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Articles de revues sur le sujet « Germline gene editing »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 25 juillet 2025

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1

Cwik, Bryan. "Intergenerational monitoring in clinical trials of germline gene editing." Journal of Medical Ethics 46, no. 3 (2019): 183–87. http://dx.doi.org/10.1136/medethics-2019-105620.

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Design of clinical trials for germline gene editing stretches current accepted standards for human subjects research. Among the challenges involved is a set of issues concerning intergenerational monitoring—long-term follow-up study of subjects and their descendants. Because changes made at the germline would be heritable, germline gene editing could have adverse effects on individuals’ health that can be passed on to future generations. Determining whether germline gene editing is safe and effective for clinical use thus may require intergenerational monitoring. The aim of this paper is to id

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Sugarman, Jeremy. "Ethics and germline gene editing." EMBO reports 16, no. 8 (2015): 879–80. http://dx.doi.org/10.15252/embr.201540879.

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Mason, Veronica R. J. M. "Hurtling toward Germline Gene Editing." Ethics & Medics 44, no. 8 (2019): 1–4. http://dx.doi.org/10.5840/em201944811.

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Genetic enhancement runs up against several moral issues, perhaps the chief of which is the inevitable eugenic attitude it would foster and the associated inequality it would create between those who have the “proper” enhancements and those who do not. For simplicity’s sake, this analysis leaves aside questions related to genetic enhancement and considers only changes made for therapeutic purposes. Regardless, most of the censure of He Jiankui focuses on the results of human modification and often overlooks the prior question of how gene editing research itself conducted. Germline gene editing

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Cartier-Lacave, Nathalie, Robin Ali, Seppo Ylä-Herttuala, et al. "Debate on Germline Gene Editing." Human Gene Therapy Methods 27, no. 4 (2016): 135–42. http://dx.doi.org/10.1089/hgtb.2016.28999.deb.

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Nalley, Catlin. "Germline Gene Editing for Deafness." Hearing Journal 73, no. 2 (2020): 28. http://dx.doi.org/10.1097/01.hj.0000654908.10936.e1.

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Ewuoso, Cornelius. "Germline Gene Editing Applications and the Afro-communitarian Ubuntu Philosophy." Filosofia Theoretica: Journal of African Philosophy, Culture and Religions 12, no. 1 (2023): 1–12. http://dx.doi.org/10.4314/ft.v12i1.1.

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Germline gene editing has many applications or uses. This article focuses on specific applications. Specifically, the article draws on a moral norm arising from the thinking about the value of communal relationships in the Afro-communitarian ubuntu philosophy to interrogate key issues that specific applications of germline gene editing – for xeno-transplantation, agriculture and wildlife – raise. The article contends that the application of germline gene editing in these areas is justified to the extent that they foster the capacity to relate with others and to be communed with by others. The

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Gyngell, Christopher, Thomas Douglas, and Julian Savulescu. "The Ethics of Germline Gene Editing." Journal of Applied Philosophy 34, no. 4 (2016): 498–513. http://dx.doi.org/10.1111/japp.12249.

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Ranisch, Robert, Tina Rudolph, Hans-Joachim Cremer, and Nikolaus Knoepffler. "Ordo-Responsibility for Germline Gene Editing." CRISPR Journal 3, no. 1 (2020): 37–43. http://dx.doi.org/10.1089/crispr.2019.0040.

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Savvina, Olga V. "Genetic Modification of Human Embryos: Limits." Ethical Thought 22, no. 1 (2022): 124–34. http://dx.doi.org/10.21146/2074-4870-2022-22-1-124-134.

