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Thèses sur le sujet « Exogenous and endogenous attention »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Taylor, Paul C. J. "Endogenous and exogenous orienting of visual spatial attention : neural systems and dynamics." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436944.

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2

Hsieh, Yi-Hsing. "Spatiotemporal characteristics of interaction between exogenous and endogenous orienting of visual attention /." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488191124571672.

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3

Wilder, Matthew. "A unified theory of exogenous and endogenous attentional control." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1460879.

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4

Jones, John Alexander. "Neural correlates of tactile attention: behavioural measures and event-related brain potentials of inhibition of return, exogenous and endogenous attention in touch." Thesis, City University London, 2011. http://openaccess.city.ac.uk/1078/.

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The studies presented in this thesis investigated the neural correlates of attention in touch. In particular, the electrophysiology of exogenous tactile processing and inhibition of return (IOR) - an area previously unexplored. In all studies a variation of the Posner cue-target paradigm was used. Typically, a cue was presented to the left or right hand. Following a stimulus onset asynchrony of 800 ms, a target would appear at the same or opposite hand. Behavioural results consistently demonstrated IOR when employing a simple target detection task, showing that IOR is a reliable phenomenon in

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5

Burnett, Katherine E. "Dimension-specific effects of endogenous and exogenous spatial cueing : indication for integration of spatial and feature-based attention." Thesis, Bangor University, 2012. https://research.bangor.ac.uk/portal/en/theses/dimensionspecific-effects-of-endogenous-and-exogenous-spatial-cueing--indication-for-integration-of-spatial-and-featurebased-attention(836d32ab-8d72-485d-8adc-130a7f57c18a).html.

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The experiments in this thesis were designed to examine the consequences of endogenous and exogenous spatial cueing in a dual-task set-up. The first experiments, presented in Chapters 2 and 3, explored whether spatial attention generalises across dimensions in the same location. Chapters 4, 5, and 6 contain a second series of experiments using exogenous cues, in which cue properties were manipulated. A dual-task set-up was used in all studies in this thesis, with a display of four random dot kinematograms containing motion and colour features. In order to examine whether endogenous attention m

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6

Kurtz, Phillipp [Verfasser], Michael [Akademischer Betreuer] Schmid, Katharine [Akademischer Betreuer] Shapcott, Jochen [Gutachter] Kaiser, Christian [Gutachter] Kell, and Michael [Gutachter] Plichta. "The influence of endogenous and exogenous spatial attention on decision confidence / Phillipp Kurtz ; Gutachter: Jochen Kaiser, Christian Kell, Michael Plichta ; Michael Schmid, Katharine Shapcott." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2019. http://d-nb.info/1196346275/34.

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7

ROSSI, VALENTINA YOLANDA. "Integrating attention, alertness and control in the brain: an electrophysiological approach." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/7831.

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Converging evidences from neurophysiological, neuropsychological and functional neuroimaging literature suggested the involvement of a large-scale fronto-parietal network in the volitional and reflexive attentional control, which enables the biological systems to select relevant portions of the input stream for facilitating processing, in order to flexibly guide behavior on the basis of internal or external goals. This system acts in tight interplay with lateralized structures deputed to the achievement and maintenance of an adequate level of arousal, and with medial frontal structures respons

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8

Mort, Dominic Jason. "From saccade to search studies in the functional organisation of exogenous and endogenous attentional control in man." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411288.

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9

Marchetti, Mauro. "Covert orienting of visuospatial attention in a brain-computer interface for communication." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422499.

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1. Introduction The multidisciplinary approach of using brain signals for directly controlling external devices, like computers or prosthesis, is named brain-computer interface (BCI). Farwell and Donchin (1988) showed that it is possible for humans to communicate using a BCI, by means of their event-related potentials (ERPs; e.g., P300), without the involvement of their voluntary muscle activity. The use of brain-wave-guided BCIs offered new perspectives regarding communication and control of devices for patients suffering from severe motor impairment or for patients who completely paralyzed

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10

Fernandez, Damien. "L'attention visuelle sélective : pertinence, saillance, résistance à l'interférence." Thesis, Lyon 2, 2010. http://www.theses.fr/2010LYO20074/document.

