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Littérature scientifique sur le sujet « Globin switching »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "Globin switching"

Ikuta, Tohru, Thalia Papayannopoulou, George Stamatoyannopoulos, and Yuet Wai Kan. "Globin Gene Switching." Journal of Biological Chemistry 271, no. 24 (1996): 14082–91. http://dx.doi.org/10.1074/jbc.271.24.14082.

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Wood, WG. "Haemoglobin Switching." Physiology 3, no. 1 (1988): 33–35. http://dx.doi.org/10.1152/physiologyonline.1988.3.1.33.

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Haemoglobin switching involves changes in production of the globin chains at specific times during vertebrate development. The hereditary haemolytic anaemias known as thalassaemias, which result from decreased or no synthesis of one of the globins, are some of the most common genetic diseases of humans.

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Kingsley, Paul D., Jeffrey Malik, Rachel L. Emerson, et al. "“Maturational” globin switching in primary primitive erythroid cells." Blood 107, no. 4 (2006): 1665–72. http://dx.doi.org/10.1182/blood-2005-08-3097.

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Mammals have 2 distinct erythroid lineages. The primitive erythroid lineage originates in the yolk sac and generates a cohort of large erythroblasts that terminally differentiate in the bloodstream. The definitive erythroid lineage generates smaller enucleated erythrocytes that become the predominant cell in fetal and postnatal circulation. These lineages also have distinct globin expression patterns. Our studies in primary murine primitive erythroid cells indicate that βH1 is the predominant β-globin transcript in the early yolk sac. Thus, unlike the human, murine β-globin genes are not up-re

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Perrine, Susan P. "Switching globin, raising red cells." Blood 118, no. 4 (2011): 834–36. http://dx.doi.org/10.1182/blood-2011-06-354373.

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Johnson, Robert M., Deborah Gumucio, and Morris Goodman. "Globin gene switching in primates." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 133, no. 3 (2002): 877–83. http://dx.doi.org/10.1016/s1095-6433(02)00205-2.

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Hsia, Nelson, Jennifer L. Axe, Noelle Paffett-Lugassy, Yi Zhou, and Leonard I. Zon. "Globin switching in the zebrafish." Blood Cells, Molecules, and Diseases 38, no. 2 (2007): 145. http://dx.doi.org/10.1016/j.bcmd.2006.10.062.

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Roberts, N. A., J. A. Sloane-Stanley, J. A. Sharpe, S. J. Stanworth, and W. G. Wood. "Globin Gene Switching in Transgenic Mice Carrying HS2-Globin Gene Constructs." Blood 89, no. 2 (1997): 713–23. http://dx.doi.org/10.1182/blood.v89.2.713.

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Abstract We have examined the pattern of human globin gene switching in transgenic mice containing three different γ and β gene constructs (HS2GγAγδβ, HS2Aγβneo, and HS2Aγenβ) and compared the results with previously described transgenics (HS2Aγβ, HS2GγAγ-117δβ, and LCRεGγAγδβ). Developmental regulation was observed in all cases with identical patterns in lines bearing the same construct. Three different patterns of switching were observed: LCRεGγAγδβ and HS2Aγβneo mice switched rapidly, HS2GγAγδβ and HS2GγAγ-117δβ at an intermediate rate, and HS2Aγβ and HS2Aγenβ mice showed delayed switching,

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Palis, James, Jeff Malik, Rachael L. Emerson, et al. "“Maturational” Globin Switching in Primary Primitive Erythroid Cells." Blood 106, no. 11 (2005): 3634. http://dx.doi.org/10.1182/blood.v106.11.3634.3634.

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Abstract Mammals have two distinct erythroid lineages. The “definitive” erythroid lineage generates small, enucleated erythrocytes that constitute the predominant cell type in the fetal and postnatal circulation. It is preceded by the “primitive” erythroid lineage, which originates in the yolk sac and generates a semi-synchronous wave of large erythroblasts that terminally differentiate in the bloodstream. This feature provides a unique opportunity to investigate changes in gene expression during erythroid maturation. Here, we have examined expression of the various α- and β-globin genes in pu

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Chan, Fung-Yee, Judith Robinson, Alison Brownlie та ін. "Characterization of Adult α- and β-Globin Genes in the Zebrafish". Blood 89, № 2 (1997): 688–700. http://dx.doi.org/10.1182/blood.v89.2.688.

