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Articles de revues sur le sujet « GE11 »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Du, Longhai, Yanlong Xu, Binxu Han, et al. "EGFR-targeting peptide conjugated polymer–lipid hybrid nanoparticles for delivery of salinomycin to osteosarcoma." Journal of Cancer Research and Therapeutics 19, no. 6 (2023): 1544–51. http://dx.doi.org/10.4103/jcrt.jcrt_2503_22.

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Context: Salinomycin (SAL) is a chemotherapeutic drug with anti-osteosarcoma efficacy, but its hydrophobic properties have hindered its application. Nanoparticles have been widely used as drug carriers to improve the solubility of hydrophobic drugs. The dodecapeptide GE11 has been shown to have great binding affinity to the epidermal growth factor receptor (EGFR), which is highly overexpressed in osteosarcoma. Materials and Methods: We designed novel SAL-loaded GE11-conjugated polymer–lipid hybrid nanoparticles (GE11-NPs-SAL) to target osteosarcoma. The characterization and antitumor activity

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Chiesa, Enrica, Silvia Pisani, Barbara Colzani, et al. "Intra-Articular Formulation of GE11-PLGA Conjugate-Based NPs for Dexamethasone Selective Targeting—In Vitro Evaluation." International Journal of Molecular Sciences 19, no. 8 (2018): 2304. http://dx.doi.org/10.3390/ijms19082304.

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Selectively targeted nanoscale drug delivery systems have recently emerged as promising intravenously therapeutic option for most chronic joint diseases. Here, a newly synthetized dodecapeptide (GE11)-polylactide-co-glycolide (PLGA)-based conjugate was used to prepare smart nanoparticles (NPs) intended for intra-articular administration and for selectively targeting Epidermal Growth Factor Receptor (EGFR). GE11-PLGA conjugate-based NPs are specifically uptaken by EGFR-overexpressed fibroblast; such as synoviocytes; which are the primarily cellular component involved in the development of destr

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Gaurav, Isha, Abhimanyu Thakur, Kui Zhang, et al. "Peptide-Conjugated Vascular Endothelial Extracellular Vesicles Encapsulating Vinorelbine for Lung Cancer Targeted Therapeutics." Nanomaterials 14, no. 20 (2024): 1669. http://dx.doi.org/10.3390/nano14201669.

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Lung cancer is one of the major cancer types and poses challenges in its treatment, including lack of specificity and harm to healthy cells. Nanoparticle-based drug delivery systems (NDDSs) show promise in overcoming these challenges. While conventional NDDSs have drawbacks, such as immune response and capture by the reticuloendothelial system (RES), extracellular vesicles (EVs) present a potential solution. EVs, which are naturally released from cells, can evade the RES without surface modification and with minimal toxicity to healthy cells. This makes them a promising candidate for developin

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Huang, Xueqin, Lingzhi Chen, Yuping Zhang, et al. "GE11 Peptide Conjugated Liposomes for EGFR-Targeted and Chemophotothermal Combined Anticancer Therapy." Bioinorganic Chemistry and Applications 2021 (March 31, 2021): 1–15. http://dx.doi.org/10.1155/2021/5534870.

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How to actively target tumor sites manipulating the controllable release of the encapsulated anticancer drugs and photosensitizers for synergistic anticancer therapy remains a big challenge. In this study, a cancer cell-targeted, near-infrared (NIR) light-triggered and anticancer drug loaded liposome system (LPs) was developed for synergistic cancer therapy. Photosensitizer indocyanine green (ICG) and chemotherapy drug Curcumin (CUR) were coencapsulated into the liposomes, followed by the surface conjugation of GE11 peptide for epidermal growth factor receptor (EGFR) targeting on the cancer ce

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Li, Kaichun, Liying Pang, Xiaorong Pan, et al. "GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells." Technology in Cancer Research & Treatment 20 (January 1, 2021): 153303382110049. http://dx.doi.org/10.1177/15330338211004954.

