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Thèses sur le sujet « Golgi Apparatu »

Auteur : Grafiati

Publié le 10 mars 2023

Mis à jour le 19 juillet 2025

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1

D, Nolfi. "Studio morfologico e funzionale dell’apparato di Golgi in relazione ad una struttura LTL-positiva nelle cellule di carcinoma prostatico DU145." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1095701.

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The Golgi apparatus is a complex structure present in all eukaryotic cells. This organelle, which was first observed in 1989, still represents a fascinating enigma for much of its structural and functional peculiarity. Generally, the Golgi apparatus is known as the heart of the secretory pathway and glycosylation, which is one of the major post-traductional modifications. Most of the reactions of the glycosylation pathway occur in the Golgi apparatus, where glycosyltransferases and glycosidases modify glucidic chains by adding or removing monosaccharides. All the steps follow a precise seque

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2

Wong, Mei Wai Mie. "Functions of the golgin coiled-coil proteins of the Golgi apparatus." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708308.

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3

Au, Catherine. "Organellar proteomics of the Golgi apparatus and Golgi derived COPI vesicles." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18742.

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Studying an organelle with traditional biochemistry, histology, or microscopy techniques allows the determination of the presence of up to three proteins simultaneously. Mass spectrometry based proteomics has changed the study of organelles; for the first time it is possible to investigate the whole protein complement of a subcellular compartment. In this work I demonstrate our ability to use redundant peptide counting as a quantitative technique to compare the relative abundance of different proteins in a complex sample, specifically, enriched organellar preparations. I present the pipelin

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4

Dworkin, Joel. "Cell-free reconstitution of the Golgi apparatus." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59884.

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The Golgi apparatus is organized into a characteristic differentiated stack in all eukaryotic cells. During mitosis, the Golgi apparatus disassembles into smaller clustered vesicles lacking recognizable cisternae whereupon they recombine to form typical stacks in each of the daughter cells (Lucocq et al., 1987). Paiment et al. (1989) have demonstrated that dispersed (unstacked) Golgi fragments will reconstitute into a functional stacked Golgi apparatus when microinjected into Xenopus laevis oocytes. Disrupted hepatic Golgi fractions (Gi) were isolated on discontinuous sucrose gradients and inc

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5

Hui, Hu. "Targeting and retention in the Golgi apparatus." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263648.

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6

Radau, Boris. "Die Regulation der Vesikelbildung am trans-Golgi-Netzwerk durch Proteinkinase C." [S.l.] : [s.n.], 2001. http://www.diss.fu-berlin.de/2001/89/index.html.

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7

Li, Xue-Yi. "Characterization of a novel GPI-anchored protein, a component of sphingomyelin enriched microdomains at the Golgi complex." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967973775.

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8

Rivinoja, A. (Antti). "Golgi pH and glycosylation." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514292699.

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Abstract Glycans, as a part of glycoproteins, glycolipids and other glycoconjugates, are involved in many vital intra- and inter-cellular tasks, such as protein folding and sorting, protein quality control, vesicular trafficking, cell signalling, immunological defence, cell motility and adhesion. Therefore, their correct construction is crucial for the normal functioning of eukaryotic cells and organisms they form. Most cellular glycans are constructed in the Golgi, and abnormalities in their structure may derive, for instance, from alkalinization of the Golgi lumen. In this work we show th

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9

Gilchrist, Annalyn. "Proteomics analysis of the endoplasmic reticulum and Golgi apparatus." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18715.

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Isolated rough and smooth microsomes of the endoplasmic reticulum and isolated Golgi apparatus from rat liver were analyzed by proteomics using mass spectrometry, identifying 1064 proteins among the three fractions. An additional 598 proteins were identified by biochemically subfractionating the rough and smooth microsomes by treatment with a high salt wash and the detergent Triton-X 114. Proteins were quantified by redundant peptide counts which enabled an assessment of the extent of cross-contamination between the endoplasmic reticulum and Golgi fractions and other organellar contaminatio

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10

Rocchetti, Alessandra. "Interactions between the plant Golgi apparatus and the cytoskeleton." Thesis, Oxford Brookes University, 2016. https://radar.brookes.ac.uk/radar/items/e035b419-1acc-4031-aadd-2cfc1f9ed3c8/1/.

