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Thèses sur le sujet « Fibrosi renale »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Bedino, Giulia <1980&gt. "La terapia combinata di cellule mesenchimali stromali e aceinibitori riduce la fibrosi renale in un modello animale di ostruzione ureterale unilaterale." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6297/1/bedino_giulia_tesi.pdf.

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Le cellule mesenchimali stromali (MSC) sono cellule multipotenti e numerosi studi hanno mostrato i loro effetti benefici nel danno renale acuto ma non sono ancora stati dimostrati potenziali effetti nella malattia renale cronica. L'ostruzione ureterale unilaterale (UUO) è un modello di fibrosi interstiziale nel quale l'attivazione di molecole vasoattive, citochine profibrotiche e infiammatorie gioca un ruolo patogenetico nello sviluppo dell'apoptosi e atrofia tubulare. Il sistema renina-angiotensina (RAS) gioca un ruolo chiave nello sviluppo della fibrosi renale e i farmaci che hanno come tar

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2

Bedino, Giulia <1980&gt. "La terapia combinata di cellule mesenchimali stromali e aceinibitori riduce la fibrosi renale in un modello animale di ostruzione ureterale unilaterale." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6297/.

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Le cellule mesenchimali stromali (MSC) sono cellule multipotenti e numerosi studi hanno mostrato i loro effetti benefici nel danno renale acuto ma non sono ancora stati dimostrati potenziali effetti nella malattia renale cronica. L'ostruzione ureterale unilaterale (UUO) è un modello di fibrosi interstiziale nel quale l'attivazione di molecole vasoattive, citochine profibrotiche e infiammatorie gioca un ruolo patogenetico nello sviluppo dell'apoptosi e atrofia tubulare. Il sistema renina-angiotensina (RAS) gioca un ruolo chiave nello sviluppo della fibrosi renale e i farmaci che hanno come tar

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3

Mezzalira, Giorgia. "Studio delle patologie renali del cane." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3425666.

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This study selected 40 canine patients with signalement, anamnesis, lab exams and renal biopsy or renal sample taken during necropsy. Renal sections stained with H&E, PAS, PASM, Masson's Thrichrome and AFOG was evaluated by three independent pathologists. Later, morphological diagnoses were correlated with lab exams.<br>Questo studio ha selezionato 40 cani completi di segnalamento, anamnesi, esami di laboratorio e campione bioptico renale prelevato tramite biopsia o post mortem, in sede necroscopica. Le sezioni istologiche ottenute e colorate con ematossilina ed eosina, PAS, PASM, Tricromica

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4

CORRADI, BARBARA. "Ruolo di N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) nella progressione della Nefropatia Diabetica." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/43715.

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La nefropatia diabetica è la principale causa di insufficienza renale terminale. N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP), tetrapeptide fisiologicamente presente nel plasma e nei tessuti, viene idrolizzato dall’ enzima di conversione dell’angiotensina. Il tetrapeptide ha un effetto antifibrotico sul sistema cardiovascolare e nel rene in modelli sperimentali di ipertensione, infarto del miocardio e nefropatie. Lo scopo del nostro lavoro è stato studiare gli effetti antifibrotici di Ac-SDKP in un modello sperimentale di nefropatia diabetica, e il potenziale effetto additivo del tetrapepti

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5

Yi, Hao. "The Effect of Metformin on Inflammatory and Fibrotic Responses in Renal Fibrosis." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21855.

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Chronic kidney disease (CKD) is a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease, and premature death. It is well recognised that renal fibrosis is the unifying pathology in almost all forms of progressive CKD. To date, kidney transplantation and dialysis are the only options for the management of end-stage kidney disease, which results in a significant burden on the health system. Hence innovative strategies are needed to both prevent and treat CKD. It is well recognised that inflammatory pathways play a central role in the progression of CKD

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6

DaSilva, Santos Iara Karlla. "Impacto de la inflamación y fibrosis en la función del injerto renal." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/666855.