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Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy. The occurrence of various side effect of Sal greatly limits its application. The epidermal growth factor receptor (EGFR) family is a family of receptors highly expressed in most breast cancer cells. GE11 is a dodecapeptide which shows excellent EGFR affinity. A series of nanoparticles derivatives with GE11 peptide conjugated PLGA/TPGS were synthesized. Nanoprecipitation method was used to prepare the Sal loaded nanoparticles at the optimized concentration. The characterization, targeting e

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Gimond, Clotilde, Arjan van der Flier, Sanne van Delft та ін. "Induction of Cell Scattering by Expression of β1 Integrins in β1-Deficient Epithelial Cells Requires Activation of Members of the Rho Family of Gtpases and Downregulation of Cadherin and Catenin Function". Journal of Cell Biology 147, № 6 (1999): 1325–40. http://dx.doi.org/10.1083/jcb.147.6.1325.

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Adhesion receptors, which connect cells to each other and to the surrounding extracellular matrix (ECM), play a crucial role in the control of tissue structure and of morphogenesis. In this work, we have studied how intercellular adhesion molecules and β1 integrins influence each other using two different β1-null cell lines, epithelial GE11 and fibroblast-like GD25 cells. Expression of β1A or the cytoplasmic splice variant β1D, induced the disruption of intercellular adherens junctions and cell scattering in both GE11 and GD25 cells. In GE11 cells, the morphological change correlated with the

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Gé, Lorraine Gaenaelle, Mathias Bogetoft Danielsen, Aaraby Yoheswaran Nielsen, et al. "Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics." Molecules 30, no. 2 (2025): 212. https://doi.org/10.3390/molecules30020212.

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The overexpression of the epidermal growth factor receptor (EGFR) in certain types of prostate cancers and glioblastoma makes it a promising target for targeted radioligand therapy. In this context, pairing an EGFR-targeting peptide with the emerging theranostic pair comprising the Auger electron emitter cobalt-58m (58mCo) and the Positron Emission Tomography-isotope cobalt-55 (55Co) would be of great interest for creating novel radiopharmaceuticals for prostate cancer and glioblastoma theranostics. In this study, GE11 (YHWYGYTPQNVI) was investigated for its EGFR-targeting potential when conju

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Yang, Chengcheng, Xuan Mi, Huilan Su, et al. "GE11-PDA-Pt@USPIOs nano-formulation for relief of tumor hypoxia and MRI/PAI-guided tumor radio-chemotherapy." Biomaterials Science 7, no. 5 (2019): 2076–90. http://dx.doi.org/10.1039/c8bm01492b.

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Lee, Duhwan, Yeong Mi Lee, Jihoon Kim, Myung Kyu Lee, and Won Jong Kim. "Enhanced tumor-targeted gene delivery by bioreducible polyethylenimine tethering EGFR divalent ligands." Biomaterials Science 3, no. 7 (2015): 1096–104. http://dx.doi.org/10.1039/c5bm00004a.

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Gaugaz, Fabienne, Andrea Chicca, Mariano Redondo-Horcajo, Isabel Barasoain, J. Díaz, and Karl-Heinz Altmann. "Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate." International Journal of Molecular Sciences 20, no. 5 (2019): 1113. http://dx.doi.org/10.3390/ijms20051113.

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A new simplified, epoxide-free epothilone analog was prepared incorporating an N-(2-hydroxyethyl)-benzimidazole side chain, which binds to microtubules with high affinity and inhibits cancer cell growth in vitro with nM potency. Building on this scaffold, a disulfide-linked conjugate with the purported EGFR-binding (EGFR, epidermal growth factor receptor) peptide GE11 was then prepared. The conjugate retained significant microtubule-binding affinity, in spite of the size of the peptide attached to the benzimidazole side chain. The antiproliferative activity of the conjugate was significantly l

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Abourbeh, Galith, Alexei Shir, Eyal Mishani, et al. "PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors." IUBMB Life 64, no. 4 (2012): 324–30. http://dx.doi.org/10.1002/iub.1002.

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Oertel, F., F. Starke, W. Sihver, J. Steinbach, and H. J. Pietzsch. "In vitro evaluation of 64Cu-labeled GE11-conjugates." Nuclear Medicine and Biology 41, no. 7 (2014): 634–35. http://dx.doi.org/10.1016/j.nucmedbio.2014.05.035.