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The article analyses the moral justification of human germline editing and the tendency to its legalization. The study is based on documents of international organizations, such as the World Health Organization (WHO), national bioethics committees and others that regulate the usage of technologies for human germline editing or issue related recommendations. The paper analyzes the impact of the introduction of new technologies on human germline editing recommendations. It is concluded that that the development of biotechnologies contributes to liberal attitude towards human germline editing,

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Ryu, Junghyun, Eli Y. Adashi, and Jon D. Hennebold. "The History, Use, and Challenges of Therapeutic Somatic Cell and Germline Gene Editing." Obstetrical & Gynecological Survey 79, no. 3 (2024): 143–45. http://dx.doi.org/10.1097/01.ogx.0001010424.79207.9c.

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ABSTRACT Gene editing is a technology that has been rapidly developing and that has many applications as well as ethical and practical implications. This article is a review that outlines the history of current technology, as well as the advantages and challenges in use for somatic cell and germline gene editing. Clustered regularly interspaced short palindromic repeat (CRISPR) was first introduced in 2002 and initially saw limited use among researchers. However, in 2012, it was discovered that a nuclease associated with CRISPR (Cas9) could be used with guide RNA to cleave double-stranded DNA

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Cwik, Bryan. "Designing Ethical Trials of Germline Gene Editing." New England Journal of Medicine 377, no. 20 (2017): 1911–13. http://dx.doi.org/10.1056/nejmp1711000.

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Sharma, Akshay, Nickhill Bhakta, and Liza-Marie Johnson. "Germline Gene Editing for Sickle Cell Disease." American Journal of Bioethics 20, no. 8 (2020): 46–49. http://dx.doi.org/10.1080/15265161.2020.1781970.

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Koplin, Julian J., Christopher Gyngell, and Julian Savulescu. "Germline gene editing and the precautionary principle." Bioethics 34, no. 1 (2019): 49–59. http://dx.doi.org/10.1111/bioe.12609.

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Padmanabhan, P. "The Ethical Aspects of Germline Gene Editing." Global Bioethics Enquiry Journal 11, no. 1 (2023): 5–11. http://dx.doi.org/10.38020/gbe.11.1.2023.5-11.

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Tan, Zi Ying, Taosheng Huang, and Joanne Ngeow. "65 YEARS OF THE DOUBLE HELIX: The advancements of gene editing and potential application to hereditary cancer." Endocrine-Related Cancer 25, no. 8 (2018): T141—T158. http://dx.doi.org/10.1530/erc-18-0039.

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Hereditary cancer predisposition syndromes are associated with germline mutations that lead to increased vulnerability for an individual to develop cancers. Such germline mutations in tumour suppressor genes, oncogenes and genes encoding for proteins essential in DNA repair pathways and cell cycle control can cause overall chromosomal instability in the genome and increase risk in developing cancers. Gene correction of these germline mutations to restore normal protein functions is anticipated as a new therapeutic option. This can be achieved through disruption of gain-of-function pathogenic m

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Ssebunnya, Gerald Michael. "Towards an appropriate African framework for public engagement with human genome editing: a call to synergistic action." Wellcome Open Research 7 (December 12, 2022): 302. http://dx.doi.org/10.12688/wellcomeopenres.18579.1.

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The CRISPR-Cas9 system has revolutionised the biotechnology of human genome editing. Human germline gene editing promises exponential benefits to many in Africa and elsewhere, especially those affected by the highly prevalent monogenic disorders - for which, thanks to CRISPR, a relatively safe heritable radical therapy is now possible. Africa evidently presents a unique opportunity for empirical research in human germline gene editing because of its high prevalence of monogenic disorders. Critically, however, germline gene editing has raised serious ethical concerns especially because of the s

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Ssebunnya, Gerald Michael. "Towards an appropriate African framework for public engagement with human genome editing: a call to synergistic action." Wellcome Open Research 7 (May 12, 2023): 302. http://dx.doi.org/10.12688/wellcomeopenres.18579.2.