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In animal cells, the relationship between the Golgi apparatus and cytoskeleton has been well characterised but not much is known in plants. The functions of the Golgi apparatus are conserved amongst eukaryotes. It is one of the main stations in the secretory pathway and is involved in protein processing and sorting to different destinations. In plants, it is also involved in trafficking and positioning of cell wall components. In tobacco epidermal cells, fluorescent labelling with Golgi marker proteins has shown that the Golgi apparatus is made of hundreds of individual units scattered in the

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11

Short, Benjamin. "Characterisation of rab-effector complexes at the Golgi apparatus." Thesis, University of Glasgow, 2003. http://theses.gla.ac.uk/31014/.

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The rab family of small, ras-like GTPases regulate membrane trafficking events in the secretory and endocytic pathways. They appear to be involved in all stages of vesicular transport, from vesicle budding and cargo selection to motility, docking and membrane fusion. Through a cycle of GTP binding and hydrolysis, rab-effector proteins are recruited to membrane sub-domains in a temporally and spatially specific manner. Several rab proteins localise to the Golgi apparatus, the organelle consisting of stacked, flattened, membrane-bound cisternae through which newly-synthesised proteins are transi

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12

Albariri, Areej [Verfasser], and Thomas [Akademischer Betreuer] Kuner. "Golgi apparatus and Golgi outposts in neurons studied by correlative microscopy / Areej Albariri ; Betreuer: Thomas Kuner." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1220608793/34.

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13

Lock, John George. "Dynamic imaging of post-Golgi protein transport /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19397.pdf.

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14

Kam, Chuen. "Functional study of PICK1-ICA69 complex in the golgi apparatus /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202008%20KAM.

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15

Lian, Yen-Ling. "Mechanisms of retrograde transport from Golgi apparatus to endoplasmic reticulum." Electronic Thesis or Diss., Université Paris sciences et lettres, 2022. http://www.theses.fr/2022UPSLS067.

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Les cellules de mammifères sont caractérisées par la coexistence de plusieurs voies de transport, dont le transport antérograde et rétrograde. L'appareil de Golgi joue un rôle central dans le traitement et le tri des protéines dans le trafic bidirectionnel. Le système Retention Using Selective Hooks (RUSH) permet de synchroniser le transport des protéines depuis le RE et d'analyser systématiquement les voies sécrétoires. Grâce à l'interaction entre la streptavidine (Str) et un peptide de liaison à la streptavidine (Streptatividin Bioding Peptide, SBP), la protéine rapporteur peut être retenue

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16

Capitanio, Paola. "Effects of familial Alzheimer's disease-linked presenilin 2 mutants on Ca2+ homeostasis of Golgi Apparatus sub-compartments." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423438.

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Alzheimer's Disease (AD) is a progressive neurodegenerative disorder and the most common form of senile dementia. The characteristic histopathological hallmarks of AD are the intracellular neurofibrillary tangles and the amyloid plaques, made of aggregated amyloid peptides (Aß), that deposit in the extracellular matrix of the brain. Aß peptides are the result of two sequential cleavages of the amyloid precursor protein (APP); Aß is eventually released by the α-secretase enzyme. The most abundant Aß peptide species, both physiologically produced throughout life, are Aß40 and Aß42, which is more

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17

Miranda, Kevin Charles. "Post-Golgi trafficking in the mammalian secretory pathway /." [St. Lucia, Qld], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18194.pdf.

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18

Dong, Jiaxin. "Impact of dynamin II domains on the function of dynamin II in vesicle formation at the trans Golgi network." [S.l.] : [s.n.], 2001. http://www.diss.fu-berlin.de/2001/72/index.html.

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19

Pecot, Matthew Y. "A declaration of independence the Golgi apparatus is here to stay /." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3225895.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed October 8, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 107-115).

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20

Poe, Tyler M., and Francine Marciano-Cabral. "Illumination of the Golgi apparatus of Pathogenic and Nonpathogenic Naegleria species." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/6002.

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In this study, Naegleria fowleri, a pathogenic amoeba and the causative agent of Primary Amebic Meningoencephalitis (PAM), was utilized to determine the presence or absence of classically conserved Golgi molecules featured in the expression of a Golgi apparatus. Previous studies concluded no Golgi expression via light microscopy and transmission electron microscopy, but a recent report on Naegleria gruberi indicated the presence of dispersed Golgi tubules. Non-pathogenic species of the Naegleria genus such as Naegleria gruberi 30540 and Naegleria lovaniensis 30569 were utilized in Western immu

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Nawazi, Fazlullah Salar Khan. "Golgi specificity and development of autoreactive B cells." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-019-Nawazi-index.html.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2008.<br>Title from title page screen (viewed on September 9, 2008). Research advisor: Marko Z. Radic, Ph.D. Document formatted into pages (xi,111 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 91-111).

