing immediate release Gingerol using various acids and base. The effervescent tablets were prepared by wet granulation technique. Lactose as a binder and talc as lubricant were used. There are three formulations that content the citric acid and sodium bicarbonate were formulated.</em> <em>These three formulations were evaluated for the flow

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Ramadhia, Muflihah, and Ichsan Ichsan. "Pengolahan Lidah Buaya (Aloe Vera) Menjadi Granul Effervescent sebagai Minuman Kesehatan dan Analisis Peningkatan Nilai Ekonomisnya." Jurnal Ekonomi Bisnis dan Kewirausahaan 7, no. 2 (2018): 149. http://dx.doi.org/10.26418/jebik.v7i2.25991.

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One of the leading sectors of commodities mainstay of West Kalimantan which have a comparative advantage, especially in the city and district of North Pontianak is aloe vera. Aloe vera usually processed and sale only in the form of raw material and provide little added economic value to society. The purpose of this study is knowing and producing effervescent granules with the best formulations as a health drink; and knowing and determining the economic value and feasibility level production of effervescent granules as a busniess unit. The result of this study indicate that, based on the solubl

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Hasibuan, Nirmala Efri, and Sumartini Sumartini. "POTENSI EKSTRAK DAUN MANGROVE RHIZOPHORA MUCRONATA DAN AVICENNIA OFFICINALIS SEBAGAI BAHAN PEMBUATAN SERBUK EFFERVESCENT." JSIPi (Jurnal Sains dan Inovasi Perikanan) (Journal of Fishery Science and Innovation) 4, no. 2 (2020): 74. http://dx.doi.org/10.33772/jsipi.v4i2.12667.

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Rhizophora mucronata dan Avicennia officinalis merupakan jenis mangrove yang memiliki potensi kandungan bioaktif yang tinggi. Dalam penelitian ini ekstrak daun mangrove kering dimanfaatkan sebagai sumber zat aktif pada effervescent. Pembuatan granul effervescent ekstrak daun mangrove menggunakan metode granulasi basah. Granul effervescent dibuat dalam lima formulasi dengan memvariasikan kadar ekstrak daun mangrove. Granul effervescent ekstrak daun mangrove yang dihasilkan memiliki karakteristik berwarna kuning kecoklatan, pH 5.05-5.81, kadar air 2,042 - 2,809%, Waktu larut 62,33 - 91, 33 detik

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Cahyani, Mesya Pramesti Regita, Siti Rodiyah, Muhammad Angga Prasetyo, Dewi Rahmawati, Dzakiya Zhihrotulwida, and M. Fithrul Mubarak. "ARTIKEL REVIEW: KARAKTERISTIK DAN EVALUASI SEDIAAN TABLET EFFERVESCENT." HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan 4, no. 2 (2025): 82–96. https://doi.org/10.51878/healthy.v4i2.6038.

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ABSTRACT Effervescent tablets are a pharmaceutical dosage form that is increasingly popular due to their practicality, ease of consumption, and ability to improve medication adherence and absorption. The purpose of reviewing articles is to determine the characteristics and evaluation of effervescent tablet preparations, including formulations, physical properties and physical quality evaluation of effervescent tablets. The method used in writing this article is the 2019-2025 literature study search method. National and international scientific articles were reviewed and examined regarding the

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Wijaya, Andre, Farida Lanawati Darsono, and Kuncoro Foe. "Development of standardized green coffee bean extract (Coffea canephora) into effervescent granules as an antioxidant supplement." Pharmaciana 14, no. 3 (2024): 382–95. https://doi.org/10.12928/pharmaciana.v14i3.29237.

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This study aimed to obtain the optimum formula of effervescent granules of green coffee extract (EG-GCE) on its physical quality (flow speed, water content, and dissolving granule time test) and effectiveness as an antioxidant. The dried extract was obtained by percolation of green coffee with water and dried using a spray drier. The dry extract will be standardized for specific and non-specific. The dose of the dried extract of green coffee used in the granule effervescent was 250 mg pr sachet. EG-GCE was formulated using wet granulation method. Effervescent granules were tested for physical

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Herlinawati, Lina. "Mempelajari Pengaruh Konsentrasi Maltodekstrin dan Polivinil Pirolidon (PVP) terhadap Karakteristik Sifat Fisik Tablet Effervescent Kopi Robusta (Coffea robusta Lindl)." AGRITEKH (Jurnal Agribisnis dan Teknologi Pangan) 1, no. 01 (2020): 1–25. http://dx.doi.org/10.32627/agritekh.v1i01.17.

