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Articles de revues sur le sujet « Geraldine R »

Auteur : Grafiati

Publié le 25 juillet 2024

Mis à jour le 31 juillet 2025

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1

Yanes, Yurena, Geraldine A. Holyoak, David T. Holyoak, Maria R. Alonso, and Miguel Ibáñez. "A new Discidae subgenus and two new species (Gastropoda: Pulmonata) from the Canary Islands." Zootaxa 2911 (December 31, 2011): 43–49. https://doi.org/10.5281/zenodo.203498.

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Yanes, Yurena, Holyoak, Geraldine A., Holyoak, David T., Alonso, Maria R., Ibáñez, Miguel (2011): A new Discidae subgenus and two new species (Gastropoda: Pulmonata) from the Canary Islands. Zootaxa 2911: 43-49, DOI: 10.5281/zenodo.203498

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Rheindt, Frank E., Dewi M. Prawiradilaga, Hidayat Ashari, et al. "A lost world in Wallacea: Description of a montane archipelagic avifauna." Science 367 (January 10, 2020): 167–70. https://doi.org/10.1126/science.aax2146.

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Rheindt, Frank E., Prawiradilaga, Dewi M., Ashari, Hidayat, Suparno, Gwee, Chyi Yin, Lee, Geraldine W. X., Wu, Meng Yue, Ng, Nathaniel S. R. (2020): A lost world in Wallacea: Description of a montane archipelagic avifauna. Science 367: 167-170, DOI: 10.1126/science.aax2146

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Rheindt, Frank E., Dewi M. Prawiradilaga, Hidayat Ashar, Geraldine W. X. Lee, Meng Yue Wu, and Nathaniel S. R. Ng. "A lost world in Wallacea: Description of a montane archipelagic avifauna (supplement)." Science 36 (January 10, 2020): 1–104. https://doi.org/10.5281/zenodo.3608758.

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Rheindt, Frank E., Prawiradilaga, Dewi M., Ashar, Hidayat, Lee, Geraldine W. X., Wu, Meng Yue, Ng, Nathaniel S. R. (2020): A lost world in Wallacea: Description of a montane archipelagic avifauna (supplement). Science 36: 1-104, DOI: http://doi.org/10.5281/zenodo.3608758

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Haba, Jim, and Martin Farawell. "The Geraldine R. Dodge Poetry Festival Welcomes Teachers and Poets." English Journal 91, no. 3 (2002): 114. http://dx.doi.org/10.2307/821523.

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Gesteland, Beckyjo. "Western Images, Western Landscapes: Travels along U.S. 89 by Thomas R., Geraldine R. Vale." Western American Literature 26, no. 4 (1992): 366–67. http://dx.doi.org/10.1353/wal.1992.0129.

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Salvatore, Ricardo D. "Re-pensando Paisanos itinerantes. Respuesta a los comentarios de G. Davies, J. Farberman y R. Hora." Boletín del Instituto de Historia Argentina y Americana Dr. Emilio Ravignani, no. 52 (January 1, 2020): 149–65. http://dx.doi.org/10.34096/bol.rav.n52.7175.

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Ensayo analítico que nuclea el debate en torno al libro de Ricardo Salvatore (2018) Paisanos itinerantes. Orden estatal y experiencia subalterna en Buenos Aires durante la era de Rosas. Buenos Aires: Prometeo. Se ofrecen algunas reflexiones en torno a la obra y notas críticas sobre los comentarios de Geraldine Davies Lenoble, Judith Farberman y Roy Hora.

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Vale, Thomas R., Geraldine R. Vale, and Tom L. McKnight. "Western Images, Western Landscapes: Travels Along U.S. 89 by Thomas R. Vale and Geraldine R. Vale." Yearbook of the Association of Pacific Coast Geographers 53, no. 1 (1991): 245–47. http://dx.doi.org/10.1353/pcg.1991.0002.

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Lipscomb, Barney. "Reviewers for Journal of the Botanical Research Institute of Texas, Volume 17, 2023." Journal of the Botanical Research Institute of Texas 17, no. 2 (2023): 541. http://dx.doi.org/10.17348/jbrit.v17.i2.1333.

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Reviewers for the Journal of the Botanical Research Institute of Texas, Volume 17: Abbott, J. Richard—Ackerfield, Jennifer—Allen, Geraldine—Almeida, Odair José Garcia de—Barrett, Russell—Bennett, Bradley C.—Briggler, Malissa—Brokaw, Joshua M.—Carter, Richard—Cohen, James—Costea, Mihai—Cripps, Cathy—Dillon, Michael O.—Franck, Alan R.—Fuentes, Sara—Gandhi, Kanchi—Goldenberg, Renato—Gostel, Morgan—Graham, Shirley A.—Gustafson, Mark P.—Hansen, Bruce F.—Harrower, Emma—Hellenthal, Barbara J.—Hernández, Alexis López—Higinio Sandoval-Ortega, Manuel—Holmgren, Pat—Howard, Rebecca—Keeley, Sterling—Keith,

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Stilgoe, J. R. "U.S. 40 Today: Thirty Years of Landscape Change in America. By Thomas R. Vale and Geraldine R. Vale. (Madison: University of Wisconsin Press, 1983. xii & 198 pp. Photographs, maps, notes, index. $27.50.)." Environmental History Review 9, no. 1 (1985): 85–86. http://dx.doi.org/10.2307/3984127.

