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Articles de revues sur le sujet « IKRK »

Auteur : Grafiati

Publié le 25 juillet 2024

Mis à jour le 31 juillet 2025

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1

Kesselring, J. "Das Internationale Komitee vom Roten Kreuz." Nervenheilkunde 35, no. 06 (2016): 378–84. http://dx.doi.org/10.1055/s-0037-1616400.

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ZusammenfassungDas Internationale Komitee vom Roten Kreuz (IKRK) war Initiant der gesamten Rotkreuzbewegung und wurde 1863 in Genf gegründet. Heute ist es weltweit im Einsatz mit über 15 000 Mitarbeitern weltweit vor allem in bewaffneten Konflikten und als Hüter des Humanitären Völkerechtes. Seine Tätigkeit ist eine praktische Anwendung des Gedankengutes der Resilienz, d. h. der aufrichtenden Kräfte, die in verschiedenen Dimensionen so wichtig sind.

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Khagoory, Fatima, and Ali Rahim. "Estimation of Coda Q Wave Attenuation Factors for Northern Iraq." Iraqi Geological Journal 56, no. 1A (2023): 149–60. http://dx.doi.org/10.46717/igj.56.1a.11ms-2023-1-23.

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The coda wave decay method was used to estimate the quality factor from the coda wave amplitude decay rate for the broadband seismic stations in northern Iraq using a single back-scattering model. The study aims to calculate the attenuation factor to comprehend the details of the structure of the earth's crust in the study area. The study was conducted using data from the Mesopotamian Network and the Iraqi Meteorological Organization and Seismology from 2007 to 2021. The selected earthquakes have magnitudes ranging from 4 to 6.1 ML and epicentral distances of less than < 100 km. Seventy sev

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Harroff-Tavel, Marion. "Strategie der Humanitären Aktion des IKRK gegenüber Konflikten des 21. Jahrhunderts." Schweizerisches Jahrbuch für Entwicklungspolitik, no. 18 (January 1, 1999): 51–61. http://dx.doi.org/10.4000/sjep.632.

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gseUr, dqekj. "unh rVca/kks dh lqj{kk dk Lrj Kkr djkus dk HK ekMy." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES 5, no. 7 (2018): 168–71. https://doi.org/10.5281/zenodo.1307657.

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unh&ukyksa dh ck<+ ls vkl&ikl fLFkr cLrh vkSj [ksrksadks Hkkjh uqdlku igqprk gSA mik;Lo#i unh ds ,d ;k nksuks fdukjksa ij rVca/k cuk fn;s tkrs gS]ftlls unh dk ikuh fdukjs ls ckgj ugh fudy ikrk vkSj cgqr gn rd ck<+ ls tu&/ku dh gkfu ugh gksrhA burVca/k dh lqj{kk rFkk LFkkf;Ro ije vko’;d gksrk gSA rVca/kksa dk LFkkf;Ro vusd dkjdks ij fuHkZj djrk gS ftlls buds lqjf{kr gksus dk Lrj r; djuk vR;Uu nq#g rFkk ifjfLFkrtU; gksrk gSA bl fo”k; ij xgu rFkk lexz v/;;u vkSj ‘kks/k ugh gks ik;s gSA v/;;u ds vHkko esa rVca/kks dh leqfpr lqj{kk ugha gks ikrh gSA bl ‘kks

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GUHATHAKURTA, PULAK, AJIT TYAGI, and B. MUKHOPADHYAY. "Climatology at any point : A neural network solution." MAUSAM 64, no. 2 (2021): 231–50. http://dx.doi.org/10.54302/mausam.v64i2.682.

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lHkh mi;ksxdrkZvksa] ;kstuk cukus okyksa] vkink izca/ku dkfeZdksa] i;ZVu vkfn }kjk rkieku] vf/kdre rkieku] U;wure rkieku] ok;qeaMyh; nkc] o"kkZ vkfn tSls ekSle izkpyksa dh tyok;q foKku ij lwpukvksa dh mUur tkudkjh dh vR;kf/kd ek¡x jgh gSA fdlh LFkku fo'ks"k esa os/k’kkyk ds vHkko vkSj dHkh&dHkh nh?kZ vof/k ds igys ds vk¡dM+ksa dh vuqiyC/krk ds dkj.k ekSle foKku leqnk; ml LFkku fo’ks"k ds fy, visf{kr lwpukvksa dks miyC/k ugha djk ikrk gSA bl 'kks/k i= esa LFkkfud varosZ’ku ds {ks= esa U;wjy usVodZ ds rqyukRed u, vuqiz;ksx crk, x, gSaA iwjs ckjg eghuksa ds vf/kdre vkSj U;wure nksuksa rkiekuk

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RAO, Y. V. RAMA, H. R. HATWAR, and GEETA AGNIHOTRI. "Tropical cyclones prediction by numerical models in India Meteorological Department." MAUSAM 57, no. 1 (2021): 47–60. http://dx.doi.org/10.54302/mausam.v57i1.454.

