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1
G protein-coupled receptor genetics : Research and methods in the post-genomic era. New York : Humana Press, 2014.
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Kihara, Daisuke, dir. Protein Function Prediction for Omics Era. Dordrecht : Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-0881-5.
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Brazauskas, Gintaras, Gražina Statkevičiūtė et Kristina Jonavičienė, dir. Breeding Grasses and Protein Crops in the Era of Genomics. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89578-9.
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N, Kholodenko Boris, et Westerhoff Hans V, dir. Metabolic engineering in the post genomic era. Wymondham, Norfolk, England : Horizon Bioscience, 2004.
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J, Blencowe Benjamin, et Graveley Brenton R, dir. Alternative splicing in the postgenomic era. New York : Springer Science+Business Media, 2007.
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Commonwealth Scientific and Industrial Research Organization, dir. Nutrient requirements of domesticated ruminants. Collingwood : CSIRO Publishing, 2007.
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Garlin, Sender. Three American radicals : John Swinton, crusading editor : Charles P. Steinmetz, scientist and socialist : William Dean Howells and the Haymarket Era. Boulder : Westview Press, 1991.
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Zdeněk, Deyl, dir. Advanced chromatographic and electromigration methods in biosciences. Amsterdam : Elsevier, 1998.
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Handbook of detection of enzymes on electrophoretic gels. 2e éd. Boca Raton : CRC Press, 2003.
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Manchenko, Gennady P. Handbook of detection of enzymes on electrophoretic gels. 2e éd. Boca Raton, FL : CRC Press, 2002.
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Manchenko, Gennady P. Handbook of detection of enzymes on electrophoretic gels. Boca Raton, Fla : CRC Press, 1994.
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Nakamura, Tomohiro, et Stuart A. Lipton. Neurodegenerative Diseases as Protein Misfolding Disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190233563.003.0002.
Texte intégralRésumé :
Neurodegenerative diseases (NDDs) often represent disorders of protein folding. Rather than large aggregates, recent evidence suggests that soluble oligomers of misfolded proteins are the most neurotoxic species. Emerging evidence points to small, soluble oligomers of misfolded proteins as the cause of synaptic dysfunction and loss, the major pathological correlate to disease progression in many NDDs including Alzheimer’s disease. The protein quality control machinery of the cell, which includes molecular chaperones as found in the endoplasmic reticulum (ER), the ubiquitin-proteasome system (UPS), and various forms of autophagy, can counterbalance the accumulation of misfolded proteins to some extent. Their ability to eliminate the neurotoxic effects of misfolded proteins, however, declines with age. A plausible explanation for the age-dependent deterioration of the quality control machinery involves compromise of these systems by excessive generation of reactive oxygen species (ROS), such as superoxide anion (O2-), and reactive nitrogen species (RNS), such as nitric oxide (NO). The resulting redox stress contributes to the accumulation of misfolded proteins. Here, we focus on aberrantly increased generation of NO-related species since this process appears to accelerate the manifestation of key neuropathological features, including protein misfolding. We review the chemical mechanisms of posttranslational modification by RNS such as protein S-nitrosylation of critical cysteine thiol groups and nitration of tyrosine residues, showing how they contribute to the pathogenesis of NDDs.
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Kumar, Dhiraj, et Rajesh R. Kundapur. Biomedical Applications of Natural Proteins : An Emerging Era in Biomedical Sciences. Springer, 2015.
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Kumar, Dhiraj, et Rajesh R. Kundapur. Biomedical Applications of Natural Proteins : An Emerging Era in Biomedical Sciences. Ingramcontent, 2015.
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Stevens, Craig W. G Protein-Coupled Receptor Genetics : Research and Methods in the Post-Genomic Era. Humana Press, 2016.
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Kihara, Daisuke. Protein Function Prediction for Omics Era. Springer, 2011.
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Kihara, Daisuke. Protein Function Prediction for Omics Era. Springer London, Limited, 2011.
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Kihara, Daisuke. Protein Function Prediction for Omics Era. Springer Netherlands, 2014.
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20
Bioinformatics in the Post-Genomic Era : The Role of Biophysics. Nova Science Publishers, 2007.
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Breeding Grasses and Protein Crops in the Era of Genomics. Springer, 2019.
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22
Brazauskas, Gintaras, Gražina Statkevičiūtė et Kristina Jonavičienė. Breeding Grasses and Protein Crops in the Era of Genomics. Springer, 2018.
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23
Diggs, Barbara. Boycotts, Marches, and Strikes : Protests of the Civil Rights Era. Nomad Press, 2020.
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Boycotts, Marches, and Strikes : Protests of the Civil Rights Era. Nomad Press, 2020.
