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Littérature scientifique sur le sujet « Hypoglycemic properties »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "Hypoglycemic properties"

Pashkova, E. Iu. "The new therapeutic modalities for the treatment of type 2 diabetes mellitus: insulin detemir added to liraglutide." Problems of Endocrinology 59, no. 4 (2013): 50–55. http://dx.doi.org/10.14341/probl201359450-55.

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he literature data on the effectiveness and safety of the essentially new scheme of hypoglycemic therapy of type 2 diabetes mellitus are presented, The large-scale 52 week study has demonstrated that the addition of insulin detemir to the preceding treatment with liraglutide makes it possible to reach and maintain glycated hemoglobin percentage at the desired level of 7% in 43% of the patients. The risk of development of hypoglycemia was estimated at 0.286 episodes per patient per year in the absence of body weight increment. The combination of these two medications was found to produce pronou

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Petunina, N. A., N. S. Martirosian, E. V. Goncharova, et al. "The place of gliclazide MB in modern treatment strategies for patients with type 2 diabetes mellitus." Diabetes mellitus 27, no. 4 (2024): 368–75. http://dx.doi.org/10.14341/dm13184.

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Sulfonylurea (SU) are an effective class of oral hypoglycemic drugs that have been used in clinical practice for more than 70 years. Despite the common mechanism of action, members of the class have significant intraclass differences in hypoglycemic activity, safety, and the presence of extrapancreatic effects. This review examines the features of gliclazide modified release (MR), its differences from other representatives of the SU and its place in modern recommendations for the treatment of type 2 diabetes mellitus. Gliclazide MR belongs to the modern 2nd generation SU with high hypoglycemic

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Koussoube, Abdelaziz, Filkpièrè Léonard DA, Maya Doukoure, et al. "Assessment of antioxidant activity and hypoglycemic and anti-hyperglycemic effects of the hydroethanolic extract of the trunk bark of Lannea acida A. Rich. (Anacardiaceae) in male NMRI mice." International Journal of Research in Pharmaceutical Sciences 16, no. 2 (2025): 61–69. https://doi.org/10.26452/ijrps.v16i2.4755.

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Lannea acida A. Rich (Anacardiaceae) is a plant widely used in African traditional medicine to treat various ailments, including diabetes and infertility. This study aimed to evaluate the antioxidant, hypoglycemic, and anti-hyperglycemic activities of the hydroethanolic extract from its trunk bark in male NMRI mice. Antioxidant activity was assessed using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ferric reducing antioxidant power (FRAP) assays. Hypoglycemic effects were tested in fasting normoglycemic mice divided into five groups (n=5). The anti-hyperglycemic activity was evaluated via an oral

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Borisov, Sergey A., Olga A. Luzina, Mikhail V. Khvostov, Tatiana G. Tolstikova, and Nariman F. Salakhutdinov. "Synthesis and Pharmacological Evaluation of (+)-Usnic Acid Derivatives as Hypoglycemic Agents." Molbank 2022, no. 4 (2022): M1459. http://dx.doi.org/10.3390/m1459.

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Usnic acid is produced by lichens and exhibits different biological properties, including hypoglycemic ones. However, this effect becomes noticeable only at relatively high doses, something that may lead to some adverse effects. The chemical modification of the molecule is able to enhance its safety profile and its hypoglycemic properties. We synthesized six enamine derivatives of (+)-usnic acid, and two of them are novel. All compounds were evaluated for the hypoglycemic effect after oral introduction in mice with alloxan-induced diabetes mellitus at a dose of 50 mg/kg. The derivative contain

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Hu, Fangdi, Xiaodong Li, Lianggong Zhao, Shilan Feng, and Chunming Wang. "Antidiabetic properties of purified polysaccharide fromHedysarum polybotrys." Canadian Journal of Physiology and Pharmacology 88, no. 1 (2010): 64–72. http://dx.doi.org/10.1139/y09-098.

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Hedysarum polybotrys polysaccharide (HPS) is the principal active fraction responsible for the antidiabetic properties of this species. The aim of this study was to determine the antidiabetic properties of 4 purified fractions of different molecular weight range HPSs (HPS1, HPS2, HPS3, HPS4). HPS3 was selected for examination of its hypoglycemic mechanism because of its significant hypoglycemic effect in alloxan-induced diabetic mice. The changes in blood glucose levels and oral glucose tolerance tests (OGTT) showed that hypoglycemia was more pronounced in HPS3-treated groups than in the diabe

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Tan, Seok-Tyug, and Seok-Shin Tan. "A review on the hypoglycemic properties of selected non-leafy vegetables in Malaysia." Nutrition & Food Science 49, no. 6 (2019): 1113–25. http://dx.doi.org/10.1108/nfs-10-2018-0280.