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Effervescent tablets are soft drink products that contain organic acids such as citric acid and sodium bicarbonate, which react quickly in water by releasing carbon dioxide. The purpose of this research is to increase the empowerment of coffee plants, namely Robusta coffee as a popular commodity, with Robusta coffee diversification into functional food products in the form of effervescent tablets. This study aims to determine whether there are variations in the concentration of maltodextrin and polyvinyl pyrrolidone (PVP) on the physical characteristics of robusta coffee effervescent tablets.

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Faidah, Anis, and Janatun Na'imah. "PEMBUATAN DAN EVALUASI GRANUL EFFERVESCENT VITAMIN C." JIFI (Jurnal Ilmiah Farmasi Imelda) 7, no. 2 (2024): 132–39. http://dx.doi.org/10.52943/jifarmasi.v7i2.1617.

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Vitamin C is a compound with the molecular formula and the chemical name 2-oxo-L-threo-hexono-1,4-lactone-2,3-enediol. Vitamin C can improve the immune system and as an antioxidant can prevent and treat infections and various other diseases, by fighting bacteria, viruses and fungal diseases. Vitamin C in the form of effervescent granules is an alternative to consuming vitamins for someone who has difficulty swallowing medication in tablets, pills or capsules. This research aims to determine the evaluation results of making vitamin C effervescent granules through several evaluations including d

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Pakhale, Nilesh V., S. B. Gondkar, and R. B. Saudagar. "Effervescent Floating Drug Delivery System: A review." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 836–38. http://dx.doi.org/10.22270/jddt.v9i3-s.2817.

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Effervescent floating drug delivery systems release gas CO2, thus reduce the density of the system and remain buoyant in the stomach 2 for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. In the present article we will discuss in detail about effervescent agent and mechanism of effervescent floating drug delivery system. Oral sustained release gastro-retentive dosage forms offer many advantages for drugs with the absorption from upper parts of the gastro intestinal

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Deshmukh, Komal* Narsale Somanath Salve Bhumika Chavan Rutuja. "A Review on Formulation and Evaluation of Effervescent Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4428–38. https://doi.org/10.5281/zenodo.15521939.

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Although there are certain drawbacks to oral dosage forms compared to alternative approaches, such as the possibility of drug absorption, these can be addressed by providing the medicine in a liquid form, potentially enabling the use of lower dosages. Oral dosage forms are the most often used form of medication. However, many medications' volatility in liquid dose form limits their use. Creating effervescent tablets or granules, which are typically employed in quick-release arrangements, is an alternative to creating a dosage form that might hasten the dispersion and degradation of medications

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Jamaludin, Wahyudin Bin, Nadia Masytoh, and Eka Fitri Susiani. "FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN GRANUL EFFERVESCENT DARI KOMBINASI EKSTRAK ETANOL 70% BUNGA ROSELLA (Hibiscus sabdariffa L.) DAN BUNGA TELANG (Clitoria ternatea L.)." Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 8, no. 1 (2023): 1–10. http://dx.doi.org/10.36387/jiis.v8i1.1065.

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Rosella (Hibiscus sabdariffa L.) and telang flower (Clitoria ternatea L.) contain anthocyanins which have antioxidant, so the researchers combined to use as effervescent granules. This study aims to determine the characteristics, and the antioxidant activity of effervescent granule combination of rosella and telang flower extract. Antioxidant activity testing using DPPH. The antioxidant activity of the combined thick extract was obtained 𝐼𝐶 50 7.5 ppm, after that it was made into an effervescent granule preparation in 4 formulas. The resut show that all formulas had a characteristic taste of a

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Olivia Laurent, Tia Triyanti, Dika Suranda, and Linda Chiuman. "Formulation and Evaluation of Effervescent Granules Ethanol Extract of Andaliman Fruit (Zanthoxylum acanthopodium DC) with Combination of Citric Acid-Tartaric Acid and Sodium Bicarbonate." Eureka Herba Indonesia 4, no. 4 (2023): 310–15. http://dx.doi.org/10.37275/ehi.v4i4.89.

