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Thèses sur le sujet « Globin switching »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Ganis, Jared Jason. "Regulators of hemoglobin switching in zebrafish and human models." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11391.

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Hemoglobin switching is a developmental process involving the dynamic transcriptional regulation of multiple globin genes. This molecular process involves multiple layer of complexity, and elucidating new mechanisms in this process will result in a more complete understanding of general gene regulation and will likely have direct clinical implications for hemoglobinopathies, such as sickle cell anemia. In this dissertation, I develop and characterize a new model for hemoglobin switching, the zebrafish. I defined and fully annotated the two zebrafish globin loci, termed major and minor loci.

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ELANGOVAN, SUDHARSHAN. "Role of Sox6 and Coup-TFII transcription factors in the regulation of hemoglobin switching." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/59018.

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Several transcription factors are essential for erythroid commitment and for differential globin gene expression during development. Sox6 and COUP-TFII are important Transcription Factors that are known to be modulators of globins genes regulation. By using a variant erythroleukemic cell line (V-K562) expressing both γ- and β- globins, we show how Sox6 and COUP-TFII are able to differentially regulate fetal versus adult globin genes. Both Sox6 and COUP-TFII binds in vitro and in vivo to the γ-globin promoter. Lentiviral mediated overexpression of Sox6 in this variant cells predominantly increa

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Amaya, Maria. "The Role of the Nucleosome Remodeling and Histone Deacetylase (NuRD) Complex in Fetal γ-Globin Expression". VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/521.

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An understanding of the human fetal to adult hemoglobin switch offers the potential to ameliorate β-type globin gene disorders such as sickle cell anemia and β-thalassemia through activation of the fetal γ-globin gene. Chromatin modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD play a role in γ-globin gene silencing, and Mi2β (CHD4) is a critical component of NuRD complexes. In the studies presented in Chapter 2, we observed that the absence of MBD2 in a sickle cell mouse model leads to a decrease in the number of sickled cells observed in the peripheral blood, and significantly i

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Kim, Kicheon. "QoS supporting mechanisms for a global packet switching network." Thesis, Lancaster University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387467.

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Emery, Martin Banking &amp Finance Australian School of Business UNSW. "Studies into global asset allocation strategies using the markov-switching model." Publisher:University of New South Wales. Banking & Finance, 2008. http://handle.unsw.edu.au/1959.4/43098.

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This thesis presents the potential opportunities of global asset allocation and the possible enhancement of these opportunities from using a Markov Switching Model. The thesis extends upon previous conditional asset pricing studies in global asset allocation, such as those done by Ilamnen (1995), Harvey, Solnik and Zhou (1992) and Bilson (1993), where expected future returns are forecast based on conditional variables. The finding of these studies, and many others, are combined with the works on Markov Switching models and market segmentation theories to create a uniform structure for analys

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Hubbard, Jason. "The Dynamics of Global States in Executive Control." Thesis, University of Oregon, 2017. http://hdl.handle.net/1794/22632.

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In the present work, we examine how the cognitive system responds to complex environments. It has been proposed that executive control, which is responsible for orchestrating high-level behavior in such environments, operates according to different broad processing modes, one geared towards stability and focus (“maintenance”), and the other that’s open to environmental influence (“updating”). Aging work has proposed that this latter mode is over-represented in older age, leading to deficits in many, but not all cognitive domains. Across three studies, we sought to identify the dynamics of the

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Stokłosa, Michał Jerzy. "Effects of the evolving global tobacco product landscape on smokers' switching behaviors." Doctoral thesis, Faculty of Commerce, 2019. http://hdl.handle.net/11427/31275.

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How effectively governments can use tobacco tax as a public health and a revenue-generating measure depends on how able smokers are to circumvent the tax by switching to other tobacco products. Recently, tobacco product switching has become more common, especially with many new tobacco product types appearing on the market. The research on these switching behaviors is scarce. This thesis provides analysis in three aspects tobacco product switching: (1) price-driven between-product substitution, (2) switching to newly-introduced tobacco products and (3) switching to products on which no domesti

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Andersson, Sebastian. "On the Specification of Local Models in a Global Vector Autoregression: A Comparison of Markov-Switching Alternatives." Thesis, Uppsala universitet, Statistiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-226918.