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25
Moura, Rosa Maria Braga Lopes de. Tratamentos da Doença de Alzheimer : Perspectivas e Bioética. Sous la direction de Marcia Alessandra Arantes Marques. Bookerfield Editora, 2021. http://dx.doi.org/10.53268/bkf21090500.
Texte intégralRésumé :
A Doença de Alzheimer (DA) é um distúrbio neurodegenerativo progressivo associado com um acúmulo de placas da proteína beta amiloide (Aβ) senis extracelulares e o excesso de emaranhados neurofibrilares da proteína Tau dentro das células. Foi descrita inicialmente pelo médico alemão Alois Alzheimer, em 1906 caracterizando como uma patologia neurológica, de etiologia desconhecida e de aparecimento insidioso. O sistema nervoso central é particularmente vulnerável aos danos causados pelos radicais livres por apresentar alto consumo de oxigênio e possuir grande quantidade de ácidos graxos poli-insaturados e nível diminuído de enzimas antioxidantes afetando a memória e aprendizado. De uma maneira geral, o estresse oxidativo no cérebro de pacientes com Doença de Alzheimer está manifestado pelo aumento da oxidação proteica, peroxidação lipídica, oxidação do DNA e RNA e formação de espécies reativas de oxigênio. O desenvolvimento de opções terapêuticas mais eficazes e seguras consiste em um dos objetivos mais avidamente perseguidos no cenário científico internacional. Drogas capazes de modificar a evolução natural da doença, ao lado da antecipação do diagnóstico, representarão o futuro do tratamento da DA e outras demências. Nesse contexto, a compreensão dos mecanismos que levam à morte neuronal na DA será a base para o desenvolvimento de novas drogas. Tendo em vista essas considerações, a Bioética oferece ferramentas para resolver os dilemas que apresentam os avanços científicos dentro dos limites éticos impostos pelo respeito à pessoa humana ao discutir se as perspectivas futuras de tratamentos respeitam os princípios de dignidade humana e de justiça. Foi levando em consideração tais aspectos, que o eixo central deste livro é a Doença de Alzheimer e sua relação com a bioética.
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Moura, Rosa Maria Braga Lopes de. Tratamentos da Doença de Alzheimer : Perspectivas e Bioética. Sous la direction de Marcia Alessandra Arantes Marques. Bookerfield Editora, 2021. http://dx.doi.org/10.53268/bkf21090500.
Texte intégralRésumé :
A Doença de Alzheimer (DA) é um distúrbio neurodegenerativo progressivo associado com um acúmulo de placas da proteína beta amiloide (Aβ) senis extracelulares e o excesso de emaranhados neurofibrilares da proteína Tau dentro das células. Foi descrita inicialmente pelo médico alemão Alois Alzheimer, em 1906 caracterizando como uma patologia neurológica, de etiologia desconhecida e de aparecimento insidioso. O sistema nervoso central é particularmente vulnerável aos danos causados pelos radicais livres por apresentar alto consumo de oxigênio e possuir grande quantidade de ácidos graxos poli-insaturados e nível diminuído de enzimas antioxidantes afetando a memória e aprendizado. De uma maneira geral, o estresse oxidativo no cérebro de pacientes com Doença de Alzheimer está manifestado pelo aumento da oxidação proteica, peroxidação lipídica, oxidação do DNA e RNA e formação de espécies reativas de oxigênio. O desenvolvimento de opções terapêuticas mais eficazes e seguras consiste em um dos objetivos mais avidamente perseguidos no cenário científico internacional. Drogas capazes de modificar a evolução natural da doença, ao lado da antecipação do diagnóstico, representarão o futuro do tratamento da DA e outras demências. Nesse contexto, a compreensão dos mecanismos que levam à morte neuronal na DA será a base para o desenvolvimento de novas drogas. Tendo em vista essas considerações, a Bioética oferece ferramentas para resolver os dilemas que apresentam os avanços científicos dentro dos limites éticos impostos pelo respeito à pessoa humana ao discutir se as perspectivas futuras de tratamentos respeitam os princípios de dignidade humana e de justiça. Foi levando em consideração tais aspectos, que o eixo central deste livro é a Doença de Alzheimer e sua relação com a bioética.
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Lennon, Rachel, et Neil Turner. The molecular basis of glomerular basement membrane disorders. Sous la direction de Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0320_update_001.