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Hughes, T. J., Gordon L. Davies, William J. Smyth, et al. "Reviews of Books." Irish Geography 7, no. 1 (2016): 137–50. http://dx.doi.org/10.55650/igj.1974.917.

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THE PERSONALITY OE IRELAND. HABITAT. HERITAGE AND HISTORY by E. Estyn Evans. Cambridge: University Press. 1973. 123 pp. £2.70. Reviewed by: T. J. HughesHISTORY IN THE ORDNANCE MAP: AN INTRODUCTION FOR IRISH READERS, by John H. Andrews. Dublin : the Ordnance Survey, l974. 63 pp. £1.00. Reviewed by: Gordon L. DaviesINISHKILLANE — CHANGE AND DECLINE IN THE WEST OF IRELAND. by Hugh Brody. London: Allen Lane, the Penguin Press, 1973. 286 pp. £2.95. Reviewed by: William J. SmythNORTHERN IRELAND. by M.A. Busteed (PROBLEM REGIONS OF EUROPE. edited by D. I. Srargill). London: Oxford University Press, 1

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Eugie, Mae R. Fernandez, D. Rodriguez Geraldine, S. Jimenez Jocelyn, and P.Pasco Fredgie. "PERCEPTIONS OF PUBLIC SECONDARY SCHOOL TEACHERS ON CONTINUING PROFESSIONAL DEVELOPMENT TOWARDS AN INTERVENTION PROGRAM." International Journal of Novel Research in Education and Learning 9, no. 2 (2022): 90–118. https://doi.org/10.5281/zenodo.6496890.

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<strong>Abstract:</strong> The purpose of this exploratory qualitative single case study was to describe the perceptions of five public secondary school teachers in East District of Malungon, Division of Sarangani. Qualitative research design using a single case study approach was employed to traverse and interpret the perceptions of Continuing Professional Development that leads to an intervention program. Five participants went through an in-depth interview to discover their perception using thematic analysis in analyzing the data. The data gathered were categorized into three themes: needs

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Morland, J. K. "Beginnings: The Social and Affective Development of Black Children. Edited by Margaret B. Spencer, Geraldine K. Brookins, and Walter R. Allen. Lawrence Erlbaum Associates, 1985. 375 pp. $34.50." Social Forces 65, no. 2 (1986): 578–79. http://dx.doi.org/10.1093/sf/65.2.578.

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Boo, Lawrence GS, and Adriana Uson Ong. "Book Review: Building International Investment Law: The First 50 Years of ICSID, by Meg N Kinnear, Geraldine R Fischer, Jara Mínguez Almeida, Luisa Fernanda Torres and Mairée Uran Bidegain (." Asian International Arbitration Journal 12, Issue 2 (2016): 259–65. http://dx.doi.org/10.54648/aiaj2016013.

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Cohen, Michael P. "The Colorado Front Range: A Century of Ecological Change. By Thomas T. Veblen and Diane C. Lorenz. Time and the Tuolumne Landscape: Continuity and Change in the Yosemite High Country. By Thomas R. Vale and Geraldine R. Vale." Environmental History Review 18, no. 3 (1994): 86–88. http://dx.doi.org/10.2307/3984716.

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Juvy, E. Millan, D. Rodriguez Geraldine, and Franz Mari R. Millado Kristoffer. "Impact of Work from Home among Teachers during the COVID-19 Pandemic: A Case Study." Impact of Work from Home among Teachers during the COVID-19 Pandemic: A Case Study 3, no. 1 (2022): 17–32. https://doi.org/10.5281/zenodo.6496987.

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<strong>Abstract:</strong> This study utilized a single case study design to describe the impact of Work from Home (WFH) alternative work arrangement among the five grade chairpersons of Saavedra Saway Central Elementary School for the School-Year 2020-2021. This study used the key participant interview approach to gather the needed data. Findings of the study revealed the case of the five teachers of Saavedra Saway Central Elementary School and their perspective on the impact of work from home among teachers as the challenge of connectivity, ups and downs of productivity, and two sides of job

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HAMANA, U. SINANGKAD, B. GUAZA GERMAN, and D. RODRIGUEZ GERALDINE. "MANAGEMENT SKILLS AND ITS EFFECT TO THE REFORMATORY AND DRUG PREVENTION PROGRAMS OF 109TH BASE COMMAND OF MORO ISLAMIC LIBERATION FRONT." International Journal of Recent Research in Thesis and Dissertation (IJRRTD) 4, no. 2 (2023): 61–78. https://doi.org/10.5281/zenodo.8227894.

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<strong>Abstract:</strong> This study determined the management skills and its effect on the implementation of reformatory and drug prevention program of 109th Base Command of Moro Islamic Liberation Front. A total of 154 respondents from of Bangsamoro Islamic Armed Forces and Personnel of Reformatory Center. A descriptive correlational research design was employed. In analyzing the data, weighted mean and Pearson r were utilized. Results disclosed that management skills of individual were moderately skillful. Moreover, the implementation of reformatory program were moderately implemented. Fur

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Rodwell, N., G. Hassett, P. Bird, T. Pincus, and J. Descallar. "AB0249 RHEUMETRIC QUANTITATIVE 0-10 PHYSICIAN ESTIMATES OF INFLAMMATION, DAMAGE, AND DISTRESS IN RHEUMATOID ARTHRITIS: VALIDATION AGAINST REFERENCE MEASURES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1308.3–1309. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4992.

