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Littérature scientifique sur le sujet « He53 »

Auteur : Grafiati

Publié le 25 juillet 2024

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "He53"

Kent, Matthew R., Delia Calderon, Katherine M. Silvius, et al. "Abstract 3533: Zebrafish her3 knockout impacts developmental and rhabdomyosarcoma-related gene signatures." Cancer Research 83, no. 7_Supplement (2023): 3533. http://dx.doi.org/10.1158/1538-7445.am2023-3533.

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Abstract HES3 is a basic helix-loop-helix transcription factor that regulates neural stem cell renewal during development. HES3 overexpression is predictive of reduced overall survival in patients with fusion-positive rhabdomyosarcoma, a pediatric cancer that resembles immature and undifferentiated skeletal muscle and is most commonly driven by the fusion-oncogene PAX3-FOXO1. However, the mechanisms of HES3 cooperation in PAX3-FOXO1 driven rhabdomyosarcoma are unclear and are likely related to her3/HES3’s role in neurogenesis. To investigate HES3’s function during development, we generated a z

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Santana, Ana Flávia Mendonça, André Luís Teixeira Fernandes, Everaldo Miranda, Leonardo Otávio Coronado, Lourena Rios Tibery, and José Roberto Delalibera Finzer. "HOPS: The Aromatic Ingredient of Breweries." Revista de Gestão Social e Ambiental 18, no. 9 (2024): e08463. http://dx.doi.org/10.24857/rgsa.v18n9-200.

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Objective: The main objective of this study is to produce and characterize the raw material used to manufacture beer, including planting and harvesting by one of the largest brewing groups in the country, the Petropólis group, with a unit installed in the city of Uberaba/MG with a built area of 108,000 m². Theoretical Framework: Most hops used for brewing in Brazil are imported from countries such as Germany and the United States. However, certain varieties have adapted to the Brazilian climate and achieved significant yields and qualities. Method: Hop samples were collected in the city of Ube

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Beckford Vera, Denis, Jason Li, Le-Cun Xu, et al. "Preclinical evaluation of novel HER3-targeting radioconjugates for the imaging and treatment of HER3-expressing cancers." Journal of Clinical Oncology 41, no. 16_suppl (2023): e15114-e15114. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e15114.

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e15114 Background: HER3 overexpression in tumors is associated with poor survival and is implicated in drug resistance mechanisms of HER1 (EGFR) and HER2 targeted therapies. Although antibodies against HER3 have been developed and evaluated in clinical trials, no HER3 targeted therapy has been approved, underscoring the unmet need for novel HER3 therapeutic approaches. We hypothesized that HER3 radioligand targeted therapies could provide enhanced therapeutic efficacy against HER3-positive cancers through the energy deposited by alpha or beta emitting radionuclides in tumor cells. Here we desc

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Koyama, Kumiko, Hirokazu Ishikawa, Manabu Abe, et al. "Patritumab deruxtecan (HER3-DXd), a novel HER3 directed antibody drug conjugate, exhibits in vitro activity against breast cancer cells expressing HER3 mutations with and without HER2 overexpression." PLOS ONE 17, no. 5 (2022): e0267027. http://dx.doi.org/10.1371/journal.pone.0267027.

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ErbB3 (HER3), a member of the HER family, is overexpressed in various cancers and plays an important role in cell proliferation and survival. Certain HER3 mutations have also been identified as oncogenic drivers, making them potential therapeutic targets. In the current study, antitumor activity of patritumab deruxtecan (HER3-DXd), a HER3 directed antibody drug conjugate, was evaluated in tumor models with clinically reported HER3 mutations. MDA-MB-231, a HER3-negative human triple-negative breast cancer cell line, was transduced with lentiviral vectors encoding HER3 wild type (HER3WT), one of

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Komatsu, Nagiho, Saori Sato, Sumie Muramatsu, Ryuichi Nakamura, and Kumiko Koyama. "Abstract 3996: The impact of HER3 dynamics on the efficacy of HER3-DXd, a novel HER3 directed antibody-drug conjugate." Cancer Research 83, no. 7_Supplement (2023): 3996. http://dx.doi.org/10.1158/1538-7445.am2023-3996.

