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Articles de revues sur le sujet « EOB Model »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Kim, Song Chol, Song Guk Han, Yong Il Song, Jin Sim Kim, and Myong Gun Hong. "Well-Testing Model for Dual-Porosity Reservoir considering Stress-Sensitivity and Elastic Outer Boundary Condition." Geofluids 2023 (November 16, 2023): 1–16. http://dx.doi.org/10.1155/2023/4658604.

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Stress sensitivity and the elastic outer boundary (EOB) condition have a great effect on the analysis of the characteristics of the fluid flow in a reservoir. When researchers analyzed the characteristics of the fluid flow, they have considered the stress sensitivity and the EOB condition separately but have not considered them simultaneously. Therefore, errors are inevitable during the analysis of well testing. The main object of this work is to present a well-testing model for stress-sensitivity dual-porosity reservoir (DPR) with EOB to improve the accuracy of the analysis of well-testing da

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Oba, Atsushi, Tomoyuki Taguchi, Naoto Fujikawa, et al. "Impact of EOB-MRI on the outcome of patients with pancreatic cancer in real-world settings." Journal of Clinical Oncology 42, no. 16_suppl (2024): e16298-e16298. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e16298.

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e16298 Background: Contrast-enhanced computed tomography (CE-CT) is a commonly used imaging modality for the preoperative detection of local extension and distant metastasis in patients (pts) with pancreatic cancer (PaC). There have been cases where surgical treatment was deemed unsuitable due to unexpected distant metastases discovered during surgery, which had not been detected by CE-CT. While studies have reported gadoxetate disodium-enhanced MRI (EOB-MRI) improves the detection of liver metastases, it is not clear whether adding EOB-MRI to CE-CT provides clinical benefits, e.g. improved ou

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Debona, Daniel, Angela Pivotto, Alexsandro J. Tetzlaff, et al. "Essential Oil of Baccharis dracunculifolia (Asteraceae) Decreases Alternaria Rot in Pitahaya." Journal of Agricultural Science 13, no. 7 (2021): 10. http://dx.doi.org/10.5539/jas.v13n7p10.

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Alternaria rot, caused by Alternaria alternata, is one of the most destructive diseases of pitahaya (Hylocereus spp.). We investigated the effect of the essential oil of Baccharis dracunculifolia (Asteraceae) (EOB) in the control of A. alternata. Two studies were performed in Petri dishes containing potato dextrose agar medium amended with concentrations of the EOB ranging from 5 to 1,000 &micro;g mL-1 (first study) and from 30 to 2,000 &micro;g mL-1. The diameter of the fungal colony was recorded daily. These data were used to calculate the the area under the mycelial growth progress

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Oba, Atsushi, Tomoyuki Taguchi, Naoto Fujikawa, et al. "Impact of EOB-MRI on the outcome of patients with pancreatic cancer in real-world settings." Journal of Clinical Oncology 42, no. 23_suppl (2024): 88. http://dx.doi.org/10.1200/jco.2024.42.23_suppl.88.

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88 Background: Contrast-enhanced computed tomography (CE-CT) is a commonly used imaging modality for the preoperative detection of local extension and distant metastasis in patients (pts) with pancreatic cancer (PaC). There have been cases where surgical treatment was deemed unsuitable due to unexpected distant metastases discovered during surgery, which had not been detected by CE-CT. While studies have reported gadoxetate disodium-enhanced MRI (EOB-MRI) improves the detection of liver metastases, it is not clear whether adding EOB-MRI to CE-CT provides clinical benefits, e.g. improved outcom

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Vicka, Vaidas, Elija Januskeviciute, Justina Krauklyte, et al. "Determinants of Increased Effort of Breathing in Non-Intubated Critical COVID-19 Patients." Medicina 58, no. 8 (2022): 1133. http://dx.doi.org/10.3390/medicina58081133.

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Background and objectives: Acute respiratory distress syndrome (ARDS) is the most common complication occurring in COVID-19 patients admitted to the ICU. Given the increased respiratory work of these patients, it is necessary to evaluate their actual breathing efforts. The aim of this study is to report the incidence and determinants of increased effort of breathing (EOB) in critical COVID-19 patients. Materials and Methods: This was a retrospective study of COVID-19 patients admitted to the ICU during the year of 2020. Respiratory rate (RR) was chosen as an indicator of EOB. The cut-off value

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Fehrenbach, Uli, Siyi Xin, Alexander Hartenstein, et al. "Automatized Hepatic Tumor Volume Analysis of Neuroendocrine Liver Metastases by Gd-EOB MRI—A Deep-Learning Model to Support Multidisciplinary Cancer Conference Decision-Making." Cancers 13, no. 11 (2021): 2726. http://dx.doi.org/10.3390/cancers13112726.

