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Thèses sur le sujet « Head and neck tumour »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Sundelin, Kaarina. "Head and Neck Cancer : Factors Affecting Tumour Growth." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1032s.pdf.

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2

Murray, Patrick Francis. "Immunomodulation within the head and neck tumour microenvironment." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:10124.

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Changes in the immune response have been implicated in the progression of squamous cell carcinoma of the head and neck (HNSCC). Evidence is emerging that processes within the tumour microenvironment can lead to immune modulation and subsequent tumour growth or metastasis. The hypothesis of this thesis is that the HNSCC tumour microenvironment will have increased levels of cytokines that produce an overall negative effect on the cellular cytotoxic immune response against the malignant cells. Specifically, it is hypothesised that a Th-2-like anti-inflammatory response will favour tumour cell pro

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3

Kulasinghe, Arutha Jeevana. "Circulating tumour cells in head and neck cancers." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/110534/1/Arutha%20Jeevana_Kulasinghe_Thesis.pdf.

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Metastasis in head and neck cancer patients is responsible for over 50% of deaths. There are currently no tools to identify patients at risk of developing metastasis. Circulating tumour cells (CTC) represent a transient cancer cell population in the blood. In this study, the researcher has developed CTC isolation methodologies and used novel culture formulations to expand patient derived CTCs for therapy testing. Furthermore, the researcher identified biomarkers present on CTCs which could select patients for immunotherapies, a current unmet need. This work sets the foundation for a personaliz

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4

Homer, Jarrod James. "Studies on angiogenesis in head and neck squamous cell carcinoma." Thesis, University of Hull, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342866.

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5

Chan, Chiu-lung Richie, and 陳肖龍. "Mucosal melanoma of the head and neck." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632876.

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6

Wimardhani, Yuniardini. "Molecular Detection Of Disseminated Tumour Cells In Blood And Lymph Nodes In Patients With Head And Neck Squamous Cell Carcinoma; Correlation With Clinical And Pathological Factors And Its Effect On Patients Outcome." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/5121.

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7

Zimmermann, Miriam. "The tumour microenvironment and response to therapeutic agents in head and neck squamous carcinoma cells." Thesis, University of London, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548044.

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8

Cheah, Ramsah. "Monitoring the response of head and neck tumour tissue to irradiation using a microfluidic-based approach." Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:13947.

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Radiotherapy remains the standard treat74ment for head and neck squamous cell carcinoma (HNSCC), however, resistance remains a real clinical problem despite the improvements and development of new treatment strategies. Patient outcome could potentially be improved if the response to irradiation could be predicted allowing alternative treatments to be implemented. The current project has investigated the ability to maintain HNSCC tissue under pseudo in vivo-like conditions using a bespoke microfluidic device. The interrogation of the tissue with irradiation has also been performed with a view t

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9

Boldrup, Linda. "p63 and potential p63 targets in squamous cell carcinoma of the head and neck." Doctoral thesis, Umeå : Univ, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1522.

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10

Andrews, Nigel Anthony. "Intrinsic cellular radiosensitivity in head and neck cancer." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367189.

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11

Hunter, Keith David. "Gene expression analysis of head and neck cancer development." Thesis, University of Glasgow, 2005. http://theses.gla.ac.uk/1712/.

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Microarray analysis was performed on 32 head and neck keratinocytes cultures using Affymetrix U133A/B genechips. The panel of cultures included normal cells, mortal and immortal cultures of dysplastic keratinocytes and mortal and immortal cultures from carcinomas, all grown to a standard protocol. The overall GEP revealed that many of the well-established HNSCC molecular markers associated with motility and invasion were up-regulated in the mortal cells, particularly in the mortal carcinomas. Immortal NHSCC cells showed elevated expression of cell-cycle markers and loss of differentiation mark

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12

Modasia, Bhavika. "PTTG, PBF and p53 in head and neck cancer." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7574/.