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Cette thèse portait sur l'attention visuelle sélective, dans le domaine non-spatial, c'est-à-dire la capacité à favoriser le traitement perceptif de certains objets de la scène visuelle au détriment des autres. En particulier, l'objectif était d'étudier, à l'aide de tâches de recherche visuelle, les différentes interactions possibles entre les processus endogènes (liés aux intentions et connaissances du sujet) et les processus exogènes (liés aux caractéristiques perceptives des objets). Une première série d'expériences démontrait que la saillance pouvait présenter des effets relativement durab

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11

Larsson, Mikael. "Endogenous and exogenous factors affecting lipoprotein lipase activity." Doctoral thesis, Umeå universitet, Fysiologisk kemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-91662.

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Individuals with high levels of plasma triglycerides are at high risk to develop cardiovascular disease (CVD), currently one of the major causes of death worldwide. Recent epidemiological studies show that loss-of-function mutations in the APOC3 gene lower plasma triglyceride levels and reduce the incidence of coronary artery disease. The APOC3 gene encodes for apolipoprotein (APO) C3, known as an inhibitor of lipoprotein lipase (LPL) activity. Similarly, a common gain-of-function mutation in the LPL gene is associated with reduced risk for CVD. LPL is central for the metabolism of lipids in b

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12

Noh, Zamira. "Bias in voting behaviour : endogenous and exogenous factors." Thesis, University of Lincoln, 2017. http://eprints.lincoln.ac.uk/28661/.

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Despite the vast research on the social bias in decision-making, relatively little is known about biases in voting behaviour. The main aim of this research was to explore alternative indirect methods to observe biases in decision-making and voting behaviour. A proximity bias was first observed in the rather unusual setting of the Weakest Link TV game show, when contestants avoided casting negative votes against their closest neighbours. This proximity bias was most profound for the contestant closest to the voter. Two field experiments were designed to test whether this Neighbour Effect occurr

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13

Kim, Ji Uk. "Empirical tests of exogenous and endogenous growth models." Connect to resource, 1995. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1265037914.

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14

Cohen, Gideon. "Methods and mechanisms of endogenous and exogenous myocardial preconditioning." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ46108.pdf.

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15

Armezzani, Alessia. "The evolutionary interplay between exogenous and endogenous sheep betaretroviruses." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3265/.

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Retroviruses must integrate their genome into the host DNA as a necessary step of their replication cycle. Normally, retroviruses integrate into somatic cells and are transmitted, from infected to uninfected hosts, as “exogenous” retroviruses. On rare occasions, they can infect germ line cells and become part of the host genome as “endogenous” retroviruses (ERVs), which are transmitted vertically to the offspring and inherited as Mendelian genes. During evolution, most ERVs have accumulated mutations that rendered them defective and unable to produce infectious viral particles. Some ERVs, howe

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16

Rutland, Catrin Sian. "Endogenous and exogenous factors affecting aberrant blood vessel formation." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403451.

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17

Arjan-Odedra, Shetal. "Regulation of exogenous retroviruses and endogenous retroelements by MOV10." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/regulation-of-exogenous-retroviruses-and-endogenous-retroelements-by-mov10(7ee91030-835b-4609-971e-f78e4e7aa0cc).html.

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Retroelements are some of the most successful parasites studied because of their ability to reverse transcribe and permanently integrate into the host genome. Host cells have, therefore, evolved multiple control mechanisms, such as cellular restriction factors, to protect their genomes from the pathogenic and mutagenic effects of retroelements. Identification of the full complement of these proteins is vital to comprehend the capacity of the host to regulate these genetic parasites. Human MOV10 is a putative RNA helicase with inhibitory or stimulatory roles in the replication of several RNA vi

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18

Low, Lucinda. "Vascular lesion development : influence of endogenous and exogenous glucocorticoids." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5920.