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Background: Rapid quantification of liver metastasis for diagnosis and follow-up is an unmet medical need in patients with secondary liver malignancies. We present a 3D-quantification model of neuroendocrine liver metastases (NELM) using gadoxetic-acid (Gd-EOB)-enhanced MRI as a useful tool for multidisciplinary cancer conferences (MCC). Methods: Manual 3D-segmentations of NELM and livers (149 patients in 278 Gd-EOB MRI scans) were used to train a neural network (U-Net architecture). Clinical usefulness was evaluated in another 33 patients who were discussed in our MCC and received a Gd-EOB MR

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Tanpowpong, Natthaporn, and Teerasak Phewplung. "Brief communication (Original). Correlation between liver signal intensity in hepatobiliary phase of Gd-EOB-DTPA enhancement and liver function reserves." Asian Biomedicine 8, no. 3 (2014): 411–15. http://dx.doi.org/10.5372/1905-7415.0803.308.

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Abstract Background: Gadolinium diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) is a developed agent with preferential uptake by hepatocytes. A rapid and specific hepatocyte uptake with biliary excretion was observed of approximately 50% of the injected dose. The amount of contrast uptake is thought to be related to reserve liver function. Objectives: To evaluate correlation between liver signal intensity in the hepatobiliary phase of Gd-EOB-DTPA and reserved liver function by using the model score for end-stage liver disease (MELD). Methods:All patients who underwent magnetic resonance (MR)

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Wei, Jingwei, Hanyu Jiang, Mengsu Zeng, et al. "Prediction of Microvascular Invasion in Hepatocellular Carcinoma via Deep Learning: A Multi-Center and Prospective Validation Study." Cancers 13, no. 10 (2021): 2368. http://dx.doi.org/10.3390/cancers13102368.

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Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). Preknowledge of MVI would assist tailored surgery planning in HCC management. In this multicenter study, we aimed to explore the validity of deep learning (DL) in MVI prediction using two imaging modalities—contrast-enhanced computed tomography (CE-CT) and gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI). A total of 750 HCCs were enrolled from five Chinese tertiary hospitals. Retrospective CE-CT (n = 306, collected between March, 2013 and July, 2019) and EOB-MRI (n

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You, Myung-Won, Hyoung Jung Kim, Hyeong-Seok Lim, et al. "Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model." Contrast Media & Molecular Imaging 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/6321316.

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Objectives. To determine whether the pharmacokinetic parameters of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model. Methods. A total of 56 eight-week-old male Sprague-Dawley rats were divided into the following groups: control group without hepatectomy (n=16), 70% hepatectomy group (n=14), and 90% hepatectomy group (n=26). On postoperative day 2, Gd-EOB-DTPA (0.1 mmol/kg) was injected intravenously and serial blood samples were obtained. Pharmacokinetic analysis was performed using a noncompartmental method. Statistical analysis was performed using one-way

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Huang, Mengqi, Bing Liao, Ping Xu, et al. "Prediction of Microvascular Invasion in Hepatocellular Carcinoma: Preoperative Gd-EOB-DTPA-Dynamic Enhanced MRI and Histopathological Correlation." Contrast Media & Molecular Imaging 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/9674565.

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Objective. To investigate the imaging features observed in preoperative Gd-EOB-DTPA-dynamic enhanced MRI and correlated with the presence of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients. Methods. 66 HCCs in 60 patients with preoperative Gd-EOB-DTPA-dynamic enhanced MRI were retrospectively analyzed. Features including tumor size, signal homogeneity, tumor capsule, tumor margin, peritumor enhancement during mid-arterial phase, peritumor hypointensity during hepatobiliary phase, signal intensity ratio on DWI and apparent diffusion coefficients (ADC), T1 relaxation time

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Jayappa, Kallesh D., Andrea Joyner, Archana Thakur, and Owen A. O’Connor. "Abstract 7185: Optimization of an epigenetic based combination platform for patients with peripheral t cell lymphoma." Cancer Research 85, no. 8_Supplement_1 (2025): 7185. https://doi.org/10.1158/1538-7445.am2025-7185.

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Abstract Introduction: Our previous work demonstrated that combinations of HDAC and DNMT3 inhibitors were synergistic in preclinical models of T-cell lymphoma, and produced compelling activity in patients with relapsed or refractory disease. This combination was identified based on high-throughput chemical screening seeking to identify synthetically lethal combinations in a disease directed fashion. Here, we present a similar approach to rationally identify a third drug to complement the epigenetic-based combinations established to date. Results: First, we optimized the schedule of an HDACi [r

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Lee, Yi-Hsueh, Menq-Rong Wu, and Jong-Kai Hsiao. "Organic Anion Transporting Polypeptide 1B1 Is a Potential Reporter for Dual MR and Optical Imaging." International Journal of Molecular Sciences 22, no. 16 (2021): 8797. http://dx.doi.org/10.3390/ijms22168797.