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Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and poses a significant health burden due to its rising incidence. The proto-oncogene PTTG is overexpressed in HNSCC and correlates with poor patient prognosis. A recent unpublished GEO profile eDNA array analysis has further suggested a potential upregulation of its binding partner PBF in HNSCC. PTTG and PBF cause transformation in vitro and tumour formation in vivo, both effects thought to be partly mediated by their interactions with the tumour suppressor protein p53. Dysregulation of the p53 pathway is fr

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13

Nordemar, Sushma. "Methods for early diagnosis of head and neck cancer /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-872-6/.

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14

Viblom, Jonathan, and Jonas Emauelsson. "Mandibular Reconstruction after Head and Neck Tumor Treatment, a Systematic Review." Thesis, Umeå universitet, Institutionen för odontologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97844.

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Objectives This systematic literature review examined the literature about mandibular reconstruction after cancer treatment with segmental resection, with focus on success rate for the reconstruction, patient survival rate, dental rehabilitation and how this effect the patients QOL, oral function and aesthetics. Material and methods A search was performed in Pubmed, a database of scientific articles, based on four keywords (Mandibular, Reconstruction, Cancer, Segmental). After screening using our inclusion and exclusion criteria’s, 89 articles were chosen. A data base in excel was establish

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15

Wilkie, Mark David. "Tumour metabolism in squamous cell carcinoma of the head & neck : consequences & potential therapeutic implications of TP53 mutation." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3021106/.

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Survival outcomes for traditional Human papillomavirus (HPV)-negative squamous cell carcinoma of the head and neck (SCCHN) have not improved significantly over the last 20-30 years. In contrast, HPV-positive oropharyngeal SCC is associated with favourable survival outcomes, but patients often suffer long-term functional ramifications from the toxicity of their treatment. Therefore, in the context of HPV-negative SCCHN there is a need to improve treatment efficacy to enhance survival outcomes, while for HPVpositive oropharyngeal SCC there is a need to minimise treatment-associated toxicity. Fun

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16

Moutasim, Karwan A. "Integrin avb6 : expression and function in head and neck cancer." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/374708/.

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17

Nestor, Marika. "Antibody-Based Radionuclide Targeting for Diagnostics and Therapy : Preclinical Studies on Head and Neck Cancer." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7341.

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18

Markkola, Antti. "Spin lock and magnetization transfer imaging of head and neck tumors." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/markkola/.

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19

Cheng, Junping. "Radioimmunotherapy in Experimental Head and Neck Squamous Cell Carcinoma : Tumour-targeting in vitro and in vivo." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5834.

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20

Snaddon, Jennifer A. M. "Molecular analysis of the tumour suppressor genes MXI1 and PTEN in human squamous cell carcinoma of the head and neck." Thesis, Glasgow Caledonian University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340609.

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21

Sylvester, Deborah Claire. "Development of micro fluidic based devices for studying tumour biology and evaluating treatment response in head and neck cancer biopsies." Thesis, University of Hull, 2011. http://hydra.hull.ac.uk/resources/hull:7087.

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Head and Neck Squamous Cell Carcinoma (HNSCC) presents particular challenges to both the researcher and the clinician. Encompassing a group of tumours with distinct epidemiological and oncological behaviour, each sub site differs greatly in its management and prognosis. However, due to insufficient tissue quantities and culture techniques, research studies commonly group together different sub sites, limiting our understanding of the biological behaviour and treatment response of tumours from distinct sites. Micro fluidics relates to the science of systems that process or manipulate small amou

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22

Recalde-Percaz, Leire. "Neuropilin 2 role in the regulation of disseminated tumour cells dormancy and metastasis in breast and head and neck cancer." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672374.

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Metastases are considered the last stage of tumour progression and the main cause of death associated to solid tumours. There are no effective treatments for metastasis which remain non- curable with more than 90% of patients dying from metastatic disease. They derive from disseminated tumour cells (DTCs) that can remain occult in a dormant state while adapting to the new microenvironment. By mechanisms that are still unclear, dormant DTCs can re-activate and become proliferative giving rise to metastatic outgrowth. Therefore, understanding the mechanisms by which metastases are formed is esse

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23

Bradburn, Jennifer Elizabeth. "Reactive species promotion of head and neck squamous cell carcinoma." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1166555968.