Texte intégralRésumé :
The glomerular basement membrane (GBM) is a condensed network of extracellular matrix molecules which provides a scaffold and niche to support the function of the overlying glomerular cells. Within the glomerulus, the GBM separates the fenestrated endothelial cells, which line capillary walls from the epithelial cells or podocytes, which cover the outer aspect of the capillaries. In common with basement membranes throughout the body, the GBM contains core components including collagen IV, laminins, nidogens, and heparan sulphate proteoglycans. However, specific isoforms of these proteins are required to maintain the integrity of the glomerular filtration barrier.Across the spectrum of glomerular disease there is alteration in glomerular extracellular matrix (ECM) and a number of histological patterns are recognized. The GBM can be thickened, expanded, split, and irregular; the mesangial matrix may be expanded and glomerulosclerosis represents a widespread accumulation of ECM proteins associated with loss of glomerular function. Whilst histological patterns may follow a sequence or provide diagnostic clues, there remains limited understanding about the mechanisms of ECM regulation and how this tight control is lost in glomerular disease. Monogenic disorders of the GBM including Alport and Pierson syndromes have highlighted the importance of both collagen IV and laminin isoforms and these observations provide important insights into mechanisms of glomerular disease.
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Atkins, Marc S. The Meaning of Mental Health (and Other Lessons Learned). Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780195320268.003.0007.
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Massaharu Hassunuma, Renato, Patrícia Carvalho Garcia et Sandra Heloísa Nunes Messias, dir. Proteínas envolvidas em Patologias – volume 4. Canal 6 Editora, 2022. http://dx.doi.org/10.52050/9788579175824.
Texte intégralRésumé :
Este livro representa o quarto volume da Coleção: Proteínas envolvidas em Patologias, publicada pela Canal 6 Editora. É resultado do Workshop de Princípios de Bioinformática, ministrado pelo Prof. Dr. Renato Massaharu Hassunuma, e promovido pelo Curso de Biomedicina da UNIP – Bauru, G3B3 – Grupo de Estudos em Bioinformática Estrutural e GP15 – Grupo de Estudos em Informática em Saúde. Neste volume, o leitor pode encontrar mais informações sobre as estruturas bioquímicas de algumas proteínas e suas relações com a etiopatogenia de determinadas doenças.
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Olsson, Per-Anders. Mir : A Novel Erm-Like Protein in the Nervous System (Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1052). Uppsala Universitet, 2001.
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Horsley, Alex. Genetics and pathophysiology. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198702948.003.0001.
Texte intégralRésumé :
This chapter describes the genetics and inheritance of CF. Different mutations have different effects on the CFTR protein, some leading to no CFTR being expressed at all and others to a poorly functioning variant. In the new era of mutation-specific therapies, the specific mutation expressed in a patient has important implications for their treatment.
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Laureno, Robert. Selected Concepts. Sous la direction de Robert Laureno. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190607166.003.0016.
Texte intégralRésumé :
This chapter on “Selected Concepts” examines the evolution of neurological concepts during the modern era. Examples presented include the concepts of transient ischemic attack, disconnection syndrome, thoracic outlet syndrome, and Wilbrand’s knee. Over the past half century, neurology has witnessed great technological advances. Newer scientific methods, such as MRI scanning, have led to new knowledge that has necessitated changes in neurologic concepts. During recent decades, new concepts have emerged. Infectious proteins, antibody-mediated brain disease, channelopathies, and the glymphatic system are relatively new ideas, and we cannot foresee how our understanding of these concepts will be advanced or modified in the coming decades.
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Lee, Francis L. F., et Joseph M. Chan. Media and Protest Logics in the Digital Era. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190856779.001.0001.
Texte intégralRésumé :
Digital and social media are increasingly integrated into dynamics of protest movements. They strengthen the mobilization power of movements, extend movement networks, facilitate new modes of protest participation, and lead to the emergence of new protest formations. Meanwhile, conventional media remain an important arena where the contest for public support between protesters and their targets play out. This book examines the role of the media—understood as an integrated system composed of both conventional media institutions and digital media platforms—in the formation and dynamics of the Umbrella Movement in Hong Kong in 2014. It grounds the analysis into the broad background of the rise of protest politics in Hong Kong since the early 2000s. More important, this book connects the case of the Umbrella Movement to recent theorizations of new social movement formations. It treats the Umbrella Movement as a case where connective action intervenes into a collective action campaign, leading to an extended occupation mixing old and new protest logics. The analysis shows how the media had not only empowered the protest movements in certain ways, but also introduced forces not conducive to the sustainability and efficacy of the movement. Conventional and digital media could also be used by the state to undermine protests. Through a combination of protester surveys, population surveys, analyses of news contents, and social media activities, this book reconstructs a rich and nuanced account of the Umbrella Movement, which helps shed light on numerous issues about the media-movement nexus in the digital era.
