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1

Reipert, S., J. A. Hickman, and T. D. Allen. "DNA inclusions within autolytic cytoplasmic vacuoles of hemopoietic stem cell line FDCP-Mix." Journal of Histochemistry & Cytochemistry 44, no. 6 (1996): 549–58. http://dx.doi.org/10.1177/44.6.8666740.

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FDCP-Mix, a pluripotent routine hemopoietic stem cell line undergoes internucleosomal cleavage of DNA when induced to apoptosis either by drugs or by withdrawal of growth factor (IL-3), and also displays a pattern of nuclear morphology that is typical for apoptosis. However, increased autolytic activity in the cytoplasm precedes the nuclear changes. For etoposide-treated FDCP-Mix cells, mitochondria were identified as a target for autolytic digestion in large autolytic vacuoles, but during this period an increase in the number of mitochondria was observed. The autolytic vacuoles displayed vari
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Kajigaya, S., T. Suda, J. Suda, et al. "A recombinant murine granulocyte/macrophage (GM) colony-stimulating factor derived from an inducer T cell line (IH5.5). Functional restriction to GM progenitor cells." Journal of Experimental Medicine 164, no. 4 (1986): 1102–13. http://dx.doi.org/10.1084/jem.164.4.1102.

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The cDNA for the murine granulocyte/macrophage colony-stimulating factor (GM-CSF) was cloned from a cDNA library obtained from a murine T cell line, IH5.5, by using two synthetic probes that encoded two parts of the GM-CSF from murine lung. The cDNA inserted into the plasmid vector pcDV1 was transfected into monkey COS-1 cells and the conditioned medium was used to investigate the hemopoietic activities of the resultant product, recombinant GM-CSF (rGM-CSF), by means of various colony assays. rGM-CSF stimulated only neutrophil/macrophage colonies in the cultures of murine normal bone marrow an
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Bauvois, B., S. Ezine, B. Imhof, M. Denoyelle, and J. P. Thiery. "A role for the thymic epithelium in the selection of pre-T cells from murine bone marrow." Journal of Immunology 143, no. 4 (1989): 1077–86. http://dx.doi.org/10.4049/jimmunol.143.4.1077.

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Abstract A rat thymic epithelial cell line IT45-R1 has been previously described as secreting soluble molecules that in vitro chemoattract rat hemopoietic precursor cells. The development of such an in vitro migration assay was based on the ability of cells to migrate across polycarbonate filters in Boyden chambers. In the present paper, by using the same strategy, we studied murine bone marrow cells capable of migrating in vitro toward IT45-R1 conditioned medium. The responding cells were shown to represent a minor bone marrow subpopulation characterized by a low capacity to incorporate triti
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Srinivas, G., D.V. Ramanjaneyulu, E. Muralinath, et al. "An Essential Parameters of Importance of Stem Cells in Modern Medicine Include Examples of Stem Cells Therapies in Medicine, Neuro Degenerative Diseases and Pharmacological Testing." Research and Reviews in Intensive and Critical Care Nursing 3, no. 2 (2025): 1–12. https://doi.org/10.5281/zenodo.15355227.

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<em>The goal of the multidisciplinary discipline of regenerative medicine is to restore normal function by creating, replacing, or repairing damaged or lost cells, tissues, and organs, especially during illness. By altering a patient's cells, cell-based therapies&mdash;specifically, the therapeutic use of stem cells&mdash;offer a contemporary and exciting approach to regenerative medicine that may help heal a variety of illnesses.</em>
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Prosser-Dombrowski, Alexandra, John Perry, Irina Pushel, et al. "448 Unraveling the pathogenicity of a novel variant in Diamond Blackfan anemia." Journal of Clinical and Translational Science 9, s1 (2025): 132. https://doi.org/10.1017/cts.2024.1045.