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24

Marcu, Loredana Gabriela. "Deterministic modelling of kinetics and radiobiology of radiation-cisplatin interaction in the treatment of head and neck cancers." Title page, contents and abstract only, 2004. http://hdl.handle.net/2440/37961.

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One of the main objectives of combining radiation treatment and chemotherapy is to obtain a therapeutic gain by an improved tumour control with less or no enhancement of normal tissue toxicity. The optimal schedule for the combined treatment of cisplatin-radiation is still under investigation. Neither the optimal time interval, nor the most adequate sequence of administration of cisplatin and radiation are known. The results of the trials are also inconclusive. Some trials showed a supra-additive effect from the administration of cisplatin before radiotherapy, others, on contrary, from the inj

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25

Haylock, Anna-Karin. "Targeting molecules for diagnostics of Head and Neck squamous cell carcinoma." Doctoral thesis, Uppsala universitet, Öron-, näs- och halssjukdomar, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-315210.

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To personalize treatment for cancer, correct staging of the primary tumor, nodal disease and metastatic disease is of essence. By targeting tumor specific receptors with radiolabeled antibodies, specificity and accuracy of imaging may be improved. Radio-immunodiagnostics can potentially detect small volume disease, occult metastasis and recurrent cancer in treated tissue. This thesis focuses on evaluation of radio-immunoconjugates directed towards CD44v6, which is a surface receptor overexpressed in many head and neck squamous cell carcinomas. At the outset, the monoclonal chimeric antibody cM

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26

Ekberg, Tomas. "Diagnosis and Radioimmunotherapy of Head and Neck Squamous Cell Carcinomas." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8395.

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27

Nutting, Christopher. "Can intensity-modulated radiotherapy (IMRT) be used to reduce toxicity and improve tumour control in patients with head and neck cancer?" Thesis, City University London, 2012. http://openaccess.city.ac.uk/1128/.

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Radiotherapy is commonly used in the treatment of head and neck cancer. For early stage tumours, conventional radiotherapy techniques have a high cure rate and low levels of long-term complications. Patients with more advanced cancers have much lower cure rates and high levels of treatment-related complications. Intensity modulated radiotherapy (IMRT) is a new form of focussed radiation therapy. It has been used to reduce the radiation dose to normal tissue structures and increase the dose delivered to tumour bearing tissues. This potentially allows reduced side effects and increased tumour co

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28

Lundmark, Martin. "Clinical evaluation of atlas-based segmentation for radiotherapy of head and neck tumours." Thesis, Umeå universitet, Institutionen för fysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45571.

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Background Semi-automated segmentation using deformable registration of atlases consisting of pre-segmented patient images can facilitate the tedious task of delineating structures and organs in patients subjected to radiotherapy planning. However, a generic atlas based on a single patient may not function well enough due to the anatomical variation between patients. Fusion of segmentation proposals from multiple atlases has the potential to provide a better segmentation due to a more complete representation of the anatomical variation. Purpose The main goal of the study was to investigate pot

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29

MISSALE, FRANCESCO. "Immune contexture monitoring in solid tumors focusing on Head and Neck Cancer." Doctoral thesis, Università degli studi di Brescia, 2023. https://hdl.handle.net/11379/570176.

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Forti evidenze dimostrano una stretta interazione tra il sistema immunitario e lo sviluppo biologico e la progressione clinica dei tumori solidi. L'effetto che il microambiente immunitario del tumore può avere sul comportamento clinico della malattia è indicato come "immunecontexture". Nonostante ciò, l'attuale gestione clinica dei pazienti affetti da cancro non tiene conto di alcuna caratteristica immunologica né per la stadiazione né per le scelte terapeutiche. Il tumore della testa e del collo (HNSCC) rappresenta il 7° tumore più comune al mondo ed è caratterizzato da una prognosi relativam

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30

Reid, Katherine Jane. "The experience of patients diagnosed and treated for head and neck cancer." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4333/.