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Passavant, Paul A. Policing Protest. Duke University Press, 2021. http://dx.doi.org/10.1215/9781478013013.
Texte intégralRésumé :
In Policing Protest Paul A. Passavant explores how the policing of protest in the United States has become increasingly hostile since the late 1990s, moving away from strategies that protect protesters toward militaristic practices designed to suppress protests. He identifies reactions to three interrelated crises that converged to institutionalize this new mode of policing: the political mobilization of marginalized social groups in the Civil Rights era that led to a perceived crisis of democracy, the urban fiscal crisis of the 1970s, and a crime crisis that was associated with protests and civil disobedience of the 1960s. As Passavant demonstrates, these reactions are all haunted by the figure of black insurrection, which continues to shape policing of protest and surveillance, notably in response to the Black Lives Matter movement. Ultimately, Passavant argues, this trend of violent policing strategies against protesters is evidence of the emergence of a post-democratic state in the United States.
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Norton, Barley. Music and Censorship in Vietnam since 1954. Sous la direction de Patricia Hall. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199733163.013.29.
Texte intégralRésumé :
This chapter traces the history of music censorship in Vietnam since 1954 with reference to a broad range of music genres. It discusses music censorship from 1954 to 1975, when Vietnam was divided into North and South. The tight ideological control established by the Vietnamese Communist Party in the North is compared with music movements linked to antiwar protests in the South. The chapter then examines the period of severe censorship following the end of the Vietnamese-American war in 1975 and considers how the cultural climate changed in the reform era after 1986. It highlights the limits of cultural freedom in the reform era and discusses how music censorship has become intertwined with concerns about the effects of globalization on morality and national identity. Finally, the chapter addresses the impact of technology since the late 1990s, paying particular attention to Vietnamese rap and the potential for musicians to use the Internet to bypass conventional systems of state censorship.
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Aparecido da, Fábio, Ana Kelly Kapp Poli Schneider et Renato Massaharu Hassunuma. CARTAG : livro-jogo sobre o código genético & ; alterações cromossômicas estruturais. Canal 6 Editora, 2022. http://dx.doi.org/10.52050/9788579175794.
Texte intégralRésumé :
O termo CÓDIGO GENÉTICO refere-se à relação que existe entre a sequência de bases nitrogenadas do ácido desoxirribonucleico (DNA) e a sequência correspondente de aminoácidos em uma proteína. Este LIVRO-JOGO tem como proposta ensinar para alunos de diferentes níveis de ensino por meio de cartas, como entender o código genético e algumas das principais alterações cromossômicas estruturais. O CARTAG é um jogo formado por uma ficha de consulta do código genético e três baralhos: um de códons, outro de aminoácidos e um último de alterações cromossômicas estruturais.
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Dantas Filho, Jerônimo Vieira, Paulo Henrique Gilio Gasparotto, Jucilene Cavali et Sandro de Vargas Schons. Tecnologias agropecuárias e ambientais : revisões e aplicações. Brazilian Journals Editora, 2022. http://dx.doi.org/10.35587/brj.ed.0001698.
Texte intégralRésumé :
Trata-se de uma obra transdisciplinar, com enfoque na aplicação de agrotecnologias e tecnologias da informação às Ciências Agrárias, mais especificamente abordando o emprego e difusão de tecnologias no Agronegócio, com a finalidade de proporcionar Sustentabilidade nos sistemas de produção animal. A publicação contempla várias áreas de conhecimento, Engenharia de Pesca e Aquicultura, Sistemas de Informação, Medicina Veterinária, Zootecnia, etc. E, está organizada em dez capítulos, 1. Tecnologias da informação aplicadas à Engenharia de Pesca e Aquicultura, 2. Carne mecanicamente separada de pescado, 3. Agrotóxicos e medicamentos veterinários encontrados em Piscicultura, 4. Resíduos de agrotóxicos e medicamentos veterinários encontrados no leite, 5. Resistência do carrapato Rhipicephalus (Boophilus) Microplus (CANESTRINI, 1888) e impactos na pecuária, 6. Narasina e monensina: aditivos em suplementos proteico-energético-mineral para bovinos Nelores criados a pasto, 7. Características sanitárias e teor de umidade de charque industrializado comercializado em Ji-Paraná, Rondônia, 8. Teste de CMT (California Mastites Test) em uma propriedade leiteira no município de Urupá, Rondônia, 9. Acidez no leite em um laticínio com Inspeção Federal na Região Central do estado de Rondônia, 10. Exame parasitológico de fezes em bovinos no Laboratório de Parasitologia Veterinária, Centro Universitário São Lucas, Ji-Paraná, Rondônia.