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In this paper, focus is on the global vector autoregressive (GVAR) model. Its attractiveness stems from an ability to incorporate global interdependencies when modeling local economies. The model is based on a collection of local models, which in general are estimated as regular VAR models. This paper examines alternative specifications of the local models by estimating them as regime-switching VAR models, where transition probabilities between different states are studied using both constant and time-varying settings. The results show that regime-switching models are appealing as they yield i

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Riccardi, William III. "An Empirical Analysis of the Global Audit Market: International Financial Reporting Standards-Related Changes and Differences within the Big 4 Global Networks." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1440.

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Ongoing debates within the professional and academic communities have raised a number of questions specific to the international audit market. This dissertation consists of three related essays that address such issues. First, I examine whether the propensity to switch between auditors of different sizes (i.e., Big 4 versus non-Big 4) changes as adoption of International Financial Reporting Standards (IFRS) becomes a more common phenomenon, arguing that smaller auditors have an opportunity to invest in necessary skills and training needed to enter this market. Findings suggest that clients are

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Klein, Matthew. "Cap and trade or a carbon tax? how to reduce CO₂ emissions /." Diss., Connect to the thesis, 2009. http://hdl.handle.net/10066/3808.

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Siegfried, Frank. "A cross-cultural study of consumer switching in the retail banking services sector." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/a-crosscultural-study-of-consumer-switching-in-the-retail-banking-services-sector(898200e5-15ad-48e5-8e18-77706d4594d4).html.

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The retail banking services sector, a key driver for global economic growth, faces drastic challenges, such as globalised competition and continuously changing customer expectations that call for an in-depth understanding of customer switching, particularly in Asia’s emerging markets. Research shows that minor reductions in switching can notably enhance profitability. Yet only insufficient or fragmented research to explain switching exists. For this study titled “A Cross-Cultural Study of Consumer Switching in the Retail Banking Services Sector” at The University of Manchester, completed in Se

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Melby, Nathaniel J. "Design and Development of a Framework for Traffic Management in a Global Manufacturing Enterprise: The American Standard Case Study." NSUWorks, 2015. http://nsuworks.nova.edu/gscis_etd/27.

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Managed Bandwidth Services (MBSs) use Quality of Service (QoS) guarantees to effectively control traffic flows and reduce network delay. In the past, the provision of MBS in a global manufacturing enterprise was a difficult task for network administrators. However, advances in recently emerging technologies, such as Multiprotocol Label Switching (MPLS), Generalized Multiprotocol Label Switching (GMPLS), Integrated Services (IntServ), Differentiated Services (DiffServ), and Constraint-based Routing (CBR), hold promise to make MBS implementation more manageable. QoS technologies, such as DiffSer

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Dupas, Agathe. "Modélisation et optimisation d'une machine synchrone à commutation de flux et à double excitation à bobinage global." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLN037/document.

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Les machines à double excitation (aimants permanents et bobines d’excitation) sont depuis quelques années étudiées par de nombreuses équipes de recherche dans le monde pour leur souplesse de fonctionnement et leur puissance volumique importante. Dans cette thèse, nous présentons une nouvelle structure de machine à double excitation. C’est une machine à commutation de flux, donc qui possède un rotor passif, et dont la partie de double excitation située au stator est maintenue par une culasse à griffes. Dans une première partie, les caractéristiques importantes de cette structure sont exposées à

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Hight, Allison M. ""Our Feet in the Present and Our Eyes on the Destination": A Literary Analysis of the Temporality of Internal Colonialism through the Works of Gloria Anzaldua and John Phillip Santos." Ohio University Honors Tutorial College / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1366986878.

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Lepp, Susanne. "A study of the use of English and other languages in TV-commercials in Sweden." Thesis, Karlstads universitet, Institutionen för språk, litteratur och interkultur, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-28429.

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This investigation is about the English language in Swedish TV-commercials. Theinvestigation shows that there are commercials in Sweden that involve other languages thanSwedish. The languages found in this study apart from Swedish were English, Italian andGerman. The results show that the most common language was Swedish, which was used in405 (96.4%) of the 420 commercial spots of which the data consists. In 57.6% of thecommercials Swedish was the only language that was used compared to the 3.6% spots whichonly included English. Swedish was used together with English, Italian or German in 159c

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Majoul, Amira. "Transmission du cycle économique des Etats Unis au reste du monde : le cas des pays émergents." Thesis, Lyon 2, 2014. http://www.theses.fr/2014LYO22002/document.