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Head and neck cancer (H&NC) and its possible treatment options are diverse and multifaceted. This thesis demonstrates these complexities and describes three studies that have used different methodological approaches to include, rather than overlook these aspects. The first established which aspects of patients’ experiences are overlooked if health care professionals rely upon health related quality of life questionnaires to represent the experience of patients. The second identified that the multi-disciplinary team (MDT) working with the patients use humane judgement, not technical expertise,

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31

McCaul, James A. "Telomere function and the radiosensitivity of squamous carcinoma of the head and neck." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/4117/.

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This thesis considers whether the alteration of telomere function by manipulation of the telomerase enzyme can affect the radiosensitivity of in vivo derived SCCHN cells and hence whether telomere dysfunction inducing strategies are likely to be synergistic with ionising radiation in the management of SCCHN. The role of telomerase in radioprotecting cancer cells is investigated using the ectopic expression of hTERT in cell lines with high and low levels of telomerase. The effect of inhibiting telomerase expression is examined using a dominant negative telomerase gene. This approach had little

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32

Forootan, Shiva Seyed. "Neoangiogenesis in squamous cell carcinoma of head and neck in relation to basic fibroblast growth factor." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367196.

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Lara, Ana. "FDG tumor volumetric parameters and outcome in lung cancer and head and neck cancer." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12464.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Lung cancer (LC) is the leading cause of cancer mortality worldwide and second most common type of cancer in the United States in both genders. Moreover, Head and neck cancer (HNC) is the sixth most common cance

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34

Baboci, Lorena. "Human papillomavirus - associated head and neck squamous cell carcinomas in North-East Italy." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423688.

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Background: Specific oncogenic types of human papillomaviruses (HPV), most frequently HPV16, are causally associated with a subset of head and neck squamous cell carcinomas (HNSCC). HPV DNA associated tumors appear to be heterogeneous in prevalence over time and geographically, in the oncogenic activity (direct and indirect viral markers) and clinical behavior. However, it remains unclear which biomarkers can reliably determine which HNSCC are truly driven by HPV transformation. Aims: In the present thesis, the first aim was to determine the prevalence of the truly HPV-associated HNSCC tumors

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35

Paccione, Rachel J. "Vimentin Overexpression Contributes To the Biological Properties of Metastatic Head and Neck Cancer Cells." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/1084.

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Epithelial to mesenchymal transition occurs in the later stages of epithelial tumor progression, with cells expressing mesenchymal markers. Of these, the intermediate filament protein vimentin is frequently upregulated in metastatic carcinomas. Previously, microarray studies showed that the gene encoding vimentin is highly upregulated in metastatic HN12 cells compared to a related primary tumor cell line. In this study, we confirmed this difference using real-time quantitative PCR, western blot analysis, and immunostaining. Furthermore, EGF and TGF-β, growth factors that induce migration and i

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36

Hoffmann, Caroline. "Dendritic Cells in Head and Neck Cancer Microenvironment : From Mechanisms to Biomarkers." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS308/document.

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L’objectif de ce travail était de comprendre l’état moléculaire des cellules dendritiques (CD) dans le microenvironnement tumoral. En intégrant l’analyse de tumeurs humaines par cytométrie en flux, de transcriptome, de secretome tumoral et l’analyse d’une base de données d’interaction CD-lymphocyte T générées in vitro, j’ai obtenus 2 résultats majeurs. Tout d’abord, nous proposons une nouvelle classification de CD activées humaines, qui sont soit « secrétantes », c’est-à-dire spécialisées dans la production de cytokines et chemokines, soit « aidantes » c’est-à-dire spécialisées dans l’inductio

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37

Berthon, Beatrice. "Optimisation of Positron Emission Tomography based target volume delineation in head and neck radiotherapy." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/69184/.

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Automatic segmentation of tumours using Positron Emission Tomography (PET) was recommended for radiotherapy treatment (RT) planning of head and neck (H&N) cancer patients, and investigated in the scientific literature without reaching a consensus on the optimal process. This project aimed at evaluating the performance of PETCbased automatic segmentation (PETCAS) methods and developing an optimal PETC AS process to be used at Velindre Cancer Centre (VCC). For this purpose, ten algorithms were implemented to represent the most promising PETCAS approaches from a systematic review of the literatur

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38

Cupparo, Ilaria. "Region growing and fuzzy C-means algorithm segmentation for PET images of head-neck tumours." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18020/.