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Objectives/Goals: Diamond Blackfan anemia (DBA) is caused by loss of ribosomal proteins leading to death of red blood cell progenitors. We identified a novel heterozygous variant (c.167+769C&gt;T) in RPL30 in a patient with DBA. We hypothesized that this variant, in a gene not previously studied in DBA, would demonstrate DBA phenotype and reveal early drivers of disease. Methods/Study Population: To study the role of our novel variant, we developed an induced pluripotent stem cell (iPSC) model, including wild type (WT) and CRISPR-edited RPL30 mutant clones. We differentiated the iPSC into hema
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6

Doi, H., M. Inaba, Y. Yamamoto, et al. "Pluripotent hemopoietic stem cells are c-kit." Proceedings of the National Academy of Sciences 94, no. 6 (1997): 2513–17. http://dx.doi.org/10.1073/pnas.94.6.2513.

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Liting, Song, and Goldman Emanuel. "Induced pluripotent stem cells are induced pluripotent stem cell-like cells." Journal of Biomedical Research 29, no. 1 (2015): 1. http://dx.doi.org/10.7555/jbr.29.20140166.

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Prosser, Alexandra, Irina Pushel, Chris Seidel, et al. "Stem Cell Model of Novel RPL30 Variant in Diamond Blackfan Anemia with Downregulated GATA1-HSP70 in Early Erythroid Progenitors." Blood 144, Supplement 1 (2024): 2710. https://doi.org/10.1182/blood-2024-208147.

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Introduction: Diamond Blackfan anemia (DBA) is caused by ribosomal protein gene mutations leading to increased apoptosis of erythroid progenitors. We identified a novel heterozygous variant (c.167+769C&amp;gt;T) in the noncoding region of RPL30 in a patient diagnosed with DBA. RPL30 variants have not been reported in DBA, although the gene is predicted to be intolerant to loss of function. We hypothesized that this variant would negatively impact ribosomal biogenesis, specifically in early erythroid progenitors. Methods: To study the role of our novel variant, we developed an induced pluripote
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El-Sayes, Abdullah. "Induced Pluripotent Stem Cells." Sciential - McMaster Undergraduate Science Journal, no. 1 (November 25, 2018): 16–22. http://dx.doi.org/10.15173/sciential.v1i1.1908.

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The isolation of human embryonic stem cells in 1998 has since fueled the ideology that stem cells may eventually be used for human disease therapies as well as the regeneration of tissues and organs. The transformation of somatic cells to a pluripotent state via somatic nuclear transfer and embryonic stem cell fusion brought the scientific community nearer to understanding the molecular mechanisms that govern cellular pluripotency. In 2006, the first induced pluripotent stem (iPS) cell was reported, where a mouse somatic cell was successfully converted to a pluripotent state via transduction o
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Chang, Chia-Yu, Hsiao-Chien Ting, Ching-Ann Liu, et al. "Induced Pluripotent Stem Cells." Cell Transplantation 27, no. 11 (2018): 1588–602. http://dx.doi.org/10.1177/0963689718775406.

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Many neurodegenerative diseases are progressive, complex diseases without clear mechanisms or effective treatments. To study the mechanisms underlying these diseases and to develop treatment strategies, a reliable in vitro modeling system is critical. Induced pluripotent stem cells (iPSCs) have the ability to self-renew and possess the differentiation potential to become any kind of adult cell; thus, they may serve as a powerful material for disease modeling. Indeed, patient cell-derived iPSCs can differentiate into specific cell lineages that display the appropriate disease phenotypes and vul
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11

Hynes, K., D. Menichanin, R. Bright, et al. "Induced Pluripotent Stem Cells." Journal of Dental Research 94, no. 11 (2015): 1508–15. http://dx.doi.org/10.1177/0022034515599769.

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Shevchenko, A. I., S. P. Medvedev, N. A. Mazurok, and S. M. Zakian. "Induced pluripotent stem cells." Russian Journal of Genetics 45, no. 2 (2009): 139–46. http://dx.doi.org/10.1134/s1022795409020021.

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Schenke-Layland, Katja, and W. Robb MacLellan. "Induced Pluripotent Stem Cells." Circulation 120, no. 15 (2009): 1462–64. http://dx.doi.org/10.1161/circulationaha.109.898544.

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Moussa, Manal Hassan. "Induced pluripotent stem cells." Egyptian Journal of Histology 34, no. 4 (2011): 621–24. http://dx.doi.org/10.1097/01.ehx.0000407659.43685.92.