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Judmann, Benedikt, Björn Wängler, Ralf Schirrmacher, Gert Fricker, and Carmen Wängler. "Towards Radiolabeled EGFR-Specific Peptides: Alternatives to GE11." Pharmaceuticals 16, no. 2 (2023): 273. http://dx.doi.org/10.3390/ph16020273.

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The human epidermal growth factor receptor (EGFR) is closely related to several cancer-promoting processes and overexpressed on a variety of tumor types, rendering it an important target structure for the imaging and therapy of several malignancies. To date, approaches to develop peptidic radioligands able to specifically address and visualize EGFR-positive tumors have been of limited success. Most of the attempts were based on the lead GE11, as this peptide was previously described to be a highly potent EGFR-specific agent. However, since it has recently been shown that GE11 exhibits an insuf

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Luo, H. B., X. B. Li, Q. E. Zhang, M. D. Chen, and Y. K. Cheng. "A density functional theory study of germanium Ge11 clusters." Journal of Molecular Structure: THEOCHEM 674, no. 1-3 (2004): 83–86. http://dx.doi.org/10.1016/j.theochem.2004.01.010.

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Soleymani Abyaneh, Hoda, Amir Soleimani, Mohammad Vakili, et al. "Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance." Pharmaceutics 10, no. 4 (2018): 196. http://dx.doi.org/10.3390/pharmaceutics10040196.

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Hypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two strategies for the modulation of HICR against cisplatin micelles: a) the development of actively targeted micelles; and b) combination therapy with modulators of HICR in MDA-MB-231 cells. Actively targeted cisplatin micelles were prepared through surface modification of acetal-poly(ethylene oxide)-poly(

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Verwilligen, Piet. "GEM detectors for the CMS endcap muon system: status of three new detector stations." Journal of Instrumentation 18, no. 07 (2023): C07006. http://dx.doi.org/10.1088/1748-0221/18/07/c07006.

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Abstract The High-Luminosity LHC (HL-LHC, or Phase-2 LHC) will deliver proton-proton collisions at 5–7.5 times the nominal LHC luminosity, with an expected number of 140–200 pp-interactions per bunch crossing (Pile-up or PU). To maintain the performance of muon triggering and reconstruction under high background, the forward part of the Muon Spectrometer of the CMS experiment will be upgraded with Gas Electron Multipliers (GEM) and improved Resistive Plate Chambers (iRPC) detectors [1,2]. A first GEM station (GE1/1) was installed during Long Shutdown 2 (LS2, 2019–2021), a 2nd station (GE2/1) o

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Quinn, Jeffrey A., C. Thomas Graeber, A. Raymond Frackelton, Minsoo Kim, Jean E. Schwarzbauer, and Edward J. Filardo. "Coordinate Regulation of Estrogen-Mediated Fibronectin Matrix Assembly and Epidermal Growth Factor Receptor Transactivation by the G Protein-Coupled Receptor, GPR30." Molecular Endocrinology 23, no. 7 (2009): 1052–64. http://dx.doi.org/10.1210/me.2008-0262.

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Abstract Estrogen promotes changes in cytoskeletal architecture not easily attributed to the biological action of estrogen receptors, ERα and ERβ. The Gs protein-coupled transmembrane receptor, GPR30, is linked to specific estrogen binding and rapid estrogen-mediated release of heparin-bound epidermal growth factor. Using marker rescue and dominant interfering mutant strategies, we show that estrogen action via GPR30 promotes fibronectin (FN) matrix assembly by human breast cancer cells. Stimulation with 17β-estradiol or the ER antagonist, ICI 182, 780, results in the recruitment of FN-engaged

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Biscaglia, Francesca, Senthilkumar Rajendran, Paolo Conflitti, et al. "Enhanced EGFR Targeting Activity of Plasmonic Nanostructures with Engineered GE11 Peptide." Advanced Healthcare Materials 6, no. 23 (2017): 1700596. http://dx.doi.org/10.1002/adhm.201700596.