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22

Lipinski, Anette Rejman. "Rab-Proteine kontrollieren die Chlamydien-induzierte Fragmentierung des Golgi-Apparates." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15945.

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Weltweit kommt es jährlich zu 90 Mio. Neuinfektionen mit dem sexuell übertragbaren Erreger Chlamydia trachomatis. Allerdings sind die Faktoren, die eine erfolgreiche bakterielle Vermehrung ermöglichen, weitgehend unbekannt. Während ihrer obligat intrazellulären Entwicklung sind Chlamydien auf die Errichtung und Erhaltung ihrer Nische, der Inklusion, angewiesen. Durch Interaktionen mit vesikulären Transportwegen der Wirtszelle, welche z.B. Sphingolipide transportieren, sichern die Bakterien ihr Überleben. In der vorliegenden Arbeit konnte gezeigt werden, dass Chlamydien während einer Infekti

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23

Kong, Anne Mandy 1973. "Cloning and characterisation of a novel 72 kDa inositol polyphosphate 5-phosphatase." Monash University, Dept. of Biochemistry and Molecular Biology, 2001. http://arrow.monash.edu.au/hdl/1959.1/9036.

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24

Zamzow, Daniel R. "Signaling capabilities of a novel H-Ras mutant from the Golgi apparatus." [Ames, Iowa : Iowa State University], 2006.

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25

Wiggins, Christine Anne Ruth. "Identification and characterisation of proteins from the Golgi apparatus of S. cerevisiae." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624979.

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26

Marotta, D. "Defining the role of the Golgi apparatus in juvenile NCL (Batten disease)." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1460387/.

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The neuronal ceroid lipofuscinoses (NCLs) are a group of severe neurodegenerative lysosomal storage disorders characterised by accumulation of autofluorescent ceroid lipopigments in most cells. NCLs are caused by mutations in at least fourteen recessively inherited human genes. The NCL genes encode both soluble and transmembrane proteins localised to the endoplasmic reticulum, Golgi apparatus or endosomal/lysosomal organelles. Mutations in the CLN3 gene result in juvenile neuronal ceroid lipofuscinoses (JNCL, Batten disease). JNCL represents the worldwide most common form of NCL. Currently mor

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27

Howe, Jonathon David. "Antiviral mechanisms of small molecules targeting the endoplasmic reticulum and Golgi apparatus." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:04368b4b-2fd3-4fc7-8f89-ec39cd87e37d.

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N-linked glycosylation is the most common form of post-translational modification in nature and is essential to almost all enveloped viruses, including members of the Flaviviridae family. The host cell N-linked glycoprotein processing pathway is utilised by these viruses and as such has long been identified as a potential target for the development of antiviral drugs. Here, the antiviral mechanisms of three classes of small molecules targeting the secretory pathway and altering viral envelope glycosylation are investigated, using the HCV surrogate model, BVDV. The antiviral activity of imino s

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28

Stüven, Ernstpeter. "Identifizierung von Mikrodomän-Proteinen und funktionelle Charakterisierung von Cholesterin im Golgi-Apparat." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965291324.

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29

Guet, David. "Architecture of the Golgi apparatus and membrane trafficking probed by intracellular optical micromanipulation." Paris 6, 2012. http://www.theses.fr/2012PA066203.

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Le trafic membranaire est basé sur la formation d'intermédiaires de transports qui transitent d'un compartiment à un autre. Des études in vitro ont montré que des paramètres physiques tels que la courbure, la tensione et la composition des membranes influence le bourgeonnement et la fission de ces intermédiaires. Plus récemment le rôle du cytosquelette d'actine dans la fission de ces vésicules a été mis en avant. Au cours de mon doctorat je me suis intéresé à l'effet d'un stress mécanique sur la formation de vésicules in cellulo. Dans cette thèse je montre que l'utilisation de la microscopie c

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30

Starr, Tregei Nicole. "Quantitative Studies of Intracellular Trafficking of Two Classes of Resident Golgi Apparatus Proteins." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/27217.

