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Littérature scientifique sur le sujet « Functional delivery »

Auteur : Grafiati

Publié le 29 mars 2025

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "Functional delivery"

Kim, Raeyeong, and Jong Hyun Kim. "Engineered Extracellular Vesicles with Compound-Induced Cargo Delivery to Solid Tumors." International Journal of Molecular Sciences 24, no. 11 (2023): 9368. http://dx.doi.org/10.3390/ijms24119368.

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Efficient delivery of functional factors into target cells remains challenging. Although extracellular vesicles (EVs) are considered to be potential therapeutic delivery vehicles, a variety of efficient therapeutic delivery tools are still needed for cancer cells. Herein, we demonstrated a promising method to deliver EVs to refractory cancer cells via a small molecule-induced trafficking system. We generated an inducible interaction system between the FKBP12-rapamycin-binding protein (FRB) domain and FK506 binding protein (FKBP) to deliver specific cargo to EVs. CD9, an abundant protein in EVs

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Gibbons, Jeremy. "Free delivery (functional pearl)." ACM SIGPLAN Notices 51, no. 12 (2018): 45–50. http://dx.doi.org/10.1145/3241625.2976005.

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Nakazato, Yugo, and Joji M. Otaki. "Protein Delivery to Insect Epithelial Cells In Vivo: Potential Application to Functional Molecular Analysis of Proteins in Butterfly Wing Development." BioTech 12, no. 2 (2023): 28. http://dx.doi.org/10.3390/biotech12020028.

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Protein delivery to cells in vivo has great potential for the functional analysis of proteins in nonmodel organisms. In this study, using the butterfly wing system, we investigated a method of protein delivery to insect epithelial cells that allows for easy access, treatment, and observation in real time in vivo. Topical and systemic applications (called the sandwich and injection methods, respectively) were tested. In both methods, green/orange fluorescent proteins (GFP/OFP) were naturally incorporated into intracellular vesicles and occasionally into the cytosol from the apical surface witho

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Kanada, Masamitsu, Michael H. Bachmann, Jonathan W. Hardy, et al. "Differential fates of biomolecules delivered to target cells via extracellular vesicles." Proceedings of the National Academy of Sciences 112, no. 12 (2015): E1433—E1442. http://dx.doi.org/10.1073/pnas.1418401112.

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Extracellular vesicles (EVs), specifically exosomes and microvesicles (MVs), are presumed to play key roles in cell–cell communication via transfer of biomolecules between cells. The biogenesis of these two types of EVs differs as they originate from either the endosomal (exosomes) or plasma (MVs) membranes. To elucidate the primary means through which EVs mediate intercellular communication, we characterized their ability to encapsulate and deliver different types of macromolecules from transiently transfected cells. Both EV types encapsulated reporter proteins and mRNA but only MVs transferr

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Barthélémy, Philippe, and Michel Camplo. "Functional Amphiphiles for Gene Delivery." MRS Bulletin 30, no. 9 (2005): 647–53. http://dx.doi.org/10.1557/mrs2005.191.

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AbstractThe design of safe and efficient gene transfer vectors remains one of the key challenges in gene therapy. Despite their remarkable transfection efficiency, viral vectors suffer from known safety issues. Consequently, significant research activity has been undertaken to develop nonviral approaches to gene transfer during the last decade. Numerous academic and industrial research groups are investigating synthetic cationic vectors, such as cationic amphiphiles, with the objective of increasing the gene transfection activity. Within this area, the development of functional synthetic vecto

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Tai, Wanyi, and Xiaohu Gao. "Functional peptides for siRNA delivery." Advanced Drug Delivery Reviews 110-111 (February 2017): 157–68. http://dx.doi.org/10.1016/j.addr.2016.08.004.

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Sago, Cory D., Melissa P. Lokugamage, Kalina Paunovska, et al. "High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing." Proceedings of the National Academy of Sciences 115, no. 42 (2018): E9944—E9952. http://dx.doi.org/10.1073/pnas.1811276115.