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The CRISPR-Cas9 system has revolutionised the biotechnology of human genome editing. Human germline gene editing promises exponential benefits to many in Africa and elsewhere, especially those affected by the highly prevalent monogenic disorders - for which, thanks to CRISPR, a relatively safe heritable radical therapy is a real possibility. Africa evidently presents a unique opportunity for empirical research in human germline gene editing because of its high prevalence of monogenic disorders. Critically, however, germline gene editing has raised serious ethical concerns especially because of

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Gloria, Nataly Pérez Serrano, and Jeraldine Gonzalez Barajas Alejandra. "Gene Editing in Cancer Therapy." International Journal Of Medical Science And Clinical Research Studies 02, no. 10 (2022): 1120–22. https://doi.org/10.5281/zenodo.7248771.

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The site-specific modification of an existing gene is known as gene editing. A section of DNA must be cut with an endonuclease (such as the CRISPR-Cas9 system) before the two severed ends are brought together, frequently with a new or improved sequence inserted between them. Somatic cell gene editing can be helpful in a variety of clinical contexts, and some preliminary preclinical and clinical trials have been carried out. Extremely high levels of precision are required for DNA recognition, excision, and repair; issues with publishing integrity must be resolved. Germline editing utilizing egg

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Monckton, Darren G. "Manage risk of accidental gene editing of germline." Nature 568, no. 7753 (2019): 458. http://dx.doi.org/10.1038/d41586-019-01284-6.

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Doudna, Jennifer. "CRISPR and Gene Editing: Ethical and Scientific Perspectives." International Journal of Innovative Computer Science and IT Research 1, no. 01 (2025): 1–5. https://doi.org/10.63665/ijicsitr.v1i01.05.

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CRISPR-Cas9 has emerged as one of the most transformative tools in genetic engineering, enabling scientists to perform precise, efficient, and cost-effective gene modifications. This revolutionary gene-editing technology has broad applications in medicine, agriculture, and biotechnology, offering solutions to previously untreatable genetic disorders, enhancing crop resilience, and advancing synthetic biology. In medicine, CRISPR is being explored for treating hereditary diseases, cancer, and infectious diseases, while in agriculture, it is being used to develop disease-resistant crops, improve

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Kühn, Ralf. "Genome engineering in rodents – status quo and perspectives." Laboratory Animals 56, no. 1 (2021): 83–87. http://dx.doi.org/10.1177/00236772211051842.

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The introduction of the CRISPR-Cas9 system in 2013 has revolutionized experimental genetics in mice and rats. This commentary gives an overview on the use of CRISPR either for gene editing in the germline or for editing and beyond editing in somatic cells. Future perspectives are opened by emerging CRISPR technologies that could enable genome engineering at larger scale.

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Charo, R. Alta. "Germline Engineering and Human Rights." AJIL Unbound 112 (2018): 344–49. http://dx.doi.org/10.1017/aju.2018.88.

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With the ever-increasing range of medical technologies at our disposal to mediate the processes of life, from conception to death, comes an ever-increasing number of decision points about human control of fate. And as we debate altering our fate—whether dictated by a deity or by chance—the discussion frequently devolves into a question of whether we may alter not only our own fate, but also that of our children. The advent of genome editing, whether by older methods or the newer, often more easily used methods employing CRISPR, has only made debating the controversial possibility of heritable

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Malmqvist, Erik. "Clinical trials of germline gene editing: The exploitation problem." Bioethics 35, no. 7 (2021): 688–95. http://dx.doi.org/10.1111/bioe.12903.

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de Melo-Martin, Inmaculada. "Germline Gene Editing: Minding the Past and the Future." American Journal of Bioethics 20, no. 8 (2020): 36–38. http://dx.doi.org/10.1080/15265161.2020.1782521.

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de Wert, Guido, Guido Pennings, Angus Clarke, et al. "Human germline gene editing: Recommendations of ESHG and ESHRE." European Journal of Human Genetics 26, no. 4 (2018): 445–49. http://dx.doi.org/10.1038/s41431-017-0076-0.

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Lyon, Jeff. "Bioethics Panels Open Door Slightly to Germline Gene Editing." JAMA 318, no. 17 (2017): 1639. http://dx.doi.org/10.1001/jama.2017.13962.