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A pesar de los grandes avances en el campo del trasplante renal (TR), los resultados a largo plazo aún no son óptimos. Varios estudios han demostrado que diversos factores como la inflamación precoz y/o la presencia de fibrosis intersticial (FI) están asociados a un peor pronóstico del injerto, pero todavía se trata de un tema controvertido. En este estudio analizamos el estado inflamatorio (Banff, macrófagos CD68+, fenotipos de macrófagos M1-M2) y la expresión génica de múltiples factores relacionados con la inflamación y FI (TGF-β1, metaloproteinasas, proteínas de matriz extracelular, entre

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7

Bigé, Naïke. "Rôle de la Thrombospondine-1 et du récepteur CD47 dans le développement de la fibrose rénale." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066705/document.

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La Thrombospondine-1 (TSP-1) représente l'un des principaux activateurs endogènes du TGF-?1 et possède des propriétés anti-angiogéniques et immunomodulatrices. L'un de ses récepteurs, le CD47, joue un rôle critique dans son effet anti-angiogénique et module l'inflammation. Après obstruction urétérale unilatérale (UUO), l'expression de la TSP-1 augmente, est corrélée à celle du TGF-?1 et du collagène III et décroît avec la réparation tissulaire qui accompagne la désobstruction urétérale. L'utilisation de souris knock-out pour la TSP-1 a permis de montrer qu'elle participe au développement des l

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8

Pat, Betty Kila. "Signal transduction pathways in renal fibrosis /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17739.pdf.

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9

Winbanks, Catherine, and winbanks@unimelb edu au. "Novel Aspects of Renal Tubulointerstitial Fibrosis." RMIT University. Medical Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080617.143850.

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Tubulointerstitial fibrosis is the key histological predictor of the progression of declining renal function and the final common pathway of progressive kidney disease, regardless of aetiology. Despite its significance, there are currently no treatments available to abrogate this process and those that suffer with this burden eventually succumb to renal failure. Tubulointerstitial fibrosis is largely mediated by fibroblasts and myofibroblasts present in the interstitium. In response to injury, activated fibroblasts differentiate into myofibroblasts which serves as a histological hallmark of

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10

Krupa, Aleksandra. "Role of microRNAs in renal fibrosis." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54361/.

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This thesis examines the role of microRNAs in renal fibrosis. MicroRNAs constitute a large family of approximately 22-nucleotide-long non-coding RNAs, that in animal cells regulate gene expression posttranscriptionally. At the start of the project, microRNAs were emerging as potentially important factors in various physiological and pathological processes however, there was very little known about their expression and function in the kidney, in particular in tubulointerstitial fibrosis. In this thesis, global microRNA expression has been analysed in vitro in proximal tubular epithelial cells,

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11

Peters, Harm. "Wirkungen der L-Arginingabe bei immun-vermittelter akuter und chronischer Glomerulofibrose." Doctoral thesis, [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960841733.

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12

McSorley, Anita D. "Renal stones in adults with cystic fibrosis." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509862.

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13

Baelde, Jacobus Johannes. "Fibrogenesis in progressive renal disease /." [S.l. : s.n.], 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014983980&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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14

Contti, Mariana Moraes. "Transplante renal associado a redução de fibrose miocárdica estudo de ressonância magnética /." Botucatu, 2018. http://hdl.handle.net/11449/180625.

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Orientador: Luis Gustavo Modelli de Andrade<br>Resumo: RESUMO: A ressonância magnética cardíaca (RMC), usando o T1 nativo, é considerado método não invasivo para avaliar fibrose miocárdica sem necessidade de usar contraste paramagnético. Até o momento não há dados a respeito do T1 nativo após o transplante renal. O objetivo primário deste estudo foi avaliar mudanças no T1 nativo do miocárdio, seis meses após o transplante renal. Foram analisados prospectivamente, 44 pacientes transplantados renais, os quais foram submetidos a 2 exames de RMC (3T): o 1º nos 10 dias inicias do transplante, e o 2

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15

Nawafa, Lotfia Shames Omar. "The contribution of methyltransferases/demethylases to renal fibrosis." Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/4111.