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Dysfunctional endothelium causes more disease than any other cell type. Systemically administered RNA delivery to nonliver tissues remains challenging, in large part because there is no high-throughput method to identify nanoparticles that deliver functional mRNA to cells in vivo. Here we report a system capable of simultaneously quantifying how >100 lipid nanoparticles (LNPs) deliver mRNA that is translated into functional protein. Using this system (named FIND), we measured how >250 LNPs delivered mRNA to multiple cell types in vivo and identified 7C2 and 7C3, two LNPs that efficiently

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Stone, Shane, Tatjana Heinrich, Suzy Juraja та ін. "β-Lactamase Tools for Establishing Cell Internalization and Cytosolic Delivery of Cell Penetrating Peptides". Biomolecules 8, № 3 (2018): 51. http://dx.doi.org/10.3390/biom8030051.

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The ability of cell penetrating peptides (CPPs) to deliver biologically relevant cargos into cells is becoming more important as targets in the intracellular space continue to be explored. We have developed two assays based on CPP-dependent, intracellular delivery of TEM-1 β-lactamase enzyme, a functional biological molecule comparable in size to many protein therapeutics. The first assay focuses on the delivery of full-length β-lactamase to evaluate the internalization potential of a CPP sequence. The second assay uses a split-protein system where one component of β-lactamase is constitutivel

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Schwarz, Carsten, Claudio Procaccianti, Laura Costa, et al. "Differential Performance and Lung Deposition of Levofloxacin with Different Nebulisers Used in Cystic Fibrosis." International Journal of Molecular Sciences 23, no. 17 (2022): 9597. http://dx.doi.org/10.3390/ijms23179597.

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We compared the performance and levofloxacin (Quinsair) lung deposition of three nebulisers commonly used in CF (I-Neb Advance, eFlow rapid, and LC Plus) with the approved nebuliser Zirela. The delivered dose, delivery rate, and aerosol particle size distribution (APSD) for each device were determined using the methods described in the Pharmacopeia. High-resolution computed tomography scans obtained from seven adult patients with mild CF were used to generate computer-aided, three-dimensional models of their airway tree to assess lung deposition using functional respiratory imaging (FRI). The

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Arnold, Amy E., Laura J. Smith, Greg Beilhartz, et al. "Attenuated diphtheria toxin mediates siRNA delivery." Science Advances 6, no. 18 (2020): eaaz4848. http://dx.doi.org/10.1126/sciadv.aaz4848.

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Toxins efficiently deliver cargo to cells by binding to cell surface ligands, initiating endocytosis, and escaping the endolysosomal pathway into the cytoplasm. We took advantage of this delivery pathway by conjugating an attenuated diphtheria toxin to siRNA, thereby achieving gene downregulation in patient-derived glioblastoma cells. We delivered siRNA against integrin-β1 (ITGB1)—a gene that promotes invasion and metastasis—and siRNA against eukaryotic translation initiation factor 3 subunit b (eIF-3b)—a survival gene. We demonstrated mRNA downregulation of both genes and the corresponding fu

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Thèses sur le sujet "Functional delivery"

Alexander, Shirin. "Multi functional polymers for drug delivery." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566691.

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Amphiphilic block and graft copolymers have been studied because of the possibility of tailoring their complex and fascinating chemical properties. Potential applications include wetting agents, foaming agents, plastic modifiers as well as biomedical applications in drug delivery, owing to their biocompatible and low toxic nature. This thesis describes the study of a series of amphiphilic block copolymers, known as Pluronics, and their aqueous interaction with a hydrophobic drug, flurbiprofen. Synthesis and characterisation of novel graft copolymers with interesting associative behaviour that

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Siva, Sahithi Pokala. "Design and delivery : functional colour web pages." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343620.

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Zhang, Chengxiang. "Functional Conjugates for Drug and Gene Delivery." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu158703024326976.

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Kilsby, Samuel. "Functional polyesters for drug delivery and 3D printing." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/20177.