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The combination of citric acid-tartaric acid and sodium bicarbonate in effervescent granules has an important role in providing an effervescent effect. Citric acid and tartaric acid are organic acids that can react with sodium bicarbonate when they come in contact with water. This reaction results in the release of carbon dioxide gas, which has a splitting effect and makes the effervescent granules dissolve rapidly in water. Research on the formulation and evaluation of effervescent granules of andaliman fruit ethanol extract with a combination of citric acid-tartaric acid and sodium bicarbona

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Noval, Noval, Ilham Kuncahyo, Adam Ferdian Sigit Pratama, Syafira Nabillah, and Roosma Hatmayana. "Formulasi Sediaan Tablet Effervescent dari Ekstrak Etanol Tanaman Bundung (Actionoscirpus grossus) sebagai Antioksidan." Jurnal Surya Medika 7, no. 1 (2021): 128–39. http://dx.doi.org/10.33084/jsm.v7i1.2649.

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Bundung (Actinoscirpus grossus) is a plant that contains an antioxidant compound proven in previous studies, which has a moderate antioxidant or IC50 by 128 ppm. Antioxidant compounds can reduce the negative impact of oxidants, including metal binding enzymes and proteins. Antioxidant compounds act by donating one electron to the oxidant compound to inhibit oxidants activity. The purpose of this study was to formulate the Bundung plant extract into effervescent tablets, obtain effervescent samples that are physically stable, and can be used as antioxidants to inhibit free radicals in the body.

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Sultana, Rehana, Krishna Sarker, and Sakina Sultana. "Preparation and Evaluation of Paracetamol Effervescent Tablets under Normal and Exaggerated Storage Conditions." Bangladesh Pharmaceutical Journal 17, no. 1 (2015): 75–78. http://dx.doi.org/10.3329/bpj.v17i1.22320.

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A single blind study was conducted to prepare and evaluate paracetamol effervescent tablets. Potency, content uniformity, diameter, thickness and crushing strength of the prepared tablets were used as the bench mark parameters for quality assessment. Our results showed that all parameters met official values except for friability. The performance of the tablets in terms of duration of effervescence was investigated under high stresses of humidity as well as at low and high temperatures. The duration of the investigational period lasted for 3 days and results showed an increase in effervescence

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Suhesti, Tuti Sri, Warsinah Warsinah, and Pitra Wulandari. "Optimizing effervescent granules of butterfly pea (Clitoria ternatea L) flower ethanol extract as antioxidant." Acta Pharmaciae Indonesia : Acta Pharm Indo 10, no. 1 (2022): 5803. http://dx.doi.org/10.20884/1.api.2022.10.1.5803.

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Background: Butterfly pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity.  Objective: This research aims to produce the effervescent granule preparations of the butterfly pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid.  Methods: Butterfly pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of g

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Madhavi, Nupur, Dharmender Kumar, Subh Naman, et al. "Formulation and Evaluation of Novel Herbal Formulations Incorporated with Amla Extract for Improved Stability." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 212–21. http://dx.doi.org/10.22270/jddt.v9i4.3029.

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The objective of the present study was to formulate effervescent and fast dispersible granules by incorporating the fruit extract of Emblica officinalis as an alternate of liquid herbal juices available in market. Amla juice was extracted manually and then subjected to preliminary phytochemical screening which indicates the presence of alkaloids, glycosides, flavonoids, carbohydrates, phenolic compounds, proteins and phytosterols. Lyophilized amla powder was used to formulate effervescent and fast dispersible granules which were further optimized on the basis of concentration of superdisintegr

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Apsari, Puput Andi, Dewi Nur Eka Sari, Aris Perdana Kusuma, and Oktavia Indrati. "Effervescent Tablet Formulation Melinjo Seed Extract (Gnetum gnemon L.) Using PEG 6000 As Lubricant and Citric Acid - Tartaric Acids As Acid Sources." JURNAL EKSAKTA 18, no. 1 (2018): 30–41. http://dx.doi.org/10.20885/eksakta.vol18.iss1.art4.

