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Littérature scientifique sur le sujet « Gene therapy »

Auteur : Grafiati
Publié le 4 juin 2021
Mis à jour le 25 juillet 2025

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Articles de revues sur le sujet "Gene therapy"

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Goyal, Anjana, Reena Doomra, Aayushi Garg, and Kruthiventi Hemalata. "CRISPR Gene Therapy in Dentistry." Asian Pacific Journal of Health Sciences 6, no. 2 (2019): 182–83. http://dx.doi.org/10.21276/apjhs.2019.6.2.26.

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Gawthorpe, Paula. "Gene Therapy Gene Therapy." Nursing Standard 17, no. 33 (2003): 29. http://dx.doi.org/10.7748/ns2003.04.17.33.29.b25.

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Kiran, M.Kulkarni Akshay M. Khot Sachin G.Lokapure Sagar Jadhav. "A BRIEF REVIEW ON GENE THERAPY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 3288–99. https://doi.org/10.5281/zenodo.1240458.

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Now days gene theraphy has interested area for reasearch as a purpose of medical condition or disease. Currently, gene therapy studies a broad range of potential therapeutic interventions, including the body's immune reaction to tumors, new blood vessels in the heart to alleviate heart attacks and to stop HIV-replication in patients with AIDS (Coleman et al., 2003). There is also renewed emphasis on the gene therapy of genetic diseases, such as hemophilia A and B, and cystic fibrosis. Human gene therapy experimentation raises many issues. In this review article, background of gene therapy,
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Ray Choudhury, Smita. "Human Gene Therapy: A Brief Review." International Journal of Science and Research (IJSR) 10, no. 6 (2021): 1133–35. https://doi.org/10.21275/sr21616183125.

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M. Gordon, Erlinda, Joshua R. Ravicz, Sant P. Chawla, et al. "CCNG1 oncogene: a novel biomarker for cancer therapy /gene therapy." Cancer Research and Cellular Therapeutics 5, no. 4 (2021): 01–09. http://dx.doi.org/10.31579/2640-1053/090.

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Background: Metastatic cancer is associated with an invariably fatal outcome. However, DeltaRex-G, a tumor-targeted retrovector encoding a gene-edited dominant-negative CCNG1 inhibitor gene, has induced long term (>10 years) survival of patients with chemo-resistant metastatic pancreatic adenocarcinoma, malignant peripheral nerve sheath tumor, osteosarcoma, B-cell lymphoma, and breast carcinoma. Objective: To evaluate the level of CCNG1 expression in tumors as a potential biomarker for CCNG1 (Cyclin G1-blocking) inhibitor therapy. Methods: CCNG1 RNA expression levels that were previously me
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Sose, Mr Aadesh S., and Mr Pramod M. Bhosale. "A Review on Gene Therapy for Cancer." International Journal of Research Publication and Reviews 4, no. 4 (2023): 3058–63. http://dx.doi.org/10.55248/gengpi.4.423.36713.

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Abhishek, Keskar. "Gene Therapy Review." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1704–15. https://doi.org/10.5281/zenodo.14249376.

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Gene therapy involves transferring genetic material into cells to treat disease. This review will discuss gene transfer methods and current and potential applications for craniofacial regeneration, focusing on future development and design. Non-viral gene delivery methods have limitations in gene transfer efficiency. However, they offer advantages such as safety, low immunogenicity, ease of manufacturing, and lack of DNA insert size restrictions. Viral vectors are natural tools for delivering genes. They can be tailored for targeting specific tissues, integrating into specific sites on chromos
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&NA;. "Gene therapy." Inpharma Weekly &NA;, no. 1161 (1998): 12. http://dx.doi.org/10.2165/00128413-199811610-00018.

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&NA;. "Gene therapy." Inpharma Weekly &NA;, no. 1184 (1999): 8. http://dx.doi.org/10.2165/00128413-199911840-00015.

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Peroutka, Christina, and Joann Bodurtha. "Gene Therapy." Pediatrics in Review 41, no. 11 (2020): 606–8. http://dx.doi.org/10.1542/pir.2019-0224.

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Thèses sur le sujet "Gene therapy"

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Vasanwala, Farha Huseini. "Gene manipulations for cancer gene therapy." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/289776.

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Tumor cells can be modified with cytokine genes such as the Interleukin-2 (IL-2) gene. The levels of IL-2 expressed are critical for successful treatment. We have tried to achieve higher levels of IL-2 than those currently available by conventional plasmids. Use of a transcriptional activator, e.g; the tat gene along with the HIV promoter driving the IL-2 gene, greatly increased IL-2 levels compared to widely used cytomegalovirus (CMV) driven plasmids. Control of the tat gene with an inducible promoter, i.e; the human HSP70B promoter, permitted control of gene expression. The inducibility of t
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Santos, João Miguel Almeida. "Gene therapy: development of a new nanocarrier system for mitochondrial gene therapy." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1627.

