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Articles de revues sur le sujet « IFITM-2 »

Auteur : Grafiati

Publié le 10 mars 2023

Mis à jour le 19 juillet 2025

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1

Yu, Jingyou, and Shan-Lu Liu. "The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage." Viruses 10, no. 8 (2018): 413. http://dx.doi.org/10.3390/v10080413.

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Interferon inducible transmembrane proteins (IFITMs) are one of several IFN-stimulated genes (ISGs) that restrict entry of enveloped viruses, including flaviviruses, filoviruses and retroviruses. It has been recently reported that in U87 glioblastoma cells IFITM proteins inhibit HIV-1 entry in a co-receptor-dependent manner, that is, IFITM1 is more inhibitory on CCR5 tropic HIV-1 whereas IFITM2/3 confers a greater suppression of CXCR4 counterparts. However, how entry of HIV-1 with distinct co-receptor usage is modulated by different IFITM orthologs in physiologically relevant CD4+ T cells and

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Franz, Sergej, Fabian Pott, Thomas Zillinger, et al. "Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction." Life Science Alliance 4, no. 7 (2021): e202000909. http://dx.doi.org/10.26508/lsa.202000909.

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Interferon-induced transmembrane (IFITM) proteins restrict membrane fusion and virion internalization of several enveloped viruses. The role of IFITM proteins during alphaviral infection of human cells and viral counteraction strategies are insufficiently understood. Here, we characterized the impact of human IFITMs on the entry and spread of chikungunya virus and Mayaro virus and provide first evidence for a CHIKV-mediated antagonism of IFITMs. IFITM1, 2, and 3 restricted infection at the level of alphavirus glycoprotein-mediated entry, both in the context of direct infection and cell-to-cell

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Minakshi, Rinki. "Interferon-Induced Transmembrane Protein: A Moonlighting Protein Against SARS-CoV-2 Infection or in Support of Invasive Ductal Breast Carcinoma?" Asian Pacific Journal of Cancer Care 5, S1 (2020): 241–42. http://dx.doi.org/10.31557/apjcc.2020.5.s1.241-242.

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The interferon-induced transmembrane proteins (IFITMs), widely acting against invading viruses are ubiquitously expressed on the cellular membranes, were previously known for their prominent role in tumorigenesis. Studies productively showed that the entry restriction on SARS-CoV spike glycoprotein agreeably involved the action of frontier IFITM1, 2 and 3. On the contrary, overexpression of IFITM3 has been reported in Invasive ductal breast carcinoma (IDC) tissue specimens where lentivirus-delivered shRNA resulted in targeted silencing of IFITM3 mRNA expression. Despite acting protective again

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Mak, Nelly S. C., Jingyan Liu, Dan Zhang, et al. "Alternative splicing expands the antiviral IFITM repertoire in Chinese rufous horseshoe bats." PLOS Pathogens 20, no. 12 (2024): e1012763. https://doi.org/10.1371/journal.ppat.1012763.

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Species-specific interferon responses are shaped by the virus-host arms race. The human interferon-induced transmembrane protein (IFITM) family consists of three antiviral IFITM genes that arose by gene duplication. These genes restrict virus entry and are key players in antiviral interferon responses. The unique IFITM repertoires in different species influence their resistance to viral infections, but the role of IFITMs in shaping the enhanced antiviral immunity of reservoir bat species is unclear. Here, we identified an IFITM gene in Chinese rufous horseshoe bat, a natural host of severe acu

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Dimech, Christina, and Bhushan Nagar. "Towards a structural characterization of the IFIT antiviral complex." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C246. http://dx.doi.org/10.1107/s2053273314097538.

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Our first line of defense against viral pathogens is the innate immune system. Interferon-induced proteins with tetratricopeptide repeats (IFITs) are innate immune effector molecules that are thought to confer antiviral defense through the formation of the IFIT `Interactome', a multiprotein complex made up of IFIT1, IFIT2, IFIT3 and several other host factors1. Through IFIT1, this complex has the ability to distinguish self from non-self nucleic acids such as virus-derived RNA bearing 5´-triphosphate or viral mRNA lacking 2´-O methylation on the first two nucleotides1,2. We have limited inform

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Hickford, D., A. Pask, G. Shaw, and M. B. Renfree. "264. Primordial germ cell specification in a marsupial, the tammar wallaby." Reproduction, Fertility and Development 20, no. 9 (2008): 64. http://dx.doi.org/10.1071/srb08abs264.

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Primordial germ cells (PGCs) are the precursors of the gametes. In the mouse, PGCs are specified within the proximal epiblast in response to signals from the extraembryonic membranes during early gastrulation. Epiblast cells competent to form PGCs express Ifitm3. A subset of these cells then express Blimp1, a marker of PGC precursors. Once lineage-restricted, PGCs express Stella. Germ cells entering the gonads express VASA protein, which is a component of the germ plasm in animals in which germ cells are specified by the inheritance of maternal determinatives. Almost all of the research on mam

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Confort, Marie-Pierre, Maëva Duboeuf, Adrien Thiesson, et al. "IFITMs from Naturally Infected Animal Species Exhibit Distinct Restriction Capacities against Toscana and Rift Valley Fever Viruses." Viruses 15, no. 2 (2023): 306. http://dx.doi.org/10.3390/v15020306.