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Abstract Developmental switching of hemoglobins (Hbs) occurs in most vertebrates, yet the cellular and molecular basis for this process remains elusive. The zebrafish is a new genetic and developmental system that can be used to study embryogenesis, and mutants with a variety of defects in hematopoiesis have recently been derived. To initiate our studies on Hb switching in this organism, we have characterized the globins expressed in the adult. Reversed-phase high performance liquid chromatography and mass spectrometric analyses of adult peripheral blood hemolysates showed that there are three

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Xu, Jian, Vijay G. Sankaran, Yuko Fujiwara, and Stuart H. Orkin. "Control of Hemoglobin Switching by BCL11A." Blood 114, no. 22 (2009): 5. http://dx.doi.org/10.1182/blood.v114.22.5.5.

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Abstract Abstract 5 All vertebrates switch expression of globin chains during development. In humans b-like globins switch from embryonic to fetal to adult, whereas in the mouse a single switch from embryonic to adult occurs. The switch from human fetal (g) to adult (b) expression is especially critical in the b-hemoglobin disorders, such as sickle cell anemia and the b-thalassemias. Delay of the switch or reactivation of the fetal gene in the adult stage greatly ameliorates clinical severity. Despite intensive molecular studies of the human b-globin cluster over more than two decades, the pro

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Thèses sur le sujet "Globin switching"

Ganis, Jared Jason. "Regulators of hemoglobin switching in zebrafish and human models." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11391.

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Hemoglobin switching is a developmental process involving the dynamic transcriptional regulation of multiple globin genes. This molecular process involves multiple layer of complexity, and elucidating new mechanisms in this process will result in a more complete understanding of general gene regulation and will likely have direct clinical implications for hemoglobinopathies, such as sickle cell anemia. In this dissertation, I develop and characterize a new model for hemoglobin switching, the zebrafish. I defined and fully annotated the two zebrafish globin loci, termed major and minor loci.

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ELANGOVAN, SUDHARSHAN. "Role of Sox6 and Coup-TFII transcription factors in the regulation of hemoglobin switching." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/59018.

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Several transcription factors are essential for erythroid commitment and for differential globin gene expression during development. Sox6 and COUP-TFII are important Transcription Factors that are known to be modulators of globins genes regulation. By using a variant erythroleukemic cell line (V-K562) expressing both γ- and β- globins, we show how Sox6 and COUP-TFII are able to differentially regulate fetal versus adult globin genes. Both Sox6 and COUP-TFII binds in vitro and in vivo to the γ-globin promoter. Lentiviral mediated overexpression of Sox6 in this variant cells predominantly increa

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Amaya, Maria. "The Role of the Nucleosome Remodeling and Histone Deacetylase (NuRD) Complex in Fetal γ-Globin Expression". VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/521.

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An understanding of the human fetal to adult hemoglobin switch offers the potential to ameliorate β-type globin gene disorders such as sickle cell anemia and β-thalassemia through activation of the fetal γ-globin gene. Chromatin modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD play a role in γ-globin gene silencing, and Mi2β (CHD4) is a critical component of NuRD complexes. In the studies presented in Chapter 2, we observed that the absence of MBD2 in a sickle cell mouse model leads to a decrease in the number of sickled cells observed in the peripheral blood, and significantly i

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Kim, Kicheon. "QoS supporting mechanisms for a global packet switching network." Thesis, Lancaster University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387467.

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Emery, Martin Banking &amp Finance Australian School of Business UNSW. "Studies into global asset allocation strategies using the markov-switching model." Publisher:University of New South Wales. Banking & Finance, 2008. http://handle.unsw.edu.au/1959.4/43098.

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This thesis presents the potential opportunities of global asset allocation and the possible enhancement of these opportunities from using a Markov Switching Model. The thesis extends upon previous conditional asset pricing studies in global asset allocation, such as those done by Ilamnen (1995), Harvey, Solnik and Zhou (1992) and Bilson (1993), where expected future returns are forecast based on conditional variables. The finding of these studies, and many others, are combined with the works on Markov Switching models and market segmentation theories to create a uniform structure for analys

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Hubbard, Jason. "The Dynamics of Global States in Executive Control." Thesis, University of Oregon, 2017. http://hdl.handle.net/1794/22632.

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In the present work, we examine how the cognitive system responds to complex environments. It has been proposed that executive control, which is responsible for orchestrating high-level behavior in such environments, operates according to different broad processing modes, one geared towards stability and focus (“maintenance”), and the other that’s open to environmental influence (“updating”). Aging work has proposed that this latter mode is over-represented in older age, leading to deficits in many, but not all cognitive domains. Across three studies, we sought to identify the dynamics of the

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Stokłosa, Michał Jerzy. "Effects of the evolving global tobacco product landscape on smokers' switching behaviors." Doctoral thesis, Faculty of Commerce, 2019. http://hdl.handle.net/11427/31275.