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TGF β-1 signalling regulates many cellular processes, including proliferation, differentiation, apoptosis, immune responses, and fibrogenesis. The essential role of TGF β-1/SMAD signalling in stimulating fibrogenic cells to produce extra cellular matrix proteins and promoting proliferation of myofibroblasts is widely recognised. SMAD3 is known as a mediator in TGF β- 1-induced fibrosis in the kidney. Upon activation of TGF-β receptors, SMAD2 and SMAD3 are phosphorylated and form cytoplasmic heteromeric complexes with SMAD4. These complexes translocate to the nucleus where they regulate express

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16

Vernon, Madeleine Anne. "Myofibroblast loss during renal remodelling." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/9939.

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Renal fibrosis, the final endpoint of renal disease of any cause, is characterised by myofibroblast deposition of extracellular matrix (ECM) and commonly studied using the unilateral ureteric obstruction (UUO) model. Macrophages are multifunctional cells and involved in renal injury, repair and scarring. Work in other organs has shown that fibrosis is not necessarily irreversible and we established and characterised the murine model of reversible unilateral ureteric obstruction (R-UUO) to investigate the potential reversibility of fibrosis and the underlying mechanism with a particular focus u

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17

Takase, Masayuki. "Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice." Kyoto University, 2014. http://hdl.handle.net/2433/188704.

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18

Newbury, Lucy Jade. "Targeting Ras GTPases in murine models of renal fibrosis." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/targeting-ras-gtpases-in-murine-models-of-renal-fibrosis(01debcfb-6d17-4452-b142-e686eb9d059e).html.

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End stage kidney disease (ESKD) affects over 5300 people. The progression of chronic kidney disease (CKD) to ESKD is characterised by cytokine stimulation, leading to the activation of myofibroblasts, resulting in fibrosis. Kirsten rat sarcoma (KNRas) has a key role in the proliferation of renal fibroblasts in vitro and has been highlighted as a possible target for fibrosis. Previous research in our laboratory showed that inhibiting KNRas in the UUO model inhibited renal fibrosis. The aim of this thesis was to investigate the outcome of inhibiting KNRas using Antisense Oligonucleotide (ASO) in

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19

Sharpe, Claire Catherine. "The role of the Ras monomeric GTPases in renal fibroblast proliferation." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271197.

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20

LAVAUD, STEPHANIE. "Mediateurs de la fibrose renale : etude che zle rat zucker et chez l'homme." Paris 6, 1997. http://www.theses.fr/1997PA066418.

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Le rein subit des alterations morphofonctionnelles, plus ou moins importantes, au cours du vieillissement, caracterisees principalement par une glomerulosclerose diffuse, des lesions de hyalinose segmentaire et focale des glomerules, des lesions tubulaires et une fibrose interstitielle. Dans un premier temps, par des techniques d'histologie, de biologie moleculaire et de morphometrie, nous avons montre que, chez le rat zucker obese, les lesions de glomerulosclerose apparaissent entre 6 et 9 mois et qu'elles s'accompagnent d'une augmentation de taille des glomerules due a une forte expansion du

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21

Block, Daniel Bueno 1982. "Fumo em ratas grávidas : envolvimento do fator induzível por hipóxia (HIF-1alpha), do fator de crescimento do endotélio vascular (VEGF) e da eritropoietina (EPO) sobre a ontogênese renal e a função renal da prole de ratos machos." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309930.

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Orientadores: José Antonio Rocha Gontijo, Flávia Fernandes Mesquita Vieira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-24T00:59:05Z (GMT). No. of bitstreams: 1 Block_DanielBueno_M.pdf: 3824410 bytes, checksum: 3f680ece69f85c5b515f67c4ee1f67b4 (MD5) Previous issue date: 2013<br>Resumo: O ambiente em que vivemos tem grande influência no desenvolvimento e na vida adulta do feto, sendo que a alimentação ou o tabagismo vêem como hábitos e estilo de vida que estão diretamente relacionados a modificações na orga

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22

Glanville, Michael. "The molecular basis of renal tubular anion secretion." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273477.