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Mitochondria are unique organelles that have their own genome, the mitochondrial DNA (mtDNA). Although quite small compared to nuclear DNA (nDNA), mutations in mtDNA are quite frequent due to the lack of protection and repair mechanisms. Per consequence, cytopathies and diseases are quite common and mostly associated with high energy demanding tissues such as muscles and the brain. Therefore, the development of a new and efficient mitochondrial gene therapy protocol is seen as a promising approach. During this MSc thesis we try to bring together a new nanocarrier system with the ability
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Nanda, Dharminderkoemar. "Gene therapy for gliomas." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13140.

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Hayes, E. A. L. "Anti-angiogenic gene therapy." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603877.

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The aim of this project was to assess a novel anti-angiogenic gene therapy in which a therapeutic gene is activated exclusively in proliferating endothelial cells using tissue-specific promoters and the Cre/IoxP recombination system. Adenoviruses and transgenic mice were generated in parallel to test individual components of the targeting system. One of the therapeutic effector strategies investigated was the herpes simplex virus-1 thymidine kinase (HSV-1TK)/ganciclovir (GCV)-mediated suicide system, which is reported to kill proliferating cells selectively. Administration of GCV to pTie2-TK t
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Bilsland, Alan. "Telomerase directed gene therapy." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272871.

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Katabi, Maha M. "Transcriptional targeting of suicide genes in cancer gene therapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0021/NQ55345.pdf.

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Morin, Kevin Wayne. "Scintigraphic imaging during gene therapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21605.pdf.

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Singwi, Sanjeev. "HIV gene therapy using nucleases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0001/MQ46100.pdf.

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Horst, Maarten ter. "Gene therapy of malignant gliomas." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/10864.

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Lau, Cara Jean. "Gene therapy for malignant gliomas." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18478.

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Gliomas are the most common primary brain tumours found in adults. The median survival of patients diagnosed with the most malignant form, glioblastoma multiforme (GBM), is 9-12 months and has changed little over the years despite advances in medical technology. Gene therapy may offer new solutions to treat this resistant disease. Hence, we tested three different gene therapy strategies. In our first study, we tested the efficacy of targeted therapy to correct common aberrations found in gliomas including amplification/mutation of receptor tyrosine kinases (RTK) and loss of PTEN, which result
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Livres sur le sujet "Gene therapy"

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Xanthopoulos, Kleanthis G., ed. Gene Therapy. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-72160-1.

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Blankenstein, Thomas, ed. Gene Therapy. Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-7011-5.

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Sobol, R. E., K. J. Scanlon, and E. Nestaas, eds. Gene Therapy. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-03577-1.

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Giacca, Mauro. Gene Therapy. Springer Milan, 2010. http://dx.doi.org/10.1007/978-88-470-1643-9.

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Kelly, Evelyn B. Gene therapy. Greenwood Press, 2007.

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Naff, Clay Farris. Gene therapy. Edited by Naff Clay Farris. Thomson/Gale, 2005.

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Services, Nestle Nutrition, ed. Gene therapy. Nestle Nutrition Services, 1996.

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Dr, Cooper David N., and Lemoine Nicholas R, eds. Gene therapy. Bios Scientific Publishers, 1996.

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1958-, Xanthopoulos Kleanthis, ed. Gene therapy. Springer, 1998.

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1952-, Sobol Robert E., ed. Gene therapy. Springer-Verlag, 1998.

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Chapitres de livres sur le sujet "Gene therapy"

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Akpolat, Veysi. "Gene Therapy Techniques;Physical and Chemical Methods." In Gene Therapy. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358824.2.

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Gene therapy is a technique that changes a person’s genes to treat or cure disease. To insert new genes directly into cells, scientists use a tool called a “vector.” Vectors are genetically engineered to deliver the genes needed to treat the disease. Various approaches can be used to deliver DNA into the cell with different gene transfer techniques. It is divided into two categories: 1. Biological vectors 2. Physical and Chemical methods. With gene transfers, the chance of treatment for diseases caused by defective genes increases.
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Gulhan, Baris. "Biological Methods Used in Gene Therapy." In Gene Therapy. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358824.3.

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Gene therapy is used to prevent or treat genetic diseases. To treat genetic diseases, transfer of genes that correct the effects of the mutation that causes the disease to the patient. In gene therapy, the therapeutic gene is transferred to target cells through a vector and viral vectors are most used. Retroviruses (lentiviruses), adenoviruses, adeno-associated viruses, and herpes virus vectors are common as viral vectors. In this section, biological methods used especially in gene therapy stages examined.
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Arvas, Hayati, and Zuhat Urakci. "Gene Therapy in Oncology." In Gene Therapy. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358824.5.