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lkj & bl 'kks/k&Ik= esa Hkkjr ekSle foKku foHkkx ¼Hkk- ekS- fo- fo-½ esa viukbZ xbZ pØokr izfr:fir djus dh dfYir rduhdksa ij ppkZ dh xbZ gSA vDrwcj 1999 esa mM+hlk esa vk, egkpØokr ds izkjfEHkd {ks=ksa esa dkYifud Hkzfeyrk dk mi;ksx djds] pØokr ds fof’k"V ekWMy] Doklh ySaxjfx;u ekWMy ¼D;w- ,y- ,e-½ ls 72 ?kaVs ds iwokZuqeku vkSj Hkkjr ekSle foKku foHkkx ds lhfer {ks= fun’kZ ¼,y- ,- ,e-½ ls 36 ?kaVs ds iwokZuqeku izfr:fir fd, x,A bl 'kks/k esa] 26 ls 28 vDrwcj rd dh izkjafHkd fLFkfr;ksa ds vk/kkj ij D;w- ,y- ,e- ls pØokr ds ekxZ ds iwokZuqeku dh vkSlr =qfV;k¡ 24 ?kaVs ds fy, 21 fd-eh-]

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Fahma, Nabilatul, and Trianingsih Eni Lestari. "PENERAPAN ANALISIS DISKRIMINAN LINIER ROBUST DALAM PENGKLASIFIKASIAN INDEKS KEPEDULIAN TERHADAP ISU KEPENDUDUKAN (IKIK)." Jurnal Kajian Matematika dan Aplikasinya (JKMA) 3, no. 1 (2022): 30. http://dx.doi.org/10.17977/um055v3i12022p30-36.

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Abstract Robust linear discriminant analysis is used to classify data that contains outlier by replacing classical parameters in linear discriminant analysis with robust parameters. This study aims to classify the Index of Concern for Population Issues (IKIK) of 34 provinces in 2020 into two categories namely target fulfilled IKIK and target not fulfilled IKIK using robust linear discriminant analysis. The independen variabels used are quantity dimensions (X_1), quality dimensions (X_2), mobility dimensions (X_3), and environment dimensions (X_4). The results obtained are 17 provinces were cat

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Kamal, Abdol Moghset Bani, and Wahabuddin Ra’ees. "Iran’s Aid Diplomacy in Afghanistan: The Role of Imam Khomeini Relief Committee." Contemporary Review of the Middle East 5, no. 4 (2018): 308–26. http://dx.doi.org/10.1177/2347798918795369.

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This study aims at examining the Islamic Republic of Iran’s “aid diplomacy” officially referred to as “support diplomacy” and focuses on the Imam Khomeini Relief Committee (IKRC), a charity organization which is functioning as the main vehicle. The IKRC is highly active in many poor countries and this study focuses on the activities, strategies, and achievements of the IKRC in Afghanistan. The study among others finds that Iran is using rigorous aid diplomacy to penetrate into the downtrodden layers of Afghan society. The foundational principles of the IKRC suggest that this institution is fun

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Liaudanskaitė, Deimantė, and Lina Stungienė. "The effect of classic facial massage with caviar extract on mature female facial skin." Applied Scientific Research 2, no. 2 (2023): 204–14. http://dx.doi.org/10.56131/tmt.2023.2.2.173.

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The article analyzes the effect of classic facial massage with caviar extract on mature female skin. The criteria for evaluating the condition of the skin are presented: the degree of wrinkles, the length, width, depth of wrinkles, keratin level, skin elasticity, turgor, tone. The charts show the most significant changes depending on the procedures performed. Keywords: cosmetic massage, mature skin, caviar extract.

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Huynh, Q. Khai, Nandini Kishore, Sumathy Mathialagan, Ann M. Donnelly та Catherine S. Tripp. "Kinetic Mechanisms of IκB-related Kinases (IKK) Inducible IKK and TBK-1 Differ from IKK-1/IKK-2 Heterodimer". Journal of Biological Chemistry 277, № 15 (2002): 12550–58. http://dx.doi.org/10.1074/jbc.m111526200.

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Hehner, Steffen P., Thomas G. Hofmann, Alexej Ushmorov та ін. "Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex". Molecular and Cellular Biology 20, № 7 (2000): 2556–68. http://dx.doi.org/10.1128/mcb.20.7.2556-2568.2000.