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Rift Valley Fever virus (RVFV) and Toscana virus (TOSV) are two pathogenic arthropod-borne viruses responsible for zoonotic infections in both humans and animals; as such, they represent a growing threat to public and veterinary health. Interferon-induced transmembrane (IFITM) proteins are broad inhibitors of a large panel of viruses belonging to various families and genera. However, little is known on the interplay between RVFV, TOSV, and the IFITM proteins derived from their naturally infected host species. In this study, we investigated the ability of human, bovine, and camel IFITMs to rest

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Campbell, Robert A., Jesse W. Rowley, Andrew S. Weyrich, and Matthew T. Rondina. "Surface Ifitms on Megakaryocytes and Platelets Regulate Fibrinogen Endocytosis Under Inflammatory Conditions." Blood 126, no. 23 (2015): 1034. http://dx.doi.org/10.1182/blood.v126.23.1034.1034.

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Abstract Background IFITM proteins (IFITM-1, -2, and -3) mediate cellular resistance to influenza, dengue, and other viruses. IFITM expression on human platelets has not been previously recognized. Our laboratory recently demonstrated that IFITMs are robustly expressed by human platelets and megakaryocytes after stimulation by pathogens and inflammatory mediators and restrict viral infection. IFITMs, which are interferon inducible, also mediate clathrin localization and associated protein endocytosis. Nevertheless, whether IFITMs regulate protein endocytosis by platelets and megakaryocytes rem

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Das, Tandrila, and Howard C. Hang. "Discovery and Characterization of IFITM S-Palmitoylation." Viruses 15, no. 12 (2023): 2329. http://dx.doi.org/10.3390/v15122329.

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Interferon-induced transmembrane proteins (IFITM1, 2 and 3) are important host antiviral defense factors. They are active against viruses like the influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV), Zika virus (ZIKV) and severe acute respiratory syndrome coronavirus (SARS-CoV). In this review, we focus on IFITM3 S-palmitoylation, a reversible lipid modification, and describe its role in modulating IFITM3 antiviral activity. Our laboratory discovered S-palmitoylation of IFITMs using chemical proteomics and demonstrated the importance of highly conserved fatty acid-modified Cys res

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Smith, S. E., M. S. Gibson, R. S. Wash, et al. "Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and LyssavirusesIn Vitro." Journal of Virology 87, no. 23 (2013): 12957–66. http://dx.doi.org/10.1128/jvi.01443-13.

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Interferon-inducible transmembrane protein 3 (IFITM3) is an effector protein of the innate immune system. It confers potent, cell-intrinsic resistance to infection by diverse enveloped viruses bothin vitroandin vivo, including influenza viruses, West Nile virus, and dengue virus. IFITM3 prevents cytosolic entry of these viruses by blocking complete virus envelope fusion with cell endosome membranes. Although the IFITM locus, which includesIFITM1, -2, -3, and -5, is present in mammalian species, this locus has not been unambiguously identified or functionally characterized in avian species. Her

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Mudhasani, R., J. P. Tran, C. Retterer, et al. "IFITM-2 and IFITM-3 but Not IFITM-1 Restrict Rift Valley Fever Virus." Journal of Virology 87, no. 15 (2013): 8451–64. http://dx.doi.org/10.1128/jvi.03382-12.

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Kordbacheh, Ramina, Madelyn Ashley, William D. Cutts, et al. "Common Chemical Plasticizer Di(2-Ethhylhexyl) Phthalate Exposure Exacerbates Coxsackievirus B3 Infection." Viruses 16, no. 12 (2024): 1821. http://dx.doi.org/10.3390/v16121821.

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Di(2-ethhylhexyl) phthalate (DEHP) is a common plastic rubberizer. DEHP leaches from plastic matrices and is under increasing scrutiny as numerous studies have linked it to negative human health manifestations. Coxsackievirus B3 (CVB) is a human pathogen that typically causes subclinical infections but can sometimes cause severe diseases such as pancreatitis, myocarditis, and meningoencephalitis. Though CVB infections are common, severe illness is relatively rare, and it is unclear what factors mediate disease severity. In this study, we sought to determine the effects that DEHP has on CVB inf

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Kumar, Parimal, Trevor R. Sweeney, Maxim A. Skabkin, Olga V. Skabkina, Christopher U. T. Hellen, and Tatyana V. Pestova. "Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5′-terminal regions of cap0-, cap1- and 5′ppp- mRNAs." Nucleic Acids Research 42, no. 5 (2013): 3228–45. http://dx.doi.org/10.1093/nar/gkt1321.