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Gene therapy refers to any method aimed at treating or alleviating a disease by genetically modifying a patien’s cells. Gene therapy for cancer is carried out by the integration of a genetic substance in a host cell by means of viral or non-viral vectors. Delivery of therapeutic nucleic acids such as genes, oligonucleotides, microRNAs (miRNA) or small combatant RNAs (siRNA) to cancer cells allows fighting cancer by inactivating oncogenes or reestablishing the production of cancer suppressor genes. Cancer remains a prevalent cause of death worldwide because of high recurrence rates after tradit
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Onur, Hakan. "Therapeutics in Pediatric Diseases." In Gene Therapy. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358824.4.

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Gene therapy is a treatment method that involves the alteration, correction or replacement of diseased genes in order to treat genetic diseases or alleviate their symptoms. Gene therapy in children stands out as a promising approach, especially in the treatment of inherited genetic diseases. This therapy aims to correct the source of the disease by targeting the underlying genetic causes of the disease. Gene therapy is usually applied with three main methods: Increasing Gene Expression, Gene Regulation, Gene Silencing Gene therapy is used especially in the treatment of the following diseases i
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Oral, Diclehan. "History of Gene Therapy." In Gene Therapy. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358824.1.

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Gene therapy aims to treat genetic diseases by introducing genetic material into cells to correct medical conditions or enhance health. This involves using nucleic acids, viruses, or genetically modified microorganisms to integrate therapeutic genetic material into the recipient’s genome. Recent advancements have significantly progressed gene therapy, focusing on treating inherited and acquired diseases like cancer and cardiovascular ailments through clinical trials. Overcoming delivery efficiency and immune reaction challenges is crucial for widespread clinical use. Gene therapy is categorize
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Silan, Coskun, and Buket GüNgor. "Licensing Processes for Gene Therapy Products: Approved and Pending Clinical Trials in the World and Turkey." In Gene Therapy. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358824.10.

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Gene therapy is a medical technology that aims to treat diseases by alteration, insertion or correction of genes. Gene therapy offers potential in treating many genetic diseases such as cystic fibrosis, blood cancers and neurological disorders. Preclinical processes include laboratory research, vector selection, gene editing studies and animal experiments. Clinical research phases consist of four phases: Phase I, safety and tolerability; Phase II, clinical efficacy and best dosages; Phase III, efficacy, safety and availability; Phase IV evaluates long-term effects and rare side effects. Gene t
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Lee, Thomas F. "Gene Therapy." In Gene Future. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-2760-6_6.

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Cornetta, Kenneth. "Gene Therapy." In Molecular Genetic Pathology. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-405-6_29.

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Douglas, Joanne T., and David T. Curiel. "Gene Therapy." In Molecular Biology of the Lung. Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8784-7_1.

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Choi, Vivian W., and R. Jude Samulski. "Gene Therapy." In Vogel and Motulsky's Human Genetics. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-37654-5_40.

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Actes de conférences sur le sujet "Gene therapy"

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Hubel, Allison, and Jeffrey McCullough. "Cryopreservation of Cultured Blood Cells for Use in Gene Therapy and Immunotherapy." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1318.

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Abstract The freezing characteristics of genetically manipulated lymphocytes and hematopoietic stem cells were studied. The water transport characteristics of stem cells which had been cultured and transduced with a therapeutic gene were different from that of a freshly isolated cells. Changes in the freezing characteristics for genetically transformed lymphocytes were also observed. Specifically, cryopreservation protocols developed for the fresh peripheral blood lymphocytes do not produce comparable survival rates for lymphocytes which have been cultured and transduced. These results indicat
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Nguyen, Phuc, Wei Qian, Yeachan Lee, et al. "Imaging guide stem cells and gene therapy for retinal diseases (Conference Presentation)." In Optical Biopsy XXIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, edited by Robert R. Alfano, Angela B. Seddon, Lingyan Shi, and Binlin Wu. SPIE, 2025. https://doi.org/10.1117/12.3044028.

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Hardwick, R. Alan, Bruce L. Levine, Carl H. June, et al. "Development of Closed Systems for Ex Vivo Cell Processing: Utility in Cell and Gene Therapy." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1316.

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Abstract Two examples are described in which cells were processed in a closed sterile fluid path by using custom-designed instruments, plastic bags and tubing sets, and a sterile connection device. In the first example, nucleated blood cells were collected from HIV+ patients. These cells were enriched for CD4+ cells and the CD4+ cells were expanded in the presence of immobilized CD3 and CD28 antibodies. The cells were then concentrated, washed, and re-infused. For the largest batches this resulted in 2.20 × 1010 cells with 86% viability and a CD4+ cell purity ≥ 95%. In two out of three re-infu
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"Advances in Gene Therapy." In International Conference on Cellular & Molecular Biology and Medical Sciences. Universal Researchers (UAE), 2016. http://dx.doi.org/10.17758/uruae.ae0916417.