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How effectively governments can use tobacco tax as a public health and a revenue-generating measure depends on how able smokers are to circumvent the tax by switching to other tobacco products. Recently, tobacco product switching has become more common, especially with many new tobacco product types appearing on the market. The research on these switching behaviors is scarce. This thesis provides analysis in three aspects tobacco product switching: (1) price-driven between-product substitution, (2) switching to newly-introduced tobacco products and (3) switching to products on which no domesti

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Andersson, Sebastian. "On the Specification of Local Models in a Global Vector Autoregression: A Comparison of Markov-Switching Alternatives." Thesis, Uppsala universitet, Statistiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-226918.

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In this paper, focus is on the global vector autoregressive (GVAR) model. Its attractiveness stems from an ability to incorporate global interdependencies when modeling local economies. The model is based on a collection of local models, which in general are estimated as regular VAR models. This paper examines alternative specifications of the local models by estimating them as regime-switching VAR models, where transition probabilities between different states are studied using both constant and time-varying settings. The results show that regime-switching models are appealing as they yield i

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Riccardi, William III. "An Empirical Analysis of the Global Audit Market: International Financial Reporting Standards-Related Changes and Differences within the Big 4 Global Networks." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1440.

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Ongoing debates within the professional and academic communities have raised a number of questions specific to the international audit market. This dissertation consists of three related essays that address such issues. First, I examine whether the propensity to switch between auditors of different sizes (i.e., Big 4 versus non-Big 4) changes as adoption of International Financial Reporting Standards (IFRS) becomes a more common phenomenon, arguing that smaller auditors have an opportunity to invest in necessary skills and training needed to enter this market. Findings suggest that clients are

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Klein, Matthew. "Cap and trade or a carbon tax? how to reduce CO₂ emissions /." Diss., Connect to the thesis, 2009. http://hdl.handle.net/10066/3808.

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Livres sur le sujet "Globin switching"

George, Stamatoyannopoulos, Nienhuis Arthur W, and Conference on Hemoglobin Switching (7th : 1990 : Airlie, Va.), eds. The Regulation of hemoglobin switching. Johns Hopkins University Press, 1991.

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George, Stamatoyannopoulos, and Nienhuis Arthur W, eds. Hemoglobin switching: Proceedings of the Sixth Conference on Hemoglobin Switching, held in Airlie, Virginia, September 24-27, 1988. A.R. Liss, 1989.

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George, Stamatoyannopoulos, and Nienhuis Arthur W, eds. Developmental control of globin gene expression: Proceedings of the Fifth Conference on Hemoglobin Switching, held in Airlie, Virginia, September 28-October 1, 1986. Liss, 1987.

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P, Banks Stephen. Global stabilization of nonlinear systems via switching manifolds. University of Sheffield, Dept. of Automatic Control and Systems Engineering, 1996.

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Yŏnʼguwŏn, Hanʼguk Chŏnja Tʻongsin, та Korea (South) Chŏngbo Tʻongsinbu, ред. 4-sedae idong tʻongsin kisul kaebal chung 4-sedae idong tʻongsin pʻaekʻit musŏn chŏnsong kisul yŏnʼgu =: Research on packet transmission technology for 4th generation mobile communication. Chŏngbo Tʻongsinbu, 2005.

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Bovair, Jennifer L. Alternative transportation fuels and vehicle technologies: Challenges and opportunities : a report of the CSIS Energy and National Security Program, CSIS Global Strategy Institute, and National Renewable Energy Laboratory. Center for Strategic and International Studies, 2008.

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Hemoglobin switching: Proceedings of the Sixth Conference on Hemoglobin Switching, held in Airlie, Virginia, September 24-27, 1988 (Progress in clinical and biological research). A.R. Liss, 1989.

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Stomatoyannopoulos, George, and Arthur W. Nienhuis. Hemoglobin Switching, Part A: Transcriptional Regulation: Proceedings of the Sixth Conference on Hemoglobin Switching Held in Airlie, Virginia, sept. Wiley-Liss, 1989.

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Nienhuis, Arthur W., and George Stomatoyannpoulos. Hemoglobin Switching, Part B: Cellular and Molecular Mechanisms (Progress in Clinical and Biological Research, Vol 316B). Wiley-Liss, 1989.