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Melinjo seeds (Gnetum gnemonÂ L.) have antioxidant properties one of which is from phenol compounds. However, there is no pharmaceutical dosage form of melinjo seeds especially effervescent tablet. The purpose of this research was to determine the best variation of citric-tartaric acid and PEG 6000 from effervescent tablet of melinjo seed extract. The effervescent tablet of melinjo seed extract were formulated with variation of citric-tartaric acid 25%:75%, 65%:35%, 50%:50%, 20%:80% and PEG 6000 0%, 2%, 3%, up to 5%. The effervescent tablet were made by melting parts of acids and bases, added

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Syahrina, Dahlia, and Noval Noval. "Optimasi Kombinasi Asam Sitrat dan Asam Tartrat sebagai Zat Pengasam pada Tablet Effervescent Ekstrak Ubi Jalar Ungu (Ipomoea batatas L)." Jurnal Surya Medika 7, no. 1 (2021): 156–72. http://dx.doi.org/10.33084/jsm.v7i1.2651.

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Purple sweet potato has the content of anthocyanin compounds that are efficacious as antioxidants. To deliver these efficacious compounds, formulations of effervescent tablets are required as antioxidants with a combination of citric acid and tartrate acid to accelerate the solubility of the drug. The research aims to optimize the combination of citric acid and tartrate acid as a sourgent on effervescent tablets of purple sweet potato extract using the simplex lattice design method. The manufacture of tablets using a direct pumping method with effervescent powder evaluation includes flow rate

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Liang, Qiang, Yan Feng Li, Guo Cai Yao, and Xue Fei Xing. "A Study on the New Portable Effervescent Atomized Water Mist Equipment." Applied Mechanics and Materials 392 (September 2013): 116–21. http://dx.doi.org/10.4028/www.scientific.net/amm.392.116.

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A new effervescent atomized water mist fire extinguishing equipment was developed by combining the characters of water mist and effervescent atomization. A series of wood crib and gasoline pool fire suppression experiments were performed using the equipment. The fire extinguishment time, temperature and radiation heat flux of the flame were measured, and then the process of putting out different type fire was analyzed. A wood crib fire of 0.6A can be put out in 180 seconds using water mist produced by effervescent atomization equipment. Only 38 seconds was taken to suppress a gasoline fire.

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Cunha-Filho, Marcilio Sérgio Soares da, Pricila Castilho Gustmann, Felipe Sanches Garcia, Eliana Martins Lima, and Lívia Cristina Lira de Sá-Barreto. "Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design." Brazilian Journal of Pharmaceutical Sciences 50, no. 2 (2014): 243–50. http://dx.doi.org/10.1590/s1984-82502014000200002.

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The medicinal plant Maytenus ilicifolia is a commonly used phytomedicine for the treatment of gastritis. The high dose required and low density of these extracts make necessary a daily intake of several capsules, hindering adherence to the medication. The purpose of this work was to develop a suitable dosage form for the administration of Maytenus ilicifolia using effervescent granules. A 23 factorial design was used to study the physical characteristics of the granules (particle size distribution, repose angle, Carr index, scanning electron microscopy and disintegration time). Moisture stabil

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Djamal Julia Megawati, Muh Hidayat, and Miftahurrahmah Pansariang. "Formulasi dan Evaluasi Sediaan Granul Effervescent Ekstrak Kulit Buah Sukun (Artocarpus altilis)." OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan 3, no. 1 (2025): 299–311. https://doi.org/10.61132/obat.v3i1.1057.

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Breadfruit (Artocarpus altilis) is a kind of consumable plant, generally peoples will process the fruit and discharge the peel. Effervescent granule is a practice of powder preparation. This study aim to create the effervescent granulation preparation to making the peel if breadfruit will easier to consumen with extract concentrations : F1 (5%), F2 (10%), and F3 (15%) and determine the characteristics of the resulting preparation. Making effervescent granules using the alkaline granulation method. Then the resulting preparation is evaluated by testing, including organoleptic test, pH, flow rat

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Sifaiya, Laily, and Rahmawaty Hasan. "Formulasi dan Evaluasi Fisik Serbuk Effervescent Ekstrak Etanol 96% Daun Kelor (Moringa oleifera)." Jurnal Farmasi Tinctura 5, no. 1 (2023): 10–18. http://dx.doi.org/10.35316/tinctura.v5i1.3974.