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Sturken, Marita. Terrorism in American Memory. NYU Press, 2022. http://dx.doi.org/10.18574/nyu/9781479811670.001.0001.
Texte intégralRésumé :
This book examines the role of cultural memory in the post-9/11 era of American culture, an era that begins with 9/11 memorialization and ends with battles over the memory of racial injustice. The book argues that 9/11 was a shaping force in the two decades that followed and that the post-9/11 era came to a close in the disruption of the COVID-19 pandemic and protests of 2020. The post-9/11 era thus begins with the numerous nationalistic memorial projects of 9/11 and ends with the radical intervention of the Legacy Museum and the National Memorial for Peace and Justice in Montgomery, Alabama, a project that dramatically rewrites the national script of American history. The book looks in depth at the proliferation of 9/11 memorials, with thousands of memorials built from the bent steel of the twin towers throughout the country, and situates the 9/11 museum in New York and the architectural rebuilding of lower Manhattan as an intermix of memorialization, securitization, commercialization, and starchitecture. It analyzes the erasure of the post-9/11 wars in Iraq and Afghanistan and the memory projects that have aimed to render their human and economic costs visible. Finally, it examines the Legacy Museum and the National Memorial for Peace and Justice in Montgomery as a project of memory activism that aims to memorialize the legacies of slavery and lynching as a means to intervene into the consequences of mass incarceration in the present.
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Nickerson, Michelle. Women, Gender, and Conservatism in Twentieth-Century America. Sous la direction de Ellen Hartigan-O'Connor et Lisa G. Materson. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190222628.013.12.
Texte intégralRésumé :
Women have participated in conservative movement politics throughout the twentieth century. From opposition mounted against Progressive-era health and welfare legislation to protests against Franklin Roosevelt’s New Deal to culture war battles with feminists, conservative women have never completely ceded the right side of the political spectrum to men. Essentialist notions of what is “natural” to women, their bodies, and their connection to children and the family, have been the basis of conservative female politics throughout the twentieth century and beyond. Women on the right have drawn from a corpus of beliefs, ideals, and assumptions passed down from generations of political forbears about the natural conservatism of women—an intuitive drive to protect the young and bring calm to the space around them. This chapter examines the impact of that ideology, in its various iterations, over the course of the twentieth century.
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Parker, Traci. Department Stores and the Black Freedom Movement. University of North Carolina Press, 2019. http://dx.doi.org/10.5149/northcarolina/9781469648675.001.0001.
Texte intégralRésumé :
In this book, Traci Parker examines the movement to racially integrate white-collar work and consumption in American department stores, and broadens our understanding of historical transformations in African American class and labor formation. Built on the goals, organization, and momentum of earlier struggles for justice, the department store movement channeled the power of store workers and consumers to promote black freedom in the mid-twentieth century. Sponsoring lunch counter sit-ins and protests in the 1950s and 1960s, and challenging discrimination in the courts in the 1970s, this movement ended in the early 1980s with the conclusion of the Sears, Roebuck, and Co. affirmative action cases and the transformation and consolidation of American department stores. In documenting the experiences of African American workers and consumers during this era, Parker highlights the department store as a key site for the inception of a modern black middle class, and demonstrates the ways that both work and consumption were battlegrounds for civil rights.
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Wu, Helena Y. W. The Hangover after the Handover. Liverpool University Press, 2020. http://dx.doi.org/10.3828/liverpool/9781789621952.001.0001.
Texte intégralRésumé :
As a former British colony (1842-1997) and now a Special Administrative Region (from 1997 onwards) practicing the “One Country Two Systems” policy with the People’s Republic of China, Hong Kong has witnessed at all times how relations are formed, dissolved and refashioned amidst changing powers, identities and narratives. With an eye to real-life events and cultural representations, the book presents an interdisciplinary study of “local relations” through the lens of the things and places that stand or that have once stood for Hong Kong’s “local”. The book argues that the signification of the local and the constellation of local relations embody the continuous acts of deterritorialization and reterritorialization beyond the political arena and through the cultural and social relations formed between cultural icons and urban dwellers. In its post-handover, post-hangover years where Hong Kong’s local multiples by appearance and connotation as in the 2014 Umbrella Movement and the 2019 Anti-Extradition Bill Protests, the book proposes lessons to learn from the city in face of the discourses of nationalism, globalization and localism. As more are to unfold, the book opens up manifold postcolonial perspectives by the agency of both human and nonhuman to confront and interrogate the contemporary experiences—unprecedented since the Cold War era—shared by Hong Kong and the world where established beliefs and systems are continuously challenged in the postmillennial era. After all, what does it mean, or take, to live in post-1997 Hong Kong when the local, global and national are constantly given new meanings?