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ABSTRACT The phosphorylation of IκB by the multiprotein IκB kinase complex (IKC) precedes the activation of transcription factor NF-κB, a key regulator of the inflammatory response. Here we identified the mixed-lineage group kinase 3 (MLK3) as an activator of NF-κB. Expression of the wild-type form of this mitogen-activated protein kinase kinase kinase (MAPKKK) induced nuclear immigration, DNA binding, and transcriptional activity of NF-κB. MLK3 directly phosphorylated and thus activated IκB kinase alpha (IKKα) and IKKβ, revealing its function as an IκB kinase kinase (IKKK). MLK3 cooperated wi

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Liu, Fei, Yifeng Xia, Aaron S. Parker, and Inder M. Verma. "IKK biology." Immunological Reviews 246, no. 1 (2012): 239–53. http://dx.doi.org/10.1111/j.1600-065x.2012.01107.x.

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Field, N. "KSHV vFLIP binds to IKK- to activate IKK." Journal of Cell Science 116, no. 18 (2003): 3721–28. http://dx.doi.org/10.1242/jcs.00691.

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Sihombing, Pardomuan Robinson, Widdia Angraini, Busminoloan Busminoloan, and Usep Nugraha. "Faktor Yang Mempengaruhi Kualitas dan Indeks Pembangunan Ketenagakerjaan di Indonesia di Masa Pandemi 2020." Khatulistiwa: Jurnal Pendidikan dan Sosial Humaniora 2, no. 3 (2022): 52–60. http://dx.doi.org/10.55606/khatulistiwa.v2i3.384.

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Penelitian ini bertujuan mengetahui pengaruh Indeks Kompensasi Tenaga Kerja (IKTK), Indeks Pembangunan Manusia (IPM), Indeks Pembangunan Ekonomi Insklusif (IPEI) terhadap Indeks Pembangunan Ketenagakerjaan (IPK) melalui Indeks Kualitas Pekerjaan (IKP). Data yang digunakan berasal dari Badan Pusat Statistik, Bappenas dan Kemenaker menggunakan data 34 Provinsi Tahun 2020. Model yang digunakan adalah model SEM PLS dengan bantuan software SmartPLS 3.8. Hasil yang didapat IKTK, IPM, IPEI berpengaruh langsung terhadap IKP. Di sisi lain IKTK, IPM, IPEI berpengaruh tidak langsung terhadap IPK melalui

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Láng, Eszter, and Gergely Makláry. "Sziámi ikrek, avagy kölcsönös egymásrautaltság: az EU – USA transzatlanti kapcsolatok gazdasági dimenziói." Competitio 3, no. 3 (2004): 83–100. http://dx.doi.org/10.21845/comp/2004/3/5.

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Koppe, Reisinger, Wehr, et al. "An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration." Cancers 11, no. 7 (2019): 999. http://dx.doi.org/10.3390/cancers11070999.

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The IκBKinase (IKK) complex represents a central signaling nexus in the TNF-dependent activation of the pro-inflammatory NF-κB pathway. However, recent studies suggested that the distinct IKK subunits (IKK, IKK, and NEMO) might withhold additional NF-κB-independent functions in inflammation and cancer. Here, we generated mice lacking all three IKK subunits in liver parenchymal cells (LPC) (IKK//NEMOLPC-KO) and compared their phenotype with mice lacking both catalytic subunits (IKK/LPC-KO), allowing to functionally dissect putative I-κB-Kinase-independent functions of the regulatory subunit NEM

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Aupperle, Karlfried R., Brydon L. Bennett, David L. Boyle, Paul-Peter Tak, Anthony M. Manning та Gary S. Firestein. "NF-κB Regulation by IκB Kinase in Primary Fibroblast-Like Synoviocytes". Journal of Immunology 163, № 1 (1999): 427–33. http://dx.doi.org/10.4049/jimmunol.163.1.427.

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Abstract NF-κB is a key regulator of inflammatory gene transcription and is activated in the rheumatoid arthritis (RA) synovium. In resting cells, NF-κB is retained as an inactive cytoplasmic complex by its inhibitor, IκB. Phosphorylation of IκB targets it for proteolytic degradation, thereby releasing NF-κB for nuclear translocation. Recently, two related IκB kinases (IKK-1 and IKK-2) were identified in immortalized cell lines that regulate NF-κB activation by initiating IκB degradation. To determine whether IKK regulates NF-κB in primary cells isolated from a site of human disease, we charac

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Ayu Arwati, I. Gusti, Euis Nina Saparina, and Nur Endah Retno Wuryandari. "OVERCOMING OBSTACLES IN THE DEVELOPMENT OF IKRT / UMK THROUGH APPLICATION OF APPROPRIATE TECHNOLOGY." Dinasti International Journal of Digital Business Management 1, no. 3 (2020): 386–93. http://dx.doi.org/10.31933/dijdbm.v1i3.242.