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Abstract Background: HER3 is broadly expressed in various solid tumor types, and its expression can be upregulated by treatment with receptor tyrosine kinase inhibitors (RTKi) such as EGFR TKIs used to treat EGFR-mutated NSCLC. HER3-DXd, a novel antibody-drug conjugate (ADC) composed of a human anti-HER3 IgG1 monoclonal antibody (patritumab) covalently linked to a topoisomerase I inhibitor payload (DXd), is currently being studied in clinical trials for breast cancer and NSCLC. As previously reported, HER3-DXd treatment transiently decreases HER3 expression levels in tumors and EGFR TKIs incre

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O'Hare, Thomas, Jaclyn Cleveland, Valerie M. Jansen, and David Dornan. "Abstract 3121: Therapeutic potential of a HER3 antibody-drug conjugate for the treatment of HER3-expressing cancers." Cancer Research 84, no. 6_Supplement (2024): 3121. http://dx.doi.org/10.1158/1538-7445.am2024-3121.

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Abstract To address the need for targeted therapy in the treatment of HER3-positive solid tumors, the human HER3 mAb, seribantumab, was evaluated in the context of an antibody-drug conjugate (ADC). As a proof-of-concept, seribantumab was conjugated with a cleavable valine-citrulline linker and monomethyl auristatin E (MMAE) payload via the stochastic cysteine conjugation method to yield HER3-ADC1. A drug-antibody ratio of 4 was selected for preclinical assessment in HER3-expressing models. Methods: HER3-ADC1 was evaluated in vitro and in vivo, with patritumab deruxtecan (patri-DXd) as a compar

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Beckford-Vera, Denis, Megan McCloskey, Jason Li, et al. "Abstract 5040: Novel HER3 targeting antibody radioconjugates, 225Ac-HER3 ARC and 177Lu-HER3 ARC, exhibit potent antitumor efficacy in HER3-positive solid tumors." Cancer Research 83, no. 7_Supplement (2023): 5040. http://dx.doi.org/10.1158/1538-7445.am2023-5040.

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Abstract Background: HER3 is a unique member of the EGFR family that collaborates with other EGFR receptors to induce tumorigenesis and drug resistance. Moreover, HER3 expression is linked to poor survival for patients with solid tumors. Despite HER3 being a rational cancer therapeutic target, no HER3-directed therapies have been approved for clinical use. However, new therapeutic strategies such as antibody drug conjugates (ADCs) are being investigated. Targeted radiotherapy, including radiolabeled antibodies (ARCs), is unique mechanistically by inducing cell death independent of biologic pat

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Toy, Weiyi, Dipti Thakkar, Roberto Magallanes, et al. "Abstract 5796: A HER3 antibody that uniquely blocks the HER3 heterodimerization interface effectively inhibits tumor growth in pre-clinical models with potentially oncogenic HER3 mutations." Cancer Research 84, no. 6_Supplement (2024): 5796. http://dx.doi.org/10.1158/1538-7445.am2024-5796.

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Abstract HER3 activation, via NRG1 ligand-dependent and -independent heterodimerization with HER2 or EGFR, has been associated with tumor progression and acquired resistance to therapies in multiple indications. HER3 mutations, detected in around 3% of cancer cases, may drive oncogenic signaling, leading to rapid tumor growth. Currently, there are no approved targeted therapies for HER3 mutations. Through analysis of real-world data and structural modelling of HER3 heterodimers, we identified four common HER3 mutations located within or close to the dimerization interface of HER3, suggesting a

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Beckford-Vera, Denis, Jason Li, Megan McCloskey, et al. "Abstract 3306: Targeting HER3 receptor positive cancers with a novel anti-HER3 antibody radioconjugate (ARC)." Cancer Research 82, no. 12_Supplement (2022): 3306. http://dx.doi.org/10.1158/1538-7445.am2022-3306.

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Abstract Background: HER3 overexpression is reported to be associated with poor survival in breast, ovarian, lung, gastric and prostate cancer. In addition, upregulation of HER3 in response to HER1 or HER2 targeted therapies, is implicated in the acquired resistance against these therapies. Therefore, effective targeting of HER3 can potentially overcome resistance and enhance therapeutic efficacy. Although a number of anti-HER3 antibodies have failed clinical testing with the development focus being shifted to other approaches such as antibody drug conjugates and bispecific antibodies, there a

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Scartozzi, M., A. Mandolesi, R. Giampieri, et al. "The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan/cetuximab." Journal of Clinical Oncology 29, no. 4_suppl (2011): 404. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.404.