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Lantos, John D. "Hopes, Fears, and Deja Vu Regarding Germline Gene Editing." JAMA Pediatrics 173, no. 5 (2019): 411. http://dx.doi.org/10.1001/jamapediatrics.2019.0098.

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Kansal, Rina. "The CRISPR-Cas System and Clinical Applications of CRISPR-Based Gene Editing in Hematology with a Focus on Inherited Germline Predisposition to Hematologic Malignancies." Genes 15, no. 7 (2024): 863. http://dx.doi.org/10.3390/genes15070863.

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Clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing has begun to transform the treatment landscape of genetic diseases. The history of the discovery of CRISPR/CRISPR-associated (Cas) proteins/single-guide RNA (sgRNA)-based gene editing since the first report of repetitive sequences of unknown significance in 1987 is fascinating, highly instructive, and inspiring for future advances in medicine. The recent approval of CRISPR-Cas9-based gene therapy to treat patients with severe sickle cell anemia and transfusion-dependent β thalassemia has renewed hope for trea

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Schwartz, Matthew L., M. Wayne Davis, Matthew S. Rich, and Erik M. Jorgensen. "High-efficiency CRISPR gene editing in C. elegans using Cas9 integrated into the genome." PLOS Genetics 17, no. 11 (2021): e1009755. http://dx.doi.org/10.1371/journal.pgen.1009755.

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Gene editing in C. elegans using plasmid-based CRISPR reagents requires microinjection of many animals to produce a single edit. Germline silencing of plasmid-borne Cas9 is a major cause of inefficient editing. Here, we present a set of C. elegans strains that constitutively express Cas9 in the germline from an integrated transgene. These strains markedly improve the success rate for plasmid-based CRISPR edits. For simple, short homology arm GFP insertions, 50–100% of injected animals typically produce edited progeny, depending on the target locus. Template-guided editing from an extrachromoso

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Beriain, Iñigo de Miguel, Emilio Armaza Armaza, and Aliuska Duardo Sánchez. "Human germline editing is not prohibited by the Oviedo Convention: An argument." Medical Law International 19, no. 2-3 (2019): 226–32. http://dx.doi.org/10.1177/0968533219862590.

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Human germline gene editing has ignited wide-ranging debates on the ethical and legal issues involved. The text of the Oviedo Convention is particularly relevant here, as it remains the only international legally binding instrument on the protection of human rights in the biomedical field which considers human genome modification. However, it is often misinterpreted. Indeed, most of the academic literature assumes that Article 13 forbids germline gene editing. This article seeks to demonstrate that this belief is mistaken. To this purpose, it develops a general analysis of the Convention, its

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CWIK, BRYAN. "Moving Beyond ‘Therapy’ and ‘Enhancement’ in the Ethics of Gene Editing." Cambridge Quarterly of Healthcare Ethics 28, no. 04 (2019): 695–707. http://dx.doi.org/10.1017/s0963180119000641.

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Abstract:Since the advent of recombinant DNA technology, expectations (and trepidations) about the potential for altering genes and controlling our biology at the fundamental level have been sky high. These expectations have gone largely unfulfilled. But though the dream (or nightmare) of being able to control our biology is still far off, gene editing research has made enormous strides toward potential clinical use. This paper argues that when it comes to determining permissible uses of gene editing in one important medical context—germline intervention in reproductive medicine—issues about e

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Nordgren, Anders. "Designing Preclinical Studies in Germline Gene Editing: Scientific and Ethical Aspects." Journal of Bioethical Inquiry 16, no. 4 (2019): 559–70. http://dx.doi.org/10.1007/s11673-019-09947-9.