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Membrane proteins responsible for transporting magnetic resonance (MR) and fluorescent contrast agents are of particular importance because they are potential reporter proteins in noninvasive molecular imaging. Gadobenate dimeglumine (Gd-BOPTA), a liver-specific MR contrast agent, has been used globally for more than 10 years. However, the corresponding molecular transportation mechanism has not been validated. We previously reported that the organic anion transporting polypeptide (OATP) 1B3 has an uptake capability for both MR agents (Gd-EOB-DTPA) and indocyanine green (ICG), a clinically ava

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Bilton, Shawna, and Zhi Sheng. "DDDR-12. THE ROLE OF CASEIN KINASE 1 EPSILON IN TEMOZOLOMIDE SENSITIVITY IN GLIOBLASTOMA STEM CELLS." Neuro-Oncology 24, Supplement_7 (2022): vii101. http://dx.doi.org/10.1093/neuonc/noac209.377.

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Abstract A major hurdle in effectively treating glioblastoma is the resistance to current chemotherapy temozolomide (TMZ), exhibited intrinsically in glioblastoma stem cells (GSCs). GSCs are a population of tumor cells that are self-renewing, highly resilient and capable of forming genetically heterogeneous and difficult-to-treat tumors. Therefore, overcoming TMZ resistance holds significant promise in the treatment of glioblastoma. Casein kinase 1 ε (CK1ε) has been identified as a stem cell factor that is important for GSCs to self-renew. However, whether CK1ε confers TMZ resistance in GSCs r

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Zhuang, Xin-hui, Dong-ying Su, Miao-er Li, Jinzhan Su, Shu-feng Fan, and Fang Wu. "The value of Gd-EOB-DTPA-enhanced MRI in the differential diagnosis of HCC with hyperintensity on HBP and FNH." Medicine 104, no. 26 (2025): e43106. https://doi.org/10.1097/md.0000000000043106.

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The aim was to investigate the differential diagnostic potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) features and establish a nomogram model for distinguishing hepatocellular carcinoma (HCC) from focal nodular hyperplasia (FNH) presenting with hyperintensity on the hepatobiliary phase (HBP). This retrospective study enrolled 80 patients with pathologically confirmed HCC or FNH who underwent Gd-EOB-DTPA-enhanced MRI between January 2017 and December 2020. All lesions exhibited hyperintensity on HBP. Morphological

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Mattson, J. K., A. T. DeVries, S. M. McGuire, J. Krebs, E. E. Louis, and N. M. Loskutoff. "247 SUCCESSFUL ARTIFICIAL INSEMINATION IN THE CORN SNAKE (ELAPHE GUTATTA), USING FRESH AND COOLED SEMEN." Reproduction, Fertility and Development 19, no. 1 (2007): 240. http://dx.doi.org/10.1071/rdv19n1ab247.

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The purpose of this investigation was to develop a non-invasive technique to artificially inseminate snakes using the corn snake, Elaphe gutatta, as the model representative for this taxon. Semen was collected by first applying pressure to the lower abdomen in a continuous distal motion toward the cloaca to remove any feces or urates. The cloaca was then gently washed using phosphate-buffered saline, and a more localized pressure was applied to each side of the vent to evert the hemipenes and, subsequently, the ejaculate. The semen was collected using a sterile transfer pipette and placed into

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Mi, Xu, Gan, Chen, Qiao, and Zhu. "How to Motivate Employees’ Environmental Citizenship Behavior through Perceived Interpersonal Circle Power? A New Perspective from Chinese Circle Culture." Sustainability 11, no. 17 (2019): 4549. http://dx.doi.org/10.3390/su11174549.

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Employees’ spontaneous environmental citizenship behavior (ECB) is a key factor in facilitating the low-carbon transition of enterprises. However, little research has focused on the impact of interpersonal interactions on ECB. To explore how ECB is affected by special interpersonal circles in Chinese organizations, we propose a new concept: perceived interpersonal circle power (PICP). From the two dimensions of PICP, leader-oriented perceived interpersonal circle power (PICP-L) and colleague-oriented perceived interpersonal circle power (PICP-C), we establish a mechanism model to explore the e

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Chen, Jian-Ping, Ri-Hui Yang, Tian-Hui Zhang, Li-An Liao, Yu-Ting Guan, and Hai-Yang Dai. "Pre-operative enhanced magnetic resonance imaging combined with clinical features predict early recurrence of hepatocellular carcinoma after radical resection." World Journal of Gastrointestinal Oncology 16, no. 4 (2024): 1192–203. http://dx.doi.org/10.4251/wjgo.v16.i4.1192.