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404 Background: Preclinical data suggested that in presence of HER3 altered activation colorectal cancer cells may escape anti-EGFR mediated cell death. HER3 overexpression may then represent a key factor for resistance to anti-EGFR antibodies in colorectal cancer. The aim of our analysis was to investigate a possible correlation between HER3 expression and clinical outcome in KRAS wild-type advanced colorectal cancer receiving cetuximab and irinotecan. Methods: We retrospectively analyzed immunoreactivity for HER3 in KRAS wild-type advanced colorectal cancer patients receiving irinotecan-cetu

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Thèses sur le sujet "He53"

BON, GIULIA. "Dual targeting of HER3 and MEK may overcome HER3-dependent chemoresistance of colon cancers." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/202145.

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The medical treatment of colorectal cancer (CRC) has evolved greatly in the last years, involving combined chemotherapy protocols and, more recently, new biologic agents. Nevertheless, prognosis remains adverse for patients with metastatic disease and a significant portion of early-stage patients develop recurrence after chemotherapy. Clinical trials are now directed to evaluate new drug combinations and treatment schedules in order to overcome the mechanisms of chemoresistance. By the use of two patient-derived colon cancer cell lines, CC09 (BRAFV600E) and R511 (wt BRAF), and the established

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Aldana, Hidalgo Julio Xavier, Parodi Augusto José Amador, Palacios Jorge Martin Arredondo, et al. "Estrategias de redacción - HE59 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/624389.

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Descripción: Estrategias de Redacción es un curso de Humanidades, que brinda al participante un conjunto de herramientas lingüísticas para la redacción en el entorno laboral, tales como el uso apropiado de la normativa del español y la aplicación de estrategias de redacción como la enumerativa y la causal. Estas últimas se emplean en la elaboración de un tipo de documento: el informe de recomendación. Propósito: El curso desarrolla la competencia de comunicación escrita en el primer nivel de logro. La asignatura se orienta a la redacción de textos administrativos que ayuden a optimizar el

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(UPC), Universidad Peruana de Ciencias Aplicadas, and Celis Ingunza Sandy Cecilia. "Creatividad Y Liderazgo-HE50-201601." Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/639326.

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Creatividad y Liderazgo es un curso de formación general de carácter teórico y práctico que está dirigido a estudiantes de quinto ciclo a más de las Facultades de negocios e Ingeniería y que desarrolla una de las competencias generales de nuestro modelo educativo: Pensamiento Innovador.El curso Creatividad y Liderazgo surge como una respuesta a los vertiginosos cambios tecnológicos y sociales que ocurren en nuestros días los que a su vez producen profundas transformaciones en la cultura corporativa de empresas e instituciones. Esto enfrenta a los ejecutivos a cada vez mayores exigencias profes

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(UPC), Universidad Peruana de Ciencias Aplicadas, and Garcia Soria Juddy Grethel Nora. "Creatividad Y Liderazgo-HE50-201602." Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/639327.

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(UPC), Universidad Peruana de Ciencias Aplicadas, and Ilizarbe Jurado Anndy Antonio. "Creatividad Y Liderazgo-HE50-201701." Universidad Peruana de Ciencias Aplicadas (UPC), 2017. http://hdl.handle.net/10757/639328.

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Creatividad y Liderazgo es un curso de formación general de carácter teórico y práctico que está dirigido a estudiantes de quinto ciclo a más de las Facultades de Negocios e Ingeniería y busca desarrollar una de las competencias generales de nuestro modelo educativo: Pensamiento Innovador.El curso Creatividad y Liderazgo surge como una respuesta a la necesidad de profesionales que cuenten con estrategias y metodologías para afrontar los vertiginosos cambios que ocurren en nuestros días los que a su vez producen profundas transformaciones en la cultura corporativa de empresas e instituciones. E

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Bass, Tarek. "Affibody molecules targeting HER3 for cancer therapy." Doctoral thesis, KTH, Proteinteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-204593.

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The development of targeted therapy has contributed tremendously to the treatment of patients with cancer. The use of highly specific affinity proteins to target cancer cells has become a standard in treatment strategies for several different cancers. In light of this, many cancer cell markers are investigated for their potential use in diagnostics and therapy. One such marker is the human epidermal growth factor receptor 3, HER3. It has been established as an important contributor to many cancer types. The function of HER3 is to relay cell growth signals from outside of the cell to the inside

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Htun, van der Horst Edward. "The role of ErbB3/HER3 in gliomas and breast cancer." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-5804.