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BackgroundA physician global assessment (DOCGL) distinguishes active from control treatments in rheumatoid arthritis (RA) effectively in clinical trials. However, RA trials select for patients who have high inflammatory activity, generally only 5-30% of all RA patients. In routine care, DOCGL, and all clinical RA measures and indices, may be elevated not only by inflammatory activity but also by joint damage and/or patient distress, complicating interpretation of RA indices and clinical decisions. A RheuMetric checklist provides feasible physician 0-10 subscale estimates of inflammation (DOCIN

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Schoep, Ilse. "Leslie Preston Day, HeidiM.C. Dierckx, Kimberly Flint-Hamilton, Geraldine C. Gesell, Kevin T. Glowacki, Nancy L. Klein, David S. Reese and Lynn M. Snyder. Kavousi IIC: The Late Minoan IIIC Settlement at Vronda. Specialist Reports and Analyses. Kavousi." Journal of Greek Archaeology 2 (January 1, 2017): 404–8. http://dx.doi.org/10.32028/jga.v2i.597.

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This is the third volume in the series publishing the cleaning and excavation of the site of Vronda in the Kavousi area. The first volume, Kavousi IIA, was devoted to the excavation, stratigraphy, and architecture of the houses and their finds on the summit of the Vronda ridge (Buildings A-B, C-D, J-K, and Q), along with earlier (Building P) and later (Building R) structures around them. The second volume, Kavousi IIB , focuses on the buildings on the slopes of the Vronda ridge (Building Complexes E, I-O-N, and L-M, Building F, the pottery kiln, as well as other areas excavated on the peripher

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Franken, Ingrid, Steven Ketelaars, Carmen Rubio-Alarcón, et al. "Abstract 2496: Molecular characterization of stage III colon cancer patients with recurrence after adjuvant chemotherapy." Cancer Research 84, no. 6_Supplement (2024): 2496. http://dx.doi.org/10.1158/1538-7445.am2024-2496.

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Abstract Introduction: Patients with stage III colon cancer are routinely treated with resection followed by adjuvant chemotherapy (ACT) with a fluoropyrimidine and oxaliplatin. This one-size-fits-all approach does not account for heterogeneity in tumor biology and fails to cure ~30% of patients, highlighting the urgency for biomarkers to better understand and predict resistance to ACT or to offer alternative targeted treatment. Aim: To identify molecular characteristics predictive of resistance to standard ACT in stage III colon cancer. Methods: Patients with resected stage III colon cancer w

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Cagigal Montalbán, Ekain. "La maldición de los Archer. Una familia irlandesa al servicio del Consulado de Bilbao (siglo XVIII)." Vínculos de Historia Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, no. 12 (June 28, 2023): 330–42. http://dx.doi.org/10.18239/vdh_2023.12.17.

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RESUMENMiguel Archer forma parte del enorme contingente de exiliados que dejaron Irlanda durante el siglo xviii y se establecieron a comienzos de la centuria en la villa de Bilbao. Junto a su mujer, María Geraldino –también irlandesa–, crio una próspera y exitosa familia, al tiempo que se posicionaba sólidamente en el comercio y la sociedad bilbaína. Archer trabajó en múltiples ámbitos para el Consulado de Bilbao, vínculo que su hijo Miguel hizo perdurar y engrandecer durante años. El padre ejerció durante más de 30 años como arqueador y corredor de navíos en el puerto bilbaíno, cargo que fue

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Ledesma-Bazan, Sabrina, Florencia Cascardo, Juan Bizzotto, et al. "Abstract 25: Competing Endogenous RNA (ceRNA) Networks Implicated in Prostate Cancer Progression to Castration Resistance Identified Through Bioinformatics Analyses." Cancer Epidemiology, Biomarkers & Prevention 32, no. 6_Supplement (2023): 25. http://dx.doi.org/10.1158/1538-7755.asgcr23-abstract-25.

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Abstract Purpose: Long non-coding RNAs (lncRNAs) regulate several biochemical pathways and contribute to the pathophysiology of cancer. In previous analyses, we identified 27 lncRNAs whose expression respond to hormone therapy in prostate cancer patients. Furthermore, in castration-resistant prostate cancer (CRPC), their levels were restored to those observed in therapy-naïve primary tumors. Nevertheless, lncRNAs contribution in tumorigenesis is still not understood. Since one mechanism of action of lncRNAs is acting as sponges of miRNAs, our main goal was to identify lncRNA-miRNA-mRNA network

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Schwebel, Stephen M. "Building International Investment Law: The First 50 Years of ICSID. Edited by Meg Kinnear , Geraldine R. Fischer , Jara Mínguez Almeida , Luisa Fernanda Torres and Mairée Uran Bidegain . Alphan aan den Rijn: Wolters Kluwer, 2015. Pp. xlix, 776. Index. $263." American Journal of International Law 111, no. 4 (2017): 1085–86. http://dx.doi.org/10.1017/ajil.2017.68.