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BACKGROUND Indentifying predictive factors for postoperative recurrence of hepatocellular carcinoma (HCC) has great significance for patient prognosis. AIM To explore the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance imaging (MRI) combined with clinical features in predicting early recurrence of HCC after resection. METHODS A total of 161 patients with pathologically confirmed HCC were enrolled. The patients were divided into early recurrence and non-early recurrence group based on the follow-up results. The clinical, laboratory,

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Kowada, Akiko. "Risk-stratified hepatocellular carcinoma screening according to the degree of obesity and progression to cirrhosis for diabetic patients with metabolic dysfunction-associated steatotic liver disease (MASLD) in Japan: a cost-effectiveness study." BMJ Open 14, no. 11 (2024): e080549. http://dx.doi.org/10.1136/bmjopen-2023-080549.

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ObjectiveTo evaluate the cost-effectiveness of risk-stratified hepatocellular carcinoma (HCC) screening in diabetic patients with metabolic dysfunction-associated steatotic liver disease (MASLD).DesignA state-transition model from a healthcare payer perspective on a lifetime horizon.SettingJapan.PopulationA hypothetical cohort of 50-year-old diabetic patients with MASLD risk-stratified according to degree of obesity and progression to cirrhosis. Metabolic dysfunction-associated steatotic liver (MASL), metabolic dysfunction-associated steatohepatitis (MASH) and MASH cirrhosis are progressive ma

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Segers, J??r??me, G??raldine Le Duc, Catherine Laumonier, Ir??ne Tropr??s, Luce Vander Elst, and Robert N. Muller. "Evaluation of Gd-EOB-DTPA Uptake in a Perfused and Isolated Mouse Liver Model." Investigative Radiology 40, no. 9 (2005): 574–82. http://dx.doi.org/10.1097/01.rli.0000174474.43772.58.

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Liu, Xiaolin, Zhoujian Cao, and Zong-Hong Zhu. "A higher-multipole gravitational waveform model for an eccentric binary black holes based on the effective-one-body-numerical-relativity formalism." Classical and Quantum Gravity 39, no. 3 (2022): 035009. http://dx.doi.org/10.1088/1361-6382/ac4119.

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Abstract We have previously constructed a waveform model, S E O B N R E , for spinning binary black hole (BBH) moving along eccentric orbit based on effective-one-body (EOB) formalism. In the current paper, we update S E O B N R E waveform model in the following three respects. Firstly, we update the EOB dynamics from S E O B N R v 1 to S E O B N R v 4 . Secondly we properly treat the Schott term which has been ignored in previous S E O B N R E . Thirdly, we construct a new factorized waveform including (l, |m|) = (2, 2), (2, 1), (3, 3), (4, 4) modes based on EOB formalism, which is valid for

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Cavaliere, Alessandra, Katrin C. Probst, Stephen J. Paisey, et al. "Radiosynthesis of [18F]-Labelled Pro-Nucleotides (ProTides)." Molecules 25, no. 3 (2020): 704. http://dx.doi.org/10.3390/molecules25030704.

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Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success. Despite the translation of ProTide technology into the clinic, there remain unresolved in vivo pharmacokinetic and pharmacodynamic questions. Positron Emission Tomography (PET) imaging using [18F]-labelled model ProTides could directly address key mechanistic questions and predict response to ProTide therapy. Here we report the first radiochemical synthesis of [18F]ProTi

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Granata, Vincenza, Roberta Fusco, Federica De Muzio, et al. "Radiomics and Machine Learning Analysis Based on Magnetic Resonance Imaging in the Assessment of Colorectal Liver Metastases Growth Pattern." Diagnostics 12, no. 5 (2022): 1115. http://dx.doi.org/10.3390/diagnostics12051115.

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To assess Radiomics and Machine Learning Analysis in Liver Colon and Rectal Cancer Metastases (CRLM) Growth Pattern, we evaluated, retrospectively, a training set of 51 patients with 121 liver metastases and an external validation set of 30 patients with a single lesion. All patients were subjected to MRI studies in pre-surgical setting. For each segmented volume of interest (VOI), 851 radiomics features were extracted using PyRadiomics package. Nonparametric test, univariate, linear regression analysis and patter recognition approaches were performed. The best results to discriminate expansiv

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HÖGEMANN, DAGMAR, ANDREAS BAUMANN, DIRK ROCKER, AUGUSTINUS BADER, and MICHAEL GALANSKI. "In Vitro Model of the Human Liver Parenchyma to Study Hepatotoxic Side Effects of Dy-EOB-DTPA." Investigative Radiology 35, no. 6 (2000): 373–79. http://dx.doi.org/10.1097/00004424-200006000-00006.