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Crepeau, Richard C. NFL Football. University of Illinois Press, 2020. http://dx.doi.org/10.5622/illinois/9780252043581.001.0001.
Texte intégralRésumé :
A multibillion-dollar entertainment empire, the National Football League is a coast-to-coast obsession that borders on religion and dominates our sports-mad culture. But today's NFL also provides a stage for playing out important issues roiling American society. This updated and expanded edition of NFL Football observes the league's centennial by following the NFL into the twenty-first century, where off-the-field concerns compete with touchdowns and goal line stands for headlines. Richard C. Crepeau delves into the history of the league and breaks down the new era with an in-depth look at the controversies and dramas swirling around pro football today: Tensions between players and Commissioner Roger Goodell over collusion, drug policies, and revenue, including analysis of the 2020 collective bargaining agreement The firestorm surrounding Colin Kaepernick and protests of police violence and inequality Andrew Luck and others choosing early retirement over the threat to their long-term health Paul Tagliabue's role in covering up information on concussions The Super Bowl's evolution into a national holiday Authoritative and up to the minute, NFL Football continues the epic American success story.
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Crowley, Stephen. Putin's Labor Dilemma. Cornell University Press, 2021. http://dx.doi.org/10.7591/cornell/9781501756276.001.0001.
Texte intégralRésumé :
This book investigates how the fear of labor protest has inhibited substantial economic transformation in Russia. Vladimir Putin boasts he has the backing of workers in the country's industrial heartland, but as economic growth slows in Russia, reviving the economy will require restructuring the country's industrial landscape. At the same time, doing so threatens to generate protest and instability from a key regime constituency. However, continuing to prop up Russia's Soviet-era workplaces, the book suggests, could lead to declining wages and economic stagnation, threatening protest and instability. The book explores the dynamics of a Russian labor market that generally avoids mass unemployment, the potentially explosive role of Russia's monotowns, conflicts generated by massive downsizing in “Russia's Detroit” (Tol'yatti), and the rapid politicization of the truck drivers movement. Labor protests currently show little sign of threatening Putin's hold on power, but the manner in which they are being conducted point to substantial chronic problems that will be difficult to resolve. The book demonstrates that the Russian economy must either find new sources of economic growth or face stagnation. Either scenario — market reforms or economic stagnation — raises the possibility, even probability, of destabilizing social unrest.
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Masters, Samantha, Imkhitha Nzungu et Grant Parker. (u)Mzantsi Classics : Dialogues in Decolonisation from Southern Africa. African Minds, 2022. http://dx.doi.org/10.47622/9781928502302.
Texte intégralRésumé :
Though Graeco-Roman antiquity (‘classics’) has often been considered the handmaid of colonialism, its various forms have nonetheless endured through many of the continent’s decolonising transitions. Southern Africa is no exception. This book canvasses the variety of forms classics has taken in Zimbabwe, Mozambique and especially South Africa, and even the dynamics of transformation itself. How does (u)Mzantsi classics (of southern Africa) look in an era of profound change, whether violent or otherwise? What are its future prospects? Contributors focus on pedagogies, historical consciousness, the creative arts and popular culture. The volume, in its overall shape, responds to the idea of dialogue – in both the Greek form associated with Plato’s rendition of Socrates’ wisdom and in the African concept of ubuntu. Here are dialogues between scholars, both emerging and established, as well as students – some of whom were directly impacted by the Fallist protests of the late 20-teens. Rather than offering an apologia for classics, these dialogues engage with pressing questions of relevance, identity, change, the canon, and the dynamics of decolonisation and potential recolonisation. The goal is to interrogate classics – the ways it has been taught, studied, perceived, transformed and even lived – from many points of view.
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Moseley, Mason W. Protest State. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190694005.001.0001.
Texte intégralRésumé :
In the midst of an unprecedented era of democratic governments and economic prosperity, why are a record number of Latin American citizens choosing to participate in protests? This book argues that increasingly engaged citizenries, forged by economic progress and technological advances throughout the region, combined with dysfunctional political institutions have fueled more contentious modes of participation in Latin America, as citizens’ demands for government responsiveness have overwhelmed many regimes’ institutional capacity to provide it. Where weak institutions and active citizenries collide, countries can morph into “protest states,” where contentious participation becomes so common as to render it a conventional characteristic of everyday political life. Drawing on cross-national surveys from Latin America and a case study of Argentina, which includes a rich dataset of protest events and dozens of interviews with political elites and citizen activists, Moseley tests this explanation against other leading theories in the contentious politics literature. Rather than emphasizing how worsening economic conditions and mounting grievances fuel protest, this book builds the case that it is actually the improvement of economic conditions amid low-quality political institutions that lies at the root of surging contention in the region. In presenting and systematically defending this novel approach, Protest State offers a comprehensive multilevel, mixed-methods study of one of the most intriguing puzzles in Latin American politics today.