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Claus, J. "The pseudokinase HER3 : structure/function relationships and inhibitor-induced signalling." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1457524/.

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The receptor tyrosine kinase HER3, a pseudokinase in the epidermal growth factor receptor (EGFR) family, is involved in responses to ligands and in the acquired resistance against HER2-directed targeted therapy in breast cancer. In this thesis I aim to further investigate the structure/function relationships at the basis of HER2- HER3 heterodimerisation, particularly in response to inhibitor treatment. The data presented here shows that in HER2+ breast cancer cells treated with the HER2 inhibitor lapatinib, stimulation with the HER3 ligand NRG is able to not only rescue cytotoxicity, but even

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Franks, P. W. "A He3 magnetometer for the EDM experiment." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304321.

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Xie, Ting. "Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11384.

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With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted with small molecule inhibitors. During the past five years, I have been working on figuring out the path to inhibit two elusive cancer targets: Her3 and KRas.<br>Chemistry and Chemical Biology

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Livres sur le sujet "He53"

cai, Jin sheng. Ping di ke ^wei guan jing ji xue~ (di4 he5 ban) bi ji he ke hou xi ti xiang jie. Zhong guo shi hua chu ban she, 2006.

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Kay, Bartholomew L., ed. Planning health promotion programs: An intervention mapping approach. Jossey-Bass, 2006.

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Sole, Kathy. Making Connections: Understanding Interpersonal Communications. Zovio Inc., 2011.

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Making Meaning, Making Sense: Children's Early Language Learning. Zovio Inc., 2012.

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Financial Management of Health Care Organizations: An Introduction to Fundamental Tools, Concepts and Applications. Wiley & Sons, Limited, John, 2020.

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Financial Management of Health Care Organizations: An Introduction to Fundamental Tools, Concepts and Applications. Wiley & Sons, Incorporated, John, 2020.

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Kaya, Gökalp. He3. Independently Published, 2020.

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Fischer, Benjamin. He3 the Novel. Independently Published, 2017.

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He3: The Novel. Independent Publisher, 2010.

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Popkin, Michael H. Preparation for Active Parenting/He23. South-Western Pub, 1988.

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Chapitres de livres sur le sujet "He53"

Lugovskoy, Alexey, Michael Curley, Johanna Lahdenranta, et al. "HER3." In Cancer Therapeutic Targets. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4419-0717-2_95.

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Lugovskoy, Alexey, Michael Curley, Johanna Lahdenranta, et al. "HER3." In Cancer Therapeutic Targets. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-6613-0_95-1.

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MacLeod, Sheena H., Kyle G. Potts, Shyambabu Chaurasiya, and Mary M. Hitt. "Assessment of Specificity of an Adenovirus Targeted to HER3/4." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7219-7_18.

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Heindler, Manfred. "Feasibility, Safety and Environmental Aspects of D-He3 Fusion." In Safety, Environmental Impact, and Economic Prospects of Nuclear Fusion. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0619-1_11.

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Kartavtsev, O. I. "Universal description of the He3 system at low energy." In Few-Body Problems in Physics ’98. Springer Vienna, 1999. http://dx.doi.org/10.1007/978-3-7091-6798-4_33.

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Rostoker, Norman, and Michl Binderbauer. "Self-Colliding Beams as an Alternative Fusion System for D-He3 Reactors." In Current Trends in International Fusion Research. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5867-5_4.

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Moldover, M. R., and W. A. Little. "Specific Heat of He3 and He4 in the Neighborhood of their Critical Points." In From High-Temperature Superconductivity to Microminiature Refrigeration. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0411-1_7.

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Sarkar, Mitul, and John G. Koland. "Fluorescence Recovery After Photobleaching Analysis of the Diffusional Mobility of Plasma Membrane Proteins: HER3 Mobility in Breast Cancer Cell Membranes." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3170-5_9.

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"HER3." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_2678.

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Hesketh, Robin. "HER3/ERbB-3." In The Oncogene & Tumour Suppressor Gene Factsbook. Elsevier, 1997. http://dx.doi.org/10.1016/b978-012344548-3/50043-1.

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Actes de conférences sur le sujet "He53"

Chen, Min. "Influence of Helium Cluster Structure on Diffusion Behavior." In 2013 21st International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icone21-15478.