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Abdulmalek, Shaymaa, Nouf Mostafa, Marwa Gomaa, Mohamed El‑Kersh, Ayman I. Elkady, and Mahmoud Balbaa. "Bee venom-loaded EGFR-targeting peptide-coupled chitosan nanoparticles for effective therapy of hepatocellular carcinoma by inhibiting EGFR-mediated MEK/ERK pathway." PLOS ONE 17, no. 8 (2022): e0272776. http://dx.doi.org/10.1371/journal.pone.0272776.

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Hepatocellular carcinoma (HCC) is one of the world’s most risky diseases due to the lack of clear and cost-effective therapeutic targets. Currently, the toxicity of conventional chemotherapeutic medications and the development of multidrug resistance is driving research into targeted therapies. The nano-biomedical field’s potential for developing an effective therapeutic nano-sized drug delivery system is viewed as a significant pharmaceutical trend for the encapsulation and release of numerous anticancer therapies. In this regard, current research is centered on the creation of biodegradable

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Jiao, Honglei, Xinming Zhao, Jingya Han, Jingmian Zhang, and Jianfang Wang. "Synthesis of a novel 99mTc labeled GE11 peptide for EGFR SPECT imaging." International Journal of Radiation Biology 96, no. 11 (2020): 1443–51. http://dx.doi.org/10.1080/09553002.2020.1811419.

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Grataitong, Khwanthana, Wattana Weerachatyanukul, Krittalak Chakrabandhu, and Anne-Odile Hueber. "Modified MrNV viral capsids with GE11 peptide for binding colorectal cancer cells." FASEB Journal 34, S1 (2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.09231.

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Dissoki, Samar, Aviv Hagooly, Smadar Elmachily, and Eyal Mishani. "Labeling approaches for the GE11 peptide, an epidermal growth factor receptor biomarker." Journal of Labelled Compounds and Radiopharmaceuticals 54, no. 11 (2011): 693–701. http://dx.doi.org/10.1002/jlcr.1910.

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Zain, Mohd Izani Mohd, and Mohd Daud Mat Din. "Democratic Dilemma of Malay Islamic Party: PAS, Coalition Pattern, and Rising Social Issues." Studia Islamika 29, no. 1 (2022): 83–109. http://dx.doi.org/10.36712/sdi.v29i1.16330.

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This article deliberates on how the Pan-Malaysian Islamic Party (PAS) embraces and weathers the challenges of democracy as a political culture beyond elections. The deliberation analyses the approach and behaviors of the party within a period of three general elections (GE), namely the GE12 in 2008, GE13 in 2013, and GE14 in 2018. Through qualitative approach and in-depth interviews with key PAS leaders, this article discusses PAS participation with the Pakatan Rakyat (PR), Muafakat Nasional (MN), and Perikatan Nasional (PN), which demonstrated the PAS’s unchartered undertaking to accept democ

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Nadzri, Muhamad M. N. "The 14th General Election, the Fall of Barisan Nasional, and Political Development in Malaysia, 1957-2018." Journal of Current Southeast Asian Affairs 37, no. 3 (2018): 139–71. http://dx.doi.org/10.1177/186810341803700307.

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The results of the recent 2018 general election (GE14) in Malaysia were exceptional. The ruling party – Barisan Nasional (BN) – was ousted from power after over six decades of authoritarian rule, by a new opposition coalition – the Pakatan Harapan (PH). In this historic election, BN lost all the federal states in Peninsular Malaysia except for the two less developed ones of Perlis and Pahang. BN was also defeated in Sabah for the second time since its dramatic recapture in 1995. However, these results are not as surprising if one looks at the outcome from its historical and developmental persp

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Liu, Zhuo-Yan, Guang-Hai Yan, Xiao-Yu Li, et al. "GE11 peptide modified CSO-SPION micelles for MRI diagnosis of targeted hepatic carcinoma." Biotechnology & Biotechnological Equipment 35, no. 1 (2021): 1574–86. http://dx.doi.org/10.1080/13102818.2021.1997154.