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Lecru, Lola. "Les récepteurs cannabinoïdes : une nouvelle cible thérapeutique de la fibrogenèse rénale." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T088.

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L’insuffisance rénale chronique et la dysfonction chronique de l’allogreffe (DCA) sont associées à la fibrogenèse rénale, qui représente un enjeu majeur en santé publique et nécessite l’exploration de nouvelles cibles thérapeutiques. Dans ce contexte, nous avons étudié l’expression des gènes modulés au cours d’un modèle reconnu de fibrogenèse chez la souris (le modèle d’obstruction urétérale unilatéral, ou OUU). L'expression du gène codant pour le récepteur cannabinoïde apparait sept fois augmentée dans les reins pathologiques comparée à leurs contrôles internes. L’expression du récepteur est

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24

Yokoi, Hideki. "Role of connective tissue growth factor in renal tubulointerstitial fibrosis." Kyoto University, 2005. http://hdl.handle.net/2433/144757.

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Braga, Tárcio Teodoro. "Participação de diferentes subtipos de macrófagos e a contribuição do ácido úrico solúvel, dos receptores TLR2 e TLR4 e das moléculas MyD88 e NLRP3 para o desenvolvimento da fibrose renal." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-24092014-184133/.

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A doença renal crônica é uma doença mediada pelo sistema imune e caracterizada por fibrose. Camundongos deficientes em TLR2, TLR4, MyD88 e NLRP3 se mostraram protegidos frente ao dano renal e à deposição de colágeno após serem submetidos à obstrução unilateral do ureter (UUO). Além disso, os camundongos protegidos exibiram menor produção de citocinas relacionadas com um perfil imune Th2 e apresentaram menor acúmulo de macrófagos do subtipo M2. Inicialmente, creditamos aos macrófagos M2 o papel de macrófagos formadores de fibrose uma vez que tal subpopulação é encontrada em maior número aos set

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Jan, Budour H. 1984. "The Role of Kindlin-2 in the progression of renal fibrosis." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/543848.

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Chronic kidney disease (CKD) is usually characterized by histological lesions of glomerulosclerosis and tubulointerstitial fibrosis (TIF). The progressive TIF is mediated by multiple mediators such as growth factors, metabolic toxins and stress molecules. One of the key mediators of this process is TGF-1 that induces cellular responses in a wide variety of cell types. In renal tubular cells TGF-1 activation requires the binding of Kindlin-2 to the TGF-1 receptor. The expression of Kindlin-2 was assessed in three different situations and correlated with the progression of the renal fibrotic

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27

Klinkhammer, Barbara Mara [Verfasser]. "Zell-basierte Ansätze zur Therapie der renalen Fibrose / Barbara Mara Klinkhammer." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1065847890/34.

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Shi, Ying. "Targeting receptor-interacting serine/threonine-protein kinase (RIPK)3 in renal tubulointerstitial fibrosis." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20195.

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Chronic kidney disease (CKD) affects almost 10% of the adult population worldwide. Regardless of the initial cause of renal injury, renal fibrosis is the final common pathway of all forms of CKD, including diabetic kidney disease (DKD). However, current therapies to attenuate the development of progressive renal fibrosis are limited to blockade of the renin-angiotensin-aldosterone system (RAAS), achievement of blood pressure targets and in the case of DKD, blood glucose control. More recently inhibition of sodium-glucose linked transporter-2 has shown impressive renoprotective benefits in seco

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Kapoor, Rishab. "Investigating the mechanisms of renal fibrosis following ischaemia and reperfusion injury." Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/4117.