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Atherosclerotic and restenotic lesions develop as a result of an excess inflammatory response to vascular injury. Glucocorticoid hormones have widely-recognised anti-inflammatory and anti-proliferative properties which appear to make them ideal candidates for inhibition of vascular lesion development. Indeed, administration of glucocorticoids to experimental animals does inhibit the growth of vascular lesions in some models. In addition, glucocorticoids are currently being trialled clinically as anti-restenotic agents. However, glucocorticoid excess in patients, either as a result of Cushing’s

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19

SCHMID, KARA E. "ENDOGENOUS AND EXOGENOUS SOURCES OF CHOLESTEROL DURING FETAL DEVELOPMENT." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1061304521.

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20

Kelly, Solange. "Energy systems improvement based on endogenous and exogenous exergy destruction." Düsseldorf VDI-Verl, 2008. http://d-nb.info/989105776/04.

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21

Oyewo, E. A. "A study of exogenous and endogenous pyrogens in malaria fever." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377667.

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22

Fultz, Dalen R. "The Silencing of Endogenous and Exogenous Transposable Elements in Arabidopsis." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492468003210374.

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23

Gallo, Paul Matthew. "The Dendritic Cell Response to Exogenous and Endogenous Danger Signals." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/452916.

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Microbiology and Immunology<br>Ph.D.<br>Systemic lupus erythematosus (SLE) is complex autoimmune disease in which autoantibodies form against double stranded DNA (dsDNA) and nuclear antigens. Autoantigen immune complexes form, deposit in the vasculature, and cause multisystem organ damage. Both genetic and environmental factors contribute to the development of SLE. This thesis will explore three major themes found in the study of SLE: 1) Bacterial infection as an environmental trigger, 2) cytokine dysregulation in immune cells, and 3) the treatment of end organ damage in the form of lupus neph

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24

Asci, Murtaza. "Periodic-review Inventory Systems With Exogenous And Endogenous Replenishment Lead Times." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609129/index.pdf.

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In this thesis, two-echelon systems with exogenous and endogenous lead times are studied for the orders placed by the retailer(s) from the supplier. The retailer(s) employ periodic-review base-stock policy, namely (R,S) policy. For the case the demand during review period is i.i.d. and the probability distribution is Normal for each review period, a new method is proposed for exogenous lead time case under stationary policy. The results of the proposed method is then compared with the results of the existing methods in the literature and it is concluded that the proposed method provides servic

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25

Sallinen, P. (Pirkko). "Myocardial infarction:aspects relating to endogenous and exogenous melatonin and cardiac contractility." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514287558.

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Abstract Melatonin is an important modulator of several physiological and behavioural processes, and it influences the function of many different tissues. Melatonin has effective antioxidative properties, but some of its actions in mammals are also mediated through the MT1 and MT2 melatonin receptors. Antioxidative properties are seen especially when the melatonin concentration is high (≥ nM), and melatonin's affinity for its receptors appears at lower concentrations (pM). Recently, the involvement of melatonin in protecting the heart against cardiac diseases, including myocardial infarction (

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26

Pettit, Alexandra S. "Investigating the Regulation of Adult Hippocampal Neurogenesis: Endogenous and Exogenous Cues." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23347.

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The discovery of stem and progenitor cells capable of ongoing neurogenesis in the adult mammalian brain has raised hope that we will one day be able to harness their intrinsic regenerative capacity following injury. Development of such therapeutic strategies relies on a comprehensive understanding of the underlying regulation of the neurogenic process. To this end, I show, in this thesis, that cultured post-natal hippocampal neural progenitor cells (NPCs) express a specific repertoire of connexins (Cx), a family of channel forming proteins critical for communication prior to the development

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27

LeSage, James P., and Manfred M. Fischer. "Spatial Regression-Based Model Specifications for Exogenous and Endogenous Spatial Interaction." WU Vienna University of Economics and Business, 2014. http://epub.wu.ac.at/4271/1/SSRN%2Did2420746.pdf.

