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Littérature scientifique sur le sujet « Hydantoin derivatives »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 26 juillet 2025

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Articles de revues sur le sujet "Hydantoin derivatives"

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Wadghane, Somnath, Rohit Bhor, Ganesh Shinde, Mahesh Kolhe, and Pooja Rathod. "A Review on the Some Biological Activities of the Hydantoin Derivatives." Journal of Drug Delivery and Therapeutics 13, no. 1 (2023): 171–78. http://dx.doi.org/10.22270/jddt.v13i1.5904.

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Hydantoin derivatives are commonly used anticonvulsants. In general, they are effective for partial-onset seizures and tonic-clonic seizures, but not for absence seizures. Phenytoin is the most important drug in this group, and other drugs, ethotoin, and mephenytoin, are also commonly used to treat epilepsy. Prodrugs such as derivatives have been created. Phenytoin is effective in some cases of trigeminal neuralgia and related neuralgia. Phenytoin is also used to treat arrhythmias. Hydantoins or glycolylureas are heterocyclic organic compounds with the formula CH2C(O)NHC(O)NH. It is a colorles

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Šmit, Biljana, Ivana Radojević, Petar Stanić, Darko Ašanin, Marijana Vasić, and Jelena Katanić-Stanković. "Synthesis of series of different imidazolidine-2,4-dione derivatives and evaluation of their antimicrobial potential." Kragujevac Journal of Science, no. 44 (2022): 57–74. http://dx.doi.org/10.5937/kgjsci2244057s.

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A series of twenty two different imidazolidine-2,4-dione derivatives, divided according to their structure into five groups, including alkyl, alkenyl or aryl 5,5disubstituted hydantoins, spirohydantoins, and fused bicyclic and tricyclic hydantoins, was synthesized and examined for in vitro antimicrobial activity against 15 strains of bacteria and 4 strains of yeast. The antimicrobial activity was evaluated by the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) using the microdilution method. The assayed compounds exerted moderate ant

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López-López, Lluvia Itzel, Denisse de Loera, Ernesto Rivera-Avalos, and Aidé Sáenz-Galindo. "Green Synthesis of Hydantoins and Derivatives." Mini-Reviews in Organic Chemistry 17, no. 2 (2020): 176–84. http://dx.doi.org/10.2174/1570193x16666181206100225.

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The hydantoin moiety is found in several bioactive compounds with important pharmacological properties such as antimicrobial, antifungal, anti-androgens, anticancer and the historical action anticonvulsant. Because of these reasons, the synthesis of these compounds and their derivatives is important to review considering the philosophy of the green chemistry. In this review, we present the actual importance in the green synthesis of hydantoins and their derivatives using green methods, such as microwave and ultrasound irradiation, ionic liquids, solid-phase and solvent-free synthesis. Finally,

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Ganchev, Donyo, Marin Marinov, Stefan Krustev, Milena Zlateva, Nadezhda Atanasova, and Neyko Stoyanov. "PHYTOTOXICOLOGICAL STUDY OF SOME SPIROHYDANTOINS AND THEIR DERIVATIVES TOWARDS PSEUDOCROSSIDIUM REVOLUTUM." Journal scientific and applied research 3, no. 1 (2013): 20–25. http://dx.doi.org/10.46687/jsar.v3i1.58.

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This article presents a novel ecotoxicological investigation of probable deleterious effect of cyclopentanespiro-5-hydantoin, cyclohexanespiro-5-hydantoin, cyclopentanespiro-5-(2,4-dithiohydantoin) and 1-aminocyclopentanecarboxylic acid towards some of the most widespread moss species in the World – Pseudocrossidium revolutum.. Dose-response modeling was carried out by R language for Statistical Computing, drc package.

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Yu, Fang-Lei, Carl H. Schwalbe, and David J. Watkin. "Hydantoin and hydrogen-bonding patterns in hydantoin derivatives." Acta Crystallographica Section C Crystal Structure Communications 60, no. 10 (2004): o714—o717. http://dx.doi.org/10.1107/s0108270104017706.

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Bhadreshkumar. R. Sudani. "The Multifaceted Biological Activities of Hydantoin Derivatives: From Antimicrobial to Anticancer Agents." Bioscan 19, Supplement 2 (2024): 88–92. http://dx.doi.org/10.63001/tbs.2024.v19.i02.s2.pp88-92.