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Ischaemia-reperfusion injury (IRI) is the major cause of acute kidney injury (AKI) and predisposes to the development of chronic kidney disease (CKD). The role of TGF-β in extracellular matrix deposition and renal fibrosis has been well established. This study was designed to establish an in vitro model of renal tubular IRI, evaluate the role of TGF-β in IRI in human proximal tubular epithelial cells (HKC8 and HK2 cells) and further determine the role of αvβ6 integrin in IRI. Initially an in vitro model of hypoxia and free radical stress by treating HKC8, HK2 and fibroblasts (MRC-5 cells) with

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Oguntona, Taiwo Shola. "The potential role of a carboxypeptidase B2 inhibitor in renal fibrosis." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19949/.

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Diabetic nephropathy (DN) is a fibrotic disease from renal injury which is characterized by extracellular matrix (ECM) build-up. Thus, DN leads to disruption of renal architecture and loss of renal function. We hypothesized that renal fibrosis can be improved by increasing plasmin activity through inhibition of carboxypeptidase B2 (CPB2) activity using UK-396082- a selective CPB2 inhibitor. An in vivo rat model of DN was used. Unilateral nephrectomy and induction of type 1 diabetes with 80mg/kg streptozotocin injection. Blood glucose was maintained between 20-25 mM for 8 months with linplants.

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Oliveira, Fabiana Aparecida Mayrink de. "O efeito do laser de baixa intensidade na fibrose intersticial renal." Universidade Federal de Juiz de Fora, 2011. https://repositorio.ufjf.br/jspui/handle/ufjf/2129.

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Zimmerman, Danielle. "The Role of Angiotensin-(1-7) in a Mouse Model of Renal Fibrosis." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23692.

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Angiotensin-(1-7) [Ang-(1-7)] is a heptapeptide component of the renin angiotensin system and the endogenous ligand for the Mas receptor. Ang-(1-7) is generated mainly via angiotensin converting enzyme 2 (ACE2)-dependent cleavage of Angiotensin (Ang) II. Studies suggest Ang-(1-7) may protect against progression of renal injury in experimental models of chronic kidney disease, although the responses may be dose dependent. The role of Ang-(1-7) in the progression of renal fibrosis in unilateral ureteral obstruction (UUO) remains unclear. We tested the hypothesis that endogenous Ang-(1-7) and low

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Pereira, Rafael Canavel. "Influência da sobrecarga de sódio em ratos submetidos à isquemia e reperfusão renal: tratamento com N-acetilcisteína." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-12092018-090042/.

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A injúria renal aguda (IRA) é uma complicação renal que necessita de tratamento com urgência, gerando gastos de bilhões de dólares na saúde pública de diversos países. Dentre os tipos mais comuns de IRA é a IRA isquêmica causada por perfusão abaixo do normal ao tecido renal, gerando maior produção de espécies reativas de oxigênio (ROS), ativação do sistema renina angiotensina aldosterona (SRAA) local, necrose tubular aguda (NTA). O tratamento com o antioxidante N-acetilcisteína (NAC) tem resultados positivos em diversos modelos de lesão renal. Ao reestabelecer a função renal após a IRA, os pac

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34

Chakrabarti, Shubro. "Mechanisms of fibrosis in feline chronic kidney disease." Thesis, Royal Veterinary College (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572451.

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Al, Hasan Abd Alrasol. "The role of 6-0-sulphated heparan sulphate in chronic renal fibrosis." Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1725.

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Heparan sulphate (HS) plays crucial roles during the genesis and resolution of inflammation by sequestration, stabilization and presentation of proinflammatory cytokines and growth factors. The interaction between many of these factors and HS is critically dependent on the variable distribution of anionic 6-O-sulphated glucosamine residues within the structure of HS. The pattern of 6-O-sulphation is generated during HS biosynthesis by HS-6-O-sulphotransferases (HS6STs) but can be modified later by cell-surface HS-6-O-endosulphatases (SULFs). This study was designed to examine the potential con

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Menon, Vasudev Ramdas. "Analysis of the role and regulation of disintegrin metalloproteases in renal fibrosis." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3872/.