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AbstractHuman germline gene editing is often debated in hypothetical terms: if it were safe and efficient, on what further conditions would it then be ethically acceptable? This paper takes another course. The key question is: how can scientists reduce uncertainty about safety and efficiency to a level that may justify initiation of first-time clinical trials? The only way to proceed is by well-designed preclinical studies. However, what kinds of investigation should preclinical studies include and what specific conditions should they satisfy in order to be considered well-designed? It is argu

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Johnston, Josephine. "Budgets versus Bans: How U.S. Law Restricts Germline Gene Editing." Hastings Center Report 50, no. 2 (2020): 4–5. http://dx.doi.org/10.1002/hast.1094.

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Kim, Young-Min, Seung-Je Woo, and Jae-Yong Han. "Strategies for the Generation of Gene Modified Avian Models: Advancement in Avian Germline Transmission, Genome Editing, and Applications." Genes 14, no. 4 (2023): 899. http://dx.doi.org/10.3390/genes14040899.

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Avian models are valuable for studies of development and reproduction and have important implications for food production. Rapid advances in genome-editing technologies have enabled the establishment of avian species as unique agricultural, industrial, disease-resistant, and pharmaceutical models. The direct introduction of genome-editing tools, such as the clustered regularly interspaced short palindromic repeats (CRISPR) system, into early embryos has been achieved in various animal taxa. However, in birds, the introduction of the CRISPR system into primordial germ cells (PGCs), a germline-c

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Jennifer, Doudna. "CRISPR and Gene Editing: Ethical and Scientific Perspectives." International Journal of Innovative Computer Science and IT Research 01, no. 01 (2025): 29–33. https://doi.org/10.5281/zenodo.15152043.

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CRISPR-Cas9 has emerged as one of the most transformative tools in genetic engineering, enabling scientists to perform precise, efficient, and cost-effective gene modifications. This revolutionary gene-editing technology has broad applications in medicine, agriculture, and biotechnology, offering solutions to previously untreatable genetic disorders, enhancing crop resilience, and advancing synthetic biology. In medicine, CRISPR is being explored for treating hereditary diseases, cancer, and infectious diseases, while in agriculture, it is being used to develop di

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Annas, George J. "Genome Editing 2020: Ethics and Human Rights in Germline Editing in Humans and Gene Drives in Mosquitoes." American Journal of Law & Medicine 46, no. 2-3 (2020): 143–65. http://dx.doi.org/10.1177/0098858820933492.

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The moon landing, now more than a half century in the past, has turned out to be the culmination of human space travel, rather than its beginning. Genetic engineering, especially applications of CRISPR, now presents the most publicly-discussed engineering challenges—and not just technical, but ethical as well. In this article, I will use the two most controversial genomic engineering applications to help identify the ethics and human rights implications of these research projects. Each of these techniques directly modifies the mechanisms of evolution, threatens to alter our views of ourselves

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Krzyzanowski, Damian, Sushree S. Sahoo, Lili Kotmayer, et al. "Systematic Mapping of Gene-Editable Mutations in GATA2 and SAMD9/SAMD9L Syndromes." Blood 142, Supplement 1 (2023): 1362. http://dx.doi.org/10.1182/blood-2023-190982.

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Germline predisposition to bone marrow failure (BMF) and myelodysplastic syndromes (MDS) cause substantial economic and psychosocial burden and early mortality in affected individuals. Due to the limitations and risks of hematopoietic stem cell transplantation, there is an urgent need for new and innovative treatment approaches. Conventional lentiviral-based gene therapy is not feasible for most BMF/MDS predisposing genes because their uncontrolled overexpression is detrimental and lentiviral vectors might cause insertional mutagenesis. However, new technologies that precisely modify the endog

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Yasmeen, ., and Vaishnavi Thota. "Crispr Chronicles: Pioneering Gene Editing in Cardiovascular Therapy." International Journal of Current Science Research and Review 08, no. 04 (2025): 1676–81. https://doi.org/10.5281/zenodo.15197860.