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The focus here is on the log-normal version of the spatial interaction model. In this context, we consider spatial econometric specifications that can be used to accommodate two types of dependence scenarios, one involving endogenous interaction and the other exogenous interaction. These model specifications replace the conventional assumption of independence between origin-destination-flows with formal approaches that allow for two different types of spatial dependence in flow magnitudes. Endogenous interaction reflects situations where there is reaction to feedback regarding flow magnitudes

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Laswai, Henry Sarimbo. "The role of exogenous and endogenous proteases in processing of sorghum." Thesis, University of Reading, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315782.

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29

Taylor, Alexander John. "Molecular MRI using exogenous enzymatic sensors and endogenous chemical exchange contrast." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/35819/.

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Molecular magnetic resonance imaging (MRI) methods have the potential to provide detailed information regarding cellular and molecular processes at small scales within the human body. Nuclear signals from chemical samples can be probed using specialised MRI techniques, to highlight molecular contrast from particular enzymes or metabolites. The aim of the work described in this thesis is to investigate both exogenous and endogenous contrast mechanisms using fluorine MRI and chemical exchange saturation transfer (CEST) respectively, in order to detect molecular changes in vitro. Initial theoreti

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Parks, Ashley Joan. "Modulation of the aryl hydrocarbon receptor by endogenous and exogenous ligands." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12830.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>This year it is estimated that over 34,000 American women will be diagnosed with triple-negative breast cancer (TNBC), an aggressive disease resistant to current targeted therapies. Consequently, development of

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31

Monroy, Carlos Aaron. "Endogenous and exogenous modulation of regulator of G-protein signaling 4." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1366.

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Regulators of G-protein signaling (RGS) proteins are a family of proteins that act as GTPase accelerating proteins (GAPs) through their interaction with GΑ subunits, including GΑo, GΑi, and GΑq but not GΑs. This increased rate of hydrolysis of GTP to GDP temporally regulates G-protein coupled receptor (GPCR) signaling. A member of this family, RGS4, has been implicated in several neurological disorders including Parkinson's Disease (PD). A hallmark of PD is the induction of oxidative stress within dopaminergic neurons. In this thesis, we evaluate the role of oxidative stress, including lipid p

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32

Polverigiani, Serena. "Endogenous and exogenous factors affecting root morphology and metabolism in olive." Doctoral thesis, Università Politecnica delle Marche, 2011. http://hdl.handle.net/11566/241959.

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La gestione razionale di impianti moderni ed intensivi richiede un utilizzo delle risorse improntata alla massimizzazione degli assorbimenti ed al mantenimento degli equilibri morfologici e funzionali. Molte delle pratiche agronomiche vedono il loro effetto mediato dall’interazione con l’apparato radicale. Una conoscenza delle conseguenze morfologiche, architetturali, anatomiche e metaboliche che i fattori ambientali hanno sullo sviluppo radicale è pertanto imprescindibile ad un raggiungimento sostenibile degli obiettivi produttivi. L’azione di fattori esogeni si combina inevitabilmente con a

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33

Fong, Lai-ping Iris. "Modulation of dendritic cell differentiation, maturation by exogenous and endogenous "danger" signals." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971015.

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Gommans, Willemijn Maria. "Exogenous and endogenous gene regulation for specific and efficient cancer gene therapy." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/298375389.

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Fong, Lai-ping Iris, and 方麗萍. "Modulation of dendritic cell differentiation, maturation by exogenous and endogenous "danger" signals." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31971015.

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36

Watson, Christopher. "Interactions of endogenous and exogenous molecules with the human blood-brain barrier." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/interactions-of-endogenous-and-exogenous-molecules-with-the-human-bloodbrain-barrier(f89b9f10-b55a-4681-9858-b929d442d184).html.