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15

Wilson, Kitchener D., and Joseph C. Wu. "Induced Pluripotent Stem Cells." JAMA 313, no. 16 (2015): 1613. http://dx.doi.org/10.1001/jama.2015.1846.

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16

Ikehara, Susumu. "Pluripotent Hemopoietic Stem Cells in Mice and Humans." Proceedings of the Society for Experimental Biology and Medicine 223, no. 2 (2000): 149–55. http://dx.doi.org/10.1046/j.1525-1373.2000.22320.x.

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Ikehara, Susumu. "Pluripotent Hemopoietic Stem Cells in Mice and Humans." Proceedings of the Society for Experimental Biology and Medicine 223, no. 2 (2008): 149–55. http://dx.doi.org/10.1111/j.1525-1373.2000.22320.x.

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18

Hagenaars, C. E., A. A. M. van der Kraan, E. W. M. Kawilarang-de Haas, J. W. M. Visser, and P. J. Nijweide. "Osteoclast formation from cloned pluripotent hemopoietic stem cells." Bone and Mineral 6, no. 2 (1989): 179–89. http://dx.doi.org/10.1016/0169-6009(89)90049-4.

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Schneider, Gary B., Melanie Relfson, and John Nicolas. "Pluripotent hemopoietic stem cells give rise to osteoclasts." American Journal of Anatomy 177, no. 4 (1986): 505–11. http://dx.doi.org/10.1002/aja.1001770408.

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20

Dupuis, Victoria, and Elisa Oltra. "Methods to produce induced pluripotent stem cell-derived mesenchymal stem cells: Mesenchymal stem cells from induced pluripotent stem cells." World Journal of Stem Cells 13, no. 8 (2021): 1094–111. http://dx.doi.org/10.4252/wjsc.v13.i8.1094.

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21

Delgado-Olguin, P., and F. Recillas-Targa. "Chromatin structure of pluripotent stem cells and induced pluripotent stem cells." Briefings in Functional Genomics 10, no. 1 (2011): 37–49. http://dx.doi.org/10.1093/bfgp/elq038.

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22

Esposito, M. T. "Hematopoietic stem cells meet induced pluripotent stem cells technology." Haematologica 101, no. 9 (2016): 999–1001. http://dx.doi.org/10.3324/haematol.2016.150755.

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23

Geoghegan, Eamon, and Lucy Byrnes. "Mouse induced pluripotent stem cells." International Journal of Developmental Biology 52, no. 8 (2008): 1015–22. http://dx.doi.org/10.1387/ijdb.082640eg.

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24

Lu, Y., JL Mumaw, FD West, and SL Stice. "Livestock Induced Pluripotent Stem Cells." Reproduction in Domestic Animals 47 (July 25, 2012): 72–76. http://dx.doi.org/10.1111/j.1439-0531.2012.02057.x.

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25

Waldron, Denise. "Chimpanzee induced pluripotent stem cells." Nature Reviews Genetics 16, no. 8 (2015): 439. http://dx.doi.org/10.1038/nrg3988.

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26

Li, Shujuan, Lan Zhang, Qi Zhou, Siyuan Jiang, Yi Yang, and Yun Cao. "Characterization of Stem Cells and Immune Cells in Preterm and Term Mother’s Milk." Journal of Human Lactation 35, no. 3 (2019): 528–34. http://dx.doi.org/10.1177/0890334419838986.

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Background: Human milk is known to be rich in cellular components, including stem cells and immune cells. However, the dynamics of these cellular components at different lactation stages, and the differences between milk for preterm and term infants, are poorly understood. Research aim: To identify changes in the cellular components of human milk at different lactation stages, and to explore the associations of these changes with maternal and infant characteristics. Methods: Forty mothers of newborns of different gestational ages were enrolled. Colostrum, transitional, and mature milk samples
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27

Bridge, Sophie. "Induced Pluripotent Stem Cells: An Alternative to Embryonic Stem Cells?" Asian Bioethics Review 5, no. 1 (2013): 25–39. http://dx.doi.org/10.1353/asb.2013.0002.