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Feng, Shi-Ting, Yingmei Jia, Bing Liao, et al. "Preoperative prediction of microvascular invasion in hepatocellular cancer: a radiomics model using Gd-EOB-DTPA-enhanced MRI." European Radiology 29, no. 9 (2019): 4648–59. http://dx.doi.org/10.1007/s00330-018-5935-8.

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Chudakov, D. B., O. D. Kotsareva, D. S. Tsaregorotseva, E. I. Kashirina та G. V. Fattakhova. "Effect of β-alanine on humoral immune response in low-dose allergy model". Medical Immunology (Russia) 23, № 1 (2021): 127–36. http://dx.doi.org/10.15789/1563-0625-eob-2008.

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At the present time, the efforts of many research groups around the world are aimed at finding new factors triggering the allergic sensitization process linked with IgE synthesis to harmless allergens. According to the recent data, production of tissue cytokines is induced in tissue cells by alarmins, thus, in turn, eliciting pro-allergic immune response. Previously we have shown that β-alanine could be a potential alarmin capable to stimulate production of tissue cytokines. The aim of this work was to determine the impact of β-alanine on humoral immune response in low-dose allergy model. BALB

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Bäumler, Wolf, Philipp Wiggermann, Lukas Lürken, et al. "Early Detection of Local Tumor Progression after Irreversible Electroporation (IRE) of Hepatocellular Carcinoma Using Gd-EOB-DTPA-Based MR Imaging at 3T." Cancers 13, no. 7 (2021): 1595. http://dx.doi.org/10.3390/cancers13071595.

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This single-center retrospective study was conducted to improve the early detection of local tumor progression (LTP) after irreversible electroporation (IRE) of a hepatocellular carcinoma (HCC) using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-based 3T MR imaging and to identify helpful signal characteristics by comparing 23 patients with and 60 patients without LTP. To identify the differences in the sensitivity of MRI sequences, the specificity, positive prediction value, negative prediction value (NPV) and diagnostic odds ratio were calculated. A chi-squared te

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Luo, Yong, Wei Ren, Yongmei Huang, et al. "Feedforward Control Based on Error and Disturbance Observation for the CCD and Fiber-Optic Gyroscope-Based Mobile Optoelectronic Tracking System." Electronics 7, no. 10 (2018): 223. http://dx.doi.org/10.3390/electronics7100223.

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In the mobile optoelectronic tracking system (MOTS) based on charge-coupled device (CCD) and fiber-optic gyroscope (FOG), the tracking performance (TP) and anti-disturbance ability (ADA) characterized by boresight error are of equal importance. Generally, the position tracking loop, limited by the image integration time of CCD, would be subject to a non-negligible delay and low-sampling rate, which could not minimize the boresight error. Although the FOG-based velocity loop could enhance the ADA of the system, it is still insufficient in the case of some uncertain disturbances. In this paper,

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Sun, X., X. Jiang, X. Li, L. Bu, and D. Wang. "Gd-EOB-DTPA MRI Imaging and Apoptosis Research in Orthotopic Rats Model of Hepatocellular Carcinoma after Stereotactic Radiotherapy." International Journal of Radiation Oncology*Biology*Physics 105, no. 1 (2019): E229. http://dx.doi.org/10.1016/j.ijrobp.2019.06.1993.

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Verloh, Niklas, Carolina Rio Bartulos, Kirsten Utpatel, et al. "Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial." Diagnostics 13, no. 18 (2023): 3014. http://dx.doi.org/10.3390/diagnostics13183014.

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In the context of liver surgery, predicting postoperative liver dysfunction is essential. This study explored the potential of preoperative liver function assessment by MRI for predicting postoperative liver dysfunction and compared these results with the established indocyanine green (ICG) clearance test. This prospective study included patients undergoing liver resection with preoperative MRI planning. Liver function was quantified using T1 relaxometry and correlated with established liver function scores. The analysis revealed an improved model for predicting postoperative liver dysfunction

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Le Tiec, Alexandre. "The overlap of numerical relativity, perturbation theory and post-Newtonian theory in the binary black hole problem." International Journal of Modern Physics D 23, no. 10 (2014): 1430022. http://dx.doi.org/10.1142/s0218271814300225.

