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Bibliographies thématiques / Hemopoietic stem cell transplantation / Thèses

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Thèses sur le sujet « Hemopoietic stem cell transplantation »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Sutherland, Heather Jeanine. "Purification and characterization of the human hemopoietic stem cell." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/32010.

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Previous studies in mice have suggested that some if not all hemopoietic stem cells with long-term in vivo repopulating ability are biologically, physically, and pharmacologically different from cells detectable by short-term colony assays. Since human hemopoietic stem cells cannot be assessed by expression of their in vivo repopulating potential, characterization of these cells requires an alternative endpoint. This thesis explores the use of clonogenic cell production in vitro in the presence of a competent stromal cell feeder layer for this purpose, based on the observation that this can co

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Goodman, Reyna Suzanne. "Immunogenetics of haematopoietic stem cell transplantation." Thesis, Anglia Ruskin University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478885.

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3

Kahatapitiya, Prathibha C. "Enrichment of skeletal muscle stem cell transplantation using chemotherapeutic drugs a paradigm for enhanced stem cell transplantation /." Connect to full text, 2008. http://hdl.handle.net/2123/4050.

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Thesis (Ph. D.)--University of Sydney, 2009.<br>Title from title screen (viewed Apr. 24, 2008) Title from title screen (viewed Feb. 18, 2009) Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Discipline of Paediatrics and Child Health, Faculty of Medicine. Degree awarded 2009 ; thesis submitted 2008. Includes bibliographical references. Also available in print form.

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4

Szeto, Ching-ho. "Late complications of haemopoietic stem cell transplantation." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972184.

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5

Trolle, Carl. "Stem Cell Transplantation in Dorsal Root Injury." Licentiate thesis, Uppsala universitet, Institutionen för neurovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-218686.

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After traumatic injuries to the brachial plexus there is a risk that one or more of the spinal roots are torn from the spinal cord, known as avulsion injury. This often leads to paralysis and chronic pain, notoriously difficult to treat with current pharmacotherapy. Surgical treatment may improve motor function but sensory recovery is usually poor as sensory axons fail to establish functional connections inside the spinal cord. The aims of this thesis were to develop a model for dorsal root avulsion in rodents in order to investigate the potentials of stem cell therapy for enhancing sensory re

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6

Szeto, Ching-ho, and 司徒精豪. "Late complications of haemopoietic stem cell transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972184.

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7

Li, Pulin. "Chemical Genetics of Hematopoietic Stem Cell Transplantation." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10306.

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Hematopoietic stem and progenitor cells (HSPCs) repopulate the blood system upon transplantation. A large-scale genetic approach to understand the factors that participate in successful engraftment has not been undertaken. In this thesis, I present the development of a novel live imaging-based competitive marrow repopulation assay in adult zebrafish, which allows fast and quantitative measurement of HSPC engraftment capability. Using this assay, a transplantation-based chemical screen was performed, which led to the discovery of 10 compounds that can enhance the marrow engraftment capability i

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8

Atarod, Sadaf. "MicroRNAs in haematopoietic stem cell transplantation outcome." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2936.

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Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous haematological malignancies. Graft-versus-host disease (GVHD) is the major complication causing mortality and is classified into acute (aGVHD) and chronic. MicroRNAs play a significant role in inflammation and have reported potential as biomarkers of different diseases. This study has investigated the role of microRNAs in allo-HSCT outcomes and had two main aims; (1) identification of microRNAs specific to the aGVHD target organ, skin and (2) an investigation into the role of immune specific mi

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9

Lau, Ka-kit George. "Hepatitis B infection and hematopoietic stem cell transplantation." Click to view the E-thesis via HKUTO, 1999. http://sunzi.lib.hku.hk/hkuto/record/B31981756.

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10

Omazic, Brigitta. "Immune reconstitution after allogeneic hematopoietic stem cell transplantation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-117-2/.

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11

Nadal-Melsio, Elisabet. "Regulatory T cells after allogeneic stem cell transplantation." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523746.

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Lau, Ka-kit George, and 廖家傑. "Hepatitis B infection and hematopoietic stem cell transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31981756.

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13

Tassoni, Alessia. "Retinal glial responses to mesenchymal stem cell transplantation." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709042.

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14

João, Cristina Maria Pires. "Immune reconstitution after autologous hematopoietic stem cell transplantation." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2007. http://hdl.handle.net/10362/5158.

