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Littérature scientifique sur le sujet « Gastroprotective agents »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "Gastroprotective agents"

Nagy, Lajos, Romeo E. Morales, Martin Beinborn, Peter Vattay, and Sandor Szabo. "Investigation of gastroprotective compounds at subcellular level in isolated gastric mucosal cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 279, no. 6 (2000): G1201—G1208. http://dx.doi.org/10.1152/ajpgi.2000.279.6.g1201.

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We tested the hypothesis that recognized gastroprotective agents exert direct protection against ethanol-induced injury in isolated rat gastric mucosal cells in vitro. If protection exists, we also wanted to identify subcellular targets in the reversible and/or irreversible stages of cell injury. Ethanol-induced cell injury was quantified by measuring plasma membrane leakage (trypan blue exclusion and lactate dehydrogenase release), mitochondrial integrity (succinic dehydrogenase), and nuclear damage (ethidium bromide-DNA fluorescence). Initial cell viability and responsiveness were estimated

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Jones, Rachel. "Gastroprotective agents are underprescribed among NSAID users." Nature Reviews Gastroenterology & Hepatology 7, no. 7 (2010): 360. http://dx.doi.org/10.1038/nrgastro.2010.94.

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Ardiles, Alejandro, Ruth Barrientos, Mario Simirgiotis, Jorge Bórquez, Beatriz Sepúlveda, and Carlos Areche. "Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert." Molecules 23, no. 9 (2018): 2361. http://dx.doi.org/10.3390/molecules23092361.

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Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytre

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Mandel, K. G., T. A. Bertram, M. K. Eichhold, S. C. Pepple, and M. J. Doyle. "Fatty Acid-mediated Gastroprotection Does Not Correlate with Prostaglandin Elevation in Rats Exposed to Various Chemical Insults." Veterinary Pathology 31, no. 6 (1994): 679–88. http://dx.doi.org/10.1177/030098589403100608.

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This study involved a comparison of activity of several long-chain fatty acids (arachidonic acid, dihomo-[γ]-linolenic acid, linoleic acid, and oleic acid) for protection against gastric mucosal damage elicited by taurocholic acid, acidified aspirin, and ethanol in rats. Each damaging agent induced gastric mucosal lesions in the corpus. Mucosal damage was induced by all agents, and all fatty acids protected the gastric mucosa; however, ethanol and arachidonic acid were the most potent damaging and protecting agents, respectively. Maximally protective doses for prevention of taurocholic acid-in

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Slomiany, B. L., V. L. N. Murty, J. Piotrowski, and A. Slomiany. "Gastroprotective agents in mucosal defense against Helicobacter pylori." General Pharmacology: The Vascular System 25, no. 5 (1994): 833–41. http://dx.doi.org/10.1016/0306-3623(94)90084-1.

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Tundis, Rosa, Monica R. Loizzo, Marco Bonesi, et al. "Natural Products as Gastroprotective and Antiulcer Agents: Recent Developments." Natural Product Communications 3, no. 12 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301234.

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Peptic ulcer, one of the most common gastrointestinal diseases, is a chronic inflammatory disease characterized by ulceration in the regions of the upper gastrointestinal tract where parietal cells are found and where they secrete hydrochloric acid and pepsin. The anatomical sites where ulcer occurs commonly are stomach and duodenum, causing gastric and duodenal ulcer, respectively. Physiopathology of ulcer is due to an imbalance between aggressive factors, such as acid, pepsin, Helicobacter pylori and non-steroidal anti-inflammatory agents, and local mucosal defensive factors, such as mucus b

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PUIA, Aida, Diana SCHLANGER, and Ion C. PUIA. "The role of medicinal mushrooms as gastroprotective agents: A short narrative review." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 51, no. 4 (2023): 13532. http://dx.doi.org/10.15835/nbha51413532.

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This review examines the possible clinical uses of extracts from mushrooms with medicinal properties, particularly their role as gastroprotective agents. After conducting a thorough examination of the literature, we identified and chose publications that presented six distinct types of mushroom extracts. These extracts have been experimentally demonstrated to have gastroprotective effects in animal models. Animals like rats or mice were used as subjects in experimental models to generate stomach ulcers through various approaches, such as chemical induction or inducing stress. Studies have show

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Majeed, Wafa, Tanweer Khaliq, Bilal Aslam, Junaid Ali Khan, and Asra Iftikhar. "Medicinal plants with gastroprotective potential." Bangladesh Journal of Pharmacology 10, no. 3 (2015): 588. http://dx.doi.org/10.3329/bjp.v10i3.23578.