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The BBB is a biological firewall that carefully regulates the cerebral microenvironment by acting as a physical, metabolic and transport barrier to molecules bound for the brain. This selectively permeable interface was modelled in this thesis using the recently established immortalised human cerebral microvascular endothelial cell line (hCMEC/D3) to investigate interactions with endogenously and exogenously derived molecules of clinical significance. The endogenous molecules in question are the cationic amino acids (CAA) L-arginine, the precursor for nitric oxide (NO), and asymmetric dimethyl

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Alqasim, Abdulmonim Ahmed. "Determinants of vascular responsiveness to endogenous and exogenous activators of guanylate cyclases." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445259/.

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This thesis describes studies to investigate the regulation of guanylate cyclases pathways in blood vessels. Endogenous iS-nitrosothiols have been implicated in the regulation of soluble guanylate cyclase (sGC), by modulating nitric oxide (NO) bioactivity. To determine whether the biotransformation of S-nitrosothiols by isolated rat aorta is enzyme-dependent, stereoisomers of S-nitrosoglutathione (GSNO), S-nitrosocysteine (CYSNO) and 5-mtroso-N-acetyl-pemcillamine (SNAP) were synthesised and their decomposition and relaxant effects characterised. Decomposition of these S-nitrosothiol stereoiso

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Giannelos, Spyridon (Spyros). "Option valuation of smart grid technology projects under endogenous and exogenous uncertainty." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/45309.

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Electricity demand and renewables penetration are set to increase worldwide over the coming decades as part of the global decarbonisation effort. As a result, distribution networks are expected to face challenges related to increased peaks and undesirable voltage excursions. Hence, significant network reinforcements may be required over the next decades. However, a very significant challenge in realizing this transition is the increased uncertainty that surrounds future distributed generation and load connections in terms of size, location and timing. This uncertainty inadvertently will give r

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Bujny, Miriam Verena. "Intracellular logistics : sorting nexins in retrograde transport of endogenous and exogenous cargo." Thesis, University of Bristol, 2007. http://hdl.handle.net/1983/52180249-a64e-48b1-976e-52e7effa5ee9.

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Freund, Roman. "Karaites and dejudaization : a historical review of an endogenous and exogenous paradigm." Doctoral thesis, Stockholm : Almqvist & Wiksell, 1991. http://catalogue.bnf.fr/ark:/12148/cb35483354w.

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Wheatley, Courtney M. "Endogenous and Exogenous Regulation of Exhaled Ions in Patients with Cystic Fibrosis." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293489.

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Exercise has become a vital component of the therapy regimen prescribed to cystic fibrosis (CF) patients due to its systemic benefits, such as increased sputum expectoration, attenuation of the expected 2-3% annual decline in pulmonary function, and extended life expectancy. However, exercise still is not viewed as being as beneficial as pharmacological treatments by many CF patients and can be intimidating. My aims in this study were two-fold; first, to determine the ideal exercise intensity for individuals with CF; and second, to determine if exercise at this ideal intensity could provide i

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Dixon, Wallace E. Jr, and Hannah G. Lawman. "Effects of Exogenous and Endogenous Distraction on Long-Term Recall in Toddlers." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/4929.

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Gallant, Megan. "In vitro effects of endogenous and exogenous cannabinoids on insulin resistance and secretion." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1076.

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Type 2 diabetes mellitus results from a combination of insulin resistance and impaired insulin secretion. The aim of this study is to investigate the effect of endogenous and exogenous cannabinoids on insulin resistant cell lines, viz skeletal muscle (C2C12) and fat (3T3-L1), and to investigate the effects of these cannabinoids on insulin secretion in pancreatic β-cells (INS 1). Insulin resistance was induced in the cells using 20 ng/mL TNF-α (3T3-L1) and 100 nM insulin (C2C12). Insulin resistant cells were exposed to cannabinoids for 48 hours after which glucose uptake, RT-PCR and Western blo

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Wright, Tracey Jane. "Characterisation of CD23 cleavage by endogenous and exogenous proteases using neo-epitope antibodies." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29820.