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AbstractRibosomal recruitment of cellular mRNAs depends on binding of eIF4F to the mRNA’s 5′-terminal ‘cap’. The minimal ‘cap0’ consists of N7-methylguanosine linked to the first nucleotide via a 5′-5′ triphosphate (ppp) bridge. Cap0 is further modified by 2′-O-methylation of the next two riboses, yielding ‘cap1’ (m7GpppNmN) and ‘cap2’ (m7GpppNmNm). However, some viral RNAs lack 2′-O-methylation, whereas others contain only ppp- at their 5′-end. Interferon-induced proteins with tetratricopeptide repeats (IFITs) are highly expressed effectors of innate immunity that inhibit viral replication by

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Makled, Amal F., Sahar A. M. Ali, S. S. Eldahdouh, et al. "Angiotensin-Converting Enzyme-2 (ACE-2) with Interferon-Induced Transmembrane Protein-3 (IFITM-3) Genetic Variants and Interleukin-6 as Severity and Risk Predictors among COVID-19 Egyptian Population." International Journal of Microbiology 2023 (December 21, 2023): 1–12. http://dx.doi.org/10.1155/2023/6384208.

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Introduction. The host genetic background is a crucial factor that underlies the interindividual variability of COVID-19 fatality and outcomes. Angiotensin-converting enzyme-2 (ACE-2) and interferon-induced transmembrane protein-3 (IFITM-3) have a key role in viral cell entrance and priming. The evoked immune response will also provide a predictive prognosis for COVID-19 infection. This study aimed to explore the association between ACE-2 and IFITM-3 genotypes and their corresponding allele frequencies with disease severity indices in the Egyptian COVID-19 population. The serum level of interl

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Wang, Jingjing, Yuhang Luo, Harshita Katiyar, Chen Liang, and Qian Liu. "The Antiviral Activity of Interferon-Induced Transmembrane Proteins and Virus Evasion Strategies." Viruses 16, no. 5 (2024): 734. http://dx.doi.org/10.3390/v16050734.

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Interferons (IFNs) are antiviral cytokines that defend against viral infections by inducing the expression of interferon-stimulated genes (ISGs). Interferon-inducible transmembrane proteins (IFITMs) 1, 2, and 3 are crucial ISG products and members of the CD225 protein family. Compelling evidence shows that IFITMs restrict the infection of many unrelated viruses by inhibiting the virus–cell membrane fusion at the virus entry step via the modulation of lipid composition and membrane properties. Meanwhile, viruses can evade IFITMs’ restrictions by either directly interacting with IFITMs via viral

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Franco, Justin H., Saurabh Chattopadhyay, and Zhixing K. Pan. "How Different Pathologies Are Affected by IFIT Expression." Viruses 15, no. 2 (2023): 342. http://dx.doi.org/10.3390/v15020342.

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The type-I interferon (IFN) system represents the first line of defense against viral pathogens. Recognition of the virus initiates complex signaling pathways that result in the transcriptional induction of IFNs, which are then secreted. Secreted IFNs stimulate nearby cells and result in the production of numerous proinflammatory cytokines and antiviral factors. Of particular note, IFN-induced tetratricopeptide repeat (IFIT) proteins have been thoroughly studied because of their antiviral activity against different viral pathogens. Although classically studied as an antiviral protein, IFIT exp

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Compton, Alex A., Tiansheng Li, Guoli Shi, et al. "The extracellular tail of IFITM3 promotes SARS-CoV-2 entry into cells and is diversifying in primates." Journal of Immunology 210, no. 1_Supplement (2023): 71.32. http://dx.doi.org/10.4049/jimmunol.210.supp.71.32.

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Abstract The interferon-induced transmembrane (IFITM) proteins confer cells with resistance to diverse virus infections by altering membrane biomechanics and disfavoring virus-cell membrane fusion. Human IFITM3 strongly restricts SARS-CoV and MERS Spike-mediated infections in endosomes. However, work from our labs demonstrated that IFITM3 has opposing effects on SARS-CoV-2 (SCV2) infection: IFITM3 in endosomes restricts SCV2 infection, but IFITM3 at the cell surface enhances SCV2 infection. In the present study, we investigated the determinants governing the enhancement of SCV2 infection by hu

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Pawar, Puja, Jyotsna Gokavi, Shilpa Wakhare, et al. "MiR-155 Negatively Regulates Anti-Viral Innate Responses among HIV-Infected Progressors." Viruses 15, no. 11 (2023): 2206. http://dx.doi.org/10.3390/v15112206.

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HIV infection impairs host immunity, leading to progressive disease. An anti-retroviral treatment efficiently controls viremia but cannot completely restore the immune dysfunction in HIV-infected individuals. Both host and viral factors determine the rate of disease progression. Among the host factors, innate immunity plays a critical role; however, the mechanism(s) associated with dysfunctional innate responses are poorly understood among HIV disease progressors, which was investigated here. The gene expression profiles of TLRs and innate cytokines in HIV-infected (LTNPs and progressors) and

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Steyn, Angela, Sarah Keep, Erica Bickerton, and Mark Fife. "The Characterization of chIFITMs in Avian Coronavirus Infection In Vivo, Ex Vivo and In Vitro." Genes 11, no. 8 (2020): 918. http://dx.doi.org/10.3390/genes11080918.

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The coronaviruses are a large family of enveloped RNA viruses that commonly cause gastrointestinal or respiratory illnesses in the infected host. Avian coronavirus infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of chickens that can affect the kidneys and reproductive systems resulting in bird mortality and decreased reproductivity. The interferon-inducible transmembrane (IFITM) proteins are activated in response to viral infections and represent a class of cellular restriction factors that restrict the replication of many viral pathogens. Here, we characterize th

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Yánez, Diana C., Hemant Sahni, Susan Ross, et al. "IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation." European Journal of Immunology 49, no. 1 (2018): 66–78. http://dx.doi.org/10.1002/eji.201847692.