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Funtional εCL monomers have been successfully synthesised utilising a primary amine (protected as a CBZ or BOC carbamate) and also a protected ketone (using an acetal protecting group). Amine derivatives were synthesised from the commercially available trans-4-aminocyclohexanol. The acetal protected ketone was synthesised from the commercially available 1,4-cyclohexanedione monoethylene acetal. The subsequent exposure of these monomers to ring opening polymerisation conditions (using stannous octanoate) in the presence of εCL, yielded random copolymers with a functionalised polyester backbone.

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Bansode, Ratnadeep Vitthal. "Functional ionic liquids in crystal engineering and drug delivery." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14563.

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The objective of this research is to explore the use of ionic liquds in crystal engineering and drug delivery. Ionic liquids have a wide range of applications in pharmaceutical field due to their unique physicochemical propertie ssuch as chemical, thermal stability, low melting point, nonvolatility, nonflamability, low toxicity and recyclability which offer unique and interesting potential for pharmaceuitcal applications. Currently, many research groups are working on the development of ionic liquids to use in this field but there is need to develop systematic understanding about new technique

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Bansode, Ratnadeep V. "Functional ionic liquids in crystal engineering and drug delivery." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14563.

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Wright, Ruvimbo Pearl. "Soysomes and Other Functional Biomaterials from Sucrose Soyate Derivatives." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/29872.

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Biomaterials serve as interventional tools in medicine to treat, improve or replace diseased tissues, organs or function of the body. Although several polymeric biomaterials already exist, they often present challenges, at material level, such as non-biodegradability, degradation into acidic by-products or tissue incompatibility, or at functional level such as failure to sustain prolonged release of therapeutic payload for a desired period. Research has been focused on investigating new polymeric candidates to address these problems of current systems. The use of renewable resources to generat

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Haag, Shannon S. "Effects of response-independent stimulus delivery and functional communication training." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2613.

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Thesis (M.A.)--West Virginia University, 2002.<br>Title from document title page. Document formatted into pages; contains viii, 38 p. : ill. Includes abstract. Includes bibliographical references (p. 33-37).

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Probert, John Michael. "Functional nano-particles derived from dendrimer derivatisation and self-assembly." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266664.

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Li, Zhenqing. "Development of Multi-functional Stem Cell Delivery Systems for Cardiac Therapy." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337223886.

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Livres sur le sujet "Functional delivery"

Spizzirri, Umile, and Giuseppe Cirillo, eds. Functional Hydrogels in Drug Delivery. CRC Press, 2017. http://dx.doi.org/10.1201/9781315152271.

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K, Neustadt Gail, ed. Reimbursable geriatric service delivery: A functional maintenance therapy system. Aspen Publishers, 1992.

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Cardwell, Wayne. The functional reconfiguration of a financial services delivery network: Consumer activity based spatial interaction modelling applied to an alternative approach to delivery planning. CSCA, Ryerson Polytechnic University, 1997.

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Ziaee, Reza. Preparing for continuous quality improvement for healthcare: Sustainability through functional tree structures. CRC Press/Taylor & Francis Group, 2015.

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LeBov, Sloane Beverly, Harder Richard K, and Sloane Robert M, eds. Introduction to healthcare delivery organizations: Functions, and management. 4th ed. Health Administration Press, 1999.

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Wong, Yau-Chuen. Some topics in functional analysis and operator theory: Lectures delivered at The National Instructional Centre for Graduate Students in Mathematics at Zhongshan (Sun Yat-Sen) University, 1990-91. Science Press, 1993.

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W, Moran John, and Riley William, eds. Quality function deployment and lean-six sigma applications in public health. ASQ Quality Press, 2006.

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Raffel, Marshall W. The U.S. health system: Origins and functions. 3rd ed. Wiley, 1989.

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K, Raffel Norma, ed. The U.S. health system: Origins and functions. 4th ed. Delmar Publishers, 1994.

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Jorgensen, Huston Carol, ed. Leadership roles and management functions in nursing: Theory and application. 4th ed. Lippincott Williams & Wilkins, 2003.

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Chapitres de livres sur le sujet "Functional delivery"

Saeed, Muhammad Usama, Nazim Hussain, and Muhammad Bilal. "Biomaterials in Gene Delivery." In Functional Biomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7152-4_5.