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Rahmanian, Najmeh, Seyed Jalal Hosseinimehr, Ali Khalaj, Zohreh Noaparast, Seyed Mohammad Abedi, and Omid Sabzevari. "99mTc labeled HYNIC-EDDA/tricine-GE11 peptide as a successful tumor targeting agent." Medicinal Chemistry Research 27, no. 3 (2017): 890–902. http://dx.doi.org/10.1007/s00044-017-2111-7.

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Bouhali, O., V. Bhatnagar, A. Castaneda, et al. "Radiation background estimation for the GE11 Triple-GEM detectors in the CMS endcap." Journal of Physics: Conference Series 2374, no. 1 (2022): 012161. http://dx.doi.org/10.1088/1742-6596/2374/1/012161.

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The Compact Muon Solenoid (CMS) is a general-purpose particle detector at the Large Hadron Collider (LHC) designed to study a wide range of particles produced in high energy collisions. The interaction of the beams with the pipe, shielding and detector supporting materials can produce neutrons, photons, electrons and positrons, forming a common background radiation field for CMS detector. A Monte-Carlo simulation is used to predict the background rate for a newly installed detector. In the forward region, the upgrade includes Gas Electron Multiplier (GEM) detectors called GE1/1. In this study,

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Hailing, Tang, Pan Yonghong, Zhang Yufeng, and Tang Haitao. "Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment." Journal of Controlled Release 349 (September 2022): 592–605. http://dx.doi.org/10.1016/j.jconrel.2022.07.018.

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T. DeJesus, Onofre. "Synthesis of [64Cu]Cu-NOTA-Bn-GE11 for PET Imaging of EGFR-Rich Tumors." Current Radiopharmaceuticalse 5, no. 1 (2012): 15–18. http://dx.doi.org/10.2174/1874471011205010015.

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Chen, Chien-Jen, Chen-Hsin Chan, Kun-Liang Lin, et al. "68Ga-labelled NOTA-RGD-GE11 peptide for dual integrin and EGFR-targeted tumour imaging." Nuclear Medicine and Biology 68-69 (January 2019): 22–30. http://dx.doi.org/10.1016/j.nucmedbio.2018.11.003.

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Tang, Hailing, Xiaojing Chen, Mengjie Rui, et al. "Effects of Surface Displayed Targeting Ligand GE11 on Liposome Distribution and Extravasation in Tumor." Molecular Pharmaceutics 11, no. 10 (2014): 3242–50. http://dx.doi.org/10.1021/mp5001718.

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Striese, Franziska, Wiebke Sihver, Feng Gao, et al. "Exploring pitfalls of 64Cu-labeled EGFR-targeting peptide GE11 as a potential PET tracer." Amino Acids 50, no. 10 (2018): 1415–31. http://dx.doi.org/10.1007/s00726-018-2616-5.

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King, R. Bruce. "Trivalent Polyhedra as Duals of Borane Deltahedra: From Molecular Endohedral Germanium Clusters to the Smallest Fullerenes." Molecules 28, no. 2 (2023): 496. http://dx.doi.org/10.3390/molecules28020496.

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The duals of the most spherical closo borane deltahedra having from 6 to 16 vertices form a series of homologous spherical trivalent polyhedra with even numbers of vertices from 8 to 28. This series of homologous polyhedra is found in endohedral clusters of the group 14 atoms such as the endohedral germanium cluster anions [M@Ge10]3– (M = Co, Fe) and [Ru@Ge12]3– The next members of this series have been predicted to be the lowest energy structures of the endohedral silicon clusters Cr@Si14 and M@Si16 (M = Zr, Hf). The largest members of this series correspond to the smallest fullerene polyhedr

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Lunsford, Dale L. "Exploring Students' Perceptions of the Web as an Information Source." Journal of Educational Technology Systems 27, no. 4 (1999): 337–47. http://dx.doi.org/10.2190/ge11-34cn-adlt-py3x.

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Adem, B., A. L. Teixeira, F. Dias, C. Ruivo, R. Medeiros, and S. A. Melo. "GE11 positive exosomes as a potential RNAi delivery system in clear cell Renal Cell Carcinoma." Porto Biomedical Journal 2, no. 5 (2017): 181. http://dx.doi.org/10.1016/j.pbj.2017.07.016.