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Chronic Kidney Disease (CKD) affects about 10-20% of the adult population of the developed world. The underlying molecular mechanisms contributing to its varied pathophysiology CKD are still unclear. Without early diagnosis and therapeutic intervention, patients with CKD risk progressing to end stage renal failure (ESRF) requiring renal replacement therapy such as dialysis and eventually a renal transplant. Tubulointerstitial fibrosis is the common end point in most progressive renal diseases and has consistently been shown to be the best histological predictor of progression towards end stage

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Soofi, Abdulsalam. "Pathways that regulate renal development, fibrosis, and metabolic disease in mouse models." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/102838/.

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The kidney is an essential organ that maintains homeostasis, maintains water and mineral balance, and removes metabolic waste products from the body. In mammals, the kidney derives from the intermediate mesoderm (IM) and develops through a multistep process where undifferentiated mesenchyme is converted into a highly complex organ. Several transcriptional regulators, including the Pax2 gene, have been identified in the specification and maintenance of this multistep process. The Pax2 gene marks the IM shortly after gastrulation, when the mesoderm becomes compartmentalized into paraxial, interm

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Smith, Stuart William. "The role of CD248+ stromal cells in the pathogenesis of renal fibrosis." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3337/.

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Chronic kidney disease affects 10-13% of the population. The dominant processes that promote kidney disease, irrespective of the trigger, occur in the stromal compartment where fibrosis is considered the hallmark of progressive renal disease. Recent studies have highlighted the importance of the vasculature and the role of the renal pericyte as a progenitor of activated matrix-depositing stromal myofibroblasts, cells that drive the development of renal fibrosis. CD248 is a 175 KDa type I transmembrane glycoprotein expressed at low levels in non-inflamed kidney by resident renal stromal cells (

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Tyra, Paula Marie [Verfasser], Jürgen [Akademischer Betreuer] Floege, and Peter [Akademischer Betreuer] Boor. "Collagen expression in renal fibrosis / Paula Marie Tyra ; Jürgen Floege, Peter Boor." Aachen : Universitätsbibliothek der RWTH Aachen, 2021. http://d-nb.info/1240390912/34.

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Konstas, Angelos Aristeidis. "The regulation and functional interaction of the epilethial sodium channel (ENaC) and renal potassium channels." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249463.

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Magalhães, Andréa Olivares. "Papel do fósforo e do paratormônio na progressão da doença renal crônica." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-04042008-142314/.

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Introdução: Os mecanismos envolvidos na progressão da doença renal crônica (DRC) independentemente de sua etiologia, não estão totalmente esclarecidos. O controle do fósforo(P) sérico é uma meta essencial a ser alcançada no tratamento de pacientes com DRC. Inicialmente, a importância deste controle era atribuída a participação do P na patogênese do hiperparatireoidismo secundário. Atualmente sabe-se que a hiperfosfatemia aumenta a mortalidade desses pacientes. Distúrbios do metabolismo mineral participam da progressão da DRC, porém os mecanismos envolvidos na fisiopatologia, não foram esclarec

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Van, Der Hauwaert Cynthia. "Déterminants moléculaires de la néphrotoxicité induite par le tacrolimus après transplantation rénale." Thesis, Lille 2, 2014. http://www.theses.fr/2014LIL2S033/document.

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Bien que le Tacrolimus soit un immunosuppresseur largement prescrit en transplantation rénale, ses effets néphrotoxiques limitent son utilisation. En effet, le Tacrolimus contribue au développement de lésions de fibrose interstitielle rénale et d’atrophie tubulaire à plus ou moins brève échéance. Parmi les mécanismes qui interviennent dans le processus de fibrogenèse, la transition épithélio-mésenchymateuse (TEM) a été évoquée. Dans ce processus, une cellule épithéliale polarisée perd l’expression de certains de ses marqueurs épithéliaux (E-cadhérine, cytokératine, β-caténine membranaire.