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The SME sector that has an important role in the Indonesian industry is the small and home industry (IKRT) or micro and small businesses (MSME). In everyday life, washing clothes and washing the house is an activity that is usually done by everyone, especially by the home industry. IKRT (UMK) Suradita RW 09 Suradita Indah Complex, is IKRT (UMK) in the Suradita sub-district, which produces green cleaning products guided by Universitas Mercu Buana lecturers who have been operating for one year. IKRT (UMK) was established to increase the knowledge of housewives who live in RW 09, where production

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Lee, Frank S., Robert T. Peters, Luan C. Dang та Tom Maniatis. "MEKK1 activates both IκB kinase α and IκB kinase β". Proceedings of the National Academy of Sciences 95, № 16 (1998): 9319–24. http://dx.doi.org/10.1073/pnas.95.16.9319.

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A critical step in the signal-induced activation of the transcription factor NF-κB is the site-specific phosphorylation of its inhibitor, IκB, that targets the latter for degradation by the ubiquitin–proteasome pathway. We have previously shown that mitogen-activated protein kinase/ERK kinase kinase 1 (MEKK1) can induce both this site-specific phosphorylation of IκBα at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IκB kinase complex in vitro. Subsequently, others have identified two proteins, IκB kinase α (IKK-α) and IκB kinase β (IKK-β), that are present in a tumor ne

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Hacker, H., and M. Karin. "Regulation and Function of IKK and IKK-Related Kinases." Science's STKE 2006, no. 357 (2006): re13. http://dx.doi.org/10.1126/stke.3572006re13.

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Akbar, Yuma, Iim Muhaemin Abdul Azis, Aulia Farhani, and Reda Hayati Nufus. "Rancang Bangun Sistem Informasi Kas pada Ikatan Remaja Pesantren Akmaliah Berbasis Web." AJAD : Jurnal Pengabdian kepada Masyarakat 4, no. 1 (2024): 148–55. http://dx.doi.org/10.59431/ajad.v4i1.288.

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Ikatan Remaja Pondok Pesantren Akmaliah (IKRA) is a management organization within the Akmaliah Islamic Boarding School. Akmaliah Islamic Boarding School is a place for teaching or studying Islamic teachings. Based on information from one of the administrators of the IKRA organization, there are problems with the management system and cash contributions at this organization called IKRA. In the previous cash system, recording of outgoing and incoming funds was still done manually and information about the recording was still done manually, namely through the WhatsApp Group social media applicat

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Zhang, Shetuan. "Isolation and characterization of IKr in cardiac myocytes by Cs+ permeation." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 3 (2006): H1038—H1049. http://dx.doi.org/10.1152/ajpheart.00679.2005.

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Isolation of the rapidly activating delayed rectifier potassium current ( IKr) from other cardiac currents has been a difficult task for quantitative study of this current. The present study was designed to separate IKr using Cs+ in cardiac myocytes. Cs+ have been known to block a variety of K+ channels, including many of those involved in the cardiac action potential such as inward rectifier potassium current IK1 and the transient outward potassium current Ito. However, under isotonic Cs+ conditions (135 mM Cs+), a significant membrane current was recorded in isolated rabbit ventricular myocy

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Watanabe, Ryo, Ryoko Wakizono Azuma, Jun-ichi Suzuki та ін. "Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation". American Journal of Physiology-Heart and Circulatory Physiology 305, № 12 (2013): H1761—H1771. http://dx.doi.org/10.1152/ajpheart.00159.2013.

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NF-κB, which is activated by the inhibitor of NF-κB kinase (IKK), is involved in the progression of inflammatory disease. However, the effect of IKK inhibition on the progression of myocarditis is unknown. We examined the effect of IKK inhibition on the progression of myocarditis. Lewis rats were immunized with porcine cardiac myosin to induce experimental autoimmune myocarditis (EAM). We administered the IKK inhibitor (IMD-0354; 15 mg·kg−1·day−1) or vehicle to EAM rats daily. Hearts were harvested 21 days after immunization. Although the untreated EAM group showed increased heart weight-to-bo

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Shinohara, Hisaaki, Tomoharu Yasuda, Yuichi Aiba та ін. "PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1". Journal of Experimental Medicine 202, № 10 (2005): 1423–31. http://dx.doi.org/10.1084/jem.20051591.

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The B cell antigen receptor (BCR)–mediated activation of IκB kinase (IKK) and nuclear factor–κB require protein kinase C (PKC)β; however, the mechanism by which PKCβ regulates IKK is unclear. Here, we demonstrate that another protein kinase, TGFβ-activated kinase (TAK)1, is essential for IKK activation in response to BCR stimulation. TAK1 interacts with the phosphorylated CARMA1 (also known as caspase recruitment domain [CARD]11, Bimp3) and this interaction is mediated by PKCβ. IKK is also recruited to the CARMA1–Bcl10–mucosal-associated lymphoid tissue 1 adaptor complex in a PKCβ-dependent ma

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Nemoto, Shino, Joseph A. DiDonato та Anning Lin. "Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase". Molecular and Cellular Biology 18, № 12 (1998): 7336–43. http://dx.doi.org/10.1128/mcb.18.12.7336.