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The aim of this work, performed at Azienda Ospedialiero Universitaria in Modena, is the implementation and validation of autosegmentation methods of head and neck (H&N) tumor PET images. These autosegmentation processes are important mostly to overcome the problems of manual segmentation, performed by radiotherapist physician, regarding the contouring time (that can reach more than two hours) and the intra-observer and inter-observer variability. Fuzzy C-means (FCM) and Region Growing (RG) algorithms were developed in a MATLAB GUI that allows to choice iteratively the different steps necessary

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Cafaro, Alexandre. "AI-Driven Adaptive Radiation Treatment Delivery for Head & Neck Cancers." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL103.

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Le cancer de la tête et du cou (HNC) est l'un des cancers les plus difficiles à traiter en raison de la complexité de son anatomie et des changements significatifs spécifiques à chaque patient au cours du traitement. En tant que 6e cancer le plus fréquent dans le monde, le HNC présente souvent un mauvais pronostic en raison d'un diagnostic tardif et de l'absence de marqueurs prédictifs fiables. La radiothérapie, souvent associée à la chirurgie, est confrontée à des défis tels que la variabilité inter-observateur, la complexité de la planification et les changements anatomiques pendant le trait

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40

Hakelius, Malin. "Interactions between Malignant Keratinocytes and Fibroblasts : Studies in Head and Neck Squamous Cell Carcinoma." Doctoral thesis, Uppsala universitet, Plastikkirurgi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-221109.

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Carcinoma growth requires a supportive tumor stroma. The concept of reciprocal interactions between tumor and stromal cells has become widely acknowledged and the connective tissue activation seen in the malignant process has been likened to that of a healing wound. Little is, however, known about the specific characteristics of these interactions, distinguishing them from the interplay occurring between epithelial and stromal cells in wound healing. In order to study differences in the humoral effects of malignant and benign epithelial cells on fibroblasts, we used an in vitro coculture model

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Dahlgren, Liselotte. "Studies on the presence and influence of human papillomavirus (HPV) in head and neck tumors /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-289-6/.

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42

Ansell, Anna. "Identification of Tumor Cell- and Stroma Derived Biomarkers of Treatment Response in Head and Neck Cancer." Doctoral thesis, Linköpings universitet, Avdelningen för neurovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-100734.

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Head and neck squamous cell carcinoma (HNSCC) poses a major health problem in the world with approximately 600 000 new cases yearly. Treatment resistance is a major problem within this patient group and despite advances in treatment strategies the overall survival rate has unfortunately not increased. One of the major components of the tumor microenvironment is the cancer associated fibroblasts (CAFs) which can modulate the treatment sensitivity, tumor growth, and the invasive potential of tumor cells. The aim of this thesis was to identify predictive markers for treatment response in HNSCC an

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43

Macedo, Gonzales Rodney. "Development of therapeutic vaccine strategies and pre-clinical animal tumor models for head and neck cancers." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066269/document.

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Les cancers des voies aéro-digestives supérieures, liés à la consommation d'alcool et de tabac mais également à l'HPV-16, ont un pronostic médiocre malgré les traitements actuels. Le développement de nouvelles stratégies innovantes dans des modèles précliniques adaptés est ainsi nécessaire. Nous avons préalablement développé une stratégie vaccinale ADN permettant l'auto-assemblage in vivo de pseudo-particules virales non infectieuses exprimant l'oncoprotéine E7 de l'HPV-16 (pVLP-E7). Nous avons notamment montré que l'injection de pVLP-E7 en intradermique (ID) était capable d'induire de bonnes

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Gillgren, Peter. "Body site of cutaneous malignant melanoma : primary tumor location in relation to phenotypic and prognostic factors /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-339-2.

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45

Aslam, Mohammed Afeef. "An investigation of GRP78 expression and inhibition in squamous cell carcinoma of the head and neck." Thesis, University of Liverpool, 2011. http://livrepository.liverpool.ac.uk/3813/.