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Abstract : CRISPR-Cas systems have revolutionized gene editing, offering precise and efficient genome modifications with vast applications in biomedical research and therapeutic interventions. This technology has surpassed traditional methods such as zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) due to its simplicity, cost-effectiveness, and high accuracy. In cardiovascular disease (CVD) research, CRISPR has been instrumental in generating precise disease models, identifying genetic risk factors, and developing potential therapeutic strategies. Genom

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Reddy Banavasi, Vinod Kumar. "Gene Editing: The Revolution of CRISPR Technology"." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 344–48. https://doi.org/10.35629/4494-1002344348.

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CRISPR-Cas9 has revolutionized genetic engineering by enabling precise, efficient, and programmable gene editing. Originally derived from a bacterial immune defense system, this technology utilizes a guide RNA (gRNA) to direct the Cas9 nuclease to a specific DNA sequence, where it induces a targeted double-strand break. The subsequent repair is mediated by either nonhomologous end joining (NHEJ), which introduces insertions or deletions, or homology-directed repair (HDR), allowing precise genetic modifications. CRISPR-Cas9 has widespread applications in medicine, agriculture, and biotechnology

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Hurlbut, J. Benjamin. "The Demands of CRISPR’s World." Ethics & Medics 41, no. 4 (2016): 1–2. http://dx.doi.org/10.5840/em20164146.

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A growing chorus of voices is declaring that CRISPR will revolutionize the ability to control life, including human life. As genetically altering future generations becomes technically realistic, it raises the prospect of genetic enhancement and the specter of eugenics. Prominent scientists are calling for international guidelines to govern human applications of gene-editing technology. They argue that the technical possibility of human germline gene editing makes ethical deliberation urgent. Now that the technology is upon us, the time has come to ask whether we want it. Human germline geneti

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Coller, Barry S. "Ethics of Human Genome Editing." Annual Review of Medicine 70, no. 1 (2019): 289–305. http://dx.doi.org/10.1146/annurev-med-112717-094629.

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Advances in human genome editing, in particular the development of the clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 method, have led to increasing concerns about the ethics of editing the human genome. In response, the US National Academy of Sciences and the National Academy of Medicine constituted a multidisciplinary, international committee to review the current status and make recommendations. I was a member of that committee, and the core of this review reflects the committee's conclusions. The committee's report, issued in February 2017, recommends the application of

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Vaishnavi, Bhad Gaurav Bhalerao Rani Deokar*. "CRISPR-CAS 9 In Gene Editing: Innovations, Applications and Ethical Challenges." International Journal of Scientific Research and Technology 1, no. 11 (2024): 59–71. https://doi.org/10.5281/zenodo.14161891.

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CRISPR-Cas9 has emerged as a revolutionary tool in gene editing, enabling precise alterations in the DNA sequence with unprecedented accuracy and efficiency. This technology leverages the natural defense mechanism of bacteria against viruses, allowing researchers to target specific genes for modification, deletion, or insertion. The potential applications of CRISPR-Cas9 are vast, ranging from therapeutic interventions for genetic disorders, cancer treatment, and viral infections to advancements in agriculture and biotechnology. Despite its promise, CRISPR-Cas9 raises significant ethical concer

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Zhang, Di, and Reidar K. Lie. "Ethical issues in human germline gene editing: a perspective from China." Monash Bioethics Review 36, no. 1-4 (2018): 23–35. http://dx.doi.org/10.1007/s40592-018-0091-0.

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Hall, Jeanatan. "The Ethics of Human Tripronuclear Zygotes as Germline Editing Subjects." National Catholic Bioethics Quarterly 19, no. 3 (2019): 429–42. http://dx.doi.org/10.5840/ncbq201919332.