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The migration processes of He cluster in Ti have been simulated in detail using molecular dynamics. It is observed that He2 has no preferred molecular orientation in the migration process. He2 is observed to migrate quickly across the Ti atom layer when its molecular orientation is in the direction of perpendicularity to [001] axis. And it is difficult for He2 to migrate across the Ti atom layer when its orientation is along the [001] axis. He2 only induce a slight rearrangement of its nearby Ti atoms as it migration. As He3 significantly deviates from the orientation of (001) plane, it migrat

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Kol, Arjan, Martin Pool, Steven de Jong, Elisabeth GE de Vries, Marjolijn N. Lub-de Hooge, and Anton GT Terwisscha van Scheltinga. "Abstract LB-B11: Assessment of HER3 status during lapatinib treatment in HER3-positive breast cancer using 89Zr-anti-HER3 mAb." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-lb-b11.

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Hettmann, Thore, Matthias Schneider, Selam Ogbagabriel, et al. "Abstract LB-306: U3-1287 (AMG 888), a fully human anti-HER3 mAb, inhibits HER3 activation and induces HER3 internalization and degradation." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-lb-306.

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Ghoranneviss, Mahmoud, Babak Malekynia, Nader Azizi, Henrich Hora, and George H. Miley. "Alternative Laser Driven Fusion Reactions for Nuclear Energy Without Radioactivity." In 18th International Conference on Nuclear Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/icone18-29945.

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Following the first result of generating nuclear fusion energy without dangerous radioactive radiation by laser ignition of the proton-11Boron reaction (HB11), we applied this method to evaluate other fusion reactions with no primary neutron production as the proton-7Lithium reaction (HLi7) and of the burning of solid density helium isotope 3He (He3-He3). The new method is a combination of now available laser pulses of 10 petawatt (PW) power and duration in the range of picoseconds (ps) or less. The new mechanism follows the initial theory of Chu and of Bobin for side-on ignition of solid stat

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"HE3: power measurements." In Proceedings of the 21st IEEE Instrumentation and Measurement Technology Conference. IEEE, 2004. http://dx.doi.org/10.1109/imtc.2004.1351506.

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"HE5: temperature measurement." In Proceedings of the 21st IEEE Instrumentation and Measurement Technology Conference. IEEE, 2004. http://dx.doi.org/10.1109/imtc.2004.1351517.

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Pinzon-Ortiz, Maria C., Xianhui Rong, Richard Versace, Qing Sheng, and Z. Alexander Cao. "Abstract 5320: Targeting HER3 and EGFR in NRG1 positive and HER3 mutated lung squamous cell carcinoma." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5320.

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Mukherjee, A., Y. Badal, X. Nguyen, et al. "Proximity-based assays for the detection of activated HER3, HER2/HER3 heterodimers and HER3/PI3K complexes in formalin-fixed, paraffin-embedded cell line controls and tumors." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-4040.

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Zhang, Weixing, Way Kuo, and Victor M. Tamashunas. "Simulating the (HE3/HE3/S):(PRP/ ∞ / ∞) queuing model for a maintenance problem." In the 17th conference. ACM Press, 1985. http://dx.doi.org/10.1145/21850.253317.

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Garrett, Joan T., Cammie R. Sutton, Carl Uli Bialucha, et al. "Abstract 5461: A HER3 antibody that blocks ligand-independent HER2-HER3 dimerization sensitizes to HER2 and PI3K inhibitors ." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5461.

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Rapports d'organisations sur le sujet "He53"

Lyerly, H. K. Developing a HER3 Vaccine to Prevent Resistance to Endocrine Therapy. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada612924.

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Lyerly, H. K. Developing a HER3 Vaccine to Prevent Resistance to Endocrine Therapy. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada597890.

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Dittrich, T. R., B. A. Hammel, and C. J. Keane. Diagnosis of pusher-fuel mix in indirectly driven Nova implosions (HEP3). Office of Scientific and Technical Information (OSTI), 1996. http://dx.doi.org/10.2172/376961.

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Wampler, William. Measurement of Boron by He3 Nuclear Reaction Analysis. Office of Scientific and Technical Information (OSTI), 2025. https://doi.org/10.2172/2540209.

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Ong, Nai P. Acquisition of He3 Cryostat Insert for Experiments on Topological Insulators. Defense Technical Information Center, 2016. http://dx.doi.org/10.21236/ad1007436.

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Trichtchenko, L., L. Nikitina, and M. Harrison. Statistical analysis of space environment on highly elliptical orbits. HEO1 and HEO3 missions data. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2013. http://dx.doi.org/10.4095/292717.

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