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GRP78 is a known cyto-protective gene which is induced in microenvironments typical of tumours with low glucose and hypoxia. Furthermore up-regulation of GRP78 has been linked to chemo- and radioresistance as well as poor survival outcome. This study is the first to confirm that GRP78 is up-regulated in tumours of the oropharynx, larynx and hypopharynx compared with matched histologically normal tissue (p(Χ2)<0.001). Up-regulation of GRP78 may be important for tumour development and therefore we have investigated the consequences of inhibition of GRP78 in cells derived from laryngeal squamous

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46

Cederblad, Lena. "Aspects on Head and neck Cancer with special reference to Salivary Gland Tumours and Single Nucleotide Polymorphism." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-332192.

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A thesis on Head and neck cancer focusing on dose planning, salivary gland carcinoma and Single nucleotide polymorphism. For dose planning PET/CT (Positron emissions tomography/computed tomography) with tracer gave more precise information in comparison dose planning with CT. More primary tumours and metastases were found with the acetate tracer than with glucose tracer. Acetate PET/CT also showed larger volume of tumours attributed to lipid metabolism. In a retrospective study salivary gland cancer 5-year overall survival (OS) was 53 %. Salivary gland carcinoma consists of many histopathologi

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47

Dounis, Evangelia. "Effect of irradiation of head and neck tumours on the proteins' composition of the enamel salivary pellicle." [S.l. : s.n.], 2004. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11163744.

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Dong, Lixin. "DIFFUSE OPTICAL MEASUREMENTS OF HEAD AND NECK TUMOR HEMODYNAMICS FOR EARLY PREDICTION OF CHEMO-RADIATION THERAPY OUTCOMES." UKnowledge, 2015. http://uknowledge.uky.edu/cbme_etds/35.

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Chemo-radiation therapy is a principal modality for the treatment of head and neck cancers, and its efficacy depends on the interaction of tumor oxygen with free radicals. In this study, we adopted a novel hybrid diffuse optical instrument combining a commercial frequency-domain tissue oximeter (Imagent) and a custom-made diffuse correlation spectroscopy (DCS) flowmeter, which allowed for simultaneous measurements of tumor blood flow and blood oxygenation. Using this hybrid instrument we continually measured tumor hemodynamic responses to chemo-radiation therapy over the treatment period of 7

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Maxim, Nicolas T. Mr. "Tumor-Specific Cell Death Induction by Noxa Overexpression for Head and Neck Squamous Cell Carcinoma (HNSCC) Treatment." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4230.

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The primary focus of this research is the mechanisms of cell death in head and neck squamous cell carcinoma (HNSCC) treatment. These cancers typically originate in squamous cells that line the moist mucosal surfaces of head and neck. HNSCC is commonly treated with a platinum based agent, cisplatin. While the drug does offer strong antitumor effects, its prolonged use often results in tumor-acquired resistance, which limits treatment effectiveness. We have shown that cisplatin treatment induces the expression of a pro-apoptotic BCL-2 family member Noxa, which then initiates caspase- dependent a

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CHITI, LAVINIA ELENA. "GAMMA-PROBE GUIDED SENTINEL LYMPH NODE EXTIRPATION TO ASSESS PATTERNS OF NODAL METASTASIS IN SPONTANEOUS HEAD AND NECK MALIGNANCIES OF THE DOG: A SECOND STEP BASED ON PREVIOUS EXPERIENCES ON MAST-CELL TUMORS." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/916665.

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Canine oncology has recently reported interest in the detection of occult nodal metastases, and efforts have been made to identify the best strategy for accurate nodal staging. In this scenario, the present PhD thesis was aimed to improve knowledge on the current understanding of the feasibility and impact of sentinel lymph node (SLN) mapping with radiopharmaceutical and blue dye in cancer-bearing dogs. Initially, we evaluated the technique in canine mast cell tumors (MCT), given the high prevalence of this tumor type, the propensity for lymphatic spread and recognized prognostic impact of nod

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