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28

Kim, Jeong Beom, Holm Zaehres, Marcos J. Araúzo-Bravo, and Hans R. Schöler. "Generation of induced pluripotent stem cells from neural stem cells." Nature Protocols 4, no. 10 (2009): 1464–70. http://dx.doi.org/10.1038/nprot.2009.173.

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29

Guillot, Pascale V. "Induced pluripotent stem (iPS) cells from human fetal stem cells." Best Practice & Research Clinical Obstetrics & Gynaecology 31 (February 2016): 112–20. http://dx.doi.org/10.1016/j.bpobgyn.2015.08.007.

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30

Cha, Jihyun, Sunhoo Park, and Seung Bum Lee. "Induced Pluripotent Stem Cells: Next Generation Stem Cells to Clinical Applications." Hanyang Medical Reviews 35, no. 4 (2015): 190. http://dx.doi.org/10.7599/hmr.2015.35.4.190.

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Spinelli, Valentina, Pascale V. Guillot, and Paolo De Coppi. "Induced pluripotent stem (iPS) cells from human fetal stem cells (hFSCs)." Organogenesis 9, no. 2 (2013): 101–10. http://dx.doi.org/10.4161/org.25197.

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Park, Siyeon, and Gun-Il Im. "Embryonic Stem Cells and Induced Pluripotent Stem Cells for Skeletal Regeneration." Tissue Engineering Part B: Reviews 20, no. 5 (2014): 381–91. http://dx.doi.org/10.1089/ten.teb.2013.0530.

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Sun, Guoqiang, Chelsea Fu, Caroline Shen, and Yanhong Shi. "Histone Deacetylases in Neural Stem Cells and Induced Pluripotent Stem Cells." Journal of Biomedicine and Biotechnology 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/835968.

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Stem cells have provided great hope for the treatment of a variety of human diseases. However, the molecular mechanisms underlying stem cell pluripotency, self-renewal, and differentiation remain to be unveiled. Epigenetic regulators, including histone deacetylases (HDACs), have been shown to coordinate with cell-intrinsic transcription factors and various signaling pathways to regulate stem cell pluripotency, self-renewal, and fate determination. This paper focuses on the role of HDACs in the proliferation and neuronal differentiation of neural stem cells and the application of HDAC inhibitor
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Wang, Yimei, Jinyu Liu, Xiaohua Tan, et al. "Induced Pluripotent Stem Cells from Human Hair Follicle Mesenchymal Stem Cells." Stem Cell Reviews and Reports 9, no. 4 (2012): 451–60. http://dx.doi.org/10.1007/s12015-012-9420-5.

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Cummins, Paul J. "Potential and Induced Pluripotent Stem Cells." Ethics in Biology, Engineering and Medicine 3, no. 4 (2012): 263–74. http://dx.doi.org/10.1615/ethicsbiologyengmed.2013007570.

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Miyamoto, Yoshitaka, Hirofumi Noguchi, Hiroshi Yukawa, et al. "Cryopreservation of Induced Pluripotent Stem Cells." Cell Medicine 3, no. 1-3 (2012): 89–95. http://dx.doi.org/10.3727/215517912x639405.

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Singh, Anubha, Deepak Kumar Singh, and Usha Bhoria. "Induced pluripotent stem cells: An update." International Journal of Blood transfusion and Immunohematology 5 (2015): 6. http://dx.doi.org/10.5348/ijbti-2015-16-ra-2.

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Singh, Anubha, Deepak Kumar Singh, and Usha Bhoria. "Induced pluripotent stem cells in infections." International Journal of Blood transfusion and Immunohematology 5 (2015): 14. http://dx.doi.org/10.5348/ijbti-2015-17-ra-3.

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Calabrese, Edward J. "Induced Pluripotent Stem Cells and Hormesis." Dose-Response 20, no. 1 (2022): 155932582210755. http://dx.doi.org/10.1177/15593258221075504.