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Serbuk effervescent daun kelor merupakan sediaan obat tradisional yang tepat dalam pengolahandaun kelor untuk meningkatkan minat konsumsi masyarakat. Tujuan penelitian ini adalah mendapatkanformula serbuk effervescent daun kelor yang baik berdasarkan karakteristik evaluasi fisik sediaan. Metodepenelitian terdiri dari ekstraksi daun kelor, formulasi dan evaluasi fisik sediaan. Terdapat 2 formuladengan perbandingan komponen asam dan basa (asam sitrat: asam tartrat: natrium bikarbonat) yaitu0,75:0,45:1 sebagai formula 1 dan 1:0,2:1 sebagai formula 2. Evaluasi fisik sediaan terdiri dari ujiorganol

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Dami, Theovilla R. Rianty. "STUDI PEMBUATAN TABLET EFFERVESCENT DENGAN EKSTRAK BUNGA MAWAR MERAH (Rosa sp.) PADA PASCA POTONG BUNGA MAWAR DAN JENIS FILLER (NaHCO3, KHCO3, CaCO3)." AGRICA 4, no. 1 (2020): 9–37. http://dx.doi.org/10.37478/agr.v4i1.464.

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Red roses (Rosa sp) are a decorative plant species. Their petals contain the pigment anthocyanin, which is classified as a flavonoid and is able to capture free radicals. Due to their popularity, roses are an abundant resource and can be processed into effervescent drink tablets. This study aims to investigate the influence of time after harvest and filler type on the quality of the red rose extract powder, on effervescent tablets made from the said extract and on effervescent drink quality. The study was conducted in two stages. Phase I tested the quality of pigment extract of hybrid varietie

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Haryono, Ika Avrilina, and Noval Noval. "Formulasi dan Evaluasi Tablet Effervescent dari Ekstrak Buah Tampoi (Baccaurea macrocarpa)." Jurnal Surya Medika 7, no. 2 (2022): 34–44. http://dx.doi.org/10.33084/jsm.v7i2.3201.

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Tampoi is one of the many plants found in East Kalimantan, has secondary metabolic content in the form of saponins, flavonoids, and alkaloids, and has antioxidant activity. The antioxidants produced by the human body are not sufficient to fight free radicals, therefore the body requires the intake of antioxidants from the outside, so to help increase public interest in consumption, researchers are interested in making preparations in the form of extracts and formulated as effervescent tablets from tampoi fruit extract which are useful as antioxidants and increase immunity. The purpose of this

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Sari, Lusia Oktora Ruma Kumala, Tiara Berlianti, and Eka Deddy Irawan. "Optimasi Formula Tablet Effervescent Dispersi Padat Meloksikam Menggunakan Desain Faktorial." Pustaka Kesehatan 6, no. 2 (2018): 225. http://dx.doi.org/10.19184/pk.v6i2.7571.

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 An effervescent tablet of meloxicam solid dispersion has been developed for geriatric patients who have difficulty swallowing. The objective of this research was to know the optimum concentration of citric acid and sodium bicarbonate which produce the best effervescent tablet. A 2² factorial design was applied to investigate the effect of two factors: concentration of citric acid and sodium bicarbonate (effervescent materials) on hardness, dissolve time, and %drug released t30. Citric acid (6-18 mg) was used as acid source and sodium bicarbonate (18-105 mg) was used as base source. Soft

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Wasim, Ahamed S., Shankaraswamy Jadala, Sathish Gokenapally, Nagaraju Kattula, and Sridevi Gajula. "Physicochemical evaluation of Olive (Olea europea) fruit, halophyte (Salicornia herbacea L) plant salts and bamboo (Bambos arundinaceae) silica salts based effervescent tablets with promoting edible organic acids and carbonates." Journal of Applied and Natural Science 16, no. 3 (2024): 1087–95. http://dx.doi.org/10.31018/jans.v16i3.5641.