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Abstract The investigation of the web of relationships between the different elements of the immune system has proven instrumental to better understand this complex biological system. This is particularly true in the case of the interactions between B and T lymphocytes, both during cellular development and at the stage of cellular effectors functions. The understanding of the B–T cells interdependency and the possibility to manipulate this relationship may be directly applicable to situations where immunity is deficient, as is the case of cancer or immune suppression after radio and chemot

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15

Onda, Yoshiyuki. "Adenovirus infection after allogeneic hematopoietic stem cell transplantation." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265191.

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京都大学<br>新制・課程博士<br>博士(医学)<br>甲第23419号<br>医博第4764号<br>新制||医||1052(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授滝田順子, 教授杉田昌彦, 教授朝長啓造<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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16

Mavin, Emily. "Regulatory T cells in haematopoietic stem cell transplantation." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2731.

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Graft-versus-host disease (GvHD) remains the main complication associated with haematopoietic stem cell transplantation (HSCT). GvHD is caused by allo-reactive donor T cells mounting an attack against specific target tissues. CD4+CD25HiFoxp3+ regulatory T cells have been shown to modulate GvHD in vitro and also in vivo animal models. More recently early stage clinical trials have described the successful use of Treg to reduce the incidence of GvHD following HSCT. The aim of this study was to investigate further the suppressive mechanisms by which Treg are able to modulate GvHD and assess the i

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17

Abraham, Samuel D. M. "Activation of multiple hemopoietic growth factor genes in Abelson virus transformed myeloid cells." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27786.

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The stringent requirement for hemopoietic growth factors (HGF) in the induction of hemopoiesis in vitro has raised questions as to their possible role(s) in leukemogenesis. Several recent clinical studies have shown aberrant cell growth factor gene activation in patient derived leukemic cells. Assessment of growth factor activity is often based on in vitro bioactivity assays of conditioned media or body fluids. The specificity of this type of endpoint is, however, open to question due to the overlap in biological activities of many HGFs. In assessing the role of growth factor gene expression

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18

Jansson, Monika. "Detection of donor cells in recipient tissues after stem cell transplantation using FISH and immunophenotypi Stem cell transplantationng /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-222-4/.

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19

Prieto, Hinojosa A. I. "T cell subsets and the outcome of haematopoietic stem cell transplantation." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1355324/.

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Haematopoietic stem cell transplantation (HSCT) is an effective therapy for many malignant and non‐malignant diseases. However, adverse events such as infections, Graft‐versus‐Host Disease (GvHD) and relapse limit the wider use of HSCT. The identification of factors that predict the outcome of the transplant can be a vital tool to offer patients better options for treatment. Since there is a significant immunological contribution to the outcome of the transplant, it is of interest to ask to what extent the immune status of the patient prior to transplant might influence their subsequent recove

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20

Xiong, Ying. "Immuno-Magnetic T Cell Depletion For Allogeneic Hematological Stem Cell Transplantation." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1205852981.

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21

Okas, Mantas. "Novel immunotherapeutical strategies in allogeneic hematopoietic stem cell transplantation /." Stockholm : Department of laboratory medicine, Karolinska institutet, 2010. http://diss.kib.ki.se/2010/978-91-7409-934-8/.

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22

Cho, Candice. "Factors affecting stem cell transplantation for leukemia and lymphoma." CONNECT TO ELECTRONIC THESIS, 2006. http://hdl.handle.net/1961/3595.

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23

Cahill, Kevin Scott. "Enhancement of stem-cell transplantation strategies for muscle regeneration." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0002319.

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24

Wang, Fu-Zhang. "Human herpesvirus 6 infection after allogeneic stem cell transplantation /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3589-0/.

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25

Remberger, Mats. "Cytokine production in allogeneic haematopoietic stem-cell transplantation patients /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3749-4/.

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26

Wennersten, Andrʹe. "Human neural stem cell transplantation in experimental brain trauma /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-211-X/.

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27

Petropoulos, Antonios. "Assessment of pharmacogenetic polymorphisms in haematopoietic stem cell transplantation." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515029.

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28

König, Niclas. "Reconnecting the CNS and PNS with Stem Cell Transplantation." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251546.

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Severe injury may result in disconnection between the peripheral and central nervous system. Regeneration of the central portion of sensory neurons into the spinal cord is notoriously poor in adult mammals, with low regenerative drive and an unpermissive central environment, most likely resulting in persistent loss of sensory function. A variety of strategies have been addressedto augment regeneration, including application of growth promoting factors, counteraction of inhibitory molecules, and provision of growth permissive substrates. Stem cells have been investigated in these contexts, as w

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29

Mehat, M. S. "Investigation of stem cell-derived retinal pigmented epithelium transplantation." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1540121/.