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Zhu, Zhengyu, Xiaoyun Yang, Chaoqun Huang, and Lin Liu. "The Interferon-Induced Protein with Tetratricopeptide Repeats Repress Influenza Virus Infection by Inhibiting Viral RNA Synthesis." Viruses 15, no. 7 (2023): 1412. http://dx.doi.org/10.3390/v15071412.

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Influenza A virus (IAV) is an eight-segment negative-sense RNA virus and is subjected to gene recombination between strains to form novel strains, which may lead to influenza pandemics. Seasonal influenza occurs annually and causes great losses in public healthcare. In this study, we examined the role of interferon-induced protein with tetratricopeptide repeats 1 and 2 (IFIT1 and IFIT2) in influenza virus infection. Knockdown of IFIT1 or IFIT2 using a lentiviral shRNA increased viral nucleoprotein (NP) and nonstructural protein 1 (NS1) protein levels, as well as progeny virus production in A/P

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Vishnubalaji, Radhakrishnan, Hibah Shaath, and Nehad M. Alajez. "Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response." Genes 11, no. 7 (2020): 760. http://dx.doi.org/10.3390/genes11070760.

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The global spread of COVID-19, caused by pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for an imminent response from medical research communities to better understand this rapidly spreading infection. Employing multiple bioinformatics and computational pipelines on transcriptome data from primary normal human bronchial epithelial cells (NHBE) during SARS-CoV-2 infection revealed activation of several mechanistic networks, including those involved in immunoglobulin G (IgG) and interferon lambda (IFNL) in host cells. Induction of acute inflammatory

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Shaath, Hibah, Radhakrishnan Vishnubalaji, Eyad Elkord, and Nehad M. Alajez. "Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19." Cells 9, no. 11 (2020): 2374. http://dx.doi.org/10.3390/cells9112374.

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Cumulative data link cytokine storms with coronavirus disease 2019 (COVID-19) severity. The precise identification of immune cell subsets in bronchoalveolar lavage (BAL) and their correlation with COVID-19 disease severity are currently being unraveled. Herein, we employed iterative clustering and guide-gene selection 2 (ICGS2) as well as uniform manifold approximation and projection (UMAP) dimensionality reduction computational algorithms to decipher the complex immune and cellular composition of BAL, using publicly available datasets from a total of 68,873 single cells derived from two healt

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Shaath, Hibah, Radhakrishnan Vishnubalaji, Eyad Elkord, and Nehad M. Alajez. "Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19." Cells 9, no. 11 (2020): 2374. https://doi.org/10.5281/zenodo.13533357.

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(Uploaded by Plazi for the Bat Literature Project) Cumulative data link cytokine storms with coronavirus disease 2019 (COVID-19) severity. The precise identification of immune cell subsets in bronchoalveolar lavage (BAL) and their correlation with COVID-19 disease severity are currently being unraveled. Herein, we employed iterative clustering and guide-gene selection 2 (ICGS2) as well as uniform manifold approximation and projection (UMAP) dimensionality reduction computational algorithms to decipher the complex immune and cellular composition of BAL, using publicly available datasets from a

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Shaath, Hibah, Radhakrishnan Vishnubalaji, Eyad Elkord, and Nehad M. Alajez. "Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19." Cells 9, no. 11 (2020): 2374. https://doi.org/10.5281/zenodo.13533357.

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(Uploaded by Plazi for the Bat Literature Project) Cumulative data link cytokine storms with coronavirus disease 2019 (COVID-19) severity. The precise identification of immune cell subsets in bronchoalveolar lavage (BAL) and their correlation with COVID-19 disease severity are currently being unraveled. Herein, we employed iterative clustering and guide-gene selection 2 (ICGS2) as well as uniform manifold approximation and projection (UMAP) dimensionality reduction computational algorithms to decipher the complex immune and cellular composition of BAL, using publicly available datasets from a

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Čiučiulkaitė, Ieva, Winfried Siffert, Carina Elsner, et al. "Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in IFITM3 on the Antibody Response after Vaccination against COVID-19." Vaccines 11, no. 7 (2023): 1257. http://dx.doi.org/10.3390/vaccines11071257.

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The COVID-19 mRNA vaccine is the first mRNA vaccine approved for human administration by both the U.S. Food and Drug Administration and the European Medicines Agency. Studies have shown that the immune response and the decay of immunity after vaccination with the COVID-19 vaccines are variable within a population. Host genetic factors probably contribute to this variability. In this study, we investigated the effect of the single-nucleotide polymorphisms rs12252 and rs34481144 in the interferon-induced transmembrane protein (IFITM) 3 gene on the humoral immune response after vaccination agains

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Skov, Vibe, Caroline Riley, Mads Thomassen, et al. "The Impact of Interferon on Interferon-Related Genes in Polycythemia Vera and Allied Neoplasms." Blood 132, Supplement 1 (2018): 4328. http://dx.doi.org/10.1182/blood-2018-99-110602.