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Koay, Hean Wei, and Salwa Mokhtar Khairiah. "The role of political marketing and its importance in Barisan Nasional at Malaysia general election." Technium Social Sciences Journal 29 (March 9, 2022): 548–60. http://dx.doi.org/10.47577/tssj.v29i1.6138.

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This study discusses the political marketing tools based on the research in Barisan Nasional (BN) at Malaysia general election. According to the Malaysian law, the date of the last election and subsequent election is to be held at 5-year intervals. Thus, after GE12 in 2008, GE13 was held in 2013. Since 1969 from Alliance coalition to 1973 BN coalition never lost a general election in parliamentary constituency. The political tsunami in GE12 BN won 140 seats in Dewan Rakyat out of 222 seats, opposition parties such as Pakatan Rakyat (PR) won 82 seats out of 222 Dewan Rakyat of seats in Malaysia

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Iijima, Junko, Yanyang Zhao, Tomoya Isaji, et al. "Cell-Cell Interaction-dependent Regulation ofN-Acetylglucosaminyltransferase III and the BisectedN-Glycans in GE11 Epithelial Cells." Journal of Biological Chemistry 281, no. 19 (2006): 13038–46. http://dx.doi.org/10.1074/jbc.m601961200.

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Xu, Qingsong, Chen Qu, Wenjing Wang, Jianguo Gu, Yuguang Du, and Linsheng Song. "SpecificN-glycan alterations are coupled in epithelial-mesenchymal transition induced by EGF in GE11 epithelial cells." Cell Biology International 41, no. 2 (2016): 124–33. http://dx.doi.org/10.1002/cbin.10707.

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Haddick, Lisa, Wei Zhang, Sören Reinhard, et al. "Particle-Size-Dependent Delivery of Antitumoral miRNA Using Targeted Mesoporous Silica Nanoparticles." Pharmaceutics 12, no. 6 (2020): 505. http://dx.doi.org/10.3390/pharmaceutics12060505.

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Multifunctional core-shell mesoporous silica nanoparticles (MSN) were tailored in size ranging from 60 to 160 nm as delivery agents for antitumoral microRNA (miRNA). The positively charged particle core with a pore diameter of about 5 nm and a stellate pore morphology allowed for an internal, protective adsorption of the fragile miRNA cargo. A negatively charged particle surface enabled the association of a deliberately designed block copolymer with the MSN shell by charge-matching, simultaneously acting as a capping as well as endosomal release agent. Furthermore, the copolymer was functional

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Xu, Wei-Wei, Da-yu Liu, Ying-chun Cao, and Xiang-yun Wang. "GE11 peptide-conjugated nanoliposomes to enhance the combinational therapeutic efficacy of docetaxel and siRNA in laryngeal cancers." International Journal of Nanomedicine Volume 12 (September 2017): 6461–70. http://dx.doi.org/10.2147/ijn.s129946.

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Zou, Yan, Yifeng Xia, Fenghua Meng, Jian Zhang, and Zhiyuan Zhong. "GE11-Directed Functional Polymersomal Doxorubicin as an Advanced Alternative to Clinical Liposomal Formulation for Ovarian Cancer Treatment." Molecular Pharmaceutics 15, no. 9 (2018): 3664–71. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00024.

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Hui, Hon Chung. "Were Foreign Exchange Markets Reacting Negatively to Political Events? The Case of Malaysia." South Asian Journal of Macroeconomics and Public Finance 10, no. 1 (2021): 105–29. http://dx.doi.org/10.1177/2277978721995649.

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This article explores the effects of political events on foreign exchange returns in Malaysia. We identify five political events in recent history, namely the 13th General Election (GE13), the imprisonment of a key opposition politician, the scandal from the 1MDB exposé, the appointment of a new Central Bank Governor and the 14th General Election (GE14). Using event studies, our findings show that the imprisonment of the opposition party leader triggered a favourable response from the foreign exchange market. However, market reactions to the 1MDB scandal were largely unfavourable. The GE13 tri

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Xin, Xiaofei, Virender Kumar, Feng Lin, et al. "Redox-responsive nanoplatform for codelivery of miR-519c and gemcitabine for pancreatic cancer therapy." Science Advances 6, no. 46 (2020): eabd6764. http://dx.doi.org/10.1126/sciadv.abd6764.