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Developmental control of globin gene expression: Proceedings of the Fifth Conference on Hemoglobin Switching, held in Airlie, Virginia, September 28-October ... in clinical and biological research). Liss, 1987.

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Chapitres de livres sur le sujet "Globin switching"

Grosveld, F., M. Antoniou, M. Berry, et al. "The regulation of human globin gene switching." In Transgenic Modification of Germline and Somatic Cells. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1240-6_6.

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Perrine, Susan P., Paul Swerdlow, Douglas V. Faller, et al. "Butyric Acid Modulates Developmental Globin Gene Switching in Man and Sheep." In Advances in Experimental Medicine and Biology. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0623-8_18.

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Moriarty, Patrick, and Damon Honnery. "Introduction to Global Energy Challenges." In Switching Off. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-0767-8_1.

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Zhu, Chaoyuan. "Global Nonadiabatic Switching Algorithm." In Challenges and Advances in Computational Chemistry and Physics. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-4296-7_6.

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Chan, Ka Long Roy. "Code-Switching in Hong Kong." In Teaching English Language Variation in the Global Classroom. Routledge, 2021. http://dx.doi.org/10.4324/9781003124665-17.

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Kardo-Sysoev, Alexei F. "Global Limitation on Fast Switching by Semiconductor Devices." In Ultra-Wideband Short-Pulse Electromagnetics 8. Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-73046-2_31.

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Krolzig, Hans-Martin. "Markov-Switching Models of Global and International Business Cycles." In Lecture Notes in Economics and Mathematical Systems. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-51684-9_13.

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Whitten, Dwayne. "Adaptability in IT Sourcing: The Impact of Switching Costs." In Global Sourcing of Information Technology and Business Processes. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-15417-1_11.

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Park, Dohyun, In-Bum Chung, and Dong-Hoon Choi. "Surrogate Based Global Optimization Using Adaptive Switching Infill Sampling Criterion." In Advances in Structural and Multidisciplinary Optimization. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-67988-4_52.

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Liu, Zixin. "Cognitive impacts of language switching among bilingual individuals." In Global Dialogue on Media Dynamics, Trends and Perspectives on Public Relations and Communication. CRC Press, 2024. https://doi.org/10.1201/9781003564966-79.

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Actes de conférences sur le sujet "Globin switching"

Sciatti, Francesco, Paolo Tamburrano, Andrew R. Plummer, Elia Distaso, Pietro De Palma, and Riccardo Amirante. "Numerical Simulations of a High Frequency Switching 4/2 ON/OFF Valve for Pulse Modulation Switching Digital Circuits." In 2022 Global Fluid Power Society Ph.D. Symposium. River Publishers, 2024. http://dx.doi.org/10.13052/rp-9788770047975.015.

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Tscherniewski, Julia, and Stefan Butzmann. "Powertrain Improvement by Adjustment of Inverter Switching Frequency." In 2025 7th Global Power, Energy and Communication Conference (GPECOM). IEEE, 2025. https://doi.org/10.1109/gpecom65896.2025.11061864.

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Shang, Keyuan, Shengbo Liu, Jianhua Tang, Xiang Cheng, Wen Wu, and Liang Song. "Joint Slice Switching and Resource Allocation for Energy-Efficient Network Slicing." In GLOBECOM 2024 - 2024 IEEE Global Communications Conference. IEEE, 2024. https://doi.org/10.1109/globecom52923.2024.10901429.

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Valtchev, Stanimir, Elena Ivanovna Gracheva, Almaz Radikovich Petrov, Dilyana Gospodinova, Tatyana Sinyukova, and Rosario Miceli. "Assessment of Switching Wear Endurance of Industrial Low Voltage Devices." In 2025 7th Global Power, Energy and Communication Conference (GPECOM). IEEE, 2025. https://doi.org/10.1109/gpecom65896.2025.11061843.

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Fujiwara, M., S. Suzuki, K. Emura, et al. "Optical Switching in Coherent Lightwave Systems." In Photonic Switching. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/phs.1987.tha4.

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Broad-band networks providing various kinds of services, such as video and high speed data communications, have received increasing attention in not only local-area networks(LANs) but also wide-area networks(WANs). Recent progress in optical fiber transmission has already made worldwide point-to-point transmission links possible. Coherent lightwave technology would further make evolution in transmission length and information capacity. Optical switch would be a key technology for achieving all optical broad-band WANs, where switching and routing functions will be accomplished in optical domain

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Psaltis, Demetri. "Optical Neural Computers." In Photonic Switching. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/phs.1987.wb3.