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Saleem, Imran, Yousef Rasmi, Leyla Fath-Bayati, and Zohreh Arabpour. "Functional Nanomaterials." In Drug Delivery Using Nanomaterials. CRC Press, 2021. http://dx.doi.org/10.1201/9781003168584-6.

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Khatun, Sajmina, Sabeerabi Bonala, Sunil Venkanna Pogu, and Aravind Kumar Rengan. "Functional Biomaterials: Drug Delivery and Biomedical Applications Polymeric Micelle in Drug Delivery Applications." In Functional Biomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7152-4_1.

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Padua, Graciela. "Bicontinuous delivery systems." In Nanotechnology and Functional Foods. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118462157.ch15.

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Praveen, Arshiya, and Mohd Aqil. "Transdermal Delivery of Chitosan-Based Systems." In Functional Chitosan. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0263-7_3.

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Natesan, Subramanian, Venkateshwaran Krishnaswami, Saranya Thekkila Veedu, Dhilin Pathayappurakkal Mohanan, K. Ruckmani, and Rajaguru Palanichamy. "Chitosan-Based Ocular Drug Delivery Systems." In Functional Chitosan. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0263-7_4.

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Pellá, Michelly Cristina Galdioli, Hugo Henrique Carline de Lima, Andrelson Wellington Rinaldi, et al. "Chitosan-Based Hydrogels for Drug Delivery." In Functional Chitosan. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0263-7_6.

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Sharma, Divya, Sanjay Arora, Bruna dos Santos Rodrigues, Sushant Lakkadwala, Amrita Banerjee, and Jagdish Singh. "Chitosan-Based Systems for Gene Delivery." In Functional Chitosan. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0263-7_8.

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Rodríguez-Rodríguez, Rogelio, Hugo Espinosa-Andrews, and Zaira Yunuen García-Carvajal. "Stimuli-Responsive Hydrogels in Drug Delivery." In Functional Biomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7152-4_3.

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Bharti, Kanchan, and Brahmeshwar Mishra. "pH-Responsive Biomaterials in Drug Delivery." In Functional Biomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7152-4_2.

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Actes de conférences sur le sujet "Functional delivery"

Sathyakumar, Damodaran Chingleput. "Reliable delivery of critical & cross functional UX through universal renderer systems under tight SLA constraints." In 2024 4th International Symposium on Computer Technology and Information Science (ISCTIS). IEEE, 2024. http://dx.doi.org/10.1109/isctis63324.2024.10699208.

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Shirazi, Dorsa, and Dorcas Kaweesa. "Multi Modular-Rotorcraft: An Advanced Multi-Functional and Multi-Purpose Rotorcraft." In Vertical Flight Society 81st Annual Forum and Technology Display. The Vertical Flight Society, 2025. https://doi.org/10.4050/f-0081-2025-219.

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The NASA Revolutionary Vertical Lift Technology project supports advanced air mobility missions through various vertical take-off and landing related projects. These efforts expand rotorcraft technology to improve the quality of life and perform "public good" missions through numerous mission concepts. The work presented herein introduces Multi Modular-Rotorcraft (MMR) technology, which explores the multifunctionality of sub-vehicles to expand the number of simultaneous missions for a rotorcraft. MMR technology can advance aeronautics through inspired transformational innovations. In this pape

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Gibbons, Jeremy. "Free delivery (functional pearl)." In ICFP'16: ACM SIGPLAN International Conference on Functional Programming. ACM, 2016. http://dx.doi.org/10.1145/2976002.2976005.

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Ze-hong, Sun, and Zhao Guang-yuan. "Multi-functional Parcel Delivery Locker system." In 2015 International Conference on Computer and Computational Sciences (ICCCS). IEEE, 2015. http://dx.doi.org/10.1109/iccacs.2015.7361351.

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Shirmanova, Marina V., Maria M. Lukina, Diana V. Yuzhakova, et al. "Functional Imaging and Treatment of Tumors with New Fluorescent Proteins." In Optical Molecular Probes, Imaging and Drug Delivery. OSA, 2019. http://dx.doi.org/10.1364/omp.2019.ot1d.2.