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Stangenberg, Stefanie. "Fetal programming of chronic kidney disease and novel treatment targets of renal fibrosis." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17744.

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The thesis spans the spectrum of causative and therapeutic aspects of chronic kidney disease (CKD), which is a significant and growing health burden. An adverse in utero environment is increasingly recognised to predispose to chronic diseases in adulthood. Maternal smoking remains the most common modifiable adverse in-utero exposure leading to low birth weight, which is strongly associated with CKD in later life. In order to investigate underlying mechanisms for such susceptibility, a mouse model of maternal smoke exposure was used and the offspring examined at different developmental mileston

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Souza, Maysa Lucena de. "Expressão intra-renal dos RNA mensageiros de proteínas associadas ao podócito e de fatores pro fibróticos em glomerulopatias primárias e secundárias." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/139755.

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Introdução: A podocitopenia e a podocitúria são marcadores de injúria glomerular em podocitopatias (POD) e glomerulonefrites proliferativas (GNsP), e mesmo em fases iniciais destas doenças mecanismos pró-fibróticos indutores de glomeruloesclerose e fibrose renal progressiva estão ativados. Objetivo: Avaliar pacientes portadores de glomerulopatias biopsiados em diferentes tempos de evolução clínica, correlacionando lesões morfológicas dos compartimentos glomerular e túbulo-intersticial com a expressão dos RNAm de proteínas associadas ao podócito e de fatores pró-fibróticos no tecido renal. Mate

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Goto, Yasufumi. "Studies on the molecular pathogenesis mechanism for renal fibrosis in hereditary nephrotic mouse." Kyoto University, 2006. http://hdl.handle.net/2433/144093.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第12356号<br>農博第1537号<br>新制||農||923(附属図書館)<br>学位論文||H18||N4114(農学部図書室)<br>24192<br>UT51-2006-J348<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授久米新一, 教授矢野秀雄, 教授今井裕<br>学位規則第4条第1項該当

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Yang, Fuye. "Mechanisms of angiotensin II-induced renal fibrosis role of TGF-?SMAD signaling pathway /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841641.

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Fretellier, Nathalie. "Rôle des complexes de gadolinium dans le mécanisme de la fibrose systémique néphrogénique." Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00843108.

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La fibrose systémique néphrogénique (FSN) est une maladie rare et relativement récente, observée uniquement chez des patients souffrant d'insuffisance rénale sévère ou terminale. Elle est liée à l'administration d'une certaine catégorie de complexes de gadolinium (CG), les CGs thermodynamiquement moins stables, utilisés comme produits de contraste pour l'imagerie par résonance magnétique. L'hypothèse mécanistique la plus couramment citée concerne les effets profibrosants du Gd3+ " libre " après dissociation in vivo des CGs les moins stables mais il n'en existe pas de démonstration formelle. La

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Haller, Steven T. "Marinobufagenin Induced Uremic Cardiomyopathy: The Role of Passive Immunization, Rapamycin, and CD40 Signaling in The Generation of Renal Fibrosis." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1339092544.

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Semedo, Patricia [UNIFESP]. "O papel das células-tronco mesenquimais em modelos experimentais de doença renal aguda e crônica." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9858.

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Made available in DSpace on 2015-07-22T20:50:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-05-27<br>Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP<br>Desde a década de 70 até o presente momento, o conhecimento sobre células-tronco (CTs) vêm crescendo exponencialmente. Dentre as CTs, interesse crescimento se dá no campo das células-tronco adultas, com especial atenção para as CTs da medula óssea, as células-tronco mesenquimais (CTMs). Muito têm se descoberto sobre o potencial terapêutico das CTMs para diversas patologias, devido a seu grande potencial em

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Yang, Fuye, and 扬付叶. "Mechanisms of angiotensin II-induced renal fibrosis: role of TGF-{221}/SMAD signaling pathway." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42841641.

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