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ABSTRACT IκB kinases (IKKα and IKKβ) are key components of the IKK complex that mediates activation of the transcription factor NF-κB in response to extracellular stimuli such as inflammatory cytokines, viral and bacterial infection, and UV irradiation. Although NF-κB-inducing kinase (NIK) interacts with and activates the IKKs, the upstream kinases for the IKKs still remain obscure. We identified mitogen-activated protein kinase kinase kinase 1 (MEKK1) as an immediate upstream kinase of the IKK complex. MEKK1 is activated by tumor necrosis factor alpha (TNF-α) and interleukin-1 and can potenti

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Antonia, Ricardo J., and Albert S. Baldwin. "IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells." Science Signaling 11, no. 538 (2018): eaan5850. http://dx.doi.org/10.1126/scisignal.aan5850.

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The 5′ AMP-activated protein kinase (AMPK) is an energy sensor that is activated upon phosphorylation of Thr172 in its activation loop by the kinase LKB1, CAMKK2, or TAK1. TAK1-dependent AMPK phosphorylation of Thr172 is less well characterized than phosphorylation of this site by LKB1 or CAMKK2. An important target of TAK1 is IκB kinase (IKK), which controls the activation of the transcription factor NF-κB. We tested the hypothesis that IKK acted downstream of TAK1 to activate AMPK by phosphorylating Thr172. IKK was required for the phosphorylation of Thr172 in AMPK in response to treatment w

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L, Anitha, and Sugunan Sinoy. "Ikk-Alpha Role in Colorectal Cancer - A Contemporary Anti-Cancer Target For Prioritising Colorectal Cancer Research." Der Pharma Chemica 14, no. 5 (2022): 6. https://doi.org/10.5281/zenodo.10804095.

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The IKK-alpha, B kinase, or IKK enzyme complex is involved in the propagation of the cellular response to inflammation. The upstream NF-B signal transduction cascade includes the IB kinase enzyme complex. By masking the nucleus localization signals (NLS) of NF-B proteins and keeping them sequestered in an inactive state in the cytoplasm, the IKB alpha (inhibitor of nuclear factor kappa B) protein inactivates the NF-B transcription factor. IKK phosphorylates the inhibitory IB protein in particular. The separation of IB from NF-B occurs as a result of this phosphorylation. Now that NF-B is liber

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Gósy, Mária, and Márta Pregitzer. "Beszédészlelés és beszédmegértés ikreknél és nem ikreknél." Anyanyelv-pedagógia 12, no. 3 (2019): 5–17. http://dx.doi.org/10.21030/anyp.2019.3.1.

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A kutatási eredmények a genetikai tényező mellett a környezeti hatás meghatározó szerepét igazolják a nyelvelsajátításban. Az ikrek anyanyelvi jellemzőinek összevető vizsgálata nem ikergyermekekéivel információt nyújthat az eltérő környezeti hatás következményeiről. Kutatásunkban a beszédészlelés és a beszédmegértés két-két folyamatát elemeztük közel 400 gyermek (5–9 évesek) teszteléses vizsgálata alapján. Az eredmények szerint a beszédhang-differenciálásban jóformán nincs különbség az ikrek és a nem ikrek között, míg a szeriális észlelésben csak a 7 és a 8 évesek esetében nem volt jelentős el

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Hua, Fei, David C. Johns, and Robert F. Gilmour. "Suppression of electrical alternans by overexpression of HERG in canine ventricular myocytes." American Journal of Physiology-Heart and Circulatory Physiology 286, no. 6 (2004): H2342—H2351. http://dx.doi.org/10.1152/ajpheart.00793.2003.

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Suppression of electrical alternans may be antiarrhythmic. Our previous computer simulations have suggested that increasing the rapid component of the delayed rectifier K+ current ( IKr) suppresses alternans. To test this hypothesis, IKr in isolated canine ventricular myocytes was increased by infection with an adenovirus containing the gene for the pore-forming domain of IKr [human ether-a-go-go gene (HERG)]. With the use of the perforated or whole cell patch-clamp technique, action potentials recorded at different pacing cycle lengths (CLs) were applied to the myocytes as the command wavefor

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Zhu, Haijuan, Jinbao Wang та Lihua Huang. "Dexmedetomidine relieves inflammatory response in rats with acute spinal cord injury through IKK/NF-κB signaling pathway". Tropical Journal of Pharmaceutical Research 21, № 3 (2022): 543–48. http://dx.doi.org/10.4314/tjpr.v21i3.13.