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Hydantoin derivatives, a versatile class of heterocyclic compounds, have garnered significant attention in recent years due to their diverse biological activities. These derivatives exhibit a wide range of pharmacological properties, making them valuable candidates in the development of therapeutic agents. This review highlights the multifaceted biological activities of Hydantoin derivatives, with a focus on their antimicrobial and anticancer properties. The antimicrobial efficacy of these compounds encompasses activity against various bacterial, fungal, and viral pathogens, presenting them as

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Shabnam Babu Shaikh, Rohit Jaysing Bhor, Amol Sopanrao Dighe, and Mahesh Hari Kolhe. "Novel new research strategies of hydantoin derivatives: A review." International Journal of Scholarly Research in Biology and Pharmacy 2, no. 1 (2023): 010–14. http://dx.doi.org/10.56781/ijsrbp.2023.2.1.0011.

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A non-aromatic five membered heterocycle known as hydantoin, imidazolidine-2,4-dione, is regarded as a desirable, preferred scaffold in medicinal chemistry. In addition to phenytoin, Nitrofurantoin, and Enzalutamide, the importance of the hydantoin scaffold in drug discovery has been supported by a number of medications currently in use. Hydantoin has two hydrogen bond acceptors and two hydrogen bond donors among its five possible substituent sites. Because they display a variety of biological and pharmacological activity in therapeutic and agrochemical applications, hydantoin and the hybrids

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Hanessian, Stephen, Rui-Yang Yang, and Jean-Yves Sancéau. "Synthesis of 1-N-hydroxyhydantoin 5-phosphates as potential fungicides." Canadian Journal of Chemistry 75, no. 6 (1997): 712–15. http://dx.doi.org/10.1139/v97-085.

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Two hydantoin analogs were synthesized utilizing an organometallic allylation reaction in aqueous solution as a key step. One of the derivatives showed weak fungicidal activity. Keywords: hydantoin, fungicide, phosphate.

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ASAKAWA, Takanobu, and Somei YARITA. "Noncyanide Silver Plating Solution Using Hydantoin and Hydantoin Derivatives." Journal of the Surface Finishing Society of Japan 50, no. 1 (1999): 68–71. http://dx.doi.org/10.4139/sfj.50.68.

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Trisovic, Nemanja, Gordana Uscumlic, and Slobodan Petrovic. "Hydantoins: Synthesis, properties and anticonvulsant activity." Chemical Industry 63, no. 1 (2009): 17–31. http://dx.doi.org/10.2298/hemind0901017t.

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Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

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Thèses sur le sujet "Hydantoin derivatives"

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Howie, Colin. "The design, synthesis and testing of hydantoin derivatives as inhibitors of pyrimidine biosynthesis." Thesis, University of Glasgow, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278514.

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EVARISTO, Miguel do Rosário. "Biological activity of well defined hydantoin derivatives on efflux pump systems of bacteria and cancer cells." Master's thesis, Instituto de Higiene e Medicina Tropical, 2010. http://hdl.handle.net/10362/5617.

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A multi-resistência a antibióticos e medicamentos usados em quimioterapia é um dos grandes problemas com os quais as instituições de saúde se debatem hoje em dia. A acção provocada por bombas de efluxo é uma das suas causas. Estas bombas têm uma importância fundamental, uma vez que, ao expelirem todo o tipo de tóxicos para o exterior das células, também expelem medicamentos, fazendo com que estes não tenham o efeito desejado dentro delas. As bombas de efluxo são transportadores que se encontram nas membranas de todo o tipo de células. Existem dois grandes tipos de bombas de efluxo: as primári

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Otrebska-Machaj, Ewa. "The search for new inhibitors of bacterial efflux pumps among amine derivates of 5-Arylidenehydantoin." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5010.

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L’objet de ces recherches était de trouver de nouveaux EPIs du système d’efflux AcrAB-TolC dans les groupes de dérivés d’amine de la 5-arylidenehydantoine et de la 5-arylideneimidazolone. Dans la première étape de recherche, 32 nouveaux dérivés ont été obtenus après modification de la structure lead P2.Un screening théorique du risque toxique et la prédiction des propriétés médicamenteuses des composés ont été réalisés en utilisant le programme OSIRIS qui calcule différentes propriétés médicamenteuses pertinentes basées sur la structure planaire de la molécule.Dans l’étape suivante de la reche

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Filippin, Fernanda Branco. "Avaliação da atividade citotóxica e melanogênica do complexo de platina (II) com derivado de hidantoína em melanoma." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-15012014-151634/.