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Abstract Introduction: Using whole blood transcriptional profiling, we have previously shown deregulation of several interferon-stimulated genes (ISG) and deregulation of immune and inflammation genes in MPNs as well. Most lately, we have shown that deregulated HLA-genes are upregulated by interferon-alpha2 (IFN) treatment. Herein, we for the first time describe the landscape of ISGs during treatment with IFN, the aims being to describe if unique ISG transcriptional signatures might be elicited during IFN treatment with potential differences between subgroups. Methods: Eight patients with ET,

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Russo, Max, Sara T. Humes, Ariana M. Figueroa, et al. "Organochlorine Pesticide Dieldrin Suppresses Cellular Interferon-Related Antiviral Gene Expression." Toxicological Sciences 182, no. 2 (2021): 260–74. http://dx.doi.org/10.1093/toxsci/kfab064.

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Abstract Organochlorine pesticides (OCPs) are persistent pollutants linked to diverse adverse health outcomes. Environmental exposure to OCPs has been suggested to negatively impact the immune system but their effects on cellular antiviral responses remain unknown. Transcriptomic analysis of N27 rat dopaminergic neuronal cells unexpectedly detected high level expression of genes in the interferon (IFN)-related antiviral response pathways including the IFN-induced protein with tetratricopeptide repeats 1 and 2 (Ifit1/2) and the MX Dynamin Like GTPases Mx1 and Mx2. Interestingly, treatment of N2

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Zhang, Jiao, Si-yu Shao, Li-zu Li, Di Liu, and Xiu-qin Yang. "Molecular cloning and characterization of porcine interferon-induced protein with tetratricopeptide repeats (IFIT) 5." Canadian Journal of Animal Science 95, no. 4 (2015): 551–56. http://dx.doi.org/10.4141/cjas-2015-009.

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Zhang, J., Shao, S.-y., Li, L.-z., Liu, D. and Yang, X.-q. 2015. Molecular cloning and characterization of porcine interferon-induced protein with tetratricopeptide repeats (IFIT) 5. Can. J. Anim. Sci. 95: 551–556. Interferon-induced protein with tetratricopeptide repeats (IFIT) family members play important roles in host defense against viral infection. In the present study, the complete coding sequence (CDS) of porcine IFIT5 gene was cloned using molecular biology techniques, and the genomic structure was determined using the bioinformatic method. The porcine IFIT5 is located on chromosome 1

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Sun, Fang, Zhiqiang Xia, Yuewen Han, et al. "Topology, Antiviral Functional Residues and Mechanism of IFITM1." Viruses 12, no. 3 (2020): 295. http://dx.doi.org/10.3390/v12030295.

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Interferon-inducible transmembrane proteins (IFITM1/2/3) have been reported to suppress the entry of a wide range of viruses. However, their antiviral functional residues and specific mechanisms are still unclear. Here, we firstly resolved the topology of IFITM1 on the plasma membrane where N-terminus points into the cytoplasm and C-terminus resides extracellularly. Further, KRRK basic residues of IFITM1 locating at 62–67 of the conserved intracellular loop (CIL) were found to play a key role in the restriction on the Zika virus (ZIKV) and dengue virus (DENV). Similarly, KRRK basic residues of

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Kummer, Susann, Ori Avinoam, and Hans-Georg Kräusslich. "IFITM3 Clusters on Virus Containing Endosomes and Lysosomes Early in the Influenza A Infection of Human Airway Epithelial Cells." Viruses 11, no. 6 (2019): 548. http://dx.doi.org/10.3390/v11060548.

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Interferon-induced transmembrane proteins (IFITMs) have been shown to strongly affect influenza A virus (IAV) infectivity in tissue culture. Moreover, polymorphisms in IFITM3 have been associated with the severity of the disease in humans. IFITM3 appears to act early in the infection, but its mechanism of action and potential interactions with incoming IAV structures are not yet defined. Here, we visualized endogenous IFITM3 interactions with IAV in the human lung epithelial cell line A549 and in primary human airway epithelial cells employing stimulated emission depletion super-resolution mic

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Carr, Sarah N., Benjamin R. Crites, Harshraj Shinde, and Phillip J. Bridges. "Transcriptomic Changes in Response to Form of Selenium on the Interferon-Tau Signaling Mechanism in the Caruncular Tissue of Beef Heifers at Maternal Recognition of Pregnancy." International Journal of Molecular Sciences 24, no. 24 (2023): 17327. http://dx.doi.org/10.3390/ijms242417327.

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We have reported that selenium (Se) provided to grazing beef cattle in an inorganic (ISe) form versus a 1:1 mixture (MIX) of inorganic and organic (OSe) forms affects cholesterol biosynthesis in the corpus luteum (CL), the abundance of interferon tau (IFNτ) and progesterone (P4)-induced mRNAs in the caruncular (CAR) tissue of the endometrium, and conceptus length at maternal recognition of pregnancy (MRP). In this study, beef heifers were supplemented with a vitamin–mineral mix containing 35 ppm Se as ISe or MIX to achieve a Se-adequate status. Inseminated heifers were killed at MRP (d 17, n =

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Wang, Lei, Meng Shen, Jiale Liu, et al. "Effects of Dietary l-Glutamine Supplementation on the Intestinal Function and Muscle Growth of Piglets." Life 14, no. 3 (2024): 405. http://dx.doi.org/10.3390/life14030405.