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Van der Horst-Bruinsma, I., R. Bolce, T. Hunter, et al. "POS0228 BASELINE CHARACTERISTICS AND TREATMENT RESPONSE TO IXEKIZUMAB CATEGORISED BY SEX IN RADIOGRAPHIC AND NON-RADIOGRAPHIC AXIAL SPONDYLARTHRITIS PATIENTS THROUGH 52 WEEKS: DATA FROM 3 PHASE III, RANDOMIZED, CONTROLLED TRIALS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 333.2–334. http://dx.doi.org/10.1136/annrheumdis-2021-eular.684.

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Background:Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the axial skeleton comprising two subtypes within the same spectrum: radiographic (r-axSpA) and non-radiographic (nr-axSpA). Previous studies have shown that clinical presentation and treatment response of males and females may differ1 despite similar disease burden.2 Ixekizumab (IXE), a high-affinity monoclonal antibody that selectively targets interleukin-17A, has demonstrated superior efficacy to placebo in the treatment of patients with r-axSpA (COAST-V/W [bDMARD- naïve/TNFi-experienced]) and nr-axSpA (COAST-X

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Fitzpatrick, Mike. "Mac Giolla Phádraig Clerics 1394-1534 AD: Part I." Journal of the Fitzpatrick Clan Society 2 (October 1, 2021): 42–65. http://dx.doi.org/10.48151/fitzpatrickclansociety00521.

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Mac Giolla Phádraig Clerics 1394-1534 AD is a three-part series, which provides an account of all known individual Mac Giolla Phádraig clerics in the late medieval era and details their temporalities, occupations, familial associations, and broader networks. The ultimate goal of the series is the full contextualisation of all available historical records relating to Mac Giolla Phádraig clerics alongside the genealogical record that can be extracted by twenty-first century science – that being the science of Y-DNA. The Papal Registers, in particular, record numerous occurrences of Mac Giolla Ph

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Lin, Sherry. "Reviewer Acknowledgements for Higher Education Studies, Vol. 9, No. 4." Higher Education Studies 9, no. 4 (2019): 226. http://dx.doi.org/10.5539/hes.v9n4p226.

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Higher Education Studies wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.  Higher Education Studies is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please find the application form and details at http://recruitment.ccsenet.org and e-mail the completed application form to hes@ccsenet.org.  Reviewers for Volume 9, Number 4  Abdelaziz

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Athans, Sarah R., Nithya Krishnan, Swathi Ramakrishnan, et al. "Abstract 1422: STAG2-mediated gene expression programs promote invasion in muscle invasive bladder cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 1422. https://doi.org/10.1158/1538-7445.am2025-1422.

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Abstract Stromal antigen 2 (STAG2) is associated with worse overall and progression free survival of muscle invasive bladder cancer (MIBC) patients. Furthermore, STAG2 expression is associated with motility and invasiveness of MIBC cell in vitro, suggesting that STAG2 acts as an oncogene in MIBC. In normal cells, STAG2 assists with sister chromatid cohesion, DNA damage repair, and maintenance of genome organization as part of the cohesin complex. However, mechanisms underlying the pro-oncogenic function of STAG2 in MIBC remain unknown. After knockdown of STAG2 in T24 MIBC cells, thousands of g

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Rubio-Alarcon, Carmen, Steven L. Ketelaars, Ingrid A. Franken, et al. "Abstract 3358: PLCRC-PROVENC3: assessing the prognostic value of post-surgery liquid biopsy cell-free circulating tumor DNA in stage III colon cancer patients." Cancer Research 83, no. 7_Supplement (2023): 3358. http://dx.doi.org/10.1158/1538-7445.am2023-3358.

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Abstract Introduction: Surgery followed by adjuvant chemotherapy (ACT) is standard of care in stage III colon cancer. However, 50% of the patients would be cured by surgery alone and are being overtreated, while 30-35% will experience a recurrence despite adjuvant treatment, resulting in only 15-20% of the patients benefitting from ACT. Therefore, there is a need for prognostic biomarkers to better stratify this group of patients for ACT decisions. Recent observational and interventional studies in non-metastatic colon cancer have shown that detection of cell-free circulating tumor DNA (ctDNA)

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Pascual, Gastón Mario, Agustina Sabater, Juan Bizzotto, et al. "Abstract 3420: Androgen receptor (CAG)n polymorphism: A genomic marker for prostate cancer prognosis independent of histopathological parameters." Cancer Research 84, no. 6_Supplement (2024): 3420. http://dx.doi.org/10.1158/1538-7445.am2024-3420.

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Abstract The androgen receptor (AR) serves as a pivotal transcription factor in prostate cancer (PCa) development. Its transcriptional activity is linked to the number of glutamines in the N-terminal domain. While current screening for PCa and prognostic biomarkers include serum prostate-specific antigen (PSA) levels and histopathological characteristics (specifically, ISUP grade and margin involvement), the heterogeneity of these tumors underscores the need for additional markers to enhance clinical management. Thus, this study aimed at characterizing an Argentinian PCa patient cohort based o

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Crnovsanin, Nerma, Carmen Rubio Alarcon, Vincent Pappalardo, et al. "Abstract 3259: Beyond tumor size: Biological and clinical predictors of ctDNA shedding in colon cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 3259. https://doi.org/10.1158/1538-7445.am2025-3259.