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The development of optical computers of any type is based on the notion that semiconductor technology imposes limitations in the performance of current computers which prevent them from being effectively used for the solution of a class of interesting computational problems. If optics is used instead, these limitations will be lifted and we will therefore be able to now solve these interesting problems. Global connectivity is perhaps the most distinctive feature of optics vis-a-vis semiconductor technology, and the development of optical neural computers can be viewed as an attempt to exploit

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Kogelnik, Herwig. "Photonics Beyond Information Transport?" In Photonics in Switching. Optica Publishing Group, 1995. http://dx.doi.org/10.1364/ps.1995.pwa1.

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Photonics has rapidly become the dominant technology for the transmission of information in the national and global infrastructure, including undersea, terrestrial long-haul, CATV and local telephone access applications. Expanding this success deeper into the network, we are challenged by new requirements such as conforming to the new ATM (asynchronous transfer-mode) standards and by new opportunities such as wavelength routing and transparent high-capacity networking.

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Dumortier, Philip, Thierry Van Landegem, Francesco Masetti, and Michel Sotom. "Telecom Networks Going Photonic: Reconciling Transparency with Scalability." In Photonics in Switching. Optica Publishing Group, 1995. http://dx.doi.org/10.1364/ps.1995.pwd2.

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The introduction of Wavelength Division Multiplexing (WDM) techniques into fiber networks opens perspectives for a global transparent optical telecommunication backbone. One of the most promising features of optical telecommunications is to provide a common infrastructure which could become an integration factor in a heterogenous but interconnected network environment. Furthermore optics can provide a degree of network transparency to bitrate, transfer mode and signal format of the transported signals. By using transparent optical crossconnect nodes, based on space and wavelength routing, a re

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Inoue, Hiroaki, Tatemi Ido, Hirohisa Sano, and Tatsuo Kanetake. "InP-based MQW optical devices for photonic switching." In Photonics in Switching. Optica Publishing Group, 1997. http://dx.doi.org/10.1364/ps.1997.jfa1.

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Increasing demands for high-bit-rate transmission technologies enabling interactive multimedia era reach to establishing the global information infrastructure based upon optical tera-bit/s telecommunication network.1) The optical network, which fully utilizes optical bandwidth of fiber, will exploit the functionality offered not only by TDM(Time Division Multiplexing) but also by WDM(Wavelength Division Multiplexing) technologies. The optical high-bit-rate(TDM) and WDM transmission technologies accompanied by the optical node2) technologies such as WDM-ADM(Add/Drop Multiplexer) and WDM-OXC(Opt

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Wang, Fanggang, and Soung Chang Liew. "Wireless MIMO switching." In GLOBECOM 2012 - 2012 IEEE Global Communications Conference. IEEE, 2012. http://dx.doi.org/10.1109/glocom.2012.6503806.

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Rapports d'organisations sur le sujet "Globin switching"

Yılmaz, Fatih. Understanding the Dynamics of the Renewable Energy Transition: The Determinants and Future Projections Under Different Scenarios. King Abdullah Petroleum Studies and Research Center, 2022. http://dx.doi.org/10.30573/ks--2021-dp25.

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The global energy system’s current structure has severe environmental consequences that necessitate an urgent transformation toward more sustainable alternatives. Besides many available mitigation actions, such as enhancing energy efficiency, deploying nuclear energy, switching fuels and adopting carbon capture technologies, renewable energy (RE) has been the most widely applied one in many countries, especially for the power sector. The average country-level share of non-hydroelectric renewable energy (NhRE) in power generation rose sixfold over the last two decades, from less than 1% in 2000

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Méndez-Vizcaíno, Juan C., and Nicolás Moreno-Arias. A Global Shock with Idiosyncratic Pains: State-Dependent Debt Limits for LATAM during the COVID-19 pandemic. Banco de la República, 2021. http://dx.doi.org/10.32468/be.1175.

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Fiscal sustainability in five of the largest Latin American economies is examined before and after the COVID-19 pandemic. For this purpose, the DSGE model in Bi(2012) and Hürtgen (2020) is used to estimate the Fiscal Limits and Fiscal Spaces for Peru, Chile, Mexico, Colombia, and Brazil. These estimates advance the empirical literature for Latin America on fiscal sustainability by offering new calculations stemming from a structural framework with alluring novel features: government default on the intensive margin; dynamic Laffer curves; utility-based stochastic discount factor; and a Markov-S

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