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Retinal pigment epithelium (RPE) cells perform a variety of roles that are principally directed at maintaining retinal function and homeostasis and their loss causes conditions such as age-related macular degeneration (AMD) and Stargardt disease (STGD). Regeneration of the loss or dystrophic RPE cells with stem cell-derived RPE may provide a potential therapeutic option. STGD is the commonest form of juvenile-onset, inherited macular degeneration. In order to determine the safety and efficacy of embryonic stem (ES) cell-derived RPE transplantation for the treatment of STGD, twelve subjects wit

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30

McLarnon, Andrew. "Cellular mechanisms of alloreactive immunity following stem cell transplantation." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3064/.

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Allogeneic stem cell transplantation is associated with a powerful T cell-mediated ‘graft-versus-leukaemia’ (GvL) effect and also ‘graft-versus-host disease’ (GvHD). Developing therapies to improve survival relies on greater understanding of these responses in order to enhance GvL and suppress GvHD. To gain an increased understanding of the mechanisms of GvHD I measured frequencies of Th1, Th17 and Treg subsets in the blood of 32 GvHD patients (during and outside of disease episodes) and in 21 patients who did not suffer GvHD. No associations between T cell subset frequencies or serum cytokine

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31

Trolle, Carl. "Stem cell transplantation and regeneration after dorsal root avulsion." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265853.

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Spinal root avulsion leads to paralysis and loss of sensory function. Surgical methods can improve motor function and ameliorate pain but sensory recovery in adults is poor. Previous studies have shown that cell transplantation or treatment with trophic factors can improve functional outcome in rodents after dorsal root transection or crush. Here, a dorsal root injury model, more similar to human avulsion injuries, was used. The aims of this thesis were to investigate the behaviour of different stem cells following transplantation to avulsed dorsal roots and asses their potential to serve as p

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32

Singh, Mandeep S. "Regeneration of the retina by stem cell transplantation therapy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:e1fdf35f-fb1e-42a0-8a81-9876f0151eea.

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One strategy to restore vision in retinitis pigmentosa and related retinal degenerations is by cell replacement. Typically, patients lose vision when the outer retinal photoreceptor layer is lost, and so the therapeutic ideal would be to restore vision at this stage of disease. It is not currently known if a degenerate retina lacking the outer nuclear layer of photoreceptor cells would allow the survival, maturation and reconnection of replacement photoreceptors, as prior studies used hosts with a pre-existing outer nuclear layer at the time of treatment. Here, using a murine model of severe h

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33

Kanda, Junya. "Analysis of serum hepcidin in hematopoietic stem cell transplantation." Kyoto University, 2010. http://hdl.handle.net/2433/120544.

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Ren, Song. "Metabolism of cyclophosphamide : implications for hematopoietic stem cell transplantation /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7968.

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35

O'Brien, Stephen Gerard. "Haemopoietic stem cell purging in chronic myeloid leukaemia." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300928.

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36

Kemp, Kevin Charles. "The role of mesenchymal stem cells in stem cell transplantation for haematological malignancies." Thesis, University of the West of England, Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495521.

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Haemopoietic recovery after high dose chemotherapy (HOC) in the treatment of haematological disease may be slow and/or incomplete. This is generally attributed to progressive haemopoietic stem cell failure, however we hypothesize that HOC induced defective haemopoiesis may be in part due to poor stromal function. Although chemotherapy is known to damage mature bone marrow stromal cells in-vitro, the extent to which marrow mesenchymal stem cells (MSC) are damaged by HOC in-vivo and in-vitro is unknown. To firstly address this question the physical characteristics and functional properties of ma

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37

Vicario, Nunzio. "Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/4088.

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Despite the remarkable beneficial effects of disease-modifying agents in relapsing-remitting multiple sclerosis (MS) patients, progressive forms of (P)MS still lack effective treatments. This stark contrast is partially dependent on the difficulties researchers have found in tackling the complex pathophysiology of this phase of disease, in which chronic inflammation within the central nervous system (CNS) is coupled by ongoing neurodegeneration and demyelination. Cell transplantation is among the most promising therapeutic approaches in regenerative medicine, combining tissue trophic and immun

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38

Hamou, Wissam. "Assessing liver regeneration by human embryonic stem cell-derived hepatocytes." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066374.

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Trouver de nouvelles sources de foie pour les transplantations est un vrai enjeu. Les obstacles principaux à la transplantation d'organes sont la pénurie de greffons et les lourds traitements immunosuppresseurs à vie. La possibilité de reprogrammer les cellules du patient et les cultiver donne accès à une quantité virtuellement illimitée de cellules a transplanter, éliminant de ce fait le besoin de donneurs d'organesMon doctorat se divise en deux parties : la première consiste à faire des cellules hépatiques en programmant des cellules souches humaines. La deuxième consiste à transplanter ces

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39

Powell, Robin H. "Characterization and Transplantation of Felid Spermatogonial Stem Cells." ScholarWorks@UNO, 2015. http://scholarworks.uno.edu/td/2011.