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The aim of this study was to investigate the effects of dietary l-glutamine (Gln) supplementation on the morphology and function of the intestine and the growth of muscle in piglets. In this study, sixteen 21-day-old piglets were randomly divided into two groups: the Control group (fed a basal diet) and the Gln group (fed a basal diet supplemented with 0.81% Gln). Blood, gut, and muscle samples were collected from all piglets on Day 20 of the trial. Compared with the Control group, the supplementation of Gln increased (p < 0.05) the villus height, villus width, villus surface area, and vill

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Tirumurugaan, Krishnaswamy, Rahul Pawar, Gopal Dhinakar Raj, Arthanari Thangavelu, John Hammond, and Satya Parida. "RNAseq Reveals the Contribution of Interferon Stimulated Genes to the Increased Host Defense and Decreased PPR Viral Replication in Cattle." Viruses 12, no. 4 (2020): 463. http://dx.doi.org/10.3390/v12040463.

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Peste des petits ruminants virus (PPRV) is known to replicate in a wide variety of ruminants causing very species-specific clinical symptoms. Small ruminants (goats and sheep) are susceptible to disease while domesticated cattle and buffalo are dead-end hosts and do not display clinical symptoms. Understanding the host factors that influence differential pathogenesis and disease susceptibility could help the development of better diagnostics and control measures. To study this, we generated transcriptome data from goat and cattle peripheral blood mononuclear cells (PBMC) experimentally infecte

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Pasquero, Selina, Francesca Gugliesi, Matteo Biolatti, et al. "Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors." PLOS Pathogens 19, no. 12 (2023): e1011849. http://dx.doi.org/10.1371/journal.ppat.1011849.

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Herpes simplex virus 1 (HSV-1) is a neurotropic virus that remains latent in neuronal cell bodies but reactivates throughout an individual’s life, causing severe adverse reactions, such as herpes simplex encephalitis (HSE). Recently, it has also been implicated in the etiology of Alzheimer’s disease (AD). The absence of an effective vaccine and the emergence of numerous drug-resistant variants have called for the development of new antiviral agents that can tackle HSV-1 infection. Host-targeting antivirals (HTAs) have recently emerged as promising antiviral compounds that act on host-cell fact

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Dinwiddie, Darrell, Walter Dehority, Kurt C. Schwalm, Raymond J. Langley, Stephen A. Young, and Joshua L. Kennedy. "2249." Journal of Clinical and Translational Science 1, S1 (2017): 59. http://dx.doi.org/10.1017/cts.2017.213.

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OBJECTIVES/SPECIFIC AIMS: Respiratory viruses cause enormous medical burden, yet many of the specific virus and host genetic factors that impact pathogenesis are still largely unknown or poorly understood. To better understand the drivers of both acute clinical pathogenesis and long-term impacts, such as the development of asthma, we investigated the host response to respiratory syncytial virus (RSV) infections in pediatric patients. METHODS/STUDY POPULATION: We collected nasopharyngeal swabs from 32 pediatric patients with acute RSV infection. The swabs represented a mixed cell population inc

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Guo, Y., N. Jahmat, T. Van Shaik, et al. "124 CHANGES IN GENE EXPRESSION FOLLOWING EXPOSURE OF BOVINE ENDOMETRIAL EPITHELIAL CELLS (bEEC) TO ESCHERICHIA COLI LPS; THEIR POSSIBLE EFFECT ON IMPLANTATION." Reproduction, Fertility and Development 29, no. 1 (2017): 170. http://dx.doi.org/10.1071/rdv29n1ab124.

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Lipopolysaccharide (LPS) is a component of the outer membrane of gram-negative bacteria and is involved in postpartum uterine infection in cattle. Lipopolysaccharide causes inflammation of the endometrium and the activation of immune and pro-inflammatory pathways in uterine cells has been well documented. This study was performed to investigate the effects of LPS on epithelial cells from whole-genome information, and this abstract focuses on genes and pathways involved in the regulation of implantation. Following in vitro culture of bovine endometrial epithelial cells (bEEC), passage 4 epithel

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Low, Zhao Xuan, Osamu Kanauchi, Vunjia Tiong та ін. "The Antiviral Effects of Heat-Killed Lactococcus lactis Strain Plasma Against Dengue, Chikungunya, and Zika Viruses in Humans by Upregulating the IFN-α Signaling Pathway". Microorganisms 12, № 11 (2024): 2304. http://dx.doi.org/10.3390/microorganisms12112304.

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The growing risk of contracting viral infections due to high-density populations and ecological disruptions, such as climate change and increased population mobility, has highlighted the necessity for effective antiviral treatment and preventive measures against Dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus (ZIKV). Recently, there has been increasing attention on the use of probiotics as a potential antiviral option to reduce virus infections. The present study aimed to assess the immunomodulatory effects of heat-killed Lactococcus lactis strain plasma (LC-Plasma) on periphera

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Morodomi, Yosuke, Roberto Aiolfi, Eric Won, et al. "Sca-1 As a Marker of Stress-Induced Thrombopoiesis in Mice." Blood 134, Supplement_1 (2019): 1068. http://dx.doi.org/10.1182/blood-2019-127446.