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Desmoplastic and hypoxic pancreatic cancer microenvironment induces aberrant expression of miRNAs and hypoxia-inducible factor-1α (HIF-1α) responsible for gemcitabine (GEM) resistance. We demonstrated that miR-519c was down-regulated in pancreatic cancer and transfection of miR-519c in GEM-resistant pancreatic cancer cells inhibited HIF-1α level under hypoxia. We synthesized redox-sensitive mPEG-co-P(Asp)-g-DC-g-S-S-GEM polymer, with GEM payload of 14% (w/w) and 90% GEM release upon incubation with l-glutathione. We synthesized mPEG-co-P(Asp)-g-TEPA-g-DC for complex formation with miRNA. Chemi

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Zhou, Cheng, Yifeng Xia, Yaohua Wei, et al. "GE11 peptide-installed chimaeric polymersomes tailor-made for high-efficiency EGFR-targeted protein therapy of orthotopic hepatocellular carcinoma." Acta Biomaterialia 113 (September 2020): 512–21. http://dx.doi.org/10.1016/j.actbio.2020.06.020.

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Hu, Danrong, Omar Mezghrani, Lei Zhang, Yi Chen, Xue Ke, and Tianyuan Ci. "GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy." International Journal of Nanomedicine Volume 11 (October 2016): 5125–47. http://dx.doi.org/10.2147/ijn.s113469.

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Yu, Hung-Man, Jyun-Hong Chen, Kun-Liang Lin, and Wuu-Jyh Lin. "Synthesis of68Ga-labeled NOTA-RGD-GE11 heterodimeric peptide for dual integrin and epidermal growth factor receptor-targeted tumor imaging." Journal of Labelled Compounds and Radiopharmaceuticals 58, no. 7 (2015): 299–303. http://dx.doi.org/10.1002/jlcr.3296.

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Li, Xueli, Kongzhen Hu, Wenfeng Liu, et al. "Synthesis and evaluation of [18F]FP-Lys-GE11 as a new radiolabeled peptide probe for epidermal growth factor receptor (EGFR) imaging." Nuclear Medicine and Biology 90-91 (November 2020): 84–92. http://dx.doi.org/10.1016/j.nucmedbio.2020.10.004.

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Paiva, Igor, Stephanie Mattingly, Melinda Wuest, et al. "Synthesis and Analysis of 64Cu-Labeled GE11-Modified Polymeric Micellar Nanoparticles for EGFR-Targeted Molecular Imaging in a Colorectal Cancer Model." Molecular Pharmaceutics 17, no. 5 (2020): 1470–81. http://dx.doi.org/10.1021/acs.molpharmaceut.9b01043.

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Lan, Qinghua, Shuanghu Wang, Zhouming Chen, et al. "Near-infrared-responsive GE11-CuS@Gal nanoparticles as an intelligent drug release system for targeting therapy against oral squamous cell carcinoma." International Journal of Pharmaceutics 649 (January 2024): 123667. http://dx.doi.org/10.1016/j.ijpharm.2023.123667.

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Korolev, Konstantin. "Morphophysiological test of Linum usitatissimum L. under conditions of different levels of chloride salinity." АгроЭкоИнфо 5, no. 65 (2024): 19. http://dx.doi.org/10.51419/202145519.

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Résumé :

The selection of resistant varieties under conditions of abiotic stress is an urgent direction in the adaptive selection of flax. The presented work reflects the assessment of the phenotypic variability of 12 hybrid combinations of flax-longshanks according to the morphophysiological parameters of seedlings under the action of chloride salinization of two levels (E1, E2). The genotypes of flax of the fourth (F4) – fifth (F5) generations were used as objects of research. Significant differences (p>0.05, p>0.01, p>0.001) between hybrid populations and media were revealed for most of the

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