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Abstract Introduction: Circulating tumor DNA (ctDNA) detection in liquid biopsies has multiple applications in oncology and is becoming part of routine diagnostics. However, the inter-patient variability regarding ctDNA presence and levels in blood hampers the interpretation of ctDNA testing results. A better understanding of the underlying biology of ctDNA shedding could facilitate ctDNA testing implementation, by identifying the patients for whom the test might be informative to guide clinical decisions. This study aims to explore the clinicopathological and molecular characteristics influen

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Kerr, Donal A. "Daniel O’Connell—political pioneer. Edited by Maurice R. O’Connell. Pp 147, illus. Dublin: Institute of Public Administration, for DOCAL (Daniel O’Connell Association Ltd). 1991. IR£9.95. - The noblest agitator: Daniel O’Connell and the German Catholic movement, 1830–1850. By Geraldine F. Grogan. Pp 224. Dublin: Veritas. 1991. IR£14.95." Irish Historical Studies 29, no. 115 (1995): 411–12. http://dx.doi.org/10.1017/s0021121400012049.

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Alarcon, Carmen Rubio, Andrew Georgiadis, Ingrid A. Franken, et al. "Abstract 6559: Clinical validity of post-surgery circulating tumor DNA testing in stage III colon cancer patients treated with adjuvant chemotherapy: The PROVENC3 study." Cancer Research 84, no. 6_Supplement (2024): 6559. http://dx.doi.org/10.1158/1538-7445.am2024-6559.

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Abstract Introduction: Surgery followed by adjuvant chemotherapy (ACT) is standard of care in stage III colon cancer. However, only 15-20% of patients benefit from ACT, as half of patients are cured by surgery, and 25-30% still experience a recurrence. Detection of circulating tumor DNA (ctDNA) after resection of the primary tumor is a strong prognostic biomarker in non-metastatic colon cancer and offers a promising approach to better stratify stage III colon cancer patients for ACT treatment decisions. Aim: The PROVENC3 study aims to determine the clinical validity of post-surgery ctDNA detec

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Dumilag, Richard V., Ferdinand S. Dumago, Rea Kissel R. Cabudoy, et al. "The Ulvophyceae (Chlorophyta) of eastern Sorsogon, Philippines, including Halimeda magnicuneata sp. nov. (Bryopsidales)." Botanica Marina 63, no. 5 (2020): 439–53. https://doi.org/10.1515/bot-2020-0017.

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Dumilag, Richard V., Dumago, Ferdinand S., Cabudoy, Rea Kissel R., Peralta, Mark Christian E., Li, Camille C., Gamus, Glenn Cedrick V., Romero, Rose Glendelyn T., Yap, Sandra L., Roleda, Michael Y., Geraldino, Paul John L., Verbruggen, Heroen, Leliaert, Frederik, Draisma, Stefano G.A., Liao, Lawrence M., Kraft, Gerald T. (2020): The Ulvophyceae (Chlorophyta) of eastern Sorsogon, Philippines, including Halimeda magnicuneata sp. nov. (Bryopsidales). Botanica Marina (Warsaw, Poland) 63 (5): 439-453, DOI: 10.1515/bot-2020-0017, URL: https://doi.org/10.1515/bot-2020-0017

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Alarcon, Carmen Rubio, Dave E. van der Kruijssen, Suzanna J. Schraa, et al. "Abstract 536: Prognostic value of post-surgery liquid biopsy cell-free circulating tumor DNA in stage III colon cancer patients - PLCRC-PROVENC3 study." Cancer Research 82, no. 12_Supplement (2022): 536. http://dx.doi.org/10.1158/1538-7445.am2022-536.

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Abstract Introduction: Stage III colon cancer patients are offered surgery followed by adjuvant chemotherapy (ACT) according to Dutch clinical guidelines. However, only 15-20% of the patients benefit from ACT: 50% would be cured by surgery alone and are thus being overtreated, while 30-35% will experience a recurrence despite adjuvant treatment. Therefore, there is a need for prognostic biomarkers to better stratify this group of patients for ACT. Recent studies in non metastatic colorectal cancer have shown that detection of cell-free circulating tumor DNA (ctDNA) in blood after surgery indic

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Sabater, Agustina A., Ayelen R. Toro, Pablo A. Sanchis, et al. "Abstract 2437: HMOX1 modulates tumor stemness and metastatic properties in prostate cancer." Cancer Research 83, no. 7_Supplement (2023): 2437. http://dx.doi.org/10.1158/1538-7445.am2023-2437.