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Purpose: To examine the effect of dexmedetomidine (DEX) on inflammatory response in spinal cord damage, and involvement of IKK/NF-κB signaling pathway in the process.Methods: Sixty healthy male Wistar rats were selected and randomly divided into sham, control, IKK inhibition, and DEX groups. Rat hind limb motor function in each group at 1, 24 and 48 h after surgery was determined using Basso Beattie Bresnahan (BBB) method, while Western blot assay was used to evaluate the protein expression levels of IL-1β, IKK and NF-κB in spinal cord tissue.Results: In DEX rat group, neuromotor function at 2

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Devin, Anne, Yong Lin, Shoji Yamaoka, Zhiwei Li, Michael Karin та Zheng-gang Liu. "The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF". Molecular and Cellular Biology 21, № 12 (2001): 3986–94. http://dx.doi.org/10.1128/mcb.21.12.3986-3994.2001.

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ABSTRACT The activation of IκB kinase (IKK) is a key step in the nuclear translocation of the transcription factor NF-κB. IKK is a complex composed of three subunits: IKKα, IKKβ, and IKKγ (also called NEMO). In response to the proinflammatory cytokine tumor necrosis factor (TNF), IKK is activated after being recruited to the TNF receptor 1 (TNF-R1) complex via TNF receptor-associated factor 2 (TRAF2). We found that the IKKα and IKKβ catalytic subunits are required for IKK-TRAF2 interaction. This interaction occurs through the leucine zipper motif common to IKKα, IKKβ, and the RING finger domai

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Foley, J. F. "IKK Targets PI3K." Science Signaling 5, no. 218 (2012): ec100-ec100. http://dx.doi.org/10.1126/scisignal.2003101.

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Foley, J. F. "IKK Goes BAD." Science Signaling 6, no. 260 (2013): ec31-ec31. http://dx.doi.org/10.1126/scisignal.2004004.

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Bohn Stafleu van Loghum. "Onduidelijkheid over IKK." Management Kinderopvang 24, no. 1 (2018): 33. http://dx.doi.org/10.1007/s41190-018-0008-4.

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HL. "IKK gegen Einheitsbeitrag." Der Hausarzt 49, no. 15 (2012): 12. http://dx.doi.org/10.1007/s15200-012-0805-y.

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Barral, Yann-Stanislas H. M., Liudmila Polonchuk, Michael Clerx, David J. Gavaghan, Gary R. Mirams, and Ken Wang. "Comparison of in silico predictions of action potential duration in response to inhibition of IKr and ICaL with new human ex vivo recordings." PLOS Computational Biology 21, no. 7 (2025): e1012913. https://doi.org/10.1371/journal.pcbi.1012913.

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During drug development, candidate compounds are extensively tested for proarrhythmic risk and in particular risk of Torsade de Pointes (TdP), as indicated by prolongation of the QT interval. Drugs that inhibit the rapid delayed rectifier K+ current (IKr) can prolong the action potential duration (APD) and thereby the QT interval, and so are routinely rejected. However, simultaneous inhibition of the L-type Ca2+ current (ICaL) can mitigate the effect of IKr inhibition, so that including both effects can improve test specificity. Mathematical models of the action potential (AP) can be used to p

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Opgenorth, Dawn, Liza Bialy, Kristin Robertson, et al. "Key performance indicators for acute intermittent kidney replacement therapy in critically ill patients: a protocol for a systematic review." BMJ Open 15, no. 4 (2025): e093334. https://doi.org/10.1136/bmjopen-2024-093334.

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IntroductionThere have been previous initiatives to identify key performance indicators (KPIs) for continuous kidney replacement therapy. However, no formal reviews of the evidence for KPIs of intermittent kidney replacement therapy (IKRT) have been conducted. This systematic review will appraise the evidence for KPIs of IKRT in critically ill patients and is part of the DIALYZING WISELY (NCT05186636) programme which aims to improve the performance of acute renal replacement therapy in intensive care units by aligning local practices with evidence-based best practices.Methods and analysisOvid

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Purcell, Nicole H., Chenfei Yu, Daoyao He та ін. "Activation of NF-κB by hepatitis B virus X protein through an IκB kinase-independent mechanism". American Journal of Physiology-Gastrointestinal and Liver Physiology 280, № 4 (2001): G669—G677. http://dx.doi.org/10.1152/ajpgi.2001.280.4.g669.

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pX, the hepatitis B virus-encoded transcription coactivator, is involved in viral infection in vivo. pX stimulates the activity of several transcription factors including nuclear factor-κB (NF-κB), but the mechanism of activation is poorly understood. The IκB kinase complex (IKK) mediates activation of NF-κB in response to various extracellular stimuli, including inflammatory cytokines like tumor necrosis factor and interleukin 1, human T cell lymphoma virus 1 Tax protein, and tumor promoters like phorbol esters. It is not known whether IKK also mediates activation of NF-κB by pX. Here we repo

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Trushin, Sergey A., Kevin N. Pennington, Eva M. Carmona та ін. "Protein Kinase Cα (PKCα) Acts Upstream of PKCθ To Activate IκB Kinase and NF-κB in T Lymphocytes". Molecular and Cellular Biology 23, № 19 (2003): 7068–81. http://dx.doi.org/10.1128/mcb.23.19.7068-7081.2003.