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Metz, Michael V. Radicals in the Heartland. University of Illinois Press, 2019. http://dx.doi.org/10.5622/illinois/9780252042416.001.0001.
Texte intégralRésumé :
Entering the 1960s, the University of Illinois typified “Middle America,” with its midwestern campus, middle-class enrollment, and midcentury quiescence—the unlikeliest of settings for protest, rebellion, and riots in the streets. But all of that came to pass. Born of free-speech issues in the Red Scare era and nourished by anger with an unpopular war, protests grew into a general antiestablishment frustration, climaxing in a student strike and days-long violent disturbances that shut down one of the nation’s largest land-grant universities. How could this happen, here? The story is one of self-important legislators, well-intentioned administrators, a conservative citizenry, and “outside agitators,” but mostly of a minority of confident, determined, somewhat naïve students. Virtually all white, relatively privileged, raised in a postwar economic boom, believers in and embodiment of American exceptionalism, they would confront moral questions around race, justice, war, life, and death that became existential as the body count rose in Vietnam. This is the story of how those Illini students responded. No one could have predicted rebellion would happen here. But it did. These young people helped bring down one president, shamed a second, and helped lead the nation to end a wretched war. By their agency they changed history. And if such a movement could happen in such an unlikely place, who is to say that another, equally unlikely, might not happen again?
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Twarog, Emily E. LB. Politics of the Pantry. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190685591.001.0001.
Texte intégralRésumé :
This book examines the rise and fall of the American housewife as a political constituency group and explores the relationship between the domestic sphere and the formation of political identity. This book is a study of how women used institutions built on patriarchy and consumer capitalism to cultivate a political voice. Using a labor history lens, it places the home rather than the workplace at the center of the community, revealing new connections between labor, gender, and citizenship. Three periods of consumer upheaval anchor the narrative: the Depression-era meat boycott of 1935, the consumer coalitions of the New Deal and the rise of the Cold War, and the wave of consumer protests in the 1960s and 1970s. The book is framed around the lives of several key labor and consumer activists and their organizations in both urban and suburban areas—Detroit, Chicagoland, Long Island, and Los Angeles. The geographic diversity of these three periods allows for a national story about the influence of domestic politics between the New Deal and the election of Ronald Reagan and the emergence of the conservative right. Some of these women have appeared in other historical work in limited ways, while the remaining women are new to the literature of consumer activism. This book tells the story of these women as they enter the public sphere to protest the increasingly challenging task of feeding their families and balancing the household ledger.
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Yamamoto, Eric K. In the Shadow of Korematsu. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190878955.001.0001.
Texte intégralRésumé :
The national security and civil liberties tensions of the World War II mass Japanese American internment (incarceration) link 9/11 and the 2015 Paris-San Bernardino attacks to the era in America darkened by accelerating discrimination against and intimidation of those asserting rights of freedom of religion, association, and speech, and one marked by increasingly volatile protests against racial and religious discrimination. This book discusses the broad civil liberties challenges posed by these past-into-the-future linkages, highlighting pressing questions about the significance of judicial independence for a constitutional democracy committed both to security and to the rule of law. First, the book portrays the present-day significance of the Supreme Court’s discredited yet never overruled 1944 Korematsu decision—a decision later found in the coram nobis cases to be driven by the government’s presentation of “intentional falsehoods” and “willful historical inaccuracies” to the Court. Second, the book implicates prospects for judicial independence in adjudging harassment, exclusion, and incarceration disputes in contemporary America and beyond. Third, and even more broadly for security and liberty controversies, the book engages the American populace in shaping law and policy at the ground level by placing the courts’ legitimacy on center stage. It addresses how critical legal advocacy and organized public pressure targeting judges and policymakers—realpolitik advocacy—at times can foster judicial fealty to constitutional principles while promoting accountability of the elective branches. Finally it addresses who we are as Americans and whether we are genuinely committed to a checks-and-balances democracy governed by the Constitution.
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Tinker-Salas, Miguel. Venezuela. Oxford University Press, 2015. http://dx.doi.org/10.1093/wentk/9780199783298.001.0001.