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Abstract Eighty percent of prostate cancers (PCa) metastasize to bone, showing a significant source of patient morbidity. PCa stem-like cells (PCSCs) are capable to quiescently outlast retaining the ability to proliferate and regenerate, consequently remaining able to develop therapy-resistant tumors and metastatic lesions. We have previously reported that the overexpression of heme oxygenase 1 (HO-1), the rate limiting enzyme in heme degradation, leads to a less aggressive PCa phenotype. However, its effect on metastasis-stemness (MS) remains unknown. In this work, we address the biological s

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van Steijn, Denise E., Remond J. Fijneman, Geraldine R. Vink, et al. "Abstract 3673: Monitoring treatment response in patients with metastatic colorectal cancer using cfDNA fragmentomics testing: The DOLPHIN trial." Cancer Research 84, no. 6_Supplement (2024): 3673. http://dx.doi.org/10.1158/1538-7445.am2024-3673.

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Abstract Background: Accurate monitoring of treatment response in patients with metastatic colorectal cancer (mCRC) is important to decide when to adjust treatment regimen or to proceed to local therapy of metastases. At present, clinical response is determined by computed tomography (CT) imaging-based assessment of changes in tumor size. However, this monitoring approach is constrained by limited sensitivity in detecting lymph node and peritoneal metastases, as well as inter-reader variability. Detection of circulating tumor DNA (ctDNA) is indicative of the amount of neoplastic cells and may

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Alarcon, Carmen Rubio, Soufyan Lakbir, Elisabeth J. van Bree, et al. "Abstract 2053: Hemizygous focal deletions in MACROD2 alter tumor biology and genomic instability in colorectal cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 2053. https://doi.org/10.1158/1538-7445.am2025-2053.

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Abstract Introduction: MACROD2 is a large gene located within a common fragile site (CFS), a genomic region that is vulnerable to acquiring focal deletions under replicative stress. Structural variants (SVs) in MACROD2 are highly prevalent in patients with colorectal cancer (CRC), but their putative role in tumor initiation and progression remains to be established. Aim of this study: In silico and in vitro characterization of the effects of somatic SVs in MACROD2 in CRC initiation and evolution. Methods: Five datasets were used for in silico characterization of SVs in MACROD2: HMF (metastatic

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Salkeni, Mohamad Adham, Geraldine O’Sullivan Coyne, Naoko Takebe, et al. "Abstract CT115: Safety and efficacy of Anti-PD-L1 antibody MEDI4736 (durvalumab) in combination with capecitabine in patients with advanced solid tumors (DURVA+)." Cancer Research 82, no. 12_Supplement (2022): CT115. http://dx.doi.org/10.1158/1538-7445.am2022-ct115.

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Abstract Background: It is hypothesized that chemotherapy alters the tumor microenvironment (TME) by increasing T cell infiltration and enhancing antigen presentation to T cells, and thereby may enhance immune-mediated cytotoxicity and tumor response to immunotherapy. The goal of this trial (DURVA+) is to evaluate and compare the immune-modulating effects of six different chemotherapy agents with Durvalumab (D), a PD-L1 checkpoint inhibitor. We report here the first analysis of one of the arms of DURVA+: D plus capecitabine (C). Methods: This is a non-randomized phase 2 trial for adult patient

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Wisse, Pieter Henk Abraham, Carmen Rubio-Alarcon, Suzanna J. Schraa, et al. "Abstract 6079: Comparison of FIT and cell-free DNA analyses for detection of individuals with colorectal cancer in population based screening." Cancer Research 84, no. 6_Supplement (2024): 6079. http://dx.doi.org/10.1158/1538-7445.am2024-6079.

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Abstract Background The fecal immunochemical test (FIT) is widely used in population based colorectal cancer (CRC) screening programs. Recently, circulating cell-free DNA (cfDNA) analyses have emerged as a new avenue for early cancer detection. The performance of cfDNA methods in comparison with FIT is currently unknown. The present study compared pre-operative cfDNA analyses to FIT for detection of patients with CRC who participated in a population-based screening program. Methods In the Dutch national CRC screening program, individuals aged 55-75 years are biennially invited to perform a sin

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Canzoniero, Jenna V., Archana Balan, Jillian Phallen, et al. "Abstract 3366: A machine learning approach to determine the cellular origin of variants in liquid biopsies." Cancer Research 83, no. 7_Supplement (2023): 3366. http://dx.doi.org/10.1158/1538-7445.am2023-3366.

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Abstract Introduction: Targeted next-generation sequencing (NGS) of cell-free DNA in plasma, referred to as liquid biopsy, has become a valuable diagnostic tool in clinical oncology. However, detection of variants related to clonal hematopoiesis (CH) is a major confounder that significantly impairs the clinical utility of liquid biopsies. Here we developed a machine-learning model to determine tumor versus CH origin of variants identified in plasma-only NGS. Methods: We assembled a training cohort of 352 variants identified by targeted deep plasma sequencing from 199 patients with stage I-IV b

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Ferry-Galow, Katherine V., Kristin K. Fino, Geraldine O'Sullivan Coyne, et al. "Abstract CT263: Atezolizumab clinical trial biopsies reveal varied immune landscapes in clear cell sarcoma and chondrosarcoma." Cancer Research 84, no. 7_Supplement (2024): CT263. http://dx.doi.org/10.1158/1538-7445.am2024-ct263.