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Introduction: It has been shown that megakaryocytes (MKs) can develop from a subset of MK-biased hematopoietic stem cells (HSCs). We also demonstrated that an active form of tyrosyl tRNA synthetase (YRS) has ex-translational activities that stimulate rapid platelet production in thrombocytopenic mice. Remarkably, YRS stimulates the development of MKs expressing the stem cell marker, Sca-1, and the monocyte/macrophage marker, F4/80. Thus, we hypothesized that YRS treatment mimics stress-induced megakaryopoiesis and Sca-1 may be a marker for MKs/platelets derived from MK-biased HSCs under inflam

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Fricke, Thomas, Sarah Schlagowski, Shanchuan Liu, et al. "Comparison of a Genotype 1 and a Genotype 2 Macaque Foamy Virus env Gene Indicates Distinct Infectivity and Cell-Cell Fusion but Similar Tropism and Restriction of Cell Entry by Interferon-Induced Transmembrane Proteins." Viruses 15, no. 2 (2023): 262. http://dx.doi.org/10.3390/v15020262.

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Foamy viruses (FVs) are naturally found in many different animals and also in primates with the notable exception of humans, but zoonotic infections are common. In several species, two different envelope (env) gene sequence clades or genotypes exist. We constructed a simian FV (SFV) clone containing a reporter gene cassette. In this background, we compared the env genes of the SFVmmu-DPZ9524 (genotype 1) and of the SFVmmu_R289hybAGM (genotype 2) isolates. SFVmmu_R289hybAGM env-driven infection was largely resistant to neutralization by SFVmmu-DPZ9524-neutralizing sera. While SFVmmu_R289hybAGM

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Zheng, Mei, Xuesen Zhao, Shuangli Zheng, et al. "Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusion." Emerging Microbes & Infections 9, no. 1 (2020): 1567–79. https://doi.org/10.5281/zenodo.13531742.

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(Uploaded by Plazi for the Bat Literature Project) Diverse SARS-like coronaviruses (SL-CoVs) have been identified from bats and other animal species. Like SARS-CoV, some bat SL-CoVs, such as WIV1, also use angiotensin converting enzyme 2 (ACE2) from human and bat as entry receptor. However, whether these viruses can also use the ACE2 of other animal species as their receptor remains to be determined. We report herein that WIV1 has a broader tropism to ACE2 orthologs than SARS-CoV isolate Tor2. Among the 9 ACE2 orthologs examined, human ACE2 exhibited the highest efficiency to mediate the infec

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Zheng, Mei, Xuesen Zhao, Shuangli Zheng, et al. "Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusion." Emerging Microbes & Infections 9, no. 1 (2020): 1567–79. https://doi.org/10.5281/zenodo.13531742.

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(Uploaded by Plazi for the Bat Literature Project) Diverse SARS-like coronaviruses (SL-CoVs) have been identified from bats and other animal species. Like SARS-CoV, some bat SL-CoVs, such as WIV1, also use angiotensin converting enzyme 2 (ACE2) from human and bat as entry receptor. However, whether these viruses can also use the ACE2 of other animal species as their receptor remains to be determined. We report herein that WIV1 has a broader tropism to ACE2 orthologs than SARS-CoV isolate Tor2. Among the 9 ACE2 orthologs examined, human ACE2 exhibited the highest efficiency to mediate the infec

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Lopez-Dominguez, R., J. Villatoro-Garcia, C. Marañón, et al. "OP0050 INCREASED IFITM GENE-SIGNATURES IN AGE-ASSOCIATED B AND PLASMA CELLS DEFINE NON-RESPONSE TO MYCOPHENOLATE MOFETIL IN SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 32.2–33. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4609.

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BackgroundSystemic Lupus Erythematosus (SLE) is a complex autoimmune disease that leads to significant worsening of quality of life and mortality. The enormous molecular heterogeneity of SLE is reflected in different clinical manifestations, disease progression and also in a different drug efficacy across patients[1]. Lupus nephritis (LN) is the most severe SLE manifestation with the potential of rapidly evolving into irreversible chronic kidney disease and kidney failure if not adequately followed and treated. Mycophenolate mofetil (MMF) is the most widely used first-line treatment for LN, be

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Carr, Sarah, Benjamin Crites, and Phillip Bridges. "11 Transcriptomic changes in response to form of selenium on the interferon-tau signaling mechanism in the caruncular tissue of beef heifers at maternal recognition of pregnancy." Journal of Animal Science 102, Supplement_1 (2024): 53–54. http://dx.doi.org/10.1093/jas/skae019.064.