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Despite great interest in the field of gene editing, sparked by the advent of CRISPR/Cas9-mediated applications, the personhood of tripronuclear zygotes has not been addressed appropriately. 3PN zygotes are discarded as medical waste, and their use as models for human genome editing is becoming increasing common. 3PN zygotes possess an extra set of chromosomes, which often leads to severe genetic abnormalities; they are dismissed as “nonviable embryos” and treated as an ethically acceptable alternative to human embryonic research. However, given the development cycle of 3PN zygotes and the qua

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Evans, John H. "Setting ethical limits on human gene editing after the fall of the somatic/germline barrier." Proceedings of the National Academy of Sciences 118, no. 22 (2021): e2004837117. http://dx.doi.org/10.1073/pnas.2004837117.

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The ethical debate about what is now called human gene editing (HGE) has gone on for more than 50 y. For nearly that entire time, there has been consensus that a moral divide exists between somatic and germline HGE. Conceptualizing this divide as a barrier on a slippery slope, in this paper, I first describe the slope, what makes it slippery, and describe strong barriers that arrest the slippage down to the dystopian bottom of pervasive eugenic enhancement. I then show how the somatic/germline barrier in the debate has been weakened to the level of ineffectiveness, with no replacement below. I

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Nakamura, Shingo, Kazunori Morohoshi, Emi Inada, et al. "Recent Advances in In Vivo Somatic Cell Gene Modification in Newborn Pups." International Journal of Molecular Sciences 24, no. 20 (2023): 15301. http://dx.doi.org/10.3390/ijms242015301.

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Germline manipulation at the zygote stage using the CRISPR/Cas9 system has been extensively employed for creating genetically modified animals and maintaining established lines. However, this approach requires a long and laborious task. Recently, many researchers have attempted to overcome these limitations by generating somatic mutations in the adult stage through tail vein injection or local administration of CRISPR reagents, as a new strategy called “in vivo somatic cell genome editing”. This approach does not require manipulation of early embryos or strain maintenance, and it can test the

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Bi, Honglun, Xia Xu, Xiaowei Li, et al. "CRISPR Disruption of BmOvo Resulted in the Failure of Emergence and Affected the Wing and Gonad Development in the Silkworm Bombyx mori." Insects 10, no. 8 (2019): 254. http://dx.doi.org/10.3390/insects10080254.

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The domesticated silkworm is an economically important insect that is widely used as a lepidopteran insect model. Although somatic sex determination in the silkworm is well characterized, germline sex determination is not. Here, we used the transgenic-based CRISPR/Cas9 genome editing system to study the function of the Ovo gene in Bombyx mori. BmOvo is the homolog of a factor important in germline sex determination in Drosophila melanogaster. BmOvo mutants had abnormally shaped eggs that were disordered in the ovarioles, and gonad development was abnormal. Interestingly, wing discs and wings d

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Sutton, Agneta. "Editing della linea germinale: quali sono i rischi sociali e morali? / Germ-line gene editing: What are the social and moral risks?" Medicina e Morale 65, no. 2 (2016): 123–30. http://dx.doi.org/10.4081/mem.2016.430.

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Dovremmo accogliere tutti i possibili sviluppi dell’editing genetico? L’editing genetico delle cellule somatiche potrebbe essere considerato alla pari delle terapie convenzionali volte a trattare particolari patologie o ad alleviarne i sintomi. Tale intervento interesserebbe esclusivamente il singolo paziente trattato. Esso potrebbe quindi essere ben accolto come un nuovo tipo di trattamento per i tumori e le malattie del sangue, come ad esempio la beta-talassemia. Diversamente, l’editing della linea germinale avrebbe effetti ereditari. Ciò solleva preoccupazioni particolari riguardo al rischi

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Cussins, Jessica, and Leah Lowthorp. "Germline Modification and Policymaking: The Relationship between Mitochondrial Replacement and Gene Editing." New Bioethics 24, no. 1 (2018): 74–94. http://dx.doi.org/10.1080/20502877.2018.1443409.

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Johnston, Josephine. "Shaping the CRISPR Gene-Editing Debate: Questions About Enhancement and Germline Modification." Perspectives in Biology and Medicine 63, no. 1 (2020): 141–54. http://dx.doi.org/10.1353/pbm.2020.0011.

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