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CD23 is the low affinity IgE receptor. It is a type II integral transmembrane glycoprotein that can be shed from the cell surface forming soluble products of approximately 37, 33, 29, 25 and 16kDa. It appears that membrane and soluble CD23 have opposing regulatory functions and that inhibition of CD23 shedding may have potential to alleviate both allergic and inflammatory diseases. This has focused attention on the endogenous protease(s) responsible for CD23 shedding, leading to the demonstration that both the 37 and 33kDA sCD23 fragments are cleaved from the cell surface by a metalloprotease.

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Scott, Chris G. "A comparison of endogenous versus exogenous heating on the subsequent development of hypothermia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58502.pdf.

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Selinger, Elizabeth. "Lipoprotein (a) is present in TG-rich fraction in endogenous and exogenous hypertriglyceridemia." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60505.

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The aim of this study was to examine apo(a)B particles distribution among plasma lipoproteins in two situations in which triglyceride-rich lipoproteins are increased: in normolipidemic subjects after a fat load and in patients with endogenous hypertriglyceridemia.<br>The results obtained demonstrate that, in hypertriglyceridemic patients, the distribution of apo(a)B particles among lipoprotein fractions is different than that observed in normotriglyceridemic subjects. These differences in distribution are a result of the association of apo(a)B particles with TG-rich lipoproteins. Contrary to a

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47

Bell, Katrina Margaret. "A biochemical and pharmacological characterisation of some endogenous and exogenous κ opioid ligands". Thesis, Loughborough University, 1994. https://dspace.lboro.ac.uk/2134/12053.

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An investigation of the interaction of stable opioid/ligands and unstable opioid peptides with opioid receptors in guinea pig brain, guinea pig myenteric plexus and mouse vas deferens has been carried out. The initial aim of the study was to further characterise K opioid receptors, using binding assays and isolated tissue bioassays. The second aim was to determine the true affinity and potency of small dynorphin peptides for the K opioid receptor and to determine if metabolism of the peptides to non K opioid receptor-preferring products contributes to their observed in vitro pharmacology.

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Scott, Christopher G. "A comparison of endogenous versus exogenous heating on the subsequent development of hypothermia." Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9344.

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This study investigated the effect of endogenous and exogenous heating on body core cooling rate, afterdrop and re-warming rate in humans during subsequent cold-water immersion. On three separate days, following 30 min baseline resting at an ambient temperature of 25°C, seven subjects were either: (1) seated upright for 15 min rest (Control); (2) exercised 15 min on a cycle ergometer at 70% VO2 max (Exercise); or, (3) immersed 16.8 +/- 6.2 min in warm water (40°C) (Warm-water immersion) to an esophageal temperature (TES) similar to that of end of exercise. Subjects were then cooled in water (7

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Apap, Robert M. "Models and Computational Strategies for Multistage Stochastic Programming under Endogenous and Exogenous Uncertainties." Research Showcase @ CMU, 2017. http://repository.cmu.edu/dissertations/1002.

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This dissertation addresses the modeling and solution of mixed-integer linear multistage stochastic programming problems involving both endogenous and exogenous uncertain parameters. We propose a composite scenario tree that captures both types of uncertainty, and we exploit its unique structure to derive new theoretical properties that can drastically reduce the number of non-anticipativity constraints (NACs). Since the reduced model is often still intractable, we discuss two special solution approaches. The first is a sequential scenario decomposition heuristic in which we sequentially solve

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Vanderah, Todd William. "The direct and modulatory antinociceptive actions of endogenous and exogenous opioid delta agonists." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187190.

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Opioids are responsible for a number of effects but are employed primarily as analgesics. The discovery of endogenous opioids and multiple receptors have led to a better understanding of how analgesics function, and how both opioid receptors and endogenous ligands are regulated. The hypothesis of this dissertation states that levels of endogenous enkephalins are modulated by stress, inflammation and the endogenous peptide cholecystokinin (CCK) to alter the antinociceptive efficacy of μ and, possibly, δ opioids. Endogenous enkephalin release results in either direct antinociception or synergist

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