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The research presented in this dissertation consists of two primary parts. The initial focus centered on understanding the distribution of Golgi resident glycosyltransferases between the ER and Golgi at steady-state. Retrograde trafficking of these Golgi proteins has been demonstrated experimentally mandating the existence of a dynamic equilibrium between the Golgi apparatus and ER. Our published studies also included the development of a quantitative method for analysis of data collected using fluorescent microscopy. The second part of this dissertation presents results pertaining to the qua

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31

Heymann, Julia. "Chlamydia infection impairs host cell motility via CPAF-mediated Golgi fragmentation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16564.

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Chlamydien sind obligat intrazelluläre Bakterien, die sich in einem membranumschlossenen Kompartiment namens Inklusion vermehren. Nach Infektion fragmentiert der Golgi-Apparat der Wirtszelle in kleine Membranstapel. Dies verbessert die Aufnahme von Sphingolipiden und ist deshalb für die chlamydiale Vermehrung essentiell. Die infektionsinduzierte Golgi-Fragmentierung geschieht nach Spaltung des Golgi-Matrix-Proteins Golgin-84. In dieser Arbeit konnte, durch den Vergleich mit bekannten Substraten und Inhibitorstudien, die chlamydiale Protease CPAF (Chlamydia protease-like activity factor) als

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32

Fossati, M. "MECHANISMS OF PROTEIN TRANSPORT AT THE ER-GOLGI INTERFACE." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/214981.

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The Endoplasmic Reticulum represents the first station of the secretory path-way, where proteins destined to the cell surface or to some intracellular organelles are recruited in specific ER subdomains, the ER Exit Sites (ERES), and start to travel into transport carriers to reach the proper final destination. Even though cargoes are usual-ly recruited to ERES by a sequence-dependent mechanism, it is known that other fac-tors contribute to protein export from the ER. Using model fluorescent tail-anchored proteins our group previously demonstrated that the length/hydrophobicity of the transmemb

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33

Fuchs, Evelyn. "Regulation of Membrane Traffic at the Golgi Apparatus by Rab GTPases and their GAPs." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-82832.

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34

Ali, Zahabia Shameem. "Investigating the role of AMPK in carbohydrate sensing and localisation at the golgi apparatus." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501761.

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35

Fuchs, Evelyn. "Regulation of membrane traffic at the golgi apparatus by rab GTPases and their GAPs." kostenfrei, 2007. http://edoc.ub.uni-muenchen.de/8283/.

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36

Deng, Yuping. "Studies of intraorganelle dynamics : the lysosome, the pre-lysosomal compartment, and the golgi apparatus /." Diss., This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-07282008-134815/.

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37

Dahan, Sophie. "Intracellular proteinmembrane trafficking : evaluation of the Golgi and endosomal apparatus by cryoimmune electron microscopy." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29387.

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Protein trafficking events in the secretory and endosomal apparatus were evaluated in rat liver hepatocytes by EM immunogold cytochemistry. The cellular distribution of apolipoprotein E and other abundant hepatic secretory and endosomal proteins was quantitatively examined in ultrathin cryosections of liver hepatocytes. Under steady-state conditions, apoE was concentrated within the Golgi apparatus, along sinusoidal plasma membrane microvilli and within all components of the endosomal apparatus, as evaluated immunocytochemically and confirmed by quantitative immunoblotting of organelles isolat

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38

Foote, Christopher. "The role of the AP-1 adaptor complex in trafficking between the trans-Golgi Network and endosomal system." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4172.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (November 7, 2006) Vita. Includes bibliographical references.

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39

Compton, Shannon Leigh. "Functional analysis of PRAF1 and its effect on corticotrophic ACTH secretion." Auburn, Ala., 2007. http://repo.lib.auburn.edu/07M%20Dissertations/COMPTON_SHANNON_44.pdf.

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Matiach, Alexei. "Retrograde protein trafficking of Emp47p in the early secretory pathway of S. cerevisiae a novel mutant screen uncovers the influence of oxidative stress on protein trafficking /." Kassel : Kassel Univ. Press, 2002. http://deposit.d-nb.de/cgi-bin/dokserv?idn=970323417.

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Weigert, Roberto. "Biochemical analysis of the factors controlling the process of membrane tubule formation from the Golgi complex." Thesis, Open University, 2000. http://oro.open.ac.uk/58143/.