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Maintainance of extracellular volume and water balance is important in cellular metabolism and these properties confer to sodium profile, but overconsumption of sodium causes risk to health. The present study aimed to develop and evaluate fast-dissolving effervescent tablets using a novel two-step wet granulation method, incorporating Olive (Olea europaea), halophyte marsh plant (Salicornia herbacea L.) and bamboo silica salts natural ingredients and edible organic acids viz. citric acid, malic acid, tartaric acid, apple cider vinegar powder, fumaric acid and alkalizing agents like sodium bica

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Forestryana, Dyera, Yunitha Hestiarini, and Aristha Novyra Putri. "FORMULASI GRANUL EFFERVESCENT EKSTRAK ETANOL 90% BUAH LABU AIR (Lagenaria siceraria) SEBAGAI ANTIOKSIDAN DENGAN VARIASI GAS GENERATING AGENT." Jurnal Ilmiah Ibnu Sina (JIIS) Ilmu Farmasi dan Kesehatan 5, no. 2 (2020): 220–29. http://dx.doi.org/10.36387/jiis.v5i2.457.

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Water pumpkin (Lagenaria siceraria) is a vegetable that contains secondary metabolites that are beneficial to health. Its use as a vegetable is less attractive to the people so that to increase its utilization, dosage forms are made that can attract public interest, one of which is effervescent granules. Effervescent granules are the most popular dosage form because they can serve in fresh drinks. This study aims to determine the effect of variations in the concentration of acids (citric acid-tartaric acid) and base (sodium bicarbonate) on the physical properties of the formula. The water pump

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Ratrinia, P. W., Sumartini, and N. E. Hasibuan. "The effect of addition dfferent types of binders to the effervescent chemical characteristics of Sonneratia casolaris fruits." IOP Conference Series: Earth and Environmental Science 967, no. 1 (2022): 012049. http://dx.doi.org/10.1088/1755-1315/967/1/012049.

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Abstract Sonneratia caseolaris fruit that has not been widely explored is as an effervescent raw material. The purpose of this study was to determine the effervescent chemical characteristics of Sonneratia caseolaris fruit with the addition of several different types of binders. The research design used in this study was a Completely Randomized Design using four treatments using different binders, namely Polyvinyl Pyrrolidone (PVP), gelatin, Pulvis Gummi Arabicum (PGA), and maltodextrin. The test method used in this research is the analysis of water content, pH value, vitamin C, antioxidants,

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Widjayanti, Vinsensia Ivana, and Iwan Setiawan. "Formulasi Tablet Effervescent Ekstrak Sirih Cina (Peperomia pellucida L.) Dan Uji Aktivitas Terhadap Antibakteri Staphylococcus aureus." Pharmacon: Jurnal Farmasi Indonesia 19, no. 2 (2022): 115–25. http://dx.doi.org/10.23917/pharmacon.v19i2.18338.

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Chinese Betel herb (Peperomia pellucida L.) has flavonoid and saponin content compounds that can inhibit bacterial growth. The innovation of effervescent tablets used as disinfectants is not widely known in the Indonesian market. This preparation has the advantage of being easy to manufacture as a disinfectant. Chinese betel herb extract is formulated into an effervescent tablet preparation. This study aims to determine the influence on variations in the levels of binders and fillers in the physical properties of effervescent tablet preparations and determine the activity in the effervescent t

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Ma, Yan, Yali Lian, Xintao Meng, et al. "Process Optimization of Sea Buckthorn Fruit Powder Effervescent Tablets by Random Centroid Methodology Combined with Fuzzy Mathematical Sensory Evaluation." Processes 11, no. 9 (2023): 2639. http://dx.doi.org/10.3390/pr11092639.

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Solid beverages of effervescent tablets have good taste and portable features and are favored by consumers, but product quality and nutrition cannot meet the need of increasing nutritional requirements. Sea buckthorn fruit has a special flavor and nutrient-rich characteristics, but the related products of effervescent tablets have not been developed. In this paper, different additive contents (sea buckthorn fruit powder, erythritol, disintegrant, maltodextrin, polyvinylpyrrolidone (PVP)) were optimized using the random centroid method; the obtained effervescent effect sensory evaluation charac

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