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Spermatogonial stem cells (SSC) self-renew and differentiate into spermatozoa throughout the life of the male. SSC transplantation is a potential method for the propagation of genetically important males. These cells have been isolated in different mammalian species using specific cell surface markers, but not in felines. The goal of this study was to explore a relevant strategy for conservation of endangered felids by characterizing domestic cat (Felis catus) SSCs and assessing their ability for self-renewal after transplantation. Firstly, SSC and pluripotent surface markers, identified in no

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40

Schaffer, Marie. "HLA and KIR gene polymorphism in hematopoietic stem cell transplantation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-836-3/.

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41

Broers, Anna Elisabeth Clasine. "Interleukin-7 and hematopoietic stem cell transplantation: beyond the thymus." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10697.

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42

McNicholl, Feargal Patrick. "Development of DNA vaccines for patients following stem cell transplantation." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432035.

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43

Wang, Hong. "Commercialization of Hematopoietic Stem Cell Expansion System For Clinical Transplantation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1300752742.

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Heemskerk, Bianca. "Adenovirus infection and immunity in children after stem cell transplantation /." Leiden, 2005. http://catalogue.bnf.fr/ark:/12148/cb40223278f.

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Hull, Katrusha. "Oral Long-Term Complications of Allogeneic Haematopoietic Stem Cell Transplantation." Thesis, Faculty of Dentistry, 2010. http://hdl.handle.net/2123/5930.

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46

Kahatapitiya, Prathibha Chathurani. "Enrichment of skeletal muscle stem cell transplantation using chemotherapeutic drugs." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/4050.

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The BCNU + O6benzylguanine (O6BG) driven selective enrichment strategy was first established for enhanced transplantation of hematopoietic stem cells. This study describes a novel application of this BCNU + O6BG driven selective enrichment strategy in skeletal muscle stem cell transplantation. Furthermore, this study addresses the three main limitations observed in previously reported skeletal muscle stem cell transplantation strategies. Limitation of ineffective donor cells which lack the ability for successful engraftment was overcome by using a heterogeneous population of donor cells which

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Kahatapitiya, Prathibha Chathurani. "Enrichment of skeletal muscle stem cell transplantation using chemotherapeutic drugs." University of Sydney, 2009. http://hdl.handle.net/2123/4050.

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Doctor of Philosophy (PhD)<br>The BCNU + O6benzylguanine (O6BG) driven selective enrichment strategy was first established for enhanced transplantation of hematopoietic stem cells. This study describes a novel application of this BCNU + O6BG driven selective enrichment strategy in skeletal muscle stem cell transplantation. Furthermore, this study addresses the three main limitations observed in previously reported skeletal muscle stem cell transplantation strategies. Limitation of ineffective donor cells which lack the ability for successful engraftment was overcome by using a heterogeneous po

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48

Marzollo, Antonio. "Hematopoietic stem cell transplantation in children with non-malignant disorders." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427148.

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Hematopoietic Stem Cell Transplantation (HSCT) is a curative option for specific non-malignant disorders in childhood, including hemoglobinopathies and primary immune deficiencies. Despite promising results in the recent years, many issues regarding timing of HSCT, donor selection, conditioning regimen and post-transplant care are currently open. Here, a cohort of 11 patients with Sickle Cell Disease transplanted after a Treosulfan-based conditioning regimen is described showing that this approach is suitable also when alternative donors are employed. Optimal modalities for HSCT in patient

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49

Uzunel, Mehmet. "The methodology and significance of minimal residual disease detection after allogeneic stem cell transplantation /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-619-7.

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Chiereghin, Angela <1982&gt. "Epstein-Barr Virus-Related B Cell Lymphoproliferative Disorder After Hematopoietic Stem Cell Transplantation." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7611/1/Chiereghin_Angela_Tesi.pdf.

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In 51 (33 adult-18 paediatric) allogeneic hematopoietic stem cell transplant recipients we aimed to evaluate: i) the incidence of EBV infection and potential risk factors; ii) the suitability of whole blood (WB) as clinical specimen to monitor the risk of patients to develop EBV-related post-transplant lymphoproliferative disorder (EBV-PTLD); iii) the clinical utility of combined virological-immunological monitoring; iv) the management of infection and the incidence of EBV-PTLD. Quantitative real-time PCR assay was performed on WB samples for all patients. EBV-DNA quantification also in peri

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