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Inspiralling and coalescing binary black holes are promising sources of gravitational radiation. The orbital motion and gravitational-wave emission of such system can be modeled using a variety of approximation schemes and numerical methods in general relativity: The post-Newtonian (PN) formalism, black hole perturbation theory (BHP), numerical relativity (NR) simulations and the effective one-body (EOB) model. We review recent work at the multiple interfaces of these analytical and numerical techniques, emphasizing the use of coordinate-invariant relationships to perform meaningful comparison

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Vossen, Josephina A., Manon Buijs, Jean-Francois H. Geschwind, et al. "Diffusion-Weighted and Gd-EOB-DTPA-Contrast-Enhanced Magnetic Resonance Imaging for Characterization of Tumor Necrosis in an Animal Model." Journal of Computer Assisted Tomography 33, no. 4 (2009): 626–30. http://dx.doi.org/10.1097/rct.0b013e3181953df3.

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Forsgren, Mikael Fredrik, Olof Dahlqvist Leinhard, Nils Dahlström, Gunnar Cedersund, and Peter Lundberg. "Physiologically Realistic and Validated Mathematical Liver Model Revels Hepatobiliary Transfer Rates for Gd-EOB-DTPA Using Human DCE-MRI Data." PLoS ONE 9, no. 4 (2014): e95700. http://dx.doi.org/10.1371/journal.pone.0095700.

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Chen, Shuling, Shiting Feng, Jingwei Wei, et al. "Pretreatment prediction of immunoscore in hepatocellular cancer: a radiomics-based clinical model based on Gd-EOB-DTPA-enhanced MRI imaging." European Radiology 29, no. 8 (2019): 4177–87. http://dx.doi.org/10.1007/s00330-018-5986-x.

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Zheng, Rencheng, Chunzi Shi, Chengyan Wang, et al. "Imaging-Based Staging of Hepatic Fibrosis in Patients with Hepatitis B: A Dynamic Radiomics Model Based on Gd-EOB-DTPA-Enhanced MRI." Biomolecules 11, no. 2 (2021): 307. http://dx.doi.org/10.3390/biom11020307.

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Accurate grading of liver fibrosis can effectively assess the severity of liver disease and help doctors make an appropriate diagnosis. This study aimed to perform the automatic staging of hepatic fibrosis on patients with hepatitis B, who underwent gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging with dynamic radiomics analysis. The proposed dynamic radiomics model combined imaging features from multi-phase dynamic contrast-enhanced (DCE) images and time-domain information. Imaging features were extracted from the deep learning-base

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Granata, Vincenza, Roberta Fusco, Federica De Muzio, et al. "EOB-MR Based Radiomics Analysis to Assess Clinical Outcomes following Liver Resection in Colorectal Liver Metastases." Cancers 14, no. 5 (2022): 1239. http://dx.doi.org/10.3390/cancers14051239.

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The aim of this study was to assess the efficacy of radiomics features obtained by EOB-MRI phase in order to predict clinical outcomes following liver resection in Colorectal Liver Metastases Patients, and evaluate recurrence, mutational status, pathological characteristic (mucinous) and surgical resection margin. This retrospective analysis was approved by the local Ethical Committee board of National Cancer of Naples, IRCCS “Fondazione Pascale”. Radiological databases were interrogated from January 2018 to May 2021 in order to select patients with liver metastases with pathological proof and

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Petrash, E. A., M. A. Shorikov, E. V. Mikhaylova, and A. L. Nikulina. "Differential Diagnosis of Benign and Malignant Level Tumors in Children by Quantitative MRI with Intracellular Contrast Agent." Journal of oncology: diagnostic radiology and radiotherapy 4, no. 3 (2021): 56–63. http://dx.doi.org/10.37174/2587-7593-2021-4-3-56-63.

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Purpose: Тo determine the possibilities of quantitative assessment of mpMRI with EOB-DTPA in the differential diagnosis of benign and malignant tumors in children.Material and methods: 30 patients (male — 17, female — 13) with 83 tumors underwent MRI. Age ranged from 5 months to 20 years. All children underwent MRI on 3T or 1.5T MR-scanners using body coil. Fat saturated T1WI were performed before and after hepatotropic MR-contrast agent (gadoxetic acid) injection in arterial, portal, venous and delayed phases (1, 5, 20, 40 min). Tumors were divided into 2 groups: benign (52) and malignant (31

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Korkusuz, Huedayi, Lea L. Knau, Wolfgang Kromen, et al. "Different signal intensity at Gd-EOB-DTPA compared with Gd-DTPA-enhanced MRI in hepatocellular carcinoma transgenic mouse model in delayed phase hepatobiliary imaging." Journal of Magnetic Resonance Imaging 35, no. 6 (2012): 1397–402. http://dx.doi.org/10.1002/jmri.23584.

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Zhang, Shuai, Guizhi Xu, Chongfeng Duan, et al. "Radiomics Analysis of MR Imaging with Gd-EOB-DTPA for Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma: Investigation and Comparison of Different Hepatobiliary Phase Delay Times." BioMed Research International 2021 (January 7, 2021): 1–8. http://dx.doi.org/10.1155/2021/6685723.