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Papoutsoglou, George. "In vivo Estimation of Functional and Structural Characteristics in Epithelial Neoplasia." In Optical Molecular Probes, Imaging and Drug Delivery. OSA, 2011. http://dx.doi.org/10.1364/omp.2011.oma5.

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Alexaki, Konstantina, Maria-Eleni Kyriazi, Afaf H. El-Sagheer, Tom Brown, and Antonios G. Kanaras. "Engineering functional nanoparticles for delivery in cells." In Colloidal Nanoparticles for Biomedical Applications XV, edited by Marek Osiński and Antonios G. Kanaras. SPIE, 2020. http://dx.doi.org/10.1117/12.2538470.

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Blanco, Letia, Panos S. Shiakolas, Pranesh B. Aswath, et al. "A Thermoresponsive Hydrogel Based Controlled Drug Delivery Device." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-88564.

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Thermoresponsive hydrogels exhibit the unique property of volume change as a function of change in temperature as they transition between hydrophilic and hydrophobic states. These hydrogels can be loaded with drug/protein and serve as reservoirs for drug/protein delivery applications. A hydrogel based device for controlled drug delivery is designed with a number of subsystems that are interfaced with LabVIEW for development of a functional device. The device was designed using analytical and finite element analysis procedures and fabricated. In this manuscript, the device design will be review

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Deutsch, Riley J., Roujia Wang, Enakshi D. Sunassee, Megan C. Madonna, Brian T. Crouch, and Nimmi Ramanujam. "Development of a multi-scale platform to quantify metabolic heterogeneity in vivo." In Optical Molecular Probes, Imaging and Drug Delivery. Optica Publishing Group, 2023. http://dx.doi.org/10.1364/omp.2023.ow1e.3.

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We developed an approach to quantify intratumoral metabolic heterogeneity of in vivo tumor models by leveraging a computationally designed multi-scale microscope and a suite of exogenous fluorescent contrast agents to provide functional and structural information.

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Hoermann, Karl, Norbert Stasche, Antonio Baker-Schreyer, Matthias Christ, Paul Goedert, and Hans-Jochen Foth. "Carbon dioxide laser delivery systems in functional paranasal sinus surgery." In Europto Biomedical Optics '93, edited by Kazuhiko Atsumi, Cornelius Borst, Frank W. Cross, et al. SPIE, 1994. http://dx.doi.org/10.1117/12.169135.

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Rapports d'organisations sur le sujet "Functional delivery"

Truong, Kris, and Michell Dolfini-Reed. Behavioral Health Care Delivery Models and Examples: Contractual to Functional Integration. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada401079.

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Juco, Marianne, Ricxie Maddawin, and Rosario Manasan. An Assessment of the Local Government Units' Functional Assignments under a Decentralized Regime. Philippine Institute for Development Studies, 2024. https://doi.org/10.62986/dp2024.40.

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The Philippines embraced a devolution agenda in 1991, leading to the enactment of the Local Government Code (LGC). Despite over three decades of implementation, devolution has remained incomplete, resulting in blurred accountability between the national government and local government units (LGUs) and inefficient delivery of basic devolved services. In March 2023, President Ferdinand Marcos Jr. ordered a review of the functions, services, and facilities that will be fully devolved to local governments. As part of this review, the study assesses LGU functional assignments across three critical

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Mix, Scott R., Mark A. Rice, Charles M. Schmidt, et al. Universal Utility Data Exchange (UUDEX) Functional Design Requirements: Cybersecurity of Energy Delivery Systems Research and Development. Office of Scientific and Technical Information (OSTI), 2018. http://dx.doi.org/10.2172/1510730.

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DeSimone, Joseph, Jude Samulski, Jeffrey Frelinger, and Sergio Sheiko. Replicating Viral Particles and other Shape-controlled, Functional Particles for Targeted Delivery Applications Using Nano-molding Techniques. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada482673.