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This paper represents the first assessment of agent-induced hormetic dose responses in induced pluripotent stem cells and their derived cells. The hormetic dose responses were induced by a broad range of chemicals, including pharmaceuticals (eg, metformin), dietary supplements/extracts from medicinal plants (eg, curcumin), and endogenous agents (eg, melatonin). The paper assesses the mechanistic foundations of these induced hormetic dose responses, their therapeutic implications and comparison with hormetic responses in multiple adult and embryonic stem cells.
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BEYENE, ROBEL, and JOHN A. BOOCKVAR. "Disease-specific Induced Pluripotent Stem Cells." Neurosurgery 63, no. 6 (2008): N12. http://dx.doi.org/10.1227/01.neu.0000313629.07947.66.

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Okita, Keisuke, Naoki Nagata, and Shinya Yamanaka. "Immunogenicity of Induced Pluripotent Stem Cells." Circulation Research 109, no. 7 (2011): 720–21. http://dx.doi.org/10.1161/res.0b013e318232e187.

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Zeuschner, Dagmar, Karina Mildner, Holm Zaehres, and Hans R. Schöler. "Induced Pluripotent Stem Cells at Nanoscale." Stem Cells and Development 19, no. 5 (2010): 615–20. http://dx.doi.org/10.1089/scd.2009.0159.

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Zhao, Tongbiao, Zhen-Ning Zhang, Zhili Rong, and Yang Xu. "Immunogenicity of induced pluripotent stem cells." Nature 474, no. 7350 (2011): 212–15. http://dx.doi.org/10.1038/nature10135.

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Feng, Chunjing, Yun-Dan Jia, and Xiao-Yang Zhao. "Pluripotency of Induced Pluripotent Stem Cells." Genomics, Proteomics & Bioinformatics 11, no. 5 (2013): 299–303. http://dx.doi.org/10.1016/j.gpb.2013.08.003.

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Sunil, ParamelMohan. "Induced pluripotent stem cells in dentistry." Journal of Pharmacy And Bioallied Sciences 8, no. 5 (2016): 23. http://dx.doi.org/10.4103/0975-7406.191960.

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Ruetz, Tyson, and Keisuke Kaji. "Routes to induced pluripotent stem cells." Current Opinion in Genetics & Development 28 (October 2014): 38–42. http://dx.doi.org/10.1016/j.gde.2014.08.006.

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Park, In-Hyun, Natasha Arora, Hongguang Huo, et al. "Disease-Specific Induced Pluripotent Stem Cells." Cell 134, no. 5 (2008): 877–86. http://dx.doi.org/10.1016/j.cell.2008.07.041.

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Liu, De Wu, Yong Tie Li, De Ming Liu, and Pu Ning. "Culture and Characteristics of Human Induced Pluripotent Stem Cells." Advanced Materials Research 268-270 (July 2011): 835–37. http://dx.doi.org/10.4028/www.scientific.net/amr.268-270.835.

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Human induced pluripotent stem cells is promising for regenerative medicine and tissue engineering. In this chapter, we focus on the culture and characteristics of human induced pluripotent stem cells. The induced pluripotent stem cells were plated on murine embryonic fibroblast feeder cells and expanded in human embryonic stem cells media contained basic fibroblast growth factor. The cells were passaged by collagenase IV digestion method and observed under invert microscope. The expression of alkaline phosphatase was detected by immunocytochemistry. The cultured induced pluripotent stem cells
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Lee, Jung Min. "When CAR Meets Stem Cells." International Journal of Molecular Sciences 20, no. 8 (2019): 1825. http://dx.doi.org/10.3390/ijms20081825.

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The generation of immune cells from human pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells) has been of keen interest to regenerative medicine. Pluripotent stem cell-derived immune cells such as natural killer cells, macrophages, and lymphoid cells, especially T cells, can be used in immune cell therapy to treat incurable cancers. Moreover, since the advent of chimeric antigen receptor (CAR) technology, the success of CAR-T cells in the clinic has galvanized new efforts to harness the power of CAR technology to generate CAR-engineered immune cells from pluripoten
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Amoh, Yasuyuki, Kensei Katsuoka, and Robert M. Hoffman. "The advantages of hair follicle pluripotent stem cells over embryonic stem cells and induced pluripotent stem cells for regenerative medicine." Journal of Dermatological Science 60, no. 3 (2010): 131–37. http://dx.doi.org/10.1016/j.jdermsci.2010.09.007.

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