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Purpose Non-communicable diseases such as type 2 diabetes, hypertension, cancers and cardiovascular diseases have become a major health concern globally. As literature claims that frequent consumption of fruits and vegetables can delay the onset of type 2 diabetes and its complications, this paper aims to evaluate the potential hypoglycemic properties in five types of non-leafy vegetables (pumpkin, sweet potato, bitter gourd, onion and lady’s finger), which are commonly available in Malaysia. Design/methodology/approach Articles were identified through several main search engines, including Pu

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Iranmanesh, Ali, German Lizarralde та Johannes D. Veldhuis. "Coordinate activation of the corticotropic axis by insulin-induced hypoglycemia: simultaneous estimates of β-endorphin, adrenocorticotropin and cortisol secretion and disappearance in normal men". Acta Endocrinologica 128, № 6 (1993): 521–28. http://dx.doi.org/10.1530/acta.0.1280521.

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In the present study, we investigated the coordinate kinetic response of the corticotropic axis to the acute metabolic stress of hypoglycemia by applying deconvolution analysis to adrenocorticotropin (ACTH), β-endorphin and cortisol concentration-time series generated in seven normal men after intravenous administration of insulin. Hypoglycemic stress resulted in a 22-fold increase in the mean plasma concentration of ACTH to a maximum of 77±15 pmol/l, in conjunction with a 7.5-fold increase in the mean plasma β-endorphin concentration, the maximal value of which was 96±11 pmol/l. Plasma cortis

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Zhu, Jiangxiong, Hui Zhou, Junyao Zhang, et al. "Valorization of Polysaccharides Obtained from Dark Tea: Preparation, Physicochemical, Antioxidant, and Hypoglycemic Properties." Foods 10, no. 10 (2021): 2276. http://dx.doi.org/10.3390/foods10102276.

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The structure and hypoglycemic activity of tea polysaccharides has been extensively studied, while there are few reports on the characterization and hypoglycemic activity of dark tea polysaccharides. The crude dark tea polysaccharide (CDTPS) was optimally extracted from Fuzhuan dark tea. Six polysaccharide fractions (namely DTPS-1, DTPS-2, DTPS-3, DTPS-4, DTPS-5, and DTPS-6) were isolated from CDTPS, and their physicochemical, structural, and biological properties were compared and analyzed. The results revealed that the compositions, structural characteristics, and biological properties of th

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Eremina, Natalia V., Aliy K. Zhanataev, Artem A. Lisitsyn, and Andrey D. Durnev. "Genotoxic properties of hypoglycemic drugs (systematic review)." Ecological genetics 19, no. 3 (2021): 219–40. http://dx.doi.org/10.17816/ecogen70691.

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According to the literature genotoxic properties of about a half of hypoglycemic drugs have not been investigated in accordance with the recommended methodology, and studies of the mutagen-modifying activity of antidiabetic drugs are sporadic. Based on the available published data, it is impossible to conclude about either presence or absence of genotoxic / antigenotoxic potential of antidiabetic drugs. There is evidence of the antimutagenic activity of metformin; in relation to other drugs, studies of mutagen-modifying activity have not been carried out or are represented only by a few articl

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Dasgupta, Tumpa, Amlan Ganguly, Muhammad Asaduzzaman, and Nazmul Qais. "Evaluation of Anti-microbial, Hypoglycemic and Anti-diarrheal activities of Setaria italica Seeds." Dhaka University Journal of Pharmaceutical Sciences 15, no. 1 (2016): 31–35. http://dx.doi.org/10.3329/dujps.v15i1.29190.

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The ethanolic crude extract of Setaria italica seeds (Poaceae) was investigated for its possible anti-microbial, hypoglycemic and anti-diarrheal activities. Anti-microbial activity was evaluated by disc diffusion method while the hypoglycemic and anti-diarrheal properties were determined by oral glucose tolerance test and castor oil induced diarrheal method, respectively in Albino mice. The ethanolic extract and its different fractions of S. italica have shown good antimicrobial activity against gram negative bacteria having zone of inhibition 9-13 mm (ciprofloxacin: 40- 41 mm). In evaluation

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Thèses sur le sujet "Hypoglycemic properties"

Walmsley, Ryan Steven. "An investigation into the antidiabetic and catalytic properties of oxovanadium(IV) complexes." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1004978.