Texte intégralRésumé :
Among the top ten oil exporters in the world and a founding member of OPEC, Venezuela currently supplies 11 percent of U.S. crude oil imports. But when the country elected the fiery populist politician Hugo Chavez in 1998, tensions rose with this key trading partner and relations have been strained ever since. In this concise, accessible introduction, Miguel Tinker-Salas--a native of Venezuela who has written extensively about the country--takes a broadly chronological approach to the history of Venezuela, but keeps oil and its effects on the country’s politics, economy, culture, and international relations a central focus. After an introductory section that discusses the legacy of Spanish colonialism, Tinker-Salas explores the “The Era of the Gusher,” a period which began with the discovery of oil in the early 1910s, encompassed the mid-century development and nationalization of the industry, and ended with a change of government in 1989 in response to widespread protests. Tinker-Salas also provides a detailed discussion of Hugo Chavez--his rise to power, his domestic, political and economic policies, and his high-profile forays into international relations. Arranged in helpful question-and-answer format that allows readers to search topics of particular interest, the book covers such questions as: Who is Simón Bolívar and why is he called the George Washington of Latin America? How did the discovery of oil change Venezuela’s relationship to the U.S.? What forces were behind the coups of 1992? Does Chavez really want to be president for life? How does Venezuela interact with China, Russia, and Iran? And much more. Convenient, engaging, and written by a leading expert on the country, Venezuela: What Everyone Needs to Know offers a lively look at an increasingly important player on the world stage.
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Depa, Larisse, Larissa Depa, Crhisllane Vasconcelos, Vagner Fonseca et Diego Frias. Estudo do uso de códons nos vírus da Dengue, Zika e Chikungunya com foco em terapia por inibição seletiva de tRNAs contra arboviroses. Sous la direction de Diego Mariano. Alfahelix, 2021. http://dx.doi.org/10.51780/978-6-5992753-3-3.
Texte intégralRésumé :
O vírus da dengue (DENV), o vírus da Zika (ZIKV) e o vírus da chikungunya (CHIKV) são espécies que apresentam relevância clínica para a saúde pública. Porém, ainda não existe um tratamento específico ou vacina disponível para esses arbovírus. Nesse contexto, é fundamental encontrar novos alvos terapêuticos que possam auxiliar estratégias e tratamentos mais eficientes. A metodologia de codon usage tem demonstrado bons resultados para encontrar alvos para terapias que visam inibidores de tradução. Este estudo buscou analisar o uso de códons e o equilíbrio entre a abundância relativa dos RNAs transportadores (tRNAs) para encontrar alvos terapêuticos que irão estimular novas alternativas de tratamento para infecções causadas pelos DENV, ZIKV e CHIKV. Para tanto, foi replicada uma estratégia computacional, assumindo uma terapia hipotética de inibição seletiva de tRNA (Selective Transport RNA Inhibition Therapy - STRIT), onde foi estabelecido um índice de potencial terapêutico (T-score) para encontrar potenciais espécies de tRNA que poderiam ser inibidas seletivamente para atenuar a replicação viral na célula hospedeira. Foram identificados os cinco códons com maior frequência relativa vírus/hospedeiro (mais relevantes para o vírus) nas seis espécies de arbovírus, notando que todos terminam com purinas A ou G. Os códons GGA (Glicina), AGA (Arginina) e ATA (Isoleucina) são relevantes em todos os flavivirus (ZIKV, DENV-1, DENV-2, DENV-3, DENV-4), mas não no alphavirus CHIKV, onde os códons ACG (Treonina) e CCG (Prolina) são os mais relevantes. Posteriormente, selecionando os cinco códons com maiores T-score nas seis espécies virais (30 códons em total) encontramos apenas 11 códons diferentes, todos terminados com A ou G. Agrupados segundo o nucleotídeo na primeira posição do códon estes 11 códons são: (AGA, ACA, ATA, ACG), (GGA, GCA, GTA, GCG), (CTA, CCG) e (TGG). No agrupamento, notamos outro fato intrigante: que 10 dos 11 códons mais bem ranqueados por T-score, terminam com GA, CA, TA ou CG. Nosso método identificou as espécies de tRNA (através da identificação do códon cognato com maior T-score), cuja inibição funcional por qualquer método específico a anticódon, poderia ter potenciais efeitos terapêuticos em células infectadas pelo vírus da Dengue, Zika e Chikungunya causando a inibição da tradução das proteínas do vírus sem ter um efeito deletério na sobrevivência das células hospedeiras durante o período da infeção. A predominância absoluta dos nucleotídeos A e G na terceira posição dos 11 códons com maior T-score, que por sua vez indica uma preferência dos arbovírus por 11 espécies de tRNA com C ou T na primeira posição do anticódon, abre um novo espaço de pesquisa na interação vírus-hospedeiro.