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Purpose. To investigate whether the radiomics analysis of MR imaging in the hepatobiliary phase (HBP) can be used to predict microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). Method. A total of 130 patients with HCC, including 80 MVI-positive patients and 50 MVI-negative patients, who underwent MR imaging with Gd-EOB-DTPA were enrolled. Least absolute shrinkage and selection operator (LASSO) regression was applied to select radiomics parameters derived from MR images obtained in the HBP 5 min, 10 min, and 15 min images. The selected features at each phase were adopt

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Markov, A. A., E. G. Kostolomova, T. Kh Timokhina, et al. "Effect of <i>Bifidobacterium bifidum</i> supernatant on the morphological and functional characteristics of human fibroblasts in real time during an <i>in vitro</i> experiment." Medical Immunology (Russia) 25, no. 3 (2023): 581–86. http://dx.doi.org/10.15789/1563-0625-eob-2720.

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Currently, there is an active search for exogenous stimulators of repair and regeneration processes. In the recent decades, some data on the immunotropic activity of bifidobacteria have been accumulated. The key role in healing of wound defects belongs to fibroblasts due to the secretion of the extracellular matrix components, metabolites, signal factors for the surrounding cells, and tissue metabolism regulation. The paper presents the results of the study of the effect of Bifidobacterium bifidum supernatant (10 ml/mL) on the morphological and functional properties of human fibroblasts in rea

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Islam, Md Kamrul, Ah-Rum Baek, Byeong-Woo Yang, et al. "Manganese (II) Complex of 1,4,7-Triazacyclononane-1,4,7-Triacetic Acid (NOTA) as a Hepatobiliary MRI Contrast Agent." Pharmaceuticals 16, no. 4 (2023): 602. http://dx.doi.org/10.3390/ph16040602.

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Magnetic resonance imaging (MRI) is increasingly used to diagnose focal and diffuse liver disorders. Despite their enhanced efficacy, liver-targeted gadolinium-based contrast agents (GBCAs) raise safety concerns owing to the release of toxic Gd3+ ions. A π-conjugated macrocyclic chelate, Mn-NOTA-NP, was designed and synthesized as a non-gadolinium alternative for liver-specific MRI. Mn-NOTA-NP exhibits an r1 relaxivity of 3.57 mM−1 s−1 in water and 9.01 mM−1 s−1 in saline containing human serum albumin at 3 T, which is significantly greater than the clinically utilized Mn2+-based hepatobiliary

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MORIYAMA, Yuki, Shigeyoshi SAITO, Shuichiro KOBAYASHI, et al. "Evaluation of Concanavalin A-induced Acute Liver Injury in Rats using an Empirical Mathematical Model and Dynamic Contrast-enhanced MR Imaging with Gd-EOB-DTPA." Magnetic Resonance in Medical Sciences 11, no. 1 (2012): 53–60. http://dx.doi.org/10.2463/mrms.11.53.

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Saito, Shigeyoshi, Yuki Moriyama, Shuichiro Kobayashi, et al. "Assessment of liver function in thioacetamide-induced rat acute liver injury using an empirical mathematical model and dynamic contrast-enhanced MRI with Gd-EOB-DTPA." Journal of Magnetic Resonance Imaging 36, no. 6 (2012): 1483–89. http://dx.doi.org/10.1002/jmri.23726.

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Ma, Chunmei, Ailian Liu, Yuanyuan Wang, et al. "The hepatocyte phase of Gd-EOB-DTPA-enhanced MRI in the evaluation of hepatic fibrosis and early liver cirrhosis in a rat model: An experimental study." Life Sciences 108, no. 2 (2014): 104–8. http://dx.doi.org/10.1016/j.lfs.2014.05.016.

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Strotzer, Quirin David, Hinrich Winther, Kirsten Utpatel, et al. "Application of A U-Net for Map-Like Segmentation and Classification of Discontinuous Fibrosis Distribution in Gd-EOB-DTPA-Enhanced Liver MRI." Diagnostics 12, no. 8 (2022): 1938. http://dx.doi.org/10.3390/diagnostics12081938.

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We aimed to evaluate whether U-shaped convolutional neuronal networks can be used to segment liver parenchyma and indicate the degree of liver fibrosis/cirrhosis at the voxel level using contrast-enhanced magnetic resonance imaging. This retrospective study included 112 examinations with histologically determined liver fibrosis/cirrhosis grade (Ishak score) as the ground truth. The T1-weighted volume-interpolated breath-hold examination sequences of native, arterial, late arterial, portal venous, and hepatobiliary phases were semi-automatically segmented and co-registered. The segmentations we

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Zhou, Zhi-Peng, Li-Ling Long, Li-Juan Huang, Teng-Fei Yang, and Zhong-Kui Huang. "Gd-EOB-DTPA-enhanced MRI T1 mapping for assessment of liver function in rabbit fibrosis model: comparison of hepatobiliary phase images obtained at 10 and 20 min." La radiologia medica 122, no. 4 (2017): 239–47. http://dx.doi.org/10.1007/s11547-016-0719-1.