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Membranous tubules are very abundant structures in living cells and form or are part of most intracellular organelles. The Golgi apparatus is mainly formed by tubules, which adopt different geometries and conformations. However, their physiological role has not yet been established and this is mainly due to the almost absolute lack of knowledge about the biochemical mechanisms regulating their formation, maintenance and disruption. The aim of this thesis was to investigate in a systematic way these mechanisms. The first step has been to set up an in vitro morphological assay suitable for the v

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Hiding, Johan. "Functional characterization of the secretory pathway and the role of COPI vesicles /." Göteborg : Göteborg University, Institute of Biomedicine, Department of Medical Genetics, Sahlgrenska Academy, Göteborg University, 2007. http://hdl.handle.net/2077/8502.

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Cheong, Fei Ying. "Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-71011.

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Young, Robin Elizabeth. "Secretion of plant cell wall polysaccharides by the Golgi apparatus in Arabidopsis thaliana seed coat cells." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/11573.

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The plant cell wall determines cell shape and is essential for plant growth during development. Pectin is an important component of cell walls and, like many wall polysaccharides, is synthesized in the Golgi apparatus and secreted by vesicles. In Arabidopsis thaliana seed coats, pectin-rich mucilage is secreted in a polarized fashion during a specific stage of development. How the Golgi apparatus in seed coat cells accommodates the large increase in pectin-rich mucilage provides a unique window into the cellular machinery that supports cell wall polysaccharide biosynthesis and secretion. Exam

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45

Millarte, Valentina [Verfasser]. "Signaling at the Golgi Apparatus During Cell Migration and Implication for Cancer Cell Metastasis / Valentina Millarte." Konstanz : Bibliothek der Universität Konstanz, 2015. http://d-nb.info/1080908919/34.

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46

Szul, Tomasz J. "The role of GBF1 in Golgi biogenesis and secretory traffic." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/szul.pdf.

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47

Bellouze, Sarah. "Mécanismes moléculaires de la fragmentation de l' appareil de Golgi dans les maladies du neurone moteur." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4080.

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La fragmentation de l'appareil de Golgi représente un des changements les plus précoces et les plus répandus dans les maladies neurodégénératives. Afin de comprendre les mécanismes moléculaires de ces changements, j'ai étudié deux modèles expérimentaux de maladie du neurone moteur. 1. Les souris pmn (progressive motor neuronopathy) : Celles-ci sont atteintes d'une forme très grave de dégénérescence des neurones moteurs et des défauts moléculaires sont liés à une mutation faux-sens d'une protéine localisée au niveau du Golgi, la chaperonne des tubulines TBCE, identifiée par (Martin, Jaubert et

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Grabski, Robert. "Using RNA interference to study the function of the tethering protein p115 in ER-Golgi traffic." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/grabski.pdf.

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Bailly, Anne-Laure. "Rôle de GRASP-55 dans la spermatogenèse et la différenciation hématopoïétique." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4112.

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Les molécules d’adhésion jonctionnelles JAM-B et JAM-C forment une paire récepteur/ligand impliquée dans la régulation de nombreux mécanismes biologiques dont l’inflammation, l’hématopoïèse et la spermatogénèse. Dans la moelle osseuse, l’interaction entre JAM-C et JAM-B, respectivement exprimée par les cellules souches hématopoïétiques (CSH) et les cellules stromales, joue un rôle dans la rétention et la quiescence des CSH. Dans le testicule, JAM-C participe à la polarisation des spermatides en différenciation en interagissant avec JAM-B exprimée par les cellules de Sertoli. GRASP55 (Golgi ReA

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Nevalainen, M. (Mika). "Gene product targeting into and membrane trafficking from the endoplasmic/sarcoplasmic reticulum in skeletal myofibers." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526200637.

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Abstract Skeletal muscle cells (myofibers) are huge multinucleated cells responsible for muscle contraction and hence for the everyday movements of the joints. The structure of these voluminous cells differs greatly from that of the mononucleated cells – the characteristic features of the myofibers include dozens of peripherally located nuclei, tightly packed contractile apparatus and a sophisticatedly organized endomembrane system. The basic physiology involving myofibers is quite well known, but scarce data exist on the membrane biology of the myofibers. The purpose of this study was to exam

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