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La question de la transmission internationale des cycles a reçu une attention considérable en raison de l’intensification de la globalisation économique et financière. La problématique générale de cette thèse s’inscrit dans le prolongement de la littérature consacrée à cette question. Plus précisément, elle focalise son attention sur l’analyse de la transmission du cycle des Etats-Unis sur les pays émergents. Elle comporte trois chapitres. Le premier, en se basant sur une nouvelle approche économétrique en termes de modèle Global VAR, s’attache à étudier l’effet des chocs provenant des Etats-U

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Eickmeyer, David. "The Effects of Retrogressive Thaw Slump Development on Persistent Organic Pollutants in Lake Sediments of the Mackenzie River Delta Uplands, NT, Canada." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/25998.

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Using a comparative spatial and temporal analysis on sediment cores from 8 lakes in the Mackenzie River Delta uplands region, NT, Canada, this study assessed how persistent organic pollutant (POP) deposition to lake sediments was affected by: (1) the presence of retrogressive thaw slumps on lake shores; and (2) changes occurring with increased autochthonous primary productivity. POPs examined included polychlorinated biphenyls (PCBs), penta- and hexachlorobenzenes (CBzs), and dichlorodiphenyltrichloroethane and metabolites (DDTs). Surface sediments of slump-affected lakes contained higher tota

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Al-Qaisi, Talal, and 安奎道. "Optimization of AID somatic hypermutations system and in situ class switching of Globo H antibodies." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/2c257z.

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博士<br>國立陽明大學<br>生化暨分子生物研究所<br>106<br>Monoclonal antibodies have become a mainstream treatment option in oncology. Most therapeutic targets have been limited to surface receptors overexpressed on cancer cells. Globo H (GH) is a newly appreciated glycolipid for cancer targeting, which is overexpressed on several cancer types including breast, colon, lung, ovarian, gastric, pancreatic and prostate cancers as well as on breast cancer stem cells. GH was discovered more than 30 years ago, but only two specific antibodies have been reported; MBr1 and VK9.No antibodies against GH have yet been approve

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Bhimjee, Diptes Chandrakante Prabhudas. "Three essays on the global financial crisis of 2007-2008." Doctoral thesis, 2013. http://hdl.handle.net/10071/6867.

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JEL Classification Codes: G01, E5<br>The present Doctoral Thesis is comprised of three empirical essays addressing the Global Financial Crisis of 2007 – 2008. The said essays analyse distinct, but interconnected issues pertaining to this fundamental research topic. In the first paper, a careful examination is conducted in order to ascertain whether the ‘Subprime’ Crisis in the U.S.A. might have been duly forecasted using publicly available data. This hypothesis is confirmed by using two distinctive methodologies applied to a set of financial indicators, which independently confirm the predicta

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PARISE, LUIGI. "Service continuity in complex power systems: safety, operation and maintenance." Doctoral thesis, 2014. http://hdl.handle.net/11573/645095.

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The research aims to define electrical architectures based on the rationalization of the distribution structure and of power sources with the achievement of the primary objectives of service continuity, power quality, safety and safe maintenance. The thesis consists of two parts: the first part deals with the architecture impact on a complex system analyzing the system configuration and operational safety aspects. New developments and methodologies are presented in the study of critical systems. A theory of complex systems for safety, operation and maintenance aspects is defined that enables

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Moshirvaziri, Mazhar. "Ultracapacitor/Battery Hybrid Energy Storage Systems for Electric Vehicles." Thesis, 2012. http://hdl.handle.net/1807/33458.

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This thesis deals with the design of Hybrid Energy Storage System (HESS) for Light Electric Vehicles (LEV) and EVs. More specifically, a tri-mode high-efficiency non-isolated half-bridge converter is developed for the LEV based HESS applications. A 2 kW, 100 V interleaved two-phase converter prototype was implemented. The peak efficiency of 97.5% and a minimum efficiency of 88% over the full load range are achieved. Furthermore, a power-mix optimizer utilizing the real-time Global Positioning System (GPS) data for the EV based HESS is proposed. For a specific design, it is shown that at the co

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Zelenková, Alena. "Od lingvistických anomálií k subverzi moci: Narušování jazyka moci a vyjádření vykořeněnosti skrze střídání a míšení jazyků v literatuře." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-352561.

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This thesis explores literary code-switching, i.e. multilingual aspects within a single speech, as a key polyphonic structural element in the selected works. First, it analyzes Gloria Anzaldúa's Borderlands: The New Mestiza = La Frontera (1987) as a work, where the author seeks to establish a literary tradition that would reflect the life in borderlands and the given community through a new language. Secondly, the language of photography and multilingual speech patterns in W. G. Sebald's The Emigrants (1992) are considered as vital elements of the authenticity play. The following chapter deals

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