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ABSTRACT NF-κB is an ubiquitous transcription factor that is a key in the regulation of the immune response and inflammation. T-cell receptor (TCR) cross-linking leads to NF-κB activation, an IκB kinase (IKK)-dependent process. However, the upstream kinases that regulate IKK activity following TCR activation remain to be fully characterized. Herein, we demonstrate using genetic analysis, pharmacological inhibition, and RNA interference (RNAi) that the conventional protein kinase C (PKC) isoform PKCα, but not PKCβ1, is required for the activation of the IKK complex following T-cell activation t

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Sanguinetti, M. C., and N. K. Jurkiewicz. "Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents." Journal of General Physiology 96, no. 1 (1990): 195–215. http://dx.doi.org/10.1085/jgp.96.1.195.

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An envelope of tails test was used to show that the delayed rectifier K+ current (IK) of guinea pig ventricular myocytes results from the activation of two outward K+ currents. One current was specifically blocked by the benzenesulfonamide antiarrhythmic agent, E-4031 (IC50 = 397 nM). The drug-sensitive current, "IKr" exhibits prominent rectification and activates very rapidly relative to the slowly activating drug-insensitive current, "IKs." IKs was characterized by a delayed onset of activation that occurs over a voltage range typical of the classically described cardiac IK. Fully activated

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Kearly, Alyssa, Kristina Ottens, Michael C. Battaglia, Anne B. Satterthwaite, and Lee Ann Garrett-Sinha. "B Cell Activation Results in IKK-Dependent, but Not c-Rel- or RelA-Dependent, Decreases in Transcription of the B Cell Tolerance-Inducing Gene Ets1." ImmunoHorizons 6, no. 11 (2022): 779–89. http://dx.doi.org/10.4049/immunohorizons.2100065.

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Abstract Ets1 is a key transcription factor in B cells that is required to prevent premature differentiation into Ab-secreting cells. Previously, we showed that BCR and TLR signaling downregulate Ets1 levels and that the kinases PI3K, Btk, IKK, and JNK are required for this process. PI3K is important in activating Btk by generating the membrane lipid phosphatidylinositol (3,4,5)-trisphosphate, to which Btk binds via its PH domain. Btk in turn is important in activating the IKK kinase pathway, which it does by activating phospholipase Cγ2→protein kinase Cβ signaling. In this study, we have furt

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Tsai, Julie, Rianna Zhang, Wei Qiu, Qiaozhu Su, Mark Naples та Khosrow Adeli. "Inflammatory NF-κB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production". American Journal of Physiology-Gastrointestinal and Liver Physiology 296, № 6 (2009): G1287—G1298. http://dx.doi.org/10.1152/ajpgi.90540.2008.

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Insulin-resistant states are commonly associated with chronic inflammation and hepatic overproduction of apolipoprotein B100 (apoB100), leading to hypertriglyceridemia and a metabolic dyslipidemic profile. Molecular mechanisms linking hepatic inflammatory cascades and the pathways of apoB100-lipoprotein production are, however, unknown. In the present study, we employed a diet-induced, insulin-resistant hamster model, as well as cell culture studies, to investigate the potential link between activation of hepatic inflammatory nuclear factor-κB (NF-κB) signaling cascade and the synthesis and se

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Zerzová, J., and S. Šebestová. "Příležitosti k rozvíjení interkulturní komunikační kompetence v kontextu řečových dovedností: IVŠV videostudie anglického jazyka." Pedagogická orientace 24, no. 3 (2014): 394–422. http://dx.doi.org/10.5817/pedor2014-3-394.

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Empirická studie je věnována problematice rozvíjení interkulturní komunikační kompetence (IKK) a její integraci s rozvíjením řečových dovedností ve výuce anglického jazyka (AJ) na 2. stupni ZŠ. V rámci hledání odpovědi na otázku, jakým způsobem a za jakých podmínek rozvíjení IKK ve výuce AJ probíhá, je cílem této studie nahlédnout do toho, v integraci s jakými řečovými dovednostmi je IKK rozvíjena a jaké je jejich zastoupení. Po úvodní části a vymezení teoretických východisek následuje část metodologická (kapitola 3) představující zkoumaný soubor (79 vyučovacích hodin AJ v 7. a 8. ročnících na

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Park, Min-Young, Ji-hyun Moon, Ki-Sung Lee та ін. "FAF1 Suppresses IκB Kinase (IKK) Activation by Disrupting the IKK Complex Assembly". Journal of Biological Chemistry 282, № 38 (2007): 27572–77. http://dx.doi.org/10.1074/jbc.c700106200.