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Moon, Dr Myung Jae. Strategic approaches in rightsizing and restructuring initiatives in the public sector. Asian Productivity Organization, 2025. https://doi.org/10.61145/khyc7992.

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This study examines the evolution from New Public Management's downsizing approaches to contemporary rightsizing strategies in public sector reform. Analyzing seven APO member cases, the research identifies how governments balance efficiency gains with institutional capacity preservation. Findings reveal that successful restructuring requires strategic alignment of government size, functional scope, and administrative capabilities. The proposed framework for rightsizing maintains core public service delivery while incorporating digital transformation and performance management. These insights

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Mawassi, Munir, Baozhong Meng, and Lorne Stobbs. Development of Virus Induced Gene Silencing Tools for Functional Genomics in Grapevine. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7613887.bard.

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Grapevine is perhaps the most widely grown fruit crop. To understand the genetic make-up so as to improve the yield and quality of grapes and grape products, researchers in Europe have recently sequenced the genomes of Pinot noir and its inbred. As expected, function of many grape genes is unknown. Functional genomics studies have become the major focus of grape researchers and breeders. Current genetic approaches for gene function studies include mutagenesis, crossing and genetic transformation. However, these approaches are difficult to apply to grapes and takes long periods of time to accom

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Gutierrez-Arias, Ruvistay, Camila González-Mondaca, Vinka Marinkovic-Riffo, Marietta Ortiz-Puebla, Fernanda Paillán-Reyes, and Pamela Seron. Considerations for ensuring safety during telerehabilitation of people with stroke. A protocol for a scoping review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.9.0104.

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Review question / Objective: To summarise measures or aspects targeted at reducing the incidence of adverse events during the delivery of exercise interventions through telerehabilitation in patients after stroke. Background: The sequelae in people with stroke are diverse. Regarding physical function post-stroke, functional impairment of the upper and lower extremities is common, which may be due to weakness or paralysis, sensory loss, spasticity, and abnormal motor synergies. In addition, a near 15% prevalence of sarcopenia has been found in people with stroke. Gait impairment has been observ

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Diprose, Rachael, Primatia Wulandari, Elena Williams, and Levriana Yustriani. Bureaucratic Reform in Indonesia: Policy Analyst Experiences. University of Melbourne with Knowledge Sector Initiative (KSI), 2020. http://dx.doi.org/10.46580/124364.

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In recent years, Indonesia has introduced reforms to its bureaucracy in response to critiques of the quality of government policy design and delivery. The Grand Design of Bureaucratic Reform strategy seeks to reduce the number of civil servants employed in administrative or managerial positions (structural appointments) in favour of skills-based recruitment into ‘functional’ positions. Specifically, the introduction of the ‘policy analyst’ position as a functional position in the civil service has sought to improve evidence-based policy making and the quality of policy outcomes, by incorporati

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Hariharan, Anand, and Masatake (Masa) Yamamichi. Basic Tool Kit for Cybersecurity in Education Management Information Systems. Asian Development Bank, 2024. http://dx.doi.org/10.22617/wps240301-2.

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The increased reliance on online schooling modalities calls for provision of sufficient security in education management information systems (EMIS). Addressing cybersecurity-related issues is imperative for continuity of education service delivery and resilience of education systems. In case of any cybersecurity threat materializing, an EMIS must recover and be functional within an acceptable period and level of data loss. This tool kit provides guidance for decision-makers and practitioners on how to formulate strategies and implement cybersecurity measures in an EMIS, what cybersecurity issu

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Pak, Kimchoeun. Fiscal Decentralisation in Cambodia: A Review of Progress and Challenges. Cambodia Development Resource Institute, 2011. https://doi.org/10.64202/wp.50.201105.

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To achieve democratic development, Cambodia’s next step towards fiscal decentralisation will focus on both institutional and service delivery reform at district level so as to strengthen the capacity of the sub-national administration and better link it to sectoral service delivery. To move forwards, fiscal decentralisation needs to be comprehensive and well coordinated with other cross-cutting reforms, especially the Public Financial Management Reform Programme, and sectoral reforms. This does not mean that everything has to be done at the same time, for doing so would overwhelm existing capa

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