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. Shcherbakova, S. A., P. E. Karitskaya, A. S. Chesnokova, I. O. Karpets, I. V. Evgenov, and D. V. Tseylikman. "DIFFERENTIALLY EXPRESSED GENES PREDICTING RESPONSE TO TAMOXIFEN THERAPY IN BREAST CANCER PATIENTS." In OpenBio-2023. ИПЦ НГУ, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-40.

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The study is aimed at finding genes mediating the response to tamoxifen therapy. Meta-analysis of the articles and the construction of gene networks revealed 7 genes that make a significant contribution to survival rates. For the purpose of validation, the approach of analysis of differential gene expression was chosen. The validation results revealed a high occurrence of the desired genes. The pattern of deviation of their expression from the reference values was combined with that indicated by other authors.
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Salimova, A. A., V. D. Drozd, D. S. Rybalko, A. A. Eldeeb, A. A. Dedovskayav, and D. M. Kolpashchikov. "ANTISENSE OLIGONUCLEOTIDES RELEASING CASSETTE FOR CANCER THERAPY." In OpenBio-2023. ИПЦ НГУ, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-49.

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Cancer gene therapy is a challenging area of research. Cancer therapy aims to target mutated genes that play crucial roles in tumorigenesis. However, this approach often encounters challenges such as low efficiency and off-target effects. Consequently, the number of drugs approved for clinical use remains limited. Here, we suggest a novel approach in cancer therapy — a DNA construct that is able to target vital housekeeping genes in a cancer-marker dependent manner.
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Dias, Heike Felipe Rangel, Rennyson Siqueira do Amaral, Marina Rosan Costa, Fernanda Melo Oliveira, José Henrique Amaral dos Santos, and Gabriela Capalbo Garrote. "Advances in gene therapy for neuromuscular diseases." In III Seven International Medical and Nursing Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/iiicongressmedicalnursing-041.

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Gene therapy has shown significant potential in the treatment of neuromuscular diseases such as Duchenne muscular dystrophy and spinal muscular atrophy. Advances in viral vector technology and gene editing techniques such as CRISPR-Cas9 have opened up new therapeutic possibilities. This paper explores the main advances, clinical outcomes and challenges associated with the application of this therapeutic approach. The literature review is based on recent studies on innovations in the field of gene therapy.
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Jiang, Xingyu. "Nanocluster-enabled Gene Therapy." In The 7th International Multidisciplinary Conference on Optofluidics 2017. MDPI, 2017. http://dx.doi.org/10.3390/optofluidics2017-04542.

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Sakr, N. "DEVELOPMENT OF GENE THERAPY FOR CAH." In Конференция «Перспективы применения генной терапии и биомедицинского клеточного продукта» с блоком летней школы для молодых ученых. Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр эндокринологии» Министерства здравоохранения Российской Федерации, 2022. http://dx.doi.org/10.14341/gnct-2022-51.

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Morgan, Jeffrey R. "Genetic Strategies for Tissue Engineering." In ASME 1996 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/imece1996-1165.

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Abstract Recent advances in molecular genetics have resulted in the development of new technologies for the introduction and expression of genes in human somatic cells. These gene transfer technologies have given rise to a potentially new field of medical treatment known as gene therapy. Gene therapy is broadly defined as the transfer of genetic material to cells or tissues in order to achieve a therapeutic effect for inherited as well as acquired diseases. We are exploring the potential application of gene transfer technologies to the field of tissue engineering and are interested in determin
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Rapports d'organisations sur le sujet "Gene therapy"

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Higgins, Paul J. Inducible Anti-Angiogenic Gene Therapy. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada437209.

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Agarwal, Nitin, Jorgen Magnus, John Kerwin, et al. Gene therapy process manufacturing maps. BioPhorum, 2020. http://dx.doi.org/10.46220/2020cgt003.

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Hayward, Simon W. Therapy Selection by Gene Profiling. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada491350.

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Hayward, Simon W. Therapy Selection by Gene Profiling. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada454306.

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Hayward, Simon W. Therapy Selection by Gene Profiling. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada426169.

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Higgins, Paul J. Inducible Anti-Angiogenic Gene Therapy. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada427186.

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Baylink, David J. Gene Therapy for Fracture Repair. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada431895.

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Segal, David J. Gene Therapy for Childhood Neurofibromatosis. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada609751.

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Buchsbaum, Donald J. Radiopharmaceutical and Gene Therapy Program. Office of Scientific and Technical Information (OSTI), 2006. http://dx.doi.org/10.2172/875908.

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Lau, William. Gene Therapy for Fracture Repair. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada474569.

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