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Abstract Introduction: Clear cell sarcoma (CCS) constitutes &lt;1% of sarcomas and frequently presents in adolescents and young adults. Chondrosarcoma is one of the most common bone malignancies in adults, occurring as conventional chondrosarcoma (CS) or the more-aggressive dedifferentiated chondrosarcoma (dCS). There is no standard of care therapy approved for these malignancies. The activity of immune checkpoint inhibition (ICI) in alveolar soft part sarcoma, together with case reports of ICI activity in these other sarcoma subtypes, prompted us to conduct a phase 2 clinical trial of ate

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van Steijn, Denise E., Jamie Medina, Lorenzo Rinaldi, et al. "Abstract 3241: Cell-free DNA fragmentomes for treatment response monitoring in patients with metastatic colorectal cancer: the DOLPHIN study." Cancer Research 85, no. 8_Supplement_1 (2025): 3241. https://doi.org/10.1158/1538-7445.am2025-3241.

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Abstract Accurate monitoring of treatment response in patients with metastatic colorectal cancer (mCRC) is essential for optimizing therapeutic strategies. Current response evaluation relies on imaging-based assessment of tumor size changes. However, this approach is limited by suboptimal sensitivity for detecting lymph node and peritoneal metastases, as well as inter-reader variability. Circulating tumor DNA (ctDNA) is indicative of the number of neoplastic cells and could have clinical value to CT imaging for assessment of treatment response. A mutation- and tumor-independent ctDNA assay was

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Takebe, Naoko, James Nguyen, Shivaani Kummar, et al. "Abstract CT168: Randomized phase 2 trial of sunitinib or cediranib in alveolar soft part sarcoma." Cancer Research 82, no. 12_Supplement (2022): CT168. http://dx.doi.org/10.1158/1538-7445.am2022-ct168.

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Abstract Background: Alveolar soft part sarcoma (ASPS) is a rare, highly vascular tumor with few effective treatment options. Cediranib (C) and sunitinib (S) are potent oral inhibitors of all 3 VEGF receptors. Cediranib showed substantial single-agent activity (objective response rate [ORR] = 35%) in our previous trial in patients (pts) with metastatic ASPS (NCT00942877). Here we report a phase 2 randomized multicenter trial of single agent C or S in pts with ASPS (NCT01391962). Methods: We conducted a multicenter phase 2 trial with an optimal 2-stage design targeting an ORR of 40%. Enrolled p

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Ko, Brian, Geraldine H. O'Sullivan Coyne, Abdul Rafeh Naqash, et al. "Abstract B138: Pharmacodynamics-driven phase 2 trial of talazoparib in patients with advanced solid tumors and aberrations in genes involved in DNA damage response." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): B138. http://dx.doi.org/10.1158/1535-7163.targ-23-b138.

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Abstract Background: Talazoparib is a poly (ADP-ribose) polymerase inhibitor (PARPi) with increased trapping of PARP-DNA complexes compared to other PARPi in clinical development. Talazoparib has single-agent synthetic lethality in BRCA1/2- and PTEN-deficient cell lines, has potent antitumor activity in animal models of tumors harboring mutations in DNA repair pathways, and has FDA-approved indications in advanced BRCA-mutated and HER2-negative breast cancer and in homologous recombination repair gene-mutated metastatic castration-resistant prostate cancer in combination with enzalutamide. Thi

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SUASSUNA, Lívia, and Sabrina Leite FELIX. "SABERES EM MOVIMENTO NO ESTÁGIO DE REGÊNCIA DE TURMA: O ENSINO DE ANÁLISE LINGUÍSTICA POR GRADUANDOS DE LETRAS." Trama 17, no. 41 (2021): 09–27. http://dx.doi.org/10.48075/rt.v17i41.26732.

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Neste estudo pretendemos analisar o modo como alunos da licenciatura em Letras-Português da Universidade Federal de Pernambuco, durante o estágio curricular, atuam para ensinar seus alunos a refletir sobre a língua, concretizando um dos eixos de ensino desse componente curricular que é a análise linguística. A pesquisa, do tipo qualitativo-descritiva, teve como corpus projetos e relatórios de estágio, além de depoimentos dos estagiários, captados no seminário de encerramento das atividades de regência de turma do ensino fundamental. Para montar o referencial teórico, buscamos autores que trata

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Bharathesree, R., N. Murali, R. Saravanan, and R. Anilkumar. "Polymorphism of Keratin - associated protein (KAP) 3.2 gene in Sandyno and Nilagiri breeds of sheep." Biolife 5, no. 1 (2022): 48–52. https://doi.org/10.5281/zenodo.7357245.

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<strong>ABSTRACT</strong> <strong>ABSTRACT</strong> Polymorphic variants of keratin-associated protein (<em>KAP</em>) 3.2 gene in Sandyno and Nilagiri breeds of sheep were investigated. Genomic DNA was isolated from blood samples of 125 Sandyno, Nilagiri and Dorset x Nilagiri breeds and 76 numbers of wool samples were collected and processed. A 393 bp segment was amplified by PCR using ovine specific primers for <em>KAP</em> 3.2 gene. The genotyping was done by using PCR-SSCP. <em>KAP</em> 3.2 gene locus revealed 3 genotypes, viz. <em>AA, AB</em> and <em>BB</em> with a frequency of 0.84, 0.16

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ANDRADE, Francisco Rogiellyson Da Silva, Edla Freitas RIBEIRO, and Sandra Maia Farias VASCONCELOS. "A (RES)SIGNIFICAÇÃO DO ENSINO DE LÍNGUA MATERNA PROPICIADA POR NARRATIVAS DE VIDA PRODUZIDAS EM ESTÁGIO DE OBSERVAÇÃO NO CONTEXTO PANDÊMICO." Trama 17, no. 41 (2021): 28–44. http://dx.doi.org/10.48075/rt.v17i41.26856.