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<p class="Abstract">Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants

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Kudryavtsev, Konstantin V., Anna O. Markevich, Oleksandr V. Virchenko, et al. "Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile." Scientific World Journal 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/217039.

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This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical methods, and evaluatedin vivoat water immersion restraint conditions. The levels of lipid peroxidation products and activities of antioxidative system enzymes were measured in gastric mucosa and correlated with the observed gastroprotective activity of the active compounds. Prophylactic single-dose 1

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Cucala, M., P. Bauerfeind, C. Emde, J. J. Gonvers, H. R. Koelz, and A. L. Blum. "Is it Wise to Prescribe NSAIDs with Modern Gastroprotective Agents?" Scandinavian Journal of Rheumatology 16, sup65 (1987): 141–54. http://dx.doi.org/10.3109/03009748709102193.

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Chapitres de livres sur le sujet "Gastroprotective agents"

Alves Araujo de Lima, Cirlane, Robson Silva de Lima, Jesica Batista de Souza, et al. "Gastroprotective Mechanisms." In Peptic Ulcer Disease [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.101631.

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Gastric ulcer (GU), a common type of peptic ulcer, results from an imbalance in the action of protective and aggressive agents. Gastroprotective mechanisms are mucus layer, gastric epithelium, gastric blood flow, gastric neurons, mucosal repair capacity, and immune system. Thus, the aim of this chapter was to provide an update on gastroprotective mechanisms. It was carried out through searches in PubMed covering the years 2016–2021 using several keywords. This survey resulted in 428 articles, of which 110 were cited in this chapter. It was reviewed the status of gastroprotective mechanisms and

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Mahato, Harekrishna, and Brajesh Kumar. "Medicinal Uses with Immense Economic Potential and Nutritional Properties of Aegle marmelos: A Concise Review." In Biocomposites. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102876.

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Aegle marmelos is the only member of the monotype genus Aegle and belongs to the Rutaceae family, the citrus fruits family. This review shows the economically feasible pharmacological applications and the nutritional properties of A. marmelos. Each part of the A. marmelos/Bael tree such as root, bark, leaf, flower, fruit, and seed has therapeutic significance in Ayurvedic systems as well as other traditional medicines. In bael fruit, there are various valuable bioactive compounds that have remarkable nutritional and medicinal properties. The isolated components belong to alkaloids, terpenoids,

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Michelotti, Erica, Paul M. Ridker, and Raffaele De Caterina. "Antithrombotic strategies in primary cardiovascular prevention." In The ESC Textbook of Thrombosis, edited by Raffaele De Caterina, David J. Moliterno, and Steen Dalby Kristensen. Oxford University PressOxford, 2023. http://dx.doi.org/10.1093/med/9780192869227.003.0014.

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Abstract Antithrombotic strategies in primary cardiovascular prevention essentially revolve around the use of aspirin. This chapter provides an update and guidance for the use of aspirin in patients without previous clinical evidence of vascular disease. In contrast to secondary prevention, aspirin in primary prevention is widely debated in part because early trials predated the statin era. furthermore, because prevention of cardiovascular outcomes demonstrated in several trials was counterbalanced by increased risk for bleeding, a net clinical benefit has not clearly been shown in pooled esti

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Yashavanth, Holalu Shivashankaregowda, Raghavendra Haniadka, Suresh Rao, et al. "Turmeric and Its Principal Polyphenol Curcumin as a Nontoxic Gastroprotective Agent: Recent Update." In Polyphenols: Prevention and Treatment of Human Disease. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-813008-7.00027-8.

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Hegde, K., R. Haniadka, A. Alva, M. M. Periera-Colaco, and M. S. Baliga. "Turmeric (Curcuma longa L.) the Golden Curry Spice as a Nontoxic Gastroprotective Agent." In Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-397154-8.00040-3.

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Actes de conférences sur le sujet "Gastroprotective agents"

Caputi, AP, SX Kong, P. Mavros, E. Ricci, and A. Russo. "SAT0244 Concomitant use of gastroprotective agents among users of nonsteroidal antiinflammatory drugs in italy." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.880.

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