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Dong, Haoyu, Shijie Liu, Shi Han, Zhouyu Fu, and Dongmei Zhang. "TableSense: Spreadsheet Table Detection with Convolutional Neural Networks." Proceedings of the AAAI Conference on Artificial Intelligence 33 (July 17, 2019): 69–76. http://dx.doi.org/10.1609/aaai.v33i01.330169.

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Spreadsheet table detection is the task of detecting all tables on a given sheet and locating their respective ranges. Automatic table detection is a key enabling technique and an initial step in spreadsheet data intelligence. However, the detection task is challenged by the diversity of table structures and table layouts on the spreadsheet. Considering the analogy between a cell matrix as spreadsheet and a pixel matrix as image, and encouraged by the successful application of Convolutional Neural Networks (CNN) in computer vision, we have developed TableSense, a novel end-to-end framework for

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Hutchings, Kasen Reed, Patrick Beck, Kevin J. Pridham, et al. "Overcoming temozolomide resistance in glioblastoma through selective inhibition of phosphoinositide 3-kinase catalytic subunit." Journal of Clinical Oncology 41, no. 16_suppl (2023): e14045-e14045. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e14045.

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e14045 Background: Glioblastoma is one of medicine's most difficult-to-treat cancers due to its inevitable resistance to chemotherapies, such as temozolomide (TMZ). Tumor resistance to TMZ often comes from overactivation of phosphoinositide 3-kinase (PI3K), making this enzyme an ideal anti-cancer drug target; however, in practice, non-selective targeting of PI3K has resulted in undesirable clinical outcomes. Therefore, it is necessary to explore each subunit of PI3K to determine their effect on chemoresistance in order to develop therapeutics to overcome said resistance. PI3K has four homologo

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Yu, Nong, Shuangming Lin, Xiaojie Wang, et al. "Endoscopic obstruction predominantly occurs in right-side colon cancer and endoscopic obstruction with tumor size ≤ 5 cm seems poor prognosis in colorectal cancer." Frontiers in Oncology 14 (June 14, 2024). http://dx.doi.org/10.3389/fonc.2024.1415345.

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BackgroundEndoscopic obstruction (eOB) is associated with a poor prognosis in colorectal cancer (CRC). Our study aimed to investigate the association between tumor location and eOB, as well as the prognostic differences among non-endoscopic obstruction (N-eOB), eOB with tumor size ≤ 5 cm, and eOB with tumor size &gt; 5 cm in non-elderly patients.MethodsWe retrospectively reviewed the clinicopathological variables of 230 patients with CRC who underwent curative surgery. The multivariable logistic regression model was used to identify risk factors for eOB. The association between eOB with tu

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Caviggioli, Federico, and Boris Forthmann. "Reach for the stars: disentangling quantity and quality of inventors’ productivity in a multifaceted latent variable model." Scientometrics, March 23, 2022. http://dx.doi.org/10.1007/s11192-022-04328-3.

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AbstractStar inventors generate superior innovation outcomes. Their capacity to invent high-quality patents might be decisive beyond mere productivity. However, the relationship between quantitative and qualitative dimensions has not been exhaustively investigated. The equal odds baseline (EOB) framework can explicitly model this relationship. This work combines a theoretical model for creative production with recent calls in the patentometrics literature for multifaceted measurement of the ability to create high-quality patents. The EOB is extended and analyzed through structural equation mod

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Wu, Hongzhen, Yingying Liang, Zihua Wang, et al. "Optimizing CT and MRI criteria for differentiating intrahepatic mass-forming cholangiocarcinoma and hepatocellular carcinoma." Acta Radiologica, July 27, 2022, 028418512211132. http://dx.doi.org/10.1177/02841851221113265.

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Background Accurate diagnosis of intrahepatic mass-forming cholangiocarcinoma (IMCC) is crucial with regard to the choice of patient management and treatment options. Purpose To evaluate the feasibility and diagnostic performance of the LI-RADS M (LR-M) targetoid criteria on computed tomography (CT) and gadoxetic acid–enhanced magnetic resonance imaging (EOB-MRI) in differentiating IMCC from hepatocellular carcinoma (HCC). Material and Methods A total of 118 patients with IMCC and HCC were included who underwent CT and EOB-MRI examinations. Multivariate analysis was used to determine the stron

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