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Sob o viés metodológico da etnossociologia clínica (ANDRADE, 2019), este artigo analisa narrativas de vida coletadas em uma disciplina de estágio de observação do curso de Letras: Língua Portuguesa da Universidade Federal do Ceará. Em vista da impossibilidade das aulas presenciais, por conta da pandemia de Covid-19, as práticas de formação docente tiveram que ser repensadas. Nesse contexto, as narrativas de vida surgem como catalisadoras de experiências, permitindo ao professor em formação reconfigurar saberes e conhecimentos adquiridos em seu itinerário, (res)significando concepções de lingua

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Cordeiro, Ana Luiza, and Nivea Rohling. "IDENTIDADE, GÊNERO E TRANSGENERIDADE: A CONSTRUÇÃO DO SER-MULHER NO VIDEODOCUMENTÁRIO “LAERTE-SE”." Revista X 14, no. 4 (2019): 135. http://dx.doi.org/10.5380/rvx.v14i4.66077.

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Levando em conta a acepção de que as identidades e os modos de existirsão socialmente produzidos a partir de diferentes práticas discursivas, forjandoprocessos de diferenciação dos sujeitos e legitimando o pertencimento a determinados grupos, o presente artigo analisa os discursos sobre o ser-mulher trans* no videodocumentário Laerte-se, considerando as múltiplas vozes que ecoam nessa narrativa multissemiótica. Para tanto, a análise tomou como base os estudos sobre gênero, sexualidade e identidade tais como: Beauvoir (1980), Butler (2001), De Lauretis (1994), Geraldi (2010), Moita Lopes (2013)

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FISCHER, Adriana, and Elizângela Aparecida Mattes da SILVA. "PRÁTICAS DE ESCRITA EM AULAS DE LÍNGUA PORTUGUESA NA VOZ DE ALUNOS DO ENSINO FUNDAMENTAL." Trama 14, no. 33 (2018): 73–83. http://dx.doi.org/10.48075/rt.v14i33.18578.

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O objetivo deste artigo é analisar, a partir de enunciados de alunos, situações de produção em práticas de escrita, de aulas de Língua Portuguesa (LP) do Ensino Fundamental de uma escola municipal do Alto Vale do Itajaí, SC. Os enunciados integram uma pesquisa de cunho qualitativo, sob a perspectiva dialógica da linguagem. Os dados advêm de entrevista coletiva semiestruturada realizada com alunos de um 6º e um 9º ano em 2014. Os resultados indicam que, para esses alunos, as produções de escrita são comumente respostas a uma prática social escolarizada. Por outro lado, tais propostas de escrita

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Bacheler, Nathan M., Zeb H. Schobernd, David J. Berrane, Christina M. Schobernd, Warren A. Mitchell, and Nathan R. Geraldi. "When a trap is not a trap: converging entry and exit rates and their effect on trap saturation of black sea bass (Centropristis striata)." ICES Journal of Marine Science 70, no. 4 (2013): 873–82. http://dx.doi.org/10.1093/icesjms/fst062.

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Abstract Bacheler, N. M., Schobernd, Z. H., Berrane, D. J., Schobernd, C. M., Mitchell, W. A., and Geraldi, N. R. 2013. When a trap is not a trap: converging entry and exit rates and their effect on trap saturation of black sea bass (Centropristis striata) – ICES Journal of Marine Science, 70: 873–882. Catch rates are often used to index the abundance of marine organisms, but catch saturation (i.e. declining catch rate as fishing time increases) can decouple catch and abundance. Researchers have struggled to account for saturation when using trap catch to infer population dynamics. We used the

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SARMENTO, Cristiana Abrantes, and José Cezinaldo Rocha BESSA. "UMA ANÁLISE DA PROPOSTA DE TRABALHO COM O GÊNERO DO DISCURSO NOTÍCIA EM PLANO DE AULA DE LÍNGUA PORTUGUESA DO PORTAL DO PROFESSOR." Trama 16, no. 37 (2020): 34–46. http://dx.doi.org/10.48075/rt.v16i37.23683.

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Este artigo tem como objetivo analisar o trabalho com gênero do discurso em plano de aula de língua portuguesa do Portal do Professor. O foco recai sobre o exame dos aspectos temáticos, estilísticos e composicionais do gênero do discurso notícia explorado em um plano recortado como corpus do estudo. Interessa responder a seguinte questão: propõe-se efetivamente um trabalho com gênero do discurso e que considere suas especificidades? Como ancoragem teórica, o trabalho assume, principalmente, estudos do denominado Círculo de Bakhtin (BAKHTIN; 2016; MEDVIÉDEV, 2016; VOLÓCHINOV, 2017) sobre a abor

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