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This study presents a molecular inhibitory mechanism by Fas-associated factor 1 (FAF1) on IκB kinase (IKK) activation, where divergent NF-κB-activating stimuli converge. FAF1 interacts with IKKβ in response to proinflammatory stimuli (such as tumor necrosis factor-α, interleukin-1β, and lipopolysaccharide) and suppresses IKK activation. Interaction of the leucine-zipper domain of IKKβ with FAF1 affected the IKK heterocomplex (IKKα/β) and homocomplex (IKKα/α, IKKβ/β) formations and attenuated IKKγ recruitment to IKKβ. Overexpression of FAF1 reduced the level of IKKβ activity, whereas FAF1 deple

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Muhammad Amar. "EFEKTIVITAS PELAYANAN TERHADAP PELANGGAN AIR BERSIH PDAM SPAM IKK KELURAHAN PASIR PUTIH KECAMATAN SINJAI BORONG." Jurnal Ilmu Administrasi Negara 19, no. 1 (2022): 165–76. http://dx.doi.org/10.59050/jian.v19i1.213.

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Penelitian ini bertujuan untuk untuk mengetahui bagaimana Pelayanan Terhadap Pelanggan Air Bersih Perusahaan Daerah Air Minum SPAM IKK Kelurahan Pasir Putih Kecamatan Sinjai Borong Kabupaten Sinjai ,untuk mengetahui prosedur pelayanan pelamggan air bersih, untuk mengetahui waktu penyelesaian pelayanan pelanggan air bersih mengetahui bagaimana Pelayanan Terhadap Pelanggan Air Bersih Perusahaan Daerah Air Minum SPAM IKK Kelurahan Pasir Putih Kecamatan Sinjai Borong Kabupaten Sinjai. Penelitian ini menggunakan deskriptif kualitatif, teknik pengumpulan data yaitu observasi, wawancara dan dokuemnta

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Mercurio, Frank, Brion W. Murray, Andrej Shevchenko та ін. "IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex". Molecular and Cellular Biology 19, № 2 (1999): 1526–38. http://dx.doi.org/10.1128/mcb.19.2.1526.

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ABSTRACT Activation of the transcription factor NF-κB is controlled by the sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit, IκB. We recently purified a large multiprotein complex, the IκB kinase (IKK) signalsome, which contains two regulated IκB kinases, IKK1 and IKK2, that can each phosphorylate IκBα and IκBβ. The IKK signalsome contains several additional proteins presumably required for the regulation of the NFκB signal transduction cascade in vivo. In this report, we demonstrate reconstitution of IκB kinase activity in vitro by using purified recombina

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Rajamani, Sridharan, Corey L. Anderson, Carmen R. Valdivia, et al. "Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and IKr." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 3 (2006): H1278—H1288. http://dx.doi.org/10.1152/ajpheart.00777.2005.

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KCNH2 ( hERG1) encodes the α-subunit proteins for the rapidly activating delayed rectifier K+ current ( IKr), a major K+ current for cardiac myocyte repolarization. In isolated myocytes IKr frequently is small in amplitude or absent, yet KCNH2 channels and IKr are targets for drug block or mutations to cause long QT syndrome. We hypothesized that KCNH2 channels and IKr are uniquely sensitive to enzymatic damage. To test this hypothesis, we studied heterologously expressed K+, Na+, and L-type Ca2+ channels, and in ventricular myoctyes IKr, slowly activating delayed rectifier K+ current ( IKs),

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Llona-Minguez, Sabin, Jessica Baiget та Simon P. Mackay. "Small-molecule inhibitors of IκB kinase (IKK) and IKK-related kinases". Pharmaceutical Patent Analyst 2, № 4 (2013): 481–98. http://dx.doi.org/10.4155/ppa.13.31.

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Lee, Dung-Fang, and Mien-Chie Hung. "Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy." Clinical Cancer Research 14, no. 18 (2008): 5656–62. http://dx.doi.org/10.1158/1078-0432.ccr-08-0123.

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Indra Digdoyono Notohamijoyo, MT, Setiadi. "INDEKS KUALITAS KEBIJAKAN SEBAGAI INSTRUMEN PENJAMIN MUTU KEBIJAKAN KETAHANAN DAGING SAPI DAN BERAS NASIONAL BERBASIS BUKTI." Jurnal Analis Kebijakan 4, no. 1 (2020): 41–56. http://dx.doi.org/10.37145/jak.v4i1.426.

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Mengacu kepada kebijakan publik berbasis bukti, Lembaga Administrasi Negara pada tahun2016 telah menerbitkan Indeks Kualitas Kebijakan (IKK). IKK adalah suatu instrumen penilaikualitas kebijakan publik sesuai harapan masyarakat. Harapan publik untuk ketahanan dagingsapi dan beras adalah mewujudkan Nawa Cita jilid II dalam penyediaan beras dan daging sapisecara mandiri guna memaksimalkan kesejahteraan petani.Tulisan ini akan menggunakan IKK dalam menilai dan merumuskan rekomendasiimplementasi kebijakan ketahanan beras dan daging sapi nasional sesuai harapan publik. Penilaian IKK difokuskan pada

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