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In part 1 of this thesis, the antidiabetic activity of a series of novel oxovanadium(IV) complexes was investigated. A range of bidentate N,O-donor ligands, which partially mimic naturally occurring bioligands, were prepared and reacted with the vanadyl ion to form the corresponding bis-coordinated complexes. Initially, 2-(2ˊ-hydroxyphenyl)-1R-imidazoline (where R = H, ethyl and ethanol) ligands were prepared. The aqueous pH-metric chemical speciation was investigated using glass electrode potentiometry which allowed for the determination of protonation and stability constants of the ligands a

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Malapermal, Veshara. "In vitro antidiabetic and antimicrobial properties of Ocimum species (Ocimum basilicum and Ocimum sanctum) (L.)." Thesis, 2016. http://hdl.handle.net/10321/1534.

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Submitted in fulfillment of the requirements of the degree of Master in Technology, Department of Biomedical Technology and Clinical Technology, Durban University of Technology, Durban, South Africa, 2016.<br>Introduction In Africa, use of phytotherapy for treatment of diabetes mellitus is a common form of practice. Considering the increasing burden of non-communicable diseases in South Africa efforts are directed at simple, cost effective, non-hazardous and efficient methods to treat cancer, cardiovascular diseases and diabetes. The role of phytonanotherapy is an attractive proposition for a

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Chapitres de livres sur le sujet "Hypoglycemic properties"

Yilmaz, Mustafa Abdullah, and Oguz Cakir. "Salvia (Sage) Species, a Game-Changer Bioactive Plant: Focus on Antioxidant Properties." In Natural Antioxidants and in Vitro Antioxidant Assays. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359333.4.

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The demand for natural, health-oriented food additives and components has increased, with plant-based foods rich in phytochemicals like phenolic compounds being beneficial for human health. Salvia species, the largest plant family in the Lamiaceae, contain over nine hundred species, including sage, which has numerous beneficial uses and biological properties. Sage extracts have shown antioxidant, hypoglycemic, hypolipidemic, antitumor, anticholinesterase, antimicrobial, and liver-protective properties. S. officinalis L. has been suggested to have an anti-radical effect against uranium toxicity

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Mezouara, Mounia, Karima Hbyaj, Abdelaati Soufiani, et al. "Potential of Functional Foods in Diabetes Management." In Advancements in Climate and Smart Environment Technology. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-3807-0.ch008.

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This synthesis delves into the potential of natural foods, particularly coriander, fig, and green tea, in the management of diabetes. These foods are abundant in bioactive compounds such as polyphenols and flavonoids, which possess antioxidant, anti-inflammatory, and hypoglycemic properties. Research indicates that they play a vital role in regulating blood glucose levels, enhancing insulin sensitivity, and mitigating complications associated with diabetes. For instance, coriander has been shown to exert hypoglycemic effects in animal models of diabetes, while fig extracts demonstrate the abil

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Faris, Mo'ez Al-Islam Ezzat, and Amita Attlee. "Lentils (Lens culinaris, L.)." In Advances in Environmental Engineering and Green Technologies. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-0591-4.ch003.

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Lentils have been part of human diet from ancient times. This chapter focuses on the nutritional composition, presence of bioactive substances, antioxidants and health rendering properties of lentils. Recent definitions have considered lentils as a prophylactic and therapeutic functional food due to its considerable content of essential macronutrients, namely functional proteins and carbohydrates, and essential micronutrients, as well as bioactive phytochemicals such as phytates and polyphenols. Indeed, the presence of an impressive arsenal of secondary metabolites, minerals and bioactive cons

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Faris, Mo'ez Al-Islam Ezzat, and Amita Attlee. "Lentils (Lens culinaris, L.)." In Food Science and Nutrition. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-5207-9.ch016.

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Srivastava, Akanksha, Zoomi Singh, Vandana Verma, and Tashi Choedon. "Potential Health Benefits of Fenugreek With Multiple Pharmacological Properties." In Ethnopharmacological Investigation of Indian Spices. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-2524-1.ch011.

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Fenugreek is one of the familiar spices found in human food and has been used extensively for curing numerous disorders. It provides natural food fibers and other nutrients required in the human body. It is used in functional foods, traditional foods, and nutraceuticals as well as in physiological uses such as antidiabetic agent, antibacterial, hypocholesterolemic, hypoglycemic, antioxidant, enzymatic pathway, and modifier gastric stimulant. It has a valuable influence on digestion and also has the capability to modify food texture. In modern food technology, it is used as a food stabilizer, a

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Srivastava, Akanksha, Zoomi Singh, Vandana Verma, and Tashi Choedon. "Potential Health Benefits of Fenugreek With Multiple Pharmacological Properties." In Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-3546-5.ch034.

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Bhutia, Dhamchoe Dolma, Sajesh Chettri, Sujata Jena, Prashant Pandharinath Said, Shiva Bakshi, and Rohit H.K. "NON-STARCH POLYSACCHARIDES: OVERVIEW, CLASSIFICATION, METHODS FOR ESTIMATION OF NON-STARCH POLYSACCHARIDES AND THEIR PROPERTIES." In Futuristic Trends in Agriculture Engineering & Food Sciences Volume 3 Book 15. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bcag15p4ch2.