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Considerando o melanoma a forma mais agressivas de câncer de pele e mais resistente aos tratamentos convencionais, o presente estudo teve como objetivo avaliar a atividade de um novo complexo de platina (II) com derivado de hidantoína (CX42) em células de melanoma humano e murino. Foram utilizados também para comparação células da pele (fibroblastos, queratinócitos e melanócitos) e os compostos cisplatina (CIS) e complexo de hidantoína isolado (NN10). Ensaios de viabilidade, ciclo e morte celular foram realizados. Investigou-se também a atividade da enzima tirosinase, principal enzima que regu

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Huang, Jia-Yun, and 黃佳筠. "(I) Synthesis of Thio(seleno)hydantoin-fused tetrahydroisoquinolines and diketopiperazine-fused tetrahydroisoquinolines (II) One-pot Synthesis of Chiral 2-imino thia(selena)zole derivatives and 2-thio(seleno)xoimidazolin-4-ones." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/b2757e.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>107<br>The first part deals with the diastereoselective synthesis of thio(seleno)-hydantoin-fused tetrahydroisoquinolines and diketopiperazine-fused tetrahydro-isoquinolines via the molecular hybridization synthetic strategy. The second part describes the one-pot regioselective synthesis of chiral 2-iminothia(selena)zole derivatives and 2-thio(seleno)xoimidazolin-4-ones through multi-component reactions.

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Livres sur le sujet "Hydantoin derivatives"

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Parker, Philip M. The 2007 Import and Export Market for Hydantoin and Its Derivatives in China. ICON Group International, Inc., 2006.

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Parker, Philip M. The World Market for Hydantoin and Its Derivatives: A 2007 Global Trade Perspective. ICON Group International, Inc., 2006.

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The World Market for Hydantoin and Its Derivatives: A 2004 Global Trade Perspective. Icon Group International, Inc., 2005.

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Parker, Philip M. The 2007 Import and Export Market for Hydantoin and Its Derivatives in United States. ICON Group International, Inc., 2006.

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Chapitres de livres sur le sujet "Hydantoin derivatives"

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Madkour, Loutfy H., Savaş Kaya, Ime Bassey Obot, and Lei Guo. "Hydantoins-Based Corrosion Inhibitors for Mild Steel in Acidic and Alkaline Solutions." In Advances in Chemical and Materials Engineering. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-6341-6.ch011.

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Hydantoins substituents have been studied as corrosion inhibitors for mild steel in HNO3 and NaOH media. The studies involve chemical and electrochemical methods. Weight loss, thermometric and Potentiodynamic polarization (PDP) have been applied. The experimental measurements have been confirmed by quantum chemical calculations and Monte Carlo simulation (MCS). Potentiodynamic polarization studies reveal that the hydantoin derivatives act as mixed type inhibitor. The adsorption obeyed the Temkin adsorption isotherm model. Electronic parameters relevant to their inhibition activity such as EHOM

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Jones, John. "α-Amino acid synthesis." In Amino Acid and Peptide Synthesis. Oxford University Press, 2002. http://dx.doi.org/10.1093/hesc/9780199257386.003.0002.

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This chapter examines proteinogenic α-amino acids that are produced industrially by fermentation methods and chemical synthesis on a vast scale. It highlights the principal application of α-amino acids as food additives and cheap starting materials for laboratory work. It also considers the synthesis of α-amino acids as an active field wherein there is demand for specifically labelled, unnatural, and unusual amino acids. The chapter explores the general methods of synthesis of α-amino acids, including the displacement reactions on α-halo acids, Strecker synthesis, approaches through hydantoins

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Actes de conférences sur le sujet "Hydantoin derivatives"

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Smit, Biljana, Ivana Radojevic, Marijana Djukic, Ljiljana Comic, and Darko Asanin. "Antimicrobial Activity of Various Hydantoin Derivatives ." In 2nd International Electronic Conference on Medicinal Chemistry. MDPI, 2016. http://dx.doi.org/10.3390/ecmc-2-a032.

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Lazić, Anita, Ivana Đorđević, Kristina Gak Simić та ін. "Correlation of structure and potential pharmacological activity of spirohidantoins derived from α-Tetralone". У 37th International Congress on Process Industry. SMEITS, 2024. http://dx.doi.org/10.24094/ptk.024.279.

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Hydantoin is a nonaromatic five-membered heterocycle, which is considered a valuable, privileged scaffold in medicinal chemistry. The importance of the hydantoin scaffold in drug dis-covery has been reinforced by several medicines in clinical use, such as anticonvulsants (phenyto-in), antibiotics (nitrofurantoin), anticancer drugs (enzalutamide) and keratolytics (allantoin). To design new potentially pharmacologically active compounds, six spirohydantoin derivatives were synthetized and fully characterized by determination of the melting points, elemental analysis, FT-IR, 1H and 13C NMR spectr

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Haq, Kautsar Ul, Septi Rosiana Dewi, Sherly Dwi Cicilianingrum, et al. "Synthesis of 5-benzylidene-hydantoin and 5-benzylidene-creatinine derivatives under mixed catalyst systems of urea-p-toluenesulfonic acid (Urea-PTSA) and guanidine hydrochloride-triethylamine (GnHCl-TEA)." In THE 14TH JOINT CONFERENCE ON CHEMISTRY 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0005378.

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