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Abstract It is necessary to supplement selenium (Se) to the diet of beef cattle in regions where the soils and forages are deficient in this trace mineral. Supplementation with Se conventionally occurs using an inorganic form (ISe) although the organic forms (OSe) are available when cattle consume forage. Previously we have investigated the effects of supplemental Se as ISe, or a 1:1 mixture of ISe to OSe (MIX) on grazing beef cows and heifers and have observed significant effects on the corpus luteum (CL) and endometrium. The MIX form of Se increased systemic progesterone (P4) during the earl

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Prasad, Kartikay, Fatima Khatoon, Summya Rashid, et al. "Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective." International Journal of Biological Macromolecules 163 (June 7, 2020): 1–8. https://doi.org/10.5281/zenodo.14822512.

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(Uploaded by Plazi for the Bat Literature Project) The current pandemic of 2019 novel coronavirus disease (COVID-19) caused by a novel virus strain, 2019-nCoV/SARS-CoV-2 have posed a serious threat to global public health and economy. It is largely unknown how the human immune system responds to this infection. A better understanding of the immune response to SARS-CoV-2 will be important to develop therapeutics against COVID-19. Here, we have used transcriptomic profile of human alveolar adenocarcinoma cells (A549) infected with SARS-CoV-2 and employed a network biology approach to generate hu

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Zhen, Jing, Zhe Song, WenJie Su, Qing-Cui Zeng, JiaCen Li, and Qin Sun. "Integrated analysis of RNA-binding proteins in thyroid cancer." PLOS ONE 16, no. 3 (2021): e0247836. http://dx.doi.org/10.1371/journal.pone.0247836.

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Recently, the incidence of thyroid cancer (THCA) has been on the rise. RNA binding proteins (RBPs) and their abnormal expression are closely related to the emergence and pathogenesis of tumor diseases. In this study, we obtained gene expression data and corresponding clinical information from the TCGA database. A total of 162 aberrantly expressed RBPs were obtained, comprising 92 up-regulated and 70 down-regulated RBPs. Then, we performed a functional enrichment analysis and constructed a PPI network. Through univariate Cox regression analysis of key genes and found that NOLC1 (p = 0.036), RPS

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Assou, Said, Engi Ahmed, Lisa Morichon, et al. "The Transcriptome Landscape of the In Vitro Human Airway Epithelium Response to SARS-CoV-2." International Journal of Molecular Sciences 24, no. 15 (2023): 12017. http://dx.doi.org/10.3390/ijms241512017.

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Airway–liquid interface cultures of primary epithelial cells and of induced pluripotent stem-cell-derived airway epithelial cells (ALI and iALI, respectively) are physiologically relevant models for respiratory virus infection studies because they can mimic the in vivo human bronchial epithelium. Here, we investigated gene expression profiles in human airway cultures (ALI and iALI models), infected or not with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using our own and publicly available bulk and single-cell transcriptome datasets. SARS-CoV-2 infection significantly increas

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Dey, Aonkon, Rupa Narayan, Neal Smith, et al. "Single-Cell Multiomics Analysis Reveals Potential Drivers of Response to the Anti-TIM3 Inhibitor Sabatolimab Combined with Azacitidine in MDS and CMML." Blood 142, Supplement 1 (2023): 4319. http://dx.doi.org/10.1182/blood-2023-189858.

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Background The median survival for patients with newly diagnosed (ND) higher risk myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) remains poor. The potential curability of MDS and CMML with allogeneic hematopoietic stem cell transplantation supports the concept of anti-tumor immunity and has led to interest in evaluating immune-based therapeutic approaches in myeloid neoplasms. The immune checkpoint molecule TIM-3 (encoded by the gene HAVCR2) is a target of interest in myeloid neoplasms given its expression on leukemic stem cells as well as several subsets of immune c

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Patel, Parasvi S., Jun Tian, Ferran Fece de la Cruz, et al. "Abstract LB366: KRASG12C inhibition enhances immunogenicity in KRASG12C-mutant colorectal cancer." Cancer Research 84, no. 7_Supplement (2024): LB366. http://dx.doi.org/10.1158/1538-7445.am2024-lb366.

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Abstract RAS mutations are among the most prevalent oncogenic mutations, found in approximately 20% of human cancers. KRAS, the predominantly mutated isoform of RAS, is mutated in 40% of colorectal cancer (CRC) and leads to constitutive activation of the MAPK pathway and other downstream effectors. Despite recent FDA approval for KRASG12C selective inhibitor in non-small cell lung cancer, the response rate in CRC is below 20%, posing a challenge for treatment of these tumors. Several studies have implicated oncogenic KRAS signaling in creating an immunosuppressive tumor microenvironment; there

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Yount, Jacob S., Ashley Zani, and Adam D. Kenney. "Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice." Journal of Immunology 208, no. 1_Supplement (2022): 51.17. http://dx.doi.org/10.4049/jimmunol.208.supp.51.17.

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Abstract Interferon-induced transmembrane protein 3 (IFITM3) is a host antiviral protein that alters cell membranes to block fusion of viruses. Published reports have identified conflicting pro- and anti-viral effects of IFITM3 on SARS-CoV-2 in cultured cells, and its impact on viral pathology in vivo remains unclear. Here, we show that IFITM3 knockout (KO) mice infected with mouse-adapted SARS-CoV-2 experienced extreme weight loss and lethality, while wild type (WT) mice lost only 10% of their body weight and recovered. KO mice had higher lung viral titers and increases in lung inflammatory c

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