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Monosaccharide macromolecules joined by glycosidic linkages are known as polysaccharides. Non-glucan polysaccharides of the plant cell wall make up the majority of non-starch polysaccharides (NSP). They are a diverse category of polysaccharides that vary in size, structure, and water solubility. They are also referred to as hydrocolloids and disperse in water to create viscous dispersants or gels. These gels or dispersants alter colon absorption of nutrients and postprandial blood sugar levels by forming networks or films or by becoming viscouser. NSPs also have a variety of biological functio

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Nelli, Giribabu, Naguib Salleh, and Gowri Gopa Kumar. "Anti-Diabetic Phytochemicals and Their Mode of Action." In Pharmacological Benefits of Natural Agents. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-6737-4.ch009.

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The number of people diagnosed with diabetes mellitus (DM) has risen considerably in recent decades. Diabetes type 1 and 2 are the most frequent types. Type 2 diabetes accounts for 90% of all DM cases globally, making it a 21st-century epidemic. Meanwhile, the side effects and resistance development of routinely used synthetic oral hypoglycemic medications have side effects. It's a need for a safe and less costly substitute. This chapter looks at the anti-diabetic properties of several bioactive compounds derived from plants, such as boldine, bergenin, abietic acid, and myristic acid. This cha

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Saxena, Shweta, Sweta Prakash, and Sadhna Panday. "Crop Improvement Technology With Lawsonia inermis." In Green Chemistry for the Development of Eco-Friendly Products. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-9851-1.ch010.

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Lawsonia inermis L. (family Lythraceae), often known as henna, is a dye-producing plant cultivated in various parts of the world for cosmetic purposes. Since time immemorial, leaf powder made from this little tree has been used to beautify skin, hair, fingernails, leather, silk, and wool. The plant's leaf, which contains an active dye (red orange pigment), lawsone, is widely employed in cosmetic and pharmaceutical industries (2-hydroxy-1,4 naphthoquinone). Lawsone, an essential secondary metabolite, accumulates in the plant's aerial parts, with the highest concentration of 1.0–1.4% in the youn

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Singh, Nidhi, Veer Singh, and Mohan Prasad Singh. "In silico Interactions of the Biomolecules of Edible Mushrooms Against Lifestyle Diseases." In Mushrooms: A Wealth of Nutraceuticals and An Agent of Bioremediation. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815080568123010009.

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Mushrooms are fungi that are consumed all over the world and contain bioactive nutritive components with nutritional and therapeutic qualities. Protein, minerals, vitamins and antioxidants are all found in edible mushrooms. Selenium, vitamin C, and choline are antioxidants that help the human body remove free radicals. Antimicrobial, antiviral, anticancer, anti-allergic, immunomodulation, anti-inflam.matory, anti-atherogenic, hypoglycemic, hepatoprotective, and antioxidant properties of mushrooms. Primary and secondary metabolites can be found in mushrooms. The primary metabolites are energy-p

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Actes de conférences sur le sujet "Hypoglycemic properties"

Robalo, M. Paula, Catarina Henriques, Ana Lopes, and M. Fátima Piedade. "Synthesis of new curcuminoid derivatives with potential antioxidant and hypoglycemic properties." In 6th International Electronic Conference on Medicinal Chemistry. MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07482.

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Nedeljković, Nikola V., Vladimir D. Dobričić, Marina Ž. Mijajlović, et al. "„IN SILICO“ PREDICTION OF PHARMACOKINETIC PROPERTIES AND DRUGLIKENESS OF NOVEL THIOUREA DERIVATIVES OF NAPROXEN." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.371n.

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Masking the carboxyl group of naproxen with other functional groups may be a promising strategy to decrease its gastrointestinal toxicity. Thiourea moiety has been described as an important pharmacophore in a variety of pharmacologically active compounds, including anti-inflammatory, antiviral, anticancer, hypoglycemic and antimicrobial agents. Our research group has previously designed twenty novel thiourea derivatives of naproxen, containing amino acids (glycine, L-alanine, β-alanine, L-valine and L-phenylalanine – compounds 1,2,3,4 and 5, respectively), their methyl (6–10) and ethyl esters

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Abulqasim, Jumana. "18 Fear of hypoglycemia in parents of children with type 1 diabetes: psychometric properties of the Arabic version of the hypoglycemia fear survey for parents of young children." In The 7th ASPED-ISPAD Diabetes Academy. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/bmjpo-2024-asped.18.

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